Reaxys
PubChem
eMolecules
Reactions (12)
Yield
Substances (3)
Citations (6)
Conditions
References
1
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With lithium aluminium tetrahydride in tetrahydrofuran
2
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Rx-ID: 8029149
Rx-ID: 4410156 Find similar reactions
Kotera,K. et al.
Tetrahedron, 1968 , vol. 24, p. 3681 - 3696 Full Text View citing articles Show Details
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Vargha; Gyoerffy
Magyar chem.FolyoiratChem.Abstr., 1944 , vol. 50, p. 6,11 Magyar chem.FolyoiratChem.Abstr., 1948 , p. 1219 Full Text Show Details
3
Synthesize Find similar 67%
With lithium aluminium tetrahydride in dichloromethane
T=80°C; 48 h;
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Rx-ID: 10039492 Find similar reactions
Rothman, Richard B.; Blough, Bruce E.; Woolverton, William L.; Anderson, Karen G.; Negus, S. Stevens; Mello, Nancy K.; Roth, Bryan L.; Baumann, Michael H.
Journal of Pharmacology and Experimental Therapeutics, 2005 , vol. 313, # 3 p. 1361 - 1369 Title/Abstract Full Text View citing articles Show Details
4
Synthesize Find similar Multi-step reaction with 2 steps 1: ammonium acetate / Heating 2: 67 percent / lithium aluminum hydride / CH2Cl2 / 48 h / 80 °C View Scheme
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Rx-ID: 12877110 Find similar reactions
Rothman, Richard B.; Blough, Bruce E.; Woolverton, William L.; Anderson, Karen G.; Negus, S. Stevens; Mello, Nancy K.; Roth, Bryan L.; Baumann, Michael H.
Journal of Pharmacology and Experimental Therapeutics, 2005 , vol. 313, # 3 p. 1361 - 1369 Title/Abstract Full Text View citing articles Show Details
5
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With lithium aluminium tetrahydride in tetrahydrofuran
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Rx-ID: 30558158 Find similar reactions
Rodriguez-Mata, Maria; Gotor-Fernandez, Vicente; Gonzalez-Sabin, Javier; Rebolledo, Francisca; Gotor, Vicente
12 h; Inert atmosphereReflux;
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 7 p. 2274 - 2278 Title/Abstract Full Text View citing articles Show Details
6
Synthesize Find similar Multi-step reaction with 2 steps 1: ammonium acetate / 6 h / Reflux 2: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / Inert atmosphere; Reflux View Scheme
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Rx-ID: 30558169 Find similar reactions
Rodriguez-Mata, Maria; Gotor-Fernandez, Vicente; Gonzalez-Sabin, Javier; Rebolledo, Francisca; Gotor, Vicente
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 7 p. 2274 - 2278 Title/Abstract Full Text View citing articles Show Details
7
Synthesize Find similar With hydrogenchloride; water
Hydrolysis; 1 h; Heating;
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Rx-ID: 5072785 Find similar reactions
Gajda, Tadeusz; Napieraj, Anna; Osowska-Pacewicka, Krystyna; Zawadzki, Stefan; Zwierzak, Andrzej
Tetrahedron, 1997 , vol. 53, # 13 p. 4935 - 4946 Title/Abstract Full Text View citing articles Show Details
8
Synthesize Find similar Multi-step reaction with 2 steps 1: CuI / tetrahydrofuran / -30 - 0 °C 2: HCl; H2O / 1 h / Heating View Scheme
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Rx-ID: 16563039 Find similar reactions
Gajda, Tadeusz; Napieraj, Anna; Osowska-Pacewicka, Krystyna; Zawadzki, Stefan; Zwierzak, Andrzej
Tetrahedron, 1997 , vol. 53, # 13 p. 4935 - 4946 Title/Abstract Full Text View citing articles Show Details
9
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40%
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Stage #1: With lithium aluminium tetrahydride in tetrahydrofuran
Rx-ID: 28611839 Find similar reactions
Vilches-Herrera, Marcelo; Miranda-Sepulveda, Juan; Rebolledo-Fuentes, Marco; Fierro, Angelica; Luehr, Susan; Iturriaga-Vasquez, Patricio; Cassels, Bruce K.; Reyes-Parada, Miguel
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 6 p. 2452 - 2460 Title/Abstract Full Text View citing articles Show Details
Reflux; Stage #2: With sodium hydroxide; water in tetrahydrofuran
T=20°C; Stage #3: With hydrogenchloride in water; isopropyl alcohol
A
B
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10
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Rx-ID: 30558154 Find similar reactions
A: 96% B: 99%
With lipase B from Candida antarctica in tetrahydrofuran
T=30°C; 5 h; Inert atmosphereEnzymatic reaction; optical yield given as percent ee;
Rodriguez-Mata, Maria; Gotor-Fernandez, Vicente; Gonzalez-Sabin, Javier; Rebolledo, Francisca; Gotor, Vicente
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 7 p. 2274 - 2278 Title/Abstract Full Text View citing articles Show Details
A
B
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11
Synthesize Find similar Rx-ID: 30558156 Find similar reactions
Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / Inert atmosphere; Reflux 2: lipase B from Candida antarctica / tetrahydrofuran / 5 h / 30 °C /
Rodriguez-Mata, Maria; Gotor-Fernandez, Vicente; Gonzalez-Sabin, Javier; Rebolledo, Francisca; Gotor, Vicente
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 7 p. 2274 - 2278 Title/Abstract Full Text View citing articles Show Details
Inert atmosphere; Enzymatic reaction View Scheme
A
B
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12
Synthesize Find similar Rx-ID: 30558167 Find similar reactions
Multi-step reaction with 3 steps 1: ammonium acetate / 6 h / Reflux 2: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / Inert atmosphere; Reflux 3: lipase B from Candida antarctica / tetrahydrofuran / 5 h / 30 °C / Inert atmosphere; Enzymatic reaction View Scheme
Rodriguez-Mata, Maria; Gotor-Fernandez, Vicente; Gonzalez-Sabin, Javier; Rebolledo, Francisca; Gotor, Vicente
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 7 p. 2274 - 2278 Title/Abstract Full Text View citing articles Show Details