Reaxys
PubChem
eMolecules
Reactions (21)
Yield
Substances (4)
Conditions
Citations (3)
References
1
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Rx-ID: 31058497 Find similar reactions
in ethanol; water
0.166667 h; Reflux;
2
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Smith, Graham; Cotton, Marcus S.; Wermuth, Urs D.; Boyd, Sue E.
Acta Crystallographica Section C: Crystal Structure Communications, 2010 , vol. 66, # 5 p. o252-o255 Title/Abstract Full Text View citing articles Show Details
Synthesize Find similar With sodium hydroxide in methanol
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Rx-ID: 8847905 Find similar reactions
Chambers; Kurrasch-Orbaugh; Parker; Nichols
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 1003 - 1010 Title/Abstract Full Text View citing articles Show Details
3
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Rx-ID: 8847906 Find similar reactions
Chambers; Kurrasch-Orbaugh; Parker; Nichols
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 1003 - 1010 Title/Abstract Full Text View citing articles Show Details
4
Synthesize Find similar Multi-step reaction with 7 steps 1: 91 percent / Br2; ZnCl2 / acetic acid 2: 79 percent / Mg; EtMgBr / tetrahydrofuran / 3 h / Heating 3: AlCl3 / CH2Cl2 / 16 h 4: 94 percent / TFA; Et3SiH / 6 h / Heating 5: 82 percent / Br2 / acetic acid / 4.5 h / 20 °C 6: 64 percent / DDQ / dioxane / 24 h / Heating 7: aq. 5 N NaOH / methanol View Scheme
5
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Rx-ID: 15299180 Find similar reactions
Chambers; Kurrasch-Orbaugh; Parker; Nichols
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 1003 - 1010 Title/Abstract Full Text View citing articles Show Details
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6
Multi-step reaction with 7 steps 1: 91 percent / Br2; ZnCl2 / acetic acid 2: 79 percent / Mg; EtMgBr / tetrahydrofuran / 3 h / Heating 3: AlCl3 / CH2Cl2 / 16 h 4: 92 percent / TFA; Et3SiH / 6 h / Heating 5: 79 percent / Br2 / acetic acid / 4.5 h / 20 °C 6: 68 percent / DDQ / dioxane / 24 h / Heating 7: aq. 5 N NaOH / methanol View Scheme
Multi-step reaction with 8 steps 1: 88 percent / SOCl2; pyridine / 20 °C 2: 91 percent / Br2; ZnCl2 / acetic acid 3: 79 percent / Mg; EtMgBr / tetrahydrofuran / 3 h / Heating 4: AlCl3 / CH2Cl2 / 16 h 5: 94 percent / TFA; Et3SiH / 6 h / Heating 6: 82 percent / Br2 / acetic acid / 4.5 h / 20 °C 7: 64 percent / DDQ / dioxane / 24 h / Heating 8: aq. 5 N NaOH / methanol View Scheme
Chambers; Kurrasch-Orbaugh; Parker; Nichols
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 1003 - 1010 Title/Abstract Full Text View citing articles Show Details
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Rx-ID: 15306639 Find similar reactions
Chambers; Kurrasch-Orbaugh; Parker; Nichols
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 1003 - 1010 Title/Abstract Full Text View citing articles Show Details
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Rx-ID: 15299181 Find similar reactions
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7
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Multi-step reaction with 8 steps 1: 88 percent / SOCl2; pyridine / 20 °C 2: 91 percent / Br2; ZnCl2 / acetic acid 3: 79 percent / Mg; EtMgBr / tetrahydrofuran / 3 h / Heating 4: AlCl3 / CH2Cl2 / 16 h 5: 92 percent / TFA; Et3SiH / 6 h / Heating 6: 79 percent / Br2 / acetic acid / 4.5 h / 20 °C 7: 68 percent / DDQ / dioxane / 24 h / Heating 8: aq. 5 N NaOH / methanol
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Rx-ID: 15306640 Find similar reactions
Chambers; Kurrasch-Orbaugh; Parker; Nichols
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 1003 - 1010 Title/Abstract Full Text View citing articles Show Details
View Scheme
8
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9
Multi-step reaction with 5 steps 1: AlCl3 / CH2Cl2 / 16 h 2: 94 percent / TFA; Et3SiH / 6 h / Heating 3: 82 percent / Br2 / acetic acid / 4.5 h / 20 °C 4: 64 percent / DDQ / dioxane / 24 h / Heating 5: aq. 5 N NaOH / methanol View Scheme
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Rx-ID: 15307123 Find similar reactions
Chambers; Kurrasch-Orbaugh; Parker; Nichols
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 1003 - 1010 Title/Abstract Full Text View citing articles Show Details
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Multi-step reaction with 5 steps 1: AlCl3 / CH2Cl2 / 16 h 2: 92 percent / TFA; Et3SiH / 6 h / Heating 3: 79 percent / Br2 / acetic acid / 4.5 h / 20 °C 4: 68 percent / DDQ / dioxane / 24 h / Heating 5: aq. 5 N NaOH / methanol View Scheme
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Rx-ID: 15307124 Find similar reactions
Chambers; Kurrasch-Orbaugh; Parker; Nichols
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 1003 - 1010 Title/Abstract Full Text View citing articles Show Details
10
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Rx-ID: 15310221 Find similar reactions
Multi-step reaction with 6 steps 1: 79 percent / Mg; EtMgBr / tetrahydrofuran / 3 h / Heating 2: AlCl3 / CH2Cl2 / 16 h 3: 94 percent / TFA; Et3SiH / 6 h / Heating 4: 82 percent / Br2 / acetic acid / 4.5 h / 20 °C 5: 64 percent / DDQ / dioxane / 24 h / Heating 6: aq. 5 N NaOH / methanol View Scheme
Chambers; Kurrasch-Orbaugh; Parker; Nichols
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 1003 - 1010 Title/Abstract Full Text View citing articles Show Details
11
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Multi-step reaction with 6 steps 1: 79 percent / Mg; EtMgBr / tetrahydrofuran / 3 h / Heating 2: AlCl3 / CH2Cl2 / 16 h 3: 92 percent / TFA; Et3SiH / 6 h / Heating 4: 79 percent / Br2 / acetic acid / 4.5 h / 20 °C 5: 68 percent / DDQ / dioxane / 24 h / Heating 6: aq. 5 N NaOH / methanol View Scheme
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Rx-ID: 15310222 Find similar reactions
Chambers; Kurrasch-Orbaugh; Parker; Nichols
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 1003 - 1010 Title/Abstract Full Text View citing articles Show Details
12
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13
Multi-step reaction with 3 steps 1: 82 percent / Br2 / acetic acid / 4.5 h / 20 °C 2: 64 percent / DDQ / dioxane / 24 h / Heating 3: aq. 5 N NaOH / methanol View Scheme
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Rx-ID: 15325685 Find similar reactions
Chambers; Kurrasch-Orbaugh; Parker; Nichols
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 1003 - 1010 Title/Abstract Full Text View citing articles Show Details
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Multi-step reaction with 3 steps 1: 79 percent / Br2 / acetic acid / 4.5 h / 20 °C 2: 68 percent / DDQ / dioxane / 24 h / Heating 3: aq. 5 N NaOH / methanol View Scheme
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Rx-ID: 15325693 Find similar reactions
Chambers; Kurrasch-Orbaugh; Parker; Nichols
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 1003 - 1010 Title/Abstract Full Text View citing articles Show Details
14
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Multi-step reaction with 4 steps 1: 94 percent / TFA; Et3SiH / 6 h / Heating 2: 82 percent / Br2 / acetic acid / 4.5 h / 20 °C 3: 64 percent / DDQ / dioxane / 24 h / Heating 4: aq. 5 N NaOH / methanol View Scheme
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Rx-ID: 15326442 Find similar reactions
Chambers; Kurrasch-Orbaugh; Parker; Nichols
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 1003 - 1010 Title/Abstract Full Text View citing articles Show Details
15
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Multi-step reaction with 4 steps 1: 92 percent / TFA; Et3SiH / 6 h / Heating 2: 79 percent / Br2 / acetic acid / 4.5 h / 20 °C 3: 68 percent / DDQ / dioxane / 24 h / Heating 4: aq. 5 N NaOH / methanol View Scheme
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Rx-ID: 15326453 Find similar reactions
Chambers; Kurrasch-Orbaugh; Parker; Nichols
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 1003 - 1010 Title/Abstract Full Text View citing articles Show Details
16
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Multi-step reaction with 2 steps 1: 64 percent / DDQ / dioxane / 24 h / Heating 2: aq. 5 N NaOH / methanol View Scheme
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Rx-ID: 15327442 Find similar reactions
Chambers; Kurrasch-Orbaugh; Parker; Nichols
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 1003 - 1010 Title/Abstract Full Text View citing articles Show Details
17
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Multi-step reaction with 2 steps 1: 68 percent / DDQ / dioxane / 24 h / Heating 2: aq. 5 N NaOH / methanol View Scheme
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Rx-ID: 15327446 Find similar reactions
Chambers; Kurrasch-Orbaugh; Parker; Nichols
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 1003 - 1010 Title/Abstract Full Text View citing articles Show Details
18
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With sodium hydroxide in methanol
12 h; Ambient temperature;
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Rx-ID: 5121917 Find similar reactions
Parker, Matthew A.; Marona-Lewicka, Danuta; Lucaites, Virginia L.; Nelson, David L.; Nichols, David E.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 26 p. 5148 - 5149 Title/Abstract Full Text View citing articles Show Details
19
Synthesize Find similar Multi-step reaction with 4 steps 1: 87 percent / Et3N / CH2Cl2 / 2 h / 0 - 20 °C 2: 71 percent / Br2, AcOH / 5 h / 15 - 20 °C 3: 89 percent / DDQ / toluene / 10.5 h / Heating 4: aq. NaOH / methanol / 12 h / Ambient temperature View Scheme
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Rx-ID: 16445360 Find similar reactions
Parker, Matthew A.; Marona-Lewicka, Danuta; Lucaites, Virginia L.; Nelson, David L.; Nichols, David E.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 26 p. 5148 - 5149 Title/Abstract Full Text View citing articles Show Details
20
Synthesize Find similar Multi-step reaction with 3 steps 1: 71 percent / Br2, AcOH / 5 h / 15 - 20 °C 2: 89 percent / DDQ / toluene / 10.5 h / Heating 3: aq. NaOH / methanol / 12 h / Ambient temperature View Scheme
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Rx-ID: 16455630 Find similar reactions
Parker, Matthew A.; Marona-Lewicka, Danuta; Lucaites, Virginia L.; Nelson, David L.; Nichols, David E.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 26 p. 5148 - 5149 Title/Abstract Full Text View citing articles Show Details
21
Synthesize Find similar Multi-step reaction with 2 steps 1: 89 percent / DDQ / toluene / 10.5 h / Heating 2: aq. NaOH / methanol / 12 h / Ambient temperature View Scheme
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Rx-ID: 16457110 Find similar reactions
Parker, Matthew A.; Marona-Lewicka, Danuta; Lucaites, Virginia L.; Nelson, David L.; Nichols, David E.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 26 p. 5148 - 5149 Title/Abstract Full Text View citing articles Show Details