Reaxys
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Substances (1)
Citations (1763)
Structure
Structure/Compound Data Chemical Name: 2-amino-1-phenylpropane Reaxys Registry Number: 507867
CAS Registry Number: 60-15-1, 156-34-3, 51-64-9, 300-62-9 Type of Substance: isocyclic Molecular Formula: C9H13N Linear Structure Formula: C6H5CH2CH(CH3)NH2
Molecular Weight: 135.209 InChI Key: KWTSXDURSIMDCE-UHFFFAOYSA-N
1
Synthesize | Hide Details Find similar Chemical Names and Synonyms 2-amino-1-phenylpropane, AMPHETAMINE Identification Substance Label (32) Label
Reference
c
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AMPH
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N° of preparations All Preps | All Reactions 84 prep out of 599 reactions.
Available Data
N° of ref.
Identification Physical Data (113) Spectra (81) Bioactivity (317) Other Data (299)
1763
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amph
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(±)-7b
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12a
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Amphetamine
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rac-9
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AM
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Amp
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tab. 1, entry 2, prod.
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Amph
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R-NH2, f
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11m
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AP
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Li, Yanjun; Izumi, Taeko
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(+/-)-1
Gonzalez-Sabin, Javier; Gotor, Vicente; Rebolledo, Francisca
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(+/-)-7
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4
Li, Yanjun; Izumi, Taeko
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AMPH; A
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f'
Bansal, Ekta; Srivastava; Kumar, Ashok
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8, T2, entry I
Subramanyam
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27
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Patent-Specific Data (3)
Prophetic Compound
Related Markush Structure (RN)
Reference
20353528
Johnson Matthey Public Limited Company
Patent: US2010/125146 A1, 2010 ; Title/Abstract Full Text Show Details
19815298
Yamakawa Chemical Industry Co., Ltd.
Patent: US6342636 B1, 2002 ; Title/Abstract Full Text Show Details
prophetic product
Sumitomo Chemical Company, Limited
Patent: US4698421 A1, 1987 ;
Title/Abstract Full Text Show Details
Related Structure (2) Related Structure
Reference
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Configuration.
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Helvetica Chimica Acta, 1951 , vol. 34, p. 2202,2208 Full Text Show Details
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Cervinka et al.
Zeitschrift fuer Chemie (Stuttgart, Germany), 1968 , vol. 8, p. 24 Full Text Show Details
Derivative (41) Derivative
Comment (Derivative)
Reference
amphetamine hydrochloride
Kabalka, George W.; Laila Guindi; Varma, Rajender S.
Tetrahedron, 1990 , vol. 46, # 21 p. 7443 - 7457 Title/Abstract Full Text View citing articles Show Details
amphetamine hydrochloride
Jilek, Jiri; Urban, Jiri; Taufmann, Petr; Holubek, Jiri; Dlabac, Antonin; et al.
Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 7 p. 1995 - 2008 Title/Abstract Full Text Show Details
(1-Methyl-2-phenylethyl)trimethylsilanylamine
Rucker; Neugebauer; Heiden
Arzneimittel-Forschung/Drug Research, 1988 , vol. 38, # 4 p. 497 - 501 Title/Abstract Full Text View citing articles Show Details
Sulfat (I): Spektrofluorometrische Bestimmung mit Fluorescamin; Luminescenzeigenschaften; Fluorescenzkurve (pH-Abhaengigkeit)
De Silva; Strojny
Analytical Chemistry, 1975 , vol. 47, p. 714,716, 718 Full Text View citing articles Show Details
Pikrolonat: F: 175-178grad
Kuhnert-Brandstaetter et al.
Pharmaceutica Acta Helvetiae, 1975 , vol. 50, p. 360,364 Full Text Show Details
Pikrolonat: F: 185-188grad
Kuhnert-Brandstaetter et al.
Pharmaceutica Acta Helvetiae, 1975 , vol. 50, p. 360,364 Full Text Show Details
Sulfat: F: 260-275grad; UV; λ(max); ε; Zers.: 300-320grad in Silicagel; eutektische Temperatur mit Saccharin: 180grad: eutektische Temperatur mit Phenolphthalein: 219grad
Kuhnert-Brandstaetter et al.
Pharmaceutica Acta Helvetiae, 1975 , vol. 50, p. 360,364 Full Text Show Details
Sulfat: F: 285-310grad; UV; λ(max); ε; eutektische Temperatur mit Phenolphthalein: 232grad: eutektische Temperatur mit 4-Sulfamoylbenzoesaeure: 233grad; eutektische Temperatur mit Dicyandiamid: 165grad
Kuhnert-Brandstaetter et al.
Pharmaceutica Acta Helvetiae, 1975 , vol. 50, p. 360,364 Full Text Show Details
Acetylderivat : F:90-92grad
Landor et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1974 , p. 1294,1299 Full Text Show Details
Komplex: Amphet(?)aminsulfat*FMN; Abs.-Sp., K
Sung; Parker
Zeitschrift fuer Naturforschung, C: Journal of Biosciences, 1974 , vol. 29, p. 122,124 Full Text Show Details
Hexafluoroacetonaddukt : 19F-NMR
Leader
Analytical Chemistry, 1973 , vol. 45, p. 1700,1706 Full Text Show Details
Bisulfat-Salz: λ(ex), λ(em) fuer Fluoreszenz und Phosphoreszenz, rel. Quantenwirksamkeit in 0,1 n wss. H2SO4 in Ggw. von Luft
Miles; Schenk
Analytical Chemistry, 1973 , vol. 45, p. 130,132 Full Text Show Details
Sulfat: IR
Blang; Huang
Journal of Pharmaceutical Sciences, 1973 , vol. 62, p. 652 Full Text View citing articles Show Details
Blang; Huang
Journal of Pharmaceutical Sciences, 1972 , vol. 61, p. 1770,1772, 1774 Full Text View citing articles Show Details
Hydrochlorid: aus der unmarkierten Verbindung mit tritiierter Phosphorsaeure*BF3 nach der Methode von Yavorsky, Gorin, J. Am. Chem. Soc. 84<1962>1071
Telc et al.
Journal of Labelled Compounds, 1972 , vol. 8, p. 13,14, 19 Full Text Show Details
als N,N-Bis-trifluoracetyl-Derivat
Ehrsson; Broetel
Acta Pharmaceutica Suecica, 1971 , vol. 8, p. 591,596 Full Text Show Details
als N,N-Bis-heptafluorbutyl-Derivat
Ehrsson; Broetel
Acta Pharmaceutica Suecica, 1971 , vol. 8, p. 591,596 Full Text Show Details
H2SO4-Salz: Kristallstruktur
Bergin; Carlstroem
Acta Crystallographica, Section B: Structural Crystallography and Crystal Chemistry, 1971 , vol. 27, p. 2146,2151 Full Text Show Details
*H2SO4: 1H-NMR; IR-Spektrum; UV; pK
Warren et al.
Journal - Association of Official Analytical Chemists, 1971 , vol. 54, p. 1179,1181,1186,1188 Full Text View citing articles Show Details
Hydrochlorid C9H14ClN: NMR-Daten (Tab.I); Rotameren-Verteilg. (Fig.2)
Neville et al.
Journal of Medicinal Chemistry, 1971 , vol. 14, p. 717,718 Full Text Show Details
Sulfat: Rk. mit 2,5-Dimethoxytetrahydrofuran, p-(Dimethylamino)-benzaldehyd (Photometr. Messung, Ext. Max.)
Fontani; Morandini
The Journal of pharmacy and pharmacology, 1970 , vol. 22, # 6 p. 411 - 413 Title/Abstract Full Text View citing articles Show Details
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Comment (Derivative)
Reference
Hydrochlorid, pK(a): 9.07
Garrett, Chembarkar
Journal of Pharmaceutical Sciences, 1968 , vol. 57, p. 1401,1402 Full Text Show Details
Hydrochlorid: B: aus 1-Chlor-1-phenyl-2-amino-propan-Hydrochlorid, H2 <Pd-C>
Kotera,K. et al.
Tetrahedron, 1968 , vol. 24, p. 5677 - 5690 Full Text View citing articles Show Details
Salz m. Na2SO3: B.; λ(max); ν(max)
Griffin; Banker
Journal of Pharmaceutical Sciences, 1967 , vol. 56, p. 1098,1099 Full Text Show Details
Salz m. Mannose-sulfonat: B.; λ(max); ν(max)
Griffin; Banker
Journal of Pharmaceutical Sciences, 1967 , vol. 56, p. 1098,1099 Full Text Show Details
Salz m. Glucose-sulfonat; B., P. (v. Mannose-Verb.)
Griffin; Banker
Journal of Pharmaceutical Sciences, 1967 , vol. 56, p. 1098,1099 Full Text Show Details
Hydrochlorid: Rkt. mit 1. Benzaldehyd od. Anisaldehyd; 2. KCN --> N-(β-Phenyl-isopropyl)-α-amino-phenylessigsaeurenitril bzw. N-(β-Phenyl-isopropyl)-α-amino-p-methoxy-phenylessigsaeurenitril-Hydrochlorid
Kholodov,L.E. et al.
Zhurnal Organicheskoi Khimii, 1967 , vol. 3, # 8 p. 1513 - 1518,1470 - 1474 Full Text View citing articles Show Details
Sulfat C9H13N*H2SO4. UV-max. < MeOH >.
Kracmar; Kracmarova
Cesko-Slovenska Farmacie, 1966 , vol. 15, p. 16,18 Full Text Show Details
H2SO4*: IR-Spectrum
Hayden et al.
Journal - Association of Official Analytical Chemists, 1966 , vol. 49, p. 1109,1119 Full Text Show Details
Sulfat: λ(max), Tab. II
Sinsheimer; Keuhnelian
Journal of pharmaceutical sciences, 1966 , vol. 55, # 11 p. 1240 - 1244 Title/Abstract Full Text View citing articles Show Details
Cyclohexylsulfamidsaeure-Salz. C9H13N*C6H13NO3S. B. aus DL-1-Phenyl-2-amino-propan u. Cyclohexylsulfamidsaeure in Acn. od.Me. F:130grad(aus A. + Ae.)
Sciortino
Bollettino Chimico Farmaceutico, 1966 , vol. 105, p. 223,224 Full Text Show Details
Sulfat: ν(max), Tab. I
Thompson,W.E. et al.
Journal of Pharmaceutical Sciences, 1965 , vol. 54, p. 1819 - 1821 Full Text View citing articles Show Details
Succinat. C9H13N*C4H6O4. Krist. aus Acetonitril. F:162-163grad(korr.).
ELSLAGER; WEINSTEIN; WORTH
Journal of medicinal chemistry, 1964 , vol. 7, p. 493 - 500 Title/Abstract Full Text View citing articles Show Details
Succinat. B. aus 1-<2-Diaethylamino-aethyl>-2-<1-phenyl-2-propyl>-hydrazin u. Bernsteinsaeure in Acn.
ELSLAGER; WEINSTEIN; WORTH
Journal of medicinal chemistry, 1964 , vol. 7, p. 493 - 500 Title/Abstract Full Text View citing articles Show Details
Hydrochlorid: IR-Spektrum
Brannon; Hayden
Journal of the Association of Official Agricultural Chemists, 1964 , vol. 47, p. 918,927 Full Text Show Details
Oxalat 2<C9H13N>*C2H2O4. mp: 237-238grad < nach Hershberg; korr.; EtOH >; IR-Bande < Nujol >: 6.28-6.67μ
Nace; King
Journal of Medicinal and Pharmaceutical Chemistry, 1962 , vol. 5, p. 1316,1321 Full Text Show Details
Benzoyl-Derivat. mp: 132-133grad.
Bose; Raychaudhuri
Journal of the Indian Chemical Society, 1961 , vol. 38, p. 217,219 Full Text Show Details
Sulfat: F:260-275grad, eutekt.Temp.
Brandstaetter-Kuhnert et al.
Scientia Pharmaceutica, 1960 , vol. 28, # 1 p. 7,8-15 Chem.Abstr., 1960 , # 17802 Full Text Show Details
Reineckat; Zers.: 132grad; Loeslichk.; ε
Kum-Tatt
Journal of Pharmacy and Pharmacology, 1960 , vol. 12, p. 666 Full Text Show Details
Addukt m.N-Acetylmethionin, aus den Komponenten, F:148grad
Soc. Chim. Org. Biol.
Patent: FRM79 , 1960 ; Chem.Abstr., 1963 , vol. 58, # 10302g Full Text Show Details
Reineckat. mp:132grad < Zers.>; Loeslichkeit in H2O bei 5grad u. 27grad( Tab. I )
Kum-Tatt
Journal of Pharmacy and Pharmacology, 1960 , vol. 12, p. 666 Full Text Show Details
Sulfat. F:260-275grad. Schmelz-Verh. Eutekt. Temp. mit Salophen;190grad, mit Dicyandiamid: 163grad(156grad inst.)
Brandstaetter-Kuhnert et al.
Scientia Pharmaceutica, 1960 , vol. 28, # 1 p. 7,8-15 Chem.Abstr., 1960 , # 17802 Full Text Show Details
Physical Data Melting Point (1) Reference
Gal et al.
Acta Pharmaceutica Suecica, 1977 , vol. 14, p. 335,340 Full Text Show Details
Boiling Point (18) Boiling Point
Pressure (Boiling Point)
Reference
45 °C
0.5 Torr
Gonzalez-Sabin, Javier; Gotor, Vicente; Rebolledo, Francisca
Tetrahedron Asymmetry, 2002 , vol. 13, # 12 p. 1315 - 1320 Title/Abstract Full Text View citing articles Show Details
102 °C
16 Torr
Li, Yanjun; Izumi, Taeko
Journal of the Chinese Chemical Society (Taipei, Taiwan), 2002 , vol. 49, # 4 p. 505 - 508 Title/Abstract Full Text View citing articles Show Details
81 - 86 °C
10 - 12 Torr
Smith, Roger A.; White, Robert L.; Krantz, Allen
Journal of Medicinal Chemistry, 1988 , vol. 31, # 8 p. 1558 - 1566 Title/Abstract Full Text View citing articles Show Details
102 - 104 °C
22 Torr
Woodruff; Conger
Journal of the American Chemical Society, 1938 , vol. 60, p. 465 Full Text View citing articles Show Details
Abignente; Biniecka Picazio
Acta Poloniae Pharmaceutica - Drug Research, 1977 , vol. 34, # 3 p. 241 - 244 Title/Abstract Full Text View citing articles Show Details
44 °C
0.3 Torr
Neville et al.
Journal of Medicinal Chemistry, 1971 , vol. 14, p. 717,718 Full Text Show Details
120 - 130 °C
20 Torr
Kotera,K. et al.
Tetrahedron, 1968 , vol. 24, p. 5677 - 5690 Full Text View citing articles Show Details
83 °C
10 Torr
Cervinka,O. et al.
Collection of Czechoslovak Chemical Communications, 1968 , vol. 33, p. 3551 - 3557 Full Text View citing articles Show Details
77 - 78 °C
9 Torr
Kindler,K.; Luehrs,K.
Justus Liebigs Annalen der Chemie, 1967 , vol. 707, p. 26 - 34 Full Text View citing articles Show Details
91 - 93 °C
17 Torr
Prajsnar
Zeszyty Naukowe Politechniki Slaskiej, Chemia, 1963 , vol. 20, p. 1,72 Full Text Show Details
99 °C
20 Torr
Christol et al.
Bulletin de la Societe Chimique de France, 1961 , p. 2317 Full Text Show Details
74 °C
8 Torr
Biel et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 2805,2810, 2813 Full Text View citing articles Show Details
197 - 198 °C
750 Torr
Kornblum; Iffland
Journal of the American Chemical Society, 1949 , vol. 71, p. 2137,2138,2140 Full Text View citing articles Show Details
91 °C
15 Torr
Kornblum; Iffland
Journal of the American Chemical Society, 1949 , vol. 71, p. 2137,2138,2140 Full Text View citing articles Show Details
80 °C
10 Torr
Haskelberg
Journal of the American Chemical Society, 1948 , vol. 70, p. 2811 Full Text View citing articles Show Details
205 °C
Hey
Journal of the Chemical Society, 1930 , p. 18,20 Full Text Show Details
Jaeger; van Dijk
Proceedings of the Koninklijke Nederlandse Akademie van Wetenschappen, Series B: Physical Sciences, 1941 , vol. 44, p. 26,36,37 Full Text Show Details
63 - 64 °C
7 Torr
Jaeger; van Dijk
Proceedings of the Koninklijke Nederlandse Akademie van Wetenschappen, Series B: Physical Sciences, 1941 , vol. 71, p. 26,27
Full Text Show Details
90 °C
20 Torr
Couturier
Annales de Chimie (Cachan, France), 1938 , vol. <11> 10, p. 559,597 Full Text Show Details
203 °C
Edeleanu
Chemische Berichte, 1887 , vol. 20, p. 618 Full Text Show Details
Refractive Index (3) Refractive Index
Wavelength (Refractive Index)
Temperature (Refractive Index)
Reference
1.5175
589 nm
20 °C
Hoek et al.
Recueil des Travaux Chimiques des Pays-Bas, 1966 , vol. 85, p. 1039,1043 Full Text Show Details
1.5179
589 nm
20 °C
Biel et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 2805,2810, 2813 Full Text View citing articles Show Details
1.5185
589 nm
20 °C
Kornblum; Iffland
Journal of the American Chemical Society, 1949 , vol. 71, p. 2137,2138,2140 Full Text View citing articles Show Details
Density (1) Density
Measurement Temperature
Reference
0.937 g·cm-3
18 °C
Jaeger; van Dijk
Proceedings of the Koninklijke Nederlandse Akademie van Wetenschappen, Series B: Physical Sciences, 1941 , vol. 71, p. 26,27 Full Text Show Details
Adsorption (MCS) (1) Description (Adsorption (MCS))
Reference
Adsorption
Zapior; Czapkiewicz
Roczniki Chemii, 1962 , vol. 36, p. 1863,1866,1867 Chem.Abstr., vol. 58, # 11986 Full Text Show Details
Association (MCS) (10) Description (Association (MCS))
Partner (Association (MCS))
Solvent (Association (MCS))
Temperature (Association (MCS))
NMR spectrum of the complex
2A,2B,2C,2D,2E,2F,2G,3A,3B,3C,3D,3E,3F,3Gtetradeca-O-acetyl-β-cyclodextrin
D2O
26 °C
Thunhorst, Martin; Holzgrabe, Ulrike
Magnetic Resonance in Chemistry, 1998 , vol. 36, # 3 p. 211 216 Title/Abstract Full Text View citing articles Show Details
NMR spectrum of the complex
t-butylphenylphosphinothioic acid
CDCl3
Omelanczuk, Jan; Mikolajczyk, Marian
Tetrahedron Asymmetry, 1996 , vol. 7, # 9 p. 2687 - 2694 Title/Abstract Full Text View citing articles Show Details
Stability constant of the complex with ...
melanin
dimethylsulfoxide aq. phosphate buffer
36 °C
Nakahara; Takahashi; Kikura
Biological and Pharmaceutical Bulletin, 1995 , vol. 18, # 9 p. 1223 - 1227 Title/Abstract Full Text View citing articles Show Details
Stability constant of the complex with ...
H2O
dibutyl ether
21 °C
Tsai, Ruey-Shiuan; Fan, Weizheng; El Tayar, Nabil; Carrupt, Pierre-Alain; Testa, Bernard; Kier, Lemont B.
Journal of the American Chemical Society, 1993 , vol. 115, # 21 p. 9632 - 9639 Title/Abstract Full Text View citing articles Show Details
NMR spectrum of the complex
ethenetetracarbonitrile
Meincke; Kottke; Beyrich
Pharmazie, 1992 , vol. 47, # 9 p. 697 - 699 Title/Abstract Full Text View citing articles Show Details
Association with
iodine
CHCl3
Meincke; Kottke; Beyrich
Reference
compound
Pharmazie, 1992 , vol. 47, # 10 p. 780 - 783 Title/Abstract Full Text View citing articles Show Details
Association with compound
iodine
CCl4
Meincke; Kottke; Beyrich
Pharmazie, 1992 , vol. 47, # 10 p. 780 - 783 Title/Abstract Full Text View citing articles Show Details
Association with compound
iodine
octane
Meincke; Kottke; Beyrich
Pharmazie, 1992 , vol. 47, # 10 p. 780 - 783 Title/Abstract Full Text View citing articles Show Details
NMR spectrum of the complex
(S,S)(-)-1,6-bis-(o-chlorophenyl)-1,6diphenylhexa-2,4-diyne-1,6-diol
Toda, Fumio; Mori, Koji; Okada, Jyoji; Node, Manabu; Itoh, Akichika; et al.
Chemistry Letters, 1988 , p. 131 - 134 Title/Abstract Full Text Show Details
NMR spectrum of the complex
(S)-1,1'-bi-2-naphthol
Toda, Fumio; Mori, Koji; Okada, Jyoji; Node, Manabu; Itoh, Akichika; et al.
Chemistry Letters, 1988 , p. 131 - 134 Title/Abstract Full Text Show Details
Boundary Surface Phenomena (MCS) (1) Description (Boundary Surface Phenomena (MCS))
Reference
Surface tension
Zapior; Czapkiewicz
Roczniki Chemii, 1962 , vol. 36, p. 1863,1866,1867 Chem.Abstr., vol. 58, # 11986 Full Text Show Details
Chromatographic Data (5) Chromatographic data
Location
Reference
GC (Gas chromatography)
Malekzadeh, Hanieh; Fatemi, Mohammad H.
Bulletin of the Chemical Society of Japan, 2015 , vol. 88, # 5 p. 706 - 712 Title/Abstract Full Text View citing articles Show Details
Robayo, Diego A. Sánchez; Mendez, William F. Garzón; Ocampo, Gonzalo Taborda; Moreano, Milton Rosero
Journal of the Brazilian Chemical Society, 2016 , vol. 27, # 6 p. 992 - 997 Title/Abstract Full Text View citing articles Show Details
Ademiluyi, Adedayo O.; Ogunsuyi, Opeyemi B.; Oboh, Ganiyu
NeuroToxicology, 2016 , vol. 56, p. 107 - 117 Title/Abstract Full Text View citing articles Show Details
TLC (Thin layer chromatography)
Noreen; Farman
Asian Journal of Chemistry, 2016 , vol. 28, # 5 p. 1007 - 1010 Title/Abstract Full Text View citing articles Show Details
LC (Liquid chromatography)
Fedorova, Ganna; Randak, Tomas; Lindberg, Richard H.; Grabic, Roman
Rapid Communications in Mass Spectrometry, 2013 , vol. 27, # 15 p. 1751 - 1762 Title/Abstract Full Text View citing articles Show Details
Spinner; Klima; Kempf; Huppertz; Auwärter; Altenburger; Neukamm
Journal of Mass Spectrometry, 2014 , vol. 49, # 12 p. 1306 - 1313 Title/Abstract Full Text View citing articles Show Details
Jeong, Eun Sook; Kim, So-Hee; Cha, Eun-Ju; Lee, Kang Mi; Kim, Ho Jun; Lee, Sang-Won; Kwon, OhSeung; Lee, Jaeick
Rapid Communications in Mass Spectrometry, 2015 , vol. 29, # 4 p. 367 - 384 Title/Abstract Full Text View citing articles Show Details
Jeong, Eun Sook; Kim, So-Hee; Cha, Eun-Ju; Lee, Kang Mi; Kim, Ho Jun; Lee, Sang-Won; Kwon, OhSeung; Lee, Jaeick
Rapid Communications in Mass Spectrometry, 2015 , vol. 29, # 4 p. 367 - 384 Title/Abstract Full Text Show Details
GC (Gas chromatography)
supporting information
Martínez-Montero, Lía; Díaz-Rodríguez, Alba; Gotor, Vicente; Gotor-Fernández, Vicente; Lavandera, Iván
Green Chemistry, 2015 , vol. 17, # 5 p. 2794 - 2798 Title/Abstract Full Text View citing articles Show Details
UPLC (Ultra performance liquid chromatography)
Lin, Huei-Ru; Liao, Chao-Chuan; Lin, Tzu-Chieh
Rapid Communications in Mass Spectrometry, 2014 , vol. 28, # 19 p. 2043 - 2053 Title/Abstract Full Text View citing articles Show Details
Circular Dichroism (1) Reference
Ruckpaul et al.
Croatica Chemica Acta, 1977 , vol. 49, p. 339,343 Full Text Show Details
Conformation (1) Object of Investigation
Reference
Conformation
Pullman et al.
Journal of Medicinal Chemistry, 1972 , vol. 15, p. 17,20 Full Text Show Details
Neville et al.
Journal of Medicinal Chemistry, 1971 , vol. 14, p. 717,718 Full Text Show Details
Kumbar
Journal of Medicinal Chemistry, 1976 , vol. 19, p. 1232,1234 Full Text Show Details
El-Torki, Farid M.; Jacobus John
Journal of Organic Chemistry, 1985 , vol. 50, # 8 p. 1314 - 1316 Title/Abstract Full Text View citing articles Show Details
Crystal Property Description (6) Colour & Other Properties
Location
Reference
colourless
supporting information
Hong, Kai; Liu, Xun; Morken, James P.
Journal of the American Chemical Society, 2014 , vol. 136, # 30 p. 10581 - 10584 Title/Abstract Full Text View citing articles Show Details
Martínez-Montero, Lía; Díaz-Rodríguez, Alba; Gotor, Vicente; Gotor-Fernández, Vicente; Lavandera, Iván
Green Chemistry, 2015 , vol. 17, # 5 p. 2794 - 2798 Title/Abstract Full Text View citing articles Show Details
colourless
Schulze, Matthias
Synthetic Communications, 2010 , vol. 40, # 10 p. 1461 - 1476 Title/Abstract Full Text View citing articles Show Details
white
Collins, Michael; Salouros, Helen; Cawley, Adam T.; Robertson, James; Heagney, Aaron C.; Arenas-Queralt, Andrea
Rapid Communications in Mass Spectrometry, 2010 , vol. 24, # 11 p. 1653 - 1658 Title/Abstract Full Text View citing articles Show Details
orange
Vahermo, Mikko; Suominen, Tina; Leinonen, Antti; Yli-Kauhaluoma, Jari
Archiv der Pharmazie, 2009 , vol. 342, # 4 p. 201 - 209 Title/Abstract Full Text View citing articles Show Details
yellow
Guisado, Cristina; Waterhouse, Jodie E.; Price, Wayne S.; Jorgensen, Michael R.; Miller, Andrew D.
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 6 p. 1049 - 1057 Title/Abstract Full Text View citing articles Show Details
light-brown
Li, Yanjun; Izumi, Taeko
Journal of the Chinese Chemical Society (Taipei, Taiwan), 2002 , vol. 49, # 4 p. 505 - 508 Title/Abstract Full Text View citing articles Show Details
Dissociation Exponent (10) Dissociation Exponent (pK)
Dissociation Group
Temperature (Dissociation Exponent)
Solvent (Dissociation Exponent)
Method (Dissociation Exponent)
Type (Dissociation Exponent)
Comment (Dissociation Exponent)
10.1
a1/apparent
Huerta-Fontela, Maria; Galceran, Maria Teresa; Ventura, Francesc
Environmental Science and Technology, 2008 , vol. 42, # 18 p. 6809 - 6816 Title/Abstract Full Text View citing articles Show Details
-0.99
NH3(1+)
25 °C
H2O various solvent(s)
potentiometric
a1/thermodynamic
Athanasiou-Malaki; Koupparis; Hadjiioannou
(pk')pK(a)c: 9.90+-0.01 (H2O)
Reference
Analytical Chemistry, 1989 , vol. 61, # 13 p. 1358 - 1363 Title/Abstract Full Text View citing articles Show Details
Tencheva et al.
Arzneimittel Forschung, 1979 , vol. 29, p. 1331,1333
Full Text Show Details
(pk')logK(B)
Doyle; Proctor
Journal - Association of Official Analytical Chemists, 1972 , vol. 55, p. 328,329 Full Text Show Details
(pk')pK'(HA)
Modin; Johansson
Acta Pharmaceutica Suecica, 1971 , vol. 8, p. 561,565 Full Text Show Details
(k')
Chatten; Harris
Analytical Chemistry, 1962 , vol. 34, p. 1495,1499 Full Text Show Details
(pk')pK(b): 4.25
Zapior; Czapkiewicz
Roczniki Chemii, 1962 , vol. 36, p. 1863,1866,1867 Chem.Abstr., vol. 58, # 11986 Full Text Show Details
9.93
20 °C
H2O
potentiometric
a/apparent
Lewis
British Journal of Pharmacology and Chemotherapy, 1954 , vol. 9, p. 488,490 Full Text Show Details
4.23
25 °C
H2O
potentiometric
b/apparent
Leffler et al.
Journal of the American Chemical Society, 1951 , vol. 73, p. 2611 Full Text View citing articles Show Details
10.02
20 °C
H2O
potentiometric
a/apparent
Kieffer; Rumpf
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1950 , vol. 230, p. 2302 Full Text Show Details
Electrical Moment (1) Description (Electrical Moment)
Reference
Dipole moment
Kumbar
Journal of Medicinal Chemistry, 1976 , vol. 19, p. 1232,1234 Full Text Show Details
Electrochemical Behaviour (4) Description (Electrochemical Behaviour)
Reference
Basicity
Nagy, Peter I.; Alagona, Giuliano; Ghio, Caterina; Takacs-Novak, Krisztina
Journal of the American Chemical Society, 2003 , vol. 125, # 9 p. 2770 - 2785 Title/Abstract Full Text View citing articles Show Details
Protonation
Nagy, Peter I.; Alagona, Giuliano; Ghio, Caterina; Takacs-Novak, Krisztina
Journal of the American Chemical Society, 2003 , vol. 125, # 9 p. 2770 - 2785 Title/Abstract Full Text View citing articles Show Details
Electrochemical properties
Luca et al.
Revista de Chimie (Bucharest, Romania), 1979 , vol. 30, p. 72 Full Text Show Details
Chatten; Harris
Analytical Chemistry, 1962 , vol. 34, p. 1495,1499 Full Text Show Details
Stability constant
Lachman
Journal of Pharmaceutical Sciences, 1965 , vol. 54, p. 1519,1523 Full Text Show Details
Electrochemical Characteristics (2) Description (Electrochemical Characteristics)
Product XRN (Electrochemical Characteristics)
Product
Comment (Electrochemical Characteristics)
Reference
polarographic halfwave potential
polarographic halfwave potential
5744022
Type: Irreversible half-wave potential. Product: /BRN= 5744022/. Method: cyclovoltammetry. Description: Pt-electrode, CH3CN/NaClO4; CH2Cl2/C4H9/NClO4
Hess; Ziebig
Pharmazie, 1981 , vol. 36, # 4 p. 253 - 256 Title/Abstract Full Text View citing articles Show Details
Hess et al.
Pharmazie, 1976 , vol. 31, p. 452,453 Full Text Show Details
Formyl(Nmethoxymethyl-αmethyl)phenylethylamin
Further Information (36) Description (Further Information)
Reference
Further information
Coutts; Jones; Liu
Biomedical Mass Spectrometry, 1978 , vol. 5, # 6 p. 418 - 422 Title/Abstract Full Text View citing articles Show Details
Further information
Rein et al.
Croatica Chemica Acta, 1977 , vol. 49, p. 251,253, 254, 256, 257 Full Text Show Details
Further information
Predmore; Christian
Analytical chemistry, 1976 , vol. 48, # 2 p. 361 - 363 Title/Abstract Full Text View citing articles Show Details
Further information
Cartoni et al.
Bollettino Chimico Farmaceutico, 1976 , vol. 115, p. 347,350 Full Text Show Details
Further information
Hess et al.
Pharmazie, 1976 , vol. 31, p. 452,453 Full Text Show Details
Further information
Kuhnert-Brandstaetter et al.
Pharmaceutica Acta Helvetiae, 1975 , vol. 50, p. 360,364 Full Text Show Details
Further information
De Silva; Strojny
Analytical Chemistry, 1975 , vol. 47, p. 714,716, 718 Full Text View citing articles Show Details
Further information
Hunneman
Chemiker-Zeitung, 1974 , vol. 98, p. 28,32 Full Text Show Details
Further information
Sung; Parker
Zeitschrift fuer Naturforschung, C: Journal of Biosciences, 1974 , vol. 29, p. 122,124 Full Text Show Details
Further information
Miles; Schenk
Analytical Chemistry, 1973 , vol. 45, p. 130,132 Full Text Show Details
Further information
Blang; Huang
Journal of Pharmaceutical Sciences, 1973 , vol. 62, p. 652 Full Text View citing articles Show Details
Further information
Telc et al.
Journal of Labelled Compounds, 1972 , vol. 8, p. 13,14, 19 Full Text Show Details
Further information
Serck-Hanssen
Archives of Mass Spectral Data, 1971 , vol. 2, p. 760 Full Text Show Details
Further information
Bergin; Carlstroem
Acta Crystallographica, Section B: Structural Crystallography and Crystal Chemistry, 1971 , vol. 27, p. 2146,2151 Full Text Show Details
Further information
Warren et al.
Journal - Association of Official Analytical Chemists, 1971 , vol. 54, p. 1179,1181,1186,1188 Full Text View citing articles Show Details
Further information
Fontani; Morandini
The Journal of pharmacy and pharmacology, 1970 , vol. 22, # 6 p. 411 - 413
Title/Abstract Full Text View citing articles Show Details
Further information
Reisch; Alfes; Moellmann
Die Pharmazie, 1968 , vol. 23, # 5 p. 245 - 246 Title/Abstract Full Text View citing articles Show Details
Further information
Furman
Journal - Association of Official Analytical Chemists, 1968 , vol. 51, p. 1111,1115 Full Text Show Details
Further information
Garrett, Chembarkar
Journal of Pharmaceutical Sciences, 1968 , vol. 57, p. 1401,1402 Full Text Show Details
Further information
Cholodov et al.
Zhurnal Organicheskoi Khimii, 1967 , vol. 3, p. 1513,1470 Full Text Show Details
Hide facts Description (Further Information)
Reference
Further information
Griffin; Banker
Journal of Pharmaceutical Sciences, 1967 , vol. 56, p. 1098,1099 Full Text Show Details
Further information
Beckett et al.
Journal of Pharmacy and Pharmacology, 1967 , vol. 19, p. 273,291 Full Text Show Details
Further information
Kracmar; Kracmarova
Cesko-Slovenska Farmacie, 1966 , vol. 15, p. 16,18 Full Text Show Details
Further information
Hayden et al.
Journal - Association of Official Analytical Chemists, 1966 , vol. 49, p. 1109,1119 Full Text Show Details
Further information
Sciortino
Bollettino Chimico Farmaceutico, 1966 , vol. 105, p. 223,224 Full Text Show Details
Further information
Sinsheimer; Keuhnellan
Journal of Pharmaceutical Sciences, 1966 , vol. 55, p. 1240,1241 Full Text Show Details
Further information
Thompson,W.E. et al.
Journal of Pharmaceutical Sciences, 1965 , vol. 54, p. 1819 - 1821 Full Text View citing articles Show Details
Further information
Duvall; Koshy; Pyles
Journal of pharmaceutical sciences, 1965 , vol. 54, # 4 p. 607 - 611 Title/Abstract Full Text View citing articles Show Details
Further information
Brannon; Hayden
Journal of the Association of Official Agricultural Chemists, 1964 , vol. 47, p. 918,927 Full Text Show Details
Further information
Seiler; Wiechmann
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1964 , vol. 337, p. 229,231, 238 Full Text Show Details
Further information
ELSLAGER; WEINSTEIN; WORTH
Journal of medicinal chemistry, 1964 , vol. 7, p. 493 - 500 Title/Abstract Full Text View citing articles Show Details
Further information
Nace; King
Journal of Medicinal and Pharmaceutical Chemistry, 1962 , vol. 5, p. 1316,1321 Full Text Show Details
Further information
Kum-Tatt
Journal of Pharmacy and Pharmacology, 1960 , vol. 12, p. 666 Full Text Show Details
Further information
Brandstaetter-Kuhnert et al.
Scientia Pharmaceutica, 1960 , vol. 28, # 1 p. 7,8-15
Chem.Abstr., 1960 , # 17802 Full Text Show Details
Further information
Soc. Chim. Org. Biol.
Patent: FRM79 , 1960 ; Chem.Abstr., 1963 , vol. 58, # 10302g Full Text Show Details
Further information
Thomis; Kotionis
Analytica Chimica Acta, 1956 , vol. 14, p. 457 Chem.Abstr., 1957 , # 5624 Full Text View citing articles Show Details
Ionization Potential (1) Ionization Potential
Method (Ionization Potential)
Reference
10.17 eV
spectrographical
Meincke; Kottke; Beyrich
Pharmazie, 1992 , vol. 47, # 10 p. 780 - 783 Title/Abstract Full Text View citing articles Show Details
Liquid/Liquid Systems (MCS) (1) Description (Liquid/Liquid Systems (MCS))
Reference
Distribution between solvent 1 + 2
Beckett; Moffat
The Journal of pharmacy and pharmacology, 1969 , vol. 21, p. Suppl:144S+ Title/Abstract Full Text View citing articles Show Details
Mihailova; Testa
European Journal of Medicinal Chemistry, 1978 , vol. 13, # 1 p. 49 - 52 Title/Abstract Full Text View citing articles Show Details
Thies; Ermer
Naturwissenschaften, 1962 , vol. 49, p. 37 Full Text View citing articles Show Details
Donike; Iffland; Jaenicke
Arzneimittel-Forschung, 1974 , vol. 24, # 4 p. 556 - 560 Title/Abstract Full Text View citing articles Show Details
Mechanical & Physical Properties (MCS) (1) Description (Mechanical & Physical Properties (MCS))
Partner (Mechanical & Physical Properties (MCS))
Temperature (Mechanical & Physical Properties (MCS))
Partial molal volume
water
25 °C
Reference Shahidi, Fereidoon
Canadian Journal of Chemistry, 1987 , vol. 65, p. 1924 - 1926 Title/Abstract Full Text Show Details
Mechanical Properties (1) Description (Mechanical Properties)
Reference
Viscosity
Bloor; Morrinson
Journal of Pharmacy and Pharmacology, 1972 , vol. 24, p. 927,928,931,932 Full Text View citing articles Show Details
Optical Rotatory Dispersion (1) Reference Potapow; Terent'ew
J. Gen. Chem. USSR (Engl. Transl.), 1961 , vol. 31, p. 1003,927 Chem.Abstr., 1961 , # 23389 Full Text Show Details
Optical Rotatory Power (1) Type (Optical Rotatory Power)
Concentration (Optical Rotatory Power)
Solvent (Optical Rotatory Power)
Optical Rotatory Power
Wavelength (Optical Rotatory Power)
Temperature (Optical Rotatory Power)
[alpha]
10.62
ethanol
34.5 deg
589 nm
15 °C
Reference Yamada et al.
Tetrahedron Letters, 1976 , p. 1001
Full Text View citing articles Show Details
Partition octan-1-ol/water (MCS) (3) log POW
pH
Location
-0.63
7.4
supporting information
aq.buffer
Gunaydin, Hakan
ACS Medicinal Chemistry Letters, 2016 , vol. 7, # 1 p. 89 - 93 Title/Abstract Full Text View citing articles Show Details
1.76
supporting information
Gmez-Ros, Germn Augusto; Pawliszyn, Janusz
Angewandte Chemie - International Edition, 2014 , vol. 53, # 52 p. 14503 14507 Angew. Chem., 2014 , vol. 126, # 52 p. 14731 - 14735,5 Title/Abstract Full Text View citing articles Show Details
1.76
Huerta-Fontela, Maria; Galceran, Maria Teresa; Ventura, Francesc
Environmental Science and Technology, 2008 , vol. 42, # 18 p. 6809 - 6816 Title/Abstract Full Text View citing articles Show Details
Comment (Partition octan-1-ol/water (MCS))
Reference
Self-diffusion (1) Reference Bloor; Morrinson
Journal of Pharmacy and Pharmacology, 1972 , vol. 24, p. 927,928,931,932 Full Text View citing articles Show Details
Solubility (MCS) (1) Solubility
Saturation
Temperature (Solubility (MCS))
Solvent (Solubility (MCS))
0.0676045 g·l-1
in solution
25 °C
phosphate buffer
Reference
Alelyunas, Yun W.; Empfield, James R.; McCarthy, Dennis; Spreen, Russell C.; Bui, Khanh; Pelosi-Kilby, Luciana; Shen, Cindy
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 24 p. 7312 - 7316 Title/Abstract Full Text View citing articles Show Details
Vapour Pressure (1) Vapour Pressure
Temperature (Vapour Pressure)
Reference
0.26 Torr
26 °C
Steldt; Chen
Journal of the American Pharmaceutical Association (1912-1977), 1954 , vol. 43, p. 477,478 Full Text Show Details
Spectra NMR Spectroscopy (36) Description (NMR Spectroscopy)
Nucleus (NMR Spectroscopy)
Coupling Nuclei
Solvents (NMR Spectroscopy)
Frequency (NMR Spectroscopy)
Original Text (NMR Spectroscopy)
Chemical shifts Spectrum
1H
chloroform-d1
300 MHz
Chemical shifts Spectrum
13C
chloroform-d1
Chemical shifts
1H
chloroform-d1
Location
Reference
supporting information
Martínez-Montero, Lía; Díaz-Rodríguez, Alba; Gotor, Vicente; Gotor-Fernández, Vicente; Lavandera, Iván
Green Chemistry, 2015 , vol. 17, # 5 p. 2794 2798 Title/Abstract Full Text View citing articles Show Details
75 MHz
supporting information
Martínez-Montero, Lía; Díaz-Rodríguez, Alba; Gotor, Vicente; Gotor-Fernández, Vicente; Lavandera, Iván
Green Chemistry, 2015 , vol. 17, # 5 p. 2794 2798 Title/Abstract Full Text View citing articles Show Details
500 MHz
*H NMR (500 MHz, CDC13) δ
Page/Page column 66
ESS, Daniel, Halsell; FALCK, John, Russell; JAT, Jawahar, Lal; URTI, Laszlo
Chemical shifts
13C
chloroform-d1
126 MHz
8.46 (br s, 2H), 7.34-7.20 (m, 5H), 3.65-3.53 (m, 1H), 3.27 (dd, J= 13.4, 5.1 Hz, 1H), 2.87 (dd, J= 13.3, 9.1 Hz, 1H), 1.39 (d, J= 6.4 Hz, 3H);
13C
NMR (126 MHz, CDC13) δ 135.83, 129.35, 128.87, 127.26, 49.80, 41.07, 18.13.
Page/Page column 66
Patent: WO2015/103505 A2, 2015 ; Title/Abstract Full Text Show Details
ESS, Daniel, Halsell; FALCK, John, Russell; JAT, Jawahar, Lal; URTI, Laszlo
Patent: WO2015/103505 A2, 2015 ; Title/Abstract Full Text Show Details
Chemical shifts Spectrum
1H
chloroform-d1
400 MHz
supporting information
Poulhes, Florent; Vanthuyne, Nicolas; Bertrand, Michele P.; Gastaldi, Stephane; Gil, Gerard
Journal of Organic Chemistry, 2011 , vol. 76, # 17 p. 7281 - 7286 Title/Abstract Full Text View citing articles Show Details
Chemical shifts Spectrum
13C
chloroform-d1
75 MHz
supporting information
Poulhes, Florent; Vanthuyne, Nicolas; Bertrand, Michele P.; Gastaldi, Stephane; Gil, Gerard
Journal of Organic Chemistry, 2011 , vol. 76, # 17 p. 7281 - 7286 Title/Abstract Full Text View citing articles Show Details
DEPT (Distorsionless Enhancement by Polarisation Transfer) Chemical shifts Spectrum
13C
chloroform-d1
75 MHz
supporting information
Poulhes, Florent; Vanthuyne, Nicolas; Bertrand, Michele P.; Gastaldi, Stephane; Gil, Gerard
Journal of Organic Chemistry, 2011 , vol. 76, # 17 p. 7281 - 7286 Title/Abstract Full Text View citing articles Show Details
Chemical shifts
1H
chloroform-d1
400 MHz
supporting information
Imm, Sebastian; Neubert, Lorenz; Neumann, Helfried; Beller, Matthias
Angewandte Chemie - International Edition, 2010 , vol. 49, # 44 p. 8126 - 8129 Title/Abstract Full Text View citing articles Show Details
Munoz, Lourdes; Rodriguez, Anna M.; Rosell, Gloria; Bosch, M. Pilar; Guerrero, Angel
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 23 p. 8171 - 8177 Title/Abstract Full Text View citing articles Show Details
Chemical shifts
13C
chloroform-d1
100 MHz
supporting information
Imm, Sebastian; Neubert, Lorenz; Neumann, Helfried; Beller, Matthias
Angewandte Chemie - International Edition, 2010 , vol. 49, # 44 p. 8126 - 8129 Title/Abstract Full Text View citing articles Show Details
Munoz, Lourdes; Rodriguez, Anna M.; Rosell, Gloria; Bosch, M. Pilar; Guerrero, Angel
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 23 p. 8171 - 8177 Title/Abstract Full Text View citing articles Show Details
Chemical shifts
1H
chloroform-d1
300 MHz
Schulze, Matthias
Synthetic Communications, 2010 , vol. 40, # 10 p. 1461 - 1476 Title/Abstract Full Text View citing articles Show Details
Chemical shifts
13C
chloroform-d1
75 MHz
Schulze, Matthias
Synthetic Communications, 2010 , vol. 40, # 10 p. 1461 - 1476 Title/Abstract Full Text View citing articles Show Details
Chemical shifts
1H
dimethylsulfoxide-
300 MHz
Vahermo, Mikko; Suominen, Tina; Leinonen,
Chemical shifts
13C
Chemical shifts
Antti; Yli-Kauhaluoma, Jari
Archiv der Pharmazie, 2009 , vol. 342, # 4 p. 201 - 209 Title/Abstract Full Text View citing articles Show Details
d6
dimethylsulfoxided6
75 MHz
Vahermo, Mikko; Suominen, Tina; Leinonen, Antti; Yli-Kauhaluoma, Jari
Archiv der Pharmazie, 2009 , vol. 342, # 4 p. 201 - 209 Title/Abstract Full Text View citing articles Show Details
1H
300 MHz
Routaboul, Lucie; Vanthuyne, Nicolas; Gastaldi, Stephane; Gil, Gerard; Bertrand, Michele
Journal of Organic Chemistry, 2008 , vol. 73, # 2 p. 364 - 368 Title/Abstract Full Text View citing articles Show Details
Spectrum
13C
CDCl3
75 MHz
Nechab, Malek; Azzi, Nadia; Vanthuyne, Nicolas; Bertrand, Michele; Gastaldi, Stephane; Gil, Gerard
Journal of Organic Chemistry, 2007 , vol. 72, # 18 p. 6918 - 6923 Title/Abstract Full Text View citing articles Show Details
Routaboul, Lucie; Vanthuyne, Nicolas; Gastaldi, Stephane; Gil, Gerard; Bertrand, Michele
Journal of Organic Chemistry, 2008 , vol. 73, # 2 p. 364 - 368 Title/Abstract Full Text View citing articles Show Details
Chemical shifts
13C
CDCl3
75 MHz
Gyenes, Ferenc; Bergmann, Kathryn E.; Welch, John T.
Journal of Organic Chemistry, 1998 , vol. 63, # 9 p. 2824 - 2828 Title/Abstract Full Text View citing articles Show Details
Routaboul, Lucie; Vanthuyne, Nicolas; Gastaldi, Stephane; Gil, Gerard; Bertrand, Michele
Journal of Organic Chemistry, 2008 , vol. 73, # 2 p. 364 - 368 Title/Abstract Full Text View citing articles Show Details
Spectrum
1H
CDCl3
300 MHz
Nechab, Malek; Azzi, Nadia; Vanthuyne, Nicolas; Bertrand, Michele; Gastaldi, Stephane; Gil, Gerard
Journal of Organic Chemistry, 2007 , vol. 72, # 18 p. 6918 - 6923 Title/Abstract Full Text View citing articles Show Details
Chemical shifts
1H
CDCl3
400 MHz
Haak, Edgar; Siebeneicher, Holger; Doye, Sven
Organic Letters, 2000 , vol. 2, # 13 p. 1935 1937 Title/Abstract Full Text View citing articles Show Details
Viswanathan, Rajesh; Prabhakaran, Erode N.; Plotkin, Michael A.; Johnston, Jeffrey N.
Journal of the American Chemical Society, 2003 , vol. 125, # 1 p. 163 - 168 Title/Abstract Full Text View citing articles Show Details
Guisado, Cristina; Waterhouse, Jodie E.; Price, Wayne S.; Jorgensen, Michael R.; Miller, Andrew D.
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 6 p. 1049 - 1057 Title/Abstract Full Text View citing articles Show Details
1H
1H
CDCl3
400 MHz
Haak, Edgar; Siebeneicher, Holger; Doye, Sven
Organic Letters, 2000 , vol. 2, # 13 p. 1935 1937
Title/Abstract Full Text View citing articles Show Details
Viswanathan, Rajesh; Prabhakaran, Erode N.; Plotkin, Michael A.; Johnston, Jeffrey N.
Journal of the American Chemical Society, 2003 , vol. 125, # 1 p. 163 - 168 Title/Abstract Full Text View citing articles Show Details
Guisado, Cristina; Waterhouse, Jodie E.; Price, Wayne S.; Jorgensen, Michael R.; Miller, Andrew D.
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 6 p. 1049 - 1057 Title/Abstract Full Text View citing articles Show Details
Chemical shifts
13C
Description (NMR Spectroscopy)
Nucleus (NMR Spectroscopy)
Coupling Nuclei
Chemical shifts
1H
CDCl3
100 MHz
Haak, Edgar; Siebeneicher, Holger; Doye, Sven
Organic Letters, 2000 , vol. 2, # 13 p. 1935 1937 Title/Abstract Full Text View citing articles Show Details
Viswanathan, Rajesh; Prabhakaran, Erode N.; Plotkin, Michael A.; Johnston, Jeffrey N.
Journal of the American Chemical Society, 2003 , vol. 125, # 1 p. 163 - 168 Title/Abstract Full Text View citing articles Show Details
Guisado, Cristina; Waterhouse, Jodie E.; Price, Wayne S.; Jorgensen, Michael R.; Miller, Andrew D.
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 6 p. 1049 - 1057 Title/Abstract Full Text View citing articles Show Details
Hide facts Solvents (NMR Spectroscopy)
Temperature (NMR Spectroscopy)
Frequency (NMR Spectroscopy)
Comment (NMR Spectroscopy)
CDCl3
500 MHz
Li, Yanjun; Izumi, Taeko
Journal of the Chinese Chemical Society (Taipei, Taiwan), 2002 , vol. 49, # 4 p. 505 - 508 Title/Abstract Full Text View citing articles Show Details
Li, Yanjun; Izumi, Taeko
Journal of Chemical Research - Part S, 2003 , # 3 p. 128 - 129 Title/Abstract Full Text View citing articles Show Details
1H
1H
CDCl3
500 MHz
Li, Yanjun; Izumi, Taeko
Journal of the Chinese Chemical Society (Taipei, Taiwan), 2002 , vol. 49, # 4 p. 505 - 508 Title/Abstract Full Text View citing articles Show Details
Li, Yanjun; Izumi, Taeko
Journal of Chemical Research - Part S, 2003 , # 3 p. 128 - 129 Title/Abstract Full Text View citing articles Show Details
Chemical shifts
1H
D2O
26 °C
Thunhorst, Martin; Holzgrabe, Ulrike
Magnetic Resonance in Chemistry, 1998 , vol. 36, # 3 p. 211 - 216 Title/Abstract Full Text View citing articles Show Details
Chemical shifts
1H
CDCl3
300 MHz
Gyenes, Ferenc; Bergmann, Kathryn E.; Welch, John T.
Journal of Organic Chemistry, 1998 , vol. 63, # 9 p. 2824 - 2828 Title/Abstract Full Text View citing articles Show Details
1H
1H
CDCl3
300 MHz
Gyenes, Ferenc; Bergmann, Kathryn E.; Welch, John T.
Journal of Organic Chemistry, 1998 , vol. 63, # 9 p. 2824 - 2828 Title/Abstract Full Text View citing articles Show Details
Reference
Chemical shifts
13C
CDCl3
25 °C
Border, Corinne L.; Craik, David J.; Shehan, B. Philip
Magnetic Resonance in Chemistry, 1993 , vol. 31, # 3 p. 222 - 230 Title/Abstract Full Text Show Details
Spin-lattice relaxation time (T1)
Border, Corinne L.; Craik, David J.; Shehan, B. Philip
Magnetic Resonance in Chemistry, 1993 , vol. 31, # 3 p. 222 - 230 Title/Abstract Full Text Show Details
Chemical shifts
1H
Meincke; Kottke; Beyrich
Pharmazie, 1992 , vol. 47, # 9 p. 697 - 699 Title/Abstract Full Text View citing articles Show Details
Bell, Harold M.; Bowles, Deborah B.; Senese, Fred
Organic Magnetic Resonance, 1981 , vol. 16, # 4 p. 285 - 289 Title/Abstract Full Text Show Details
Chemical shifts
13C
CDCl3
Gee, Antony; Langstroem, Bengt
Acta Chemica Scandinavica, 1991 , vol. 45, # 4 p. 431 - 435 Title/Abstract Full Text Show Details
Chemical shifts
1H
CDCl3
Toda, Fumio; Mori, Koji; Okada, Jyoji; Node, Manabu; Itoh, Akichika; et al.
Chemistry Letters, 1988 , p. 131 - 134 Title/Abstract Full Text Show Details
Chemical shifts
1H
CCl4
El-Torki, Farid M.; Jacobus John
Journal of Organic Chemistry, 1985 , vol. 50, # 8 p. 1314 - 1316 Title/Abstract Full Text View citing articles Show Details
Spin-spin coupling constants
CCl4
1H-1H
El-Torki, Farid M.; Jacobus John
Journal of Organic Chemistry, 1985 , vol. 50, # 8 p. 1314 - 1316 Title/Abstract Full Text View citing articles Show Details
Spectrum
1H
CDCl3
24 °C
Ali, Abdel Rahman el Nasser Ossman
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 8 p. 762 - 765 Title/Abstract Full Text Show Details
NMR with shift reagents
Ali, Abdel Rahman el Nasser Ossman
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 8 p. 762 - 765 Title/Abstract Full Text Show Details
NMR
Landor et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1974 , p. 1294,1299 Full Text Show Details
Krieg
Arzneimittel-Forschung, 1974 , vol. 24, # 2 p. 133 - 134 Title/Abstract Full Text View citing articles Show Details
Smith et al.
Journal of Pharmaceutical Sciences, 1976 , vol. 65, p. 412,413, 414 Full Text View citing articles Show Details
Lambert et al.
Organic Magnetic Resonance, 1975 , vol. 7, p. 266,272 Full Text Show Details
Neville et al.
Journal of Medicinal Chemistry, 1971 , vol. 14, p. 717,718 Full Text Show Details
Lambert et al.
Spectroscopy Letters, 1975 , vol. 8, p. 509,511 Full Text Show Details
Spectrum
Fig. 1
Neville et al.
Journal of Medicinal Chemistry, 1971 , vol. 14, p. 717,718 Full Text Show Details
IR Spectroscopy (5) Description (IR Spectroscopy)
Solvent (IR Spectroscopy)
Bands
supporting information
film
Munoz, Lourdes; Rodriguez, Anna M.; Rosell, Gloria; Bosch, M. Pilar; Guerrero, Angel
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 23 p. 8171 - 8177 Title/Abstract Full Text View citing articles Show Details
Bands
potassium bromide
Vahermo, Mikko; Suominen, Tina; Leinonen, Antti; Yli-Kauhaluoma, Jari
Archiv der Pharmazie, 2009 , vol. 342, # 4 p. 201 - 209 Title/Abstract Full Text View citing articles Show Details
Bands
film
Viswanathan, Rajesh; Prabhakaran, Erode N.; Plotkin, Michael A.; Johnston, Jeffrey N.
Journal of the American Chemical Society, 2003 , vol. 125, # 1 p. 163 168 Title/Abstract Full Text View citing articles Show Details
Bands
neat (no solvent)
Gyenes, Ferenc; Bergmann, Kathryn E.; Welch, John T.
Journal of Organic Chemistry, 1998 , vol. 63, # 9 p. 2824 - 2828 Title/Abstract Full Text View citing articles Show Details
Haak, Edgar; Siebeneicher, Holger; Doye, Sven
Organic Letters, 2000 , vol. 2, # 13 p. 1935 - 1937 Title/Abstract Full Text View citing articles Show Details
IR
Blang; Huang
Journal of Pharmaceutical Sciences, 1972 , vol. 61, p. 1770,1772, 1774 Full Text View citing articles Show Details
Location
Comment (IR Spectroscopy)
Reference
Mass Spectrometry (28) Description (Mass Spectrometry)
Location
Reference
tandem mass spectrometry CID (collision-induced dissociation) spectrum
Damon, Deidre E.; Davis, Kathryn M.; Moreira, Camila R.; Capone, Patricia; Cruttenden, Riley; BaduTawiah, Abraham K.
Analytical Chemistry, 2016 , vol. 88, # 3 p. 1878 - 1884 Title/Abstract Full Text View citing articles Show Details
high resolution mass spectrometry (HRMS) spectrum
Duvivier, Wilco F.; Van Putten, Marc R.; Van Beek, Teris A.; Nielen, Michel W. F.
Analytical Chemistry, 2016 , vol. 88, # 4 p. 2489 - 2496 Title/Abstract Full Text View citing articles Show Details
APCI (atmospheric pressure chemical ionization) tandem mass spectrometry spectrum
Crevelin, Eduardo J.; Salami, Fernanda H.; Alves, Marcela N. R.; De Martinis, Bruno S.; Crotti, Antônio E. M.; Moraes, Luiz A. B.
Journal of the American Society for Mass Spectrometry, 2016 , vol. 27, # 5 p. 944 - 947 Title/Abstract Full Text View citing articles Show Details
electrospray ionisation (ESI) spectrum
Badu-Tawiah, Abraham; Cooks, R. Graham
Journal of the American Society for Mass Spectrometry, 2010 , vol. 21, # 8 p. 1423 - 1431 Title/Abstract Full Text View citing articles Show Details
Jeong, Eun Sook; Kim, So-Hee; Cha, Eun-Ju; Lee, Kang Mi; Kim, Ho Jun; Lee, Sang-Won; Kwon, OhSeung; Lee, Jaeick
Rapid Communications in Mass Spectrometry, 2015 , vol. 29, # 4 p. 367 - 384 Title/Abstract Full Text View citing articles Show Details
liquid chromatography mass spectrometry (LCMS) electrospray ionisation (ESI) spectrum
Jeong, Eun Sook; Kim, So-Hee; Cha, Eun-Ju; Lee, Kang Mi; Kim, Ho Jun; Lee, Sang-Won; Kwon, OhSeung; Lee, Jaeick
Rapid Communications in Mass Spectrometry, 2015 , vol. 29, # 4 p. 367 - 384 Title/Abstract Full Text Show Details
APCI (atmospheric pressure chemical ionization) spectrum
supporting information
Martínez-Montero, Lía; Díaz-Rodríguez, Alba; Gotor, Vicente; Gotor-Fernández, Vicente; Lavandera, Iván
Green Chemistry, 2015 , vol. 17, # 5 p. 2794 - 2798 Title/Abstract Full Text View citing articles Show Details
spectrum
Haak, Edgar; Siebeneicher, Holger; Doye, Sven
Organic Letters, 2000 , vol. 2, # 13 p. 1935 - 1937 Title/Abstract Full Text View citing articles Show Details
Espy, Ryan D.; Teunissen, Sebastiaan Frans; Manicke, Nicholas E.; Ren, Yue; Ouyang, Zheng; Van Asten, Arian; Cooks, R. Graham
Analytical Chemistry, 2014 , vol. 86, # 15 p. 7712 - 7718 Title/Abstract Full Text View citing articles Show Details
liquid chromatography mass spectrometry (LCMS) CID (collision-induced dissociation) spectrum
Lin, Huei-Ru; Liao, Chao-Chuan; Lin, Tzu-Chieh
Rapid Communications in Mass Spectrometry, 2014 , vol. 28, # 19 p. 2043 - 2053 Title/Abstract Full Text View citing articles Show Details
high resolution mass spectrometry (HRMS) liquid chromatography mass spectrometry (LCMS) time-of-flight mass spectra (TOFMS) tandem mass spectrometry spectrum
Roemmelt, Andreas T.; Steuer, Andrea E.; Poetzsch, Michael; Kraemer, Thomas
Analytical Chemistry, 2014 , vol. 86, # 23 p. 11742 - 11749 Title/Abstract Full Text View citing articles Show Details
liquid chromatography mass spectrometry (LCMS) electrospray ionisation (ESI) tandem mass spectrometry spectrum
Spinner; Klima; Kempf; Huppertz; Auwärter; Altenburger; Neukamm
Journal of Mass Spectrometry, 2014 , vol. 49, # 12 p. 1306 - 1313 Title/Abstract Full Text View citing articles Show Details
tandem mass spectrometry spectrum
supporting information
Gmez-Ros, Germn Augusto; Pawliszyn, Janusz
Angewandte Chemie - International Edition, 2014 , vol. 53, # 52 p. 14503 - 14507 Angew. Chem., 2014 , vol. 126, # 52 p. 14731 - 14735,5 Title/Abstract Full Text View citing articles Show Details
tandem mass spectrometry electrospray ionisation (ESI) high resolution mass spectrometry (HRMS) spectrum
Fedorova, Ganna; Randak, Tomas; Lindberg, Richard H.; Grabic, Roman
Rapid Communications in Mass Spectrometry, 2013 , vol. 27, # 15 p. 1751 - 1762 Title/Abstract Full Text View citing articles Show Details
electrospray ionisation (ESI) high resolution mass spectrometry (HRMS) spectrum
Fedorova, Ganna; Randak, Tomas; Lindberg, Richard H.; Grabic, Roman
Rapid Communications in Mass Spectrometry, 2013 , vol. 27, # 15 p. 1751 - 1762 Title/Abstract Full Text View citing articles Show Details
Tandem mass spectrometry TOFMS (Time of flight mass spectrum) ESI (Electrospray ionisation) Spectrum
Bijlsma, Lubertus; Sancho, Juan V.; Hernandez, Felix; Niessen, Wilfried M.A.
Journal of Mass Spectrometry, 2011 , vol. 46, # 9 p. 865 - 875 Title/Abstract Full Text View citing articles Show Details
EI (Electron impact) Spectrum
supporting information
Munoz, Lourdes; Rodriguez, Anna M.; Rosell, Gloria; Bosch, M. Pilar; Guerrero, Angel
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 23 p. 8171 - 8177 Title/Abstract Full Text View citing articles Show Details
ESI (Electrospray ionisation) Tandem mass spectrometry Spectrum
Liu, Ying; Uboh, Cornelius E.; Soma, Lawrence R.; Li, Xiaoqing; Guan, Fuyu; You, Youwen; Chen, JinWen
Analytical Chemistry, 2011 , vol. 83, # 17 p. 6834 - 6841 Title/Abstract Full Text View citing articles Show Details
EI (Electron impact) GCMS (Gas chromatography mass spectrometry) Spectrum
supporting information
Imm, Sebastian; Neubert, Lorenz; Neumann, Helfried; Beller, Matthias
Angewandte Chemie - International Edition, 2010 , vol. 49, # 44 p. 8126 - 8129 Title/Abstract Full Text View citing articles Show Details
HRMS (High resolution mass spectrometry) ESI (Electrospray ionisation) LCMS (Liquid chromatography mass spectrometry) TOFMS (Time of flight mass spectrum) Spectrum
supporting information
Imm, Sebastian; Neubert, Lorenz; Neumann, Helfried; Beller, Matthias
Angewandte Chemie - International Edition, 2010 , vol. 49, # 44 p. 8126 - 8129 Title/Abstract Full Text View citing articles Show Details
HRMS (High resolution mass spectrometry) TOFMS (Time of flight mass spectrum) ESI (Electrospray ionisation) LCMS (Liquid chromatography mass spectrometry)
Vonaparti; Lyris; Angelis; Panderi; Koupparis; Tsantili-Kakoulidou; Peters; Nielen; Georgakopoulos
Rapid Communications in Mass Spectrometry, 2010 , vol. 24, # 11 p. 1595 - 1609 Title/Abstract Full Text View citing articles Show Details
Spectrum LCMS (Liquid chromatography mass spectrometry) IT (ion trap) Tandem mass spectrometry Spectrum
Lee, Sang Kyu; Kim, So-Hee; Kim, Ho Jun; Yoo, Hye Hyun; Kwon, Oh Seung; In, Moon Kyo; Jin, Changbae; Kim, Dong Hyun; Lee, Jaeick
Rapid Communications in Mass Spectrometry, 2010 , vol. 24, # 21 p. 3139 - 3145 Title/Abstract Full Text View citing articles Show Details
Hide facts Description (Mass Spectrometry)
Comment (Mass Spectrometry)
APCI (atmospheric pressure chemical ionization) Spectrum
Inoue, Hiroyuki; Hashimoto, Hiroaki; Watanabe, Susumu; Iwata, Yuko T.; Kanamori, Tatsuyuki; Miyaguchi, Hajime; Tsujikawa, Kenji; Kuwayama, Kenji; Tachi, Noriyuki; Uetake, Naohito
Journal of Mass Spectrometry, 2009 , vol. 44, # 9 p. 1300 - 1307 Title/Abstract Full Text View citing articles Show Details
APCI (atmospheric pressure chemical ionization) Tandem mass spectrometry Spectrum
Inoue, Hiroyuki; Hashimoto, Hiroaki; Watanabe, Susumu; Iwata, Yuko T.; Kanamori, Tatsuyuki; Miyaguchi, Hajime; Tsujikawa, Kenji; Kuwayama, Kenji; Tachi, Noriyuki; Uetake, Naohito
Journal of Mass Spectrometry, 2009 , vol. 44, # 9 p. 1300 - 1307 Title/Abstract Full Text View citing articles Show Details
LCMS (Liquid chromatography mass spectrometry) ESI (Electrospray ionisation) Tandem mass spectrometry Spectrum
mol peak
Thoerngren, John-Olof; Oestervall, Fredrik; Garle, Mats
Journal of Mass Spectrometry, 2008 , vol. 43, # 7 p. 980 - 992 Title/Abstract Full Text View citing articles Show Details
spectrum tandem mass spectrometry
Pihlainen, Katja; Grigoras, Kestutis; Franssila, Sami; Ketola, Raimo; Kotiaho, Tapio; Kostiainen, Risto
Journal of Mass Spectrometry, 2005 , vol. 40, # 4 p. 539 - 545 Title/Abstract Full Text View citing articles Show Details
positive secondary ions
Zappey, Herman; Fokkens, Roel H.; Ingemann, Steen; Nibbering, Nico M. M.; Florencio, Helena
Organic Mass Spectrometry, 1991 , vol. 26, # 6 p. 587 - 594 Title/Abstract Full Text Show Details
fragmentation pattern spectrum electron impact (EI)
Zappey, Herman; Fokkens, Roel H.; Ingemann, Steen; Nibbering, Nico M. M.; Florencio, Helena
Organic Mass Spectrometry, 1991 , vol. 26, # 6 p. 587 - 594 Title/Abstract Full Text Show Details
chemical ionization (CI) spectrum
collisional activation
Todd; Stafford Jr.; Kelley; Syka; Cooks; Louris
Analytical Chemistry, 1987 , vol. 59, # 13 p. 1677 - 1685 Title/Abstract Full Text View citing articles Show Details
Coutts; Jones; Liu
Biomedical Mass Spectrometry, 1978 , vol. 5, # 6 p. 418 - 422 Title/Abstract Full Text View citing articles Show Details
Milne et al.
Analytical Chemistry, 1971 , vol. 43, p. 1815,1817 Full Text Show Details
Reisch et al.
Journal of Pharmacy and Pharmacology, 1968 , vol. 20, p. 81,85 Full Text Show Details
Hunneman
Chemiker-Zeitung, 1974 , vol. 98, p. 28,32 Full Text Show Details
Brandenberger
Pharmaceutica Acta Helvetiae, 1970 , vol. 45, p. 394,406 Full Text Show Details
Arsenault et al.
Analytical Chemistry, 1971 , vol. 43, p. 1720 Full Text View citing articles Show Details
Serck-Hanssen
Archives of Mass Spectral Data, 1971 , vol. 2, p. 760 Full Text Show Details
Cartoni et al.
Bollettino Chimico Farmaceutico, 1976 , vol. 115, p. 347,350 Full Text Show Details
Kamei et al.
Chemical and Pharmaceutical Bulletin, 1973 , vol. 21, p. 1996,2000 Full Text Show Details
Beckett et al.
Journal of Pharmacy and Pharmacology, 1967 , vol. 19, p. 273,291 Full Text Show Details
UV/VIS Spectroscopy (8)
Reference
Description (UV/VIS Spectroscopy)
Solvent (UV/VIS Spectroscopy)
Comment (UV/VIS Spectroscopy)
Spectrum
Predmore; Christian
Analytical chemistry, 1976 , vol. 48, # 2 p. 361 - 363 Title/Abstract Full Text View citing articles Show Details
Furman
Journal - Association of Official Analytical Chemists, 1968 , vol. 51, p. 1111,1115 Full Text Show Details
Ruckpaul et al.
Croatica Chemica Acta, 1977 , vol. 49, p. 339,343 Full Text Show Details
Blasco-Gomez; Bosch-Reig; Campins-Falco; Molins-Legua; Herraez-Hernandez
Analytical Chemistry, 2000 , vol. 72, # 11 p. 2559 - 2565 Title/Abstract Full Text View citing articles Show Details
UV/VIS
Blang; Huang
Journal of Pharmaceutical Sciences, 1972 , vol. 61, p. 1770,1772, 1774 Full Text View citing articles Show Details
Bloor; Morrinson
Journal of Pharmacy and Pharmacology, 1972 , vol. 24, p. 927,928,931,932 Full Text View citing articles Show Details
Spectrum
CHCl3
240 - 280 nm
Rontondaro
Journal of the Association of Official Agricultural Chemists, 1957 , vol. 40, p. 824,827 Full Text Show Details
Spectrum
aq. H2SO4
230 - 280 nm
Rontondaro
Journal of the Association of Official Agricultural Chemists, 1957 , vol. 40, p. 824,827 Full Text Show Details
Spectrum
ethanol
240 - 300 nm
FREEMAN
Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1953 , vol. 42, # 10 p. 621 - 622 Title/Abstract Full Text View citing articles Show Details
Spectrum
ethanol
245 - 270 nm
EBSTEIN; VAN METER
Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1952 , vol. 41, # 7 p. 372 - 374 Title/Abstract Full Text View citing articles Show Details
Spectrum
diethyl ether
245 - 270 nm
EBSTEIN; VAN METER
Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1952 , vol. 41, # 7 p. 372 - 374 Title/Abstract Full Text View citing articles Show Details
Spectrum
CHCl3
245 - 270 nm
EBSTEIN; VAN METER
Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1952 , vol. 41, # 7 p. 372 - 374 Title/Abstract Full Text View citing articles Show Details
Reference
Raman Spectroscopy (1) Description (Raman Spectroscopy)
Reference
Raman
West, Matthew J.; Went, Michael J.
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2009 , vol. 71, # 5 p. 1984 - 1988 Title/Abstract Full Text View citing articles Show Details
Fluorescence Spectroscopy (2) Description (Fluorescence Spectroscopy)
Comment (Fluorescence Spectroscopy)
Reference
Spectrum
267.02 - 265.25 nm
Sun; Bernstein
Journal of the American Chemical Society, 1996 , vol. 118, # 21 p. 5086 - 5095 Title/Abstract Full Text View citing articles Show Details
Fluorescence
Lindenbaum et al.
Journal of the Chemical Society, Chemical Communications, 1977 , p. 268 Full Text View citing articles Show Details
Smythies et al.
Experientia, 1971 , vol. 27, p. 62,63 Full Text Show Details
Phosphorescence Spectroscopy (1)
Description (Phosphorescence Spectroscopy)
Reference
Phosphorescence
Harbaugh et al.
Analytical Chemistry, 1974 , vol. 46, p. 1206 Full Text View citing articles Show Details
Bioactivity Pharmacological Data (317) 1 of 317
Comment (Pharmacological Data)
Bioactivities present
Reference
Cervinka,O. et al.
Collection of Czechoslovak Chemical Communications, 1968 , vol. 33, p. 3551 - 3557 Full Text View citing articles Show Details
Iwai; Tomita; Ide
Chemical and pharmaceutical bulletin, 1965 , vol. 13, # 2 p. 118 - 129 Title/Abstract Full Text View citing articles Show Details
Syva Company
Patent: US3966744 A1, 1976 ; Title/Abstract Full Text Show Details
Laboratoires Laroche Navarron
Patent: US3979456 A1, 1976 ; Title/Abstract Full Text Show Details
Sciortino; Du Ban
Bollettino chimico farmaceutico, 1968 , vol. 107, # 8 p. 506 - 511 Title/Abstract Full Text View citing articles Show Details
Collino
Bollettino chimico farmaceutico, 1969 , vol. 108, # 6 p. 355 - 367 Title/Abstract Full Text View citing articles Show Details
Dalla Vedova; D'Alo
Bollettino Chimico Farmaceutico, 1973 , vol. 112, # 4 p. 273 - 282 Title/Abstract Full Text View citing articles Show Details
E. R. Squibb and Sons, Inc.
Patent: US4131744 A1, 1978 ; Title/Abstract Full Text Show Details
Pesin,V.G.; D'yachenko,S.A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1969 , vol. 5, p. 453 - 456 Khimiya Geterotsiklicheskikh Soedinenii, 1969 , vol. 5, # 4 p. 613 - 618 Full Text View citing articles Show Details
O'Connor,M.J. et al.
Journal of the American Chemical Society, 1968 , vol. 90, p. 1744 - 1752 Full Text View citing articles Show Details
Gerlach,D.H.; Holm,R.H.
Journal of the American Chemical Society, 1969 , vol. 91, p. 3457 - 3467 Full Text View citing articles Show Details
Sumitomo Chemical Company, Limited
Patent: US4698421 A1, 1987 ; Title/Abstract Full Text Show Details
Herlinger,H. et al.
Justus Liebigs Annalen der Chemie, 1967 , vol. 706, p. 37 - 46 Full Text View citing articles Show Details
Kindler,K.; Luehrs,K.
Justus Liebigs Annalen der Chemie, 1967 , vol. 707, p. 26 - 34 Full Text View citing articles Show Details
BURGER; STANDRIDGE; ARIENS
Journal of medicinal chemistry, 1963 , vol. 6, p. 221 - 227 Title/Abstract Full Text View citing articles Show Details
ELSLAGER; WEINSTEIN; WORTH
Journal of medicinal chemistry, 1964 , vol. 7, p. 493 - 500 Title/Abstract Full Text View citing articles Show Details
Burger; Zimmerman; Ariens
Journal of medicinal chemistry, 1966 , vol. 9, # 4 p. 469 - 470 Title/Abstract Full Text View citing articles Show Details
Rubinstein; Elming; Fakstorp; Hermansen; Pedersen; Jacobsen
Journal of medicinal chemistry, 1966 , vol. 9, # 6 p. 804 - 809 Title/Abstract Full Text View citing articles Show Details
Gringauz,A.
Journal of Medicinal Chemistry, 1968 , vol. 11, p. 611 - 612 Full Text View citing articles Show Details
Howe; Crowther; Stephenson; Rao; Smith
Journal of medicinal chemistry, 1968 , vol. 11, # 5 p. 1000 - 1008 Title/Abstract Full Text View citing articles Show Details
2 of 317
Comment (Pharmacological Data)
Bioactivities present
Reference
Trepanier; Shriver; Eble
Journal of medicinal chemistry, 1969 , vol. 12, # 2 p. 257 - 260 Title/Abstract Full Text View citing articles Show Details
Howe; McLoughlin; Rao; Smith; Chodnekar
Journal of medicinal chemistry, 1969 , vol. 12, # 3 p. 452 - 458 Title/Abstract Full Text View citing articles Show Details
Kaiser; Leonard; Heil; Lester; Tedeschi; Zirkle
Journal of medicinal chemistry, 1970 , vol. 13, # 5 p. 820 - 826 Title/Abstract Full Text View citing articles Show Details
Verbiscar,A.J.; Abood,L.G.
Journal of Medicinal Chemistry, 1970 , vol. 13, p. 1176 - 1179 Full Text View citing articles Show Details
Shadbolt; Sharpe; Brown; Ashford; Ross
Journal of medicinal chemistry, 1971 , vol. 14, # 9 p. 836 - 842 Title/Abstract Full Text View citing articles Show Details
Rastogi; Anand; Prasad
Journal of medicinal chemistry, 1972 , vol. 15, # 3 p. 286 - 291 Title/Abstract Full Text View citing articles Show Details
Horgan,S.W. et al.
Journal of Medicinal Chemistry, 1975 , vol. 18, p. 315 - 318 Full Text View citing articles Show Details
Najjar; Blake; Benoit; Lu
Journal of Medicinal Chemistry, 1978 , vol. 21, # 6 p. 555 - 558 Title/Abstract Full Text View citing articles Show Details
Schulz,H.
Pharmazie, 1967 , vol. 22, p. 19 - 22 Full Text View citing articles Show Details
Schulz
Die Pharmazie, 1968 , vol. 23, # 5 p. 240 - 242 Title/Abstract Full Text View citing articles Show Details
Reisch; Alfes; Kommert; Jantos; Moellmann; Clasing
Die Pharmazie, 1970 , vol. 25, # 5 p. 331 - 334 Title/Abstract Full Text View citing articles Show Details
Schulz; Jassmann; Bekker
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Comment (Pharmacological Data)
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Comment (Pharmacological Data)
Bioactivities present
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Comment (Pharmacological Data)
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MEMORY PHARMACEUTICALS CORPORATION
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NOVARTIS AG; NOVARTIS PHARMA GMBH
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PFIZER PRODUCTS INC.
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DESCARTES THERAPEUTICS, INC.
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IRM LLC
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Novo Nordisk, A/S
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MOUNT SINAI SCHOOL OF MEDICINE
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ABBOTT GMBH and CO.KG
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CENGENT THERAPEUTICS, INC.
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CLERA INC.
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THE SILVAN S. TOMKINS INSTITUTE
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The Research Foundation of the City University of New York; New York University
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Kulli, John C.
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LABORATORIOS DEL DR. ESTEVE, S.A.
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Laboratorios del Dr. Esteve S.A.
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LABORATORIOS DEL DR. ESTEVE, S.A.
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LABORATORIOS DEL DR. ESTEVE, S.A.
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Cypress Bioscience, Inc.
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NOVARTIS AG; NOVARTIS PHARMA GmbH
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IRM LLC
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IRM LLC
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Comment (Pharmacological Data)
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Wyeth
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Wyeth
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GELESIS, INC.
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Nettekoven, Matthias Heinrich; Roche, Olivier
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NOVO NORDISK A/S
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GOUAUX, ERIC; SONG, Langzhou; XIE, Yuli; LANDRY, Donald W.
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NOVO NORDISK A/S
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Korea Institute of Science and Technology
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Jhamandas, Khem; Milne, Brian
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Nettekoven, Matthias; Roche, Olivier
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CYPRESS BIOSCIENCE, INC.
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THE UNIVERSITY OF MONTANA
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Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
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Hebeisen, Paul; Roever, Stephan
Patent: US2008/70931 A1, 2008 ; Title/Abstract Full Text Show Details
Poestges, Reiner; Schneider, Bernd; Ammer, Richard
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THERAQUEST BIOSCIENCES, INC.
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BRAINCELLS, INC.
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Tam, Peter Y.; Wilson, Leland F.
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Erne; Ramirez
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Comment (Pharmacological Data)
Bioactivities present
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Miles Labor. Inc.
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Am. Home Prod. Corp.
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Lepetit S.p.A.
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Wasil'ewa; Jaschunskii
Khimicheskaya Nauka i Promyshlennost, 1959 , vol. 4, p. 678 Chem.Abstr., 1960 , p. 8793 Full Text Show Details
DAT XUONG
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Kiprianow; Chrapal
Ukrainskii Khimicheskii Zhurnal (Russian Edition), 1950 , vol. 16, # 6 p. 632,634 Chem.Abstr., 1954 , p. 10 635 Full Text Show Details
Fusco; Canonica
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Comment (Pharmacological Data)
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Reference
Haskelberg
Journal of the American Chemical Society, 1948 , vol. 70, p. 2811 Full Text View citing articles Show Details
Bras; Skorodumow
Doklady Akademii Nauk SSSR, 1948 , vol. 59, p. 491 Chem.Abstr., 1948 , vol. 42, p. 6747 Full Text Show Details
Shapiro et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 6060,6063 Journal of the American Chemical Society, 1959 , vol. 81, p. 203,207 Full Text Show Details
Kiprianow; Frenkel
Ukrainskii Khimicheskii Zhurnal (Russian Edition), 1950 , vol. 16, p. 620,625 Chem.Abstr., 1954 , p. 10635 Full Text Show Details
Blicke; Lilienfeld
Journal of the American Chemical Society, 1943 , vol. 65, p. 2377 Full Text View citing articles Show Details
Stevenson; Williamson
Journal of the American Chemical Society, 1958 , vol. 80, p. 5943,5946 Full Text Show Details
Am.Home Prod.Corp.
Patent: US2654754 , 1950 ; Full Text Show Details
Karrer; Ehrhardt
Helvetica Chimica Acta, 1951 , vol. 34, p. 2202,2208 Full Text Show Details
Hey
Journal of the Chemical Society, 1930 , p. 18,20 Full Text Show Details
Wanag; Veinbergs
Chemische Berichte, 1942 , vol. 75, p. 1558,1567 Full Text Show Details
King et al.
Journal of the Chemical Society, 1954 , p. 1044 Full Text Show Details
Stawrowskaja
Zhurnal Obshchei Khimii, 1955 , vol. 25, p. 193,197;engl.Ausg.S.177,180 Full Text Show Details
Biel et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 2805,2810, 2813 Full Text View citing articles Show Details
Calo; Evdokimoff
Gazzetta Chimica Italiana, 1950 , vol. 80, p. 456,460 Full Text Show Details
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Sb. Statei Obshch. Khim., 1953 , p. 714 Chem.Abstr., 1955 , p. 1072 Full Text Show Details
Machek
Monatshefte fuer Chemie, 1939 , vol. 72, p. 77,88 Full Text Show Details
Chiavarelli et al.
Gazzetta Chimica Italiana, 1957 , vol. 87, p. 427,436 Full Text Show Details
Machek
Monatshefte fuer Chemie, 1941 , vol. 73, p. 180,183, 184 Full Text View citing articles Show Details
Shriner; Child
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Crum; Robinson
Journal of the Chemical Society, 1943 , p. 561,562 Full Text Show Details
10 of 317
Comment (Pharmacological Data)
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Reference
Harlay
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1941 , vol. 213, p. 304 Full Text Show Details
Comm.Solv.Corp.
Patent: US2636901 , 1949 ; Full Text Show Details
Mastagli et al.
Bulletin de la Societe Chimique de France, 1950 , p. 1045 Full Text Show Details
Najer et al.
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Ratschinskii et al.
Zhurnal Obshchei Khimii, 1958 , vol. 28, p. 2998,3001,3002;engl.Ausg.S.3027,3028,3030 Full Text Show Details
Sekiya
Yakugaku Zasshi, 1950 , vol. 70, p. 553 Chem.Abstr., 1951 , p. 5619 Full Text Show Details
Cannon et al.
Journal of Organic Chemistry, 1957 , vol. 22, p. 1323,1325 Full Text Show Details
Hass et al.
Journal of Organic Chemistry, 1950 , vol. 15, p. 8,13 Full Text Show Details
Patrick; McBee; Hass
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Alles
Journal of the American Chemical Society, 1932 , vol. 54, p. 271,273 Full Text Show Details
Couturier
Annales de Chimie (Cachan, France), 1938 , vol. <11> 10, p. 559,597 Full Text Show Details
Shapiro et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 5646,5648 Full Text Show Details
Kieffer; Rumpf
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1950 , vol. 230, p. 2302 Full Text Show Details
Alexander; Misegades
Journal of the American Chemical Society, 1948 , vol. 70, p. 1315 Full Text View citing articles Show Details
Bobranskii; Drabik
Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1941 , vol. 14, p. 410,413 Chem.Abstr., 1942 , p. 2531 Full Text Show Details
Magidson; Garkuscha
Zhurnal Obshchei Khimii, 1941 , vol. 11, p. 339,341 Chem.Abstr., 1941 , p. 5868 Full Text Show Details
FREEMAN
Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1953 , vol. 42, # 10 p. 621 - 622 Title/Abstract Full Text View citing articles Show Details
Edeleanu
Chemische Berichte, 1887 , vol. 20, p. 618 Full Text Show Details
Leithe
Chemische Berichte, 1932 , vol. 65, p. 660,665 Full Text Show Details
Zenitz; Macks; Moore
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Comment (Pharmacological Data)
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Reference
Kindler; Hedemann; Schaerfe
Justus Liebigs Annalen der Chemie, 1948 , vol. 560, p. 215,219 Full Text Show Details
Hartung; Munch
Journal of the American Chemical Society, 1931 , vol. 53, p. 1875,1878 Full Text Show Details
Jaeger; van Dijk
Proceedings of the Koninklijke Nederlandse Akademie van Wetenschappen, Series B: Physical Sciences, 1941 , vol. 44, p. 26,36,37 Full Text Show Details
Potapow; Terentew
Zhurnal Obshchei Khimii, 1958 , vol. 28, p. 3323,3325 Anm.
J. Gen. Chem. USSR (Engl. Transl.), 1958 , vol. 28, p. 3349,3351 Anm. Full Text Show Details
Hald; Gad
Dansk Tidsskrift for Farmaci, 1938 , vol. 12, p. 97,103 Full Text Show Details
Woodruff; Conger
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Jaeger; van Dijk
Proceedings of the Koninklijke Nederlandse Akademie van Wetenschappen, Series B: Physical Sciences, 1941 , vol. 71, p. 26,27 Full Text Show Details
Kay-Fries Chem.Inc.
Patent: US2413493 , 1941 ; Full Text Show Details
Vargha; Gyoerffy
Magyar chem.FolyoiratChem.Abstr., 1944 , vol. 50, p. 6,8 Magyar chem.FolyoiratChem.Abstr., 1948 , p. 1219 Full Text Show Details
Purdue Research Found
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Woodruff; Lambooy; Burt
Journal of the American Chemical Society, 1940 , Full Text View citing articles Show Details
Larsson
Svensk Kemisk Tidskrift, 1949 , vol. 61, p. 59 Full Text Show Details
Patrick; McBee; Hass
Journal of the American Chemical Society, 1946 , Full Text View citing articles Show Details
Ritter; Kalish
Journal of the American Chemical Society, 1948 , Organic Syntheses, 1964 , vol. 44, p. 44,45 Full Text View citing articles Show Details
Kornblum; Iffland
Journal of the American Chemical Society, 1949 , Full Text View citing articles Show Details
Buth; Kuelz; Rosenmund
Chemische Berichte, 1939 , vol. 72, p. 19,28 Full Text Show Details
Wyeth Inc.
Patent: US2449638 , 1946 ;
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Kralt et al.
Recueil des Travaux Chimiques des Pays-Bas, 1958 , vol. 77, p. 177,183 Full Text Show Details
FISCHER; PLEIN
Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1955 , vol. 44, # 5 p. 313 - 316 Title/Abstract Full Text View citing articles Show Details
Chiavarelli; Marini Bettolo
Gazzetta Chimica Italiana, 1951 , vol. 81, p. 89,92 Full Text Show Details
12 of 317
Comment (Pharmacological Data)
Bioactivities present
Reference
Rapp; Kornew
Ukrainskii Khimicheskii Zhurnal (Russian Edition), 1957 , vol. 23, p. 637,639 Ukrainskii Khimicheskii Zhurnal (Russian Edition), 1959 , vol. 25, p. 351 Chem.Abstr., 1958 , p. 9979,1960 1368 Full Text Show Details
Rebstock et al.
Journal of the American Chemical Society, 1951 , vol. 73, p. 3666,3670 Full Text Show Details
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Lewis
British Journal of Pharmacology and Chemotherapy, 1954 , vol. 9, p. 488,490 Full Text Show Details
Pratesi; La Manna
Farmaco, Edizione Scientifica, 1956 , vol. 11, p. 33,41 Full Text Show Details
Murakami; Akagi
Nippon Kagaku Zasshi, 1954 , vol. 75, p. 532,534 Chem.Abstr., 1957 , p. 11242 Full Text Show Details
EBSTEIN; VAN METER
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Steldt; Chen
Journal of the American Pharmaceutical Association (1912-1977), 1954 , vol. 43, p. 477,478
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Wilson
Org.Synth.Isotopes, 1958 , p. 512 Full Text Show Details
Temmler-Werke
Patent: DE767186 , 1937 ; DRP/DRBP Org.Chem. Full Text Show Details
Miles Labor.Inc.
Patent: US2797243 , 1953 ; Full Text Show Details
Smith,Kline and French Labor.
Patent: US2608583 , 1949 ; Full Text Show Details
Temmler-Werke
Patent: DE870265 , 1941 ; Full Text Show Details
Larsson
Chalmers Handl., 1950 , # 94 p. 21,26 Full Text Show Details
BASF
Patent: DE848197 , 1944 ; DRP/DRBP Org.Chem. Full Text Show Details
Chatten; Levi
Analytical Chemistry, 1959 , vol. 31, p. 1581,1582,1585 Full Text View citing articles Show Details
Temmler-Werke
Patent: DE871155 , 1938 ; Full Text Show Details
Simon
Zhurnal Obshchei Khimii, 1958 , vol. 28, p. 2586;engl.Ausg.S.2619 Full Text Show Details
Temmler-Werke
Patent: DE865599 , 1943 ; Full Text Show Details
Kiprianow; Molewa
Ukrainskii Khimicheskii Zhurnal (Russian Edition), 1953 , vol. 19, p. 418 Chem.Abstr., 1955 , p. 8146 Full Text Show Details
13 of 317
Comment (Pharmacological Data)
Bioactivities present
Reference
Smith, Kline and French Labor.
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Kiprianow; Chrapal
Ukrainskii Khimicheskii Zhurnal (Russian Edition), 1950 , vol. 16, p. 627,629 Chem.Abstr., 1954 , p. 10635 Full Text Show Details
Wyeth Inc.
Patent: US2499352 , 1948 ; Full Text Show Details
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Rontondaro
Journal of the Association of Official Agricultural Chemists, 1957 , vol. 40, p. 824,827 Full Text Show Details
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Troponwerke
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Schrecker
Journal of Organic Chemistry, 1957 , vol. 22, p. 33 Full Text View citing articles Show Details
Niinobe
Yakugaku Zasshi, 1949 , vol. 69, p. 37 Chem.Abstr., 1949 , p. 9374
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Kanao
Yakugaku Zasshi, 1930 , vol. 50, p. 338,343;dtsch.Ref.S.43,46 Chem. Zentralbl., 1930 , vol. 101, # II p. 1695 Full Text Show Details
Imp. Chem. Ind.
Patent: DE750234 , 1938 ; DRP/DRBP Org.Chem. Full Text Show Details
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Bulletin de la Societe Chimique de France, 1951 , p. 94,95 Full Text Show Details
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Journal of Labelled Compounds, 1972 , vol. 8, p. 13,14, 19 Full Text Show Details
Kudrjasova; Chromov-Borisov
Journal of Organic Chemistry USSR (English Translation), 1967 , vol. 3, p. 1076 Zhurnal Organicheskoi Khimii, 1967 , vol. 3, p. 1117 Full Text Show Details
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Acta Chimica Academiae Scientiarum Hungaricae, 1967 , vol. 53, p. 279 Full Text Show Details
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Zhurnal Organicheskoi Khimii, 1967 , vol. 3, p. 1513,1470 Full Text Show Details
Lachman
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Kum-Tatt
Journal of Pharmacy and Pharmacology, 1960 , vol. 12, p. 666 Full Text Show Details
14 of 317
Comment (Pharmacological Data)
Bioactivities present
Reference
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Milne et al.
Analytical Chemistry, 1971 , vol. 43, p. 1815,1817 Full Text Show Details
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Journal of Pharmacy and Pharmacology, 1968 , vol. 20, p. 81,85 Full Text Show Details
Reisch; Alfes; Moellmann
Die Pharmazie, 1968 , vol. 23, # 5 p. 245 - 246 Title/Abstract Full Text View citing articles Show Details
Kracmar; Kracmarova
Cesko-Slovenska Farmacie, 1966 , vol. 15, p. 16,18 Full Text Show Details
Brannon; Hayden
Journal of the Association of Official Agricultural Chemists, 1964 , vol. 47, p. 918,927 Full Text Show Details
Bose; Raychaudhuri
Journal of the Indian Chemical Society, 1961 , vol. 38, p. 217,219 Full Text Show Details
Hoek et al.
Recueil des Travaux Chimiques des Pays-Bas, 1966 , vol. 85, p. 1039,1043 Full Text Show Details
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Pharmaceutica Acta Helvetiae, 1975 , vol. 50, p. 360,364 Full Text Show Details
Abignente; Biniecka Picazio
Acta Poloniae Pharmaceutica - Drug Research, 1977 , vol. 34, # 3 p. 241 - 244 Title/Abstract Full Text View citing articles Show Details
Leader
Analytical Chemistry, 1973 , vol. 45, p. 1700,1706 Full Text Show Details
Sciortino
Bollettino Chimico Farmaceutico, 1966 , vol. 105, p. 223,224 Full Text Show Details
Brandstaetter-Kuhnert et al.
Scientia Pharmaceutica, 1960 , vol. 28, # 1 p. 7,8-15 Chem.Abstr., 1960 , # 17802 Full Text Show Details
Domelsmith; Munchausen; Houk
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Doyle; Proctor
Journal - Association of Official Analytical Chemists, 1972 , vol. 55, p. 328,329 Full Text Show Details
Budini; Marinangeli
Z. Naturforsch., B: Anorg. Chem., Org. Chem., Biochem., Biophys.,, 1970 , vol. 25, p. 505,507 Full Text Show Details
Luca et al.
Revista de Chimie (Bucharest, Romania), 1979 , vol. 30, p. 72 Full Text Show Details
Seiler; Wiechmann
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1964 , vol. 337, p. 229,231, 238 Full Text Show Details
15 of 317
16 of 317
Comment (Pharmacological Data)
Bioactivities present
Reference
Rossi et al.
Helvetica Chimica Acta, 1960 , vol. 43, p. 1046,1052 Full Text Show Details
Furman
Journal - Association of Official Analytical Chemists, 1968 , vol. 51, p. 1111,1115 Full Text Show Details
Garrett, Chembarkar
Journal of Pharmaceutical Sciences, 1968 , vol. 57, p. 1401,1402 Full Text Show Details
Hunneman
Chemiker-Zeitung, 1974 , vol. 98, p. 28,32 Full Text Show Details
Miles; Schenk
Analytical Chemistry, 1973 , vol. 45, p. 130,132 Full Text Show Details
Chatten; Harris
Analytical Chemistry, 1962 , vol. 34, p. 1495,1499 Full Text Show Details
De Silva; Strojny
Analytical Chemistry, 1975 , vol. 47, p. 714,716, 718 Full Text View citing articles Show Details
Mousseron et al.
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1960 , vol. 250, p. 786 Full Text Show Details
Freiter; Abdallah; Strycker
Journal of medicinal chemistry, 1973 , vol. 16, # 5 p. 510 - 512 Title/Abstract Full Text View citing articles Show Details
Schreiber et al.
Journal of the Chemical Society [Section] B: Physical Organic, 1971 , p. 2154 Full Text View citing articles Show Details
Sinsheimer; Keuhnellan
Journal of Pharmaceutical Sciences, 1966 , vol. 55, p. 1240,1241 Full Text Show Details
Duvall; Koshy; Pyles
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Lindenbaum et al.
Journal of the Chemical Society, Chemical Communications, 1977 , p. 268 Full Text View citing articles Show Details
Lanyi et al.
Chemische Berichte, 1967 , vol. 100, # 9 p. 3045 Full Text Show Details
Humbert; Laurent
Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1971 , vol. 272, p. 1165 Full Text Show Details
Landor et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1974 , p. 1294,1299 Full Text Show Details
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Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1974 , p. 1902 Full Text Show Details
Potapow; Terent'ew
J. Gen. Chem. USSR (Engl. Transl.), 1961 , vol. 31, p. 1003,927 Chem.Abstr., 1961 , # 23389 Full Text Show Details
Griffin; Banker
Journal of Pharmaceutical Sciences, 1967 , vol. 56, p. 1098,1099 Full Text Show Details
Sung; Parker
Zeitschrift fuer Naturforschung, C: Journal of Biosciences, 1974 , vol. 29, p. 122,124 Full Text Show Details
Comment (Pharmacological Data)
Bioactivities present
17 of 317
Reference
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Kliger et al.
Neftekhimiya, 1977 , vol. 17, p. 602,605 Chem.Abstr., 1978 , vol. 88, # 22040 Full Text Show Details
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Acta Pharmaceutica Suecica, 1977 , vol. 14, p. 335,340 Full Text Show Details
Brandenberger
Pharmaceutica Acta Helvetiae, 1970 , vol. 45, p. 394,406 Full Text Show Details
Prajsnar
Zeszyty Naukowe Politechniki Slaskiej, Chemia, 1963 , vol. 20, p. 1,72 Full Text Show Details
Cooper; Macnicol
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1978 , p. 760 Full Text Show Details
Ehrsson; Broetel
Acta Pharmaceutica Suecica, 1971 , vol. 8, p. 591,596 Full Text Show Details
Beckett; Moffat
The Journal of pharmacy and pharmacology, 1969 , vol. 21, p. Suppl:144S+ Title/Abstract Full Text View citing articles Show Details
Christol et al.
Bulletin de la Societe Chimique de France, 1961 , p. 2317 Full Text Show Details
Nace; King
Journal of Medicinal and Pharmaceutical Chemistry, 1962 , vol. 5, p. 1316,1321 Full Text Show Details
Riley; Brier
Journal of medicinal chemistry, 1972 , vol. 15, # 11 p. 1187 - 1188 Title/Abstract Full Text Show Details
Mihailova; Testa
European Journal of Medicinal Chemistry, 1978 , vol. 13, # 1 p. 49 - 52 Title/Abstract Full Text View citing articles Show Details
Arsenault et al.
Analytical Chemistry, 1971 , vol. 43, p. 1720 Full Text View citing articles Show Details
Serck-Hanssen
Archives of Mass Spectral Data, 1971 , vol. 2, p. 760 Full Text Show Details
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Journal of Medicinal Chemistry, 1972 , vol. 15, p. 17,20 Full Text Show Details
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Blang; Huang
Journal of Pharmaceutical Sciences, 1973 , vol. 62, p. 652 Full Text View citing articles Show Details
Blang; Huang
Journal of Pharmaceutical Sciences, 1972 , vol. 61, p. 1770,1772, 1774 Full Text View citing articles Show Details
Cartoni et al.
Bollettino Chimico Farmaceutico, 1976 , vol. 115, p. 347,350 Full Text Show Details
Comment (Pharmacological Data)
Bioactivities present
Reference
Kamei et al.
Chemical and Pharmaceutical Bulletin, 1973 , vol. 21, p. 1996,2000 Full Text Show Details
Boulassier; Chatelus
Annales de Chimie (Cachan, France), 1972 , vol. 7, # 14 p. 169,172,173 Full Text Show Details
Bergin; Carlstroem
Acta Crystallographica, Section B: Structural Crystallography and Crystal Chemistry, 1971 , vol. 27, p. 2146,2151 Full Text Show Details
Fontani; Morandini
The Journal of pharmacy and pharmacology, 1970 , vol. 22, # 6 p. 411 - 413 Title/Abstract Full Text View citing articles Show Details
Donike
Journal of chromatography, 1973 , vol. 78, # 2 p. 273 - 279 Title/Abstract Full Text View citing articles Show Details
Cervinka et al.
Zeitschrift fuer Chemie (Stuttgart, Germany), 1968 , vol. 8, p. 24 Full Text Show Details
Thomis; Kotionis
Analytica Chimica Acta, 1956 , vol. 14, p. 457
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ALLEVA
Journal of medicinal chemistry, 1963 , vol. 6, p. 621 - 624 Title/Abstract Full Text View citing articles Show Details
Zapior; Czapkiewicz
Roczniki Chemii, 1962 , vol. 36, p. 1863,1866,1867 Chem.Abstr., vol. 58, # 11986 Full Text Show Details
Warren et al.
Journal - Association of Official Analytical Chemists, 1971 , vol. 54, p. 1179,1181,1186,1188 Full Text View citing articles Show Details
Ruckpaul et al.
Croatica Chemica Acta, 1977 , vol. 49, p. 339,343 Full Text Show Details
Rein et al.
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Journal of Pharmacy and Pharmacology, 1967 , vol. 19, p. 273,291 Full Text Show Details
Thies; Ermer
Naturwissenschaften, 1962 , vol. 49, p. 37 Full Text View citing articles Show Details
Bloor; Morrinson
Journal of Pharmacy and Pharmacology, 1972 , vol. 24, p. 927,928,931,932 Full Text View citing articles Show Details
Modin; Johansson
Acta Pharmaceutica Suecica, 1971 , vol. 8, p. 561,565 Full Text Show Details Smythies et al.
Experientia, 1971 , vol. 27, p. 62,63 Full Text Show Details
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Journal of Medicinal Chemistry, 1971 , vol. 14, p. 717,718 Full Text Show Details
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Tetrahedron Letters, 1976 , p. 1001 Full Text View citing articles Show Details
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Pharmazie, 1976 , vol. 31, p. 452,453 Full Text Show Details
18 of 317
Comment (Pharmacological Data)
Bioactivities present
Reference
Kumbar
Journal of Medicinal Chemistry, 1976 , vol. 19, p. 1232,1234 Full Text Show Details
Lambert et al.
Spectroscopy Letters, 1975 , vol. 8, p. 509,511 Full Text Show Details
Klosa
Journal fuer Praktische Chemie (Leipzig), 1967 , vol. 35, p. 319 Full Text Show Details
Milstein
Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 339 Full Text Show Details
Burger; Siuda
Journal of medicinal chemistry, 1969 , vol. 12, # 2 p. 317 - 320 Title/Abstract Full Text Show Details
Kotera et al.
Tetrahedron Letters, 1967 , p. 841 Full Text Show Details
Soc. Chim. Org. Biol.
Patent: FRM79 , 1960 ; Chem.Abstr., 1963 , vol. 58, # 10302g Full Text Show Details
Donike; Iffland; Jaenicke
Arzneimittel-Forschung, 1974 , vol. 24, # 4 p. 556 - 560 Title/Abstract Full Text View citing articles Show Details
Bruderer et al.
Helvetica Chimica Acta, 1967 , vol. 50, p. 1917 Full Text Show Details
Dumpis, M. A.; Kudryashova, N. I.; Veresova, M. A.
Journal of Organic Chemistry USSR (English Translation), 1989 , vol. 25, # 7.2 p. 1332 - 1337 Zhurnal Organicheskoi Khimii, 1989 , vol. 25, # 7 p. 1477 - 1482 Title/Abstract Full Text Show Details
Harsy, Stephen G.
Tetrahedron, 1990 , vol. 46, # 21 p. 7403 - 7412 Title/Abstract Full Text View citing articles Show Details
Kabalka, George W.; Laila Guindi; Varma, Rajender S.
Tetrahedron, 1990 , vol. 46, # 21 p. 7443 - 7457 Title/Abstract Full Text View citing articles Show Details
Kadushkin; Golovko; Granik; Glushkov; Parimbetova; Parshin; Mashkovskii
Pharmaceutical Chemistry Journal, 1990 , vol. 23, # 10 p. 803 - 806 Title/Abstract Full Text View citing articles Show Details
Glennon, Richard A.; Smith, J. Doyle; Ismaiel, Abd M.; El-Ashmawy, Mahmoud; Battaglia, George; Fisher, James B.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1094 - 1098 Title/Abstract Full Text View citing articles Show Details
Vogt Chr.; Jira Th.; Beyrich Th.
Pharmazie, 1990 , vol. 45, # 9 p. 691 - 691 Title/Abstract Full Text View citing articles Show Details
Gee, Antony; Langstroem, Bengt
Acta Chemica Scandinavica, 1991 , vol. 45, # 4 p. 431 - 435 Title/Abstract Full Text Show Details
Johnson; Frescas; Oberlender; Nichols
Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1662 - 1668 Title/Abstract Full Text View citing articles Show Details
Solomina, L. P.; Sarkisyan, A. B.; Pirdzhanov, L. Sh.; Arzanunts, E. M.; Sarkisyan, I. S.; et al.
Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 4 p. 272 - 275 Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 4 p. 40 - 42 Title/Abstract Full Text View citing articles Show Details
Inaba, Takashi; Fujita, Makoto; Ogura, Katsuyuki
Journal of Organic Chemistry, 1991 , vol. 56, # 3 p. 1274 - 1279 Title/Abstract Full Text View citing articles Show Details
Mori; Ishiyama; Akita; Suzuki; Mitsuoka; Oishi
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 12 p. 3449 - 3451 Title/Abstract Full Text View citing articles Show Details
19 of 317
Comment (Pharmacological Data)
Bioactivities present
Reference
Ershov, L. V.; Granik, V. G.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1985 , vol. 21, # 5 p. 544 - 547 Khimiya Geterotsiklicheskikh Soedinenii, 1985 , vol. 21, # 5 p. 646 - 649 Title/Abstract Full Text View citing articles Show Details
Valenta, Vladimir; Vlkova, Marie; Holubek, Jiri; Metysova, Jirina; Protiva, Miroslav
Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 7 p. 1979 - 1994 Title/Abstract Full Text Show Details
Jilek, Jiri; Urban, Jiri; Taufmann, Petr; Holubek, Jiri; Dlabac, Antonin; et al.
Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 7 p. 1995 - 2008 Title/Abstract Full Text Show Details
Machkova, Zuzana; Zavada, Jiri
Collection of Czechoslovak Chemical Communications, 1981 , vol. 46, # 4 p. 833 - 849 Title/Abstract Full Text Show Details
Sycheva, T. V.; Yakhontov, L. N.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1985 , vol. 21, # 1 p. 68 - 72 Khimiya Geterotsiklicheskikh Soedinenii, 1985 , vol. 21, # 1 p. 84 - 88 Title/Abstract Full Text View citing articles Show Details
Vlasova, M. I.; Kogan, N. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , p. 43 - 48 Khimiya Geterotsiklicheskikh Soedinenii, 1983 , vol. 19, # 1 p. 49 - 54 Title/Abstract Full Text View citing articles Show Details
Pirkle, William H.; Simmons, Kirk A.
Journal of Organic Chemistry, 1981 , vol. 46, # 16 p. 3239 - 3246 Title/Abstract Full Text View citing articles Show Details
Rangnekar, V. M.; Lokhande, S. R.; Bhamaria, R. P.; Khadse, B. G.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 10 p. 1070 - 1071 Title/Abstract Full Text Show Details
Agarwal, Shiv K.; Kumar, Yatendra; Saxena, Anil K.; Jain, Padam C.; Anand, Nitya
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 5 p. 435 - 439 Title/Abstract Full Text Show Details
Nagarajan; Shenoy; Talwalker
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1989 , vol. 28, # 4 p. 326 - 332 Title/Abstract Full Text View citing articles Show Details
Ali, Abdel Rahman el Nasser Ossman
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 8 p. 762 - 765 Title/Abstract Full Text Show Details
Zappey, Herman; Fokkens, Roel H.; Ingemann, Steen; Nibbering, Nico M. M.; Florencio, Helena
Organic Mass Spectrometry, 1991 , vol. 26, # 6 p. 587 - 594 Title/Abstract Full Text Show Details
Kadushkin, A. V.; Nesterova, I. N.; Golovko, T. V.; Nikolaeva, I. S.; Pushkina, T. V.; et al.
Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 12 p. 875 - 881 Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 12 p. 18 - 22 Title/Abstract Full Text View citing articles Show Details
Glennon, Richard A.; Raghupathi, Reva; Bartyzel, Piotr; Teitler, Milt; Leonhardt, Sigrun
Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 734 - 740 Title/Abstract Full Text View citing articles Show Details
Wessling, Michael; Schaefer, Hans J.
Chemische Berichte, 1991 , vol. 124, # 10 p. 2303 - 2306 Title/Abstract Full Text Show Details
Hornback, Joseph M.; Murugaverl, Balasingam
Tetrahedron Letters, 1989 , vol. 30, # 43 p. 5853 - 5856 Title/Abstract Full Text View citing articles Show Details
Vejdelek, Zdenek; Nemec, Jiri; Protiva, Miroslav
Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 7 p. 1487 - 1493 Title/Abstract Full Text Show Details
Leclerc, Gerard; Decker, Nicole; Schwartz, Jean
Journal of Medicinal Chemistry, 1982 , vol. 25, # 6 p. 709 - 714
Title/Abstract Full Text View citing articles Show Details
Hathaway; Nichols; Yim
Journal of Medicinal Chemistry, 1982 , vol. 25, # 5 p. 535 - 538 Title/Abstract Full Text View citing articles Show Details
Grunewald, Gary L.; Monn, James A.; Rafferty, Michael F,; Borchardt, Ronald T.; Krass, Polina
Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1248 - 1250 Title/Abstract Full Text View citing articles Show Details
20 of 317
Show next 20
21 of 317
Comment (Pharmacological Data)
Bioactivities present
Reference
Kwiatkowski; Jeganathan; Tobin; Watt
Synthesis, 1989 , # 12 p. 946 - 949 Title/Abstract Full Text View citing articles Show Details
Kivokurtseva, L. N.
Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 11 p. 797 - 798 Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 11 p. 78 - 80 Title/Abstract Full Text View citing articles Show Details
Taube, D. O.; Lukinskaya, E. P.; Passet, B. V.
Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 1 p. 50 - 54 Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 1 p. 62 - 67 Title/Abstract Full Text View citing articles Show Details
Saxena; Bhalla; Verma; Shanker
Journal of the Indian Chemical Society, 1991 , vol. 68, # 3 p. 142 - 143 Title/Abstract Full Text View citing articles Show Details
Vecchietti; Clarke; Colle; Dondio; Giardina; Petrone; Sbacchi
Journal of Medicinal Chemistry, 1992 , vol. 35, # 16 p. 2970 - 2978 Title/Abstract Full Text View citing articles Show Details
Harsche; Oelschlaeger; Engel
Archiv der Pharmazie, 1992 , vol. 325, # 9 p. 593 - 595 Title/Abstract Full Text View citing articles Show Details
Oelschlager; Harsche; Engel
Archiv der Pharmazie, 1991 , vol. 324, # 9 p. 543 - 546 Title/Abstract Full Text View citing articles Show Details
Dozorova, E. N.; Kadushkin, A. V.; Bogdanova, G. A.; Solov'eva, N. P.; Granik, V. G.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1991 , vol. 27, # 6 p. 590 - 594 Khimiya Geterotsiklicheskikh Soedinenii, 1991 , vol. 27, # 6 p. 754 - 758 Title/Abstract Full Text View citing articles Show Details
Shahidi, Fereidoon
Canadian Journal of Chemistry, 1987 , vol. 65, p. 1924 - 1926 Title/Abstract Full Text Show Details
Toda, Fumio; Mori, Koji; Okada, Jyoji; Node, Manabu; Itoh, Akichika; et al.
Chemistry Letters, 1988 , p. 131 - 134 Title/Abstract Full Text Show Details
Amlaiky; Leclerc; Decker; Schwartz
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 4 p. 341 - 346 Title/Abstract Full Text View citing articles Show Details
Hess; Ziebig
Pharmazie, 1981 , vol. 36, # 4 p. 253 - 256 Title/Abstract Full Text View citing articles Show Details
Hamdy; Fahim
Pharmazie, 1982 , vol. 37, # 3 p. 206 - 208 Title/Abstract Full Text View citing articles Show Details
Hess, Ulrich; Dunkel, Silke
Zeitschrift fuer Chemie (Stuttgart, Germany), 1988 , vol. 28, # 10 p. 372 - 373 Title/Abstract Full Text Show Details
Hess; Marleneziebig
Pharmazie, 1982 , vol. 37, # 2 p. 107 - 111 Title/Abstract Full Text View citing articles Show Details
Glennon; Liebowitz; Anderson III
Journal of Medicinal Chemistry, 1980 , vol. 23, # 3 p. 294 - 299 Title/Abstract Full Text View citing articles Show Details
Clark; Wells; Sansom; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 6 p. 779 - 782 Title/Abstract Full Text View citing articles Show Details
Andrews; Craik; Martin
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1648 - 1657 Title/Abstract Full Text View citing articles Show Details
El-Torki, Farid M.; Jacobus John
Journal of Organic Chemistry, 1985 , vol. 50, # 8 p. 1314 - 1316 Title/Abstract Full Text View citing articles Show Details
Harris; Middlemiss; Mills; Gower; Tyers
Journal of Medicinal Chemistry, 1983 , vol. 26, # 1 p. 55 - 60 Title/Abstract Full Text View citing articles Show Details
Hide facts Comment (Pharmacological Data)
Bioactivities present
Reference
Sarkisyan, A. B.; Solomina, L. P.; Pirdzhanov, L. Sh.; Markaryan, E. A.; Arzanunt, E. M.; et al.
Pharmaceutical Chemistry Journal, 1985 , vol. 19, # 4 p. 256 - 258 Khimiko-Farmatsevticheskii Zhurnal, 1985 , vol. 19, # 4 p. 423 - 425 Title/Abstract Full Text View citing articles Show Details
Kudryashova, N. I.; Dumpis, M. A.; Sapronov, N. S.; Shabanov, P. D.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 9 p. 669 - 672 Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 9 p. 1067 - 1070 Title/Abstract Full Text View citing articles Show Details
Balayan, R. S.; Akopyan, M. G.; Vartanyan, R. M.; Kaltrikyan, A. A.; Avakyan, O. M.; et al.
Pharmaceutical Chemistry Journal, 1985 , vol. 19, # 8 p. 558 - 562 Khimiko-Farmatsevticheskii Zhurnal, 1985 , vol. 19, # 8 p. 956 - 960 Title/Abstract Full Text View citing articles Show Details
Gevorkyan, K. A.; Papayan, G. L.; Shirinyan, E. A.; Atayan, T. K.; Vorskanyan, A. S.
Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 7 p. 484 - 487 Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 7 p. 806 - 808 Title/Abstract Full Text View citing articles Show Details
Modnikova, G. A.; Titkova, R. M.; Glushkov, R. G.; Sokolova, A. S.; Silin, V. A.; Chernov, V. A.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 2 p. 135 - 141 Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 2 p. 185 - 191 Title/Abstract Full Text View citing articles Show Details
Filitis, L. N.; Akalaeva, T. V.; Amel'kin, O. Yu.; Bokanov, A. I.; Ivanov, P. Yu.; Shvedov, V. I.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 10 p. 780 - 785 Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 10 p. 1217 - 1222 Title/Abstract Full Text View citing articles Show Details
Piotrovskii, L. B.; Dumpis, M. A.; Shabanov, P. D.
Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 7 p. 460 - 463 Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 7 p. 799 - 802 Title/Abstract Full Text View citing articles Show Details
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Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 7 p. 483 - 488 Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 7 p. 830 - 835 Title/Abstract Full Text View citing articles Show Details
Rangnekar, V. M.; Bhamaria, R. P.; Khadse, B. G.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 342 - 344 Title/Abstract Full Text Show Details
Das, Michael; Chaudhuri, Subhankar; Ray, Manotosh R.; Chakravorti, S. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 1072 - 1078 Title/Abstract Full Text Show Details
Caldirola, PM; Goot, H van der; Timmerman, H
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 571 - 579 Title/Abstract Full Text View citing articles Show Details
Meincke; Kottke; Beyrich
Pharmazie, 1992 , vol. 47, # 9 p. 697 - 699 Title/Abstract Full Text View citing articles Show Details
Frison, G.; Castagna, F.; Brusini, G.; Tedeschi, L.; Seraglia, R.; Traldi, P.
Organic Mass Spectrometry, 1992 , vol. 27, # 11 p. 1284 - 1288 Title/Abstract Full Text Show Details
Meincke; Kottke; Beyrich
Pharmazie, 1992 , vol. 47, # 10 p. 780 - 783 Title/Abstract Full Text View citing articles Show Details
Shivanyuk; Losev; Vargashkin; Bobkov; Lozinskii
Pharmaceutical Chemistry Journal, 1992 , vol. 26, # 5 p. 430 - 432 Title/Abstract Full Text View citing articles Show Details
Border, Corinne L.; Craik, David J.; Shehan, B. Philip
Magnetic Resonance in Chemistry, 1993 , vol. 31, # 3 p. 222 - 230 Title/Abstract Full Text Show Details
Castro, C. E.; Jamin, Mary; Yokoyama, W.; Wade, Ruth
Journal of the American Chemical Society, 1986 , vol. 108, # 14 p. 4179 - 4187 Title/Abstract Full Text View citing articles Show Details
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Todd; Stafford Jr.; Kelley; Syka; Cooks; Louris
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22 of 317
Comment (Pharmacological Data)
Bioactivities present
Reference
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Kuliev, A. B.; Abdullaeva, M. I.; Akhadov, N. O.
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Glennon, Richard A.; McKenney, J. D.; Lyon, Robert A.; Titeler, Milt
Journal of Medicinal Chemistry, 1986 , vol. 29, # 2 p. 194 - 199 Title/Abstract Full Text View citing articles Show Details
Caroon, Joan M.; Clark, Robin D.; Kluge, Arthur F.; Lee, Chi-Ho; Strosberg, Arthur M.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1426 - 1433 Title/Abstract Full Text View citing articles Show Details
Hamada, Akihiko; Chang, Yu An; Uretsky, Norman; Miller, Duane D.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 675 - 680 Title/Abstract Full Text View citing articles Show Details
Butler; Nordin; L'Italien; Zweisler; Poschel; Marriott
Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 684 - 691
Title/Abstract Full Text View citing articles Show Details
Rafferty, Michael F.; Wilson, David S.; Monn, James A.; Krass, Polina; Borchardt, Ronald T.; Grunewald, Gary L.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1198 - 1204 Title/Abstract Full Text View citing articles Show Details
Rafferty; Borchardt; Grunewald
Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1204 - 1208 Title/Abstract Full Text View citing articles Show Details
Blume
Arzneimittel-Forschung/Drug Research, 1981 , vol. 31, # 6 p. 994 - 997 Title/Abstract Full Text View citing articles Show Details
Jacquot; Rapin
Arzneimittel-Forschung/Drug Research, 1980 , vol. 30, # 5 p. 776 - 779 Title/Abstract Full Text View citing articles Show Details
Ruecker; Neugebauer
Archiv der Pharmazie, 1986 , vol. 319, # 4 p. 317 - 324 Title/Abstract Full Text View citing articles Show Details
Bell, Harold M.; Bowles, Deborah B.; Senese, Fred
Organic Magnetic Resonance, 1981 , vol. 16, # 4 p. 285 - 289 Title/Abstract Full Text Show Details
Schonenberger; Brossi
Helvetica Chimica Acta, 1986 , vol. 69, # 6 p. 1486 - 1497 Title/Abstract Full Text View citing articles Show Details
Leclerc; Decker; Schwartz
Arzneimittel-Forschung/Drug Research, 1985 , vol. 35, # 9 p. 1357 - 1367 Title/Abstract Full Text View citing articles Show Details
Pittner
Arzneimittel-Forschung/Drug Research, 1983 , vol. 33, # 1 A p. 13 - 25 Title/Abstract Full Text View citing articles Show Details
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Arzneimittel-Forschung/Drug Research, 1983 , vol. 33, # 5 p. 726 - 730 Title/Abstract Full Text View citing articles Show Details
Blume
Arzneimittel-Forschung/Drug Research, 1981 , vol. 31, # 5 p. 805 - 809 Title/Abstract Full Text View citing articles Show Details
Javaid; Davis
Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 7 p. 813 - 815 Title/Abstract Full Text View citing articles Show Details
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Journal of Medicinal Chemistry, 1988 , vol. 31, # 8 p. 1558 - 1566 Title/Abstract Full Text View citing articles Show Details
Varma, Rajender S.; Kabalka, George W.
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23 of 317
Comment (Pharmacological Data)
Bioactivities present
Reference
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Journal of Medicinal Chemistry, 1983 , vol. 26, # 5 p. 649 - 657 Title/Abstract Full Text View citing articles Show Details
Glennon; Young; Benington; Morin
Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1163 - 1168 Title/Abstract Full Text View citing articles Show Details
Baldwin, Jack E.; Adlington, Robert M.; Newington, Ian M.
Journal of the Chemical Society, Chemical Communications, 1986 , # 2 p. 176 - 178 Title/Abstract Full Text View citing articles Show Details
Little; Rees
Journal of Pharmacy and Pharmacology, 1980 , vol. 32, # 11 p. 751 - 756 Title/Abstract Full Text View citing articles Show Details
Wermuth; Schlewer; Bourguignon; Maghioros; Bouchet; Moire; Kan; Worms; Biziere
Journal of Medicinal Chemistry, 1989 , vol. 32, # 3 p. 528 - 537 Title/Abstract Full Text View citing articles Show Details
Depin; Betbeder-Matibet; Bonhomme; Muller; Berthelon
Arzneimittel-Forschung/Drug Research, 1985 , vol. 35, # 11 p. 1655 - 1662 Title/Abstract Full Text View citing articles Show Details
Testa; Salvesen
Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 5 p. 497 - 501 Title/Abstract Full Text View citing articles Show Details
Tsai, Ruey-Shiuan; Fan, Weizheng; El Tayar, Nabil; Carrupt, Pierre-Alain; Testa, Bernard; Kier, Lemont B.
Journal of the American Chemical Society, 1993 , vol. 115, # 21 p. 9632 - 9639 Title/Abstract Full Text View citing articles Show Details
Caldirola, P.; Zandberg, P.; Mannhold, R.; Timmerman, H.
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 7-8 p. 555 - 568 Title/Abstract Full Text View citing articles Show Details
Nakazawa, Hidetsugu; Kumagai, Hidehiko; Yamada, Hideaki
Agricultural and Biological Chemistry, 1985 , vol. 49, # 1 p. 159 - 166 Title/Abstract Full Text Show Details
Comai; Sullivan
Journal of Pharmaceutical Sciences, 1982 , vol. 71, # 4 p. 418 - 421 Title/Abstract Full Text View citing articles Show Details
Borgna; Vicarini; Carmellino; Pagani
Farmaco, Edizione Scientifica, 1983 , vol. 38, # 10 p. 801 - 810 Title/Abstract Full Text View citing articles Show Details
Tajana; Pennini; Nardi
Farmaco, Edizione Scientifica, 1980 , vol. 35, # 3 p. 181 - 190
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Rucker; Neugebauer; Heiden
Arzneimittel-Forschung/Drug Research, 1988 , vol. 38, # 4 p. 497 - 501 Title/Abstract Full Text View citing articles Show Details
Nakazawa, Hidetsugu; Kumagai, Hidehiko; Yamada, Hideaki
Agricultural and Biological Chemistry, 1981 , vol. 45, # 11 p. 2543 - 2552 Title/Abstract Full Text Show Details
Saxena; Verma; Shanker
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Kuliev; Kurbanov; Mamedov
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Hanquet, Gilles; Lusinchi, Xavier
Tetrahedron, 1994 , vol. 50, # 42 p. 12185 - 12200 Title/Abstract Full Text View citing articles Show Details
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Donner
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24 of 317
Comment (Pharmacological Data)
Bioactivities present
Reference
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Fitzgerald; Reid
Journal of Pharmacy and Pharmacology, 1994 , vol. 46, # 10 p. 826 - 832 Title/Abstract Full Text View citing articles Show Details
Buzas; Champagnac; Dehnel; Lavielle; Pommier
Journal of Medicinal Chemistry, 1980 , vol. 23, # 2 p. 149 - 153 Title/Abstract Full Text View citing articles Show Details
Neugebauer
Pharmazie, 1995 , vol. 50, # 3 p. 201 - 206 Title/Abstract Full Text View citing articles Show Details
Seres, J.; Daroczi-Csuka, K.; Gall-Istok, K.; Simon, K.; Szilagyi, I.
Journal of Chemical Research, Miniprint, 1995 , # 1 p. 244 - 273 Title/Abstract Full Text Show Details
Schultz, Arthur G.; Kirincich, Steven J.; Rahm, Rainer
Tetrahedron Letters, 1995 , vol. 36, # 26 p. 4551 - 4554 Title/Abstract Full Text View citing articles Show Details
Acs, Maria; Kozma, David; Fogassy, Elemer
ACH - Models in Chemistry, 1995 , vol. 132, # 3 p. 475 - 478 Title/Abstract Full Text Show Details
Bell; Cantrell; Hogberg; Jaskunas; Johansson; Jordan; Kinnick; Lind; Morin Jr.; Noreen; Oberg; Palkowitz; Parrish; Pranc; Sahlberg; Ternansky; Vasileff; Vrang; West; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4929 - 4936 Title/Abstract Full Text View citing articles Show Details
Biagi; Giorgi; Livi; Scartoni; Breschi; Martini; Scatizzi
Farmaco, 1995 , vol. 50, # 10 p. 659 - 667 Title/Abstract Full Text View citing articles Show Details
Isakovich, I. P.; Azimov, V. A.; Ryabova, S. Yu.; Alekseeva, L. M.; Parshin, V. P.; et al.
Pharmaceutical Chemistry Journal, 1995 , vol. 29, # 2 p. 100 - 105 Khimiko-Farmatsevticheskii Zhurnal, 1995 , vol. 29, # 2 p. 22 - 26 Title/Abstract Full Text Show Details
Micovic, Ivan V.; Ivanovic; Roglic, Goran M.; Kiricojevic, Vesna D.; Popovic, Jelena B.
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Grunewald, Gary L.; Dahanukar, Vilas H.; Ching, Piao; Criscione, Kevin R.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 18 p. 3539 - 3546 Title/Abstract Full Text View citing articles Show Details
Kaufman, Melvin S.; Hatzis, Alexander C.; Stuart, John G.
Journal of Mass Spectrometry, 1996 , vol. 31, # 8 p. 913 - 920 Title/Abstract Full Text View citing articles Show Details
Omelanczuk, Jan; Mikolajczyk, Marian
Tetrahedron Asymmetry, 1996 , vol. 7, # 9 p. 2687 - 2694 Title/Abstract Full Text View citing articles Show Details
Sun; Bernstein
Journal of the American Chemical Society, 1996 , vol. 118, # 21 p. 5086 - 5095 Title/Abstract Full Text View citing articles Show Details
Biagi; Giorgi; Livi; Manera; Scartoni; Lucacchini; Senatore
Farmaco, 1996 , vol. 51, # 8-9 p. 601 - 608 Title/Abstract Full Text View citing articles Show Details
Riddell, Frank G.; Rogerson, Martin
Journal of the Chemical Society. Perkin Transactions 2, 1997 , # 2 p. 249 - 255 Title/Abstract Full Text View citing articles Show Details
Unterhalt; Bause
Pharmazie, 1997 , vol. 52, # 11 p. 878 - 878 Title/Abstract Full Text View citing articles Show Details
Mazurov, Anatoly A.; Andronati, Sergei A.; Korotenko, Tamara I.; Sokolenko, Nikolai I.; Dyadenko, Alexei I.; Shapiro, Yury E.; Gorbatyuk, Vitalii Ya.; Voronina, Tatyana A.
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Sparatore; Novelli
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25 of 317
26 of 317
Comment (Pharmacological Data)
Bioactivities present
Reference
Nagasawa, Kazuo
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Parker, Matthew A.; Marona-Lewicka, Danuta; Kurrasch, Deborah; Shulgin, Alexander T.; Nichols, David E.
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Betti, Laura; Biagi, Giuliana; Giannaccini, Gino; Giorgi, Irene; Livi, Oreste; Lucacchini, Antonio; Manera, Clementina; Scartoni, Valerio
Journal of Medicinal Chemistry, 1998 , vol. 41, # 5 p. 668 - 673 Title/Abstract Full Text View citing articles Show Details
Thunhorst, Martin; Holzgrabe, Ulrike
Magnetic Resonance in Chemistry, 1998 , vol. 36, # 3 p. 211 - 216 Title/Abstract Full Text View citing articles Show Details
Estep, Kimberly G.; Neipp, Christopher E.; Stephens Stramiello, Linda M.; Adam, Mavis D.; Allen, Martin P.; Robinson, Shaughnessy; Roskamp, Eric J.
Journal of Organic Chemistry, 1998 , vol. 63, # 16 p. 5300 - 5301 Title/Abstract Full Text View citing articles Show Details
Pifl, Christian; Drobny, Helmut; Reither, Harald; Hornykiewicz, Oleh; Singer, Ernst A.
Molecular Pharmacology, 1995 , vol. 47, # 2 p. 368 - 373 Title/Abstract Full Text View citing articles Show Details
Kikura; Nakahara
Biological and Pharmaceutical Bulletin, 1995 , vol. 18, # 12 p. 1694 - 1699 Title/Abstract Full Text View citing articles Show Details
Wall, Stephen C.; Gu, Howard; Rudnick, Gary
Molecular Pharmacology, 1995 , vol. 47, # 3 p. 544 - 550 Title/Abstract Full Text View citing articles Show Details
Protais; Chagraoui; Arbaoui; Mocaer
European Journal of Pharmacology, 1994 , vol. 271, # 1 p. 167 - 177 Title/Abstract Full Text View citing articles Show Details
Seager
Journal of Pharmacy and Pharmacology, 1998 , vol. 50, # 4 p. 375 - 382 Title/Abstract Full Text View citing articles Show Details
Morozov; Klimova; Lavrova; Avdyunina; Pyatin; Troitskaya; Bykov
Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 1 p. 1 - 4 Title/Abstract Full Text View citing articles Show Details
Humphreys; Tanner
Human and Experimental Toxicology, 1994 , vol. 13, # 5 p. 311 - 312 Title/Abstract Full Text View citing articles Show Details
Cirimele; Kintz; Mangin
Archives of Toxicology, 1995 , vol. 70, # 1 p. 68 - 69 Title/Abstract Full Text View citing articles Show Details
Nakahara, Yuji; Kikura, Ruri
Archives of Toxicology, 1996 , vol. 70, # 12 p. 841 - 849 Title/Abstract Full Text View citing articles Show Details
Markaryan; Airapetyan; Mikaelyan; Asatryan; Noravyan
Pharmaceutical Chemistry Journal, 1997 , vol. 31, # 2 p. 71 - 73 Title/Abstract Full Text View citing articles Show Details
Gyenes, Ferenc; Bergmann, Kathryn E.; Welch, John T.
Journal of Organic Chemistry, 1998 , vol. 63, # 9 p. 2824 - 2828 Title/Abstract Full Text View citing articles Show Details
Avakyan; Vartanyan; Markaryan; Asatryan; Noravyan; Gevondyan
Pharmaceutical Chemistry Journal, 1997 , vol. 31, # 4 p. 178 - 181 Title/Abstract Full Text View citing articles Show Details
Nakahara; Takahashi; Kikura
Biological and Pharmaceutical Bulletin, 1995 , vol. 18, # 9 p. 1223 - 1227 Title/Abstract Full Text View citing articles Show Details
Sasaki; Shibata; Hashimoto; Iwasaki
Biological and Pharmaceutical Bulletin, 1995 , vol. 18, # 9 p. 1228 - 1233 Title/Abstract Full Text View citing articles Show Details
Maurel-Remy; Bervoets; Millan
European Journal of Pharmacology, 1995 , vol. 280, # 2 p. R9-R11 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
Bioactivities present
Reference
Banks; Gratton
European Journal of Pharmacology, 1995 , vol. 282, # 1-3 p. 157 - 167 Title/Abstract Full Text View citing articles Show Details
Schmidt; Sorensen; Kehne; Carr; Palfreyman
Life Sciences, 1995 , vol. 56, # 25 p. 2209 - 2222 Title/Abstract Full Text View citing articles Show Details
Chueh; Hsieh; Chen; Lin
Pharmacology, 1995 , vol. 51, # 4 p. 237 - 244 Title/Abstract Full Text View citing articles Show Details
Browman; Badiani; Robinson
Journal of Pharmacology and Experimental Therapeutics, 1998 , vol. 287, # 3 p. 1007 - 1014 Title/Abstract Full Text View citing articles Show Details
Pal, Siddhartha; Sen; Chaudhuri, A.K. Nag
Journal of Pharmacy and Pharmacology, 1999 , vol. 51, # 3 p. 313 - 318 Title/Abstract Full Text View citing articles Show Details
Tsai, Shiow-Chwen; Chiao, Yu-Chung; Lu, Chien-Chen; Doong, Ming-Luen; Chen, Yen-Hao; Shih, Hsi-Chang; Liaw, Charlie; Wang, Shyi-Wu; Wang, Paulus S.
British Journal of Pharmacology, 1996 , vol. 118, # 4 p. 984 - 988 Title/Abstract Full Text View citing articles Show Details
Borel; Abbott
Chemical Research in Toxicology, 1995 , vol. 8, # 6 p. 891 - 899 Title/Abstract Full Text View citing articles Show Details
Betti, Laura; Biagi, Giuliana; Giannaccini, Gino; Giorgi, Irene; Livi, Oreste; Lucacchini, Antonio; Manera, Clementina; Scartoni, Valerio
European Journal of Medicinal Chemistry, 1999 , vol. 34, # 10 p. 867 - 875 Title/Abstract Full Text View citing articles Show Details
Bach, Mimi V.; Coutts; Baker
Xenobiotica, 1999 , vol. 29, # 7 p. 719 - 732 Title/Abstract Full Text View citing articles Show Details
Bach; Coutts; Baker
Xenobiotica, 2000 , vol. 30, # 3 p. 297 - 306 Title/Abstract Full Text View citing articles Show Details
Biagi, Giuliana; Giorgi, Irene; Livi, Oreste; Manera, Clementina; Scartoni, Valerio; Betti, Laura; Giannaccini, Gino; Lucacchini, Antonio
Farmaco, 1999 , vol. 54, # 9 p. 615 - 623 Title/Abstract Full Text View citing articles Show Details
Hartung, Christian G.; Breindl, Claudia; Tillack, Annegret; Beller, Matthias
Tetrahedron, 2000 , vol. 56, # 29 p. 5157 - 5162 Title/Abstract Full Text View citing articles Show Details
Subramanyam
Tetrahedron Letters, 2000 , vol. 41, # 34 p. 6537 - 6540 Title/Abstract Full Text View citing articles Show Details
Eshleman; Neve; Janowsky
Journal of Pharmacology and Experimental Therapeutics, 1995 , vol. 274, # 1 p. 276 - 283 Title/Abstract Full Text View citing articles Show Details
Wang; Johnson
Journal of Pharmacology and Experimental Therapeutics, 1995 , vol. 275, # 2 p. 877 - 884 Title/Abstract Full Text View citing articles Show Details
Kinbara, Kazushi; Harada, Yoshiko; Saigo, Kazuhiko
Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 7 p. 1339 - 1347 Title/Abstract Full Text View citing articles Show Details
Haak, Edgar; Siebeneicher, Holger; Doye, Sven
Organic Letters, 2000 , vol. 2, # 13 p. 1935 - 1937 Title/Abstract Full Text View citing articles Show Details
Blasco-Gomez; Bosch-Reig; Campins-Falco; Molins-Legua; Herraez-Hernandez
Analytical Chemistry, 2000 , vol. 72, # 11 p. 2559 - 2565 Title/Abstract Full Text View citing articles Show Details
Avakyan; Vartanyan; Markaryan; Asatryan; Noravyan
Pharmaceutical Chemistry Journal, 1999 , vol. 33, # 10 p. 528 - 530 Title/Abstract Full Text View citing articles Show Details
Ferrarini, Pier Luigi; Mori, Claudio; Badawneh, Muwaffag; Calderone, Vincenzo; Greco, Rosamiria; Manera, Clementina; Martinelli, Adriano; Nieri, Paola; Saccomanni, Giuseppe
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 9 p. 815 - 826 Title/Abstract Full Text View citing articles Show Details
27 of 317
Comment (Pharmacological Data)
Bioactivities present
Reference
Yu, Han; Rothman, Richard B; Dersch, Christina M; Partilla, John S; Rice, Kenner C
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 12 p. 2689 - 2692 Title/Abstract Full Text View citing articles Show Details
Dowd; Herrick-Davis; Egan; DuPre; Smith; Teitler; Glennon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 3074 - 3084 Title/Abstract Full Text View citing articles Show Details
Zurita, Alejandra; Muru, Sergio; Molina, Victor
European Journal of Pharmacology, 1996 , vol. 299, # 1-3 p. 1 - 7 Title/Abstract Full Text View citing articles Show Details
Eblen, Frank; Loeschmann, Peter-Andreas; Wuellner, Ullrich; Turski, Lechoslaw; Klockgether, Thomas
European Journal of Pharmacology, 1996 , vol. 299, # 1-3 p. 9 - 16 Title/Abstract Full Text View citing articles Show Details
Sills, Terrence L.; Crawley, Jacqueline N.
European Journal of Pharmacology, 1996 , vol. 303, # 3 p. 177 - 181 Title/Abstract Full Text View citing articles Show Details
Maes, J. H. Roald; Van Rijn, Clementina M.; Vossen, Jo M. H.
European Journal of Pharmacology, 1996 , vol. 309, # 2 p. 131 - 140 Title/Abstract Full Text View citing articles Show Details
Bansal, Ekta; Srivastava; Kumar, Ashok
European Journal of Medicinal Chemistry, 2001 , vol. 36, # 1 p. 81 - 92 Title/Abstract Full Text View citing articles Show Details
Yoneda, Fumio; Moto, Toshiaki; Sakae, Masatoshi; Ohde, Hironori; Knoll, Berta; Miklya, Ildiko; Knoll, Joseph
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 5 p. 1197 - 1212 Title/Abstract Full Text View citing articles Show Details
Davis; Durden
Synthetic Communications, 2001 , vol. 31, # 4 p. 569 - 578
Title/Abstract Full Text View citing articles Show Details
Bahajaj; Vernon; Wilson
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 12 p. 1446 - 1451 Title/Abstract Full Text View citing articles Show Details
Olds, Marianne E.
European Journal of Pharmacology, 1996 , vol. 306, # 1-3 p. 23 - 32 Title/Abstract Full Text View citing articles Show Details
Segal, David S.; Kuczenski, Ronald
Journal of Pharmacology and Experimental Therapeutics, 1999 , vol. 291, # 1 p. 19 - 30 Title/Abstract Full Text View citing articles Show Details
Devoto, Paola; Flore, Giovanna; Ibba, Antonio; Fratta, Walter; Pani, Luca
Toxicology Letters, 2001 , vol. 121, # 3 p. 199 - 206 Title/Abstract Full Text View citing articles Show Details
Sekine, Hitoshi; Nagao, Shigeyuki; Nakahara, Yuji
Biological and Pharmaceutical Bulletin, 1996 , vol. 19, # 6 p. 845 - 851 Title/Abstract Full Text View citing articles Show Details
Clement; Behrens; Moller; Cashman
Chemical Research in Toxicology, 2000 , vol. 13, # 10 p. 1037 - 1045 Title/Abstract Full Text View citing articles Show Details
Lapeyre-Mestre; Damase-Michel; Adams; Michaud; Montastruc
European Journal of Clinical Pharmacology, 1997 , vol. 52, # 1 p. 37 - 39 Title/Abstract Full Text View citing articles Show Details
Dierickx, Paul J.; Scheers, Ellen M.
Journal of Applied Toxicology, 2002 , vol. 22, # 1 p. 61 - 65 Title/Abstract Full Text View citing articles Show Details
Chang; Pan; Lin
British Journal of Pharmacology, 2001 , vol. 132, # 7 p. 1524 - 1530 Title/Abstract Full Text View citing articles Show Details
Janin, Yves L.; Roulland, Emmanuel; Beurdeley-Thomas, Arnaud; Decaudin, Didier; Monneret, Claude; Poupon, MarieFrance
Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 4 p. 529 - 532 Title/Abstract Full Text View citing articles Show Details
Biagi, Giuliana; Giorgi, Irene; Livi, Oreste; Scartoni, Valerio; Betti, Laura; Giannaccini, Gino; Trincavelli, Maria Letizia
European Journal of Medicinal Chemistry, 2002 , vol. 37, # 7 p. 565 - 571 Title/Abstract Full Text View citing articles Show Details
28 of 317
Comment (Pharmacological Data)
Bioactivities present
Reference
Abraham, Michael H; Zhao, Yuan H; Le, Joelle; Hersey, Anne; Luscombe, Christopher N; Reynolds, Derek P; Beck, Gordon; Sherborne, Brad; Cooper, Ian
European journal of medicinal chemistry, 2002 , vol. 37, # 7 p. 595 - 605 Title/Abstract Full Text View citing articles Show Details
Gonzalez-Sabin, Javier; Gotor, Vicente; Rebolledo, Francisca
Tetrahedron Asymmetry, 2002 , vol. 13, # 12 p. 1315 - 1320 Title/Abstract Full Text View citing articles Show Details
Pallavicini, Marco; Bolchi, Cristiano; Fumagalli, Laura; Valoti, Ermanno; Villa, Luigi
Tetrahedron Asymmetry, 2002 , vol. 13, # 20 p. 2277 - 2282 Title/Abstract Full Text View citing articles Show Details
Viswanathan, Rajesh; Prabhakaran, Erode N.; Plotkin, Michael A.; Johnston, Jeffrey N.
Journal of the American Chemical Society, 2003 , vol. 125, # 1 p. 163 - 168 Title/Abstract Full Text View citing articles Show Details
Li, Yanjun; Izumi, Taeko
Journal of the Chinese Chemical Society (Taipei, Taiwan), 2002 , vol. 49, # 4 p. 505 - 508 Title/Abstract Full Text View citing articles Show Details
Hedou, Gael; Homberg, Judith; Martin, Sonsoles; Wirth, Katja; Feldon, Joram; Heidbreder, Christian A.
European Journal of Pharmacology, 2000 , vol. 390, # 1-2 p. 127 - 136 Title/Abstract Full Text View citing articles Show Details
Nagy, Peter I.; Alagona, Giuliano; Ghio, Caterina; Takacs-Novak, Krisztina
Journal of the American Chemical Society, 2003 , vol. 125, # 9 p. 2770 - 2785 Title/Abstract Full Text View citing articles Show Details
Hadzic, Pavle; Vukojevic, Nada
Carbohydrate Research, 2003 , vol. 338, # 11 p. 1243 - 1249 Title/Abstract Full Text View citing articles Show Details
Sun; Ginovart; Ko; Seeman; Kapur
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Comment (Pharmacological Data)
Bioactivities present
Reference
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Comment (Pharmacological Data)
Bioactivities present
Reference
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Comment (Pharmacological Data)
Bioactivities present
Reference
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Comment (Pharmacological Data)
Bioactivities present
Reference
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Comment (Pharmacological Data)
Bioactivities present
Reference
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Comment (Pharmacological Data)
Bioactivities present
Reference
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Comment (Pharmacological Data)
Bioactivities present
Reference
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Comment (Pharmacological Data)
Bioactivities present
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Comment
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Comment (Pharmacological Data)
Bioactivities present
Reference
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Comment (Pharmacological Data)
Bioactivities present
Reference
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Comment (Pharmacological Data)
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Reference
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Comment (Pharmacological Data)
Bioactivities present
Reference
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Comment (Pharmacological Data)
Bioactivities present
Reference
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Comment (Pharmacological Data)
Bioactivities present
Reference
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Al-Serori, Halh; Ferk, Franziska; Angerer, Verena; Mišík, Miroslav; Nersesyan, Armen; Setayesh, Tahereh; Auwärter, Volker; Haslinger, Elisabeth; Huber, Wolfgang; Knasmüller, Siegfried
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Beharry, Shruti; Gibbons, Simon
Forensic Science International, 2016 , vol. 267, p. 25 - 34 Title/Abstract Full Text Show Details
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Chung, Amanda S. J.; Cheng, Janice N. C.; Tse, Vincent
Current Bladder Dysfunction Reports, 2016 , vol. 11, # 3 p. 258 - 265 Title/Abstract Full Text Show Details
Huang, Jia; Yang, Xin-Hua; Lan, Yong; Zhu, Cui-Ying; Liu, Xiao-Qun; Wang, Ye-Fei; Cheung, Eric F.C.; Xie, Guang-Rong; Chan, Raymond C.K.
Neuropsychology, 2016 , vol. 30, # 6 p. 685 - 696 Title/Abstract Full Text Show Details
Bjarnadottir, Gudrun D.; Magnusson, Andres; Rafnar, Bjarni O.; Sigurdsson, Engilbert; Steingrimsson, Steinn; Johannsson, Magnus; Bragadottir, Helena; Haraldsson, H. Magnus
European Addiction Research, 2016 , vol. 22, # 5 p. 259 - 267 Title/Abstract Full Text Show Details
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Comment (Pharmacological Data)
Bioactivities present
Reference
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International Journal of Neuropsychopharmacology, 2015 , vol. 18, # 3 Title/Abstract Full Text Show Details
Roschlau, Corinna; Votteler, Angeline; Hauber, Wolfgang
Learning and Memory, 2016 , vol. 23, # 8 p. 422 - 426 Title/Abstract Full Text Show Details
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Current Clinical Pharmacology, 2016 , vol. 11, # 2 p. 95 - 109 Title/Abstract Full Text Show Details
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Klein, Tracy A.; Panther, Shannon; Woo, Teri; Odom-Maryon, Tamara; Daratha, Kenn
Journal of Child and Adolescent Psychopharmacology, 2016 , vol. 26, # 6 p. 548 - 554 Title/Abstract Full Text Show Details
Haleem, Darakhshan Jabeen
Current Drug Targets, 2016 , vol. 17, # 11 p. 1282 - 1291 Title/Abstract Full Text Show Details
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Neuromethods, 2016 , vol. 118, p. 1 - 21 Title/Abstract Full Text Show Details
Dyb, Evelyn
International Journal of Drug Policy, 2016 , vol. 36, p. 76 - 84 Title/Abstract Full Text Show Details
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Psychiatry research, 2015 , vol. 229, # 1-2 p. 49 - 56 Title/Abstract Full Text Show Details
Jongkees, Bryant J.; Colzato, Lorenza S.
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Tremblay, Melanie; Winstanley, Catharine A.
Behavioural Brain Research, 2016 , vol. 314, p. 143 - 151 Title/Abstract Full Text Show Details
Ponzoni, Luisa; Sala, Mariaelvina; Braida, Daniela
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World Journal of Biological Psychiatry, 2016 , vol. 17, # 6 p. 406 - 428 Title/Abstract Full Text Show Details
Boronat-García, Alejandra; Palomero-Rivero, Marcela; Guerra-Crespo, Magdalena; Millán-Aldaco, Diana; Drucker-Colín, René
PLoS ONE, 2016 , vol. 11, # 8 art. no. E0160854 Title/Abstract Full Text Show Details
Mai, Bettina; Sommer, Susanne; Hauber, Wolfgang
International Journal of Neuropsychopharmacology, 2015 , vol. 18, # 10 Title/Abstract Full Text Show Details
Sinha; Lewis; Kumar; Yeruva; Curry
Case Reports in Cardiology, 2016 , vol. 2016, art. no. 2343691 Title/Abstract Full Text Show Details
Gentili, Stefano; Solimini, Renata; Tittarelli, Roberta; Mannocchi, Giulio; Busardò, Francesco Paolo
Journal of Analytical Methods in Chemistry, 2016 , vol. 2016, art. no. 1234581 Title/Abstract Full Text Show Details
Kedzierska, Ewa; Wach, Izabela
Current Issues in Pharmacy and Medical Sciences, 2016 , vol. 29, # 2 p. 61 - 65 Title/Abstract Full Text Show Details
67 of 317
Comment (Pharmacological Data)
Bioactivities present
Reference
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Substance Abuse: Treatment, Prevention, and Policy, 2016 , vol. 11, # 1 art. no. 30 Title/Abstract Full Text Show Details
Alremeithi, Rashed H.; Meetani, Mohammed A.; Khalil, Saif. A.
RSC Advances, 2016 , vol. 6, # 84 p. 80576 - 80584 Title/Abstract Full Text Show Details
Gentile, Antonietta; Fresegna, Diego; Musella, Alessandra; Sepman, Helena; Bullitta, Silvia; De Vito, Francesca; Fantozzi, Roberta; Usiello, Alessandro; Maccarrone, Mauro; Mercuri, Nicola B.; Lutz, Beat; Mandolesi, Georgia; Centonze, Diego
Journal of Neuroinflammation, 2016 , vol. 13, # 1 art. no. 231 Title/Abstract Full Text Show Details
Tucker, Murray G.; Kekulawala, Sebastian; Kent, Michelle; Mostafa, Sam; Harvey, Richard
Journal of Medical Case Reports, 2016 , vol. 10, # 1 art. no. 242 Title/Abstract Full Text Show Details
Varriale, Antonio; Marzullo, Vincenzo Manuel; Di Giovanni, Stefano; Scala, Andrea; Capo, Alessandro; Majoli, Adelia; Pennacchio, Angela; Staiano, Maria; D’Auria, Sabato
Analytical and Bioanalytical Chemistry, 2016 , vol. 408, # 23 p. 6329 - 6336 Title/Abstract Full Text Show Details
Varriale, Antonio; Marzullo, Vincenzo Manuel; Di Giovanni, Stefano; Scala, Andrea; Capo, Alessandro; Majoli, Adelia; Pennacchio, Angela; Staiano, Maria; D’Auria, Sabato
Analytical and Bioanalytical Chemistry, 2016 , vol. 408, # 23 p. 6329 - 6336 Title/Abstract Full Text Show Details
Wearne, Travis A.; Parker, Lindsay M.; Franklin, Jane L.; Goodchild, Ann K.; Cornish, Jennifer L.
Neuropharmacology, 2016 , vol. 111, p. 107 - 118 Title/Abstract Full Text Show Details
Parr, Maria Kristina; Wuest, Bernhard; Naegele, Edgar; Joseph, Jan F.; Wenzel, Maxi; Schmidt, Alexander H.; Stanic, Mijo; de la Torre, Xavier; Botrè, Francesco
Analytical and Bioanalytical Chemistry, 2016 , vol. 408, # 24 p. 6789 - 6797 Title/Abstract Full Text Show Details
Parr, Maria Kristina; Wuest, Bernhard; Naegele, Edgar; Joseph, Jan F.; Wenzel, Maxi; Schmidt, Alexander H.; Stanic, Mijo; de la Torre, Xavier; Botrè, Francesco
Analytical and Bioanalytical Chemistry, 2016 , vol. 408, # 24 p. 6789 - 6797 Title/Abstract Full Text Show Details
Sárvári, Miklós; Deli, Levente; Kocsis, Pál; Márk, László; Maász, Gábor; Hrabovszky, Erik; Kalló, Imre; Gajári, Dávid; Vastagh, Csaba; Sümegi, Balázs; Tihanyi, Károly; Liposits, Zsolt
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Golovko; Bonitenko, E. Yu.; Ivanov; Barinov; Zatsepin
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Cope, Zackary A.; Halberstadt, Adam L.; van Enkhuizen, Jordy; Flynn, Aaron D.; Breier, Michelle; Swerdlow, Neal R.; Geyer, Mark A.; Young, Jared W.
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Hambuchen, Michael D.; Rüedi-Bettschen, Daniela; Gunnell, Melinda G.; Hendrickson, Howard; Owens, S. Michael
Human Vaccines and Immunotherapeutics, 2016 , vol. 12, # 9 p. 2240 - 2248 Title/Abstract Full Text Show Details
Cansell; Castel; Denis; Rouch; Delbes; Martinez; Mestivier; Finan; Maldonado-Aviles; Rijnsburger; Tschöp; DiLeone; Eckel; La Fleur; Magnan; Hnasko; Luquet
Molecular Psychiatry, 2014 , vol. 19, # 10 p. 1095 - 1105 Title/Abstract Full Text Show Details
Papaseit, Esther; Pérez-Mañá, Clara; Mateus, Julián-Andrés; Pujadas, Mitona; Fonseca, Francina; Torrens, Marta; Olesti, Eulàlia; De La Torre, Rafael; Farre, Magi
Neuropsychopharmacology, 2016 , vol. 41, # 11 p. 2704 - 2713 Title/Abstract Full Text Show Details
Cooke, Tommi; So, Tsz-Yin
Current Pediatric Reviews, 2016 , vol. 12, # 3 p. 230 - 238 Title/Abstract Full Text Show Details
Dupuis, Marc; Baggio, Stéphanie; Accard, Marion Emilie; Mohler-Kuo, Meichun; Gmel, Gerhard
Drugs and Alcohol Today, 2016 , vol. 16, # 3 p. 212 - 221 Title/Abstract Full Text Show Details
Noven Pharmaceuticals, Inc.; Liu, Puchun; Dinh, Steven; Liao, Jun; Endo, Tsuyoshi
Patent: US2016/256406 A1, 2016 ; Title/Abstract Full Text Show Details
Bershad, Anya K.; Weafer, Jessica J.; Kirkpatrick, Matthew G.; Wardle, Margaret C.; Miller, Melissa A.; de Wit, Harriet
Social Neuroscience, 2016 , vol. 11, # 6 p. 592 - 599 Title/Abstract Full Text Show Details
Mowry, James B.; Spyker, Daniel A.; Cantilena, Louis R.; McMillan, Naya; Ford, Marsha
Clinical Toxicology, 2014 , vol. 52, # 10 p. 1032 - 1283 Title/Abstract Full Text Show Details
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Comment (Pharmacological Data)
Bioactivities present
Reference
Kumar, Nihit; Stowe, Zachary N.; Han, Xiaotong; Mancino, Michael J.
American Journal on Addictions, 2016 , vol. 25, # 7 p. 542 - 548 Title/Abstract Full Text Show Details
Lai, Wen-Sung; Chang, Chia-Yuan; Wong, Wan-Rong; Pei, Ju-Chun; Chen, Ya-Shan; Hung, Wei-Li
Current Pharmaceutical Design, 2014 , vol. 20, # 32 p. 5139 - 5149 Title/Abstract Full Text Show Details
Heravi, Majid M.; Zadsirjan, Vahideh; Dehghani, Mahzad
Current Organic Chemistry, 2016 , vol. 20, # 10 p. 1069 - 1134 Title/Abstract Full Text Show Details
Thomaidis, Nikolaos S.; Gago-Ferrero, Pablo; Ort, Christoph; Maragou, Niki C.; Alygizakis, Nikiforos A.; Borova, Viola L.; Dasenaki, Marilena E.
Environmental Science and Technology, 2016 , vol. 50, # 18 p. 10065 - 10072 Title/Abstract Full Text Show Details
González-Mariño, Iria; Gracia-Lor, Emma; Rousis, Nikolaos I.; Castrignanò, Erika; Thomas, Kevin V.; Quintana, José Benito; Kasprzyk-Hordern, Barbara; Zuccato, Ettore; Castiglioni, Sara
Environmental Science and Technology, 2016 , vol. 50, # 18 p. 10089 - 10096 Title/Abstract Full Text Show Details
Aotani, Daisuke; Son, Cheol; Shimizu, Yoshiyuki; Nomura, Hidenari; Hikida, Takatoshi; Kusakabe, Toru; Tanaka, Tomohiro; Miyazawa, Takashi; Hosoda, Kiminori; Nakao, Kazuwa
Neuroscience Letters, 2016 , vol. 633, p. 141 - 145 Title/Abstract Full Text Show Details
Petrie, Bruce; Gravell, Anthony; Mills, Graham A.; Youdan, Jane; Barden, Ruth; Kasprzyk-Hordern, Barbara
Environmental Science and Technology, 2016 , vol. 50, # 17 p. 9469 - 9478 Title/Abstract Full Text Show Details
Hamilton, Peter J.; Shekar, Aparna; Belovich, Andrea N.; Christianson, Nicole Bibus; Campbell, Nicholas G.; Sutcliffe, James S.; Galli, Aurelio; Matthies, Heinrich J.G.; Erreger, Kevin
Molecular Autism, 2015 , vol. 6, # 1 art. no. 8 Title/Abstract Full Text Show Details
Schacht
Pharmacogenomics Journal, 2016 , vol. 16, # 5 p. 430 - 438 Title/Abstract Full Text Show Details
Dougherty, Casey A.; Cai, Weibo; Hong, Hao
Current Topics in Medicinal Chemistry, 2015 , vol. 15, # 12 p. 1138 - 1152 Title/Abstract Full Text Show Details
Moreira, Rodrigo V.; da Costa, José L.; Menezes, Mauro R.; de Faria, Dalva L.A.
Vibrational Spectroscopy, 2016 , vol. 87, p. 104 - 110 Title/Abstract Full Text Show Details
Høiseth, Gudrun; Tuv, Silja Skogstad; Karinen, Ritva
Forensic Science International, 2016 , vol. 268, p. 35 - 38 Title/Abstract Full Text Show Details
Larney, Sarah; Mathers, Bradley M.; Poteat, Tonia; Kamarulzaman, Adeeba; Degenhardt, Louisa
Journal of Acquired Immune Deficiency Syndromes, 2015 , vol. 69, p. S100 - S109 Title/Abstract Full Text Show Details
Lee, Sylvia S.; Paspalof, Alexis M.; Snow, Daniel D.; Richmond, Erinn K.; Rosi-Marshall, Emma J.; Kelly, John J.
Environmental Science and Technology, 2016 , vol. 50, # 17 p. 9727 - 9735 Title/Abstract Full Text Show Details
Getasetegn, Million
Phytochemistry Reviews, 2016 , vol. 15, # 5 p. 907 - 920 Title/Abstract Full Text Show Details
Mazitov, Timur; Bregin, Aleksandr; Philips, Mari-Anne; Innos, Jürgen; Vasar, Eero
Behavioural Brain Research, 2017 , vol. 317, p. 311 - 318 Title/Abstract Full Text Show Details
Fosnocht, Anne Q.; Briand, Lisa A.
Physiology and Behavior, 2016 , vol. 166, p. 32 - 42 Title/Abstract Full Text Show Details
Beloate, Lauren N.; Omrani, Azar; Adan, Roger A.; Webb, Ian C.; Coolen, Lique M.
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Title/Abstract Full Text Show Details
Barnum, Richard
Adolescent Health, Medicine and Therapeutics, 2014 , vol. 5, p. 67 - 71 Title/Abstract Full Text Show Details
Righi, Federica; Polidori, Edoardo; Valletta, Enrico
Quaderni ACP, 2016 , vol. 23, # 5 p. 207 - 210 Title/Abstract Full Text Show Details
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70 of 317
Comment (Pharmacological Data)
Bioactivities present
Reference
Görgens, Christian; Guddat, Sven; Thomas, Andreas; Wachsmuth, Philipp; Orlovius, Anne-Katrin; Sigmund, Gerd; Thevis, Mario; Schänzer, Wilhelm
Journal of Pharmaceutical and Biomedical Analysis, 2016 , vol. 131, p. 482 - 496 Title/Abstract Full Text Show Details
Rezaei, Farzin; Emami, Maryam; Zahed, Shakiba; Morabbi, Mohammad-Javad; Farahzadi, Mohammadhadi; Akhondzadeh, Shahin
DARU, Journal of Pharmaceutical Sciences, 2015 , vol. 23, # 1 art. no. 2 Title/Abstract Full Text Show Details
Wright, Jackie; Edwards, John; Walker, Stewart
Reviews on Environmental Health, 2016 , vol. 31, # 3 p. 329 - 352 Title/Abstract Full Text Show Details
Philippu, Athineos
Current Medicinal Chemistry, 2016 , vol. 23, # 24 p. 2643 - 2652 Title/Abstract Full Text Show Details
Pitsikas, Nikolaos
Current Medicinal Chemistry, 2016 , vol. 23, # 24 p. 2692 - 2705 Title/Abstract Full Text Show Details
Woźniak, Monika; Acher, Francine; Marciniak, Marcin; Łasoń-Tyburkiewicz, Magdalena; Gruca, Piotr; Papp, Mariusz; Pilc, Andrzej; Wierońska, Joanna M.
Current Neuropharmacology, 2016 , vol. 14, # 5 p. 413 - 426 Title/Abstract Full Text Show Details
Hamidi, Samin; Khoubnasabjafari, Maryam; Ansarin, Khalil; Jouyban-Gharamaleki, Vahid; Jouyban, Abolghasem
Current Pharmaceutical Analysis, 2016 , vol. 12, # 2 p. 137 - 145 Title/Abstract Full Text Show Details
Ramachandra
Critical Reviews in Analytical Chemistry, 2016 , vol. 46, # 6 p. 482 - 489 Title/Abstract Full Text Show Details
Camacho-Muñoz, Dolores; Petrie, Bruce; Castrignanò, Erika; Kasprzyk-Hordern, Barbara
Current Analytical Chemistry, 2016 , vol. 12, # 4 p. 303 - 314 Title/Abstract Full Text Show Details
Baalbaki, Zeina; Sultana, Tamanna; Maere, Thomas; Vanrolleghem, Peter A.; Metcalfe, Chris D.; Yargeau, Viviane
Science of the Total Environment, 2016 , vol. 573, p. 1147 - 1158 Title/Abstract Full Text Show Details
Estrada-Arriaga, Edson Baltazar; Cortés-Muñoz, Juana Enriqueta; González-Herrera, Arturo; Calderón-Mólgora, César Guillermo; de Lourdes Rivera-Huerta, Ma.; Ramírez-Camperos, Esperanza; Montellano-Palacios, Leticia; Gelover-Santiago, Silvia Lucila; Pérez-Castrejón, Sara; Cardoso-Vigueros, Lina; Martín-Domínguez, Alejandra; García-Sánchez, Liliana
Science of the Total Environment, 2016 , vol. 571, p. 1172 - 1182 Title/Abstract Full Text Show Details
Weyandt, Lisa L.; Oster, Danielle R.; Marraccini, Marisa E.; Gudmundsdottir, Bergljot Gyda; Munro, Bailey A.; Rathkey, Emma S.; McCallum, Alison
Experimental and Clinical Psychopharmacology, 2016 , vol. 24, # 5 p. 400 - 414 Title/Abstract Full Text Show Details
Meyer, Markus R.
Archives of Toxicology, 2016 , vol. 90, # 10 p. 2421 - 2444 Title/Abstract Full Text Show Details
Soussan, Christophe; Kjellgren, Anette
International Journal of Drug Policy, 2016 , vol. 32, p. 77 - 84 Title/Abstract Full Text Show Details
Oswald, Lynn M.; Wand, Gary S.
NeuroImage, 2016 , vol. 125, p. 1096 - 1098 Title/Abstract Full Text Show Details
Caudevilla, Fernando; Ventura, Mireia; Fornís, Iván; Barratt, Monica J.; Vidal, Claudio; lladanosa, Cristina Gil; Quintana, Pol; Muñoz, Ana; Calzada, Nuria
International Journal of Drug Policy, 2016 , vol. 35, p. 38 - 41 Title/Abstract Full Text Show Details
Banks, Matthew L.
Drug and Alcohol Dependence, 2016 , vol. 165, p. 260 - 264 Title/Abstract Full Text Show Details
Kankaanpää, Aino; Ariniemi, Kari; Heinonen, Mari; Kuoppasalmi, Kimmo; Gunnar, Teemu
Science of the Total Environment, 2016 , vol. 568, p. 864 - 874 Title/Abstract Full Text Show Details
van Wel; Kinyua; van Nuijs; Salvatore; Bramness; Covaci; Van Hal
International Journal of Drug Policy, 2016 , vol. 34, p. 20 - 26 Title/Abstract Full Text Show Details
Lile, Joshua A.; Stoops, William W.; Rush, Craig R.; Negus, S. Stevens; Glaser, Paul E.A.; Hatton, Kevin W.; Hays, Lon R.
Drug and Alcohol Dependence, 2016 , vol. 165, p. 111 - 119 Title/Abstract Full Text Show Details
Comment (Pharmacological Data)
Bioactivities present
Reference
Karkhanis, Anushree N.; Beveridge, Thomas J.R.; Blough, Bruce E.; Jones, Sara R.; Ferris, Mark J.
Drug and Alcohol Dependence, 2016 , vol. 166, p. 51 - 60 Title/Abstract Full Text Show Details
Managò, Francesca; Mereu, Maddalena; Mastwal, Surjeet; Mastrogiacomo, Rosa; Scheggia, Diego; Emanuele, Marco; De Luca, Maria A.; Weinberger, Daniel R.; Wang, Kuan Hong; Papaleo, Francesco
Cell Reports, 2016 , vol. 16, # 8 p. 2116 - 2128 Title/Abstract Full Text Show Details
Tierney, Aaron A.; Hart, Carl L.
NeuroImage, 2016 , vol. 125, p. 1095 - 1095 Title/Abstract Full Text Show Details
Lander, Sharon S.; Linder-Shacham, Donna; Gaisler-Salomon, Inna
Behavioural Brain Research, 2017 , vol. 316, p. 245 - 254 Title/Abstract Full Text Show Details
Telving, Rasmus; Hasselstrøm, Jørgen Bo; Andreasen, Mette Findal
Forensic Science International, 2016 , vol. 266, p. 453 - 461 Title/Abstract Full Text Show Details
Kyriakou, Chrystalla; Marchei, Emilia; Scaravelli, Giulia; García-Algar, Oscar; Supervía, August; Graziano, Silvia
Journal of Pharmaceutical and Biomedical Analysis, 2016 , vol. 128, p. 53 - 60 Title/Abstract Full Text Show Details
Gicquel, Thomas; Hugbart, Chloé; Le Devehat, Françoise; Lepage, Sylvie; Baert, Alain; Bouvet, Renaud; Morel, Isabelle
Forensic Science International, 2016 , vol. 266, p. e38 - e42 Title/Abstract Full Text Show Details
El-Mallakh, Rif S.; Roberts, R. Jeannie; El-Mallakh, Peggy L.; Findlay, Lillian Jan; Reynolds, Kristen K.
Clinics in Laboratory Medicine, 2016 , vol. 36, # 3 p. 507 - 523 Title/Abstract Full Text Show Details
Daneschvar, Homayoun L.; Aronson, Mark D.; Smetana, Gerald W.
American Journal of Medicine, 2016 , vol. 129, # 8 p. 1 - 6,879 Title/Abstract Full Text Show Details
Peleg-Raibstein; Sarker; Litwan; Krämer; Ametamey; Schibli; Wolfrum
Translational Psychiatry, 2016 , vol. 6, # 10 art. no. E911 Title/Abstract Full Text Show Details
Hussain, Shahzad; Khattak, Zainab; Mahmood, Sidra; Malik, Farnaz; Riaz, Humayun; Raza, Syed Atif; Khan, Samiullah
Pakistan Journal of Pharmaceutical Sciences, 2016 , vol. 29, # 5 p. 1639 - 1648 Title/Abstract Full Text Show Details
Gentili, Stefano; Mortali, Claudia; Mastrobattista, Luisa; Berretta, Paolo; Zaami, Simona
Journal of Pharmaceutical and Biomedical Analysis, 2016 , vol. 129, p. 282 - 287 Title/Abstract Full Text Show Details
Spiegel, David R.; McCroskey, Aidan; Puaa, Kapaakea; Meeker, Grant; Hartman, Lauren; Hudson, Joshua; Hung, Yu C.
Clinical Neuropharmacology, 2016 , vol. 39, # 5 p. 272 - 275 Title/Abstract Full Text Show Details
Pike, Erika; Stoops, William W.; Rush, Craig R.
Pharmacology Biochemistry and Behavior, 2016 , vol. 150-151, p. 87 - 93 Title/Abstract Full Text Show Details
Nikfarjam, Ali; Shokoohi, Mostafa; Shahesmaeili, Armita; Haghdoost, Ali Akbar; Baneshi, Mohammad Reza; Haji-Maghsoudi, Saiedeh; Rastegari, Azam; Nasehi, Abbas Ali; Memaryan, Nadereh; Tarjoman, Termeh
International Journal of Drug Policy, 2016 , vol. 31, p. 147 - 152 Title/Abstract Full Text Show Details
Lee, Hun Joo; Han, Eunyoung; Lee, Jaesin; Chung, Heesun; Min, Sung-Gi
Forensic Science International, 2016 , vol. 268, p. 116 - 122 Title/Abstract Full Text Show Details
Donegani, Enrico; Paal, Peter; Küpper, Thomas; Hefti, Urs; Basnyat, Buddha; Carceller, Anna; Bouzat, Pierre; Van Der Spek, Rianne; Hillebrandt, David
High Altitude Medicine and Biology, 2016 , vol. 17, # 3 p. 157 - 184 Title/Abstract Full Text Show Details
Hussain; Cossette; Brake
Journal of Neuroendocrinology, 2016 , vol. 28, # 5 p. 10 Title/Abstract Full Text Show Details
Alessandri, Ivano; Vassalini, Irene; Bertuzzi, Michela; Bontempi, Nicolò; Memo, Maurizio; Gianoncelli, Alessandra
Scientific Reports, 2016 , vol. 6, art. no. 34521 Title/Abstract Full Text Show Details
Volkow; Wang; Logan; Alexoff; Fowler; Thanos; Wong; Casado; Ferre; Tomasi
Translational Psychiatry, 2015 , vol. 5, # 4 art. no. A046 Title/Abstract Full Text Show Details
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Comment (Pharmacological Data)
Bioactivities present
Reference
Andrés-Costa, María Jesús; Andreu, Vicente; Picó, Yolanda
Journal of Chromatography A, 2016 , vol. 1461, p. 98 - 106 Title/Abstract Full Text Show Details
Punja, Salima; Schmid, Christopher H.; Hartling, Lisa; Urichuk, Liana; Nikles, Catherine Jane; Vohra, Sunita
Journal of Clinical Epidemiology, 2016 , vol. 76, p. 76 - 81 Title/Abstract Full Text Show Details
Freeman; Rice; Soto; Pate; Weed; Ator; DeLeon; Wong; Zhou; Mankowski; Zink; Adams; Hutchinson
Translational Psychiatry, 2015 , vol. 5, # 5 art. no. E567 Title/Abstract Full Text Show Details
Smucny; Stevens; Olincy; Tregellas
Translational Psychiatry, 2015 , vol. 5, # 6 art. no. E587 Title/Abstract Full Text Show Details
Li; Leung; Zhou; Ho; Kong; Basil; Wei; Lam; Zhang; Law; Chua; Sham; Wu; McAlonan
Translational Psychiatry, 2015 , vol. 5, # 9 art. no. E641 Title/Abstract Full Text Show Details
Punja, Salima; Xu, Dongying; Schmid, Christopher H.; Hartling, Lisa; Urichuk, Liana; Nikles, Catherine Jane; Vohra, Sunita
Journal of Clinical Epidemiology, 2016 , vol. 76, p. 65 - 75 Title/Abstract Full Text Show Details
Jin, Yunju; Dougherty, Sarah E.; Wood, Kevin; Sun, Landy; Cudmore, Robert H.; Abdalla, Aya; Kannan, Geetha; Pletnikov,
Mikhail; Hashemi, Parastoo; Linden, David J.
Neuron, 2016 , vol. 91, # 4 p. 748 - 762 Title/Abstract Full Text Show Details
Saz; Marina
Journal of Chromatography A, 2016 , vol. 1467, p. 79 - 94 Title/Abstract Full Text Show Details
Gan, Jinping; Ma, Shuguang; Zhang, Donglu
Drug Metabolism Reviews, 2016 , vol. 48, # 4 p. 473 - 501 Title/Abstract Full Text Show Details
Posadzki, Pawel; Khalil, Mohamed M. K.; AlBedah, Abdullah M. N.; Zhabenko, Olena; Car, Josip
Focus on Alternative and Complementary Therapies, 2016 , vol. 21, # 2 p. 69 - 81 Title/Abstract Full Text Show Details
Hyun, Myung Ho
Journal of Chromatography A, 2016 , vol. 1467, p. 19 - 32 Title/Abstract Full Text Show Details
Bäckberg, Matilda; Westerbergh, Jenny; Beck, Olof; Helander, Anders
Clinical Toxicology, 2016 , vol. 54, # 9 p. 819 - 825 Title/Abstract Full Text Show Details
Cumming, Craig; Troeung, Lakkhina; Young, Jesse T.; Kelty, Erin; Preen, David B.
Drug and Alcohol Dependence, 2016 , vol. 168, p. 263 - 273 Title/Abstract Full Text Show Details
Ford, Loretta T; Berg, Jonathan D
Annals of Clinical Biochemistry, 2016 , vol. 53, # 6 p. 640 - 646 Title/Abstract Full Text Show Details
Priebe, Stefan; Bremner, Stephen A.; Lauber, Christoph; Henderson, Catherine; Burns, Tom
Health Technology Assessment, 2016 , vol. 20, # 70 p. v Title/Abstract Full Text Show Details
Foster, Daniel J.; Wilson, Jermaine M.; Remke, Daniel H.; Mahmood, M. Suhaib; Uddin, M. Jashim; Wess, Jürgen; Patel, Sachin; Marnett, Lawrence J.; Niswender, Colleen M.; Jones, Carrie K.; Xiang, Zixiu; Lindsley, Craig W.; Rook, Jerri M.; Conn, P. Jeffrey
Neuron, 2016 , vol. 91, # 6 p. 1244 - 1252 Title/Abstract Full Text Show Details
Cunningham, Scott; Finlay, Keith
Health Economics (United Kingdom), 2016 , vol. 25, # 10 p. 1268 - 1290 Title/Abstract Full Text Show Details
Jain; Arya; Inamdar; Auti; Unawane; Puranik; Sanap; Inamke; Mahale; Prajapati; Shishoo
Current Topics in Medicinal Chemistry, 2016 , vol. 16, # 28 p. 3133 - 3174 Title/Abstract Full Text Show Details
Kristofic, John J.; Chmiel, Jeffrey D.; Jackson, George F.; Vorce, Shawn P.; Holler, Justin M.; Robinson, Stephen L.; Bosy, Thomas Z.
Journal of Analytical Toxicology, 2016 , vol. 40, # 6 art. no. BKW035, p. 466 - 472 Title/Abstract Full Text Show Details
Vijayakumar, Arumugam Ramamoorthy; Biswas, Nihar Ranjan; Menon, Vimla; Saxena, Rohit; Ahmed, Warisha; Halder, Nabanita; Velpandian, Thirumurthy
Indian Journal of Physiology and Pharmacology, 2016 , vol. 60, # 2 p. 182 - 192 Title/Abstract Full Text Show Details
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Comment (Pharmacological Data)
Bioactivities present
Reference
Arredondo, Cristian; González, Marcela; Andrés, María Estela; Gysling, Katia
Brain Research, 2016 , vol. 1652, p. 14 - 20 Title/Abstract Full Text Show Details
Amin, Bahareh; Andalib, Sasan; Vaseghi, Golnaz; Mesripour, Azadeh
Iranian Journal of Psychiatry and Behavioral Sciences, 2016 , vol. 10, # 2 art. no. E1822 Title/Abstract Full Text Show Details
Peng, Yan; Hall, Sarah; Gautam, Lata
TrAC - Trends in Analytical Chemistry, 2016 , vol. 85, p. 232 - 240 Title/Abstract Full Text Show Details
Haglock-Adler, Carrie J.; McMillin, Gwendolyn A.; Strathmann, Frederick G.
Clinical Biochemistry, 2016 , vol. 49, # 13-14 p. 1092 - 1095 Title/Abstract Full Text Show Details
Kueh, Shaw-Hua (Anthony); Gabriel, Ruvin S.; Lund, Mayanna; Sutton, Tim; Bradley, Joshua; Kerr, Andrew J.; Looi, Jen-Li
Heart Lung and Circulation, 2016 , vol. 25, # 11 p. 1087 - 1093 Title/Abstract Full Text Show Details
Kang, Shuo; Wu, Mariah M.; Galvez, Roberto; Gulley, Joshua M.
Neuroscience, 2016 , vol. 339, p. 72 - 84 Title/Abstract Full Text Show Details
Amador, Ariadna; Huitron-Resendiz, Salvador; Roberts, Amanda J.; Kamenecka, Theodore M.; Solt, Laura A.; Burris, Thomas P. Burris
PLoS ONE, 2016 , vol. 11, # 9 art. no. E0162452 Title/Abstract Full Text Show Details
Castello, Stefania; D'Aloisio, Genesis; Arias, Carlos; Molina, Juan Carlos
Pharmacology Biochemistry and Behavior, 2016 , vol. 150-151, p. 68 - 75 Title/Abstract Full Text Show Details
Asser, Andres; Kõks, Sulev; Snellman, Anniina; Haaparanta-Solin, Merja; Arponen, Eveliina; Grönroos, Tove; Nairismägi, Jaak; Bergquist, Jonas; Soomets, Ursel; Piip, Piret; Eltermaa, Mall; Sauk, Martin; Lindmäe, Hanna; Rinne, Juha O.; Taba, Pille
Brain Research, 2016 , vol. 1652, p. 97 - 102 Title/Abstract Full Text Show Details
Salomone; Tsanaclis; Agius; Kintz; Baumgartner
Drug Testing and Analysis, 2016 , vol. 8, # 10 p. 996 - 1004 Title/Abstract Full Text Show Details
Chiu, Zelia K.; Bennett, Iwan E.; Chan, Patrick; Rosenfeld, Jeffrey V.
Journal of Clinical Neuroscience, 2016 , vol. 32, p. 137 - 139
Title/Abstract Full Text Show Details
Vanderschuren, Louk J.M.J.; Achterberg, E.J. Marijke; Trezza, Viviana
Neuroscience and Biobehavioral Reviews, 2016 , vol. 70, p. 86 - 105 Title/Abstract Full Text Show Details
Spear, Linda Patia
Neuroscience and Biobehavioral Reviews, 2016 , vol. 70, p. 228 - 243 Title/Abstract Full Text Show Details
Bumbrah, Gurvinder Singh; Sharma, Rakesh Mohan
Egyptian Journal of Forensic Sciences, 2016 , vol. 6, # 3 p. 209 - 215 Title/Abstract Full Text Show Details
Mychasiuk, Richelle; Metz, Gerlinde A.S.
Neuroscience and Biobehavioral Reviews, 2016 , vol. 70, p. 189 - 197 Title/Abstract Full Text Show Details
Beerepoot, Pieter; Lam, Vincent M.; Salahpour, Ali
Journal of Biological Chemistry, 2016 , vol. 291, # 42 p. 22053 - 22062 Title/Abstract Full Text Show Details
Kutlu, Munir Gunes; Gould, Thomas J.
Learning and Memory, 2016 , vol. 23, # 10 p. 515 - 533 Title/Abstract Full Text Show Details
Lang, Juliane; Dettmeyer, Reinhard; Henn, Veroniqué; Birngruber, Christoph G.; Veit, Florian
Romanian Journal of Legal Medicine, 2016 , vol. 24, # 3 p. 212 - 215 Title/Abstract Full Text Show Details
Wiergowski, Marek; Anand, Jacek Sein; Karnecki, Karol; Sołtyszewski, Ireneusz; Jankowski, Zbigniew
Romanian Journal of Legal Medicine, 2016 , vol. 24, # 3 p. 219 - 225 Title/Abstract Full Text Show Details
Drinkenburg, Wilhelmus H.I.M.; Ruigt, Gé S.F.; Ahnaou, Abdallah
Neuropsychobiology, 2016 , vol. 72, # 3-4 p. 151 - 164 Title/Abstract Full Text Show Details
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Comment (Pharmacological Data)
Bioactivities present
Reference
Feng, Ling-Yi; Yu, Wen-Jing; Chang, Wei-Ting; Han, Eunyoung; Chung, Heesun; Li, Jih-Heng
Substance Abuse: Treatment, Prevention, and Policy, 2016 , vol. 11, # 1 art. no. 34 Title/Abstract Full Text Show Details
Thorley, Emma; Kang, Isaac; D'Costa, Stephanie; Vlazaki, Myrto; Ayeko, Olaoluwa; Arbe-Barnes, Edward H.; Swerner, Casey B.
Philosophy, Ethics, and Humanities in Medicine, 2016 , vol. 11, # 1 art. no. 6 Title/Abstract Full Text Show Details
Milienne-Petiot, Morgane; Kesby, James P.; Graves, Mary; van Enkhuizen, Jordy; Semenova, Svetlana; Minassian, Arpi; Markou, Athina; Geyer, Mark A.; Young, Jared W.
Neuropharmacology, 2017 , vol. 113, p. 260 - 270 Title/Abstract Full Text Show Details
Trossbach; Bader; Hecher; Pum; Masoud; Prikulis; Schäble; De Souza Silva; Su; Boulat; Chwiesko; Poschmann; Stühler; Lohr; Stout; Oskamp; Godsave; Müller-Schiffmann; Bilzer; Steiner; Peters; Bauer; Sauvage; Ramsey; Miller; Liu; Seeman; Brandon; Huston; Korth
Molecular Psychiatry, 2016 , vol. 21, # 11 p. 1561 - 1572 Title/Abstract Full Text Show Details
Andersen, Jacob; Ladefoged, Lucy Kate; Kristensen, Trine N. Bjerre; Munro, Lachlan; Grouleff, Julie; Stuhr-Hansen, Nicolai; Kristensen, Anders S.; Schiøtt, Birgit; Strømgaard, Kristian
ACS Chemical Neuroscience, 2016 , vol. 7, # 10 p. 1406 - 1417 Title/Abstract Full Text Show Details
Nieddu, Maria; Burrai, Lucia; Baralla, Elena; Pasciu, Valeria; Varoni, Maria Vittoria; Briguglio, Irene; Demontis, Maria Piera; Boatto, Gianpiero
Journal of Analytical Toxicology, 2016 , vol. 40, # 7 p. 492 - 497 Title/Abstract Full Text Show Details
Mallet, Claude; Botch-Jones, Sabra
Journal of Analytical Toxicology, 2016 , vol. 40, # 8 art. no. BKW082, p. 617 - 627 Title/Abstract Full Text Show Details
Rosano, Thomas G.; Ohouo, Patrice Y.; LeQue, John J.; Freeto, Scott M.; Wood, Michelle
Journal of Analytical Toxicology, 2016 , vol. 40, # 8 art. no. BKW050, p. 628 - 638 Title/Abstract Full Text Show Details
Gogliotti, Rocco G.; Senter, Rebecca K.; Rook, Jerri M.; Ghoshal, Ayan; Zamorano, Rocio; Malosh, Chrysa; Stauffer, Shaun R.; Bridges, Thomas M.; Bartolome, Jose M.; Daniels, J. Scott; Jones, Carrie K.; Lindsley, Craig W.; Conn, P. Jeffrey; Niswender, Colleen M.
Human Molecular Genetics, 2016 , vol. 25, # 10 art. no. DDW074, p. 1990 - 2004 Title/Abstract Full Text Show Details
Fassette, Timothy; Martinez, Afton
Journal of Analytical Toxicology, 2016 , vol. 40, # 8 art. no. BKW054, p. 700 - 702 Title/Abstract Full Text Show Details
Morozova, Ekaterina; Yoo, Yeonjoo; Behrouzvaziri, Abolhassan; Zaretskaia, Maria; Rusyniak, Daniel; Zaretsky, Dmitry; Molkov, Yaroslav
Physiological Reports, 2016 , vol. 4, # 17 art. no. E12955 Title/Abstract Full Text Show Details
Mellsop, Graham; Choi; Every-Palmer, Susanna; Green, Bob; Heffernan, Ed; Kachaeva, Margarita; Shiina, Akihiro; Wang, Xiaoping
International Journal of Law and Psychiatry, 2016 , vol. 47, p. 68 - 73 Title/Abstract Full Text Show Details
Ceretta, Ana Paula Chiapinotto; Schaffer, Larissa Finger; de Freitas, Catiuscia Molz; Reinheimer, Jeane Binotto; Dotto, Mariana Maikéli; Fachinetto, Roselei
Schizophrenia Research, 2016 , vol. 175, # 1-3 p. 230 - 231 Title/Abstract Full Text Show Details
Engelke, Douglas Senna; Filev, Renato; Mello, Luiz E.; Santos-Junior, Jair Guilherme
Behavioural Brain Research, 2017 , vol. 317, p. 522 - 527 Title/Abstract Full Text Show Details
Thevis, Mario; Geyer, Hans; Tretzel, Laura; Schänzer, Wilhelm
Journal of Pharmaceutical and Biomedical Analysis, 2016 , vol. 130, p. 220 - 230 Title/Abstract Full Text Show Details
Kailasa, Suresh Kumar; Wu, Hui-Fen
Current Neuropharmacology, 2013 , vol. 11, # 4 p. 436 - 464 Title/Abstract Full Text Show Details
Khalilian, Faezeh; Rezaee, Mohammad
Journal of the Brazilian Chemical Society, 2016 , vol. 27, # 11 p. 2105 - 2113 Title/Abstract Full Text Show Details
Mercolini, Laura; Protti, Michele
Journal of Pharmaceutical and Biomedical Analysis, 2016 , vol. 130, p. 202 - 219 Title/Abstract Full Text Show Details
Sealover, Natalie R.; Felts, Bruce; Kuntz, Charles P.; Jarrard, Rachel E.; Hockerman, Gregory H.; Barker, Eric L.; Henry, L. Keith
Biochemical Pharmacology, 2016 , vol. 120, p. 46 - 55 Title/Abstract Full Text Show Details
Simonsen, Ulf; Comerma-Steffensen, Simon; Andersson, Karl-Erik
Basic and Clinical Pharmacology and Toxicology, 2016 , vol. 119, p. 63 - 74 Title/Abstract Full Text Show Details
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Comment (Pharmacological Data)
Bioactivities present
Reference
Shin, Eun-Joo; Nam, Yunsung; Lee, Ji Won; Nguyen, Phuong-Khue Thi; Yoo, Ji Eun; Tran, The-Vinh; Jeong, Ji Hoon; Jang, Choon-Gon; Oh, Young J.; Youdim, Moussa B. H.; Lee, Phil Ho; Nabeshima, Toshitaka; Kim, Hyoung-Chun
Molecular Neurobiology, 2016 , vol. 53, # 9 p. 6251 - 6269 Title/Abstract Full Text Show Details
Krauss, Shannon T.; Remcho, Thomas P.; Lipes, Shelby M.; Aranda, Roman; Maynard, Henry P.; Shukla, Nishant; Li, Jingyi; Tontarski, Richard E.; Landers, James P.
Analytical Chemistry, 2016 , vol. 88, # 17 p. 8689 - 8697 Title/Abstract Full Text Show Details
Rentsch, Katharina M.
TrAC - Trends in Analytical Chemistry, 2016 , vol. 84, p. 88 - 93 Title/Abstract Full Text Show Details
Bhattacharjee, Nivedita; Borah, Anupom
Neurochemistry International, 2016 , vol. 101, p. 48 - 55 Title/Abstract Full Text Show Details
Singer, Bryan F.; Bubula, Nancy; Przybycien-Szymanska, Magdalena M.; Li, Dongdong; Vezina, Paul
European Neuropsychopharmacology, 2016 , vol. 26, # 11 p. 1836 - 1842 Title/Abstract Full Text Show Details
Guatteo, Ezia; Rizzo, Francesca Romana; Federici, Mauro; Cordella, Alberto; Ledonne, Ada; Latini, Laura; Nobili, Annalisa; Viscomi, Maria Teresa; Biamonte, Filippo; Landrock, Kerstin K.; Martini, Alessandro; Aversa, Daniela; Schepisi, Chiara; D'Amelio, Marcello; Berretta, Nicola; Mercuri, Nicola B.
Experimental Neurology, 2017 , vol. 287, p. 21 - 33 Title/Abstract Full Text Show Details
Vicente-Rodríguez, Marta; Rojo Gonzalez, Loreto; Gramage, Esther; Fernández-Calle, Rosalía; Chen, Ying; Pérez-García, Carmen; Ferrer-Alcón, Marcel; Uribarri, María; Bailey, Alexis; Herradón, Gonzalo
European Neuropsychopharmacology, 2016 , vol. 26, # 11 p. 1794 - 1805 Title/Abstract Full Text Show Details
dos Santos, Vagner Bezerra; Daniel, Daniela; Singh, Melina; do Lago, Claudimir Lucio
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2016 , vol. 1038, p. 19 - 25 Title/Abstract Full Text Show Details
Gupta, Kunal; Muhammed, Hazif; Fazil; Kamath, Jagadish V.
International Journal of Pharmaceutical Sciences Review and Research, 2016 , vol. 40, # 2 art. no. 26, p. 122 - 125 Title/Abstract Full Text Show Details
Chen, Pai-Shan; Chen, Shu-Hua; Chen, Jung-Hsuan; Haung, Wan-Yun; Liu, Hsin-Tung; Kong, Po-Hsin; Yang, Olivia HsuYuan
Analytica Chimica Acta, 2016 , vol. 946, p. 1 - 8 Title/Abstract Full Text Show Details
Hernaus; Mehta
NeuroImage, 2016 , vol. 142, p. 663 - 667 Title/Abstract Full Text Show Details
Sun, Ying-pei; Ha, Wei; Chen, Juan; Qi, Huan-yang; Shi, Yan-ping
TrAC - Trends in Analytical Chemistry, 2016 , vol. 84, p. 12 - 21 Title/Abstract Full Text Show Details
Putnam-Hornstein, Emily; Prindle, John J.; Leventhal, John M.
Pediatrics, 2016 , vol. 138, # 3 art. no. E20161273 Title/Abstract Full Text Show Details
Bezhentsev, Vladislav M.; Tarasova, Olga A.; Dmitriev, Aleksandr V.; Rudik, Anastasiya V.; Lagunin, Aleksey A.; Filimonov, Dmitriy A.; Poroikov, Vladimir V.
Russian Chemical Reviews, 2016 , vol. 85, # 8 p. 854 - 879 Title/Abstract Full Text Show Details
Xu, Xiaomeng; Ma, Shifan; Feng, Zhiwei; Hu, Guanxing; Wang, Lirong; Xie, Xiang-Qun
Journal of Molecular Graphics and Modelling, 2016 , vol. 70, p. 284 - 295 Title/Abstract Full Text Show Details
Michelis, Joan Philipp; Zimmermann, Julian; Bedarf, Janis Rebecca; Bundschuh, Ralph; Gaertner, Florian C.; Paus
Parkinsonism and Related Disorders, 2016 , vol. 31, p. 153 - 155 Title/Abstract Full Text Show Details
Gauvin, David V.; Zimmermann, Zachary J.; Kallman, Mary Jeanne
Drug and Alcohol Dependence, 2016 , vol. 168, p. 307 - 319 Title/Abstract Full Text Show Details
Hutsell, Blake A.; Negus, S. Stevens; Banks, Matthew L.
Drug and Alcohol Dependence, 2016 , vol. 168, p. 36 - 44 Title/Abstract Full Text Show Details
Gartziandia; Herrán; Ruiz-Ortega; Miguelez; Igartua; Lafuente; Pedraz; Ugedo; Hernández
Journal of Biomedical Nanotechnology, 2016 , vol. 12, # 12 p. 2220 - 2230 Title/Abstract Full Text Show Details
Becker, Jill B.; McClellan, Michele L.; Reed, Beth Glover
Journal of Neuroscience Research, 2017 , vol. 95, # 1-2 p. 136 - 147 Title/Abstract Full Text Show Details
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Comment (Pharmacological Data)
Bioactivities present
Reference
Orsini, Caitlin A.; Setlow, Barry
Journal of Neuroscience Research, 2017 , vol. 95, # 1-2 p. 260 - 269 Title/Abstract Full Text Show Details
Bundgaard, Christoffer; Montezinho, Liliana P.; Anderson, Neil; Thomsen, Christian; Mørk, Arne
Pharmacology Biochemistry and Behavior, 2016 , vol. 150-151, p. 147 - 152 Title/Abstract Full Text Show Details
Wang, Sheng-Min; Han, Changsu; Lee, Soo-Jung; Jun, Tae-Youn; Patkar, Ashwin A.; Masand, Prakash S.; Pae, Chi-Un
Journal of Psychiatric Research, 2017 , vol. 84, p. 292 - 300 Title/Abstract Full Text Show Details
Luhrs, Lauren; Manlapaz, Cynthia; Kedzie, Karen; Rao, Sandhya; Cabrera-Ghayouri, Sara; Donello, John; Gil, Daniel
Neuroscience, 2016 , vol. 339, p. 608 - 621 Title/Abstract Full Text Show Details
Childs, Emma; de Wit, Harriet
Addiction, 2016 , vol. 111, # 12 p. 2157 - 2165 Title/Abstract Full Text Show Details
Moehlecke, Milene; Canani, Luis Henrique; e Silva, Lucas Oliveira Junqueira; Trindade, Manoel Roberto Maciel; Friedman, Rogerio; Leitão, Cristiane Bauermann
Archives of Endocrinology and Metabolism, 2016 , vol. 60, # 2 p. 152 - 162 Title/Abstract Full Text Show Details
Juurmaa, Julius; Menke, Ricarda A. L.; Vila, Pierre; Müürsepp, Andreas; Tomberg, Tiiu; Ilves, Pilvi; Nigul, Mait; JohansenBerg, Heidi; Donaghy, Michael; Stagg, Charlotte J.; Stepens, Ainārs; Taba, Pille
Brain and Behavior, 2016 , vol. 6, # 11 art. no. E00539 Title/Abstract Full Text Show Details
Cheng, Vincent; Inaba, Kenji; Johnson, Megan; Byerly, Saskya; Jiang, Yue; Matsushima, Kazuhide; Haltmeier, Tobias; Benjamin, Elizabeth; Lam, Lydia; Demetriades, Demetrios
Journal of Trauma and Acute Care Surgery, 2016 , vol. 81, # 5 p. 913 - 920 Title/Abstract Full Text Show Details
Saka, Cafer
Critical Reviews in Analytical Chemistry, 2017 , vol. 47, # 1 p. 1 - 23 Title/Abstract Full Text Show Details
White, Tara L.
Current Opinion in Behavioral Sciences, 2017 , vol. 13, p. 63 - 70 Title/Abstract Full Text Show Details
Mack, Josiel Mileno; Schamne, Marissa Giovanna; Sampaio, Tuane Bazanella; Pértile, Renata Aparecida Nedel; Fernandes, Pedro Augusto Carlos Magno; Markus, Regina P.; Prediger, Rui Daniel
Oxidative Medicine and Cellular Longevity, 2016 , vol. 2016, art. no. 3472032 Title/Abstract Full Text Show Details
Shen, Erica Y.; Jiang, Yan; Javidfar, Behnam; Kassim, Bibi; Loh, Yong-Hwee E.; Ma, Qi; Mitchell, Amanda C.; Pothula, Venu; Stewart, A Francis; Ernst, Patricia; Yao, Wei-Dong; Martin, Gilles; Shen, Li; Jakovcevski, Mira; Akbarian, Schahram
Neuropsychopharmacology, 2016 , vol. 41, # 13 p. 3103 - 3113 Title/Abstract Full Text Show Details
Barkus, Chris; Korn, Clio; Stumpenhorst, Katharina; Laatikainen, Linda M.; Ballard, Dominic; Lee, Sheena; Sharp, Trevor; Harrison, Paul J.; Bannerman, David M.; Weinberger, Daniel R.; Chen, Jingshan; Tunbridge, Elizabeth M.
Neuropsychopharmacology, 2016 , vol. 41, # 13 p. 3060 - 3069 Title/Abstract Full Text Show Details
Boileau, Isabelle; Payer, Doris; Rusjan, Pablo M.; Houle, Sylvain; Tong, Junchao; McCluskey, Tina; Wilson, Alan A.; Kish, Stephen J.
Neuropsychopharmacology, 2016 , vol. 41, # 13 p. 2994 - 3002 Title/Abstract Full Text Show Details
Bora, Feyza; Yılmaz, Fatih; Bora, Taner
Iranian Journal of Basic Medical Sciences, 2016 , vol. 19, # 11 p. 1151 - 1158 Title/Abstract Full Text Show Details
Clasen, Matthew M.; Wetzell, Bradley B.; Riley, Anthony L.
Learning and Behavior, 2016 , vol. 44, # 4 p. 356 - 365 Title/Abstract Full Text Show Details
Abourashed, Ehab A.; El-Alfy, Abir T.
Phytochemistry Reviews, 2016 , vol. 15, # 6 p. 1035 - 1056 Title/Abstract Full Text Show Details
Abad; Camarasa; Pubill; Camins; Escubedo
Molecular Neurobiology, 2016 , vol. 53, # 10 p. 7271 - 7283 Title/Abstract Full Text Show Details
Zack, Martin; Cho, Sang Soo; Parlee, Jennifer; Jacobs, Mark; Li, Crystal; Boileau, Isabelle; Strafella, Antonio
Brain Stimulation, 2016 , vol. 9, # 6 p. 867 - 875 Title/Abstract Full Text Show Details
MacLaren, Duncan A. A.; Browne, Richard W.; Shaw, Jessica K.; Radhakrishnan, Sandhya Krishnan; Khare, Prachi; España, Rodrigo A.; Clark, Stewart D.
eNeuro, 2016 , vol. 3, # 5 art. no. E0219-16.2016 Title/Abstract Full Text Show Details
Comment (Pharmacological Data)
Bioactivities present
Reference
Robbins
Journal of Psychopharmacology, 2016 , vol. 30, # 11 p. 1082 - 1089
Title/Abstract Full Text Show Details
Pintsuk, Julia; Borroto-Escuela, Dasiel O.; Lai, Terence K.Y.; Liu, Fang; Fuxe, Kjell
Life Sciences, 2016 , vol. 167, p. 92 - 97 Title/Abstract Full Text Show Details
Beaulieu, Jean-Martin
Journal of Neurochemistry, 2016 , vol. 139, # 4 p. 520 - 522 Title/Abstract Full Text Show Details
Can, Adem; Frost, Douglas O.; Cachope, Roger; Cheer, Joseph F.; Gould, Todd D.
Journal of Neurochemistry, 2016 , vol. 139, # 4 p. 576 - 585 Title/Abstract Full Text Show Details
Betzler; Heinz; Köhler
Fortschritte der Neurologie Psychiatrie, 2016 , vol. 84, # 11 p. 690 - 698 Title/Abstract Full Text Show Details
Berning, Moritz; Hardon, Anita
Contemporary Drug Problems, 2016 , vol. 43, # 3 p. 277 - 292 Title/Abstract Full Text Show Details
Hupli, Aleksi; Didžiokaitė, Gabija; Ydema, Marte
Contemporary Drug Problems, 2016 , vol. 43, # 3 p. 242 - 257 Title/Abstract Full Text Show Details
Mandler, Tait
Contemporary Drug Problems, 2016 , vol. 43, # 3 p. 258 - 276 Title/Abstract Full Text Show Details
Le Garff, Erwan; Tournel, Gilles; Becquart, Coralie; Cottencin, Olivier; Dupin, Nicolas; Delaporte, Emmanuel; Hedouin, Valéry
Journal of Forensic Sciences, 2016 , vol. 61, # 6 p. 1681 - 1685 Title/Abstract Full Text Show Details
Gururajan, Anand; Malone, Daniel Thomas
Schizophrenia Research, 2016 , vol. 176, # 2-3 p. 281 - 290 Title/Abstract Full Text Show Details
Egerton, Alice; Valmaggia, Lucia R.; Howes, Oliver D.; Day, Fern; Chaddock, Christopher A.; Allen, Paul; Winton-Brown, Toby T.; Bloomfield, Michael A.P.; Bhattacharyya, Sagnik; Chilcott, Jack; Lappin, Julia M.; Murray, Robin M.; McGuire, Philip
Schizophrenia Research, 2016 , vol. 176, # 2-3 p. 171 - 176 Title/Abstract Full Text Show Details
Bluth, Martin H.; Pincus, Matthew R.
Clinics in Laboratory Medicine, 2016 , vol. 36, # 4 p. 603 - 634 Title/Abstract Full Text Show Details
Alcamán, Katherinne; Duffau, Boris Ettienne; Morales, Daniela
Journal of Planar Chromatography - Modern TLC, 2016 , vol. 29, # 6 p. 474 - 476 Title/Abstract Full Text Show Details
Jansone, Baiba; Kuum, Malle; Maciulaitis, Romaldas
Pharmacological Research, 2016 , vol. 113, p. 721 - 722 Title/Abstract Full Text Show Details
Zhang, Yan Victoria; Wei, Bin; Zhu, Yu; Zhang, Yanhua; Bluth, Martin H.
Clinics in Laboratory Medicine, 2016 , vol. 36, # 4 p. 635 - 661 Title/Abstract Full Text Show Details
Motaghinejad, Majid; Motevalian, Manijeh; Falak, Reza; Heidari, Mansour; Sharzad, Mahshid; Kalantari, Elham
Journal of Neural Transmission, 2016 , vol. 123, # 12 p. 1463 - 1477 Title/Abstract Full Text Show Details
Krishnan, Archana; Brown, Shan-Estelle; Ghani, Mansur A.; Khan, Farrah; Kamarulzaman, Adeeba; Altice, Frederick L.
Substance Abuse, 2016 , vol. 37, # 4 p. 542 - 549 Title/Abstract Full Text Show Details
Karlstad, Øystein; Zoëga, Helga; Furu, Kari; Bahmanyar, Shahram; Martikainen, Jaana E; Kieler, Helle; Pottegård, Anton
European Journal of Clinical Pharmacology, 2016 , vol. 72, # 12 p. 1507 - 1514 Title/Abstract Full Text Show Details
Li, Peng; Snyder, Gretchen L.; Vanover, Kimberly E.
Current Topics in Medicinal Chemistry, 2016 , vol. 16, # 29 p. 3385 - 3403 Title/Abstract Full Text Show Details
Sharma, Kanchan; Davis, Thomas; Coulthard, Elizabeth
Translational Neuroscience, 2016 , vol. 7, # 1 p. 98 - 109 Title/Abstract Full Text Show Details
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Comment (Pharmacological Data)
Bioactivities present
Reference
Storholm, Erik David; Silverberg, Michael J.; Satre, Derek D.
Journal of Psychoactive Drugs, 2016 , vol. 48, # 5 p. 377 - 383 Title/Abstract Full Text Show Details
Shimomura, Eric T.; Briones, Alice J.; Warren, Wendy S.; Addison, Joseph W.; Knittel, Jessica L.; Shoemaker, Sarah A.; King, Taj D.; Bosy, Thomas Z.
Journal of Analytical Toxicology, 2016 , vol. 40, # 7 art. no. BKW045, p. 543 - 545 Title/Abstract Full Text Show Details
Busardò, Francesco P.; Pichini, Simona; Pacifici, Roberta; Karch, Steven B.
Journal of Analytical Toxicology, 2016 , vol. 40, # 7 art. no. BKW051, p. 561 - 562 Title/Abstract Full Text Show Details
Casolin, Armand
Journal of Analytical Toxicology, 2016 , vol. 40, # 7 art. no. BKW055, p. 479 - 485 Title/Abstract Full Text Show Details
Bakota, Erica; Arndt, Crystal; Romoser, Amelia A.; Wilson, Stephen K.
Journal of Analytical Toxicology, 2016 , vol. 40, # 7 art. no. BKW056, p. 504 - 510 Title/Abstract Full Text Show Details
Jamey, Carole; Kintz, Pascal; Martrille, Laurent; Raul, Jean-Sébastien
Journal of Analytical Toxicology, 2016 , vol. 40, # 7 art. no. BKW058, p. 546 - 552 Title/Abstract Full Text Show Details
Skov, Louise; Holm, Karen Marie Dollerup; Johansen, Sys Stybe; Linnet, Kristian
Journal of Analytical Toxicology, 2016 , vol. 40, # 7 art. no. BKW059, p. 529 - 536
Title/Abstract Full Text Show Details
Nieddu, Maria; Burrai, Lucia; Baralla, Elena; Pasciu, Valeria; Varoni, Maria Vittoria; Briguglio, Irene; Demontis, Maria Piera; Boatto, Gianpiero
Journal of Analytical Toxicology, 2016 , vol. 40, # 7 art. no. BKW060, p. 492 - 497 Title/Abstract Full Text Show Details
Smith; Cole; Hamilton; West; Morley; Maskell
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Bhatt, Meha; Zielinski, Laura; Baker-Beal, Lola; Bhatnagar, Neera; Mouravska, Natalia; Laplante, Phillip; Worster, Andrew; Thabane, Lehana; Samaan, Zainab
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BMJ Open, 2016 , vol. 6, # 11 art. no. E011891 Title/Abstract Full Text Show Details
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International Journal of Clinical Dentistry, 2016 , vol. 9, # 3 p. 205 - 212 Title/Abstract Full Text Show Details
Shahani, Neelam; Swarnkar, Supriya; Giovinazzo, Vincenzo; Morgenweck, Jenny; Bohn, Laura M.; Scharager-Tapia, Catherina; Pascal, Bruce; Martinez-Acedo, Pablo; Khare, Kshitij; Subramaniam, Srinivasa
Science Signaling, 2016 , vol. 9, # 454 art. no. RA111 Title/Abstract Full Text Show Details
Konieczny, Jolanta; Czarnecka, Anna; Lenda, Tomasz; Kamińska, Kinga; Antkiewicz-Michaluk, Lucyna
Neuroscience, 2017 , vol. 340, p. 308 - 318 Title/Abstract Full Text Show Details
Bloomfield, Michael A. P.; Ashok, Abhishekh H.; Volkow, Nora D.; Howes, Oliver D.
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Colby, Donn; Nguyen, Ngoc Anh; Le, Bao; Toan, Trang; Thien, Dinh Duc; Huyen, Hoang Thi; Mai, Thi Doan Anh; Friedman, Mackey R.; Stall, Ron
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UNIVERSITY OF KANSAS; UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.; GOLDEN, Jennifer E.; CHUNG, Donghoon
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Paul, Michael J.; Chisolm, Margaret S.; Johnson, Matthew W.; Vandrey, Ryan G.; Dredze, Mark
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Comment (Pharmacological Data)
Bioactivities present
Reference
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ACS Chemical Neuroscience, 2016 , vol. 7, # 11 p. 1508 - 1518 Title/Abstract Full Text Show Details
Vonder Haar, Cole; Lam, Frederick C.W.; Adams, Wendy K.; Riparip, Lara-Kirstie; Kaur, Sukhbir; Muthukrishna, Michael; Rosi, Susanna; Winstanley, Catharine A.
ACS Chemical Neuroscience, 2016 , vol. 7, # 11 p. 1531 - 1542 Title/Abstract Full Text Show Details
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Adverse Drug Reaction Bulletin, 2016 , vol. 299, # 1 p. 1155 - 1158 Title/Abstract Full Text Show Details
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Journal of Substance Abuse Treatment, 2017 , vol. 73, p. 55 - 62 Title/Abstract Full Text Show Details
Berihu, Birhane Alem; Asfeha, Gebrekidan Gebregzabher; Welderufael, Abadi L.; Debeb, Yared Godefa; Zelelow, Yibrah Berhe; Beyene, Hafte Assefa
Journal of Neurosciences in Rural Practice, 2017 , vol. 8, # 1 p. 30 - 37 Title/Abstract Full Text Show Details
Todd, Gabrielle; Pearson-Dennett, Verity; Wilcox, Robert A.; Chau, Minh T.; Thoirs, Kerry; Thewlis, Dominic; Vogel, Adam P.; White, Jason M.
Parkinsonism and Related Disorders, 2016 , vol. 25, p. 27 - 32 Title/Abstract Full Text Show Details
Muceniece, Ruta; Namniece, Jana; Nakurte, Ilva; Jekabsons, Kaspars; Riekstina, Una; Jansone, Baiba
Pharmacological Research, 2016 , vol. 113, p. 760 - 770 Title/Abstract Full Text Show Details
O'Leary, Aet; Kõiv, Kadri; Raudkivi, Karita; Harro, Jaanus
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Frontiers in Neuroendocrinology, 2016 , vol. 43, p. 1 - 18 Title/Abstract Full Text Show Details
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European Journal of Medicinal Chemistry, 2017 , vol. 125, p. 210 - 224
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Maia, Tiago V.; Frank, Michael J.
Biological Psychiatry, 2017 , vol. 81, # 1 p. 52 - 66 Title/Abstract Full Text Show Details
Chuhma, Nao; Mingote, Susana; Kalmbach, Abigail; Yetnikoff, Leora; Rayport, Stephen
Biological Psychiatry, 2017 , vol. 81, # 1 p. 43 - 51 Title/Abstract Full Text Show Details
Howes, Oliver D.; McCutcheon, Robert; Owen, Michael J.; Murray, Robin M.
Biological Psychiatry, 2017 , vol. 81, # 1 p. 9 - 20 Title/Abstract Full Text Show Details
Urs, Nikhil M.; Peterson, Sean M.; Caron, Marc G.
Biological Psychiatry, 2017 , vol. 81, # 1 p. 78 - 85 Title/Abstract Full Text Show Details
Schmidt, Thomas P.; Pennington, David L.; Cardoos, Stephanie L.; Durazzo, Timothy C.; Meyerhoff, Dieter J.
Journal of Clinical and Experimental Neuropsychology, 2017 , vol. 39, # 1 p. 22 - 34 Title/Abstract Full Text Show Details
Vahabzadeh, Maryam; Toussi, Alireza Ghassemi
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Pineo, Caleb Evans; Pineo, Thomas Zeitler
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CUREMARK, LLC; Fallon, Joan M.; Heil, Matthew; Szigethy, James; Fallon, James
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Comment (Pharmacological Data)
Bioactivities present
Reference
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Neuropharmacology, 2017 , vol. 114, p. 48 - 57 Title/Abstract Full Text Show Details
Beheshti, Siamak; Zeinali, Reyhaneh; Esmaeili, Abolghasem
Behavioural Brain Research, 2017 , vol. 320, p. 85 - 90 Title/Abstract Full Text Show Details
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Science of the Total Environment, 2016 , vol. 573, p. 1648 - 1659 Title/Abstract Full Text Show Details
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Addictive Behaviors, 2017 , vol. 65, p. 242 - 244 Title/Abstract Full Text Show Details
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Ecotoxicology and Environmental Safety, 2017 , vol. 137, p. 113 - 120 Title/Abstract Full Text Show Details
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Forensic Science International, 2017 , vol. 270, p. 111 - 120 Title/Abstract Full Text Show Details
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Current Opinion in Behavioral Sciences, 2017 , vol. 13, p. 130 - 138 Title/Abstract Full Text Show Details
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Journal of Psychopharmacology, 2016 , vol. 30, # 12 p. 1230 - 1247 Title/Abstract Full Text Show Details
Bershad, Anya K.; Miller, Melissa A.; Baggott, Matthew J.; De Wit, Harriet
Journal of Psychopharmacology, 2016 , vol. 30, # 12 p. 1248 - 1258 Title/Abstract Full Text Show Details
Schänzer, Wilhelm; Thevis, Mario
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Neurobiology of Disease, 2017 , vol. 97, p. 189 - 200 Title/Abstract Full Text Show Details
Palamar, Joseph J.; Acosta, Patricia; Ompad, Danielle C.; Cleland, Charles M.
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Comment (Pharmacological Data)
Bioactivities present
Reference
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Neuroscience Letters, 2017 , vol. 638, p. 21 - 26 Title/Abstract Full Text Show Details
Magni, Stefano; Parolini, Marco; Della Torre, Camilla; de Oliveira, Luciana Fernandes; Catani, Martina; Guzzinati, Roberta; Cavazzini, Alberto; Binelli, Andrea
Science of the Total Environment, 2017 , vol. 578, p. 452 - 459 Title/Abstract Full Text Show Details
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Experimental and Clinical Psychopharmacology, 2016 , vol. 24, # 6 p. 464 - 476 Title/Abstract Full Text Show Details
Letourneau, Elizabeth J.; McCart, Michael R.; Sheidow, Ashli J.; Mauro, Pia M.
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Mascolo; Sessa; Scavone; De Angelis; Vitale; Berrino; Rossi; Rosano; Capuano
International Journal of Cardiology, 2017 , vol. 227, p. 734 - 742 Title/Abstract Full Text Show Details
Tarján, Anna; Dudás, Mária; Wiessing, Lucas; Horváth, Gergely; Rusvai, Erzsébet; Tresó, Bálint; Csohán, Ágnes
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Alharbi, Fares F.; El-Guebaly, Nady
Addictive Disorders and their Treatment, 2016 , vol. 15, # 4 p. 190 - 200 Title/Abstract Full Text Show Details
Garcia, Erik J.; Jorgensen, Emily T.; Sprick, Lukas S.; Cain, Mary E.
Behavioural Brain Research, 2017 , vol. 320, p. 186 - 194 Title/Abstract Full Text Show Details
Urs, Nikhil M.; Gee, Steven M.; Pack, Thomas F.; McCorvy, John D.; Evron, Tama; Snyder, Joshua C.; Yang, Xiaobao; Rodriguiz, Ramona M.; Borrelli, Emiliana; Wetsel, William C.; Jin, Jian; Roth, Bryan L.; O'Donnell, Patricio; Caron, Marc G.; Snyder, Solomon H.
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Slifstein, Mark; Abi-Dargham, Anissa
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RUGEN HOLDINGS (CAYMAN) LIMITED; SHAPIRO, Gideon
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Anniss, Angela M.; Young, Alan; O'Driscoll, Denise M.
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Comment (Pharmacological
Bioactivities present
Data)
82 of 317
Reference
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Van De Giessen; Weinstein; Cassidy; Haney; Dong; Ghazzaoui; Ojeil; Kegeles; Xu; Vadhan; Volkow; Slifstein; Abi-Dargham
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Chemosphere, 2017 , vol. 168, p. 1032 - 1041 Title/Abstract Full Text Show Details
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Cunha; Lopes; Fernandes
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Mereu, Maddalena; Chun, Lauren E.; Prisinzano, Thomas E.; Newman, Amy H.; Katz, Jonathan L.; Tanda, Gianluigi
European Journal of Neuroscience, 2017 , vol. 45, # 1 p. 167 - 174 Title/Abstract Full Text Show Details
Comment (Pharmacological Data)
Bioactivities present
Reference
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European Journal of Neuroscience, 2017 , vol. 45, # 1 p. 2 - 19 Title/Abstract Full Text Show Details
Smith, Douglas A.; Blough, Bruce E.; Banks, Matthew L.
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Psychopharmacology, 2017 , vol. 234, # 1 p. 137 - 153 Title/Abstract Full Text Show Details
Best, Laura M.; Zhao, Leah L.; Scardochio, Tina; Clarke, Paul B.S.
Psychopharmacology, 2017 , vol. 234, # 1 p. 155 - 165 Title/Abstract Full Text Show Details
Benn, Abigail; Robinson, Emma S. J.
Psychopharmacology, 2017 , vol. 234, # 2 p. 255 - 266 Title/Abstract Full Text Show Details
Sauerzopf, Ulrich; Sacco, Roberto; Novarino, Gaia; Niello, Marco; Weidenauer, Ana; Praschak-Rieder, Nicole; Sitte, Harald; Willeit, Matthäus
European Journal of Neuroscience, 2017 , vol. 45, # 1 p. 45 - 57 Title/Abstract Full Text Show Details
Leventhal, Adam M.; Kirkpatrick, Matthew G.; Pester, Mollie S.; McGeary, John E.; Swift, Robert M.; Sussman, Steve; Kahler, Christopher W.
Psychopharmacology, 2017 , vol. 234, # 2 p. 307 - 315 Title/Abstract Full Text Show Details
Lohr, Kelly M.; Masoud, Shababa T.; Salahpour, Ali; Miller, Gary W.
European Journal of Neuroscience, 2017 , vol. 45, # 1 p. 20 - 33 Title/Abstract Full Text Show Details
Rise, Jostein; Halkjelsvik, Torleif; Kovač, Velibor Bobo
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Batt, Angela L.; Furlong, Edward T.; Mash, Heath E.; Glassmeyer, Susan T.; Kolpin, Dana W.
Science of the Total Environment, 2017 , vol. 579, p. 1618 - 1628 Title/Abstract Full Text Show Details
Pastor, Verónica; Antonelli, Marta Cristina; Pallarés, María Eugenia
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Rognli, Eline Borger; Bramness, Jørgen G.; Skurtveit, Svetlana; Bukten, Anne
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Budzynska, Barbara; Michalak, Agnieszka; Frankowska, Małgorzata; Kaszubska, Katarzyna; Biała, Grażyna
Pharmacological Reports, 2017 , vol. 69, # 2 p. 199 - 205 Title/Abstract Full Text Show Details
Prendergast, Michael L.; McCollister, Kathryn; Warda, Umme
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Bahmanabadi; Akhgari; Jokar; Sadeghi
Human and Experimental Toxicology, 2017 , vol. 36, # 2 p. 195 - 202 Title/Abstract Full Text Show Details
Vicente-Rodríguez, Marta; Fernández-Calle, Rosalía; Gramage, Esther; Pérez-García, Carmen; Ramos, María P.; Herradón, Gonzalo
Mediators of Inflammation, 2016 , vol. 2016, art. no. 9894504 Title/Abstract Full Text Show Details
Mattingly, Gregory W.; Anderson, Richard H.
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Kim, Minjeong; Kim, Da Hye; Lee, Yong Sup; Jang, Choon-Gon; Yang, Chae Ha; Lee, Sooyeun
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Comment (Pharmacological Data)
Bioactivities present
Reference
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Kuś, Piotr; Kusz, Joachim; Książek, Maria; Pieprzyca, Ewelina; Rojkiewicz, Marcin
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Taschwer, Magdalena; Grascher, Jörg; Schmid, Martin G.
Forensic Science International, 2017 , vol. 270, p. 232 - 240 Title/Abstract Full Text Show Details
Tung, Che-Se; Chang, Shang-Tang; Huang, Chuen-Lin; Huang, Nai-Kuei
Neuroscience Letters, 2017 , vol. 639, p. 185 - 191 Title/Abstract Full Text Show Details
Doran, Gregory S.; Deans, Ralph M.; De Filippis, Carlo; Kostakis, Chris; Howitt, Julia A.
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Jafari Giv, Mahsa
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Nesbit, Maya O.; Dias, Carine; Phillips, Anthony G.
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Mardal, Marie; Kinyua, Juliet; Ramin, Pedram; Miserez, Bram; Van Nuijs, Alexander L. N.; Covaci, Adrian; Meyer, Markus R.
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Bordin, Dayanne Mozaner; Bettim, Bárbara Beltrame; Perdona, Gleici Castro; de Campos, Eduardo Geraldo; De Martinis, Bruno Spinosa
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Lendoiro, Elena; Jiménez-Morigosa, Cristian; Cruz, Angelines; Páramo, Mario; López-Rivadulla, Manuel; de Castro, Ana
Drug Testing and Analysis, 2017 , vol. 9, # 1 p. 96 - 105 Title/Abstract Full Text Show Details
Jakova, Elisabet; Lee, Jeremy S.
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Zhang, Qian; Yang, Feng-Qing; Ge, Liya; Hu, Yuan-Jia; Xia, Zhi-Ning
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Sánchez-Catalán, María-José; Faivre, Fanny; Yalcin, Ipek; Muller, Marc-Antoine; Massotte, Dominique; Majchrzak, Monique; Barrot, Michel
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Chengdu Chester Technology Co., Ltd.; Peng, Fei
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Canal, Clinton E.; Murnane, Kevin S.
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Comment (Pharmacological Data)
Bioactivities present
Reference
Zack, Martin H.; Lobo, Daniela S.; Biback, Candice; Fang, Tim; Smart, Kelly; Tatone, Daniel; Kalia, Aditi; Digiacomo, Daniel; Kennedy, James L.
Journal of Psychopharmacology, 2017 , vol. 31, # 1 p. 31 - 42 Title/Abstract Full Text Show Details
Mahmud, Ashraf; Gallant, Stephanie; Sedki, Firas; D'Cunha, Tracey; Shalev, Uri
Journal of Psychopharmacology, 2017 , vol. 31, # 1 p. 96 - 104 Title/Abstract Full Text Show Details
Lehner, Małgorzata H.; Taracha, Ewa; Kaniuga, Ewelina; Wisłowska-Stanek, Aleksandra; Gryz, Marek; Sobolewska, Alicja; Turzyńska, Danuta; Skórzewska, Anna; PłaŁnik, Adam
Journal of Psychopharmacology, 2017 , vol. 31, # 1 p. 115 - 126 Title/Abstract Full Text Show Details
Yates, Justin R.; Rogers, Katherine K.; Gunkel, Benjamin T.; Prior, Nicholas A.; Hughes, Mallory N.; Sharpe, Sara M.; Campbell, Hunter L.; Johnson, Anthony B.; Keller, Margaret G.; Breitenstein, Kerry A.; Shults, Hansen N.
Behavioural Brain Research, 2017 , vol. 322, p. 29 - 33 Title/Abstract Full Text Show Details
Gremel; Lovinger
Genes, Brain and Behavior, 2017 , vol. 16, # 1 p. 71 - 85 Title/Abstract Full Text Show Details
Gillies, Glenda E.; Virdee, Kanwar; Pienaar, Ilse; Al-Zaid, Felwah; Dalley, Jeffrey W.
Brain Sciences, 2017 , vol. 7, # 1 art. no. 5 Title/Abstract Full Text Show Details
Ardani, Amir Rezaei; Saghebi, Seyyed Ali; Nahidi, Mahsa; Zeynalian, Farzaneh
Sleep Science, 2016 , vol. 9, # 3 p. 255 - 260 Title/Abstract Full Text Show Details
Fischbach, Peter
Cardiology in the Young, 2017 , vol. 27, # S1 p. S75 - S79 Title/Abstract Full Text Show Details
Østergaard, Jeanette; Østergaard, Stine V.; Fletcher, Adam
Contemporary Drug Problems, 2016 , vol. 43, # 4 p. 350 - 368 Title/Abstract Full Text Show Details
Tormoehlen, Laura M.; Blatsioris, Ashley D.; Moser, Elizabeth A.S.; Carter, Ravan J.L.; Stevenson, Alec; Ofner, Susan; Hulin, Abigail L.; O'Neill, Darren P.; Cohen-Gadol, Aaron A.; Leipzig, Thomas J.; Williams, Linda S.; Mackey, Jason
Neurology, 2017 , vol. 88, # 3 p. 252 - 258 Title/Abstract Full Text Show Details
Jørgensen, Louise M.; Weikop, Pia; Villadsen, Jonas; Visnapuu, Tanel; Ettrup, Anders; Hansen, Hanne D; Baandrup, Anders O; Andersen, Flemming L; Bjarkam, Carsten R; Thomsen, Carsten; Jespersen, Bo; Knudsen, Gitte M.
Journal of Cerebral Blood Flow and Metabolism, 2016 , vol. 37, # 2 p. 425 - 434 Title/Abstract Full Text Show Details
Momosaki, Sotaro; Ito, Miwa; Yamato, Hiroko; Iimori, Hitoshi; Sumiyoshi, Hirokazu; Morimoto, Kenji; Imamoto, Natsumi; Watabe, Tadashi; Shimosegawa, Eku; Hatazawa, Jun; Abe, Kohji
Journal of Cerebral Blood Flow and Metabolism, 2016 , vol. 37, # 2 p. 605 - 613 Title/Abstract Full Text Show Details
Motaghinejad, Majid; Motevalian, Manijeh; Shabab, Behnaz; Fatima, Sulail
Journal of Neural Transmission, 2017 , vol. 124, # 1 p. 121 - 131 Title/Abstract Full Text Show Details
Riederer, Peter; Müller, Thomas
Expert Opinion on Drug Metabolism and Toxicology, 2017 , vol. 13, # 2 p. 233 - 240 Title/Abstract Full Text Show Details
Almey, Anne; Arena, Lauren; Oliel, Joshua; Hafez, Nada; Mancinelli, Cynthia; Henning, Lukas; Tsanev, Aleks; Brake, Wayne G.
Hormones and Behavior, 2017 , vol. 89, p. 113 - 120 Title/Abstract Full Text Show Details
Garasic, Mirko D.; Lavazza, Andrea
BMC Medical Ethics, 2016 , vol. 17, # 1 art. no. 01601028 Title/Abstract Full Text Show Details
Philippu, Athineos
Current Medicinal Chemistry, 2016 , vol. 23, # 28 p. 2643 - 2652 Title/Abstract Full Text Show Details
Phillips, Ian R.; Shephard, Elizabeth A.
Expert Opinion on Drug Metabolism and Toxicology, 2017 , vol. 13, # 2 p. 167 - 181 Title/Abstract Full Text Show Details
Price, James W.
Journal of Addiction Medicine, 2016 , vol. 10, # 6 p. 414 - 417 Title/Abstract Full Text Show Details
Bajaj, Atul; John, Cijo; Kaur, Sukhminder; Middha, Deepak
Egyptian Journal of Forensic Sciences, 2016 , vol. 6, # 4 p. 538 - 541 Title/Abstract Full Text Show Details
85 of 317
Comment (Pharmacological Data)
Bioactivities present
Reference
Garcia, Erik J.; Haddon, Tara N.; Saucier, Donald A.; Cain, Mary E.
Pharmacology Biochemistry and Behavior, 2017 , vol. 154, p. 20 - 30 Title/Abstract Full Text Show Details
Nakagawa, Yoshio; Suzuki, Toshinari; Tada, Yukie; Inomata, Akiko
Journal of Applied Toxicology, 2017 , vol. 37, # 3 p. 243 - 252 Title/Abstract Full Text Show Details
Köhler, Katharina M.; Hammer, Raija; Riedy, Kathrin; Auwärter, Volker; Neukamm, Merja A.
Journal of Clinical Laboratory Analysis, 2017 , vol. 31, # 1 art. no. E22021 Title/Abstract Full Text Show Details
Morana, Landhing M.; Phillipsa, Karran A.; Kowalczyka, William J.; Ghitzab, Udi E.; Agagea, Daniel A.; Epsteina, David H.; Prestona, Kenzie L.
Behavioural Pharmacology, 2017 , vol. 28, # 1 p. 63 - 73 Title/Abstract Full Text Show Details
Hädener, Marianne; Bruni, Pia S.; Weinmann, Wolfgang; Frübis, Matthias; König, Stefan
Analytical and Bioanalytical Chemistry, 2017 , vol. 409, # 5 p. 1291 - 1300 Title/Abstract Full Text Show Details
Narayanaswami, Vidya; Dwoskin, Linda P.
Pharmacology and Therapeutics, 2017 , vol. 170, p. 116 - 147 Title/Abstract Full Text Show Details
Alshagga, Mustafa Ahmed; Alshawsh, Mohammed Abdullah; Seyedan, Atefehalsadat; Alsalahi, Abdulsamad; Pan, Yan; Mohankumar, Suresh Kumar; Alkebsi, Abdolgodose; Kassim, Saba; Mohamed, Zahurin
Annals of Nutrition and Metabolism, 2017 , vol. 69, # 3-4 p. 200 - 211 Title/Abstract Full Text Show Details
Andra, Syam S.; Austin, Christine; Patel, Dhavalkumar; Dolios, Georgia; Awawda, Mahmoud; Arora, Manish
Environment International, 2017 , vol. 100, p. 32 - 61 Title/Abstract Full Text Show Details
Roberts, Liam; Ford, Loretta; Patel, Neel; Vale, J. Allister; Bradberry, Sally M.
Clinical Toxicology, 2017 , vol. 55, # 3 p. 181 - 186 Title/Abstract Full Text Show Details
Todd, Stephanie M.; Zhou, Cilla; Clarke, David J.; Chohan, Tariq W.; Bahceci, Dilara; Arnold, Jonathon C.
European Neuropsychopharmacology, 2017 , vol. 27, # 2 p. 132 - 145 Title/Abstract Full Text Show Details
Gracia-Lor, Emma; Castiglioni, Sara; Bade, Richard; Been, Frederic; Castrignanò, Erika; Covaci, Adrian; González-Mariño, Iria; Hapeshi, Evroula; Kasprzyk-Hordern, Barbara; Kinyua, Juliet; Lai, Foon Yin; Letzel, Thomas; Lopardo, Luigi; Meyer, Markus R.; O'Brien, Jake; Ramin, Pedram; Rousis, Nikolaos I.; Rydevik, Axel; Ryu, Yeonsuk; Santos, Miguel M.; Senta, Ivan; Thomaidis, Nikolaos S.; Veloutsou, Sofia; Yang, Zhugen; Zuccato, Ettore; Bijlsma, Lubertus
Environment International, 2017 , vol. 99, p. 131 - 150 Title/Abstract Full Text Show Details
Mowry, James B.; Spyker, Daniel A.; Brooks, Daniel E.; Zimmerman, Ashlea; Schauben, Jay L.
Clinical Toxicology, 2016 , vol. 54, # 10 p. 924 - 1109 Title/Abstract Full Text Show Details
Spiros, Athan; Roberts, Patrick; Geerts, Hugo
European Neuropsychopharmacology, 2017 , vol. 27, # 2 p. 107 - 119 Title/Abstract Full Text Show Details
Waddell; Fernandez; Inverarity; Prabhu
Sensing and Bio-Sensing Research, 2017 , vol. 13, p. 28 - 39 Title/Abstract Full Text Show Details
Gogos, Andrea; Kusljic, Snezana; Thwaites, Shane J.; van den Buuse, Maarten
Behavioural Brain Research, 2017 , vol. 322, p. 157 - 166 Title/Abstract Full Text Show Details
Müller, Thomas
Expert Opinion on Investigational Drugs, 2017 , vol. 26, # 2 p. 175 - 185 Title/Abstract Full Text Show Details
Verwey, Michael; Dhir, Sabine; Amir, Shimon
F1000Research, 2016 , vol. 5, art. no. 2062 Title/Abstract Full Text Show Details
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.; UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL – UFRGS; UNIVERSIDADE DE SÃO PAULO - USP; MECHOULAM, Raphael; BREUER, Aviva; PEREIRA KAPCZINSKI, Flavio; DE SOUZA CRIPPA, Jose Alexandre; ZUARDI, Antonio Waldo; CECILIO HALLAK, Jaime Eduardo; SILVEIRA GUIMARAES, Francisco
Patent: WO2017/8136 A2, 2017 ;
Title/Abstract Full Text Show Details
Brunt, Tibor M.; Nagy, Constanze; Bücheli, Alexander; Martins, Daniel; Ugarte, Miren; Beduwe, Cécile; Ventura Vilamala, Mireia
Drug Testing and Analysis, 2017 , vol. 9, # 2 p. 188 - 198 Title/Abstract Full Text Show Details
Brandish, Emma K.; Owen, Christopher T.; Sinclair, Julia M.A.
Medicine (United Kingdom), 2017 , vol. 45, # 2 p. 68 - 73 Title/Abstract Full Text Show Details
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Comment (Pharmacological Data)
Bioactivities present
Reference
Petrie, Bruce; Smith, Benjamin D.; Youdan, Jane; Barden, Ruth; Kasprzyk-Hordern, Barbara
Analytica Chimica Acta, 2017 , vol. 959, p. 91 - 101 Title/Abstract Full Text Show Details
Patel, Mayur M.; Patel, Bhoomika M.
CNS Drugs, 2017 , vol. 31, # 2 p. 109 - 133 Title/Abstract Full Text Show Details
Amirav, Aviv
Chromatographia, 2017 , vol. 80, # 2 p. 295 - 300 Title/Abstract Full Text Show Details
Lambert, Mads Ødum; Ipsen, Theis Højland; Kohlmeier, Kristi Anne
Pharmacology Research and Perspectives, 2017 , vol. 5, # 1 art. no. E00282 Title/Abstract Full Text Show Details
Stokes, Robert J.; Bailey, Mike; Bonthron, Stuart; Stone, Thomas; Maskall, Guy; Presly, Oliver; Roy, Eric; Tombling, Craig; Loeffen, Paul W.
Proceedings of SPIE - The International Society for Optical Engineering, 2016 , vol. 9995, art. no. 999506 Title/Abstract Full Text Show Details
Mahmood, Danish
International Journal of Health Science, 2016 , vol. 10, # 4 p. 565 - 575 Title/Abstract Full Text Show Details
Yao, Hui; Rayburn, Elizabeth R.; Shi, Qiang; Gao, Liang; Hu, Wenjie; Li, Haibo
Critical Reviews in Clinical Laboratory Sciences, 2017 , vol. 54, # 1 p. 1 - 17 Title/Abstract Full Text Show Details
Krentz; Fujioka; Hompesch
Diabetes, Obesity and Metabolism, 2016 , vol. 18, # 6 p. 558 - 570 Title/Abstract Full Text Show Details
Meyers, Juliana; Gajria, Kavita; Candrilli, Sean D.; Fridman, Moshe; Sikirica, Vanja
Journal of Comparative Effectiveness Research, 2017 , vol. 6, # 2 p. 109 - 125 Title/Abstract Full Text Show Details
Comiran, Eloisa; Barreto, Fabiano; Meneghini, Leonardo Z.; Carlos, Graciela; Fröehlich, Pedro E.; Limberger, Renata Pereira
Biomedical Chromatography, 2017 , vol. 31, # 3 art. no. E3812 Title/Abstract Full Text Show Details
Ghadiri, Ameneh; Etemad, Leila; Moshiri, Mohammad; Moallem, Seyed Adel; Jafarian, Amir Hossein; Hadizadeh, Farzin; Seifi, Mahmoud
Iranian Journal of Basic Medical Sciences, 2017 , vol. 20, # 2 p. 138 - 144 Title/Abstract Full Text Show Details
Dinis-Oliveira, Ricardo Jorge
European Journal of Drug Metabolism and Pharmacokinetics, 2017 , vol. 42, # 1 p. 11 - 16 Title/Abstract Full Text Show Details
Lin, Zebin; Li, Jiaolun; Zhang, Xinyu; Qiu, Meihong; Huang, Zhibin; Rao, Yulan
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2017 , vol. 1046, p. 177 - 184 Title/Abstract Full Text Show Details
Caballero-Puntiverio, Maitane; Fitzpatrick, Ciarán Martin; Woldbye, David P.D.; Andreasen, Jesper Tobias
Journal of Psychopharmacology, 2017 , vol. 31, # 2 p. 272 - 283 Title/Abstract Full Text Show Details
Cross, Sarah J.; Lotfipour, Shahrdad; Leslie, Frances M.
American Journal of Drug and Alcohol Abuse, 2017 , vol. 43, # 2 p. 171 - 185 Title/Abstract Full Text Show Details
Kohut, Stephen J.
American Journal of Drug and Alcohol Abuse, 2017 , vol. 43, # 2 p. 155 - 170 Title/Abstract Full Text Show Details
Ford, Loretta T; Berg, Jonathan D
Annals of Clinical Biochemistry, 2017 , vol. 54, # 2 p. 219 - 229 Title/Abstract Full Text Show Details
Ruzza, Chiara; Calò, Girolamo; Di Maro, Salvatore; Pacifico, Salvatore; Trapella, Claudio; Salvadori, Severo; Preti, Delia; Guerrini, Remo
Expert Opinion on Therapeutic Patents, 2017 , vol. 27, # 3 p. 347 - 362 Title/Abstract Full Text Show Details
Wong, Scott A.; Thapa, Raj; Badenhorst, Cecilia A.; Briggs, Alicia R.; Sawada, Justan A.; Gruber, Aaron J.
Neuroscience, 2017 , vol. 345, p. 218 - 228 Title/Abstract Full Text Show Details
Bailey, Matthew R.; Simpson, Eleanor H.; Balsam, Peter D.
Neurobiology of Learning and Memory, 2016 , vol. 133, p. 233 - 256 Title/Abstract Full Text Show Details
Comment (Pharmacological Data)
Bioactivities present
Reference
Dunn, Matthew
International Journal of Drug Policy, 2017 , vol. 40, p. 26 - 34 Title/Abstract Full Text Show Details
Riley, Elise D.; Hsue, Priscilla Y.; Vittinghoff, Eric; Wu, Alan H.B.; Coffin, Phillip O.; Moore, Peter K.; Lynch, Kara L.
Drug and Alcohol Dependence, 2017 , vol. 172, p. 88 - 93 Title/Abstract Full Text Show Details
Barkhuizen; van den Hove; Vles; Steinbusch; Kramer; Gavilanes
Neuroscience and Biobehavioral Reviews, 2017 , vol. 75, p. 166 - 182 Title/Abstract Full Text Show Details
Kopra, Jaakko J.; Panhelainen, Anne; af Bjerkén, Sara; Porokuokka, Lauriina L.; Varendi, Kärt; Olfat, Soophie; Montonen, Heidi; Piepponen, T. Petteri; Saarma, Mart; Andressoo, Jaan-Olle
Journal of Neuroscience, 2017 , vol. 37, # 6 p. 1581 - 1590 Title/Abstract Full Text Show Details
Abiedalla, Younis; DeRuiter, Jack; Clark, C. Randall
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2017 , vol. 1048, p. 38 - 48 Title/Abstract Full Text Show Details
Feio-Azevedo; Costa; Ferreira; Branco; Pereira; Bastos; Carvalho; Capela
Toxicology Letters, 2017 , vol. 269, p. 65 - 76 Title/Abstract Full Text Show Details
Weidenauer, Ana; Bauer, Martin; Sauerzopf, Ulrich; Bartova, Lucie; Praschak-Rieder, Nicole; Sitte, Harald H.; Kasper, Siegfried; Willeit, Matthäus
International Journal of Neuropsychopharmacology, 2017 , vol. 20, # 1 Title/Abstract Full Text Show Details
Atabay, Ender; Rodopman Arman, Ayşe
Marmara Medical Journal, 2016 , vol. 29, # 3 p. 177 - 180 Title/Abstract Full Text Show Details
Fields, Scott A.; Johnson, William Michael; Hassig, Madison B.
Journal of Family Practice, 2017 , vol. 66, # 2 p. 68 - 74 Title/Abstract Full Text Show Details
Wijers, Charlotte H W; van Litsenburg, Ronald T H; Hondebrink, Laura; Niesink, Raymond J M; Croes, Esther A
The Lancet, 2017 , vol. 389, # 10069 p. 600 - 600 Title/Abstract Full Text Show Details
Smith, Tess E.; Martel, Michelle M.; DeSantis, Alan D.
Substance Use and Misuse, 2017 , vol. 52, # 4 p. 548 - 552 Title/Abstract Full Text Show Details
Akhgari, Maryam; Mobaraki, Homeira; Etemadi-Aleagha, Afshar
DARU, Journal of Pharmaceutical Sciences, 2017 , vol. 25, # 1 art. no. 5 Title/Abstract Full Text Show Details
Fletcher, Paul J.; Zeeb, Fiona D.; Browne, Caleb J.; Higgins, Guy A.; Soko, Ashlie D.
Psychopharmacology, 2017 , vol. 234, # 5 p. 889 - 902 Title/Abstract Full Text Show Details
Rendon, Alexis; Livingston, Melvin; Suzuki, Sumihiro; Hill, Whitney; Walters, Scott
Addictive Behaviors, 2017 , vol. 70, p. 90 - 96 Title/Abstract Full Text Show Details
Mansukhani, Meghna P.; Kolla, Bhanu Prakash; Park, John G.
Sleep Medicine, 2017 , vol. 32, p. 171 - 175 Title/Abstract Full Text Show Details
Becker, Jill B.
Dialogues in Clinical Neuroscience, 2016 , vol. 18, # 4 p. 395 - 402 Title/Abstract Full Text Show Details
Nishi, Akinori; Shuto, Takahide
Expert Opinion on Therapeutic Targets, 2017 , vol. 21, # 3 p. 259 - 272 Title/Abstract Full Text Show Details
Müller, Thomas; Foley, Paul
Clinical Pharmacokinetics, 2017 , vol. 56, # 3 p. 251 - 261 Title/Abstract Full Text Show Details
Moein, Mohammad Mahdi; El Beqqali, Aziza; Abdel-Rehim, Mohamed
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2017 , vol. 1043, p. 3 - 11 Title/Abstract Full Text Show Details
León, Kenneth S.; Martínez, Daniel E.
Journal of Psychoactive Drugs, 2017 , vol. 49, # 1 p. 22 - 30 Title/Abstract Full Text Show Details
88 of 317
Comment (Pharmacological Data)
Bioactivities present
Reference
Helfer, Andreas G.; Michely, Julian A.; Weber, Armin A.; Meyer, Markus R.; Maurer, Hans H.
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2017 , vol. 1043, p. 138 - 149 Title/Abstract Full Text Show Details
Filippou, Olga; Bitas, Dimitrios; Samanidou, Victoria
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2017 , vol. 1043, p. 44 - 62 Title/Abstract Full Text Show Details
Lopez; Arnulf; Drouot; Lecendreux; Dauvilliers
Revue Neurologique, 2017 , vol. 173, # 1-2 p. 8 - 18 Title/Abstract Full Text Show Details
Nazario, Carlos Eduardo Domingues; Fumes, Bruno Henrique; da Silva, Meire Ribeiro; Lanças, Fernando Mauro
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2017 , vol. 1043, p. 81 - 95 Title/Abstract Full Text Show Details
Jalewa, Jaishree; Sharma, Mohit Kumar; Gengler, Simon; Hölscher, Christian
Neuropharmacology, 2017 , vol. 117, p. 238 - 248 Title/Abstract Full Text Show Details
Vasconcelos, Ingrid; Fernandes, Christian
TrAC - Trends in Analytical Chemistry, 2017 , vol. 89, p. 41 - 52 Title/Abstract Full Text Show Details
Dalley, Jeffrey W.; Robbins, Trevor W.
Nature Reviews Neuroscience, 2017 , vol. 18, # 3 p. 158 - 171 Title/Abstract Full Text Show Details
Ortega, Leonardo A.; Solano, José L.; Torres, Carmen; Papini, Mauricio R.
Pharmacology Biochemistry and Behavior, 2017 , vol. 154, p. 39 - 52
Title/Abstract Full Text Show Details
Gonzáles, Marco A.; Miranda, Ana Pamela; Orrego, Horacio; Silva, Rodolfo; Forray, María Inés
Neuropharmacology, 2017 , vol. 117, p. 249 - 259 Title/Abstract Full Text Show Details
Toce, Michael S.; Farias, Michael; Bruccoleri, Rebecca; Brown, David W.; Burns, Michele M.
Journal of Pediatrics, 2017 , vol. 182, p. 385 - 3,388 Title/Abstract Full Text Show Details
Turcant, Alain; Deguigne, Marie; Ferec, Séverine; Bruneau, Chloé; Leborgne, Isabelle; Lelievre, Bénédicte; Gegu, Clément; Jegou, Florence; Abbara, Chadi; Le Roux, Gaël; Boels, David
Toxicologie Analytique et Clinique, 2017 , vol. 29, # 1 p. 18 - 33 Title/Abstract Full Text Show Details
Dumestre-Toulet, Véronique; Brault, Sandrine; Labadie, Magali; Penouil-Pucheu, Françoise
Toxicologie Analytique et Clinique, 2017 , vol. 29, # 1 p. 111 - 116 Title/Abstract Full Text Show Details
Deslandes, Guillaume; Monteil-Ganière, Catherine; Grégoire, Matthieu; Allard, Sophie; Marion, Maria; Bouquié, Régis
Toxicologie Analytique et Clinique, 2017 , vol. 29, # 1 p. 134 - 138 Title/Abstract Full Text Show Details
Abbara, Chadi; Ferec, Séverine; Leroux, Gaël; Bretaudeau-Deguigne, Marie; Lelievre, Bénédicte; Boels, David; Turcant, Alain Toxicologie Analytique et Clinique, 2017 , vol. 29, # 1 p. 82 - 89 Title/Abstract Full Text Show Details
Batisse, Anne; Marillier, Maude; Chevallier, Cécile; Bourgogne, Emmanuel; Grégoire, Muriel; Laprévote, Olivier; Djezzar, Samira
Toxicologie Analytique et Clinique, 2017 , vol. 29, # 1 p. 96 - 100 Title/Abstract Full Text Show Details
Nachon-Phanithavong, Mélodie; Wille, Sarah; Richeval, Camille; Di Fazio, Vincent; Samyn, Nele; Humbert, Luc; Gaulier, Jean-Michel; Allorge, Delphine
Toxicologie Analytique et Clinique, 2017 , vol. 29, # 1 p. 41 - 46 Title/Abstract Full Text Show Details
Wille, Sarah M.R.; Eliaerts, Joy; Di Fazio, Vincent; Samyn, Nele
Toxicologie Analytique et Clinique, 2017 , vol. 29, # 1 p. 11 - 17 Title/Abstract Full Text Show Details
Bottinelli, Charline; Cartiser, Nathalie; Gaillard, Yvan; Boyer, Baptiste; Bévalot, Fabien
Toxicologie Analytique et Clinique, 2017 , vol. 29, # 1 p. 123 - 129 Title/Abstract Full Text Show Details
Allibe, Nathalie; Richeval, Camille; Willeman, Théo; Humbert, Luc; Allorge, Delphine; Maignan, Maxime; Eysseric-Guerin, Hélène; Stanke-Labesque, Françoise; Gaulier, Jean-Michel
Toxicologie Analytique et Clinique, 2017 , vol. 29, # 1 p. 101 - 110 Title/Abstract Full Text Show Details
Abiedalla, Younis; DeRuiter, Jack; Clark, C. Randall
Forensic Chemistry, 2017 , vol. 3, p. 58 - 68 Title/Abstract Full Text Show Details
89 of 317
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Comment (Pharmacological Data)
Bioactivities present
Reference
Kelly, Peter J.; Robinson, Laura D.; Baker, Amanda L.; Deane, Frank P.; McKetin, Rebecca; Hudson, Suzie; Keane, Carol
Addictive Behaviors, 2017 , vol. 71, p. 25 - 30 Title/Abstract Full Text Show Details
Yu, Ching-Han; Chu, Shu-Chen; Chen, Pei-Ni; Hsieh, Yih-Shou; Kuo, Dong-Yih
Appetite, 2017 , vol. 113, p. 30 - 40 Title/Abstract Full Text Show Details
Wood, Michael R.; Noetzel, Meredith J.; Melancon, Bruce J.; Poslusney, Michael S.; Nance, Kellie D.; Hurtado, Miguel A.; Luscombe, Vincent B.; Weiner, Rebecca L.; Rodriguez, Alice L.; Lamsal, Atin; Chang, Sichen; Bubser, Michael; Blobaum, Anna L.; Engers, Darren W.; Niswender, Colleen M.; Jones, Carrie K.; Brandon, Nicholas J.; Wood, Michael W.; Duggan, Mark E.; Conn, P. Jeffrey; Bridges, Thomas M.; Lindsley, Craig W.
ACS Medicinal Chemistry Letters, 2017 , vol. 8, # 2 p. 233 - 238 Title/Abstract Full Text Show Details
Comment (Pharmacological Data)
physiological behaviour discussed
Reference
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.; UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL – UFRGS; UNIVERSIDADE DE SÃO PAULO - USP; MECHOULAM, Raphael; BREUER, Aviva; PEREIRA KAPCZINSKI, Flavio; DE SOUZA CRIPPA, Jose Alexandre; ZUARDI, Antonio Waldo; CECILIO HALLAK, Jaime Eduardo; SILVEIRA GUIMARAES, Francisco
Patent: WO2017/8136 A2, 2017 ; Title/Abstract Full Text Show Details
91 of 317
92 of 317
Comment (Pharmacological Data)
physiological behaviour discussed
Reference
Wood, Michael R.; Noetzel, Meredith J.; Melancon, Bruce J.; Poslusney, Michael S.; Nance, Kellie D.; Hurtado, Miguel A.; Luscombe, Vincent B.; Weiner, Rebecca L.; Rodriguez, Alice L.; Lamsal, Atin; Chang, Sichen; Bubser, Michael; Blobaum, Anna L.; Engers, Darren W.; Niswender, Colleen M.; Jones, Carrie K.; Brandon, Nicholas J.; Wood, Michael W.; Duggan, Mark E.; Conn, P. Jeffrey; Bridges, Thomas M.; Lindsley, Craig W.
ACS Medicinal Chemistry Letters, 2017 , vol. 8, # 2 p. 233 - 238 Title/Abstract Full Text Show Details
Comment
physiological behaviour discussed
(Pharmacological Data) Reference
Inceptum Research and Therapeutics, Inc.; Mastronardi, Fabrizio G.
Patent: US9259409 B2, 2016 ; Title/Abstract Full Text Show Details
93 of 317
Comment (Pharmacological Data)
physiological behaviour discussed
Reference
RUGEN HOLDINGS (CAYMAN) LIMITED; SHAPIRO, Gideon
Patent: WO2016/44323 A1, 2016 ; Title/Abstract Full Text Show Details
94 of 317
95 of 317
Comment (Pharmacological Data)
physiological behaviour discussed
Reference
Macúchová; Ševčíková; Hrebíčková; Nohejlová; Šlamberová
International Journal of Developmental Neuroscience, 2016 , vol. 51, p. 1 - 11 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
physiological behaviour discussed
Reference
H. LUNDBECK A/S; LARSEN, Lone Frydelund; AREBERG, Johan; BREYSSE, Nathalie; CHANDRASENA, Gamini
Patent: WO2016/87429 A1, 2016 ; Title/Abstract Full Text Show Details
96 of 317
Comment (Pharmacological Data)
physiological behaviour discussed
Reference
Noven Pharmaceuticals, Inc.; Liu, Puchun; Dinh, Steven; Liao, Jun; Endo, Tsuyoshi
Patent: US2016/256406 A1, 2016 ; Title/Abstract Full Text Show Details
97 of 317
Comment (Pharmacological Data)
physiological behaviour discussed
Reference
UNIVERSITY OF KANSAS; UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.; GOLDEN, Jennifer E.; CHUNG, Donghoon
Patent: WO2016/183093 A1, 2016 ; Title/Abstract Full Text Show Details
98 of 317
99 of 317
Comment (Pharmacological Data)
physiological behaviour discussed
Reference
Shen, Erica Y.; Jiang, Yan; Javidfar, Behnam; Kassim, Bibi; Loh, Yong-Hwee E.; Ma, Qi; Mitchell, Amanda C.; Pothula, Venu; Stewart, A Francis; Ernst, Patricia; Yao, Wei-Dong; Martin, Gilles; Shen, Li; Jakovcevski, Mira; Akbarian, Schahram
Neuropsychopharmacology, 2016 , vol. 41, # 13 p. 3103 - 3113 Title/Abstract Full Text Show Details
Comment (Pharmacological Data)
physiological behaviour discussed
Reference
RUGEN HOLDINGS (CAYMAN) LIMITED; SHAPIRO, Gideon
Patent: WO2016/196513 A1, 2016 ; Title/Abstract Full Text Show Details
100 of 317
101 of 317
Comment (Pharmacological Data)
physiological behaviour discussed
Reference
Urs, Nikhil M.; Gee, Steven M.; Pack, Thomas F.; McCorvy, John D.; Evron, Tama; Snyder, Joshua C.; Yang, Xiaobao; Rodriguiz, Ramona M.; Borrelli, Emiliana; Wetsel, William C.; Jin, Jian; Roth, Bryan L.; O'Donnell, Patricio; Caron, Marc G.; Snyder, Solomon H.
Proceedings of the National Academy of Sciences of the United States of America, 2016 , vol. 113, # 50 p. E8178 - E8186 Title/Abstract Full Text Show Details
Comment
physiological behaviour discussed
(Pharmacological Data)
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Reference
Sucic, Sonja; Bönisch, Heinz
Neuromethods, 2016 , vol. 118, p. 1 - 21 Title/Abstract Full Text Show Details
Comment (Pharmacological Data)
physiological behaviour discussed
Reference
CUREMARK, LLC; Fallon, Joan M.; Heil, Matthew; Szigethy, James; Fallon, James
Patent: US9492515 B2, 2016 ; Title/Abstract Full Text Show Details
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Comment (Pharmacological Data)
physiological behaviour discussed
Reference
Szacoń, Elbieta; Rzdkowska, Marzena; Kaczor, Agnieszka A.; Kędzierska, Ewa; Fidecka, Sylwia; Matosiuk, Dariusz
Molecules, 2015 , vol. 20, # 3 p. 3821 - 3840 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
physiological behaviour discussed
Reference
Nirogi, Ramakrishna; Palacharla, Raghava Choudary; Mohammed, Abdul Rasheed; Manoharan, Arunkumar; Ponnamaneni, Ranjith Kumar; Bhyrapuneni, Gopinadh
Chemico-Biological Interactions, 2015 , vol. 230, p. 9 - 20 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
physiological behaviour discussed
Reference
Tominaga, Mariko; Michiue, Tomomi; Ishikawa, Takaki; Inamori-Kawamoto, Osamu; Oritani, Shigeki; Maeda, Hitoshi
Forensic Science International, 2015 , vol. 254, p. 118 - 125 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
physiological behaviour discussed
Reference
Randox Laboratories Ltd.; Benchik, Elouard; Fitzgerald, Peter; Lowry, Philip; McConnell, Ivan
Patent: EP2950104 A1, 2015 ; Title/Abstract Full Text Show Details
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Comment (Pharmacological Data)
physiological behaviour discussed
Reference
NORTHEASTERN UNIVERSITY; BOOTH, Raymond, G.
Patent: WO2015/179366 A1, 2015 ; Title/Abstract Full Text Show Details
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Comment (Pharmacological Data)
physiological behaviour discussed
Reference
Finnema, Sjoerd J.; Hughes, Zoë A.; Haaparanta-Solin, Merja; Stepanov, Vladimir; Nakao, Ryuji; Varnäs, Katarina; Varrone, Andrea; Arponen, Eveliina; Marjamäki, Päivi; Pohjanoksa, Katariina; Vuorilehto, Lauri; Babalola, Phebian A.; Solin, Olof; Grimwood, Sarah; Sallinen, Jukka; Farde, Lars; Scheinin, Mika; Halldin, Christer
International Journal of Neuropsychopharmacology, 2015 , vol. 18, # 3 Title/Abstract Full Text Show Details
Comment (Pharmacological Data)
physiological behaviour discussed
Reference
Tanno, Takayuki; Maguire, David R.; Henson, Cedric; France, Charles P.
Psychopharmacology, 2014 , vol. 231, # 1 p. 85 - 95 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
physiological behaviour discussed
Reference
Calipari, Erin S.; Ferris, Mark J.; Siciliano, Cody A.; Zimmer, Benjamin A.; Jones, Sara R.
Journal of Pharmacology and Experimental Therapeutics, 2014 , vol. 349, # 2 p. 192 - 198 Title/Abstract Full Text View citing articles Show Details
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Comment (Pharmacological Data)
physiological behaviour discussed
Reference
Chu, Shu-Chen; Chen, Pei-Ni; Hsieh, Yih-Shou; Yu, Ching-Han; Lin, Meng-Hsuan; Lin, Yan-Han; Kuo, Dong-Yih
British Journal of Pharmacology, 2014 , vol. 171, # 13 p. 3223 - 3233 Title/Abstract Full Text View citing articles Show Details
Location
Paragraph
Comment (Pharmacological Data)
physiological behaviour discussed
Reference
Akhapkina, Valentina Ivanovna; Akhapkin, Roman Vitalyevich
Patent: EP2762138 A1, 2014 ; Title/Abstract Full Text Show Details
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Comment (Pharmacological Data)
physiological behaviour discussed
Reference
Alvaro, Giuseppe; Marasco, Agostino
Patent: US2014/323508 A1, 2014 ; Title/Abstract Full Text Show Details
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Comment (Pharmacological Data)
physiological behaviour discussed
Reference
PHILADELPHIA HEALTH AND EDUCATION CORPORATION D/B/A DREXEL UNIVERSITY COLLEGE OF MEDICINE; KORTAGERE, Sandhya; MORTENSEN, Ole Valente; MORTENSEN, Andreia C.K.
Patent: WO2014/172453 A2, 2014 ; Title/Abstract Full Text Show Details
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Comment (Pharmacological Data)
physiological behaviour discussed
Reference
Bubser, Michael; Bridges, Thomas M.; Dencker, Ditte; Gould, Robert W.; Grannan, Michael; Noetzel, Meredith J.; Lamsal, Atin; Niswender, Colleen M.; Daniels, J. Scott; Poslusney, Michael S.; Melancon, Bruce J.; Tarr, James C.; Byers, Frank W.; Wess, Jürgen; Duggan, Mark E.; Dunlop, John; Wood, Michael W.; Brandon, Nicholas J.; Wood, Michael R.; Lindsley, Craig W.; Conn, P. Jeffrey; Jones, Carrie K.
ACS Chemical Neuroscience, 2014 , vol. 5, # 10 p. 920 - 942 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
physiological behaviour discussed
Reference
Slawinska, Anna; Wieronska, Joanna M.; Stachowicz, Katarzyna; Marciniak, Marcin; Lason-Tyburkiewicz, Magdalena; Gruca, Piotr; Papp, Mariusz; Kusek, Magdalena; Tokarski, Krzysztof; Doller, Dario; Pilc, Andrzej
British Journal of Pharmacology, 2013 , vol. 169, # 8 p. 1824 - 1839 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
Δ9-tetrahydrocannabinol discriminative stimulus; inhibition of
Species or TestSystem (Pharmacological Data)
Macaca mulatta, rhesus monkey
Sex
male and female
Route of Application
bolus (i.v.)
Concentration (Pharmacological Data)
0.32 mg/kg
Further Details (Pharmacological Data)
test system discriminated Δ9-tetrahydrocannabinol from vehicle
Results
no effect
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Reference
Schulze, David R.; Carroll, F. Ivy; McMahon, Lance R.
Psychopharmacology, 2012 , vol. 222, # 3 p. 425 - 438 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
Δ9-tetrahydrocannabinol discriminative stimulus; inhibition of
Species or TestSystem (Pharmacological Data)
Macaca mulatta, rhesus monkey
Sex
male and female
Route of Application
bolus (i.v.)
Concentration (Pharmacological Data)
1 mg/kg
Further Details (Pharmacological Data)
test system discriminated Δ9-tetrahydrocannabinol from vehicle; ED50 value of Δ9-tetrahydrocannabinol alone: 0.042 mg/kg
Type (Pharmacological Data)
ED50
Value of Type (Pharmacological Data)
0.32 mg/kg
Reference
Schulze, David R.; Carroll, F. Ivy; McMahon, Lance R.
Psychopharmacology, 2012 , vol. 222, # 3 p. 425 - 438 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
conditioned place preference; induction of
Species or TestSystem (Pharmacological Data)
Microtus ochrogaster, prairie vole
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
0.1 - 5 mg/kg
Kind of Dosing (Pharmacological Data)
title compound was prepared in saline; injected during 3 days (day 2-4) of conditioning
Type (Pharmacological Data)
effective dose
Value of Type (Pharmacological Data)
1 - 5 mg/kg
Reference
Liu, Yan; Aragona, Brandon J.; Young, Kimberly A.; Dietz, David M.; Kabbaj, Mohamed; Mazei-Robison, Michelle; Nestler, Eric J.; Wang, Zuoxin
Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 3 p. 1217 - 1222 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
mating-induced partner preferences; inhibition of
Species or TestSystem (Pharmacological Data)
Microtus ochrogaster, prairie vole
Sex
male
Route of Application
intraperitoneal
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Concentration (Pharmacological Data)
1 - 5 mg/kg
Kind of Dosing (Pharmacological Data)
title compound was prepared in saline; injected during 3 days (day 2-4) of conditioning
Type (Pharmacological Data)
effective dose
Value of Type (Pharmacological Data)
1 - 5 mg/kg
Reference
Liu, Yan; Aragona, Brandon J.; Young, Kimberly A.; Dietz, David M.; Kabbaj, Mohamed; Mazei-Robison, Michelle; Nestler, Eric J.; Wang, Zuoxin
Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 3 p. 1217 - 1222 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
mating frequency; inhibition of
Species or TestSystem (Pharmacological Data)
Microtus ochrogaster, prairie vole
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
1 - 5 mg/kg
Kind of Dosing (Pharmacological Data)
title compound was prepared in saline; injected during 3 days (day 2-4) of conditioning
Results
no effect
Reference
Liu, Yan; Aragona, Brandon J.; Young, Kimberly A.; Dietz, David M.; Kabbaj, Mohamed; Mazei-Robison, Michelle; Nestler, Eric J.; Wang, Zuoxin
Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 3 p. 1217 - 1222 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
locomotor activity; inhibition of
Species or TestSystem (Pharmacological Data)
Microtus ochrogaster, prairie vole
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
1 - 5 mg/kg
Kind of Dosing (Pharmacological Data)
title compound was prepared in saline; injected during 3 days (day 2-4) of conditioning
Results
no effect
Reference
Liu, Yan; Aragona, Brandon J.; Young, Kimberly A.; Dietz, David M.; Kabbaj, Mohamed; Mazei-Robison, Michelle; Nestler, Eric J.; Wang, Zuoxin
Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 3 p. 1217 - 1222 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
conditioned place preference; induction of
Species or TestSystem (Pharmacological Data)
Microtus ochrogaster, prairie vole
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Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
1 mg/kg
Kind of Dosing (Pharmacological Data)
title compound was prepared in saline; injected during 3 days (day 2-4) of conditioning after haloperidol or SCH23390
Further Details (Pharmacological Data)
haloperidol: nonselective dopamine receptor antagonist; SCH23390: D1-like dopamine receptor antagonist
Results
no effect
Reference
Liu, Yan; Aragona, Brandon J.; Young, Kimberly A.; Dietz, David M.; Kabbaj, Mohamed; Mazei-Robison, Michelle; Nestler, Eric J.; Wang, Zuoxin
Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 3 p. 1217 - 1222 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
conditioned place preference; induction of
Species or TestSystem (Pharmacological Data)
Microtus ochrogaster, prairie vole
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
1 mg/kg
Kind of Dosing (Pharmacological Data)
title compound was prepared in saline; injected during 3 days (day 2-4) of conditioning after eticlopride
Further Details (Pharmacological Data)
eticlopride: D2-like dopamine receptor antagonist
Type (Pharmacological Data)
effective dose
Value of Type (Pharmacological Data)
1 mg/kg
Reference
Liu, Yan; Aragona, Brandon J.; Young, Kimberly A.; Dietz, David M.; Kabbaj, Mohamed; Mazei-Robison, Michelle; Nestler, Eric J.; Wang, Zuoxin
Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 3 p. 1217 - 1222 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
density of D1R mRNA in NAcc; increase of
Species or TestSystem (Pharmacological Data)
Microtus ochrogaster, prairie vole
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
1 mg/kg
Kind of Dosing (Pharmacological Data)
title compound was prepared in saline; injected during 3 days (day 2-4) of conditioning
Further Details (Pharmacological Data)
D1R: D1 dopamine receptor; NAcc: nucleus accumbens; effective dose related to: nucleus accumbens
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Type (Pharmacological Data)
effective dose
Value of Type (Pharmacological Data)
1 mg/kg
Reference
Liu, Yan; Aragona, Brandon J.; Young, Kimberly A.; Dietz, David M.; Kabbaj, Mohamed; Mazei-Robison, Michelle; Nestler, Eric J.; Wang, Zuoxin
Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 3 p. 1217 - 1222 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
density of D2R mRNA in NAcc; increase of
Species or TestSystem (Pharmacological Data)
Microtus ochrogaster, prairie vole
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
1 mg/kg
Kind of Dosing (Pharmacological Data)
title compound was prepared in saline; injected during 3 days (day 2-4) of conditioning
Further Details (Pharmacological Data)
D2R: D2 dopamine receptor; NAcc: nucleus accumbens
Results
no effect
Reference
Liu, Yan; Aragona, Brandon J.; Young, Kimberly A.; Dietz, David M.; Kabbaj, Mohamed; Mazei-Robison, Michelle; Nestler, Eric J.; Wang, Zuoxin
Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 3 p. 1217 - 1222 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
expression of D2R mRNA in ventral tegmental area; increase of
Species or TestSystem (Pharmacological Data)
Microtus ochrogaster, prairie vole
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
1 mg/kg
Kind of Dosing (Pharmacological Data)
title compound was prepared in saline; injected during 3 days (day 2-4) of conditioning
Further Details (Pharmacological Data)
D2R: D2 dopamine receptor
Results
no effect
Reference
Liu, Yan; Aragona, Brandon J.; Young, Kimberly A.; Dietz, David M.; Kabbaj, Mohamed; Mazei-Robison, Michelle; Nestler, Eric J.; Wang, Zuoxin
Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 3 p. 1217 - 1222 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
expression of tyrosine hydroxylase mRNA in ventral tegmental area; increase of
Species or TestSystem (Pharmacological Data)
Microtus ochrogaster, prairie vole
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Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
1 mg/kg
Kind of Dosing (Pharmacological Data)
title compound was prepared in saline; injected during 3 days (day 2-4) of conditioning
Results
no effect
Reference
Liu, Yan; Aragona, Brandon J.; Young, Kimberly A.; Dietz, David M.; Kabbaj, Mohamed; Mazei-Robison, Michelle; Nestler, Eric J.; Wang, Zuoxin
Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 3 p. 1217 - 1222 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
expression of DA transporter mRNA in ventral tegmental area; increase of
Species or TestSystem (Pharmacological Data)
Microtus ochrogaster, prairie vole
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
1 mg/kg
Kind of Dosing (Pharmacological Data)
title compound was prepared in saline; injected during 3 days (day 2-4) of conditioning
Further Details (Pharmacological Data)
DA: dopamine
Results
no effect
Reference
Liu, Yan; Aragona, Brandon J.; Young, Kimberly A.; Dietz, David M.; Kabbaj, Mohamed; Mazei-Robison, Michelle; Nestler, Eric J.; Wang, Zuoxin
Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 3 p. 1217 - 1222 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
mating-induced partner preferences; inhibition of
Species or TestSystem (Pharmacological Data)
Microtus ochrogaster, prairie vole
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
1 - 5 mg/kg
Kind of Dosing (Pharmacological Data)
title compound was prepared in saline; injected during 3 days (day 2-4) of conditioning after SCH23390 (0.4 ng/kg) intra-NAcc injection
Further Details (Pharmacological Data)
NAcc: nucleus accumbens; SCH23390: D1-like receptor antagonist; effective dose related to: nucleus accumbens
Type (Pharmacological Data)
effective dose
Value of Type (Pharmacological Data)
1 mg/kg
Reference
Liu, Yan; Aragona, Brandon J.; Young, Kimberly A.; Dietz, David M.; Kabbaj, Mohamed; Mazei-Robison, Michelle; Nestler,
Eric J.; Wang, Zuoxin
Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 3 p. 1217 - 1222 Title/Abstract Full Text View citing articles Show Details
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Effect (Pharmacological Data)
mating-induced partner preferences; inhibition of
Species or TestSystem (Pharmacological Data)
Microtus ochrogaster, prairie vole
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
1 - 5 mg/kg
Kind of Dosing (Pharmacological Data)
title compound was prepared in saline; injected during 3 days (day 2-4) of conditioning after SCH23390 (100 ng/kg) intra-NAcc injection
Further Details (Pharmacological Data)
NAcc: nucleus accumbens; SCH23390: D1-like receptor antagonist
Results
no effect (related to nucleus accumbens)
Reference
Liu, Yan; Aragona, Brandon J.; Young, Kimberly A.; Dietz, David M.; Kabbaj, Mohamed; Mazei-Robison, Michelle; Nestler, Eric J.; Wang, Zuoxin
Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 3 p. 1217 - 1222 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
prepulse intensity; suppression of
Species or TestSystem (Pharmacological Data)
mouse
Sex
male and female
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
1 - 10 mg/kg
Further Details (Pharmacological Data)
not clear from the article neurotensin-1 receptor null or wild type mice; 4-16 db acoustic stimulation
Type (Pharmacological Data)
prepulse inhibition
Value of Type (Pharmacological Data)
8.77 - 70.64 percent
Reference
Feifel; Pang; Shilling; Melendez; Schreiber; Button
Neuropharmacology, 2010 , vol. 58, # 1 p. 173 - 178 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
duration of immobility; decrease of
Species or TestSystem (Pharmacological Data)
Swiss albino mouse
Sex
male and female
Route of Application
peroral
Concentration (Pharmacological
5 mg/kg
Data)
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Kind of Dosing (Pharmacological Data)
comparative comp. administered as sulphate
Further Details (Pharmacological Data)
duration of immobility in control: 370 s; mass of species: 18 - 25 g
Type (Pharmacological Data)
duration of immobility
Value of Type (Pharmacological Data)
33.2 s
Reference
Umukoro, Solomon; Aladeokin, Aderemi Caleb
Journal of Ethnopharmacology, 2010 , vol. 127, # 3 p. 768 - 770 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
pharmacokinetics
Species or TestSystem (Pharmacological Data)
Caco-2 cells seeded artificial membrane
Concentration (Pharmacological Data)
10 μmol/l
Kind of Dosing (Pharmacological Data)
title comp. dissolved in DMSO
Further Details (Pharmacological Data)
permeability coefficient A-B (Papp, A-B)
Type (Pharmacological Data)
Papp, A-B
Value of Type (Pharmacological Data)
40.35*1E-6 cm/s
Reference
Skolnik, Suzanne; Lin, Xuena; Wang, Jianling; Chen, Xiao-Hui; He, Timothy; Zhang, Bailin
Journal of Pharmaceutical Sciences, 2010 , vol. 99, # 7 p. 3246 - 3265 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
pharmacokinetics
Species or TestSystem (Pharmacological Data)
Caco-2 cells seeded artificial membrane
Concentration (Pharmacological Data)
10 μmol/l
Kind of Dosing (Pharmacological Data)
title comp. dissolved in DMSO
Further Details (Pharmacological Data)
permeability coefficient B-A (Papp, B-A)
Type (Pharmacological Data)
Papp, B-A
Value of Type (Pharmacological Data)
21.14*1E-6 cm/s
Reference
Skolnik, Suzanne; Lin, Xuena; Wang, Jianling; Chen, Xiao-Hui; He, Timothy; Zhang, Bailin
Journal of Pharmaceutical Sciences, 2010 , vol. 99, # 7 p. 3246 - 3265 Title/Abstract Full Text View citing articles Show Details
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Effect (Pharmacological Data)
basal dopamine outflow; induction of
Species or TestSystem (Pharmacological Data)
Sprague-Dawley rat
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
0.5 mg/kg
Kind of Dosing (Pharmacological Data)
title comp. admnistered as sulfate
Further Details (Pharmacological Data)
mass of species: 330 - 380 g; dopamine outflow rate related to: striatum
Type (Pharmacological Data)
dopamine outflow rate
Value of Type (Pharmacological Data)
Ca. 324 percent
Reference
Auclair, Agnes L.; Cathala, Adeline; Sarrazin, Frederic; Depoortere, Ronan; Piazza, Pier Vincenzo; Newman-Tancredi, Adrian; Spampinato, Umberto
Journal of Neurochemistry, 2010 , vol. 114, # 5 p. 1323 - 1332 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
basal dopamine outflow; induction of
Species or TestSystem (Pharmacological Data)
Sprague-Dawley rat
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
0.5 mg/kg
Kind of Dosing (Pharmacological Data)
title comp. admnistered as sulfate
Further Details (Pharmacological Data)
mass of species: 330 - 380 g; dopamine outflow rate related to: nucleus accumbens
Type (Pharmacological Data)
dopamine outflow rate
Value of Type (Pharmacological Data)
Ca. 349 perent
Reference
Auclair, Agnes L.; Cathala, Adeline; Sarrazin, Frederic; Depoortere, Ronan; Piazza, Pier Vincenzo; Newman-Tancredi, Adrian; Spampinato, Umberto
Journal of Neurochemistry, 2010 , vol. 114, # 5 p. 1323 - 1332 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
enzyme activity; inhibition of
Species or TestSystem (Pharmacological Data)
brain mitochondria of rat
Further Details
inhibition constant (Ki); Ki related to: monoamine oxidase A
(Pharmacological Data)
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Type (Pharmacological Data)
Ki
Value of Type (Pharmacological Data)
12.2 μmol/l
Reference
Vilches-Herrera, Marcelo; Miranda-Sepulveda, Juan; Rebolledo-Fuentes, Marco; Fierro, Angelica; Luehr, Susan; IturriagaVasquez, Patricio; Cassels, Bruce K.; Reyes-Parada, Miguel
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 6 p. 2452 - 2460 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
enzyme activity; inhibition of
Species or TestSystem (Pharmacological Data)
brain mitochondria of rat
Results
molecular target: monoamine oxidase A
Reference
Vilches-Herrera, Marcelo; Miranda-Sepulveda, Juan; Rebolledo-Fuentes, Marco; Fierro, Angelica; Luehr, Susan; IturriagaVasquez, Patricio; Cassels, Bruce K.; Reyes-Parada, Miguel
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 6 p. 2452 - 2460 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
enzyme activity; inhibition of
Species or TestSystem (Pharmacological Data)
brain mitochondria of rat
Concentration (Pharmacological Data)
100 μmol/l
Results
no effect (related to monoamine oxidase B)
Reference
Vilches-Herrera, Marcelo; Miranda-Sepulveda, Juan; Rebolledo-Fuentes, Marco; Fierro, Angelica; Luehr, Susan; IturriagaVasquez, Patricio; Cassels, Bruce K.; Reyes-Parada, Miguel
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 6 p. 2452 - 2460 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
behavioral
Species or TestSystem (Pharmacological Data)
α1G-/- transgenic mouse
Method (Pharmacological Data)
Example 2 Investigation of Behavioral Changes of Transgenic Mice Deficient in α1G T-Type Calcium Channel Investigation of Reactivity to a New Environment In order to investigate reactivity to a new environment and a strange subject of α1G calcium channel transgenic mice, the present inventors transferred them to a breeding cage and an openfield to observe their behavioral changes. First, for the analysis of behavioral aspect of a transgenic mouse in a new breeding cage, each mouse was raised dependently in a cage for 24 hours. Then, the mouse was transferred to a new cage and its behavior was recorded for 1 hour by DDC camera. A person who was not informed about its genotype observed the behavior by the recorded tape. For reactivity test in an openfield, a test animal was transferred to a test room one hour before the test began and each animal was put in an independent breeding cage for adaptation. The floor of the openfield (white acryl, 50.x.50.x.50 cm) was covered with 0.5 cm litter, on which a test animal was put and locomotor of the animal was observed for 1 hour. As a result, mobility of both a wild type α1G +/+ mouse and a transgenic α1G -/- mouse was significantly increased in an early stage while they were searching a new environment. In particular, reactivity to a new subject of a transgenic mouse was much increased, comparing to a wild type (FIGS. 1 and 2). Particularly, when a mouse was freed in an openfield, searching motility was increased for the initial 30 minutes, and when an animal was put in a new breeding cage, searching motility was increased for the early 20 minutes. However, the searching motility was no more increased after habituation in both a wild type α1G +/+ mouse and a transgenic α1G -/mouse, and no difference between the two groups was observed at last. Investigation of Reactivity to a New Subject In order to verify the result obtained in the above Example , the present inventors provided a new material in each cage to investigate reactivity. A mouse was transferred from a familiar old cage to a temporary cage to provide a new material in the old cage. Precisely, two identical subjects (size: 3.x.3.x.3 cm, weight: 2.5 g, styrofoam rolled up with paper tape) were put at 10 cm distance from the end of one side. Then, a mouse was back to the familiar cage with its head facing opposite side from the subjects. Its' behavior was observed for 15 minutes. The subjects were not fixed on the floor, suggesting they were movable. All the behavior of the test animal during the test was recorded by a video camera for further analysis. Behavioral analysis was performed by measuring the moving distance for 1 hour; a latency period until the first contact to a new subject; contact time for 15 minutes; contact frequency and pattern; and moving distance of the subject. "Contact" means when a nose of a mouse was heading toward a new subject within a 2 cm-radius or directly touching the subject. Contact patterns are classified into approaching which means a nose of the test animal is heading toward or directly touching a provided subject, digging which means the animal is digging litters around the subject with its nose heading toward the subject, pushing which means the animal moves the subject with its nose, towing which means the animal moves the subject with its forefeet and biting which means the animal
moves the subject with its mouth. After observing reactivity to a new subject, a unique behavior that has not been observed in any other so far was seen in an α1G -/- mouse. Approaching time to a new material was shorter but contact time was longer, comparing to a wild type mouse (FIG. 3C). Behavioral pattern was also unique, that is, digging around the material, biting, pulling and dragging the material, which were all hardly seen in wild type mice (FIG. 3D). In early stage, a test animal was simply hunting the new circumst Location
Page/Page column 3; 6; Sheet 8
Comment (Pharmacological Data)
No effect
Reference
Korea Institute of Science and Technology
Patent: US2008/15163 A1, 2008 ; Title/Abstract Full Text Show Details
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Effect (Pharmacological Data)
protein association; increase of
Species or TestSystem (Pharmacological Data)
HEK293 cells expressing MSR and FLAG-tagged human DAT
Concentration (Pharmacological Data)
10 μmol/l
Method (Pharmacological Data)
cells transfected with syntaxin 1A (SYN1A); treated with title comp. for 5 min at 37 deg C; lysed; DAT proteins immunoprecipitated using anti-FLAG antibody; immunoblot analysis performed for SYN1A using anti-HPC-1 antibody; DAT/SYN1A association detd.
Further Details (Pharmacological Data)
control: vehicle; MSR: macrophage scavenger receptor; DAT: dopamine transporter; HEK: human embryonic kidney
Results
title comp. increased DAT/SYN1A association but had no effect on total levels of SYN1A; amount of DAT recovered in immunoprecipitated fraction after title comp. treatment was 104percent of control; fig.
Reference
Binda, Francesca; Dipace, Concetta; Bowton, Erica; Robertson, Sabrina D.; Lute, Brandon J.; Fog, Jacob U.; Zhang, Minjia; Sen, Namita; Colbran, Roger J.; Gnegy, Margaret E.; Gether, Ulrik; Javitch, Jonathan A.; Erreger, Kevin; Galli, Aurelio
Molecular Pharmacology, 2008 , vol. 74, # 4 p. 1101 - 1108 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
protein association; increase of
Species or TestSystem (Pharmacological Data)
HEK293 cells expressing MSR and FLAG-tagged human DAT
Concentration (Pharmacological Data)
10 μmol/l
Method (Pharmacological Data)
cells transfected with syntaxin 1A (SYN1A); treated with title comp. (5 min, 37 deg C); labeled with biotin; lysed; immunoprecipitated using anti-FLAG antibody; immunoblot analysis done for SYN1A using anti-HPC-1 antibody; DAT/SYN1A association detd.
Further Details (Pharmacological Data)
control: vehicle; MSR: macrophage scavenger receptor; DAT: dopamine transporter; HEK: human embryonic kidney; further study: effect of KN93 or Ca(2+)/calmodulin-dependent protein kinase II inhibitor peptide (CaMKIINtide) on title comp. activity
Results
title comp. increased interaction between DAT and SYN1A; amount of DAT recovered in immunoprecipitated fraction after title comp. treatment was 101percent of control; KN93 and CaMKIINtide blocked title comp. activity; fig.
Reference
Binda, Francesca; Dipace, Concetta; Bowton, Erica; Robertson, Sabrina D.; Lute, Brandon J.; Fog, Jacob U.; Zhang, Minjia; Sen, Namita; Colbran, Roger J.; Gnegy, Margaret E.; Gether, Ulrik; Javitch, Jonathan A.; Erreger, Kevin; Galli, Aurelio
Molecular Pharmacology, 2008 , vol. 74, # 4 p. 1101 - 1108 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
protein association; increase of
Species or TestSystem (Pharmacological Data)
synaptosomes from striatum of mouse
Concentration (Pharmacological Data)
10 μmol/l
Method
synaptosomes treated with title comp. for 5 min at 37 deg C; lysed; lysed; DAT proteins immunoprecipitated using anti-FLAG antibody;
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(Pharmacological Data)
immunoblot analysis performed for SYN1A using anti-HPC-1 antibody; DAT/SYN1A association detd.
Further Details (Pharmacological Data)
control: vehicle; DAT: dopamine transporter; SYN1A: syntaxin 1A
Results
title comp. increased DAT/SYN1A association; amount of DAT recovered in immunoprecipitated fraction after title comp. treatment was 105percent of control; fig.
Reference
Binda, Francesca; Dipace, Concetta; Bowton, Erica; Robertson, Sabrina D.; Lute, Brandon J.; Fog, Jacob U.; Zhang, Minjia; Sen, Namita; Colbran, Roger J.; Gnegy, Margaret E.; Gether, Ulrik; Javitch, Jonathan A.; Erreger, Kevin; Galli, Aurelio
Molecular Pharmacology, 2008 , vol. 74, # 4 p. 1101 - 1108 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
protein association; increase of
Species or TestSystem (Pharmacological Data)
synaptosomes from striatum of mouse
Concentration (Pharmacological Data)
10 μmol/l
Method (Pharmacological Data)
synaptosomes treated with title comp. for 5 min at 37 deg C; labeled with biotin; lysed; DAT proteins immunoprecipitated using anti-FLAG antibody; immunoblot analysis performed for SYN1A using anti-HPC-1 antibody; DAT/SYN1A association detd.
Further Details (Pharmacological Data)
control: vehicle; DAT: dopamine transporter; SYN1A: syntaxin 1A
Results
title comp. increased interaction between DAT and SYN1A; amount of DAT recovered in immunoprecipitated fraction after title comp. treatment was 102percent of control; fig.
Reference
Binda, Francesca; Dipace, Concetta; Bowton, Erica; Robertson, Sabrina D.; Lute, Brandon J.; Fog, Jacob U.; Zhang, Minjia; Sen, Namita; Colbran, Roger J.; Gnegy, Margaret E.; Gether, Ulrik; Javitch, Jonathan A.; Erreger, Kevin; Galli, Aurelio
Molecular Pharmacology, 2008 , vol. 74, # 4 p. 1101 - 1108 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
transmitter releasing
Species or TestSystem (Pharmacological Data)
HEK293 cells expressing MSR and FLAG-tagged human DAT
Concentration (Pharmacological Data)
10 μmol/l
Method (Pharmacological Data)
cells transfected with syntaxin 1A (SYN1A); incub. with DA for 30 min at 37 deg C; placed in superfusion apparatus; perfused with title comp. for 2 min at 3-10 min; DA release quantified by HPLC
Further Details (Pharmacological Data)
control: cells transiently transfected with empty vector; DAT: dopamine (DA) transporter; HEK: human embryonic kidney
Results
title comp. stimulated DAT-mediated DA efflux; transfection of SYN1A signif. increased ability of title comp. to stimulate DA efflux with respect to vector-transfected control; fig.
Reference
Binda, Francesca; Dipace, Concetta; Bowton, Erica; Robertson, Sabrina D.; Lute, Brandon J.; Fog, Jacob U.; Zhang, Minjia; Sen, Namita; Colbran, Roger J.; Gnegy, Margaret E.; Gether, Ulrik; Javitch, Jonathan A.; Erreger, Kevin; Galli, Aurelio
Molecular Pharmacology, 2008 , vol. 74, # 4 p. 1101 - 1108 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
transmitter releasing
Species or TestSystem (Pharmacological Data)
HEK293 cells expressing MSR and FLAG-tagged human DAT
Concentration (Pharmacological Data)
10 μmol/l
Method (Pharmacological
cells transfected with syntaxin 1A (SYN1A); clamped in whole-cell patch-clamp configuration at -60 mV; perfused with DA + GST (gluthathione transferase) or GST-SYN1A; title comp. and cocaine added into bath; DA efflux detd. by ampherometric electrode e
Data)
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Further Details (Pharmacological Data)
control: without title comp.; MSR: macrophage scavenger receptor; DAT: dopamine (DA) transporter; HEK: human embryonic kidney; GST-SYN1A: GST fusion protein with soluble SYN1AδTM; further, effect of KN93 on title comp. activity studied
Results
title comp. induced DA efflux in cells perfused with GST-SYN1A but not with control GST; KN93 blocked SYN1A stimulation of title comp.induced efflux; fig.
Reference
Binda, Francesca; Dipace, Concetta; Bowton, Erica; Robertson, Sabrina D.; Lute, Brandon J.; Fog, Jacob U.; Zhang, Minjia; Sen, Namita; Colbran, Roger J.; Gnegy, Margaret E.; Gether, Ulrik; Javitch, Jonathan A.; Erreger, Kevin; Galli, Aurelio
Molecular Pharmacology, 2008 , vol. 74, # 4 p. 1101 - 1108 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
transmitter releasing
Species or TestSystem (Pharmacological Data)
midbrain dopaminergic neurons of mouse
Concentration (Pharmacological Data)
10 μmol/l
Method (Pharmacological Data)
neurons from mouse pups; clamped in whole-cell patch-clamp configuration at -60 mV; perfused with DA + GST (gluthathione transferase) or GST-SYN1A; title comp. and cocaine added into bath; DA efflux detd. by ampherometric electrode
Further Details (Pharmacological Data)
control: without title comp.; GST-SYN1A: GST fusion protein with soluble SYN1AδTM; DA: dopamine
Results
title comp. induced DA efflux in cells perfused with GST-SYN1A but not with control GST; fig.
Reference
Binda, Francesca; Dipace, Concetta; Bowton, Erica; Robertson, Sabrina D.; Lute, Brandon J.; Fog, Jacob U.; Zhang, Minjia; Sen, Namita; Colbran, Roger J.; Gnegy, Margaret E.; Gether, Ulrik; Javitch, Jonathan A.; Erreger, Kevin; Galli, Aurelio
Molecular Pharmacology, 2008 , vol. 74, # 4 p. 1101 - 1108 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
protein expression; inhibition of
Species or TestSystem (Pharmacological Data)
catecholaminergic cells (CAD)
Concentration (Pharmacological Data)
10 μmol/l
Method (Pharmacological Data)
cells stably transfected with full-length hNET or hNETΔ28-47 were treated with title comp. for 1-60 min; proteins recovered from biotinylated extracts were analyzed by Western blotting for the levels of hNET proteins
Further Details (Pharmacological Data)
hNET: human norepinephrine transporter
Results
title comp. decreased the levels of hNET proteins by ca. 50percent at 60 min both in cells transfected with full-length hNET and with hNETΔ28-47; the decrease was achieved faster in cells transfected with hNETΔ28-47
Reference
Dipace, Concetta; Sung, Uhna; Binda, Francesca; Blakely, Randy D.; Galli, Aurelio
Molecular Pharmacology, 2007 , vol. 71, # 1 p. 230 - 239 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
protein expression; inhibition of
Species or TestSystem (Pharmacological Data)
catecholaminergic cells (CAD)
Concentration (Pharmacological Data)
10 μmol/l
Method (Pharmacological Data)
cells stably transfected with hNETΔ28-47 were treated with title comp. for 1 min; proteins recovered from biotinylated extracts were analyzed by Western blotting for the levels of hNET proteins
Further Details
hNET: human norepinephrine transporter; further investigation with a calcium channel blocker, BAPTA-AM, NET antagonist and CAMKII
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(Pharmacological Data)
inhibitor
Results
title comp. rapidly reduced hNETΔ28-47 surface expression; the effect was Ca(2+)-dependent, NET and CAMKII were possibly involved
Reference
Dipace, Concetta; Sung, Uhna; Binda, Francesca; Blakely, Randy D.; Galli, Aurelio
Molecular Pharmacology, 2007 , vol. 71, # 1 p. 230 - 239 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
intracellular calcium level; increase of
Species or TestSystem (Pharmacological Data)
catecholaminergic cells (CAD)
Concentration (Pharmacological Data)
10 μmol/l
Method (Pharmacological Data)
cells stably transfected with full-length hNET or hNETΔ28-47 were incubated with 5 μM Oregon Green BAPTA-AM for 20 min at room tempetature; the effect of title comp. on intracellular calcium fluorescence was analyzed
Further Details (Pharmacological Data)
control: vehicle; hNET: human norepinephrine transporter; BAPTA-AM: 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acidacetoxymethyl ester; further investigation with a calcium channel blocker and NET inhibitor
Results
title comp. increased fluorescence within 10 s both in cells transfected with full-length hNET and with hNETΔ28-47; a stronger increase was observed in cells transfected with hNETΔ28-47; calcium channels and NET were possibly involved
Reference
Dipace, Concetta; Sung, Uhna; Binda, Francesca; Blakely, Randy D.; Galli, Aurelio
Molecular Pharmacology, 2007 , vol. 71, # 1 p. 230 - 239 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
enzyme; induction of
Species or TestSystem (Pharmacological Data)
catecholaminergic cells (CAD)
Concentration (Pharmacological Data)
10 μmol/l
Method (Pharmacological Data)
cells stably transfected with hNETΔ28-47 were incubated with title comp. for 1-10 min; the effect on CAMKII phosphorylation at Thr286 was analyzed by Western blotting
Further Details (Pharmacological Data)
control: vehicle; hNET: human norepinephrine transporter; further investigation with NET inhibitor
Results
title comp. rapidly increased the level of CAMKII phosphorylation; NET was possibly involved
Reference
Dipace, Concetta; Sung, Uhna; Binda, Francesca; Blakely, Randy D.; Galli, Aurelio
Molecular Pharmacology, 2007 , vol. 71, # 1 p. 230 - 239 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
protein interaction; induction of
Species or TestSystem (Pharmacological Data)
catecholaminergic cells (CAD)
Concentration (Pharmacological Data)
10 μmol/l
Method (Pharmacological Data)
cells cotransfected with His-hNET or His-hNETΔ28-47 and SYN1A were incubated with title comp. for 1 min; after biotinylation bound hNET proteins were immunoprecipitated with anti-His antibody, resolved on SDS-PAGE and immunoblotted for SYN1A
Further Details (Pharmacological Data)
control: vehicle; hNET: human norepinephrine transporter; SYN1A: syntaxin 1A; further investigation with CAMKII inhibitor
Results
title comp. increased hNET/SYN1A and hNETΔ28-47 interactions at plasma membrane by 130 and 191percent, resp.; no effect on intracellular interactions was observed; CAMKII possibly involved
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Reference
Dipace, Concetta; Sung, Uhna; Binda, Francesca; Blakely, Randy D.; Galli, Aurelio
Molecular Pharmacology, 2007 , vol. 71, # 1 p. 230 - 239 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
body weight; effect on
Species or TestSystem (Pharmacological Data)
rat
Route of Application
intraperitoneal
Method (Pharmacological Data)
In vivo testing for antiobesic activity The in-vivo testing for antiobesic activity of the inventive pyrazoline compounds is carried out as described in the publication of G. Colombo et al., "Appetite Suppression and Weight Loss after the Cannabinoid Antagonist SR 141716"; Life Sciences, 63 (8), 113-117, (1998). The respective part of the description is hereby incorporated by reference and forms part of the present disclosure. III. In-vivo testing for antiobesic activity The in-vivo testing for antiobesic activity was carried out as described above, whereby four different groups of 10 rats each were treated as follows:Group I: Group was treated with vehicle, namely arabic gum (5 wt.percent) in water.Group II: The second group of rats was treated with the inventive compound N-piperidinyl-5-(4-chlorophenyl)-1-(2,4dichlorophenyl)-4,5-dihydropyrazole-3-carboxamide according to Example 1. Said compound was administered intraperitoneally to the rats over a period of 14 days in a daily dosis of (10 mg/kg body weight).Group III: The third group of rats was treated with Amphetamine, an active ingredient known to reduce appetite. Said compound was administered intraperitoneally to the rats over a period of 14 days in a daily dosis of (5 mg/kg body weight). As can be seen from Figure 1 the body weight is lowered due to the administration of the inventive compound according to example 11 and this effect is also observed after the treatment is ended. Figure 2 shows the reduction of food intake due to the administration of the inventive compound according to example 11.
Results
The body weight is lowered due to the administration of the test compound; figure given
Location
Page/Page column title page; 37; 44; 51
Reference
Laboratorios del Dr. Esteve S.A.
Patent: EP1745783 A1, 2007 ; Title/Abstract Full Text Show Details
155 of 317
Effect (Pharmacological Data)
food intake; reduction of
Species or TestSystem (Pharmacological Data)
rat
Route of Application
intraperitoneal
Method (Pharmacological Data)
In vivo testing for antiobesic activity The in-vivo testing for antiobesic activity of the inventive pyrazoline compounds is carried out as described in the publication of G. Colombo et al., "Appetite Suppression and Weight Loss after the Cannabinoid Antagonist SR 141716"; Life Sciences, 63 (8), 113-117, (1998). The respective part of the description is hereby incorporated by reference and forms part of the present disclosure. III. In-vivo testing for antiobesic activity The in-vivo testing for antiobesic activity was carried out as described above, whereby four different groups of 10 rats each were treated as follows:Group I: Group was treated with vehicle, namely arabic gum (5 wt.percent) in water.Group II: The second group of rats was treated with the inventive compound N-piperidinyl-5-(4-chlorophenyl)-1-(2,4dichlorophenyl)-4,5-dihydropyrazole-3-carboxamide according to Example 1. Said compound was administered intraperitoneally to the rats over a period of 14 days in a daily dosis of (10 mg/kg body weight).Group III: The third group of rats was treated with Amphetamine, an active ingredient known to reduce appetite. Said compound was administered intraperitoneally to the rats over a period of 14 days in a daily dosis of (5 mg/kg body weight). As can be seen from Figure 1 the body weight is lowered due to the administration of the inventive compound according to example 11 and this effect is also observed after the treatment is ended. Figure 2 shows the reduction of food intake due to the administration of the inventive compound according to example 11.
Results
The reduction of food intake due to the test compound; figure given
Location
Page/Page column 37; 44; 52
Reference
Laboratorios del Dr. Esteve S.A.
Patent: EP1745783 A1, 2007 ; Title/Abstract Full Text Show Details
156 of 317
Effect (Pharmacological Data)
antiobesic activity
Species or TestSystem (Pharmacological Data)
rat
Route of Application
intraperitoneal
Method (Pharmacological Data)
III. In vivo testing for antiobesic activityThe in-vivo testing for antiobesic activity of the inventive pyrazoline compounds is carried out as described in the publication of G. Colombo et al., .Appetite Suppression and Weight Loss after the Cannabinoid Antagonist SR 141716"; Life Sciences, 63 (8), 113-117, (1998). The respective part of the description is hereby incorporated by reference and forms part of the present
disclosure.; III. In vivo testing for antiobesic activityThe in-vivo testing for antiobesic activity of the inventive pyrazoline compounds is carried out as described in the publication of G. Colombo et al., .Appetite Suppression and Weight Loss after the Cannabinoid Antagonist SR 141716"; Life Sciences, 63 (8), 113-117, (1998). The respective part of the description is hereby incorporated by reference and forms part of the present disclosure. Results
Results are given in figure 1 and 2.
Location
Page/Page column 80; 135; sheet 1, sheet 2
Reference
LABORATORIOS DEL DR. ESTEVE, S.A.
Patent: WO2007/9708 A1, 2007 ; Title/Abstract Full Text Show Details
157 of 317
Effect (Pharmacological Data)
anti-obesic activity
Species or TestSystem (Pharmacological Data)
rat
Route of Application
intraperitoneal
Method (Pharmacological Data)
In vivo testing for antiobesic activity The in-vivo testing for antiobesic activity of the inventive pyrazoline compounds is carried out as described in the publication of G. Colombo et al., "Appetite Suppression and Weight Loss after the Cannabinoid Antagonist SR 141716"; Life Sciences, 63 (8), 113-117, (1998). The respective part of the description is hereby incorporated by reference and forms part of the present disclosure.III. In-vivo testing for antiobesic activity The in-vivo testing for antiobesic activity was carried out as described above, whereby four different groups of 10 rats each were treated as follows:Group I: Group was treated with vehicle, namely arabic gum (5 wt.percent) in water.Group II: The second group of rats was treated with the inventive compound N-piperidinyl-5-(4-chlorophenyl)-1-(2,4dichlorophenyl)-4,5-dihydropyrazole-3-carboxamide according to Example 1. Said compound was administered intraperitoneally to the rats over a period of 14 days in a daily dosis of (10 mg/kg body weight).Group III: The third group of rats was treated with Amphetamine, an active ingredient known to reduce appetite. Said compound was administered intraperitoneally to the rats over a period of 14 days in a daily dosis of (5 mg/kg body weight). As can be seen from Figure 1 the body weight is lowered due to the administration of the inventive compound according to example 1 and this effect is also observed after the treatment is ended. Figure 2 shows the reduction of food intake due to the administration of the inventive compound according to example 1.
Results
title compound was administered at the dose of 5 mg/kg body weight; body weight is lowered due to the administration of the title compound; see Fig. 1
Location
Page/Page column 12; 17
Reference
LABORATORIOS DEL DR. ESTEVE, S.A.
Patent: EP1757588 A1, 2007 ; Title/Abstract Full Text Show Details
158 of 317
Effect (Pharmacological Data)
food intake; reduction of
Species or TestSystem (Pharmacological Data)
rat
Route of Application
intraperitoneal
Method (Pharmacological Data)
In vivo testing for antiobesic activity The in-vivo testing for antiobesic activity of the inventive pyrazoline compounds is carried out as described in the publication of G. Colombo et al., "Appetite Suppression and Weight Loss after the Cannabinoid Antagonist SR 141716"; Life Sciences, 63 (8), 113-117, (1998). The respective part of the description is hereby incorporated by reference and forms part of the present disclosure.III. In-vivo testing for antiobesic activity The in-vivo testing for antiobesic activity was carried out as described above, whereby four different groups of 10 rats each were treated as follows:Group I: Group was treated with vehicle, namely arabic gum (5 wt.percent) in water.Group II: The second group of rats was treated with the inventive compound N-piperidinyl-5-(4-chlorophenyl)-1-(2,4dichlorophenyl)-4,5-dihydropyrazole-3-carboxamide according to Example 1. Said compound was administered intraperitoneally to the rats over a period of 14 days in a daily dosis of (10 mg/kg body weight).Group III: The third group of rats was treated with Amphetamine, an active ingredient known to reduce appetite. Said compound was administered intraperitoneally to the rats over a period of 14 days in a daily dosis of (5 mg/kg body weight). As can be seen from Figure 1 the body weight is lowered due to the administration of the inventive compound according to example 1 and this effect is also observed after the treatment is ended. Figure 2 shows the reduction of food intake due to the administration of the inventive compound according to example 1.
Results
title compound was administered at the dose of 5 mg/kg body weight; administration of title compound resulted in the reduction of food intake; see Fig. 2
Location
Page/Page column 12; 17
Reference
LABORATORIOS DEL DR. ESTEVE, S.A.
Patent: EP1757588 A1, 2007 ; Title/Abstract Full Text Show Details
159 of 317
Effect (Pharmacological Data)
locomotor activity; stimulation of
Species or TestSystem (Pharmacological Data)
mouse
Sex
male
Route of Application
intraperitoneal
Method (Pharmacological Data)
8. EXAMPLE 3 Mice (male, 8 weeks of age; 129S6/SvEv from Taconic) were housed in groups of five for one week. Animals were injected (i.p.) with either vehicle (diluent:saline at a ratio of 3:50 v/v), or one of two doses of GR341 (1 mg/kg and 3 mg/kg). After 15 minutes, animals were injected (i.p.) either with saline or Amphetamine at 3 mg/kg. Mice were held individually without food or water for an additional 15 minutes and then placed in Plexiglas activity chambers (model ENV-520; Med Associates, St. Albans, Vt.) (43.2 cm long.x.43.2 cm wide.x.30.5 cm high) to assess locomotor activity. Mice were placed into the center of the open field, and activity was recorded for 30 minutes with subtotals for 5-minute increments. Testing was performed in darkness to minimize anxiety. As shown in FIG. 17, each dose of GR341 inhibited amphetamine-induced locomotor activity. There was no significant effect of either dose of GR341 alone on locomotor activity.; FIG. 17. Effect of GR341 on locomotor activity in the context of various doses of amphetamine.
Results
title compound induced locomotor activity; for more details see fig. 17
Location
Page/Page column 3; 6
Reference
GOUAUX, ERIC; SONG, Langzhou; XIE, Yuli; LANDRY, Donald W.
Patent: US2007/293573 A1, 2007 ; Title/Abstract Full Text Show Details
160 of 317
Effect (Pharmacological Data)
electrophysiologic current; effect on
Species or TestSystem (Pharmacological Data)
Xenopus laevis oocyte with microinjected GluR2 receptor-encoding mRNA of rat
Method (Pharmacological Data)
FIG. 16A-E. Electrophysiologic studies comparing GR341 with LY451646. A. Microamperes of current over various periods of time in a GluR2 expressing oocyte (Xenopus lacevis oocyte with microinjected rat GluR2 receptor-encoding mRNA), exposed to various concentrations (0.001 μM, 0.01 μM, 0.1 μM and 1 μM) of GR341 (formula 5). B. Microamperes of current over various periods of time in a GluR2 expressing oocyte exposed to various concentrations (0.001 μM, 0.01 μM, 0.1 μM, 1 μM and 10 μM) of LY451646. C. In an oocyte expressing GluR2, ratio of current/maximal current (I/Imax) versus concentration of GR341. D. In an oocyte expressing GluR2, ratio of current/maximal current (I/Imax) versus concentration of LY451646. E. GR341.; 7. EXAMPLE 2 Electrophysiologic studies were performed comparing GR341 (formula 5) with LY451646 in cells expressing the GluR2 receptor, with results shown in FIG. 16A-D. GR341 was observed to have an EC50 of 12.7+/-0.6 nM, and therefore was more potent than LY451646, which was observed to have an EC50 of 129.5+/-16.0 nM.
Type (Pharmacological Data)
EC50
Value of Type (Pharmacological Data)
12.7 nmol/l
Results
electrophysiologic current was reduced; I/Imax EC50 was measured; more details see fig. 16A, 16C
Location
Page/Page column 3; 6
Reference
GOUAUX, ERIC; SONG, Langzhou; XIE, Yuli; LANDRY, Donald W.
Patent: US2007/293573 A1, 2007 ; Title/Abstract Full Text Show Details
161 of 317
Effect (Pharmacological Data)
monoamine transporter; interaction with
Species or TestSystem (Pharmacological Data)
rat caudate putamen crude vesicular fraction
Method (Pharmacological Data)
vesicular fraction incubated with title comp. and 2 nmol/l <3H>DHTBZ for 4 h at 25 deg C; rapid filtration; liquid scintillation counting
Further Details (Pharmacological Data)
DHTBZ: dihydrotetrabenazine; VMAT2: vesicular monoamine transporter type 2; IC50 for title comp. inhibition of <3H>DHTBZ binding
Type (Pharmacological Data)
IC50
Value of Type (Pharmacological
> 100 μmol/l
Data)
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Reference
Partilla, John S.; Dempsey, Allison G.; Nagpal, Ameet S.; Blough, Bruce E.; Baumann, Michael H.; Rothman, Richard B.
Journal of Pharmacology and Experimental Therapeutics, 2006 , vol. 319, # 1 p. 237 - 246 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
monoamine transporter; interaction with
Species or TestSystem (Pharmacological Data)
rat caudate putamen crude vesicular fraction
Method (Pharmacological Data)
vesicular fraction incubated with title comp. and 60 nmol/l <3H>dopamine for 5 min at 25 deg C; rapid filtration; liquid scintillation counting
Further Details (Pharmacological Data)
DHTBZ: dihydrotetrabenazine; VMAT2: vesicular monoamine transporter type 2; IC50 for title comp. inhibition of <3H>dopamine uptake
Type (Pharmacological Data)
IC50
Value of Type (Pharmacological Data)
3.29 μmol/l
Reference
Partilla, John S.; Dempsey, Allison G.; Nagpal, Ameet S.; Blough, Bruce E.; Baumann, Michael H.; Rothman, Richard B.
Journal of Pharmacology and Experimental Therapeutics, 2006 , vol. 319, # 1 p. 237 - 246 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
transmitter releasing
Species or TestSystem (Pharmacological Data)
rat caudate putamen crude vesicular fraction
Method (Pharmacological Data)
vesicular fraction preloaded with 60 nmol/l <3H>tyramine for 20 min at 25 deg C, incubated with title comp. for 2 min at 25 deg C; rapid filtration; liquid scintillation counting; <3H>tyramine release evaluated
Further Details (Pharmacological Data)
EC50 and EMAX for title comp. inhibition of <3H>tyramine release
Type (Pharmacological Data)
EC50
Value of Type (Pharmacological Data)
10.5 μmol/l
Results
EMAX = 95.8 percent
Reference
Partilla, John S.; Dempsey, Allison G.; Nagpal, Ameet S.; Blough, Bruce E.; Baumann, Michael H.; Rothman, Richard B.
Journal of Pharmacology and Experimental Therapeutics, 2006 , vol. 319, # 1 p. 237 - 246 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
transmitter releasing
Species or TestSystem (Pharmacological Data)
rat caudate putamen crude vesicular fraction
Method (Pharmacological Data)
vesicular fraction preloaded with 60 nmol/l <3H>dopamine for 20 min at 25 deg C, incubated with title comp. for 10 min at 25 deg C; rapid filtration; liquid scintillation counting; <3H>dopamine release evaluated
Further Details (Pharmacological Data)
EC50 and EMAX for title comp. inhibition of <3H>dopamine release
Type (Pharmacological Data)
EC50
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Value of Type (Pharmacological Data)
4.3 μmol/l
Results
EMAX = 65.7 percent
Reference
Partilla, John S.; Dempsey, Allison G.; Nagpal, Ameet S.; Blough, Bruce E.; Baumann, Michael H.; Rothman, Richard B.
Journal of Pharmacology and Experimental Therapeutics, 2006 , vol. 319, # 1 p. 237 - 246 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
accumulation; effect on
Species or TestSystem (Pharmacological Data)
human embryonic kidney 293 cells
Concentration (Pharmacological Data)
10 μmol/l
Method (Pharmacological Data)
cells were stably transfected with WT-hDAT; treated with title comp. intracellularly (20-60 min) using whole-cell patch clamp pipette; cellular distribution of WT-hDAT measured; membrane potentials recorded; intracellular fluorescence measured
Further Details (Pharmacological Data)
WT-hDAT: wild type-human dopamine transporter; control: vehicle; further study with Zn(2+) on the effect of title comp.; intracellular fluorescence measured to quantify dopamine transporter cell surface redistribution
Results
title comp. caused WT-hDAT to traffic away from membrane and accumulate intracellularly; title comp. produced significant increase in intracellular fluorescence at times between 20 and 60 min; Zn(2+) prevented the title comp. effect; diagrams, photos
Reference
Kahlig, Kristopher M.; Lute, Brandon J.; Wei, Yuqiang; Loland, Claus J.; Gether, Ulrik; Javitch, Jonathan A.; Galli, Aurelio
Molecular Pharmacology, 2006 , vol. 70, # 2 p. 542 - 548 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
accumulation; effect on
Species or TestSystem (Pharmacological Data)
human embryonic kidney 293 cells
Concentration (Pharmacological Data)
10 μmol/l
Method (Pharmacological Data)
cells stably transfected with Y335A-hDAT; treated with title comp. intracellularly (20-60 min) using whole-cell patch clamp pipette; cellular distribution of Y335A-hDAT measured; membrane potentials recorded; intracellular fluorescence measured
Further Details (Pharmacological Data)
hDAT: human dopamine transporter; Y335A-hDAT is a transporter mutant; control: vehicle; further study with Zn(2+) on the effect of title comp.; intracellular fluorescence measured to quantify dopamine transporter cell surface redistribution
Results
title comp. failed to cause cellular redistribution of Y335A-hDAT; intracellular fluorescence unchanged by title comp.; coapplication of title comp. and Zn(2+) led to increase in Y335A-hDAT intracellular pool; diagrams, photos
Reference
Kahlig, Kristopher M.; Lute, Brandon J.; Wei, Yuqiang; Loland, Claus J.; Gether, Ulrik; Javitch, Jonathan A.; Galli, Aurelio
Molecular Pharmacology, 2006 , vol. 70, # 2 p. 542 - 548 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
transporter expression; reduction of
Species or TestSystem (Pharmacological Data)
human embryonic kidney 293 cells
Concentration (Pharmacological Data)
10 μmol/l
Method (Pharmacological Data)
cells with/without Zn(2+) were treated with title comp. intracellularly (37 deg C, 1 h); cell surface biotinylation performed; biotinylated proteins, total cell lysates separated by SDS-PAGE; immunoblotted; biotinylated band densities quantified
Further Details (Pharmacological Data)
WT-hDAT: wild type-human dopamine transporter; control: vehicle
Results
title comp. treatment induced 46percent reduction in cell surface expression of wild type-human dopamine transporter compared with
control; coincubation of title comp. with Zn(2+) prevented title comp. effect; diagrams, photos
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Reference
Kahlig, Kristopher M.; Lute, Brandon J.; Wei, Yuqiang; Loland, Claus J.; Gether, Ulrik; Javitch, Jonathan A.; Galli, Aurelio
Molecular Pharmacology, 2006 , vol. 70, # 2 p. 542 - 548 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
transporter expression; reduction of
Species or TestSystem (Pharmacological Data)
human embryonic kidney 293 cells
Concentration (Pharmacological Data)
10 μmol/l
Method (Pharmacological Data)
cells with/without Zn(2+) were treated with title comp. intracellularly (37 deg C, 1 h); cell surface biotinylation performed; biotinylated proteins, total cell lysates separated by SDS-PAGE; immunoblotted; biotinylated band densities quantified
Further Details (Pharmacological Data)
hDAT: human dopamine transporter; Y335A-hDAT is a transporter mutant; control: vehicle
Results
title comp. treatment did not reduce cell surface expression of Y335A-hDAT; coincubation with title comp. and Zn(2+) resulted in 27percent loss of cell surface Y335A-hDAT; diagram, photo
Reference
Kahlig, Kristopher M.; Lute, Brandon J.; Wei, Yuqiang; Loland, Claus J.; Gether, Ulrik; Javitch, Jonathan A.; Galli, Aurelio
Molecular Pharmacology, 2006 , vol. 70, # 2 p. 542 - 548 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
accumulation; effect on
Species or TestSystem (Pharmacological Data)
human embryonic kidney 293 cells
Concentration (Pharmacological Data)
10 μmol/l
Method (Pharmacological Data)
cells stably transfected with Y335A-hDAT were treated with title comp. intracellularly using whole-cell current-clamp pipette; after 20 min of perfusion, Y335A-hDAT intracellular fluorescence quantified using confocal imaging
Further Details (Pharmacological Data)
hDAT: human dopamine transporter; Y335A-hDAT is a transporter mutant; control: vehicle; reference: dopamine
Results
title comp. produced an increase in Y335A-hDAT intracellular fluorescence; photo, diagram
Reference
Kahlig, Kristopher M.; Lute, Brandon J.; Wei, Yuqiang; Loland, Claus J.; Gether, Ulrik; Javitch, Jonathan A.; Galli, Aurelio
Molecular Pharmacology, 2006 , vol. 70, # 2 p. 542 - 548 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
cytotoxicity
Species or TestSystem (Pharmacological Data)
PC12 cells
Kind of Dosing (Pharmacological Data)
chronic treatment with dose of 30 μM; acute dose was 1 mM
Method (Pharmacological Data)
cells cultured with non-toxic conc. of title comp. for 7-12 months and further incubated with acute dose of title comp. for 96 h; cell viability measured using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) reduction assay
Further Details (Pharmacological Data)
further investigations on dopaminergic system involvement by measurement of extra/intracellular dopamine (DA) levels and dihydroxyphenylacetic acid (DOPAC; DA metabolite) formation by HPCL; control: non-exposed to chronic title comp. cells
Results
title comp. induced the same decrease in cell viability (ca. 40percent) as control; no detectable levels of extra/intracellular DA or DOPAC were detected, indicating that DA was not involved in title comp. induced toxicity; fig.
Reference
Cunha-Oliveira, Teresa; Rego, A. Cristina; Morgadinho, Maria Teresa; Macedo, Tice; Oliveira, Catarina Resende
Toxicology, 2006 , vol. 217, # 1 p. 54 - 62 Title/Abstract Full Text View citing articles Show Details
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Effect (Pharmacological Data)
oxidative stress injury; reduction of
Species or TestSystem (Pharmacological Data)
PC12 cells
Concentration (Pharmacological Data)
30 μmol/l
Method (Pharmacological Data)
cells cultured with non-toxic conc. of title comp. for 7-12 months and further incubated with H2O2 (75 μM) for 24 h; cell viability measured using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) reduction assay
Further Details (Pharmacological Data)
control: non-exposed to title comp. cells
Results
chronic title comp. treatment slightly protected cells from acute exposure to H2O2: decrease in cell viability was ca. 70percent compared with 80percent for control; fig.
Reference
Cunha-Oliveira, Teresa; Rego, A. Cristina; Morgadinho, Maria Teresa; Macedo, Tice; Oliveira, Catarina Resende
Toxicology, 2006 , vol. 217, # 1 p. 54 - 62 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
cytotoxicity
Species or TestSystem (Pharmacological Data)
PC12 cells
Concentration (Pharmacological Data)
1 mmol/l
Method (Pharmacological Data)
cells cultured with non-toxic conc. of H2O2 for 7-12 months and further incubated with title comp. for 96 h; cell viability measured using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) reduction assay
Further Details (Pharmacological Data)
control: non-exposed to chronic H2O2 cells
Results
title comp. toxicity was similar to toxicity of control cells, suggesting that title comp. toxic effect was independent of adaptive changes induced by oxidative stress; fig.
Reference
Cunha-Oliveira, Teresa; Rego, A. Cristina; Morgadinho, Maria Teresa; Macedo, Tice; Oliveira, Catarina Resende
Toxicology, 2006 , vol. 217, # 1 p. 54 - 62 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
dopamine release; induction of
Species or TestSystem (Pharmacological Data)
PC12 cells
Concentration (Pharmacological Data)
3 mmol/l
Method (Pharmacological Data)
cells cultured with title comp. for 24 h; extra/intracellular dopamine (DA) levels and dihydroxyphenylacetic acid (DOPAC; DA metabolite) formation assessed by HPLC
Further Details (Pharmacological Data)
control: untreated cells
Results
compared to control title comp. increased extracellular DA accumulation by 5.6-fold and led to decreases in intracellular DA (by 8.3-fold); fig.
Reference
Cunha-Oliveira, Teresa; Rego, A. Cristina; Morgadinho, Maria Teresa; Macedo, Tice; Oliveira, Catarina Resende
Toxicology, 2006 , vol. 217, # 1 p. 54 - 62 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
metabolism; inhibition of
175 of 317
Species or TestSystem (Pharmacological Data)
PC12 cells
Concentration (Pharmacological Data)
3 mmol/l
Method (Pharmacological Data)
cells cultured with title comp. for 24 h; dopamine metabolite (dihydroxyphenylacetic acid) formation assessed by HPLC
Further Details (Pharmacological Data)
control: untreated cells
Results
compared to control title comp. decreased dihydroxyphenylacetic acid level by 4.7-fold; fig.
Reference
Cunha-Oliveira, Teresa; Rego, A. Cristina; Morgadinho, Maria Teresa; Macedo, Tice; Oliveira, Catarina Resende
Toxicology, 2006 , vol. 217, # 1 p. 54 - 62 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
latency of different sleep states; effect on
Species or TestSystem (Pharmacological Data)
Sprague Dawley rat
Sex
male
Route of Application
intraperitoneal
Method (Pharmacological Data)
EXAMPLE STUDY PURPOSE:This study was undertaken to determine the effect of the (D) or (R) enantiomer of a phenylalkylamino carbamate of Formula I, specifically O- carbamoyl-(D)-phenylalaninol which can also be named (R)-(beta-amino- benzenepropyl) carbamate shown above as Formula Ib, referred to herein as "TEST COMPOUND" on the sleep-wake organization in rats after acute administration of test compound, in direct comparison to amphetamine and cocaine. EPO In order to characterize the profile of activity of TEST COMPOUND in sleep-wake organization in rats, animals were chronically implanted with electrodes for recording the cortical electroencephalogram, electrical neck muscle activity, and ocular movements, while whole body movement levels were simultaneously registered. Secondly, effects were compared with those obtained with two reference psychostimulant drugs, cocaine and amphetamine. Changes in sleep-wake organization can be reliably detected on the basis of such polysomnographic recordings. Subsequent analysis of the pattern of changes has been validated to predict the class of psychotropic agents to which the compound under investigation resembles best. (See, Ruigt, GS et al. (1993) Neuropsychobiology, 28(3):138-153)MATERIALS AND METHODS AnimalsThe experiments were carried out on male adult Sprague Dawley rats, supplied by Harlan (Borchen, Germany) weighing 240-26Og at time of surgery. Animals were housed in full-view Plexiglas cages (25x33x18 cm) that fit to IVC- racks (individually ventilated cages) located in a sound attenuated chamber. Rats were provided with a micro-chip for identification purposes and maintained under controlled environmental conditions throughout the study: 22 +/- 2°C ambient temperature, relative humidity at 60percent, 12:12 light-dark cycle (lights on from 12:00 hrs to 00:00 hrs; light intensity ~100 lux) with standard laboratory food chow and tap water available ad libitum. The institutional animal care and use committee approved all animal procedures.Surgery Under isoflurane inhalation anesthesia, the rats were mounted in a stereotaxic apparatus. The oval area of the scalp was removed, and the uncovered skull was cleared of the periosteum. Three small cavities were drilled into the cranial bone without perforating the dura to receive 3 fixing stainless steel screws (diameter 1 mm) for polygraphic recording of frontal and parietal electroencephalogram (EEG). Two electrodes were placed EPO stereotaxically on each side of the sagittal suture (AP + 2 mm, L - 2 mm;and AP - 6 mm, L 3 mm from Bregma, while the third (reference) electrode was screwed over the cerebellum. The incisor bar was -5 mm under the centre of the ear bar, according to the stereotactic atlas of Paxinos G. Watson C. The Rat Brain in Stereotaxic Coordinates, Academic Press, San Diego, CA, U.S.A. (1998).For the recording of the electro-oculogram (EOG) and electromyogram (EMG), stainless steel wires were placed in peri-orbital, and inserted into nuckal muscle, respectively. Electrodes (stainless steel wire, 7N51465T5TLT, 51/46 Teflon Bilaney, Germany) were connected to a pin (Future Electronics: 0672-2-15-15-30-27-10-0) with a small insert (track pins ; Dataflex: TRP-1558-0000) were fitted into a 8 holes connector. Finally, the electrodes were fixed with dental cement to the cranium. The animals were housed individually and were allowed to recover for at least one week.Sleep Recording Procedure and Pharmacological TestTen days after surgery, the animals were habituated for two weeks to the recording procedure in their home cages. The rats were connected at regular intervals with a cable to a rotating swivel allowing free movements while EEG, EOG and EMG activities were monitored.Only rats that complied with the required criteria were used at time of testing i.e. weight of animals 300-700 g, good polygraphical signal quality, a wash out period of at least 14 days in case of subject reuse, and no failure in t
Results
Results are given in table 1.
Location
Page/Page column 33-47
Reference
JANSSEN PHARMACEUTICA, N.V; AHNAOU, Abdallah; DRINKENBURG, Wilhelmus, H.I.M.; PALUMBO, Joseph; SPORN, Jonathan
Patent: WO2006/133393 A1, 2006 ; Title/Abstract Full Text Show Details
176 of 317
Effect (Pharmacological Data)
duration of different sleep states; effect on
Species or TestSystem (Pharmacological Data)
Sprague Dawley rat
Sex
male
Route of Application
intraperitoneal
Method (Pharmacological Data)
EXAMPLE STUDY PURPOSE:This study was undertaken to determine the effect of the (D) or (R) enantiomer of a phenylalkylamino carbamate of Formula I, specifically O- carbamoyl-(D)-phenylalaninol which can also be named (R)-(beta-amino- benzenepropyl) carbamate shown above as Formula Ib, referred to herein as "TEST COMPOUND" on the sleep-wake organization in rats after acute administration of test compound, in direct comparison to amphetamine and cocaine. EPO In order to characterize the profile of activity of TEST COMPOUND in sleep-wake organization in rats, animals were chronically implanted with electrodes for recording the cortical electroencephalogram, electrical neck muscle activity, and ocular movements, while whole body movement levels were simultaneously registered. Secondly, effects were compared with those obtained with two reference psychostimulant drugs, cocaine and amphetamine. Changes in sleep-wake organization can be reliably detected on the basis of such polysomnographic recordings. Subsequent analysis of the pattern of changes has been validated to predict the class of psychotropic agents to which the compound under investigation resembles best. (See, Ruigt, GS et al. (1993) Neuropsychobiology, 28(3):138-153)MATERIALS AND METHODS AnimalsThe experiments were carried out on male adult Sprague Dawley rats, supplied by Harlan (Borchen, Germany) weighing 240-26Og at time of surgery. Animals were housed in full-view Plexiglas cages (25x33x18 cm) that fit to IVC- racks (individually ventilated cages) located in a sound attenuated chamber. Rats were provided with a micro-chip for identification purposes and maintained under controlled environmental conditions throughout the study: 22 +/- 2°C ambient temperature, relative humidity at 60percent, 12:12 light-dark cycle (lights on from 12:00 hrs to 00:00 hrs; light intensity ~100 lux) with standard laboratory food chow and tap water available ad libitum. The institutional animal care and use committee approved all animal procedures.Surgery Under isoflurane inhalation anesthesia, the rats were mounted in a stereotaxic apparatus. The oval area of the scalp was removed, and the uncovered skull was cleared of the periosteum. Three small cavities were drilled into the cranial bone without perforating the dura to receive 3 fixing stainless steel screws (diameter 1 mm) for polygraphic recording of frontal and parietal electroencephalogram (EEG). Two electrodes were placed EPO stereotaxically on each side of the sagittal suture (AP + 2 mm, L - 2 mm;and AP - 6 mm, L 3 mm from Bregma, while the third (reference) electrode was screwed over the cerebellum. The incisor bar was -5 mm under the centre of the ear bar, according to the stereotactic atlas of Paxinos G. Watson C. The Rat Brain in Stereotaxic Coordinates, Academic Press, San Diego, CA, U.S.A. (1998).For the recording of the electro-oculogram (EOG) and electromyogram (EMG), stainless steel wires were placed in peri-orbital, and inserted into nuckal muscle, respectively. Electrodes (stainless steel wire, 7N51465T5TLT, 51/46 Teflon Bilaney, Germany) were connected to a pin (Future Electronics: 0672-2-15-15-30-27-10-0) with a small insert (track pins ; Dataflex: TRP-1558-0000) were fitted into a 8 holes connector. Finally, the electrodes were fixed with dental cement to the cranium. The animals were housed individually and were allowed to recover for at least one week.Sleep Recording Procedure and Pharmacological TestTen days after surgery, the animals were habituated for two weeks to the recording procedure in their home cages. The rats were connected at regular intervals with a cable to a rotating swivel allowing free movements while EEG, EOG and EMG activities were monitored.Only rats that complied with the required criteria were used at time of testing i.e. weight of animals 300-700 g, good polygraphical signal quality, a wash out period of at least 14 days in case of subject reuse, and no failure in t
Results
Results are given in table 2.
Location
Page/Page column 33-47
Reference
JANSSEN PHARMACEUTICA, N.V; AHNAOU, Abdallah; DRINKENBURG, Wilhelmus, H.I.M.; PALUMBO, Joseph; SPORN, Jonathan
Patent: WO2006/133393 A1, 2006 ; Title/Abstract Full Text Show Details
177 of 317
Effect (Pharmacological Data)
sleep parameter; effect on
Species or TestSystem (Pharmacological Data)
Sprague Dawley rat
Sex
male
Route of Application
intraperitoneal
Method (Pharmacological Data)
EXAMPLE STUDY PURPOSE:This study was undertaken to determine the effect of the (D) or (R) enantiomer of a phenylalkylamino carbamate of Formula I, specifically O- carbamoyl-(D)-phenylalaninol which can also be named (R)-(beta-amino- benzenepropyl) carbamate shown above as Formula Ib, referred to herein as "TEST COMPOUND" on the sleep-wake organization in rats after acute administration of test compound, in direct comparison to amphetamine and cocaine. EPO In order to characterize the profile of activity of TEST COMPOUND in sleep-wake organization in rats, animals were chronically implanted with electrodes for recording the cortical electroencephalogram, electrical neck muscle activity, and ocular movements, while whole body movement levels were simultaneously registered. Secondly, effects were compared with those obtained with two reference psychostimulant drugs, cocaine and amphetamine. Changes in sleep-wake organization can be reliably detected on the basis of such polysomnographic recordings. Subsequent analysis of the pattern of changes has been validated to predict the class of psychotropic agents to which the compound under investigation resembles best. (See, Ruigt, GS et al. (1993) Neuropsychobiology, 28(3):138-153)MATERIALS AND METHODS AnimalsThe experiments were carried out on male adult Sprague Dawley rats, supplied by Harlan (Borchen, Germany) weighing 240-26Og at time of surgery. Animals were housed in full-view Plexiglas cages (25x33x18 cm) that fit to IVC- racks (individually ventilated cages) located in a sound attenuated chamber. Rats were provided with a micro-chip for identification purposes and maintained under controlled environmental conditions throughout the study: 22 +/- 2°C ambient temperature, relative humidity at 60percent, 12:12 light-dark cycle (lights on from 12:00 hrs to 00:00 hrs; light intensity ~100 lux) with standard laboratory food chow and tap water available ad libitum. The institutional animal care and use committee approved all animal procedures.Surgery Under isoflurane inhalation anesthesia, the rats were mounted in a stereotaxic apparatus. The oval area of the scalp was removed, and the uncovered skull was cleared of the periosteum. Three small cavities were drilled into the cranial bone without perforating the dura to receive 3 fixing stainless steel screws (diameter 1 mm) for polygraphic recording of frontal and parietal electroencephalogram (EEG). Two electrodes were placed EPO stereotaxically on each side of the sagittal suture (AP + 2 mm, L - 2 mm;and AP - 6 mm, L 3 mm from Bregma, while the third (reference) electrode was screwed over the cerebellum. The incisor bar was -5 mm under the centre of the ear bar, according to the stereotactic atlas of Paxinos G. Watson C. The Rat Brain in Stereotaxic Coordinates, Academic Press, San Diego, CA, U.S.A. (1998).For the recording of the electro-oculogram (EOG) and electromyogram (EMG), stainless steel wires were placed in peri-orbital, and inserted into nuckal muscle, respectively. Electrodes (stainless steel wire, 7N51465T5TLT, 51/46 Teflon Bilaney, Germany) were connected to a pin (Future Electronics: 0672-2-15-15-30-27-10-0) with a small insert (track pins ; Dataflex: TRP-1558-0000) were fitted into a 8 holes connector. Finally, the electrodes were fixed with dental cement to the cranium. The animals were housed individually and were allowed to recover for at least one week.Sleep Recording Procedure and Pharmacological TestTen days after surgery, the animals were habituated for two weeks to the recording procedure in their
home cages. The rats were connected at regular intervals with a cable to a rotating swivel allowing free movements while EEG, EOG and EMG activities were monitored.Only rats that complied with the required criteria were used at time of testing i.e. weight of animals 300-700 g, good polygraphical signal quality, a wash out period of at least 14 days in case of subject reuse, and no failure in t Results
Results are given in table 3.
Location
Page/Page column 33-47
Reference
JANSSEN PHARMACEUTICA, N.V; AHNAOU, Abdallah; DRINKENBURG, Wilhelmus, H.I.M.; PALUMBO, Joseph; SPORN, Jonathan
Patent: WO2006/133393 A1, 2006 ; Title/Abstract Full Text Show Details
178 of 317
Effect (Pharmacological Data)
number of shifts from different sleep state; effect on
Species or TestSystem (Pharmacological Data)
Sprague Dawley rat
Sex
male
Route of Application
intraperitoneal
Method (Pharmacological Data)
EXAMPLE STUDY PURPOSE:This study was undertaken to determine the effect of the (D) or (R) enantiomer of a phenylalkylamino carbamate of Formula I, specifically O- carbamoyl-(D)-phenylalaninol which can also be named (R)-(beta-amino- benzenepropyl) carbamate shown above as Formula Ib, referred to herein as "TEST COMPOUND" on the sleep-wake organization in rats after acute administration of test compound, in direct comparison to amphetamine and cocaine. EPO In order to characterize the profile of activity of TEST COMPOUND in sleep-wake organization in rats, animals were chronically implanted with electrodes for recording the cortical electroencephalogram, electrical neck muscle activity, and ocular movements, while whole body movement levels were simultaneously registered. Secondly, effects were compared with those obtained with two reference psychostimulant drugs, cocaine and amphetamine. Changes in sleep-wake organization can be reliably detected on the basis of such polysomnographic recordings. Subsequent analysis of the pattern of changes has been validated to predict the class of psychotropic agents to which the compound under investigation resembles best. (See, Ruigt, GS et al. (1993) Neuropsychobiology, 28(3):138-153)MATERIALS AND METHODS AnimalsThe experiments were carried out on male adult Sprague Dawley rats, supplied by Harlan (Borchen, Germany) weighing 240-26Og at time of surgery. Animals were housed in full-view Plexiglas cages (25x33x18 cm) that fit to IVC- racks (individually ventilated cages) located in a sound attenuated chamber. Rats were provided with a micro-chip for identification purposes and maintained under controlled environmental conditions throughout the study: 22 +/- 2°C ambient temperature, relative humidity at 60percent, 12:12 light-dark cycle (lights on from 12:00 hrs to 00:00 hrs; light intensity ~100 lux) with standard laboratory food chow and tap water available ad libitum. The institutional animal care and use committee approved all animal procedures.Surgery Under isoflurane inhalation anesthesia, the rats were mounted in a stereotaxic apparatus. The oval area of the scalp was removed, and the uncovered skull was cleared of the periosteum. Three small cavities were drilled into the cranial bone without perforating the dura to receive 3 fixing stainless steel screws (diameter 1 mm) for polygraphic recording of frontal and parietal electroencephalogram (EEG). Two electrodes were placed EPO stereotaxically on each side of the sagittal suture (AP + 2 mm, L - 2 mm;and AP - 6 mm, L 3 mm from Bregma, while the third (reference) electrode was screwed over the cerebellum. The incisor bar was -5 mm under the centre of the ear bar, according to the stereotactic atlas of Paxinos G. Watson C. The Rat Brain in Stereotaxic Coordinates, Academic Press, San Diego, CA, U.S.A. (1998).For the recording of the electro-oculogram (EOG) and electromyogram (EMG), stainless steel wires were placed in peri-orbital, and inserted into nuckal muscle, respectively. Electrodes (stainless steel wire, 7N51465T5TLT, 51/46 Teflon Bilaney, Germany) were connected to a pin (Future Electronics: 0672-2-15-15-30-27-10-0) with a small insert (track pins ; Dataflex: TRP-1558-0000) were fitted into a 8 holes connector. Finally, the electrodes were fixed with dental cement to the cranium. The animals were housed individually and were allowed to recover for at least one week.Sleep Recording Procedure and Pharmacological TestTen days after surgery, the animals were habituated for two weeks to the recording procedure in their home cages. The rats were connected at regular intervals with a cable to a rotating swivel allowing free movements while EEG, EOG and EMG activities were monitored.Only rats that complied with the required criteria were used at time of testing i.e. weight of animals 300-700 g, good polygraphical signal quality, a wash out period of at least 14 days in case of subject reuse, and no failure in t
Results
Results are given in table 4.
Location
Page/Page column 33-47
Reference
JANSSEN PHARMACEUTICA, N.V; AHNAOU, Abdallah; DRINKENBURG, Wilhelmus, H.I.M.; PALUMBO, Joseph; SPORN, Jonathan
Patent: WO2006/133393 A1, 2006 ; Title/Abstract Full Text Show Details
179 of 317
Effect (Pharmacological Data)
enzyme; inhib. of
Species or TestSystem (Pharmacological Data)
DBA/2N/Kuo mouse liver microsomes CYP2A5
Sex
male and female
Method (Pharmacological Data)
enzymatic assay; coumarin used as a substrate; in the presence of NADPH; Tris-HCl buffer, pH 7.4; 37 deg C; 10 min incubation; coumarin 7-hydroxylation monitored by fluorescence measurements
Type (Pharmacological Data)
pIC50
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181 of 317
182 of 317
Value of Type (Pharmacological Data)
2.85 dimensionless
Reference
Rahnasto, Minna; Raunio, Hannu; Poso, Antti; Wittekindt, Carsten; Juvonen, Risto O.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 2 p. 440 - 449 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
enzyme; inhib. of
Species or TestSystem (Pharmacological Data)
human liver microsomes CYP2A6
Method (Pharmacological Data)
enzymatic assay; coumarin used as a substrate; in the presence of NADPH; Tris-HCl buffer, pH 7.4; 37 deg C; 10 min incubation; coumarin 7-hydroxylation monitored by fluorescence measurements
Type (Pharmacological Data)
pIC50
Value of Type (Pharmacological Data)
3.50 dimensionless
Reference
Rahnasto, Minna; Raunio, Hannu; Poso, Antti; Wittekindt, Carsten; Juvonen, Risto O.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 2 p. 440 - 449 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
enzyme; inhib. of
Species or TestSystem (Pharmacological Data)
recombinant cytochrome P450 2C8
Concentration (Pharmacological Data)
30 μmol/l
Method (Pharmacological Data)
title comp. added to rhCYP2C8+substrate (ADQ)+NADPH mixture in phosphate buffer (pH 7.4) with MgCl2 and incubated at 37 deg C for 10 min; ADQ N-deethylase activity of rhCYP2C8 determined by measurement of N-desethylamodiaquine with HPLC/MS/MS
Further Details (Pharmacological Data)
rhCYP2C8: heterologously expressed recombinant CYP2C8; ADQ: amodiaquine
Results
title comp. inhibited enzyme by 11.2 percent
Reference
Walsky, Robert L.; Gaman, Emily A.; Obach, R. Scott
Journal of Clinical Pharmacology, 2005 , vol. 45, # 1 p. 68 - 78 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
behavioural symptoms
Species or TestSystem (Pharmacological Data)
Wistar-Kyoto rat
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
0.6 - 10 mg/kg
Method (Pharmacological Data)
after single title comp. injection, rat locomotor activity recorded in open-field cages continuously (sample time: 10 min) throughout 24 h cycle for 2 d
Further Details (Pharmacological Data)
control: saline
Results
title comp. at 0.6-2.5 mg/kg significantly dose-dependently increased locomotor activity, at 10 mg/kg had no effect on horizontal activity
but rather produced significant increase in stereotypic behavior
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Reference
Prieto-Gomez; Vazquez-Alvarez; Martinez-Pena; Reyes-Vazquez; Yang; Dafny
Life Sciences, 2005 , vol. 77, # 6 p. 635 - 649 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
synaptic currents; induction of
Species or TestSystem (Pharmacological Data)
Wister rat
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
2.5 - 20 mg/kg
Method (Pharmacological Data)
24 h after title comp. injection, rats sacrificed under anesthesia; brain removed and cut; spontaneous miniature exitatory post-synaptic currents recorded from horizontal midbrain slices using Axopatch 1D patch-clamp amplifier
Further Details (Pharmacological Data)
control: saline
Results
title comp. dose-dependently increased frequency and amplitude of miniature excitatory post-synaptic currents (figure)
Reference
Prieto-Gomez; Vazquez-Alvarez; Martinez-Pena; Reyes-Vazquez; Yang; Dafny
Life Sciences, 2005 , vol. 77, # 6 p. 635 - 649 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
synaptic currents; induction of
Species or TestSystem (Pharmacological Data)
Wister rat horisontal midbrain slice
Sex
male
Concentration (Pharmacological Data)
2.5 - 20 μmol/l
Method (Pharmacological Data)
brain slices placed in bath perfused with title comp.; spontaneous miniature exitatory post-synaptic currents recorded from brain slices comp. using Axopatch 1D patch-clamp amplifier
Further Details (Pharmacological Data)
control: saline
Results
title comp. dose-dependently increased frequency and amplitude of miniature excitatory post-synaptic currents (figure)
Reference
Prieto-Gomez; Vazquez-Alvarez; Martinez-Pena; Reyes-Vazquez; Yang; Dafny
Life Sciences, 2005 , vol. 77, # 6 p. 635 - 649 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
synaptic currents; induction of
Species or TestSystem (Pharmacological Data)
Wister rat brain slice
Sex
male
Concentration (Pharmacological Data)
2.5 - 20 μmol/l
Method (Pharmacological Data)
brain slices perfused with title comp. in bath; NMDA mediated exitatory post-synaptic currents recorded by whole-cell patch clamping from VTA-DA neurons following PFC afferent stimulation
Further Details (Pharmacological
NMDA: N-methyl-D-aspartate; VTA-DA: ventral tegmental areas dopaminergic; PFC: prefrontal cortex; control: saline
Data)
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Results
title comp. significantly increased NMDA mediated excitatory post-synaptic currents at high doses of 10.0 and 20.0 μmol/l (figure)
Reference
Prieto-Gomez; Vazquez-Alvarez; Martinez-Pena; Reyes-Vazquez; Yang; Dafny
Life Sciences, 2005 , vol. 77, # 6 p. 635 - 649 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
synaptic currents; effect on
Species or TestSystem (Pharmacological Data)
Wister rat
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
2.5 - 20 mg/kg
Method (Pharmacological Data)
24 h after title comp. injection, rats sacrificed under anesthesia; brain removed and cut; NMDA mediated exitatory post-synaptic currents recorded by whole-cell patch clamping from VTA-DA neurons following PFC afferent stimulation
Further Details (Pharmacological Data)
NMDA: N-methyl-D-aspartate; VTA-DA: ventral tegmental areas dopaminergic; PFC: prefrontal cortex; control: saline
Comment (Pharmacological Data)
No effect
Reference
Prieto-Gomez; Vazquez-Alvarez; Martinez-Pena; Reyes-Vazquez; Yang; Dafny
Life Sciences, 2005 , vol. 77, # 6 p. 635 - 649 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
synaptic currents; induction of
Species or TestSystem (Pharmacological Data)
Wister rat brain slices
Sex
male
Concentration (Pharmacological Data)
2.5 - 20 μmol/l
Method (Pharmacological Data)
brain slices perfused with title comp. in bath; AMPA mediated exitatory post-synaptic currents recorded by whole-cell patch clamping from VTA-DA neurons following PFC afferent stimulation
Further Details (Pharmacological Data)
AMPA: α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; VTA-DA: ventral tegmental areas dopaminergic; PFC: prefrontal cortex; control: saline
Results
title comp. significantly increased AMPA mediated excitatory post-synaptic currents at doses of 5.0 - 20.0 μmol/l by 14.10 - 23.71 percent, resp. (figure)
Reference
Prieto-Gomez; Vazquez-Alvarez; Martinez-Pena; Reyes-Vazquez; Yang; Dafny
Life Sciences, 2005 , vol. 77, # 6 p. 635 - 649 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
synaptic currents; induction of
Species or TestSystem (Pharmacological Data)
Wister rat
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological
2.5 - 20 mg/kg
Data)
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Method (Pharmacological Data)
24 h after title comp. injection, rats sacrificed under anesthesia; brain removed and cut; AMPA mediated exitatory post-synaptic currents recorded by whole-cell patch clamping from VTA-DA neurons following PFC afferent stimulation
Further Details (Pharmacological Data)
AMPA: α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; VTA-DA: ventral tegmental areas dopaminergic; PFC: prefrontal cortex; control: saline
Results
title comp. significantly increased AMPA mediated excitatory post-synaptic currents at doses of 10 and 20.0 mg/kg (figure)
Reference
Prieto-Gomez; Vazquez-Alvarez; Martinez-Pena; Reyes-Vazquez; Yang; Dafny
Life Sciences, 2005 , vol. 77, # 6 p. 635 - 649 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
gene expression; induction of
Species or TestSystem (Pharmacological Data)
Chinese hamster ovary cells
Concentration (Pharmacological Data)
10 μmol/l
Method (Pharmacological Data)
cells incubated with title comp. for 18 h; 1 μmol/l isoprenaline or 10 μmol/l forskolin added; reaction substrate PNPP added, incubated 1 h at 37 deg C; activity of secreted placental alkaline phosphatase (SPAP) measured spectrophotometrically
Further Details (Pharmacological Data)
cells transfected with human β2 adrenoceptor and SPAP reporter gene with multiple cAMP response elements in promoter region; PNPP: p-nitrophenol phosphate
Results
title comp. significantly potentiated isoprenaline- and forskolin-stimulated SPAP production (to 171.23 percent for isoprenaline stimulation)
Reference
Richards; Abdel-Razaq; Bates; Kendall
Biochemical Pharmacology, 2005 , vol. 70, # 5 p. 762 - 769 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
induction of hyper-locomotion
Species or TestSystem (Pharmacological Data)
rat
Method (Pharmacological Data)
In vivo test: Behaviour Behavioural activity was measured using eight Digiscan activity monitors (RXYZM (16) TAO, Omnitech Electronics, Columbus, OH, USA), connected to an Omnitech Digiscan analyzer and a Apple Macintosh computer equipped with a digital interface board (NB DIO- 24, National Instruments, USA). Each activity monitor consisted of a quadratic metal frame (WxL 40x40 cm) equipped with photobeam sensors. During measurements of behavioural activity, a rat was put in a transparent acrylic cage (WxLxH, 40x40x30 cm) which in turn was placed in the activity monitor. Each activity monitor was equipped with three rows of infrared photobeam sensors, each row consisting of 16 sensors. Two rows were placed along the front and the side of the floor of the cage, at a 90° angle, and the third row was placed 10 cm above the floor to measure vertical activity. Photobeam sensors were spaced 2.5 cm apart. Each activity monitor was fitted in an identical sound and light attenuating box containing a weak house light and a fan. The computer software was written using object oriented programming (LabVIEWNo., National instruments, Austin, TX, USA). Behavioural data from each activity monitor, representing the position (horizontal centre of gravity and vertical activity) of the animal at each time, were recorded at a sampling frequency of 25 Hz and collected using a custom written LABViewNo. application. The data from each recording session were stored and analyzed with respect to distance traveled. Each behavioural recording session lasted 60 min, starting approximately 4 min after the injection of test compound. Similar behavioural recording procedures were applied for drug-naive and drug pre-treated rats. Rats pretreated with d-amphetamine were given a dose of 1.5 mg/kg i.p.. 10 min before the recording session in the activity monitor. Rats pretreated with MK-801 were given a dose of 0.7 mg/kg i.p.. 90 min before the recording session in the activity monitor. The results are presented as counts/60 minutes, or counts/30 minutes, in arbitrary length units. Statistical comparisons were carried out using student's t-test vs the control group. In MK-801 or amphetamine pre-treated animals, statistical comparisons were made vs the MK801 or d-amphetamine controls, respectively. EDso values for reduction of amphetamine-induced hyper-locomotion are calculated by curve fitting. For most compounds, the evaluation is based on 16 amphetamine pre- treated animals over the dose range 0,11, 33 and 100 μmol/kg s. c. in one single experiment, with complementary doses in separate experiments. Calculations are based on distance during the last 45 minutes of one hour of measurement. The distances are normalised to amphetamine-control and fitted by least square minimization to the function "End-(End-Control)/(1+ (dose/ED50)Slope)". The four parameters are fitted with the restrictions: ED50>0,0.50percent of control. To estimate confidence levels for the parameters, the fit is repeated 100 times with a random evenly distributed squared weight (0 to 1) for every measurement value. Presented EDso-ranges cover 95percent of these values; Table 4. Effects of compounds in the present invention on reduction of amphetamine- induced hyper-locomotion. Comparative examples from prior art is also included. For methods and statistical calculations see the enclosed tests.
Results
The title compound was used for the induction of hyper.locomotion for testing examined compounds.
Location
Page/Page column 17; 32-33
Reference
A. CARLSSON RESEARCH AB
Patent: WO2005/121092 A1, 2005 ; Title/Abstract Full Text Show Details
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Effect (Pharmacological Data)
symptoms related to a viral infection; decrease of
Species or TestSystem (Pharmacological Data)
human
Route of Application
peroral
Method (Pharmacological Data)
EXAMPLE It has been unexpectedly determined that a person who was regularly taking ADDERALL prescribed by a doctor for ADD (Attention Deficit Disorder) exhibited symptoms related to a viral infection that included headache, runny nose, coughing. This person was associated with a variety of other individuals who also exhibited similar symptoms. The person missed some dosages of the prescribed ADDERALL. Upon ingesting the recommended dosage of the ADDERALL, the person, within one hour, experienced complete relief of the runny nose, cough, and sinus and chest congestion. However, the symptoms would reappear upon skipping the prescribed dosage of ADDERALL.
Results
Upon ingesting the recommended dosage of the title compound, the person, within one hour, experienced complete relief of the runny nose, cough, and sinus and chest congestion.
Location
Page/Page column 2
Reference
Wasson, Allan Anthony
Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details
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Effect (Pharmacological Data)
transmitter releasing
Species or TestSystem (Pharmacological Data)
rat pheochromocytoma PC12 cells
Concentration (Pharmacological Data)
1 μmol/l
Kind of Dosing (Pharmacological Data)
pretreatment with title comp. for 5 min a day during 5 d; 10 d later test dose given
Method (Pharmacological Data)
cells grown in DMEM during title comp. pretreatment; 10 d later incubation with title comp. in Krebs-Ringer bicarbonate buffer with or without 1.2 mmol/l CaCl2 for 2.5 min; dopamine (DA) in samples analysed by HPLC with electrochemical detection
Further Details (Pharmacological Data)
DMEM: Dulbecco's modified Eagle's medium; HPLC: high-pressure liquid chromatography; control: vehicle; further investigations with Ca(2+) channel blockers, tetanus toxin, reserpine, calmodulin kinase II inhibitor (KN-93), and protein kinase C inhibitor
Results
title comp. induced DA efflux from cells; this effect was Ca(2+)-dependently enhanced after title comp. pretreatment; DA efflux induction was inhibited by protein kinase C inhibitor, while Ca(2+) channel blockers and KN-93 inhibited only enhancement
Reference
Kantor; Zhang; Guptaroy; Park; Gnegy, Margaret E.
Journal of Pharmacology and Experimental Therapeutics, 2004 , vol. 311, # 3 p. 1044 - 1051 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
intracellular Ca(2+); increase of
Species or TestSystem (Pharmacological Data)
rat pheochromocytoma PC12 cells
Concentration (Pharmacological Data)
1 μmol/l
Kind of Dosing (Pharmacological Data)
pretreatment with title comp. for 5 min a day during 5 d; 10 d later test dose of title comp. given
Method (Pharmacological Data)
cells grown in DMEM during title comp. pretreatment; 10 d later cells resuspended in KRB buffer with or without 1.2 mmol/l CaCl2 and loaded with fura-2/AM; intracellular Ca(2+) measured in presence of title comp. at 37 deg C; spectrofluorometry
Further Details (Pharmacological Data)
DMEM: Dulbecco's modified Eagle's medium; AM: acetoxymethyl ester; KRB: Krebs-Ringer bicarbonate; control: vehicle; reference comp.: bradykinin (BK); further investigations with L- and N-type Ca(2+) channel blockers and desipramine (DP)
Results
title comp. Ca(2+)-independently increased cellular Ca(2+) similarly to BK; effect of title comp., but not of BK, was enhanced by title
comp. pretreatment; absence of Ca(2+) and Ca(2+) channel blockers prevented enhancement, while DP blocked all effects
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Reference
Kantor; Zhang; Guptaroy; Park; Gnegy, Margaret E.
Journal of Pharmacology and Experimental Therapeutics, 2004 , vol. 311, # 3 p. 1044 - 1051 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
enzyme; inhib. of
Species or TestSystem (Pharmacological Data)
rat pheochromocytoma PC12 cells
Concentration (Pharmacological Data)
1 μmol/l
Kind of Dosing (Pharmacological Data)
pretreatment with title comp. for 5 min a day during 5 d; 10 d later test dose of title comp. given; dissolved in saline
Method (Pharmacological Data)
cells grown in DMEM during title comp. pretreatment; 10 d later cells resuspended in KRB buffer and incubated with title comp. for 2.5 min; CaM kinase II activity measured in cell homogenate using autocamtide as a substrate and <γ-32P>ATP
Further Details (Pharmacological Data)
DMEM: Dulbecco's modified Eagle's medium; KRB: Krebs-Ringer bicarbonate; CaM: calmodulin; control: vehicle; further investigations using sulpiride
Results
title comp. inhibited CaM kinase II activity in vehicle-pretreated, but not in title comp.-pretreated cells; it was not affected by sulpiride; title comp. pretreatment caused no difference in CaM kinase activity without title comp. challenge
Reference
Kantor; Zhang; Guptaroy; Park; Gnegy, Margaret E.
Journal of Pharmacology and Experimental Therapeutics, 2004 , vol. 311, # 3 p. 1044 - 1051 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
transport
Species or TestSystem (Pharmacological Data)
rat pheochromocytoma PC12 cells
Concentration (Pharmacological Data)
1 μmol/l
Kind of Dosing (Pharmacological Data)
treatment with title comp. for 5 min a day during 5 d
Method (Pharmacological Data)
cells grown in DMEM during title comp. treatment; 10 d later cells harvested, placed in tubes, and eqilibrated at 37 deg C; uptake of 50 nmol/l or 1 μmol/l <3H>dopamine measured in Krebs-Ringer bicarbonate buffer with or without 1.2 mmol/l CaCl2
Further Details (Pharmacological Data)
DMEM: Dulbecco's modified Eagle's medium; control: vehicle
Comment (Pharmacological Data)
No effect
Reference
Kantor; Zhang; Guptaroy; Park; Gnegy, Margaret E.
Journal of Pharmacology and Experimental Therapeutics, 2004 , vol. 311, # 3 p. 1044 - 1051 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
metabolic
Species or TestSystem (Pharmacological Data)
rat pheochromocytoma PC12 cells
Concentration (Pharmacological Data)
1 μmol/l
Kind of Dosing (Pharmacological Data)
treatment with title comp. for 5 min a day during 5 d
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Method (Pharmacological Data)
cells grown in Dulbecco's modified Eagle's medium during title comp. treatment; 10 d later cellular dopamine content determined
Further Details (Pharmacological Data)
control: vehicle; further investigation using tetanus toxin and reserpine
Comment (Pharmacological Data)
No effect
Reference
Kantor; Zhang; Guptaroy; Park; Gnegy, Margaret E.
Journal of Pharmacology and Experimental Therapeutics, 2004 , vol. 311, # 3 p. 1044 - 1051 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
protease resistance; induction of
Species or TestSystem (Pharmacological Data)
Sprague-Dawley rat striatal membranes
Sex
male
Concentration (Pharmacological Data)
10 μmol/l
Method (Pharmacological Data)
membrane (DAT) incubated with title comp., followed by digestion with trypsin for 10 min at 22 deg C, then subjected to electrophoresis and immunoblotting with mAb 16
Further Details (Pharmacological Data)
mAb: monoclonal antibody; DAT: dopamine transporter; EL: extracellular loop
Comment (Pharmacological Data)
No effect
Reference
Gaffaney, Jon D.; Vaughan, Roxanne A.
Molecular Pharmacology, 2004 , vol. 65, # 3 p. 692 - 701 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
ligand binding; inhibition of
Species or TestSystem (Pharmacological Data)
Sprague-Dawley rat
Sex
male
Route of Application
subcutaneous
Concentration (Pharmacological Data)
2 - 8 mg/kg
Kind of Dosing (Pharmacological Data)
dissolved in saline
Method (Pharmacological Data)
20 min after title comp. administration <3H>raclopride was injected i.v.; 30 min later striata and cerebella were removed separately, solubilized, and counted; specific binding to D2 was estimated as the ratio of radioactivity striatum/cerebellum
Further Details (Pharmacological Data)
D2 = dopamine receptors; control: vehicle; the cerebellum was investigated to estimate the nonspecific binding
Results
title comp. decreased the specific binding of <3H>raclopride dose-dependently; the decrease was significant at 8 mg/kg title comp. (diagram)
Reference
Sun; Ginovart; Ko; Seeman; Kapur
Molecular Pharmacology, 2003 , vol. 63, # 2 p. 456 - 462 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
ligand binding; inhibition of
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Species or TestSystem (Pharmacological Data)
Sprague-Dawley rat
Sex
male
Route of Application
subcutaneous
Concentration (Pharmacological Data)
8 mg/kg
Kind of Dosing (Pharmacological Data)
dissolved in saline
Method (Pharmacological Data)
rats were sacrificed 1 - 6 h after title comp. administration; 30 min before sacrifice <3H>raclopride was injected i.v.; striata and cerebella were removed separately, solubilized, and counted
Further Details (Pharmacological Data)
specific binding to D2 was estimated as the ratio of radioactivity striatum/cerebellum; the cerebellum was investigated to estimate the nonspecific binding; D2 = dopamine receptors; control: vehicle
Results
title comp. decreased the specific binding of <3H>raclopride time-dependently; the decrease was significant at all time points (diagram)
Reference
Sun; Ginovart; Ko; Seeman; Kapur
Molecular Pharmacology, 2003 , vol. 63, # 2 p. 456 - 462 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
ligand binding; inhibition of
Species or TestSystem (Pharmacological Data)
Sprague-Dawley rat
Sex
male
Route of Application
subcutaneous
Concentration (Pharmacological Data)
8 mg/kg
Kind of Dosing (Pharmacological Data)
dissolved in saline
Method (Pharmacological Data)
rats were sacrificed 50 min after title comp. administration; membrane homogenate from one striatum side (left or right) was used for <3H>raclopride, and the other for <3H>spiperone binding assays; filter-bound radioactivity was counted
Further Details (Pharmacological Data)
dopamine D2 receptors were invest.; nonspecific binding was defined with 10 μmol/l (S)-sulpiride; control: vehicle; further invest. performed after preincubation of membranes with 200 μmol/l 5'-guanylylimidodiphosphate (GPP(NH)p) for 60 min
Results
title comp. decreased the <3H>raclopride but not <3H>spiperone binding; the effect of title comp. was caused by a decrease in D2receptor density, whereas Kd was unchanged; pretreatment with GPP(NH)p did not alter the effect of title comp. (tables)
Reference
Sun; Ginovart; Ko; Seeman; Kapur
Molecular Pharmacology, 2003 , vol. 63, # 2 p. 456 - 462 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
ligand binding; inhibition of
Species or TestSystem (Pharmacological Data)
Sprague-Dawley rat
Sex
male
Route of Application
subcutaneous
Concentration (Pharmacological Data)
8 mg/kg
Kind of Dosing
dissolved in saline
(Pharmacological Data)
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Method (Pharmacological Data)
rats were sacrificed 50 min after title comp. administration; striata were homogenized and fractioned by centrifugation; fractions were assayed for <3H>raclopride or <3H>spiperone specific binding; filter-bound radioactivity was counted
Further Details (Pharmacological Data)
dopamine D2 receptors were invest.; nonspecific binding was defined with 10 μmol/l (S)-sulpiride; control: vehicle
Results
treatment with title comp. significantly reduced the binding of <3H>raclopride in the total homogenate, the nuclear, and the mitochondrial fractions, whereas <3H>spiperone binding was only reduced in the mitochondrial fraction (diagram)
Reference
Sun; Ginovart; Ko; Seeman; Kapur
Molecular Pharmacology, 2003 , vol. 63, # 2 p. 456 - 462 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
ligand binding; inhibition of
Species or TestSystem (Pharmacological Data)
Sprague-Dawley rat
Sex
male
Route of Application
subcutaneous
Concentration (Pharmacological Data)
8 mg/kg
Kind of Dosing (Pharmacological Data)
dissolved in saline
Method (Pharmacological Data)
rats were sacrificed 50 min after title comp. administration; striatum membrane homogenates were used for competition binding study of 2 nmol/l <3H>raclopride in the presence 1E-12 - 1E-3 mol/l dopamine; room temp.; filter-bound radioactivity counted
Further Details (Pharmacological Data)
dopamine D2 receptors were investigated; control: vehicle
Results
treatment with title comp. caused a loss of high-affinity state D2 receptors (conc.-binding curve)
Reference
Sun; Ginovart; Ko; Seeman; Kapur
Molecular Pharmacology, 2003 , vol. 63, # 2 p. 456 - 462 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
cytotoxicity
Species or TestSystem (Pharmacological Data)
rat hepatoma-derived Fa32 cells
Kind of Dosing (Pharmacological Data)
applied as sulphate via complete culture medium
Method (Pharmacological Data)
cultured in Dulbecco's modified Eagle's medium; cells treated 24 h after seeding in microtitre plate (adhered cells) or immediately after seeding (adhering cells); cytotoxicity det. through inhibition of neutral red uptake
Further Details (Pharmacological Data)
control - culture medium; NI50 - 50 percent neutral red uptake inhibition
Type (Pharmacological Data)
NI50
Value of Type (Pharmacological Data)
1.23 - 1.66 mmol/l
Results
NI50 for adhered cells was 1.66 mmol/l; for adhering cells was 1.23 mmol/l
Reference
Dierickx, Paul J.; Scheers, Ellen M.
Journal of Applied Toxicology, 2002 , vol. 22, # 1 p. 61 - 65 Title/Abstract Full Text View citing articles Show Details
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Effect (Pharmacological Data)
transmitter releasing
Species or TestSystem (Pharmacological Data)
PC12 cells
Concentration (Pharmacological Data)
1 μmol/l
Kind of Dosing (Pharmacological Data)
daily, for 5 min
Method (Pharmacological Data)
cells treated with title comp. for 5 days, followed by 10 drug-free days; cells washed; challenged with amphetamine (AMP, 0.2-100 μmol/l, 2.5-min bolus); dopamine eluted; dopamine levels measured by high pressure liguid chromatography
Further Details (Pharmacological Data)
further investigation in presence of nerve growth factor and challenge with 1 μmol/l AMP; vehicle control; Ka: kinetic constant
Results
repeated, intermittent treatment with title comp. elicited increase in Vmax (ca. 2-fold vs. control) for AMP-mediated dopamine release without change in Ka; effect was not changed in presence of nerve growth factor (figures)
Reference
Kantor, Lana; Park, Yang Hae; Wang, Kevin K.W; Gnegy, Margaret E
European Journal of Pharmacology, 2002 , vol. 451, # 1 p. 27 - 35 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
transmitter releasing
Species or TestSystem (Pharmacological Data)
human neuroblastoma SH-SY5Y cells
Concentration (Pharmacological Data)
1 μmol/l
Kind of Dosing (Pharmacological Data)
daily, for 5 min
Method (Pharmacological Data)
cells treated with title comp. for 5 days, followed by 10 drug-free days; cells washed; challenged with amphetamine (AMP, 1 μmol/l, 2.5min bolus); dopamine eluted; dopamine levels measured by high pressure liguid chromatography
Further Details (Pharmacological Data)
vehicle control
Results
repeated, intermittent treatment with title comp. elicited increase in AMP-mediated dopamine release by 32-fold vs. 17-fold increase in control (figure)
Reference
Kantor, Lana; Park, Yang Hae; Wang, Kevin K.W; Gnegy, Margaret E
European Journal of Pharmacology, 2002 , vol. 451, # 1 p. 27 - 35 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
transmitter releasing
Species or TestSystem (Pharmacological Data)
PC12 cells
Concentration (Pharmacological Data)
1 μmol/l
Kind of Dosing (Pharmacological Data)
daily, for 5 min
Method (Pharmacological Data)
cells treated with title comp. for 5 days, followed by 0-10 drug-free days; cells washed; challenged with amphetamine (AMP, 1 μmol/l, 2.5-min bolus); dopamine eluted; dopamine levels measured by high pressure liguid chromatography
Further Details (Pharmacological Data)
vehicle control
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Results
repeated, intermittent treatment with title comp. elicited increase in AMP-mediated dopamine release after 6 days of withdrawal and significantly increased after 10 days of withdrawal (figure)
Reference
Kantor, Lana; Park, Yang Hae; Wang, Kevin K.W; Gnegy, Margaret E
European Journal of Pharmacology, 2002 , vol. 451, # 1 p. 27 - 35 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
transmitter releasing
Species or TestSystem (Pharmacological Data)
PC12 cells
Concentration (Pharmacological Data)
1 μmol/l
Kind of Dosing (Pharmacological Data)
continuously present in media
Method (Pharmacological Data)
cells treated with title comp. for 5 days, followed by 10 drug-free days; washed; challenged with amphetamine (1 μmol/l, 2.5-min bolus); dopamine eluted; dopamine levels measured by high pressure liguid chromatography
Further Details (Pharmacological Data)
vehicle control
Comment (Pharmacological Data)
No effect
Reference
Kantor, Lana; Park, Yang Hae; Wang, Kevin K.W; Gnegy, Margaret E
European Journal of Pharmacology, 2002 , vol. 451, # 1 p. 27 - 35 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
uptake; effect on
Species or TestSystem (Pharmacological Data)
PC12 cells
Concentration (Pharmacological Data)
1 μmol/l
Kind of Dosing (Pharmacological Data)
daily, for 5 min
Method (Pharmacological Data)
cells treated with title comp. for 5 days, followed by 10 drug-free days; specific dopamine uptake measured with 70 nmol/l and 1 μmol/l <3H>dopamine at 1 min using nisoxetin (100 nmol/l); filter-bound radioactivity measured by scintillation counter
Further Details (Pharmacological Data)
vehicle control
Comment (Pharmacological Data)
No effect
Reference
Kantor, Lana; Park, Yang Hae; Wang, Kevin K.W; Gnegy, Margaret E
European Journal of Pharmacology, 2002 , vol. 451, # 1 p. 27 - 35 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
uptake; effect on
Species or TestSystem (Pharmacological Data)
human neuroblastoma SH-SY5Y cells
Concentration (Pharmacological Data)
1 μmol/l
Kind of Dosing
daily, for 5 min
(Pharmacological Data)
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Method (Pharmacological Data)
cells treated with title comp. for 5 days, followed by 10 drug-free days; specific dopamine uptake measured with 70 nmol/l and 1 μmol/l <3H>dopamine at 1 min using nisoxetin (100 nmol/l); filter-bound radioactivity measured by scintillation counter
Further Details (Pharmacological Data)
vehicle control
Comment (Pharmacological Data)
No effect
Reference
Kantor, Lana; Park, Yang Hae; Wang, Kevin K.W; Gnegy, Margaret E
European Journal of Pharmacology, 2002 , vol. 451, # 1 p. 27 - 35 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
gene expression; effect on
Species or TestSystem (Pharmacological Data)
PC12 cells
Concentration (Pharmacological Data)
1 μmol/l
Kind of Dosing (Pharmacological Data)
daily, for 5 min
Method (Pharmacological Data)
cells treated with title comp. for 5 days, followed by 10 drug-free days; cells lysates analyzed for norepinephrine transporter density by immunoblotting
Further Details (Pharmacological Data)
vehicle control
Comment (Pharmacological Data)
No effect
Reference
Kantor, Lana; Park, Yang Hae; Wang, Kevin K.W; Gnegy, Margaret E
European Journal of Pharmacology, 2002 , vol. 451, # 1 p. 27 - 35 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
gene expression; effect on
Species or TestSystem (Pharmacological Data)
PC12 cells
Kind of Dosing (Pharmacological Data)
daily, for 5 min
Method (Pharmacological Data)
cells treated with title comp. for 5 days, followed by 10 drug-free days; cells lysates analyzed for dopamine transporter density by immunoblotting
Further Details (Pharmacological Data)
vehicle control
Comment (Pharmacological Data)
No effect
Reference
Kantor, Lana; Park, Yang Hae; Wang, Kevin K.W; Gnegy, Margaret E
European Journal of Pharmacology, 2002 , vol. 451, # 1 p. 27 - 35 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
gene expression; effect on
Species or TestSystem
PC12 cells
(Pharmacological Data)
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Concentration (Pharmacological Data)
1 μmol/l
Method (Pharmacological Data)
cells pretreated with title comp., incubated with 10 μmol/l cocaine for 10 min; <3H>nisoxetine at 30 nmol/l added to whole cells for 30 min; expression of norepinephrine transporter as filter-bound radioactivity counted using scintillation counter
Further Details (Pharmacological Data)
vehicle control
Comment (Pharmacological Data)
No effect
Reference
Kantor, Lana; Park, Yang Hae; Wang, Kevin K.W; Gnegy, Margaret E
European Journal of Pharmacology, 2002 , vol. 451, # 1 p. 27 - 35 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
free radical generation; induction of
Species or TestSystem (Pharmacological Data)
polymorphonuclear leukocytes
Concentration (Pharmacological Data)
50 μmol/l
Method (Pharmacological Data)
leukocytes incubated with 0.01 mol/l lucigenin in polystyrene vial; chemiluminescence was read for one min; title comp. or PMA (50 nmol/l) added; measurement of chemiluminescence was repeated in 25 min at 37 deg C with a luminometer
Further Details (Pharmacological Data)
control: vehicle; PMA: phorbol myristate acetate; PMA was used to test the functional viability of the isolated polymorphonuclear leukocytes
Results
title comp. signif. enhanced the chemiluminescence generation by 152 percent as compared with its baseline value; combination of title comp. with PMA increased chemiluminescence by 360 percent; fig.
Reference
Huang, Kun-Lun; Shaw, Kai-Ping; Wang, David; Hsu, Kang; Huang, Tze-Shung; Chen, Hsing-I
Life Sciences, 2002 , vol. 71, # 11 p. 1237 - 1244 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
pneumotoxicity
Species or TestSystem (Pharmacological Data)
SD rats lung
Sex
male
Concentration (Pharmacological Data)
10 - 50 μmol/l
Method (Pharmacological Data)
isolated lung equillibrated in physiological salt soln., 10 min; title comp. added to perfusate; pulmonary arterial pressure and lung weight (LW) monitored continuously for 60 min; filteration coefficient (Kf) measured gravimetrically
Further Details (Pharmacological Data)
control: without title comp.; further effects of dimethylthiourea (DMTU) on title comp. studied
Results
title comp. induced pulmonary hypertension dose-dependently; causes signif. gain in LW; increased Kf by 90, 210 percent at 10, 50 μmol/l, resp.; title comp. induced hypertension and LW gain were attenuated and completely abolished, resp. by DMTU; diagrams
Reference
Huang, Kun-Lun; Shaw, Kai-Ping; Wang, David; Hsu, Kang; Huang, Tze-Shung; Chen, Hsing-I
Life Sciences, 2002 , vol. 71, # 11 p. 1237 - 1244 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
neuroregulatoric
Endpoint of Effect (Pharmacological Data)
DA extracellular concentration
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Species or TestSystem (Pharmacological Data)
Long-Evans rat
Sex
male and female
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
1 mg/kg
Kind of Dosing (Pharmacological Data)
applied as sulfate; in artificial cerebrospinal fluid (CSF); single injection
Method (Pharmacological Data)
Pb- or Na-exposed rats were placed in a stereotaxic frame; transversal dialysis probe was inserted into NAC of anesthetised rats; samples were collected every 20 min for 120 min after title comp. injection; HPLC
Further Details (Pharmacological Data)
nucleus accumbens (NAC); rats were continuously exposed to Pb (350 ppm) or Na (350 ppm) acetates in drinking water from early gestational day (2-6; "in utero") or from 28 days ("adult") of age; rats were used in the study at the 13th week of age
Results
title comp. induced dopamine release in NAC of rats; rats treated with Pb "in utero" responded with a lower dopamine release than rats treated "in utero" with Na; no sign. differences in the groups of rats treated "adult" were obs.; graphic represent.
Reference
Devoto, Paola; Flore, Giovanna; Ibba, Antonio; Fratta, Walter; Pani, Luca
Toxicology Letters, 2001 , vol. 121, # 3 p. 199 - 206 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
hypertensive
Species or TestSystem (Pharmacological Data)
Sprague-Dawley rat
Sex
male
Route of Application
intravenous
Concentration (Pharmacological Data)
2 mg/kg
Method (Pharmacological Data)
302 animals (253-352 g); 12/12 h light/dark cycle; food and water ad libitum; blood pressure
Comment (Pharmacological Data)
No effect
Reference
Chang; Pan; Lin
British Journal of Pharmacology, 2001 , vol. 132, # 7 p. 1524 - 1530 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
hypertensive
Species or TestSystem (Pharmacological Data)
Sprague-Dawley rat
Sex
male
Route of Application
intracutaneous
Concentration (Pharmacological Data)
0.1 - 0.3 mg
Method (Pharmacological Data)
302 animals (253-352 g); 12/12 h light/dark cycle; food and water ad libitum; blood pressure
Results
concentration dependent increase in mean arterial pressure; at 0.3 mg increase of 39 mmHg
Reference
Chang; Pan; Lin
British Journal of Pharmacology, 2001 , vol. 132, # 7 p. 1524 - 1530 Title/Abstract Full Text View citing articles Show Details
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Effect (Pharmacological Data)
antagonist
Species or TestSystem (Pharmacological Data)
Sprague-Dawley rat
Sex
male
Route of Application
intracutaneous
Concentration (Pharmacological Data)
0.1 mg
Method (Pharmacological Data)
302 animals (253-352 g); 12/12 h light/dark cycle, food and water ad libitum; the animals started receive sodium nitro-prusside (0.01-0.1 mg, i.c.) 1 h after treatment with title comp.; blood pressure
Results
title comp. attenuated the sodium nitro-prusside-induced decrease in mean arterial pressure
Reference
Chang; Pan; Lin
British Journal of Pharmacology, 2001 , vol. 132, # 7 p. 1524 - 1530 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
antagonist
Species or TestSystem (Pharmacological Data)
Sprague-Dawley rat
Sex
male
Route of Application
intracutaneous
Concentration (Pharmacological Data)
0.1 mg
Method (Pharmacological Data)
302 animals (253-352 g); 12/12 h light/dark cycle, food and water ad libitum; the animals started receive 8-Br-cyclic GMP (0.05 mg, i.c.) 1 h after treatment with title comp.; blood pressure
Results
title comp. attenuated the 8-Br-cGMP-induced decrease in mean arterial pressure
Reference
Chang; Pan; Lin
British Journal of Pharmacology, 2001 , vol. 132, # 7 p. 1524 - 1530 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
antagonist
Species or TestSystem (Pharmacological Data)
Sprague-Dawley rat
Sex
male
Route of Application
intracutaneous
Concentration (Pharmacological Data)
0.1 mg
Method (Pharmacological Data)
302 animals (253-352 g); 12/12 h light/dark cycle, food and water ad libitum; the animals started receive hydroxylamine (0.01-0.1 mg, i.c.) 1 h after treatment with title comp.; blood pressure
Results
title comp. attenuated the hydroxylamine-induced decrease in mean arterial pressure
Reference
Chang; Pan; Lin
British Journal of Pharmacology, 2001 , vol. 132, # 7 p. 1524 - 1530 Title/Abstract Full Text View citing articles Show Details
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Effect (Pharmacological Data)
behavioural symptoms
Species or TestSystem (Pharmacological Data)
Swiss albino mouse
Sex
male
Route of Application
intracerebroventricular
Concentration (Pharmacological Data)
2 μg
Kind of Dosing (Pharmacological Data)
given into cerebral ventricle, in volume of 5 μl; dissolved in isotonic saline (0.9percent NaCl)
Method (Pharmacological Data)
motor coordination evaluated by rota-rod test (16 r.p.m.) starting 15 min after title comp. treatment; number of falls from rod in 30 s recorded for up to 60 min post-treatment
Further Details (Pharmacological Data)
control: saline
Results
number of falls increased from 2.4 (before treatment) to 3.1, 3.3 and 2.7 at 15, 30 and 45 min after treatment, resp.
Reference
Pirisino; Ghelardini; Banchelli; Galeotti; Raimondi
British Journal of Pharmacology, 2001 , vol. 134, # 4 p. 880 - 886 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
anorectic
Species or TestSystem (Pharmacological Data)
Swiss albino mouse
Sex
male
Route of Application
intracerebroventricular
Concentration (Pharmacological Data)
Ca. 2 μg
Kind of Dosing (Pharmacological Data)
given into cerebral ventricle, in volume of 5 μl; dissolved in isotonic saline (0.9percent NaCl); used as sulphate
Method (Pharmacological Data)
mice starved for 12 h, food consumption measured up to 60 min after title comp. treatment
Further Details (Pharmacological Data)
control: saline
Results
title comp. reduced food consumption from 677 to 247 mg/mouse
Reference
Pirisino; Ghelardini; Banchelli; Galeotti; Raimondi
British Journal of Pharmacology, 2001 , vol. 134, # 4 p. 880 - 886 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
receptor; binding activity
Species or TestSystem (Pharmacological Data)
NIH-3T3 cell membranes expressing rat 5-HT2A receptors
Kind of Dosing (Pharmacological Data)
as sulfate
Method (Pharmacological Data)
in vitro; radioligand competition binding assay; 0.5 nmol/l <3H>ketanserin used as radioligand; binding buffer, pH 7.4; 37 deg C; incubated for 30 min; liquid scintillation counting; nonspecific binding determined using 10 μmol/l ketanserin
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Type (Pharmacological Data)
Ki
Value of Type (Pharmacological Data)
> 10000 nmol/l
Reference
Dowd; Herrick-Davis; Egan; DuPre; Smith; Teitler; Glennon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 3074 - 3084 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
receptor; binding activity
Species or TestSystem (Pharmacological Data)
A-9 cell membranes expressing rat 5-HT2C receptors
Kind of Dosing (Pharmacological Data)
as sulfate
Method (Pharmacological Data)
in vitro; radioligand competition binding assay; 2.0 nmol/l <3H>mesulegrine used as radioligand; binding buffer, pH 7.4; 37 deg C; incubated for 30 min; liquid scintillation counting; nonspecific binding determined using 1 μmol/l mesulegrine
Type (Pharmacological Data)
Ki
Value of Type (Pharmacological Data)
> 10000 nmol/l
Reference
Dowd; Herrick-Davis; Egan; DuPre; Smith; Teitler; Glennon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 3074 - 3084 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
neuroregulatoric
Species or TestSystem (Pharmacological Data)
Wistar rat
Sex
male
Route of Application
intracerebral
Concentration (Pharmacological Data)
1 - 1000 μmol/l
Kind of Dosing (Pharmacological Data)
dissolved in ACF
Method (Pharmacological Data)
title comp. perfused via microdialysis probe (reversed microdialysis) into different subregions of prefrontal cortex for 60 min; norepinephrine, serotonin, choline, acetylcholine conc. in dialysate determined by chromatography before and after perfusion
Further Details (Pharmacological Data)
anaesthetized rats; medial prefrontal subregions: dorsal prelimbic/anterior cingulate cortex and ventral prelimbic/infralimbic cortex; ACF: artificial cerebrospinal fluid
Results
title comp. produced dose-dependent increase in choline, norepinephrine, serotonin levels in both anterior cingulate and infralimbic cortices; acetylcholine level was increased in dose-dependent manner in infralimbic but not in anterior cingulate cortex
Reference
Hedou, Gael; Homberg, Judith; Martin, Sonsoles; Wirth, Katja; Feldon, Joram; Heidbreder, Christian A.
European Journal of Pharmacology, 2000 , vol. 390, # 1-2 p. 127 - 136 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
behavioural symptoms
Species or TestSystem (Pharmacological Data)
Swiss A mice
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Sex
female
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
5 mg/kg
Exposure Period (Pharmacological Data)
30 min
Method (Pharmacological Data)
in vivo; 10 mice, 18-22 g; head-dip test; 30 min after treatment with title comp. mice were placed singly on a wooden board with 16 evenly spaced holes; No. of times the head was dipped into the holes during 3 min was counted
Further Details (Pharmacological Data)
control: physiological saline
Comment (Pharmacological Data)
No effect
Reference
Pal, Siddhartha; Sen; Chaudhuri, A.K. Nag
Journal of Pharmacy and Pharmacology, 1999 , vol. 51, # 3 p. 313 - 318 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
biotransformation
Endpoint of Effect (Pharmacological Data)
metabolite formation, Vmax
Species or TestSystem (Pharmacological Data)
human CYP2D6 microsomal product
Concentration (Pharmacological Data)
30.18 nmol/l
Kind of Dosing (Pharmacological Data)
CYP2D6: 0.5 mg/incubation
Method (Pharmacological Data)
CYP2D6 isozyme isolated from a transfected human AHH-1 TK+/- cell line; incubation with title comp. at 37 deg C, pH 7.4 for 2 h with NADPH-generating system; metabolites were quantified after acetylation by GC
Results
single 4-hydroxylated metabolite; rate of metabolite formation: 0.16 nmol/h/mg protein
Metabolite (Pharmacological Data)
HO-NBA [Reaxys RN: 3264229]
Reference
Bach, Mimi V.; Coutts; Baker
Xenobiotica, 1999 , vol. 29, # 7 p. 719 - 732 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
effect on neurochemical response
Species or TestSystem (Pharmacological Data)
Sprague-Dawley rat
Sex
male
Concentration (Pharmacological Data)
2.5 - 4 mg/kg
Method (Pharmacological Data)
microdialysis rats (325-350 g) received title comp.
Further Details (Pharmacological Data)
extracellular serotonin (5-HT) response in caudate-putamen (CP) and nucleus accumbens (NA)
Results
title comp. promoted pronounced changes in extracellular levels of 5-HT in CP or NA; graphical representation
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Reference
Segal, David S.; Kuczenski, Ronald
Journal of Pharmacology and Experimental Therapeutics, 1999 , vol. 291, # 1 p. 19 - 30 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
transport; inhibition of
Species or TestSystem (Pharmacological Data)
HEK cells expressing human dopamine transporter
Method (Pharmacological Data)
cells were pre-incubated with title comp. for 10 min before addition of <3H>DA; then incubated for 10 min; filtered; radioactivity remaining on the filter was measured by liquid scintillation counting
Further Details (Pharmacological Data)
DA: dopamine; <3H>DA was used as radiolabel; non-specific uptake was defined in presence of mazindol; Krebs-HEPES buffer; 25 deg C, water bath
Type (Pharmacological Data)
IC50
Value of Type (Pharmacological Data)
29.3 nmol/l
Reference
Cashman, John R.; Xiong, Yeng N.; Lifen, Xu; Janowsky, Aaron
Journal of Pharmacology and Experimental Therapeutics, 1999 , vol. 288, # 3 p. 1251 - 1260 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
transport; inhibition of
Species or TestSystem (Pharmacological Data)
HEK cells expressing human norepinephrine transporter
Method (Pharmacological Data)
cells were pre-incubated with title comp. for 10 min before addition of <3H>NE; then incubated for 10 min; filtered; radioactivity remaining on the filter was measured by liquid scintillation counting
Further Details (Pharmacological Data)
NE: norepinephrine; <3H>NE was used as radiolabel; non-specific uptake was defined in presence of mazindol; Krebs-HEPES buffer; 25 deg C, water bath
Type (Pharmacological Data)
IC50
Value of Type (Pharmacological Data)
26.3 nmol/l
Reference
Cashman, John R.; Xiong, Yeng N.; Lifen, Xu; Janowsky, Aaron
Journal of Pharmacology and Experimental Therapeutics, 1999 , vol. 288, # 3 p. 1251 - 1260 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
transport; inhibition of
Species or TestSystem (Pharmacological Data)
HEK cells expressing human serotonin transporter
Method (Pharmacological Data)
cells were pre-incubated with title comp. for 10 min before addition of <3H>5-HT; then incubated for 10 min; filtered; radioactivity remaining on the filter was measured by liquid scintillation counting
Further Details (Pharmacological Data)
<3H>5-HT: <3H>5-hydroxytryptamine was used as radiolabel; non-specific uptake was defined in presence of imipramine; Krebs-HEPES buffer; 25 deg C, water bath
Type (Pharmacological Data)
IC50
Value of Type (Pharmacological Data)
1867 nmol/l
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Reference
Cashman, John R.; Xiong, Yeng N.; Lifen, Xu; Janowsky, Aaron
Journal of Pharmacology and Experimental Therapeutics, 1999 , vol. 288, # 3 p. 1251 - 1260 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
transport; inhibition of
Species or TestSystem (Pharmacological Data)
C6 glioma cells expressing human dopamine transporter
Method (Pharmacological Data)
cells were pre-incubated with <3H>MPP(1+) for 20 min; room temp.; washed; pre-incubated with release buffer for 10 min before title comp. was added; 37 deg C; radioactivity remaining in the cells was measured by liquid scintillation spectrometry
Further Details (Pharmacological Data)
<3H>MPP(1+): <3H>1-methyl-4-phenylpyridinium was used as radiolabel; non-specific uptake was defined in presence of mazindol; Krebs-HEPES buffer, pH 7.4; release was stimulated with trichloroacetic acid
Type (Pharmacological Data)
IC50
Value of Type (Pharmacological Data)
153 nmol/l
Reference
Cashman, John R.; Xiong, Yeng N.; Lifen, Xu; Janowsky, Aaron
Journal of Pharmacology and Experimental Therapeutics, 1999 , vol. 288, # 3 p. 1251 - 1260 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
transport; inhibition of
Species or TestSystem (Pharmacological Data)
C6 glioma cells expressing human serotonin transporter
Method (Pharmacological Data)
cells were pre-incubated with <3H>MPP(1+) for 20 min; room temp.; washed; pre-incubated with release buffer for 10 min before title comp. was added; 37 deg C; radioactivity remaining in the cells was measured by liquid scintillation spectrometry
Further Details (Pharmacological Data)
<3H>MPP(1+): <3H>1-methyl-4-phenylpyridinium was used as radiolabel; non-specific uptake was defined in presence of mazindol; Krebs-HEPES buffer, pH 7.4; release was stimulated with trichloroacetic acid
Type (Pharmacological Data)
IC50
Value of Type (Pharmacological Data)
224.2 nmol/l
Reference
Cashman, John R.; Xiong, Yeng N.; Lifen, Xu; Janowsky, Aaron
Journal of Pharmacology and Experimental Therapeutics, 1999 , vol. 288, # 3 p. 1251 - 1260 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
receptor blocking agent
Species or TestSystem (Pharmacological Data)
HEK cell membranes expressing human dopamine transporter
Method (Pharmacological Data)
radioligand binding assay; membranes were isolated; preincubated with title comp. for 10 min before addition of <125I>RTI-55; incubated for 90 min; filtered; radioactivity remaining on the filter was measured by liquid scintillation counting
Further Details (Pharmacological Data)
non-specific binding was defined in presence of mazindol; Krebs-HEPES buffer, room temp., darkness
Type (Pharmacological Data)
Ki
Value of Type (Pharmacological Data)
572000 nmol/l
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Reference
Cashman, John R.; Xiong, Yeng N.; Lifen, Xu; Janowsky, Aaron
Journal of Pharmacology and Experimental Therapeutics, 1999 , vol. 288, # 3 p. 1251 - 1260 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
receptor blocking agent
Species or TestSystem (Pharmacological Data)
HEK cell membranes expressing human serotonin transporter
Method (Pharmacological Data)
radioligand binding assay; membranes were isolated; preincubated with title comp. for 10 min before addition of <125I>RTI-55; incubated for 90 min; filtered; radioactivity remaining on the filter was measured by liquid scintillation counting
Further Details (Pharmacological Data)
non-specific binding was defined in presence of imipramine; Krebs-HEPES buffer, room temp., darkness
Type (Pharmacological Data)
Ki
Value of Type (Pharmacological Data)
37700 nmol/l
Reference
Cashman, John R.; Xiong, Yeng N.; Lifen, Xu; Janowsky, Aaron
Journal of Pharmacology and Experimental Therapeutics, 1999 , vol. 288, # 3 p. 1251 - 1260 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
receptor blocking agent
Species or TestSystem (Pharmacological Data)
HEK cell membranes expressing human NET
Method (Pharmacological Data)
radioligand binding assay; membranes were isolated; preincubated with title comp. for 10 min before addition of <125I>RTI-55; incubated for 90 min; filtered; radioactivity remaining on the filter was measured by liquid scintillation counting
Further Details (Pharmacological Data)
non-specific binding was defined in presence of mazindol; Krebs-HEPES buffer, room temp., darkness; NET: norepinephrine transporter
Type (Pharmacological Data)
Ki
Value of Type (Pharmacological Data)
926 nmol/l
Reference
Cashman, John R.; Xiong, Yeng N.; Lifen, Xu; Janowsky, Aaron
Journal of Pharmacology and Experimental Therapeutics, 1999 , vol. 288, # 3 p. 1251 - 1260 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
pharmacokinetics
Species or TestSystem (Pharmacological Data)
Homo sapiens
Concentration (Pharmacological Data)
1.25 - 10 mg
Method (Pharmacological Data)
pharmacokinetics of two dosage bioavailability of drug determining; a 1.25 mg Zydis dosage form and a 10 mg Movergan tablets
Results
mean AUC: 56.4 nM/h for Zydis dosage form; 698.7 nM/h for Movergan tablets
Reference
Seager
Journal of Pharmacy and Pharmacology, 1998 , vol. 50, # 4 p. 375 - 382 Title/Abstract Full Text View citing articles Show Details
Effect
toxicity, acute
(Pharmacological Data)
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Species or TestSystem (Pharmacological Data)
mice
Route of Application
intraperitoneal
Type (Pharmacological Data)
LD50
Value of Type (Pharmacological Data)
300 mg/kg
Reference
Morozov; Klimova; Lavrova; Avdyunina; Pyatin; Troitskaya; Bykov
Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 1 p. 1 - 4 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
anticatalepsic
Species or TestSystem (Pharmacological Data)
white mongrel rat
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
5 mg/kg
Kind of Dosing (Pharmacological Data)
in form of aqueous solutions or finely dispersed suspensions with Tween-80 (0.04 percent)
Method (Pharmacological Data)
5 animals; 180-200 g body weight; triftazin-induced catalepsy; triftazin (at a dose of 2 mg/kg) was introduced 30 min before observation; control
Further Details (Pharmacological Data)
reference compound; at the dose producing maximum specific effect; administered 1 h before observation
Reference
Morozov; Klimova; Lavrova; Avdyunina; Pyatin; Troitskaya; Bykov
Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 1 p. 1 - 4 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
psychostimulant
Endpoint of Effect (Pharmacological Data)
spontaneous motor activity
Species or TestSystem (Pharmacological Data)
white mongrel mice
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
5 mg/kg
Kind of Dosing (Pharmacological Data)
in form of aqueous solutions or finely dispersed suspensions with Tween-80 (0.04 percent)
Method (Pharmacological Data)
15-20 animals; 18-22 g body weight; placed into individual compartments; number of horizontal movements during a 15 min time interval; control
Further Details
reference compound; at the dose producing maximum specific effect; administered 1 h before experiment
(Pharmacological Data)
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Results
significant effect
Reference
Morozov; Klimova; Lavrova; Avdyunina; Pyatin; Troitskaya; Bykov
Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 1 p. 1 - 4 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
psychostimulant
Endpoint of Effect (Pharmacological Data)
working capacity
Species or TestSystem (Pharmacological Data)
white mongrel mice
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
5 mg/kg
Kind of Dosing (Pharmacological Data)
in form of aqueous solutions or finely dispersed suspensions with Tween-80 (0.04 percent)
Method (Pharmacological Data)
20-30 animals; 18-22 g body weight; loaded with 10 percent of the body weight; duration of swimming to complete fatigue in water at 27 deg C; control
Further Details (Pharmacological Data)
reference compound; at the dose producing maximum specific effect; administered 1 h before experiment
Results
pronounced stimulating effect
Reference
Morozov; Klimova; Lavrova; Avdyunina; Pyatin; Troitskaya; Bykov
Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 1 p. 1 - 4 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
psychomotor activation
Species or TestSystem (Pharmacological Data)
Sprague Dawley rats
Sex
male
Route of Application
intravenous
Concentration (Pharmacological Data)
0.125 - 8.0 mg/kg/day
Exposure Period (Pharmacological Data)
5 d
Method (Pharmacological Data)
rats (200-225 g) cannulated (dural surface); 5 days habituation, title compd. administering; two groups: home and novel; rotational behavior data collection (5 min intervals, 2 h periods)
Further Details (Pharmacological Data)
home group: animals transported to testing room; novel group: animals housed in main animal colony (excludind 2 h experimental periods)
Results
lower doses are necessary to induce sensitization in novel group; dose- and time-dependent rotational behavior evaluated (diagrams)
Reference
Browman; Badiani; Robinson
Journal of Pharmacology and Experimental Therapeutics, 1998 , vol. 287, # 3 p. 1007 - 1014 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
peristaltic stimulant
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Species or TestSystem (Pharmacological Data)
Sprague-Dawley rat
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
1 mg/kg
Kind of Dosing (Pharmacological Data)
once daily for 10 days
Method (Pharmacological Data)
rats received gastric intubation of Na2<51>CrO4 and 10 percent charcoal; 15 min later rats killed; radioactivity of stomach and each small intestine segment measured by liquid scintillation counting
Results
title comp. inhibited gastric emptying (49.3 versus 66.1 percent in control)
Reference
Doong, Ming-Luen; Lu, Chien-Chen; Kau, Mei-Mei; Tsai, Shiow-Chwen; Chiao, Yu-Chung; Chen, Jiann-Jong; Yeh, Jiun-Yih; Lin, Ho; Huang, Seng-Wong; Chen, Tseng-Shing; Chang, Full-Young; Wang, Paulus S.
British Journal of Pharmacology, 1998 , vol. 124, # 6 p. 1123 - 1130 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
releasing hormones
Species or TestSystem (Pharmacological Data)
Sprague-Dawley rat
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
0.75 - 3 mg/kg
Method (Pharmacological Data)
45 min after title comp. treatment blood samples collected; CCK concentration measured by RIA
Further Details (Pharmacological Data)
CCK: cholecystokinin
Results
3.0 mg/kg title comp. significantly increased plasma CCK level from 46.8 to 57.6 pg/ml
Reference
Doong, Ming-Luen; Lu, Chien-Chen; Kau, Mei-Mei; Tsai, Shiow-Chwen; Chiao, Yu-Chung; Chen, Jiann-Jong; Yeh, Jiun-Yih; Lin, Ho; Huang, Seng-Wong; Chen, Tseng-Shing; Chang, Full-Young; Wang, Paulus S.
British Journal of Pharmacology, 1998 , vol. 124, # 6 p. 1123 - 1130 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
peristaltic stimulant
Species or TestSystem (Pharmacological Data)
Sprague-Dawley rat
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
0.75 - 3 mg/kg
Method (Pharmacological Data)
title comp. given 30 min before gastric intubation of Na2<51>CrO4 and 10 percent charcoal; 15 min later rats killed; radioactivity of stomach and each small intestine segment measured by liquid scintillation counting
Results
title comp. dose-dependently inhibited gastric emptying (31.3, 26.4 and 20.2 percent at 0.75, 1.5 and 3.0 mg/kg, respectively (control: 67.2 percent)) and intestinal transit (3.0 mg/kg significantly reduced geometric center)
Reference
Doong, Ming-Luen; Lu, Chien-Chen; Kau, Mei-Mei; Tsai, Shiow-Chwen; Chiao, Yu-Chung; Chen, Jiann-Jong; Yeh, Jiun-Yih;
Lin, Ho; Huang, Seng-Wong; Chen, Tseng-Shing; Chang, Full-Young; Wang, Paulus S.
British Journal of Pharmacology, 1998 , vol. 124, # 6 p. 1123 - 1130 Title/Abstract Full Text View citing articles Show Details
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Comment (Pharmacological Data)
miscellaneous activity (test, effect, animals, dose, in vivo): kaluresis, 140percent variation of Na(1+) or K(1+) excretion expressed as meq/100 g body weight, rats, 20 mg/kg, p.o.
Reference
Sparatore; Novelli
Farmaco, 1997 , vol. 52, # 8-9 p. 509 - 521 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
effect on EEG in rats (Mahalanobis' distances)
Reference
Mazurov, Anatoly A.; Andronati, Sergei A.; Korotenko, Tamara I.; Sokolenko, Nikolai I.; Dyadenko, Alexei I.; Shapiro, Yury E.; Gorbatyuk, Vitalii Ya.; Voronina, Tatyana A.
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 11 p. 2029 - 2040 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
drug dependence
Species or TestSystem (Pharmacological Data)
humans
Sex
male and female
Method (Pharmacological Data)
simple experimental epidemiologic survey of prescription forgeries in community pharmacies (1253 pharmacies) in the Midi-Pyrenees area (southwest France)
Results
12.7 percent of the all forged prescription was made to obtain title compound with phenobarbitone
Reference
Lapeyre-Mestre; Damase-Michel; Adams; Michaud; Montastruc
European Journal of Clinical Pharmacology, 1997 , vol. 52, # 1 p. 37 - 39 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
enzyme; inhib. of
Species or TestSystem (Pharmacological Data)
IIBCE rat brain mitochondrial monoamine oxidase B
Sex
male
Concentration (Pharmacological Data)
0.01 - 100 μmol/l
Kind of Dosing (Pharmacological Data)
in distilled water
Method (Pharmacological Data)
MAO-B activity determined by HPLC with electrochemical detection after incubation with selective substrate of DMAPEA in presence of title comp. at 37 deg C for 5 min, pH 7.4; DMAPEA and its MAO-B metabolite DMAPAA used to calculate MAO-B activity
Further Details (Pharmacological Data)
MAO-B = monoamine oxidase B; DMAPEA = 4-dimethylaminophenethylamine, 5 μmol/l; DMAPAA = 4-dimethylaminophenylacetic acid
Comment (Pharmacological Data)
No effect
Reference
Scorza, Ma. Cecilia; Carrau, Cecilia; Silveira, Rodolfo; Zapata-Torres, Gerald; Cassels, Bruce K.; Reyes-Parada, Miguel
Biochemical Pharmacology, 1997 , vol. 54, # 12 p. 1361 - 1369 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
enzyme; inhib. of
Species or TestSystem (Pharmacological Data)
IIBCE rat brain mitochondrial monoamine oxidase A
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Sex
male
Concentration (Pharmacological Data)
0.01 - 100 μmol/l
Kind of Dosing (Pharmacological Data)
in distilled water
Method (Pharmacological Data)
MAO-A activity determined by HPLC with electrochemical detection after incubation with selective substrate of 5-HT in presence of title comp. at 37 deg C for 10 min, pH 7.4; 5-HT and its MAO-A metabolite 5-HIAA used to calculate MAO-A activity
Further Details (Pharmacological Data)
MAO-A = monoamine oxidase A; 5-HT = serotonin, 2.5 μmol/l; 5-HIAA = 5-hydroxyindoleacetic acid
Type (Pharmacological Data)
IC50
Value of Type (Pharmacological Data)
11 μmol/l
Reference
Scorza, Ma. Cecilia; Carrau, Cecilia; Silveira, Rodolfo; Zapata-Torres, Gerald; Cassels, Bruce K.; Reyes-Parada, Miguel
Biochemical Pharmacology, 1997 , vol. 54, # 12 p. 1361 - 1369 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
behavioural symptoms
Species or TestSystem (Pharmacological Data)
Sprague-Dawley rat
Sex
male
Route of Application
subcutaneous
Concentration (Pharmacological Data)
2.5 - 4 mg/kg
Method (Pharmacological Data)
15 SDI in 3 cycles (5 d title comp., 2 d saline), d 20: single dose challenge, d 21: saline, from d 22: 3 run cycles (dose every 2 h, 4 inj. per d for 5 d, then 2 d saline); 2 d after 3 cycle single dose challenge; behaviour monitored by computer, tapin
Reference
Segal, David S.; Kuczenski, Ronald
Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 282, # 2 p. 561 - 573 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
transmitter release; inhibition of
Species or TestSystem (Pharmacological Data)
Sprague-Dawley rat
Sex
male
Route of Application
subcutaneous
Concentration (Pharmacological Data)
4 mg/kg
Kind of Dosing (Pharmacological Data)
title comp. used as sulfate, dissolved in saline, administered at 2 ml/kg
Method (Pharmacological Data)
6 SDI, 48 h after the last injection followed by a run cycle (dose every 2 h, 4 inj. per d for 5 d, then 2 d saline); dialysis probes inserted into caudate-putamen and nucleus accumbens; dialysate samples collected every 30 min, analyzed by HPLC
Further Details (Pharmacological Data)
SDI: single dose injection; saline control; dialysate samples assayed for DA (dopamine), 3,4-dihydroxyphenylacetic acid, homovanillic acid, 3-methoxytyramine, 5-hydroxyindoleacetic acid, 5-HT
Results
title comp. produced a decline in caudate but not nucleus accumbens microdialysate dopamine response; serotonin response decline was insignificant (diagrams)
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Reference
Segal, David S.; Kuczenski, Ronald
Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 282, # 2 p. 561 - 573 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
pharmacokinetics
Species or TestSystem (Pharmacological Data)
rat
Route of Application
subcutaneous
Concentration (Pharmacological Data)
8 mg/kg
Kind of Dosing (Pharmacological Data)
title comp. dissolved in saline, injected in a volume of 1ml/kg
Method (Pharmacological Data)
dialysis probes inserted in caudate-putamen; title comp. given on the next day; dialysate samples collected every 10 or 20 min, assayed for title comp. level by HPLC
Further Details (Pharmacological Data)
kel, kapp: rate constant of elimination and appearance, respectively
Half-life Time (Pharmacological Data)
Ca. 45 min
Results
Tmax = 30.5 min; kel = 0.015 min-1; kapp = 0.042 min-1
Reference
Kuczenski, Ronald; Melega, William P.; Cho, Arthur K.; Segal, David S.
Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 282, # 2 p. 591 - 596 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
transmitter releasing
Species or TestSystem (Pharmacological Data)
rat
Route of Application
subcutaneous
Concentration (Pharmacological Data)
8 mg/kg
Kind of Dosing (Pharmacological Data)
title comp. dissolved in saline, injected in a volume of 1ml/kg
Method (Pharmacological Data)
dialysis probes inserted in caudate-putamen; title comp. given on the next day; dialysate samples collected every 10 or 20 min, assayed for DA, DOPAC, homovanillic acid, 3MT, 5-hydroxyindoleacetic acid by HPLC
Further Details (Pharmacological Data)
DA: dopamine, DOPAC: 3,4-dihydroxyphenylacetic acid, 3MT: 3-methoxytyramine
Results
after title comp. administration, dialysate DA level achieved max. at about 30 min, then gradually declined (diagram, table)
Reference
Kuczenski, Ronald; Melega, William P.; Cho, Arthur K.; Segal, David S.
Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 282, # 2 p. 591 - 596 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
pharmacokinetics
Species or TestSystem (Pharmacological Data)
rat
Route of Application
subcutaneous
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Concentration (Pharmacological Data)
8 mg/kg
Kind of Dosing (Pharmacological Data)
title comp. dissolved in saline, injected in a volume of 1ml/kg
Method (Pharmacological Data)
title comp. given, and caudate-putamen samples collected 5, 10, 20, 30, 60, 120, 240 min later; caudate-putamen homogenate extract assayed for title comp. level by gas chromatography/mass spectrometry
Further Details (Pharmacological Data)
kel, kapp: rate constant of elimination and appearance, respectively
Results
Tmax = 22.4 min; kel = 0.015 min-1; kapp = 0.101 min-1
Reference
Kuczenski, Ronald; Melega, William P.; Cho, Arthur K.; Segal, David S.
Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 282, # 2 p. 591 - 596 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
behavioural symptoms
Species or TestSystem (Pharmacological Data)
rat
Route of Application
subcutaneous
Concentration (Pharmacological Data)
8 mg/kg
Kind of Dosing (Pharmacological Data)
title comp. dissolved in saline, injected in a volume of 1ml/kg
Method (Pharmacological Data)
dialysis probes inserted in caudate-putamen; title comp. given on the next day; behaviour monitored by videotaping up to 3 h
Results
title comp. evoked multiphasic locomotor response that included prolonged period of intense focused stereotypies: licking, biting; max. effect at 60 min, duration up to 3 h (diagram)
Reference
Kuczenski, Ronald; Melega, William P.; Cho, Arthur K.; Segal, David S.
Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 282, # 2 p. 591 - 596 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
incorporation into hair
Species or TestSystem (Pharmacological Data)
Dark-Agouti rats
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
5 mg/kg
Exposure Period (Pharmacological Data)
10 d
Method (Pharmacological Data)
rats of 95-105 g, 5 wks old; back hair of rats shaved; hair collected; blood collected 5, 15, 30, 60, 120, 360 min after dosing; plasma prepared; areas under conc. vs. time curve (AUCs) calculated; incorporated rates (ICRs) determination
Results
AUC, 181.6 μg*min/ml; 18.05 ng/mg conc. in hair; ICR, 0.10
Reference
Nakahara, Yuji; Kikura, Ruri
Archives of Toxicology, 1996 , vol. 70, # 12 p. 841 - 849 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological
drug interaction
Data)
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Species or TestSystem (Pharmacological Data)
testes of Sprague-Dawley rats
Concentration (Pharmacological Data)
1E-11 - 1E-06 mol/l
Method (Pharmacological Data)
in vitro; pieces of rat testes preincubated in Locke solution (90 min); administration of title comp. for 1 h; radioimmunoassay of testosterone after incubation with 3-isobutyl-1-methylxanthine for 1 h
Further Details (Pharmacological Data)
in combination with humanchorionic gonadotropin (0.5 iu/ml)
Type (Pharmacological Data)
testosterone content
Value of Type (Pharmacological Data)
97.32 - 136.48 pg mg-1 h-1
Results
decrease of AMP content relatively to human chorionic gonadotropin alone
Reference
Tsai, Shiow-Chwen; Chiao, Yu-Chung; Lu, Chien-Chen; Doong, Ming-Luen; Chen, Yen-Hao; Shih, Hsi-Chang; Liaw, Charlie; Wang, Shyi-Wu; Wang, Paulus S.
British Journal of Pharmacology, 1996 , vol. 118, # 4 p. 984 - 988 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
drug interaction
Species or TestSystem (Pharmacological Data)
testes of Sprague-Dawley rats
Concentration (Pharmacological Data)
1E-08 - 1E-06 mol/l
Method (Pharmacological Data)
in vitro; pieces of rat testes preincubated in Locke solution (90 min); administration of title comp. for 1 h; radioimmunoassay of cyclic AMP after incubation with 3-isobutyl-1-methylxanthine for 1 h
Further Details (Pharmacological Data)
in combination with human chorionic gonadotropin (5 iu/ml)
Type (Pharmacological Data)
cyclic AMP content
Value of Type (Pharmacological Data)
46.64 - 50.42 fmol/mg protein/h
Results
increase of AMP content relatively to value for human chorionic gonadotropin alone
Reference
Tsai, Shiow-Chwen; Chiao, Yu-Chung; Lu, Chien-Chen; Doong, Ming-Luen; Chen, Yen-Hao; Shih, Hsi-Chang; Liaw, Charlie; Wang, Shyi-Wu; Wang, Paulus S.
British Journal of Pharmacology, 1996 , vol. 118, # 4 p. 984 - 988 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
releasing hormones
Species or TestSystem (Pharmacological Data)
testes of Sprague-Dawley rats
Concentration (Pharmacological Data)
1E-09 - 1E-06 mol/l
Method (Pharmacological Data)
in vitro; pieces of rat testes preincubated in Locke solution (90 min); administration of title comp. for 1 h; radioimmunoassay of testosterone after incubation with 3-isobutyl-1-methylxanthine for 1 h
Type
testosterone content
(Pharmacological Data)
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Value of Type (Pharmacological Data)
14710 - 22690 ng/kg
Results
increase of AMP content relatively to basal value of 38.31 pg/(mg*h)
Reference
Tsai, Shiow-Chwen; Chiao, Yu-Chung; Lu, Chien-Chen; Doong, Ming-Luen; Chen, Yen-Hao; Shih, Hsi-Chang; Liaw, Charlie; Wang, Shyi-Wu; Wang, Paulus S.
British Journal of Pharmacology, 1996 , vol. 118, # 4 p. 984 - 988 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
accumulation of cyclic AMP
Species or TestSystem (Pharmacological Data)
testes of Sprague-Dawley rats
Concentration (Pharmacological Data)
1E-09 - 1E-06 mol/l
Method (Pharmacological Data)
in vitro; pieces of rat testes preincubated in Locke solution (90 min); administration of title comp. for 1 h; radioimmunoassay of cyclic AMP after incubation with 3-isobutyl-1-methylxanthine for 1 h
Type (Pharmacological Data)
cyclic AMP content
Value of Type (Pharmacological Data)
13.38 - 16.47 fmol/(mg*h*protein)
Results
increase of AMP content relatively to basal value
Reference
Tsai, Shiow-Chwen; Chiao, Yu-Chung; Lu, Chien-Chen; Doong, Ming-Luen; Chen, Yen-Hao; Shih, Hsi-Chang; Liaw, Charlie; Wang, Shyi-Wu; Wang, Paulus S.
British Journal of Pharmacology, 1996 , vol. 118, # 4 p. 984 - 988 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
releasing hormones
Species or TestSystem (Pharmacological Data)
Sprague-Dawley rats
Sex
male
Route of Application
intravenous
Concentration (Pharmacological Data)
0.4 μg ml-1 kg-1
Method (Pharmacological Data)
rat weight 300-350 g, catheterized via right jugular vein; administration of title comp. after 20 h; sampling blood at 0, 15, 30, 60, 120, 180, 360, 480 and 1440 min; radioimmunoassay of testosterone and luteinizing hormone
Type (Pharmacological Data)
testosterone in blood plasma
Value of Type (Pharmacological Data)
0.05 - 0.22 μg/l
Results
time-dependent decrease of testosterone level (minimal after 180 min, then increase to basal value); no significant effect on basal level of luteinizing hormone
Reference
Tsai, Shiow-Chwen; Chiao, Yu-Chung; Lu, Chien-Chen; Doong, Ming-Luen; Chen, Yen-Hao; Shih, Hsi-Chang; Liaw, Charlie; Wang, Shyi-Wu; Wang, Paulus S.
British Journal of Pharmacology, 1996 , vol. 118, # 4 p. 984 - 988 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
drug interaction
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Species or TestSystem (Pharmacological Data)
Sprague-Dawley rats
Sex
male
Route of Application
intravenous
Concentration (Pharmacological Data)
0.4 μg ml-1 kg-1
Method (Pharmacological Data)
rat weight 300-350 g, catheterized via right jugular vein; administration of title comp. after 20 h; sampling blood at 0, 15, 30, 60, 120, 180, 360, 480 and 1440 min; radioimmunoassay of testosterone and luteinizing hormone
Further Details (Pharmacological Data)
in combination with human chorionic gonadotropin (5 iu/(ml*kg))
Type (Pharmacological Data)
testosterone in blood plasma
Value of Type (Pharmacological Data)
0.26 μg/l
Results
time-dependent decrease of testosterone level compared to human chorionic gonadotropin alone
Reference
Tsai, Shiow-Chwen; Chiao, Yu-Chung; Lu, Chien-Chen; Doong, Ming-Luen; Chen, Yen-Hao; Shih, Hsi-Chang; Liaw, Charlie; Wang, Shyi-Wu; Wang, Paulus S.
British Journal of Pharmacology, 1996 , vol. 118, # 4 p. 984 - 988 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
behavioural symptoms
Species or TestSystem (Pharmacological Data)
Wistar rat
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
3 mg/kg
Kind of Dosing (Pharmacological Data)
single dose
Method (Pharmacological Data)
8 rats 250-300 g; cage with white, central grey, and black chamber; day 1: chamber preference monitoring, 15 min; day 2: after title comp. administration the animal was placed in black or white chamber for 20 min; day 3: chamber preference monitoring
Further Details (Pharmacological Data)
day 1: animals introduced to grey chamber; day 3: animals introduced to grey chamber; preference is expressed as time spent in this chamber; controls were administered saline
Results
rats showed twofold higher preference for title comp.-paired chamber in comparison with controls
Reference
Zurita, Alejandra; Muru, Sergio; Molina, Victor
European Journal of Pharmacology, 1996 , vol. 299, # 1-3 p. 1 - 7 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
behavioural symptoms
Species or TestSystem (Pharmacological Data)
Wistar rat
Sex
male
Route of Application
intraperitoneal
Concentration
1.56 mg/kg
(Pharmacological Data)
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Kind of Dosing (Pharmacological Data)
single dose just before testing
Method (Pharmacological Data)
animal weight 400-590 g; 6-hydroxydopamine (16 μg/4 μl) injected into left nigra; one week recovery; animal with electro-mechanical transducer placed in Perspex bowl (diam. 40 cm); count registered when animal turned through 36 degrees both directions
Further Details (Pharmacological Data)
stereotaxic coordinates for 6-hydroxydopamine injection: AP 1.9, L 1.8, AP -2.1; counts accumulated 120 min
Results
title comp. induced more than 60 ipsiversive rotations of animals in 60 min
Reference
Eblen, Frank; Loeschmann, Peter-Andreas; Wuellner, Ullrich; Turski, Lechoslaw; Klockgether, Thomas
European Journal of Pharmacology, 1996 , vol. 299, # 1-3 p. 9 - 16 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
dopaminergic
Species or TestSystem (Pharmacological Data)
Wistar rat
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
1.75 mg/kg
Method (Pharmacological Data)
rat weight 250-275 g; 7 low and 7 high sugar feeders; 7 d adaptation period then 1 ml/kg i.p. saline injection; cannulation 2 mm dorsal to posterior-medial nucleus accumbens; aCSF perfusion; title comp. treatment; samples collected every 20 min; HPLC-EC
Further Details (Pharmacological Data)
dopamine (DA) concentration analysis; DA concentration - time curve in low and high sugar feeders; aCSF = artificial cerebrospinal fluid
Results
title comp. immediately increased DA concentration (peaked at 40 min and slowly diminished over 3 h test session) both low and high sugar feeders (diagrams given); sugar consumption correlated with title comp.-stimulated accumbens-DA overflow
Reference
Sills, Terrence L.; Crawley, Jacqueline N.
European Journal of Pharmacology, 1996 , vol. 303, # 3 p. 177 - 181 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
behavioural symptoms
Species or TestSystem (Pharmacological Data)
Wistar rat
Sex
female
Route of Application
subcutaneous
Concentration (Pharmacological Data)
0.5 mg/kg
Method (Pharmacological Data)
in vivo; rats (181-262 g) trained for immobility; title comp. or saline injected; behaviour investigated
Results
relative to saline title comp. decreased immobility (figure)
Reference
Maes, J. H. Roald; Van Rijn, Clementina M.; Vossen, Jo M. H.
European Journal of Pharmacology, 1996 , vol. 309, # 2 p. 131 - 140 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
agonist
Species or TestSystem
Sprague-Dawley rat
(Pharmacological Data)
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Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
2 mg/kg
Kind of Dosing (Pharmacological Data)
dose in 0.9 percent saline
Method (Pharmacological Data)
rat weight 350-400 g; 4 animals/group; bipolar electrode implantation into lateral hypothalamus; after 8-10 d title comp. injection; 10 training self-stimulation sessions for 13 h (50 to 100 μA)
Further Details (Pharmacological Data)
lever-pressing behaviour analysis; time - response curve
Results
title comp. produced marked facilitation of self-stimulation with peak effect seen 2 h after injection (diagram given)
Reference
Olds, Marianne E.
European Journal of Pharmacology, 1996 , vol. 306, # 1-3 p. 23 - 32 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
drug interaction
Species or TestSystem (Pharmacological Data)
Sprague-Dawley rat
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
2 mg/kg
Kind of Dosing (Pharmacological Data)
dose in 0.9 percent saline
Method (Pharmacological Data)
rat weight 350-400 g; 4 animals/group; bipolar electrode implantation into lateral hypothalamus; after 8-10 d title comp. plus 0.1 mg/kg i.p. MK-801 injection; 10 training self-stimulation sessions for 13 h (50 to 100 μA)
Further Details (Pharmacological Data)
lever-pressing behaviour analysis; time - response curve
Results
title comp. plus MK-801 resulted greater and longer-lasting facilitation than increase in responding produced by either drug alone (diagram given)
Reference
Olds, Marianne E.
European Journal of Pharmacology, 1996 , vol. 306, # 1-3 p. 23 - 32 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
effect on spontaneous motor activity in albino Swiss mice of either sexes at the dose of 5 mg/kg p.o., 60 and 120 min after administration, variations of spontaneous motility are 19.09percent and 76.88percent, resp.
Reference
Vega; Soledad Gil; Darias; Sanchez Mateo; Exposito
Pharmazie, 1995 , vol. 50, # 1 p. 27 - 33 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
anxiolytic action, albino Swiss mice of either sexes, 5 mg/kg p.o., plus-maze and holeboard test; anticonvulsant activity in the pentetrazole (120 mg/kg i.p.) and strychnine sulphate (2.5 mg/kg i.p.) seizures, albino Swiss mice of either sexes
Reference
Vega; Soledad Gil; Darias; Sanchez Mateo; Exposito
Pharmazie, 1995 , vol. 50, # 1 p. 27 - 33 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
antagonist
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Species or TestSystem (Pharmacological Data)
COS-7 cells
Exposure Period (Pharmacological Data)
1 h
Method (Pharmacological Data)
cells transfected with cDNA of human plasmalemmal dopamine transporter (DAT) cells and vesicular amine transporter (DAT/VAT) cells exposed for to 0.3 μM <3H>dopamine and title compound
Further Details (Pharmacological Data)
liquid scintillation counted
Results
inhibited initial rate of <3H>dopamine uptake (5 min accumulation) with Ki of 0.29 μM (DAT) and 0.7 μM (DAT/VAT)
Reference
Pifl, Christian; Drobny, Helmut; Reither, Harald; Hornykiewicz, Oleh; Singer, Ernst A.
Molecular Pharmacology, 1995 , vol. 47, # 2 p. 368 - 373 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
dopaminergic
Species or TestSystem (Pharmacological Data)
COS-7 cells
Concentration (Pharmacological Data)
0.01 - 100 μmol/l
Exposure Period (Pharmacological Data)
4 min
Method (Pharmacological Data)
cells transfected with cDNA of human plasmalemmal dopamine transporter (DAT) cells; labelling with 0.3 μM <3H>dopamine at 37 deg C, 60 min; title compound added to superfusion medium
Further Details (Pharmacological Data)
liquid scintillation counted
Type (Pharmacological Data)
EC50
Value of Type (Pharmacological Data)
1.1 μmol/l
Results
rapid but transient <3H>dopamine release, maximum at 10 μM of title compound; cocain (1 or 10 μM) decreased this effect (caused a shift to the right of the concentration-response curve)
Reference
Pifl, Christian; Drobny, Helmut; Reither, Harald; Hornykiewicz, Oleh; Singer, Ernst A.
Molecular Pharmacology, 1995 , vol. 47, # 2 p. 368 - 373 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
dopaminergic
Species or TestSystem (Pharmacological Data)
COS-7 cells
Exposure Period (Pharmacological Data)
4 min
Method (Pharmacological Data)
cells transfected with cDNA of human plasmalemmal dopamine and vesicular amine transporter (DAT/VAT) cells, title compound added to superfusion medium containing 0.3 μM <3H>dopamine
Further Details (Pharmacological Data)
liquid scintillation counting
Results
rapid and reversible concentration dependent increase in <3H>dopamine efflux, saturation not observed at concentration up to 100 μM
Reference
Pifl, Christian; Drobny, Helmut; Reither, Harald; Hornykiewicz, Oleh; Singer, Ernst A.
Molecular Pharmacology, 1995 , vol. 47, # 2 p. 368 - 373
Title/Abstract Full Text View citing articles Show Details
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Effect (Pharmacological Data)
dopaminergic
Species or TestSystem (Pharmacological Data)
COS-7 cells
Concentration (Pharmacological Data)
10 μmol/l
Exposure Period (Pharmacological Data)
36 min
Method (Pharmacological Data)
cells were transfected with cDNA of human synaptic vesicle amine transporter (VAT) cells; exposed with 1 μM <3H>dopamine for 1 h; title compound added to buffer from 12 min until the end of experiment
Further Details (Pharmacological Data)
liquid scintillation counted
Results
small stepwise increase in <3H>dopamine release
Reference
Pifl, Christian; Drobny, Helmut; Reither, Harald; Hornykiewicz, Oleh; Singer, Ernst A.
Molecular Pharmacology, 1995 , vol. 47, # 2 p. 368 - 373 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
dopaminergic
Species or TestSystem (Pharmacological Data)
COS-7 cells
Concentration (Pharmacological Data)
1 μmol/l
Exposure Period (Pharmacological Data)
36 min
Method (Pharmacological Data)
cells were transfected with cDNA of human plasmalemmal dopamine- and vesicular amine- transporter (DAT/VAT cells); exposed with 0.3 μM <3H>dopamine for 1 h; title compound was added to buffer from 12 min until the end of experiment
Further Details (Pharmacological Data)
liquid scintillation counted
Results
increase of efflux of <3H>dopamine that remained elevated above base-line values after it had reached its peak
Reference
Pifl, Christian; Drobny, Helmut; Reither, Harald; Hornykiewicz, Oleh; Singer, Ernst A.
Molecular Pharmacology, 1995 , vol. 47, # 2 p. 368 - 373 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
dopaminergic
Species or TestSystem (Pharmacological Data)
COS-7 cells
Concentration (Pharmacological Data)
1 μmol/l
Exposure Period (Pharmacological Data)
36 min
Method (Pharmacological Data)
cells were transfected with cDNA of human plasmalemmal dopamine transporter (DAT cells); exposed with 0.3 μM <3H>dopamine for 1 h; title compound was added to buffer from 12 min until the end of experiment
Further Details (Pharmacological
liquid scintillation counted
Data)
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Results
<3H>dopamine efflux reached a maximum within 8 min, and subsequently returned to base-line in spite of the containing presence of title compound
Reference
Pifl, Christian; Drobny, Helmut; Reither, Harald; Hornykiewicz, Oleh; Singer, Ernst A.
Molecular Pharmacology, 1995 , vol. 47, # 2 p. 368 - 373 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
stimulation of efflux
Species or TestSystem (Pharmacological Data)
LLC-PK1 cells
Exposure Period (Pharmacological Data)
30 min
Method (Pharmacological Data)
cells transfected with cDNA encoding rat serotonin transporter (SERT), human norepinephrine transporter (NET) or rat dopamine transporter (DAT); incubated with radiolabelled 5-HT (SERT) or 1-methyl-4-phenylpyridinium(1+) (MPP) at 37 deg C
Further Details (Pharmacological Data)
washing, 30 min incubation with title comp.; activity measured; at concentration that inhibited transport by 80 percent
Results
title comp. increased MPP by 58 percent (NET), 48 percent (DAT), 5-HT efflux by 7 percent (SERT); 50μM mazindol decreased this effect; diagram given
Reference
Wall, Stephen C.; Gu, Howard; Rudnick, Gary
Molecular Pharmacology, 1995 , vol. 47, # 3 p. 544 - 550 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
transporter, inhibition of
Species or TestSystem (Pharmacological Data)
LLC-PK1 cells
Exposure Period (Pharmacological Data)
4 min
Method (Pharmacological Data)
cells transfected with cDNA encoding SERT, NET or DAT; incubation with radiolabeled 5-HT (SERT) or MPP(1+) (NET and DAT) and title comp. at room temp.; uptake of activity measured
Results
potent inhibitor for all three transporters; diagram given
Reference
Wall, Stephen C.; Gu, Howard; Rudnick, Gary
Molecular Pharmacology, 1995 , vol. 47, # 3 p. 544 - 550 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
Accumulation
Species or TestSystem (Pharmacological Data)
human
Sex
male
Method (Pharmacological Data)
chronic drug abuse; sampling head hair and fingernail; hot alkaline hydrolysis; deuterated internal standard; three-step extraction procedure; derivatization by propionylation; GC/MS analysis
Further Details (Pharmacological Data)
22-year old male
Results
concentration: 10.2 ng/mg in hair and 12.0 ng/mg in fingernail
Reference
Cirimele; Kintz; Mangin
Archives of Toxicology, 1995 , vol. 70, # 1 p. 68 - 69 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological
AUC
Data)
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Species or TestSystem (Pharmacological Data)
dark-agouti rat
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
2.5 mg/kg
Kind of Dosing (Pharmacological Data)
drug administered once a day for 10 successive days
Exposure Period (Pharmacological Data)
10 d
Method (Pharmacological Data)
rats 5 weeks old; back hair shaved before experiment; blood samples collected 5, 15, 30, 60, 120, 360 min after drug administration; newly grown hair samples collected 4 weeks after first drug administration
Further Details (Pharmacological Data)
drug level in plasma and hair determination; GC/MS; HPLC
Type (Pharmacological Data)
AUC
Value of Type (Pharmacological Data)
85.3 μg*min/ml
Results
concentration in hair <H> = 13.2 ng/mg; drug incorporation rate ICR (<H>/AUC) = 0.15
Reference
Nakahara; Takahashi; Kikura
Biological and Pharmaceutical Bulletin, 1995 , vol. 18, # 9 p. 1223 - 1227 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
hyperlocomotion inducer
Species or TestSystem (Pharmacological Data)
Wistar rats
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
0.16 - 2.5 mg/kg
Method (Pharmacological Data)
rats placed into cages, movement recorded for 60 min by infrared beams
Further Details (Pharmacological Data)
effect of dopamine D2 and 5-HT2A receptor antagonists on hyperlocomotion caused by title compound
Results
title compound dose dependently elicited hyperlocomotion; this effect blocked by dopamine D2 receptor antagonists (r = 0.94) more effectively than by 5-HT2A antagonists (r = 0.37)
Reference
Maurel-Remy; Bervoets; Millan
European Journal of Pharmacology, 1995 , vol. 280, # 2 p. R9-R11 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
sensitization of mesolimbic dopamine function
Species or TestSystem (Pharmacological Data)
Long-Evans rat
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Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
2 mg/kg
Method (Pharmacological Data)
rats (300-400 g) with partial depletion of prefrontal cortex dopamine (microinfusion of 6-hydroxydopamine); title comp.-induced sensitization (4.0 mg/kg i.p., 5 once-daily inj.) six weeks later; high-speed chronoamperometry; controlled study
Further Details (Pharmacological Data)
post-mortem levels of dopamine, dihydroxyphenylacetic acid, norepinephrine and serotonin in prefrontal cortex and nucleus accumbens of 6-hydroxydopamine-lesioned and sham-lesioned animals
Results
increase in dopamine-dependent electrochemical signal
Reference
Banks; Gratton
European Journal of Pharmacology, 1995 , vol. 282, # 1-3 p. 157 - 167 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
behavioural symptoms
Species or TestSystem (Pharmacological Data)
Long-Evans rat
Sex
male
Route of Application
intraperitoneal
Concentration (Pharmacological Data)
0.5 mg/kg
Method (Pharmacological Data)
rats (300-400 g) with partial depletion of prefrontal cortex dopamine (microinfusion of 6-hydroxydopamine); title comp.-induced sensitization (1.0 mg/kg i.p., 5 once-daily inj.); challenge inj. of title comp. 5 and 13 days later; total activity counts
Results
prefrontal cortex-lesioned animals were less responsive to the first inj. of title comp. than sham-lesioned animals; after repeated daily admin., the acute locomotor response of lesioned animals was signif. greater than that of sham-lesioned animals
Reference
Banks; Gratton
European Journal of Pharmacology, 1995 , vol. 282, # 1-3 p. 157 - 167 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
drug interaction
Species or TestSystem (Pharmacological Data)
mice
Concentration (Pharmacological Data)
2 mg/kg
Method (Pharmacological Data)
title compound injected 0.5 h after 0.01 - 16 mg/kg MDL 100,907 i.p.; locomotor activity measured during 90 min test means
Further Details (Pharmacological Data)
T.I.: estimated ED50 for depressing locomotion in vehicle treated mice/ ED50 for reducing title compound stimulated locomotion; MDL 100,907 :R-(+)-α-(2,3-dimethoxyphenyl)-1-<2-(4-fluorophenylethyl)>-4-piperidinemethanol
Results
estimated ED50 for title compound induced locomotion reduction 0.08 mg/kg, for baseline locomotion reduction 7.2 mg/kg; calculated T.I.= 90
Reference
Schmidt; Sorensen; Kehne; Carr; Palfreyman
Life Sciences, 1995 , vol. 56, # 25 p. 2209 - 2222 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
cardiovascular
Species or TestSystem (Pharmacological Data)
Sprague-Dawley rat
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Sex
male
Route of Application
intravenous
Concentration (Pharmacological Data)
0.5 - 1.25 mg/kg
Method (Pharmacological Data)
rat (250-300 g) used
Further Details (Pharmacological Data)
mean arterial pressure (MAP, measured with Gold universal preamplifier), heart rate (HR), striatal dopamine (DA) release (voltammetric measurements)
Results
title comp. produced hypertension, tachycardia and increased striatal DA release
Reference
Chueh; Hsieh; Chen; Lin
Pharmacology, 1995 , vol. 51, # 4 p. 237 - 244 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
cardiovascular
Species or TestSystem (Pharmacological Data)
Sprague-Dawley rat
Sex
male
Route of Application
intravenous
Concentration (Pharmacological Data)
0.5 mg/kg
Method (Pharmacological Data)
rat (250-300 g) treated with title comp. with 10 mg/kg DL-tetrahydropalmatine (THP)
Further Details (Pharmacological Data)
mean arterial pressure (MAP, measured with Gold universal preamplifier), heart rate (HR), striatal dopamine (DA) release (voltammetric measurements)
Results
title comp. completely reversed THP-induced hypotension and bradycardia; DA release increased during combined treatment
Reference
Chueh; Hsieh; Chen; Lin
Pharmacology, 1995 , vol. 51, # 4 p. 237 - 244 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
receptor blocking agent
Species or TestSystem (Pharmacological Data)
rat C6 glicoma cells
Method (Pharmacological Data)
in vitro; cells were transfected with pcDNA1-hDAT; pretreatment with title comp. for 10 min before add. of <3H>dopamine (20 nM, 35.1 Ci/mmol); radioligand binding assay
Further Details (Pharmacological Data)
title comp. was tested by use at least six concentration for determination of Ki value
Type (Pharmacological Data)
Ki
Value of Type (Pharmacological Data)
208 nmol/l
Reference
Eshleman; Neve; Janowsky
Journal of Pharmacology and Experimental Therapeutics, 1995 , vol. 274, # 1 p. 276 - 283 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
receptor; binding activity
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Species or TestSystem (Pharmacological Data)
COS-7 cells
Method (Pharmacological Data)
in vitro; cells were transfected with pcDNA1-hDAT; pretreatment with title comp. for 10 min before add. of <3H>-2β-carbomethoxy-3β(4-fluorophenyl)tropane (<3H>CFT, 85.9 Ci/mmol) diluted with unlabeled comp.(1 pM to 10 μM); radioligand binding assay
Further Details (Pharmacological Data)
title comp. was tested by use at least nine concentration for determination of Ki value
Type (Pharmacological Data)
Ki
Value of Type (Pharmacological Data)
2000 nmol/l
Reference
Eshleman; Neve; Janowsky
Journal of Pharmacology and Experimental Therapeutics, 1995 , vol. 274, # 1 p. 276 - 283 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
receptor; binding activity
Species or TestSystem (Pharmacological Data)
COS-7 cells
Method (Pharmacological Data)
in vitro; cells were transfected with pcDNA1-hDAT; pretreatment with title comp. for 10 min before add. of <3H>GBR-12935; radioligand binding assay
Further Details (Pharmacological Data)
title comp. was tested by use at least nine concentration for determination of Ki value
Type (Pharmacological Data)
Ki
Value of Type (Pharmacological Data)
4342 nmol/l
Reference
Eshleman; Neve; Janowsky
Journal of Pharmacology and Experimental Therapeutics, 1995 , vol. 274, # 1 p. 276 - 283 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
regulation of striatal cAMP
Species or TestSystem (Pharmacological Data)
Sprague-Dawley rat brain
Sex
male
Concentration (Pharmacological Data)
10 μmol/l
Method (Pharmacological Data)
in vitro; brain slices from rats (180-200 g); effects of title comp. on cAMP formation and accumulation in the presence of 3 μM sulpiride, 300 μM 1-aminocyclopentane-1s,3R-dicarboxylic acid (ACPD); radioimmunoassay
Results
title comp. and sulpiride enhanced dopamine D1 receptor induced cAMP formation in the control and in the presence of APCD, by 67 percent and 74 percent, resp.
Reference
Wang; Johnson
Journal of Pharmacology and Experimental Therapeutics, 1995 , vol. 275, # 2 p. 877 - 884 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
effects on chronotropic responses in female rat isolated atria
Reference
Fitzgerald; Reid
Journal of Pharmacy and Pharmacology, 1994 , vol. 46, # 10 p. 826 - 832 Title/Abstract Full Text View citing articles Show Details
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Effect (Pharmacological Data)
agonist
Species or TestSystem (Pharmacological Data)
swiss albino mice
Sex
male
Route of Application
subcutaneous
Concentration (Pharmacological Data)
1.25 mg/kg
Method (Pharmacological Data)
28 g mice
Further Details (Pharmacological Data)
grooming score ibolishing in the presence of L-DOPA; dopamine agonist
Results
climbing and sniffing scores were 31.6 and 57.3, respectively in mice treated with L-DOPA (75 mg/kg)
Reference
Protais; Chagraoui; Arbaoui; Mocaer
European Journal of Pharmacology, 1994 , vol. 271, # 1 p. 167 - 177 Title/Abstract Full Text View citing articles Show Details
Effect (Pharmacological Data)
dystonic syndrome
Species or TestSystem (Pharmacological Data)
man
Sex
male
Method (Pharmacological Data)
a 28 year old man; drunk a whole bottle of vodka and that this had been 'spiked' with 'Whizz', a test chemical
Results
following an overdose of 'Whizz' and alcohol a protracted dystonic syndrome can developed, clinically indistinguishable from tetanus
Reference
Humphreys; Tanner
Human and Experimental Toxicology, 1994 , vol. 13, # 5 p. 311 - 312 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
acute toxicity LD50 = 13 mg/kg (mice)
Reference
Shivanyuk; Losev; Vargashkin; Bobkov; Lozinskii
Pharmaceutical Chemistry Journal, 1992 , vol. 26, # 5 p. 430 - 432 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
binding affinity at 5-HT1C and 5-HT2 serotonin receptors; lack of selectivity
Reference
Glennon, Richard A.; Raghupathi, Reva; Bartyzel, Piotr; Teitler, Milt; Leonhardt, Sigrun
Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 734 - 740 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
spasmolytical, central nervous system depressant, and antiinflammatory activity (mice)
Reference
Shivanyuk; Losev; Vargashkin; Bobkov; Lozinskii
Pharmaceutical Chemistry Journal, 1992 , vol. 26, # 5 p. 430 - 432 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
no affinity at σ binding sites (rat cerebellar homogenate), does not bind at PCP sites
Reference
Glennon, Richard A.; Smith, J. Doyle; Ismaiel, Abd M.; El-Ashmawy, Mahmoud; Battaglia, George; Fisher, James B.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1094 - 1098 Title/Abstract Full Text View citing articles Show Details
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Comment (Pharmacological Data)
binding affinity to 5-HT1 and 5-HT2 sites
Reference
Glennon, Richard A.; McKenney, J. D.; Lyon, Robert A.; Titeler, Milt
Journal of Medicinal Chemistry, 1986 , vol. 29, # 2 p. 194 - 199 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
LD 50: 80 mg/kg (mice, intraperitoneally)
Reference
Sarkisyan, A. B.; Solomina, L. P.; Pirdzhanov, L. Sh.; Markaryan, E. A.; Arzanunt, E. M.; et al.
Pharmaceutical Chemistry Journal, 1985 , vol. 19, # 4 p. 256 - 258 Khimiko-Farmatsevticheskii Zhurnal, 1985 , vol. 19, # 4 p. 423 - 425 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
at dose 3 mg/kg effects on apomorphine-induced (0.6 mg/kg s.c.) stereotyped behaviour (Sprague-Dawley rats)
Reference
Depin; Betbeder-Matibet; Bonhomme; Muller; Berthelon
Arzneimittel-Forschung/Drug Research, 1985 , vol. 35, # 11 p. 1655 - 1662 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
inhibition of dopamine uptake by rat striatum synaptosomes (IC 50: 6.9E-7 mol/l), at doses 1E-5 mol/l increases biogenic amines norepinephrine (2E-8 mol/l) release (222616 dpm/ml/mg tissue/10 min, rat brain cortex slices)
Reference
Depin; Betbeder-Matibet; Bonhomme; Muller; Berthelon
Arzneimittel-Forschung/Drug Research, 1985 , vol. 35, # 11 p. 1655 - 1662 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
ability to inhibit the potassium-evoked release of <3H>acetylcholine from stratial slices after depletion of dopamine stores with reserpine and α-methyl-p-tyrosine
Reference
Hamada, Akihiko; Chang, Yu An; Uretsky, Norman; Miller, Duane D.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 675 - 680 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
LD 50: 137 mg/kg - intraperitoneally (mice); effect on the physical endurance - intraperitoneally (rat)
Reference
Gevorkyan, K. A.; Papayan, G. L.; Shirinyan, E. A.; Atayan, T. K.; Vorskanyan, A. S.
Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 7 p. 484 - 487 Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 7 p. 806 - 808 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
antinociceptive activity: inhibition of acetylcholine writhing (mouse) ED50 = 1.6 mg/kg po, inflamed paw pressure treshold (rat) ED50 = 2.1 mg/kg po; behavioral stimulant activity
Reference
Harris; Middlemiss; Mills; Gower; Tyers
Journal of Medicinal Chemistry, 1983 , vol. 26, # 1 p. 55 - 60 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
influence on spontaneous locomotor activity (20 mg/kg, s.c., mouse)
Reference
Pittner
Arzneimittel-Forschung/Drug Research, 1983 , vol. 33, # 1 A p. 13 - 25 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
decreases the body temperature (25 mg/kg, i.p., rats), increases the exploratory activity, ED 50: 21 mg/kg (p.o., mice); inhibition of muricidal behaviour, ED50: 1.5 mg/kg p.o.; increases the locomotor activity in mice (5 mg/kg i.v.)
Reference
Jahn; Adrian; Ismail; Michos
Arzneimittel-Forschung/Drug Research, 1983 , vol. 33, # 5 p. 726 - 730 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
inhibition of norepinephrine N-methyltransferase (NMT)
Reference
Grunewald, Gary L.; Monn, James A.; Rafferty, Michael F,; Borchardt, Ronald T.; Krass, Polina
Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1248 - 1250 Title/Abstract Full Text View citing articles Show Details
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Comment (Pharmacological Data)
decreased the body mass; increased plasma free fatty acids; stimulated adrenocortical function; no effect on plasma glucose, liver glycogen and phosphorylase activity <chronic treatment of albino rats with amphetamine (4 mg/kg body mass)>
Reference
Hamdy; Fahim
Pharmazie, 1982 , vol. 37, # 3 p. 206 - 208 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
behavioral properties (discriminative stimulus) in animals
Reference
Glennon; Young; Benington; Morin
Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1163 - 1168 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
inhibition of rat pancreatic lipase
Reference
Comai; Sullivan
Journal of Pharmaceutical Sciences, 1982 , vol. 71, # 4 p. 418 - 421 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
norepinephrine N-methyltransferase (NMT) inhibition constant
Reference
Rafferty, Michael F.; Wilson, David S.; Monn, James A.; Krass, Polina; Borchardt, Ronald T.; Grunewald, Gary L.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1198 - 1204 Title/Abstract Full Text View citing articles Show Details
Rafferty; Borchardt; Grunewald
Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1204 - 1208 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
serum, brain, liver concentrations (rat)
Reference
Javaid; Davis
Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 7 p. 813 - 815 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
decreases the responses of the electrically stimulated guinea-pig ileum
Reference
Little; Rees
Journal of Pharmacy and Pharmacology, 1980 , vol. 32, # 11 p. 751 - 756 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
pharmacokinetics in humans: PEU, EXC
Reference
Testa; Salvesen
Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 5 p. 497 - 501 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
affinity for the serotonin receptor (rat stomach fundus preparation)
Reference
Glennon; Liebowitz; Anderson III
Journal of Medicinal Chemistry, 1980 , vol. 23, # 3 p. 294 - 299 Title/Abstract Full Text View citing articles Show Details
Comment (Pharmacological Data)
inhibitor of the neuronal and extraneural binding of noradrenaline; Sprague-Dawley rat, i.v.
Reference
Jacquot; Rapin
Arzneimittel-Forschung/Drug Research, 1980 , vol. 30, # 5 p. 776 - 779 Title/Abstract Full Text View citing articles Show Details
Other Data Exposure Assessment (2) 1 of 2
Exposure
presence in surface water; Llobregat River, its main tributaries (Cardener River and Anoia River) and Rubi creek in NE Spain; sampling in
January, March and May 2007
2 of 2
Sources
human source contaminants
Reference
Huerta-Fontela, Maria; Galceran, Maria Teresa; Ventura, Francesc
Environmental Science and Technology, 2008 , vol. 42, # 18 p. 6809 - 6816 Title/Abstract Full Text View citing articles Show Details
Exposure
presence in hair and fingernails; 22-year-old male
Sources
chronic drug abuse
Reference
Cirimele; Kintz; Mangin
Archives of Toxicology, 1995 , vol. 70, # 1 p. 68 - 69 Title/Abstract Full Text View citing articles Show Details
Concentration in the Environment (13) 1 of 13
2 of 13
3 of 13
4 of 13
Media (Concentration in the Environment)
sewage water
Location
Gandia, Spain
Contamination Concentration
6.5 ng/l
Method, Remarks (Concentration in the Environment)
samples collected from STP of tourist cites of Gandia; influent 24-h composite samples collected on 26th of July 2007; solid-phase extraction-liquid chromatography-electrospray-tandem mass spectrometry
Reference
Postigo, Cristina; Lopez De Alda, Maria J.; Barcelo, Damia
Analytical Chemistry, 2008 , vol. 80, # 9 p. 3123 - 3134 Title/Abstract Full Text View citing articles Show Details
Media (Concentration in the Environment)
sewage water
Location
Gandia, Spain
Contamination Concentration
3.3 ng/l
Method, Remarks (Concentration in the Environment)
samples collected from STP of tourist cites of Gandia; effluent 24-h composite samples collected on 26th of July 2007; solid-phase extraction-liquid chromatography-electrospray-tandem mass spectrometry
Reference
Postigo, Cristina; Lopez De Alda, Maria J.; Barcelo, Damia
Analytical Chemistry, 2008 , vol. 80, # 9 p. 3123 - 3134 Title/Abstract Full Text View citing articles Show Details
Media (Concentration in the Environment)
sewage water
Location
Benicassim, Spain
Contamination Concentration
35.5 ng/l
Method, Remarks (Concentration in the Environment)
samples collected from STP of tourist cites of Benicassim; influent 24-h composite samples collected on 26th of July 2007; solid-phase extraction-liquid chromatography-electrospray-tandem mass spectrometry
Reference
Postigo, Cristina; Lopez De Alda, Maria J.; Barcelo, Damia
Analytical Chemistry, 2008 , vol. 80, # 9 p. 3123 - 3134 Title/Abstract Full Text View citing articles Show Details
Media (Concentration in the Environment)
sewage water
Location
Benicassim, Spain
Contamination Concentration
1.0 ng/l
Method, Remarks (Concentration in the Environment)
samples collected from STP of tourist cites of Benicassim; effluent 24-h composite samples collected on 26th of July 2007; solid-phase extraction-liquid chromatography-electrospray-tandem mass spectrometry
Reference
Postigo, Cristina; Lopez De Alda, Maria J.; Barcelo, Damia
Analytical Chemistry, 2008 , vol. 80, # 9 p. 3123 - 3134 Title/Abstract Full Text View citing articles Show Details
5 of 13
6 of 13
7 of 13
8 of 13
9 of 13
10 of 13
Media (Concentration in the Environment)
sewage water
Location
Valencia, Spain
Contamination Concentration
20.4 ng/l
Method, Remarks (Concentration in the Environment)
samples collected from STP of tourist cites of Valencia; influent 24-h composite samples collected on 26th of July 2007; solid-phase extraction-liquid chromatography-electrospray-tandem mass spectrometry
Reference
Postigo, Cristina; Lopez De Alda, Maria J.; Barcelo, Damia
Analytical Chemistry, 2008 , vol. 80, # 9 p. 3123 - 3134 Title/Abstract Full Text View citing articles Show Details
Media (Concentration in the Environment)
sewage water
Location
Valencia, Spain
Contamination Concentration
2.2 ng/l
Method, Remarks (Concentration in the Environment)
samples collected from STP of tourist cites of Valencia; effluent 24-h composite samples collected on 26th of July 2007; solid-phase extraction-liquid chromatography-electrospray-tandem mass spectrometry
Reference
Postigo, Cristina; Lopez De Alda, Maria J.; Barcelo, Damia
Analytical Chemistry, 2008 , vol. 80, # 9 p. 3123 - 3134 Title/Abstract Full Text View citing articles Show Details
Media (Concentration in the Environment)
sewage water
Location
Barcelona, Spain
Contamination Concentration
41.1 ng/l
Method, Remarks (Concentration in the Environment)
samples collected from major STP of Barcelona; influent 24-h composite samples collected every day during first week of July 2007; solidphase extraction-liquid chromatography-electrospray-tandem mass spectrometry
Reference
Postigo, Cristina; Lopez De Alda, Maria J.; Barcelo, Damia
Analytical Chemistry, 2008 , vol. 80, # 9 p. 3123 - 3134 Title/Abstract Full Text View citing articles Show Details
Media (Concentration in the Environment)
sewage water
Location
Barcelona, Spain
Contamination Concentration
0.5 ng/l
Method, Remarks (Concentration in the Environment)
samples collected from major STP of Barcelona; effluent 24-h composite samples collected every day during first week of July 2007; solidphase extraction-liquid chromatography-electrospray-tandem mass spectrometry
Reference
Postigo, Cristina; Lopez De Alda, Maria J.; Barcelo, Damia
Analytical Chemistry, 2008 , vol. 80, # 9 p. 3123 - 3134 Title/Abstract Full Text View citing articles Show Details
Media (Concentration in the Environment)
surface water
Location
Llobregat River, NE Spain
Contamination Concentration
5 - 90 ng/l
Method, Remarks (Concentration in the Environment)
samples collected during January to June 2007; analyzed by ultraperformance LC-ESI/MS/MS in selected reaction monitoring mode
Reference
Huerta-Fontela, Maria; Galceran, Maria Teresa; Ventura, Francesc
Environmental Science and Technology, 2008 , vol. 42, # 18 p. 6809 - 6816 Title/Abstract Full Text View citing articles Show Details
Media
surface water
(Concentration in the Environment)
11 of 13
12 of 13
13 of 13
Location
Llobregat River, NE Spain
Contamination Concentration
0.4 - 50 ng/l
Method, Remarks (Concentration in the Environment)
mean conc.; samples collected once a week every Monday and at the same time (10:00 am) during March 2006 to May 2007 at the intake of a drinking water treatment plant; analyzed by ultraperformance LC-ECI/MS/MS in selected reaction monitoring mode
Reference
Huerta-Fontela, Maria; Galceran, Maria Teresa; Ventura, Francesc
Environmental Science and Technology, 2008 , vol. 42, # 18 p. 6809 - 6816 Title/Abstract Full Text View citing articles Show Details
Media (Concentration in the Environment)
surface water
Location
Llobregat River basin, NE Spain
Contamination Concentration
0 - 50 ng/l
Method, Remarks (Concentration in the Environment)
mean conc.; samples collected over 7 consecutive days at the same time (10:00 am) during December 2006 at the intake of a drinking water treatment plant; analyzed by ultraperformance LC-ESI/MS/MS in selected reaction monitoring mode
Reference
Huerta-Fontela, Maria; Galceran, Maria Teresa; Ventura, Francesc
Environmental Science and Technology, 2008 , vol. 42, # 18 p. 6809 - 6816 Title/Abstract Full Text View citing articles Show Details
Media (Concentration in the Environment)
wastewater
Location
Nosedo (Milan), Italy
Contamination Concentration
0 - 14.7 ng/l
Method, Remarks (Concentration in the Environment)
8 water sample collected during 1 week in February 2006 from wastewater treatment plant influents and effluents; HPLC-MS-MS analyzed
Reference
Castiglioni, Sara; Zuccato, Ettore; Crisci, Elisabetta; Chiabrando, Chiara; Fanelli, Roberte; Bagnati, Renzo
Analytical Chemistry, 2006 , vol. 78, # 24 p. 8421 - 8429 Title/Abstract Full Text View citing articles Show Details
Species (Concentration in the Environment)
human
Location
United States
Contamination Concentration
0.038 - 1.019 mg/kg
Method, Remarks (Concentration in the Environment)
in meconium; 7 samples belonged to mothers who declared heavy methamphetamine abuse during pregnancy; internal standard; methanol-HCl treatment; Bond Elut Certify solid-phase extraction column; HPLC-MS; in positive ESI mode; SIM acquisition
Reference
Pichini, Simona; Pacifici, Roberta; Pellegrini, Manuela; Marchei, Emilia; Lozano, Jaime; Murillo, Janeth; Vall, Oriol; GarciaAlgar, Oscar
Analytical Chemistry, 2004 , vol. 76, # 7 p. 2124 - 2132 Title/Abstract Full Text View citing articles Show Details
Use (284) Use Pattern
Location
Reference
Pharmaceuticals
Page/Page column 22-30
JANSSEN PHARMACEUTICA NV; DVORAK, Curt A.; LIU, Changlu; KUEI, Chester
Patent: WO2014/152917 A2, 2014 ;
Page/Page column 22-30
JANSSEN PHARMACEUTICA NV; DVORAK, Curt A.; LIU, Changlu; KUEI, Chester
Patent: WO2014/152917 A2, 2014 ;
Page/Page column 22-30
JANSSEN PHARMACEUTICA NV; DVORAK, Curt A.; LIU, Changlu; KUEI, Chester
Patent: WO2014/152917 A2, 2014 ;
activating GPR139
for detecting GPR139 activation
Title/Abstract Full Text Show Details
Title/Abstract Full Text Show Details
Title/Abstract Full Text Show Details
modulating Phenylketonuria (PKU)
modulating a neurological function
dopaminergic agent for combination therapy
Page/Page column 22-30
JANSSEN PHARMACEUTICA NV; DVORAK, Curt A.; LIU, Changlu; KUEI, Chester
Patent: WO2014/152917 A2, 2014 ;
Page/Page column 22-30
JANSSEN PHARMACEUTICA NV; DVORAK, Curt A.; LIU, Changlu; KUEI, Chester
Patent: WO2014/152917 A2, 2014 ;
Acadia Pharmaceuticals, Inc.
Patent: US2009/82342 A1, 2009 ;
Title/Abstract Full Text Show Details
Title/Abstract Full Text Show Details
Title/Abstract Full Text Show Details
psychostimulant
Poestges, Reiner; Schneider, Bernd; Ammer, Richard
Patent: US2008/75769 A1, 2008 ; Title/Abstract Full Text Show Details
H. LUNDBECK A/S
Patent: WO2009/76961 A1, 2009 ; Title/Abstract Full Text Show Details
Attention Deficit Hyperactivity Disorder (ADHD)
MEMORY PHARMACEUTICALS CORPORATION
Patent: WO2005/51389 A1, 2005 ; Title/Abstract Full Text Show Details
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2007/93624 A2, 2007 ; Title/Abstract Full Text Show Details
Poestges, Reiner; Schneider, Bernd; Ammer, Richard
Patent: US2008/75769 A1, 2008 ; Title/Abstract Full Text Show Details
narcolepsy
Kirk, Randal J.
Patent: US2006/100136 A1, 2006 ; Title/Abstract Full Text Show Details
Poestges, Reiner; Schneider, Bernd; Ammer, Richard
Patent: US2008/75769 A1, 2008 ; Title/Abstract Full Text Show Details
obesity
Kirk, Randal J.
Patent: US2006/100136 A1, 2006 ; Title/Abstract Full Text Show Details
GELESIS, INC.
Patent: WO2007/112436 A2, 2007 ; Title/Abstract Full Text Show Details
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
Anorectic agent
Nettekoven, Matthias; Plancher, Jean-Marc; Richter, Hans; Roche, Olivier; Rodriguez Sarmiento, Rosa Maria; Taylor, Sven
Patent: US2007/123526 A1, 2007 ; Title/Abstract Full Text Show Details
Nettekoven, Matthias Heinrich; Roche, Olivier
Patent: US2007/270423 A1, 2007 ; Title/Abstract Full Text Show Details
Nettekoven, Matthias; Roche, Olivier
Patent: US2008/32976 A1, 2008 ; Title/Abstract Full Text Show Details
Hebeisen, Paul; Roever, Stephan
Patent: US2008/70931 A1, 2008 ; Title/Abstract Full Text Show Details
bulimia
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ;
Title/Abstract Full Text Show Details
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
Attention Deficit Disorder (ADD)
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2007/93624 A2, 2007 ;
Title/Abstract Full Text Show Details
Poestges, Reiner; Schneider, Bernd; Ammer, Richard
Patent: US2008/75769 A1, 2008 ; Title/Abstract Full Text Show Details
potentiating a therapeutic effect of an endogenous alpha-2 adrenergic receptor agonist
fatigue symptom associated with fibromyalgia syndrome (FMS)
Neuronal cell damage
Jhamandas, Khem; Milne, Brian
Patent: US2008/20076 A1, 2008 ; Title/Abstract Full Text Show Details
CYPRESS BIOSCIENCE, INC.
Patent: WO2008/19388 A2, 2008 ; Title/Abstract Full Text Show Details
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
Death caused by transient cerebral hypoxia
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ;
Title/Abstract Full Text Show Details
Death caused by transient cerebral ischemia
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ;
Title/Abstract Full Text Show Details
transient cerebral hypoxia
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ;
Title/Abstract Full Text Show Details
Transient ischemic condition
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ;
Title/Abstract Full Text Show Details
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Use Pattern
Location
Reference
Neuronal cell damage caused by transient cerebral hypoxia
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
Neuronal cell damage caused by transient cerebral ischemia
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
cerebral hypoxic condition
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
Cerebral ischemic condition
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
transient cerebral hypoxic condition caused by loss of blood
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
transient cerebral hypoxic condition caused by a heart attack
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
transient cerebral hypoxic condition caused by strangulation
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
transient cerebral hypoxic condition caused by surgery
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
transient cerebral hypoxic condition caused by cardiac surgery
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
transient cerebral hypoxic condition caused by stroke
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
transient cerebral hypoxic condition caused by air-way blockage
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
transient cerebral hypoxic condition caused by ischemic optic neuropathy
transient cerebral hypoxic condition caused by spinal cord injuries
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
transient cerebral hypoxic condition caused by traumatic brain injury
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
transient cerebral hypoxic condition caused by low blood pressure
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
transient cerebral ischemic condition caused by loss of blood
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
transient cerebral ischemic condition caused by a heart attack
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
transient cerebral ischemic condition caused by strangulation
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
transient cerebral ischemic condition caused by surgery
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
transient cerebral ischemic condition caused by cardiac surgery
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ;
Title/Abstract Full Text Show Details
transient cerebral ischemic condition caused by a stroke
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
transient cerebral ischemic condition caused by air-way blockage
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
transient cerebral ischemic condition caused by ischemic optic neuropathy
transient cerebral ischemic condition caused by spinal cord injuries
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
transient cerebral ischemic condition caused by traumatic brain injury
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
transient cerebral ischemic condition caused by low blood pressure
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
Neuronal cell damage due to lack of oxygen reaching the neuronal cells
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
Neuronal cell damage due to lack of glucose reaching the neuronal cells
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
Ischemic condition
THE UNIVERSITY OF MONTANA
Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details
anti-obesity agent
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
disorder associated with excessive food intake
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
obesity related disorders
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
overeating
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
elevated plasma insulin concentrations
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
insulin resistance
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
dyslipidemias
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
hyperlipidemia
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
endometrial cancer
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
breast cancer
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
prostate cancer
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
colon cancer
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
osteoarthritis
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
obstructive sleep apnea
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
gallstones
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
abnormal heart rhythms
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
heart arrythmias
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
myocardial infarction
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
congestive heart failure
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.;
Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ;
Title/Abstract Full Text Show Details
coronary heart disease
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
sudden death
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
stroke
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
polycystic ovarian disease
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
craniopharyngioma
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
the Prader-Willi Syndrome
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
Frohlich's syndrome
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
GH-deficient subjects
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
normal variant short stature
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
Turner's syndrome
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
metabolic syndrome
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
maintaining weight loss
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
Attention Deficit Hyperactivity Disorder (ADHD) comorbidities
Poestges, Reiner; Schneider, Bernd; Ammer, Richard
Patent: US2008/75769 A1, 2008 ;
Title/Abstract Full Text Show Details
fatigue
Poestges, Reiner; Schneider, Bernd; Ammer, Richard
Patent: US2008/75769 A1, 2008 ; Title/Abstract Full Text Show Details
cognitive decline associated with systemic diseases
Poestges, Reiner; Schneider, Bernd; Ammer, Richard
Patent: US2008/75769 A1, 2008 ; Title/Abstract Full Text Show Details
acquired immunodeficiency syndrome
Poestges, Reiner; Schneider, Bernd; Ammer, Richard
Patent: US2008/75769 A1, 2008 ; Title/Abstract Full Text Show Details
oncological diseases
Poestges, Reiner; Schneider, Bernd; Ammer, Richard
Patent: US2008/75769 A1, 2008 ; Title/Abstract Full Text Show Details
active ingredient of multimodal abuse resistant pharmaceutical composition
active ingredient of multimodal extended release pharmaceutical composition
active ingredient of multimodal extended release abuse resistant pharmaceutical composition
modulate dopamine receptors; β-PEA analogue
THERAQUEST BIOSCIENCES, INC.
Patent: WO2008/33351 A2, 2008 ; Title/Abstract Full Text Show Details
THERAQUEST BIOSCIENCES, INC.
Patent: WO2008/33351 A2, 2008 ; Title/Abstract Full Text Show Details
THERAQUEST BIOSCIENCES, INC.
Patent: WO2008/33351 A2, 2008 ; Title/Abstract Full Text Show Details
BRAINCELLS, INC.
Patent: WO2008/39863 A2, 2008 ; Title/Abstract Full Text Show Details
Neurogenic agent
BRAINCELLS, INC.
Patent: WO2008/39863 A2, 2008 ; Title/Abstract Full Text Show Details
method of increasing neurogenesis
BRAINCELLS, INC.
Patent: WO2008/39863 A2, 2008 ; Title/Abstract Full Text Show Details
nervous system disorder
BRAINCELLS, INC.
Patent: WO2008/39863 A2, 2008 ; Title/Abstract Full Text Show Details
nerve cell trauma
BRAINCELLS, INC.
Patent: WO2008/39863 A2, 2008 ; Title/Abstract Full Text Show Details
psychiatric condition
BRAINCELLS, INC.
Patent: WO2008/39863 A2, 2008 ; Title/Abstract Full Text Show Details
neurological condition
BRAINCELLS, INC.
Patent: WO2008/39863 A2, 2008 ; Title/Abstract Full Text Show Details
central stimulant drug
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Patent: WO2008/63721 A2, 2008 ; Title/Abstract Full Text Show Details
central nervous system (CNS) stimulant
NEUROGESX, INC.
Patent: WO2008/70149 A2, 2008 ; Title/Abstract Full Text Show Details
Decongestant
CASE WESTERN RESERVE UNIVERSITY
Patent: WO2008/70264 A2, 2008 ; Title/Abstract Full Text Show Details
epilepsy
Tam, Peter Y.; Wilson, Leland F.
Patent: US2008/103179 A1, 2008 ; Title/Abstract Full Text Show Details
diabetes
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
Tam, Peter Y.; Wilson, Leland F.
Patent: US2008/103179 A1, 2008 ; Title/Abstract Full Text Show Details
hypertension
Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su
Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details
Tam, Peter Y.; Wilson, Leland F.
Patent: US2008/103179 A1, 2008 ; Title/Abstract Full Text Show Details
pulmonary hypertension
Tam, Peter Y.; Wilson, Leland F.
Patent: US2008/103179 A1, 2008 ; Title/Abstract Full Text Show Details
migraine
Tam, Peter Y.; Wilson, Leland F.
Patent: US2008/103179 A1, 2008 ; Title/Abstract Full Text Show Details
sleep apnea
Cypress Bioscience, Inc.
Patent: US2006/39866 A1, 2006 ; Title/Abstract Full Text Show Details
Tam, Peter Y.; Wilson, Leland F.
Patent: US2008/103179 A1, 2008 ; Title/Abstract Full Text Show Details
depression
Kirk, Randal J.
Patent: US2006/100136 A1, 2006 ; Title/Abstract Full Text Show Details
Tam, Peter Y.; Wilson, Leland F.
Patent: US2008/103179 A1, 2008 ; Title/Abstract Full Text Show Details
impulse control disorders
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
Tam, Peter Y.; Wilson, Leland F.
Patent: US2008/103179 A1, 2008 ; Title/Abstract Full Text Show Details
alcohol addiction
Tam, Peter Y.; Wilson, Leland F.
Patent: US2008/103179 A1, 2008 ; Title/Abstract Full Text Show Details
sympathomimetic agent
Tam, Peter Y.; Wilson, Leland F.
Patent: US2008/103179 A1, 2008 ;
Title/Abstract Full Text Show Details
second agent of the composition with antiepileptic agent
Tam, Peter Y.; Wilson, Leland F.
Patent: US2008/103179 A1, 2008 ; Title/Abstract Full Text Show Details
second agent of the composition with anticonvulsant sulfamate or sulfonylurea compound
combination with milnacipran for long-term treatment of fatigue
Tam, Peter Y.; Wilson, Leland F.
Patent: US2008/103179 A1, 2008 ; Title/Abstract Full Text Show Details
Cypress Bioscience, Inc.
Patent: US2008/293820 A1, 2008 ; Title/Abstract Full Text Show Details
Norepinephrine transporter
Dopamine Transporter
monoamine transporter
Antiobesity agent
Page/Page column 12
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Patent: WO2008/13997 A2, 2008 ;
Page/Page column 12
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Patent: WO2008/13997 A2, 2008 ;
Page/Page column 12
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Patent: WO2008/13997 A2, 2008 ;
Novo Nordisk, A/S
Patent: US6972294 B1, 2005 ;
Title/Abstract Full Text Show Details
Title/Abstract Full Text Show Details
Title/Abstract Full Text Show Details
Title/Abstract Full Text Show Details
NOVO NORDISK A/S
Patent: WO2007/144394 A2, 2007 ; Title/Abstract Full Text Show Details
active ingredient to reduce appetite
LABORATORIOS DEL DR. ESTEVE, S.A.
Patent: EP1743643 A1, 2007 ; Title/Abstract Full Text Show Details
Laboratorios del Dr. Esteve S.A.
Patent: EP1745783 A1, 2007 ; Title/Abstract Full Text Show Details
Reducing appetite
LABORATORIOS DEL DR. ESTEVE, S.A.
Patent: EP1757588 A1, 2007 ; Title/Abstract Full Text Show Details
Local irritation of the gastrointestinal (GI) tract
PRAECIS PHARMACEUTICALS, INC.
Patent: WO2007/21970 A2, 2007 ; Title/Abstract Full Text Show Details
Reduced food effect
PRAECIS PHARMACEUTICALS, INC.
Patent: WO2007/21970 A2, 2007 ; Title/Abstract Full Text Show Details
Protection of the gastrointestinal tract
PRAECIS PHARMACEUTICALS, INC.
Patent: WO2007/21970 A2, 2007 ; Title/Abstract Full Text Show Details
Reduced irritating effect
PRAECIS PHARMACEUTICALS, INC.
Patent: WO2007/21970 A2, 2007 ; Title/Abstract Full Text Show Details
Taste masking
PRAECIS PHARMACEUTICALS, INC.
Patent: WO2007/21970 A2, 2007 ;
Title/Abstract Full Text Show Details
Odor masking
PRAECIS PHARMACEUTICALS, INC.
Patent: WO2007/21970 A2, 2007 ; Title/Abstract Full Text Show Details
Flavor augmentation
PRAECIS PHARMACEUTICALS, INC.
Patent: WO2007/21970 A2, 2007 ; Title/Abstract Full Text Show Details
Acidic conditions of the gastrointestinal tract
PRAECIS PHARMACEUTICALS, INC.
Patent: WO2007/21970 A2, 2007 ; Title/Abstract Full Text Show Details
Long-term therapy for fibromyalgia syndrome (FMS)
Cypress Bioscience, Inc.
Patent: US2007/72946 A1, 2007 ; Title/Abstract Full Text Show Details
Fibromyalgia
Cypress Bioscience, Inc.
Patent: US2007/72946 A1, 2007 ; Title/Abstract Full Text Show Details
Acute pain
Cypress Bioscience, Inc.
Patent: US2007/72946 A1, 2007 ; Title/Abstract Full Text Show Details
Long-term therapy of a pain symptom associated with fibromyalgia syndrome
Appetite regulating agent
Cypress Bioscience, Inc.
Patent: US2007/72946 A1, 2007 ; Title/Abstract Full Text Show Details
IRM LLC
Patent: WO2007/89557 A2, 2007 ; Title/Abstract Full Text Show Details
IRM LLC
Patent: WO2007/89667 A1, 2007 ; Title/Abstract Full Text Show Details
attention deficit disorders (ADD, also known as attention deficit hyperactivity disorder or ADHD)
cognitive improvement agent
Wyeth
Patent: US2007/225334 A1, 2007 ; Title/Abstract Full Text Show Details
Wyeth
Patent: US2007/225278 A1, 2007 ; Title/Abstract Full Text Show Details
Wyeth
Patent: US2007/225334 A1, 2007 ; Title/Abstract Full Text Show Details
attention deficit disorders/attention Deficit Hyperactivity Disorder (ADD/ADHD) agent
adrenoceptor agonist
Wyeth
Patent: US2007/225278 A1, 2007 ; Title/Abstract Full Text Show Details
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2007/93624 A2, 2007 ; Title/Abstract Full Text Show Details
Attention Deficit Hyperactivity Disorder (ADHD) predominantly impulsivity type
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2007/93624 A2, 2007 ; Title/Abstract Full Text Show Details
Attention Deficit Hyperactivity Disorder (ADHD) predominantly
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER
INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2007/93624 A2, 2007 ;
inattentive type
Title/Abstract Full Text Show Details
Attention Deficit Hyperactivity Disorder (ADHD) predominantly hyperactive-impulsive type
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2007/93624 A2, 2007 ; Title/Abstract Full Text Show Details
Attention Deficit Hyperactivity Disorder (ADHD) predominantly not otherwise specified
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2007/93624 A2, 2007 ; Title/Abstract Full Text Show Details
appetite suppresant; antiobesity agent
GELESIS, INC.
Patent: WO2007/112436 A2, 2007 ; Title/Abstract Full Text Show Details
enhancing gastric retention
GELESIS, INC.
Patent: WO2007/112436 A2, 2007 ; Title/Abstract Full Text Show Details
controlled drug delivery
GELESIS, INC.
Patent: WO2007/112436 A2, 2007 ; Title/Abstract Full Text Show Details
inducing weight loss
GELESIS, INC.
Patent: WO2007/112436 A2, 2007 ; Title/Abstract Full Text Show Details
gastrointestinal disorders
GELESIS, INC.
Patent: WO2007/112436 A2, 2007 ; Title/Abstract Full Text Show Details
Anorexia
Nettekoven, Matthias Heinrich; Roche, Olivier
Patent: US2007/270423 A1, 2007 ; Title/Abstract Full Text Show Details
Antiobesity agent in combination
NOVO NORDISK A/S
Patent: WO2007/135111 A1, 2007 ; Title/Abstract Full Text Show Details
Anti-obesity agent
IRM LLC
Patent: WO2005/113506 A1, 2005 ; Title/Abstract Full Text Show Details
NOVARTIS AG; NOVARTIS PHARMA GmbH
Patent: WO2007/41366 A1, 2007 ; Title/Abstract Full Text Show Details
IRM LLC
Patent: WO2007/89557 A2, 2007 ; Title/Abstract Full Text Show Details
IRM LLC
Patent: WO2007/89667 A1, 2007 ; Title/Abstract Full Text Show Details
IRM LLC
Patent: WO2005/113519 A1, 2005 ; Title/Abstract Full Text Show Details
Anorectic agent
Page/Page column 16
Nettekoven, Matthias; Plancher, Jean-Marc; Richter, Hans; Roche, Oliver; Runtz-Schmitt, Valerie; Taylor, Sven
Patent: US2007/123515 A1, 2007 ; Title/Abstract Full Text Show Details
Anorectic agent
Page/Page column 14
Nettekoven, Matthias; Plancher, Jean-Marc; Richter, Hans; Roche, Olivier; Taylor, Sven
Patent: US2007/123525 A1, 2007 ; Title/Abstract Full Text Show Details
identifying a modulator of N-methyl-D-aspartate (NMDA) receptor function
agent that reduces phosphorylation of an NMDA receptor complex
deCODE Genetics, Inc.
Patent: US2006/29546 A1, 2006 ; Title/Abstract Full Text Show Details
deCODE Genetics, Inc.
Patent: US2006/29546 A1, 2006 ; Title/Abstract Full Text Show Details
stimulant
Renshaw, Perry F.; Cohen, Bruce M.
Patent: US2006/39890 A1, 2006 ; Title/Abstract Full Text Show Details
Kirk, Randal J.
Patent: US2006/100136 A1, 2006 ; Title/Abstract Full Text Show Details
sleep related breathing disorder
Cypress Bioscience, Inc.
Patent: US2006/39866 A1, 2006 ; Title/Abstract Full Text Show Details
therapy
Cypress Bioscience, Inc.
Patent: US2006/39866 A1, 2006 ; Title/Abstract Full Text Show Details
pharmaceutical composition
Cypress Bioscience, Inc.
Patent: US2006/39866 A1, 2006 ; Title/Abstract Full Text Show Details
combination therapy
Cypress Bioscience, Inc.
Patent: US2006/39866 A1, 2006 ; Title/Abstract Full Text Show Details
daytime drowsiness
Cypress Bioscience, Inc.
Patent: US2006/39866 A1, 2006 ; Title/Abstract Full Text Show Details
cause release of norepinephrine
Davis, Michael; Ressler, Kerry J.; Chhatwal, Jasmeer P.; McDevitt, Jason P.
Patent: US2006/84659 A1, 2006 ; Title/Abstract Full Text Show Details
pharmacologic agent increases the level of norepinephrine in the brain
Davis, Michael; Ressler, Kerry J.; Chhatwal, Jasmeer P.; McDevitt, Jason P.
Patent: US2006/84659 A1, 2006 ; Title/Abstract Full Text Show Details
Anoretic agent
Nettekoven, Matthias Heinrich; Plancher, Jean-Marc; Roche, Olivier; Rodriguez-Sarmiento, Rosa Maria
Patent: US2006/160855 A1, 2006 ; Title/Abstract Full Text Show Details
Antiobesity
CENGENT THERAPEUTICS, INC.
Patent: WO2006/78698 A1, 2006 ; Title/Abstract Full Text Show Details
Dopamine agonist
CLERA INC.
Patent: WO2006/84368 A1, 2006 ; Title/Abstract Full Text Show Details
Dopamine mimetic
CLERA INC.
Patent: WO2006/84368 A1, 2006 ;
Title/Abstract Full Text Show Details
Increasing availability of serotonin
THE SILVAN S. TOMKINS INSTITUTE
Patent: WO2006/91725 A1, 2006 ; Title/Abstract Full Text Show Details
Increasing efficiency of serotonin
THE SILVAN S. TOMKINS INSTITUTE
Patent: WO2006/91725 A1, 2006 ; Title/Abstract Full Text Show Details
stimulant effect on the central nervous system
The Research Foundation of the City University of New York; New York University
Patent: US7112319 B2, 2006 ; Title/Abstract Full Text Show Details
Stimulant
The Research Foundation of the City University of New York; New York University
Patent: US7112319 B2, 2006 ; Title/Abstract Full Text Show Details
Psychomotor stimulant
ABBOTT GMBH and CO.KG
Patent: WO2006/40177 A1, 2006 ; Title/Abstract Full Text Show Details
antiobesity agent
NOVO NORDISK A/S
Patent: WO2006/40329 A1, 2006 ; Title/Abstract Full Text Show Details
central-nervous-system stimulant
Kulli, John C.
Patent: US2006/257323 A1, 2006 ; Title/Abstract Full Text Show Details
autism
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
compulsivity
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
impulsivity
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
Asperger's syndrome
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
attention deficit disorder
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
Kirk, Randal J.
Patent: US2006/100136 A1, 2006 ; Title/Abstract Full Text Show Details
attention deficit hyperactivity disorder
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
Kirk, Randal J.
Patent: US2006/100136 A1, 2006 ; Title/Abstract Full Text Show Details
obsessive-compulsive disorder
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
Tourette's syndrome
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
body dismorphic disorder
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
hypochondriasis
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
eating disorders
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
paraphilias sexual addictions
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
nonparaphilic sexual addictions
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
Sydeham's chorea
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
torticollis
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
intermittent explosive disorder
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
kleptomania
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
pathological gambling
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
pyromania
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
compulsive shopping
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
compulsive buying
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
repetitive self-mutilation
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ;
Title/Abstract Full Text Show Details
onychophagia
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
psychogenic excoriation
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
trichotillomania
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
anorexia nervosa
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
binge eating
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
sexual compulsion
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
alcohol and substance use disorders
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
neurological disorders with disinhibition or frontal lobe deficits
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
bipolar disorder
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
childhood onset bipolar disorder
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
serotonin reuptake inhibitor
MOUNT SINAI SCHOOL OF MEDICINE
Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details
Page/Page column 87-88
ABBOTT GMBH and CO. KG
Patent: WO2006/40180 A1, 2006 ;
Page/Page column 32
NOVO NORDISK A/S
Patent: WO2006/120178 A1, 2006 ;
Pharmaceutically active agent in oral osmotic pharmaceutical delivery dosage form
Kidane, Argaw; Ray, Shimul K.; Bhatt, Padmanabh P.; Bryan, Jones W.
Patent: US2005/53653 A1, 2005 ;
active ingredient of pharmaceutical formulation
Psychomotor stimulant
antiobesity agent
Title/Abstract Full Text Show Details
Title/Abstract Full Text Show Details
Title/Abstract Full Text Show Details
RANBAXY LABORATORIES LIMITED
Patent: WO2005/44238 A1, 2005 ; Title/Abstract Full Text Show Details
modulating central norepinephrine and dopamine receptors through the promotion of catecholamine release
PFIZER PRODUCTS INC.
Patent: WO2005/61506 A1, 2005 ; Title/Abstract Full Text Show Details
PFIZER PRODUCTS INC.
Patent: WO2005/61507 A1, 2005 ; Title/Abstract Full Text Show Details
Adrenergic agent
PFIZER PRODUCTS INC.
Patent: WO2005/61506 A1, 2005 ; Title/Abstract Full Text Show Details
PFIZER PRODUCTS INC.
Patent: WO2005/61507 A1, 2005 ; Title/Abstract Full Text Show Details
Type 2 diabetes mellitus
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Insulin resistance
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Syndrome X
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Hypertension including hypertension in the elderly
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Familial dyslipidemic hypertension
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Isolated systolic hypertension(ISH)
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Increased collagen formation
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Fibrosis
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Remodeling following hypertension
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Erectile dysfunction
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Impaired vascular compliance
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Stroke
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
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Congestive heart failure
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Left ventricular hypertrophy
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Survival post myocardial infarction(MI)
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Coronary artery diseases
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Atherosclerosis
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Angina pectoris
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Thrombosis
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Renal failure
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Chronic renal failure
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Glomerulosclerosis
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Nephropathy
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Hypothyroidism
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Endothelial dysfunction with or without hypertension
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Hyperlipidemia
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Hyperlipoproteinemia
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Hypertryglyceridemia
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Hypercholesterolemia
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Macular degeneration
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Cataract
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Glaucoma
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Skin and connective tissue disorders
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Restenosis after percutaneous transluminal angioplasty
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Restenosis after coronary artery bypass surgery
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Peripheral vascular disease
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Reproductive disorders
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Pulmonary disease
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Gallstones
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Fasting-inducedcholecystitis
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Cancers
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Cutaneous disease
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Cushing's syndrome
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Insulinoma
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Craniopharyngioma
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
Premenstrual syndrome
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
dopamine releaser
DESCARTES THERAPEUTICS, INC.
Patent: WO2005/107467 A2, 2005 ; Title/Abstract Full Text Show Details
Dopaminergic agent for composition for treating pain
DESCARTES THERAPEUTICS, INC.
Patent: WO2005/107467 A2, 2005 ; Title/Abstract Full Text Show Details
Dopaminergic agent for composition for treating nociception
DESCARTES THERAPEUTICS, INC.
Patent: WO2005/107467 A2, 2005 ; Title/Abstract Full Text Show Details
inflammation and discomfort within the nasal passages or throat
Wasson, Allan Anthony
Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details
laryngitis
Wasson, Allan Anthony
Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details
tracheitis
Wasson, Allan Anthony
Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details
nasal secretions
Wasson, Allan Anthony
Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details
watery eyes
Wasson, Allan Anthony
Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details
cough
Wasson, Allan Anthony
Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details
tracheobroncheal involvement
Wasson, Allan Anthony
Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details
pneumonia
Wasson, Allan Anthony
Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details
viral allergies
Wasson, Allan Anthony
Patent: US2005/277697 A1, 2005 ;
Title/Abstract Full Text Show Details
flu-like or viral infection
Wasson, Allan Anthony
Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details
adverse effects of an air-born allergen
Wasson, Allan Anthony
Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details
bronchitis
Wasson, Allan Anthony
Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details
runny nose
Wasson, Allan Anthony
Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details
sneezing
Wasson, Allan Anthony
Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details
viral-induced malaise
Wasson, Allan Anthony
Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details
Obesity
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details
SEED, John, C.
Patent: WO2005/51297 A2, 2005 ; Title/Abstract Full Text Show Details
Achieving desirable weight loss
SEED, John, C.
Patent: WO2005/51297 A2, 2005 ; Title/Abstract Full Text Show Details
Overweight
SEED, John, C.
Patent: WO2005/51297 A2, 2005 ; Title/Abstract Full Text Show Details
Preventing undesirable weight gain
SEED, John, C.
Patent: WO2005/51297 A2, 2005 ; Title/Abstract Full Text Show Details
Reducing body weight
SEED, John, C.
Patent: WO2005/51297 A2, 2005 ; Title/Abstract Full Text Show Details
Maintaining stable weight
SEED, John, C.
Patent: WO2005/51297 A2, 2005 ; Title/Abstract Full Text Show Details
Depression
SEED, John, C.
Patent: WO2005/51297 A2, 2005 ; Title/Abstract Full Text Show Details
Alzheimer's disease
SEED, John, C.
Patent: WO2005/51297 A2, 2005 ; Title/Abstract Full Text Show Details
Anorexiant
SEED, John, C.
Patent: WO2005/51297 A2, 2005 ; Title/Abstract Full Text Show Details
active drug for pharmaceutical drug resin conjugate
Thassu, Deepak; Hafey, Paul
Patent: US2005/142097 A1, 2005 ; Title/Abstract Full Text Show Details
biologically active agent for preparation of hydroxyalkyl derivatives with improved bioavailability, bioefficacy and reduced side effects
KOPRAN RESEARCH LABORATORIES LIMITED
Patent: WO2005/105153 A1, 2005 ; Title/Abstract Full Text Show Details
Appetite-regulating agent
IRM LLC
Patent: WO2005/113506 A1, 2005 ; Title/Abstract Full Text Show Details
IRM LLC
Patent: WO2005/113519 A1, 2005 ; Title/Abstract Full Text Show Details