1-Phenylpropan-2-amine (Amphetamine)

Page 1

Reaxys

PubChem

eMolecules

Reactions (599)

Substances (1)

Citations (1763)

Structure

Structure/Compound Data Chemical Name: 2-amino-1-phenylpropane Reaxys Registry Number: 507867

CAS Registry Number: 60-15-1, 156-34-3, 51-64-9, 300-62-9 Type of Substance: isocyclic Molecular Formula: C9H13N Linear Structure Formula: C6H5CH2CH(CH3)NH2

Molecular Weight: 135.209 InChI Key: KWTSXDURSIMDCE-UHFFFAOYSA-N

1

Synthesize | Hide Details Find similar Chemical Names and Synonyms 2-amino-1-phenylpropane, AMPHETAMINE Identification Substance Label (32) Label

Reference

c

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AMPH

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N° of preparations All Preps | All Reactions 84 prep out of 599 reactions.

Available Data

N° of ref.

Identification Physical Data (113) Spectra (81) Bioactivity (317) Other Data (299)

1763


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1

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amph

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15

Jat, Jawahar L.; Paudyal, Mahesh P.; Gao, Hongyin; Xu, Qing-Long; Yousufuddin, Muhammed; Devarajan, Deepa; Ess, Daniel H.; Kurti, Laszlo; Falck, John R.

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ESS, Daniel, Halsell; FALCK, John, Russell; JAT, Jawahar, Lal; URTI, Laszlo

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(±)-7b

Martínez-Montero, Lía; Díaz-Rodríguez, Alba; Gotor, Vicente; Gotor-Fernández, Vicente; Lavandera, Iván

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12a

Rodríguez, Anna; Guerrero, Angel; Gutierrez-De-Terán, Hugo; Rodríguez, David; Brea, José; Loza, María I.; Rosell, Gloria; Pilar Bosch

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Amphetamine

Cheng, Jianjun; Giguère, Patrick M.; Onajole, Oluseye K.; Lv, Wei; Gaisin, Arsen; Gunosewoyo, Hendra; Schmerberg, Claire M.; Pogorelov, Vladimir M.; Rodriguiz, Ramona M.; Vistoli, Giulio; Wetsel, William C.; Roth, Bryan L.; Kozikowski, Alan P.

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37

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rac-9

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AM

Nakahara, Yuji; Kikura, Ruri

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Bach, Mimi V.; Coutts; Baker

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Amp

Danaceau, Jonathan P.; Deering, Cassandra E.; Day, Jayme E.; Smeal, Stacy J.; Johnson-Davis, Kamisha L.; Fleckenstein, Annette E.; Wilkins, Diana G.

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tab. 1, entry 2, prod.

Ankner, Tobias; Hilmersson, Goeran

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9

Nechab, Malek; Azzi, Nadia; Vanthuyne, Nicolas; Bertrand, Michele; Gastaldi, Stephane; Gil, Gerard

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Amph

Zurita, Alejandra; Muru, Sergio; Molina, Victor

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Prieto-Gomez; Vazquez-Alvarez; Martinez-Pena; Reyes-Vazquez; Yang; Dafny

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R-NH2, f

Oikawa, Masato; Ikoma, Minoru; Sasaki, Makoto

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11m

Guisado, Cristina; Waterhouse, Jodie E.; Price, Wayne S.; Jorgensen, Michael R.; Miller, Andrew D.

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AP

Kikura; Nakahara

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Cirimele; Kintz; Mangin

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Sekine, Hitoshi; Nagao, Shigeyuki; Nakahara, Yuji

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Pichini, Simona; Pacifici, Roberta; Pellegrini, Manuela; Marchei, Emilia; Lozano, Jaime; Murillo, Janeth; Vall, Oriol; Garcia-Algar, Oscar

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III

Guranda; Shapovalova; Svedas

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7

Li, Yanjun; Izumi, Taeko

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Reference

3

Nagy, Peter I.; Alagona, Giuliano; Ghio, Caterina; Takacs-Novak, Krisztina

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(+/-)-1

Gonzalez-Sabin, Javier; Gotor, Vicente; Rebolledo, Francisca

Tetrahedron Asymmetry, 2002 , vol. 13, # 12 p. 1315 - 1320


Title/Abstract Full Text View citing articles Show Details

(+/-)-7

Pallavicini, Marco; Bolchi, Cristiano; Fumagalli, Laura; Valoti, Ermanno; Villa, Luigi

Tetrahedron Asymmetry, 2002 , vol. 13, # 20 p. 2277 - 2282 Title/Abstract Full Text View citing articles Show Details

4

Li, Yanjun; Izumi, Taeko

Journal of the Chinese Chemical Society (Taipei, Taiwan), 2002 , vol. 49, # 4 p. 505 - 508 Title/Abstract Full Text View citing articles Show Details

AMPH; A

Kantor, Lana; Park, Yang Hae; Wang, Kevin K.W; Gnegy, Margaret E

European Journal of Pharmacology, 2002 , vol. 451, # 1 p. 27 - 35 Title/Abstract Full Text View citing articles Show Details

f'

Bansal, Ekta; Srivastava; Kumar, Ashok

European Journal of Medicinal Chemistry, 2001 , vol. 36, # 1 p. 81 - 92 Title/Abstract Full Text View citing articles Show Details

8, T2, entry I

Subramanyam

Tetrahedron Letters, 2000 , vol. 41, # 34 p. 6537 - 6540 Title/Abstract Full Text View citing articles Show Details

27

Dowd; Herrick-Davis; Egan; DuPre; Smith; Teitler; Glennon

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4b

Haak, Edgar; Siebeneicher, Holger; Doye, Sven

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5a

Kinbara, Kazushi; Harada, Yoshiko; Saigo, Kazuhiko

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9a

Gyenes, Ferenc; Bergmann, Kathryn E.; Welch, John T.

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V

Markaryan; Airapetyan; Mikaelyan; Asatryan; Noravyan

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Patent-Specific Data (3)

Prophetic Compound

Related Markush Structure (RN)

Reference

20353528

Johnson Matthey Public Limited Company

Patent: US2010/125146 A1, 2010 ; Title/Abstract Full Text Show Details

19815298

Yamakawa Chemical Industry Co., Ltd.

Patent: US6342636 B1, 2002 ; Title/Abstract Full Text Show Details

prophetic product

Sumitomo Chemical Company, Limited

Patent: US4698421 A1, 1987 ;

Title/Abstract Full Text Show Details

Related Structure (2) Related Structure

Reference

Yamada et al.

Tetrahedron Letters, 1976 , p. 1001 Full Text View citing articles Show Details

Configuration.

Karrer; Ehrhardt

Helvetica Chimica Acta, 1951 , vol. 34, p. 2202,2208 Full Text Show Details

Schrecker

Journal of Organic Chemistry, 1957 , vol. 22, p. 33 Full Text View citing articles Show Details


Cervinka et al.

Zeitschrift fuer Chemie (Stuttgart, Germany), 1968 , vol. 8, p. 24 Full Text Show Details

Derivative (41) Derivative

Comment (Derivative)

Reference

amphetamine hydrochloride

Kabalka, George W.; Laila Guindi; Varma, Rajender S.

Tetrahedron, 1990 , vol. 46, # 21 p. 7443 - 7457 Title/Abstract Full Text View citing articles Show Details

amphetamine hydrochloride

Jilek, Jiri; Urban, Jiri; Taufmann, Petr; Holubek, Jiri; Dlabac, Antonin; et al.

Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 7 p. 1995 - 2008 Title/Abstract Full Text Show Details

(1-Methyl-2-phenylethyl)trimethylsilanylamine

Rucker; Neugebauer; Heiden

Arzneimittel-Forschung/Drug Research, 1988 , vol. 38, # 4 p. 497 - 501 Title/Abstract Full Text View citing articles Show Details

Sulfat (I): Spektrofluorometrische Bestimmung mit Fluorescamin; Luminescenzeigenschaften; Fluorescenzkurve (pH-Abhaengigkeit)

De Silva; Strojny

Analytical Chemistry, 1975 , vol. 47, p. 714,716, 718 Full Text View citing articles Show Details

Pikrolonat: F: 175-178grad

Kuhnert-Brandstaetter et al.

Pharmaceutica Acta Helvetiae, 1975 , vol. 50, p. 360,364 Full Text Show Details

Pikrolonat: F: 185-188grad

Kuhnert-Brandstaetter et al.

Pharmaceutica Acta Helvetiae, 1975 , vol. 50, p. 360,364 Full Text Show Details

Sulfat: F: 260-275grad; UV; λ(max); ε; Zers.: 300-320grad in Silicagel; eutektische Temperatur mit Saccharin: 180grad: eutektische Temperatur mit Phenolphthalein: 219grad

Kuhnert-Brandstaetter et al.

Pharmaceutica Acta Helvetiae, 1975 , vol. 50, p. 360,364 Full Text Show Details

Sulfat: F: 285-310grad; UV; λ(max); ε; eutektische Temperatur mit Phenolphthalein: 232grad: eutektische Temperatur mit 4-Sulfamoylbenzoesaeure: 233grad; eutektische Temperatur mit Dicyandiamid: 165grad

Kuhnert-Brandstaetter et al.

Pharmaceutica Acta Helvetiae, 1975 , vol. 50, p. 360,364 Full Text Show Details

Acetylderivat : F:90-92grad

Landor et al.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1974 , p. 1294,1299 Full Text Show Details

Komplex: Amphet(?)aminsulfat*FMN; Abs.-Sp., K

Sung; Parker

Zeitschrift fuer Naturforschung, C: Journal of Biosciences, 1974 , vol. 29, p. 122,124 Full Text Show Details

Hexafluoroacetonaddukt : 19F-NMR

Leader

Analytical Chemistry, 1973 , vol. 45, p. 1700,1706 Full Text Show Details

Bisulfat-Salz: λ(ex), λ(em) fuer Fluoreszenz und Phosphoreszenz, rel. Quantenwirksamkeit in 0,1 n wss. H2SO4 in Ggw. von Luft

Miles; Schenk

Analytical Chemistry, 1973 , vol. 45, p. 130,132 Full Text Show Details

Sulfat: IR

Blang; Huang

Journal of Pharmaceutical Sciences, 1973 , vol. 62, p. 652 Full Text View citing articles Show Details

Blang; Huang

Journal of Pharmaceutical Sciences, 1972 , vol. 61, p. 1770,1772, 1774 Full Text View citing articles Show Details


Hydrochlorid: aus der unmarkierten Verbindung mit tritiierter Phosphorsaeure*BF3 nach der Methode von Yavorsky, Gorin, J. Am. Chem. Soc. 84<1962>1071

Telc et al.

Journal of Labelled Compounds, 1972 , vol. 8, p. 13,14, 19 Full Text Show Details

als N,N-Bis-trifluoracetyl-Derivat

Ehrsson; Broetel

Acta Pharmaceutica Suecica, 1971 , vol. 8, p. 591,596 Full Text Show Details

als N,N-Bis-heptafluorbutyl-Derivat

Ehrsson; Broetel

Acta Pharmaceutica Suecica, 1971 , vol. 8, p. 591,596 Full Text Show Details

H2SO4-Salz: Kristallstruktur

Bergin; Carlstroem

Acta Crystallographica, Section B: Structural Crystallography and Crystal Chemistry, 1971 , vol. 27, p. 2146,2151 Full Text Show Details

*H2SO4: 1H-NMR; IR-Spektrum; UV; pK

Warren et al.

Journal - Association of Official Analytical Chemists, 1971 , vol. 54, p. 1179,1181,1186,1188 Full Text View citing articles Show Details

Hydrochlorid C9H14ClN: NMR-Daten (Tab.I); Rotameren-Verteilg. (Fig.2)

Neville et al.

Journal of Medicinal Chemistry, 1971 , vol. 14, p. 717,718 Full Text Show Details

Sulfat: Rk. mit 2,5-Dimethoxytetrahydrofuran, p-(Dimethylamino)-benzaldehyd (Photometr. Messung, Ext. Max.)

Fontani; Morandini

The Journal of pharmacy and pharmacology, 1970 , vol. 22, # 6 p. 411 - 413 Title/Abstract Full Text View citing articles Show Details

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Comment (Derivative)

Reference

Hydrochlorid, pK(a): 9.07

Garrett, Chembarkar

Journal of Pharmaceutical Sciences, 1968 , vol. 57, p. 1401,1402 Full Text Show Details

Hydrochlorid: B: aus 1-Chlor-1-phenyl-2-amino-propan-Hydrochlorid, H2 <Pd-C>

Kotera,K. et al.

Tetrahedron, 1968 , vol. 24, p. 5677 - 5690 Full Text View citing articles Show Details

Salz m. Na2SO3: B.; λ(max); ν(max)

Griffin; Banker

Journal of Pharmaceutical Sciences, 1967 , vol. 56, p. 1098,1099 Full Text Show Details

Salz m. Mannose-sulfonat: B.; λ(max); ν(max)

Griffin; Banker

Journal of Pharmaceutical Sciences, 1967 , vol. 56, p. 1098,1099 Full Text Show Details

Salz m. Glucose-sulfonat; B., P. (v. Mannose-Verb.)

Griffin; Banker

Journal of Pharmaceutical Sciences, 1967 , vol. 56, p. 1098,1099 Full Text Show Details

Hydrochlorid: Rkt. mit 1. Benzaldehyd od. Anisaldehyd; 2. KCN --> N-(β-Phenyl-isopropyl)-α-amino-phenylessigsaeurenitril bzw. N-(β-Phenyl-isopropyl)-α-amino-p-methoxy-phenylessigsaeurenitril-Hydrochlorid

Kholodov,L.E. et al.

Zhurnal Organicheskoi Khimii, 1967 , vol. 3, # 8 p. 1513 - 1518,1470 - 1474 Full Text View citing articles Show Details

Sulfat C9H13N*H2SO4. UV-max. < MeOH >.

Kracmar; Kracmarova

Cesko-Slovenska Farmacie, 1966 , vol. 15, p. 16,18 Full Text Show Details

H2SO4*: IR-Spectrum

Hayden et al.

Journal - Association of Official Analytical Chemists, 1966 , vol. 49, p. 1109,1119 Full Text Show Details


Sulfat: λ(max), Tab. II

Sinsheimer; Keuhnelian

Journal of pharmaceutical sciences, 1966 , vol. 55, # 11 p. 1240 - 1244 Title/Abstract Full Text View citing articles Show Details

Cyclohexylsulfamidsaeure-Salz. C9H13N*C6H13NO3S. B. aus DL-1-Phenyl-2-amino-propan u. Cyclohexylsulfamidsaeure in Acn. od.Me. F:130grad(aus A. + Ae.)

Sciortino

Bollettino Chimico Farmaceutico, 1966 , vol. 105, p. 223,224 Full Text Show Details

Sulfat: ν(max), Tab. I

Thompson,W.E. et al.

Journal of Pharmaceutical Sciences, 1965 , vol. 54, p. 1819 - 1821 Full Text View citing articles Show Details

Succinat. C9H13N*C4H6O4. Krist. aus Acetonitril. F:162-163grad(korr.).

ELSLAGER; WEINSTEIN; WORTH

Journal of medicinal chemistry, 1964 , vol. 7, p. 493 - 500 Title/Abstract Full Text View citing articles Show Details

Succinat. B. aus 1-<2-Diaethylamino-aethyl>-2-<1-phenyl-2-propyl>-hydrazin u. Bernsteinsaeure in Acn.

ELSLAGER; WEINSTEIN; WORTH

Journal of medicinal chemistry, 1964 , vol. 7, p. 493 - 500 Title/Abstract Full Text View citing articles Show Details

Hydrochlorid: IR-Spektrum

Brannon; Hayden

Journal of the Association of Official Agricultural Chemists, 1964 , vol. 47, p. 918,927 Full Text Show Details

Oxalat 2<C9H13N>*C2H2O4. mp: 237-238grad < nach Hershberg; korr.; EtOH >; IR-Bande < Nujol >: 6.28-6.67μ

Nace; King

Journal of Medicinal and Pharmaceutical Chemistry, 1962 , vol. 5, p. 1316,1321 Full Text Show Details

Benzoyl-Derivat. mp: 132-133grad.

Bose; Raychaudhuri

Journal of the Indian Chemical Society, 1961 , vol. 38, p. 217,219 Full Text Show Details

Sulfat: F:260-275grad, eutekt.Temp.

Brandstaetter-Kuhnert et al.

Scientia Pharmaceutica, 1960 , vol. 28, # 1 p. 7,8-15 Chem.Abstr., 1960 , # 17802 Full Text Show Details

Reineckat; Zers.: 132grad; Loeslichk.; ε

Kum-Tatt

Journal of Pharmacy and Pharmacology, 1960 , vol. 12, p. 666 Full Text Show Details

Addukt m.N-Acetylmethionin, aus den Komponenten, F:148grad

Soc. Chim. Org. Biol.

Patent: FRM79 , 1960 ; Chem.Abstr., 1963 , vol. 58, # 10302g Full Text Show Details

Reineckat. mp:132grad < Zers.>; Loeslichkeit in H2O bei 5grad u. 27grad( Tab. I )

Kum-Tatt

Journal of Pharmacy and Pharmacology, 1960 , vol. 12, p. 666 Full Text Show Details

Sulfat. F:260-275grad. Schmelz-Verh. Eutekt. Temp. mit Salophen;190grad, mit Dicyandiamid: 163grad(156grad inst.)

Brandstaetter-Kuhnert et al.

Scientia Pharmaceutica, 1960 , vol. 28, # 1 p. 7,8-15 Chem.Abstr., 1960 , # 17802 Full Text Show Details

Physical Data Melting Point (1) Reference


Gal et al.

Acta Pharmaceutica Suecica, 1977 , vol. 14, p. 335,340 Full Text Show Details

Boiling Point (18) Boiling Point

Pressure (Boiling Point)

Reference

45 °C

0.5 Torr

Gonzalez-Sabin, Javier; Gotor, Vicente; Rebolledo, Francisca

Tetrahedron Asymmetry, 2002 , vol. 13, # 12 p. 1315 - 1320 Title/Abstract Full Text View citing articles Show Details

102 °C

16 Torr

Li, Yanjun; Izumi, Taeko

Journal of the Chinese Chemical Society (Taipei, Taiwan), 2002 , vol. 49, # 4 p. 505 - 508 Title/Abstract Full Text View citing articles Show Details

81 - 86 °C

10 - 12 Torr

Smith, Roger A.; White, Robert L.; Krantz, Allen

Journal of Medicinal Chemistry, 1988 , vol. 31, # 8 p. 1558 - 1566 Title/Abstract Full Text View citing articles Show Details

102 - 104 °C

22 Torr

Woodruff; Conger

Journal of the American Chemical Society, 1938 , vol. 60, p. 465 Full Text View citing articles Show Details

Abignente; Biniecka Picazio

Acta Poloniae Pharmaceutica - Drug Research, 1977 , vol. 34, # 3 p. 241 - 244 Title/Abstract Full Text View citing articles Show Details

44 °C

0.3 Torr

Neville et al.

Journal of Medicinal Chemistry, 1971 , vol. 14, p. 717,718 Full Text Show Details

120 - 130 °C

20 Torr

Kotera,K. et al.

Tetrahedron, 1968 , vol. 24, p. 5677 - 5690 Full Text View citing articles Show Details

83 °C

10 Torr

Cervinka,O. et al.

Collection of Czechoslovak Chemical Communications, 1968 , vol. 33, p. 3551 - 3557 Full Text View citing articles Show Details

77 - 78 °C

9 Torr

Kindler,K.; Luehrs,K.

Justus Liebigs Annalen der Chemie, 1967 , vol. 707, p. 26 - 34 Full Text View citing articles Show Details

91 - 93 °C

17 Torr

Prajsnar

Zeszyty Naukowe Politechniki Slaskiej, Chemia, 1963 , vol. 20, p. 1,72 Full Text Show Details

99 °C

20 Torr

Christol et al.

Bulletin de la Societe Chimique de France, 1961 , p. 2317 Full Text Show Details

74 °C

8 Torr

Biel et al.

Journal of the American Chemical Society, 1959 , vol. 81, p. 2805,2810, 2813 Full Text View citing articles Show Details

197 - 198 °C

750 Torr

Kornblum; Iffland

Journal of the American Chemical Society, 1949 , vol. 71, p. 2137,2138,2140 Full Text View citing articles Show Details

91 °C

15 Torr

Kornblum; Iffland

Journal of the American Chemical Society, 1949 , vol. 71, p. 2137,2138,2140 Full Text View citing articles Show Details

80 °C

10 Torr

Haskelberg

Journal of the American Chemical Society, 1948 , vol. 70, p. 2811 Full Text View citing articles Show Details

205 °C

Hey

Journal of the Chemical Society, 1930 , p. 18,20 Full Text Show Details

Jaeger; van Dijk

Proceedings of the Koninklijke Nederlandse Akademie van Wetenschappen, Series B: Physical Sciences, 1941 , vol. 44, p. 26,36,37 Full Text Show Details

63 - 64 °C

7 Torr

Jaeger; van Dijk

Proceedings of the Koninklijke Nederlandse Akademie van Wetenschappen, Series B: Physical Sciences, 1941 , vol. 71, p. 26,27


Full Text Show Details

90 °C

20 Torr

Couturier

Annales de Chimie (Cachan, France), 1938 , vol. <11> 10, p. 559,597 Full Text Show Details

203 °C

Edeleanu

Chemische Berichte, 1887 , vol. 20, p. 618 Full Text Show Details

Refractive Index (3) Refractive Index

Wavelength (Refractive Index)

Temperature (Refractive Index)

Reference

1.5175

589 nm

20 °C

Hoek et al.

Recueil des Travaux Chimiques des Pays-Bas, 1966 , vol. 85, p. 1039,1043 Full Text Show Details

1.5179

589 nm

20 °C

Biel et al.

Journal of the American Chemical Society, 1959 , vol. 81, p. 2805,2810, 2813 Full Text View citing articles Show Details

1.5185

589 nm

20 °C

Kornblum; Iffland

Journal of the American Chemical Society, 1949 , vol. 71, p. 2137,2138,2140 Full Text View citing articles Show Details

Density (1) Density

Measurement Temperature

Reference

0.937 g·cm-3

18 °C

Jaeger; van Dijk

Proceedings of the Koninklijke Nederlandse Akademie van Wetenschappen, Series B: Physical Sciences, 1941 , vol. 71, p. 26,27 Full Text Show Details

Adsorption (MCS) (1) Description (Adsorption (MCS))

Reference

Adsorption

Zapior; Czapkiewicz

Roczniki Chemii, 1962 , vol. 36, p. 1863,1866,1867 Chem.Abstr., vol. 58, # 11986 Full Text Show Details

Association (MCS) (10) Description (Association (MCS))

Partner (Association (MCS))

Solvent (Association (MCS))

Temperature (Association (MCS))

NMR spectrum of the complex

2A,2B,2C,2D,2E,2F,2G,3A,3B,3C,3D,3E,3F,3Gtetradeca-O-acetyl-β-cyclodextrin

D2O

26 °C

Thunhorst, Martin; Holzgrabe, Ulrike

Magnetic Resonance in Chemistry, 1998 , vol. 36, # 3 p. 211 216 Title/Abstract Full Text View citing articles Show Details

NMR spectrum of the complex

t-butylphenylphosphinothioic acid

CDCl3

Omelanczuk, Jan; Mikolajczyk, Marian

Tetrahedron Asymmetry, 1996 , vol. 7, # 9 p. 2687 - 2694 Title/Abstract Full Text View citing articles Show Details

Stability constant of the complex with ...

melanin

dimethylsulfoxide aq. phosphate buffer

36 °C

Nakahara; Takahashi; Kikura

Biological and Pharmaceutical Bulletin, 1995 , vol. 18, # 9 p. 1223 - 1227 Title/Abstract Full Text View citing articles Show Details

Stability constant of the complex with ...

H2O

dibutyl ether

21 °C

Tsai, Ruey-Shiuan; Fan, Weizheng; El Tayar, Nabil; Carrupt, Pierre-Alain; Testa, Bernard; Kier, Lemont B.

Journal of the American Chemical Society, 1993 , vol. 115, # 21 p. 9632 - 9639 Title/Abstract Full Text View citing articles Show Details

NMR spectrum of the complex

ethenetetracarbonitrile

Meincke; Kottke; Beyrich

Pharmazie, 1992 , vol. 47, # 9 p. 697 - 699 Title/Abstract Full Text View citing articles Show Details

Association with

iodine

CHCl3

Meincke; Kottke; Beyrich

Reference


compound

Pharmazie, 1992 , vol. 47, # 10 p. 780 - 783 Title/Abstract Full Text View citing articles Show Details

Association with compound

iodine

CCl4

Meincke; Kottke; Beyrich

Pharmazie, 1992 , vol. 47, # 10 p. 780 - 783 Title/Abstract Full Text View citing articles Show Details

Association with compound

iodine

octane

Meincke; Kottke; Beyrich

Pharmazie, 1992 , vol. 47, # 10 p. 780 - 783 Title/Abstract Full Text View citing articles Show Details

NMR spectrum of the complex

(S,S)(-)-1,6-bis-(o-chlorophenyl)-1,6diphenylhexa-2,4-diyne-1,6-diol

Toda, Fumio; Mori, Koji; Okada, Jyoji; Node, Manabu; Itoh, Akichika; et al.

Chemistry Letters, 1988 , p. 131 - 134 Title/Abstract Full Text Show Details

NMR spectrum of the complex

(S)-1,1'-bi-2-naphthol

Toda, Fumio; Mori, Koji; Okada, Jyoji; Node, Manabu; Itoh, Akichika; et al.

Chemistry Letters, 1988 , p. 131 - 134 Title/Abstract Full Text Show Details

Boundary Surface Phenomena (MCS) (1) Description (Boundary Surface Phenomena (MCS))

Reference

Surface tension

Zapior; Czapkiewicz

Roczniki Chemii, 1962 , vol. 36, p. 1863,1866,1867 Chem.Abstr., vol. 58, # 11986 Full Text Show Details

Chromatographic Data (5) Chromatographic data

Location

Reference

GC (Gas chromatography)

Malekzadeh, Hanieh; Fatemi, Mohammad H.

Bulletin of the Chemical Society of Japan, 2015 , vol. 88, # 5 p. 706 - 712 Title/Abstract Full Text View citing articles Show Details

Robayo, Diego A. Sánchez; Mendez, William F. Garzón; Ocampo, Gonzalo Taborda; Moreano, Milton Rosero

Journal of the Brazilian Chemical Society, 2016 , vol. 27, # 6 p. 992 - 997 Title/Abstract Full Text View citing articles Show Details

Ademiluyi, Adedayo O.; Ogunsuyi, Opeyemi B.; Oboh, Ganiyu

NeuroToxicology, 2016 , vol. 56, p. 107 - 117 Title/Abstract Full Text View citing articles Show Details

TLC (Thin layer chromatography)

Noreen; Farman

Asian Journal of Chemistry, 2016 , vol. 28, # 5 p. 1007 - 1010 Title/Abstract Full Text View citing articles Show Details

LC (Liquid chromatography)

Fedorova, Ganna; Randak, Tomas; Lindberg, Richard H.; Grabic, Roman

Rapid Communications in Mass Spectrometry, 2013 , vol. 27, # 15 p. 1751 - 1762 Title/Abstract Full Text View citing articles Show Details

Spinner; Klima; Kempf; Huppertz; Auwärter; Altenburger; Neukamm

Journal of Mass Spectrometry, 2014 , vol. 49, # 12 p. 1306 - 1313 Title/Abstract Full Text View citing articles Show Details

Jeong, Eun Sook; Kim, So-Hee; Cha, Eun-Ju; Lee, Kang Mi; Kim, Ho Jun; Lee, Sang-Won; Kwon, OhSeung; Lee, Jaeick

Rapid Communications in Mass Spectrometry, 2015 , vol. 29, # 4 p. 367 - 384 Title/Abstract Full Text View citing articles Show Details

Jeong, Eun Sook; Kim, So-Hee; Cha, Eun-Ju; Lee, Kang Mi; Kim, Ho Jun; Lee, Sang-Won; Kwon, OhSeung; Lee, Jaeick

Rapid Communications in Mass Spectrometry, 2015 , vol. 29, # 4 p. 367 - 384 Title/Abstract Full Text Show Details

GC (Gas chromatography)

supporting information

Martínez-Montero, Lía; Díaz-Rodríguez, Alba; Gotor, Vicente; Gotor-Fernández, Vicente; Lavandera, Iván

Green Chemistry, 2015 , vol. 17, # 5 p. 2794 - 2798 Title/Abstract Full Text View citing articles Show Details

UPLC (Ultra performance liquid chromatography)

Lin, Huei-Ru; Liao, Chao-Chuan; Lin, Tzu-Chieh

Rapid Communications in Mass Spectrometry, 2014 , vol. 28, # 19 p. 2043 - 2053 Title/Abstract Full Text View citing articles Show Details

Circular Dichroism (1) Reference


Ruckpaul et al.

Croatica Chemica Acta, 1977 , vol. 49, p. 339,343 Full Text Show Details

Conformation (1) Object of Investigation

Reference

Conformation

Pullman et al.

Journal of Medicinal Chemistry, 1972 , vol. 15, p. 17,20 Full Text Show Details

Neville et al.

Journal of Medicinal Chemistry, 1971 , vol. 14, p. 717,718 Full Text Show Details

Kumbar

Journal of Medicinal Chemistry, 1976 , vol. 19, p. 1232,1234 Full Text Show Details

El-Torki, Farid M.; Jacobus John

Journal of Organic Chemistry, 1985 , vol. 50, # 8 p. 1314 - 1316 Title/Abstract Full Text View citing articles Show Details

Crystal Property Description (6) Colour & Other Properties

Location

Reference

colourless

supporting information

Hong, Kai; Liu, Xun; Morken, James P.

Journal of the American Chemical Society, 2014 , vol. 136, # 30 p. 10581 - 10584 Title/Abstract Full Text View citing articles Show Details

Martínez-Montero, Lía; Díaz-Rodríguez, Alba; Gotor, Vicente; Gotor-Fernández, Vicente; Lavandera, Iván

Green Chemistry, 2015 , vol. 17, # 5 p. 2794 - 2798 Title/Abstract Full Text View citing articles Show Details

colourless

Schulze, Matthias

Synthetic Communications, 2010 , vol. 40, # 10 p. 1461 - 1476 Title/Abstract Full Text View citing articles Show Details

white

Collins, Michael; Salouros, Helen; Cawley, Adam T.; Robertson, James; Heagney, Aaron C.; Arenas-Queralt, Andrea

Rapid Communications in Mass Spectrometry, 2010 , vol. 24, # 11 p. 1653 - 1658 Title/Abstract Full Text View citing articles Show Details

orange

Vahermo, Mikko; Suominen, Tina; Leinonen, Antti; Yli-Kauhaluoma, Jari

Archiv der Pharmazie, 2009 , vol. 342, # 4 p. 201 - 209 Title/Abstract Full Text View citing articles Show Details

yellow

Guisado, Cristina; Waterhouse, Jodie E.; Price, Wayne S.; Jorgensen, Michael R.; Miller, Andrew D.

Organic and Biomolecular Chemistry, 2005 , vol. 3, # 6 p. 1049 - 1057 Title/Abstract Full Text View citing articles Show Details

light-brown

Li, Yanjun; Izumi, Taeko

Journal of the Chinese Chemical Society (Taipei, Taiwan), 2002 , vol. 49, # 4 p. 505 - 508 Title/Abstract Full Text View citing articles Show Details

Dissociation Exponent (10) Dissociation Exponent (pK)

Dissociation Group

Temperature (Dissociation Exponent)

Solvent (Dissociation Exponent)

Method (Dissociation Exponent)

Type (Dissociation Exponent)

Comment (Dissociation Exponent)

10.1

a1/apparent

Huerta-Fontela, Maria; Galceran, Maria Teresa; Ventura, Francesc

Environmental Science and Technology, 2008 , vol. 42, # 18 p. 6809 - 6816 Title/Abstract Full Text View citing articles Show Details

-0.99

NH3(1+)

25 °C

H2O various solvent(s)

potentiometric

a1/thermodynamic

Athanasiou-Malaki; Koupparis; Hadjiioannou

(pk')pK(a)c: 9.90+-0.01 (H2O)

Reference

Analytical Chemistry, 1989 , vol. 61, # 13 p. 1358 - 1363 Title/Abstract Full Text View citing articles Show Details

Tencheva et al.

Arzneimittel Forschung, 1979 , vol. 29, p. 1331,1333


Full Text Show Details

(pk')logK(B)

Doyle; Proctor

Journal - Association of Official Analytical Chemists, 1972 , vol. 55, p. 328,329 Full Text Show Details

(pk')pK'(HA)

Modin; Johansson

Acta Pharmaceutica Suecica, 1971 , vol. 8, p. 561,565 Full Text Show Details

(k')

Chatten; Harris

Analytical Chemistry, 1962 , vol. 34, p. 1495,1499 Full Text Show Details

(pk')pK(b): 4.25

Zapior; Czapkiewicz

Roczniki Chemii, 1962 , vol. 36, p. 1863,1866,1867 Chem.Abstr., vol. 58, # 11986 Full Text Show Details

9.93

20 °C

H2O

potentiometric

a/apparent

Lewis

British Journal of Pharmacology and Chemotherapy, 1954 , vol. 9, p. 488,490 Full Text Show Details

4.23

25 °C

H2O

potentiometric

b/apparent

Leffler et al.

Journal of the American Chemical Society, 1951 , vol. 73, p. 2611 Full Text View citing articles Show Details

10.02

20 °C

H2O

potentiometric

a/apparent

Kieffer; Rumpf

Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1950 , vol. 230, p. 2302 Full Text Show Details

Electrical Moment (1) Description (Electrical Moment)

Reference

Dipole moment

Kumbar

Journal of Medicinal Chemistry, 1976 , vol. 19, p. 1232,1234 Full Text Show Details

Electrochemical Behaviour (4) Description (Electrochemical Behaviour)

Reference

Basicity

Nagy, Peter I.; Alagona, Giuliano; Ghio, Caterina; Takacs-Novak, Krisztina

Journal of the American Chemical Society, 2003 , vol. 125, # 9 p. 2770 - 2785 Title/Abstract Full Text View citing articles Show Details

Protonation

Nagy, Peter I.; Alagona, Giuliano; Ghio, Caterina; Takacs-Novak, Krisztina

Journal of the American Chemical Society, 2003 , vol. 125, # 9 p. 2770 - 2785 Title/Abstract Full Text View citing articles Show Details

Electrochemical properties

Luca et al.

Revista de Chimie (Bucharest, Romania), 1979 , vol. 30, p. 72 Full Text Show Details

Chatten; Harris

Analytical Chemistry, 1962 , vol. 34, p. 1495,1499 Full Text Show Details

Stability constant

Lachman

Journal of Pharmaceutical Sciences, 1965 , vol. 54, p. 1519,1523 Full Text Show Details

Electrochemical Characteristics (2) Description (Electrochemical Characteristics)

Product XRN (Electrochemical Characteristics)

Product

Comment (Electrochemical Characteristics)

Reference


polarographic halfwave potential

polarographic halfwave potential

5744022

Type: Irreversible half-wave potential. Product: /BRN= 5744022/. Method: cyclovoltammetry. Description: Pt-electrode, CH3CN/NaClO4; CH2Cl2/C4H9/NClO4

Hess; Ziebig

Pharmazie, 1981 , vol. 36, # 4 p. 253 - 256 Title/Abstract Full Text View citing articles Show Details

Hess et al.

Pharmazie, 1976 , vol. 31, p. 452,453 Full Text Show Details

Formyl(Nmethoxymethyl-αmethyl)phenylethylamin

Further Information (36) Description (Further Information)

Reference

Further information

Coutts; Jones; Liu

Biomedical Mass Spectrometry, 1978 , vol. 5, # 6 p. 418 - 422 Title/Abstract Full Text View citing articles Show Details

Further information

Rein et al.

Croatica Chemica Acta, 1977 , vol. 49, p. 251,253, 254, 256, 257 Full Text Show Details

Further information

Predmore; Christian

Analytical chemistry, 1976 , vol. 48, # 2 p. 361 - 363 Title/Abstract Full Text View citing articles Show Details

Further information

Cartoni et al.

Bollettino Chimico Farmaceutico, 1976 , vol. 115, p. 347,350 Full Text Show Details

Further information

Hess et al.

Pharmazie, 1976 , vol. 31, p. 452,453 Full Text Show Details

Further information

Kuhnert-Brandstaetter et al.

Pharmaceutica Acta Helvetiae, 1975 , vol. 50, p. 360,364 Full Text Show Details

Further information

De Silva; Strojny

Analytical Chemistry, 1975 , vol. 47, p. 714,716, 718 Full Text View citing articles Show Details

Further information

Hunneman

Chemiker-Zeitung, 1974 , vol. 98, p. 28,32 Full Text Show Details

Further information

Sung; Parker

Zeitschrift fuer Naturforschung, C: Journal of Biosciences, 1974 , vol. 29, p. 122,124 Full Text Show Details

Further information

Miles; Schenk

Analytical Chemistry, 1973 , vol. 45, p. 130,132 Full Text Show Details

Further information

Blang; Huang

Journal of Pharmaceutical Sciences, 1973 , vol. 62, p. 652 Full Text View citing articles Show Details

Further information

Telc et al.

Journal of Labelled Compounds, 1972 , vol. 8, p. 13,14, 19 Full Text Show Details

Further information

Serck-Hanssen

Archives of Mass Spectral Data, 1971 , vol. 2, p. 760 Full Text Show Details

Further information

Bergin; Carlstroem

Acta Crystallographica, Section B: Structural Crystallography and Crystal Chemistry, 1971 , vol. 27, p. 2146,2151 Full Text Show Details

Further information

Warren et al.

Journal - Association of Official Analytical Chemists, 1971 , vol. 54, p. 1179,1181,1186,1188 Full Text View citing articles Show Details

Further information

Fontani; Morandini

The Journal of pharmacy and pharmacology, 1970 , vol. 22, # 6 p. 411 - 413


Title/Abstract Full Text View citing articles Show Details

Further information

Reisch; Alfes; Moellmann

Die Pharmazie, 1968 , vol. 23, # 5 p. 245 - 246 Title/Abstract Full Text View citing articles Show Details

Further information

Furman

Journal - Association of Official Analytical Chemists, 1968 , vol. 51, p. 1111,1115 Full Text Show Details

Further information

Garrett, Chembarkar

Journal of Pharmaceutical Sciences, 1968 , vol. 57, p. 1401,1402 Full Text Show Details

Further information

Cholodov et al.

Zhurnal Organicheskoi Khimii, 1967 , vol. 3, p. 1513,1470 Full Text Show Details

Hide facts Description (Further Information)

Reference

Further information

Griffin; Banker

Journal of Pharmaceutical Sciences, 1967 , vol. 56, p. 1098,1099 Full Text Show Details

Further information

Beckett et al.

Journal of Pharmacy and Pharmacology, 1967 , vol. 19, p. 273,291 Full Text Show Details

Further information

Kracmar; Kracmarova

Cesko-Slovenska Farmacie, 1966 , vol. 15, p. 16,18 Full Text Show Details

Further information

Hayden et al.

Journal - Association of Official Analytical Chemists, 1966 , vol. 49, p. 1109,1119 Full Text Show Details

Further information

Sciortino

Bollettino Chimico Farmaceutico, 1966 , vol. 105, p. 223,224 Full Text Show Details

Further information

Sinsheimer; Keuhnellan

Journal of Pharmaceutical Sciences, 1966 , vol. 55, p. 1240,1241 Full Text Show Details

Further information

Thompson,W.E. et al.

Journal of Pharmaceutical Sciences, 1965 , vol. 54, p. 1819 - 1821 Full Text View citing articles Show Details

Further information

Duvall; Koshy; Pyles

Journal of pharmaceutical sciences, 1965 , vol. 54, # 4 p. 607 - 611 Title/Abstract Full Text View citing articles Show Details

Further information

Brannon; Hayden

Journal of the Association of Official Agricultural Chemists, 1964 , vol. 47, p. 918,927 Full Text Show Details

Further information

Seiler; Wiechmann

Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1964 , vol. 337, p. 229,231, 238 Full Text Show Details

Further information

ELSLAGER; WEINSTEIN; WORTH

Journal of medicinal chemistry, 1964 , vol. 7, p. 493 - 500 Title/Abstract Full Text View citing articles Show Details

Further information

Nace; King

Journal of Medicinal and Pharmaceutical Chemistry, 1962 , vol. 5, p. 1316,1321 Full Text Show Details

Further information

Kum-Tatt

Journal of Pharmacy and Pharmacology, 1960 , vol. 12, p. 666 Full Text Show Details

Further information

Brandstaetter-Kuhnert et al.

Scientia Pharmaceutica, 1960 , vol. 28, # 1 p. 7,8-15


Chem.Abstr., 1960 , # 17802 Full Text Show Details

Further information

Soc. Chim. Org. Biol.

Patent: FRM79 , 1960 ; Chem.Abstr., 1963 , vol. 58, # 10302g Full Text Show Details

Further information

Thomis; Kotionis

Analytica Chimica Acta, 1956 , vol. 14, p. 457 Chem.Abstr., 1957 , # 5624 Full Text View citing articles Show Details

Ionization Potential (1) Ionization Potential

Method (Ionization Potential)

Reference

10.17 eV

spectrographical

Meincke; Kottke; Beyrich

Pharmazie, 1992 , vol. 47, # 10 p. 780 - 783 Title/Abstract Full Text View citing articles Show Details

Liquid/Liquid Systems (MCS) (1) Description (Liquid/Liquid Systems (MCS))

Reference

Distribution between solvent 1 + 2

Beckett; Moffat

The Journal of pharmacy and pharmacology, 1969 , vol. 21, p. Suppl:144S+ Title/Abstract Full Text View citing articles Show Details

Mihailova; Testa

European Journal of Medicinal Chemistry, 1978 , vol. 13, # 1 p. 49 - 52 Title/Abstract Full Text View citing articles Show Details

Thies; Ermer

Naturwissenschaften, 1962 , vol. 49, p. 37 Full Text View citing articles Show Details

Donike; Iffland; Jaenicke

Arzneimittel-Forschung, 1974 , vol. 24, # 4 p. 556 - 560 Title/Abstract Full Text View citing articles Show Details

Mechanical & Physical Properties (MCS) (1) Description (Mechanical & Physical Properties (MCS))

Partner (Mechanical & Physical Properties (MCS))

Temperature (Mechanical & Physical Properties (MCS))

Partial molal volume

water

25 °C

Reference Shahidi, Fereidoon

Canadian Journal of Chemistry, 1987 , vol. 65, p. 1924 - 1926 Title/Abstract Full Text Show Details

Mechanical Properties (1) Description (Mechanical Properties)

Reference

Viscosity

Bloor; Morrinson

Journal of Pharmacy and Pharmacology, 1972 , vol. 24, p. 927,928,931,932 Full Text View citing articles Show Details

Optical Rotatory Dispersion (1) Reference Potapow; Terent'ew

J. Gen. Chem. USSR (Engl. Transl.), 1961 , vol. 31, p. 1003,927 Chem.Abstr., 1961 , # 23389 Full Text Show Details

Optical Rotatory Power (1) Type (Optical Rotatory Power)

Concentration (Optical Rotatory Power)

Solvent (Optical Rotatory Power)

Optical Rotatory Power

Wavelength (Optical Rotatory Power)

Temperature (Optical Rotatory Power)

[alpha]

10.62

ethanol

34.5 deg

589 nm

15 °C

Reference Yamada et al.

Tetrahedron Letters, 1976 , p. 1001


Full Text View citing articles Show Details

Partition octan-1-ol/water (MCS) (3) log POW

pH

Location

-0.63

7.4

supporting information

aq.buffer

Gunaydin, Hakan

ACS Medicinal Chemistry Letters, 2016 , vol. 7, # 1 p. 89 - 93 Title/Abstract Full Text View citing articles Show Details

1.76

supporting information

Gmez-Ros, Germn Augusto; Pawliszyn, Janusz

Angewandte Chemie - International Edition, 2014 , vol. 53, # 52 p. 14503 14507 Angew. Chem., 2014 , vol. 126, # 52 p. 14731 - 14735,5 Title/Abstract Full Text View citing articles Show Details

1.76

Huerta-Fontela, Maria; Galceran, Maria Teresa; Ventura, Francesc

Environmental Science and Technology, 2008 , vol. 42, # 18 p. 6809 - 6816 Title/Abstract Full Text View citing articles Show Details

Comment (Partition octan-1-ol/water (MCS))

Reference

Self-diffusion (1) Reference Bloor; Morrinson

Journal of Pharmacy and Pharmacology, 1972 , vol. 24, p. 927,928,931,932 Full Text View citing articles Show Details

Solubility (MCS) (1) Solubility

Saturation

Temperature (Solubility (MCS))

Solvent (Solubility (MCS))

0.0676045 g·l-1

in solution

25 °C

phosphate buffer

Reference

Alelyunas, Yun W.; Empfield, James R.; McCarthy, Dennis; Spreen, Russell C.; Bui, Khanh; Pelosi-Kilby, Luciana; Shen, Cindy

Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 24 p. 7312 - 7316 Title/Abstract Full Text View citing articles Show Details

Vapour Pressure (1) Vapour Pressure

Temperature (Vapour Pressure)

Reference

0.26 Torr

26 °C

Steldt; Chen

Journal of the American Pharmaceutical Association (1912-1977), 1954 , vol. 43, p. 477,478 Full Text Show Details

Spectra NMR Spectroscopy (36) Description (NMR Spectroscopy)

Nucleus (NMR Spectroscopy)

Coupling Nuclei

Solvents (NMR Spectroscopy)

Frequency (NMR Spectroscopy)

Original Text (NMR Spectroscopy)

Chemical shifts Spectrum

1H

chloroform-d1

300 MHz

Chemical shifts Spectrum

13C

chloroform-d1

Chemical shifts

1H

chloroform-d1

Location

Reference

supporting information

Martínez-Montero, Lía; Díaz-Rodríguez, Alba; Gotor, Vicente; Gotor-Fernández, Vicente; Lavandera, Iván

Green Chemistry, 2015 , vol. 17, # 5 p. 2794 2798 Title/Abstract Full Text View citing articles Show Details

75 MHz

supporting information

Martínez-Montero, Lía; Díaz-Rodríguez, Alba; Gotor, Vicente; Gotor-Fernández, Vicente; Lavandera, Iván

Green Chemistry, 2015 , vol. 17, # 5 p. 2794 2798 Title/Abstract Full Text View citing articles Show Details

500 MHz

*H NMR (500 MHz, CDC13) δ

Page/Page column 66

ESS, Daniel, Halsell; FALCK, John, Russell; JAT, Jawahar, Lal; URTI, Laszlo


Chemical shifts

13C

chloroform-d1

126 MHz

8.46 (br s, 2H), 7.34-7.20 (m, 5H), 3.65-3.53 (m, 1H), 3.27 (dd, J= 13.4, 5.1 Hz, 1H), 2.87 (dd, J= 13.3, 9.1 Hz, 1H), 1.39 (d, J= 6.4 Hz, 3H);

13C

NMR (126 MHz, CDC13) δ 135.83, 129.35, 128.87, 127.26, 49.80, 41.07, 18.13.

Page/Page column 66

Patent: WO2015/103505 A2, 2015 ; Title/Abstract Full Text Show Details

ESS, Daniel, Halsell; FALCK, John, Russell; JAT, Jawahar, Lal; URTI, Laszlo

Patent: WO2015/103505 A2, 2015 ; Title/Abstract Full Text Show Details

Chemical shifts Spectrum

1H

chloroform-d1

400 MHz

supporting information

Poulhes, Florent; Vanthuyne, Nicolas; Bertrand, Michele P.; Gastaldi, Stephane; Gil, Gerard

Journal of Organic Chemistry, 2011 , vol. 76, # 17 p. 7281 - 7286 Title/Abstract Full Text View citing articles Show Details

Chemical shifts Spectrum

13C

chloroform-d1

75 MHz

supporting information

Poulhes, Florent; Vanthuyne, Nicolas; Bertrand, Michele P.; Gastaldi, Stephane; Gil, Gerard

Journal of Organic Chemistry, 2011 , vol. 76, # 17 p. 7281 - 7286 Title/Abstract Full Text View citing articles Show Details

DEPT (Distorsionless Enhancement by Polarisation Transfer) Chemical shifts Spectrum

13C

chloroform-d1

75 MHz

supporting information

Poulhes, Florent; Vanthuyne, Nicolas; Bertrand, Michele P.; Gastaldi, Stephane; Gil, Gerard

Journal of Organic Chemistry, 2011 , vol. 76, # 17 p. 7281 - 7286 Title/Abstract Full Text View citing articles Show Details

Chemical shifts

1H

chloroform-d1

400 MHz

supporting information

Imm, Sebastian; Neubert, Lorenz; Neumann, Helfried; Beller, Matthias

Angewandte Chemie - International Edition, 2010 , vol. 49, # 44 p. 8126 - 8129 Title/Abstract Full Text View citing articles Show Details

Munoz, Lourdes; Rodriguez, Anna M.; Rosell, Gloria; Bosch, M. Pilar; Guerrero, Angel

Organic and Biomolecular Chemistry, 2011 , vol. 9, # 23 p. 8171 - 8177 Title/Abstract Full Text View citing articles Show Details

Chemical shifts

13C

chloroform-d1

100 MHz

supporting information

Imm, Sebastian; Neubert, Lorenz; Neumann, Helfried; Beller, Matthias

Angewandte Chemie - International Edition, 2010 , vol. 49, # 44 p. 8126 - 8129 Title/Abstract Full Text View citing articles Show Details

Munoz, Lourdes; Rodriguez, Anna M.; Rosell, Gloria; Bosch, M. Pilar; Guerrero, Angel

Organic and Biomolecular Chemistry, 2011 , vol. 9, # 23 p. 8171 - 8177 Title/Abstract Full Text View citing articles Show Details

Chemical shifts

1H

chloroform-d1

300 MHz

Schulze, Matthias

Synthetic Communications, 2010 , vol. 40, # 10 p. 1461 - 1476 Title/Abstract Full Text View citing articles Show Details

Chemical shifts

13C

chloroform-d1

75 MHz

Schulze, Matthias

Synthetic Communications, 2010 , vol. 40, # 10 p. 1461 - 1476 Title/Abstract Full Text View citing articles Show Details

Chemical shifts

1H

dimethylsulfoxide-

300 MHz

Vahermo, Mikko; Suominen, Tina; Leinonen,


Chemical shifts

13C

Chemical shifts

Antti; Yli-Kauhaluoma, Jari

Archiv der Pharmazie, 2009 , vol. 342, # 4 p. 201 - 209 Title/Abstract Full Text View citing articles Show Details

d6

dimethylsulfoxided6

75 MHz

Vahermo, Mikko; Suominen, Tina; Leinonen, Antti; Yli-Kauhaluoma, Jari

Archiv der Pharmazie, 2009 , vol. 342, # 4 p. 201 - 209 Title/Abstract Full Text View citing articles Show Details

1H

300 MHz

Routaboul, Lucie; Vanthuyne, Nicolas; Gastaldi, Stephane; Gil, Gerard; Bertrand, Michele

Journal of Organic Chemistry, 2008 , vol. 73, # 2 p. 364 - 368 Title/Abstract Full Text View citing articles Show Details

Spectrum

13C

CDCl3

75 MHz

Nechab, Malek; Azzi, Nadia; Vanthuyne, Nicolas; Bertrand, Michele; Gastaldi, Stephane; Gil, Gerard

Journal of Organic Chemistry, 2007 , vol. 72, # 18 p. 6918 - 6923 Title/Abstract Full Text View citing articles Show Details

Routaboul, Lucie; Vanthuyne, Nicolas; Gastaldi, Stephane; Gil, Gerard; Bertrand, Michele

Journal of Organic Chemistry, 2008 , vol. 73, # 2 p. 364 - 368 Title/Abstract Full Text View citing articles Show Details

Chemical shifts

13C

CDCl3

75 MHz

Gyenes, Ferenc; Bergmann, Kathryn E.; Welch, John T.

Journal of Organic Chemistry, 1998 , vol. 63, # 9 p. 2824 - 2828 Title/Abstract Full Text View citing articles Show Details

Routaboul, Lucie; Vanthuyne, Nicolas; Gastaldi, Stephane; Gil, Gerard; Bertrand, Michele

Journal of Organic Chemistry, 2008 , vol. 73, # 2 p. 364 - 368 Title/Abstract Full Text View citing articles Show Details

Spectrum

1H

CDCl3

300 MHz

Nechab, Malek; Azzi, Nadia; Vanthuyne, Nicolas; Bertrand, Michele; Gastaldi, Stephane; Gil, Gerard

Journal of Organic Chemistry, 2007 , vol. 72, # 18 p. 6918 - 6923 Title/Abstract Full Text View citing articles Show Details

Chemical shifts

1H

CDCl3

400 MHz

Haak, Edgar; Siebeneicher, Holger; Doye, Sven

Organic Letters, 2000 , vol. 2, # 13 p. 1935 1937 Title/Abstract Full Text View citing articles Show Details

Viswanathan, Rajesh; Prabhakaran, Erode N.; Plotkin, Michael A.; Johnston, Jeffrey N.

Journal of the American Chemical Society, 2003 , vol. 125, # 1 p. 163 - 168 Title/Abstract Full Text View citing articles Show Details

Guisado, Cristina; Waterhouse, Jodie E.; Price, Wayne S.; Jorgensen, Michael R.; Miller, Andrew D.

Organic and Biomolecular Chemistry, 2005 , vol. 3, # 6 p. 1049 - 1057 Title/Abstract Full Text View citing articles Show Details

1H

1H

CDCl3

400 MHz

Haak, Edgar; Siebeneicher, Holger; Doye, Sven

Organic Letters, 2000 , vol. 2, # 13 p. 1935 1937


Title/Abstract Full Text View citing articles Show Details

Viswanathan, Rajesh; Prabhakaran, Erode N.; Plotkin, Michael A.; Johnston, Jeffrey N.

Journal of the American Chemical Society, 2003 , vol. 125, # 1 p. 163 - 168 Title/Abstract Full Text View citing articles Show Details

Guisado, Cristina; Waterhouse, Jodie E.; Price, Wayne S.; Jorgensen, Michael R.; Miller, Andrew D.

Organic and Biomolecular Chemistry, 2005 , vol. 3, # 6 p. 1049 - 1057 Title/Abstract Full Text View citing articles Show Details

Chemical shifts

13C

Description (NMR Spectroscopy)

Nucleus (NMR Spectroscopy)

Coupling Nuclei

Chemical shifts

1H

CDCl3

100 MHz

Haak, Edgar; Siebeneicher, Holger; Doye, Sven

Organic Letters, 2000 , vol. 2, # 13 p. 1935 1937 Title/Abstract Full Text View citing articles Show Details

Viswanathan, Rajesh; Prabhakaran, Erode N.; Plotkin, Michael A.; Johnston, Jeffrey N.

Journal of the American Chemical Society, 2003 , vol. 125, # 1 p. 163 - 168 Title/Abstract Full Text View citing articles Show Details

Guisado, Cristina; Waterhouse, Jodie E.; Price, Wayne S.; Jorgensen, Michael R.; Miller, Andrew D.

Organic and Biomolecular Chemistry, 2005 , vol. 3, # 6 p. 1049 - 1057 Title/Abstract Full Text View citing articles Show Details

Hide facts Solvents (NMR Spectroscopy)

Temperature (NMR Spectroscopy)

Frequency (NMR Spectroscopy)

Comment (NMR Spectroscopy)

CDCl3

500 MHz

Li, Yanjun; Izumi, Taeko

Journal of the Chinese Chemical Society (Taipei, Taiwan), 2002 , vol. 49, # 4 p. 505 - 508 Title/Abstract Full Text View citing articles Show Details

Li, Yanjun; Izumi, Taeko

Journal of Chemical Research - Part S, 2003 , # 3 p. 128 - 129 Title/Abstract Full Text View citing articles Show Details

1H

1H

CDCl3

500 MHz

Li, Yanjun; Izumi, Taeko

Journal of the Chinese Chemical Society (Taipei, Taiwan), 2002 , vol. 49, # 4 p. 505 - 508 Title/Abstract Full Text View citing articles Show Details

Li, Yanjun; Izumi, Taeko

Journal of Chemical Research - Part S, 2003 , # 3 p. 128 - 129 Title/Abstract Full Text View citing articles Show Details

Chemical shifts

1H

D2O

26 °C

Thunhorst, Martin; Holzgrabe, Ulrike

Magnetic Resonance in Chemistry, 1998 , vol. 36, # 3 p. 211 - 216 Title/Abstract Full Text View citing articles Show Details

Chemical shifts

1H

CDCl3

300 MHz

Gyenes, Ferenc; Bergmann, Kathryn E.; Welch, John T.

Journal of Organic Chemistry, 1998 , vol. 63, # 9 p. 2824 - 2828 Title/Abstract Full Text View citing articles Show Details

1H

1H

CDCl3

300 MHz

Gyenes, Ferenc; Bergmann, Kathryn E.; Welch, John T.

Journal of Organic Chemistry, 1998 , vol. 63, # 9 p. 2824 - 2828 Title/Abstract Full Text View citing articles Show Details

Reference


Chemical shifts

13C

CDCl3

25 °C

Border, Corinne L.; Craik, David J.; Shehan, B. Philip

Magnetic Resonance in Chemistry, 1993 , vol. 31, # 3 p. 222 - 230 Title/Abstract Full Text Show Details

Spin-lattice relaxation time (T1)

Border, Corinne L.; Craik, David J.; Shehan, B. Philip

Magnetic Resonance in Chemistry, 1993 , vol. 31, # 3 p. 222 - 230 Title/Abstract Full Text Show Details

Chemical shifts

1H

Meincke; Kottke; Beyrich

Pharmazie, 1992 , vol. 47, # 9 p. 697 - 699 Title/Abstract Full Text View citing articles Show Details

Bell, Harold M.; Bowles, Deborah B.; Senese, Fred

Organic Magnetic Resonance, 1981 , vol. 16, # 4 p. 285 - 289 Title/Abstract Full Text Show Details

Chemical shifts

13C

CDCl3

Gee, Antony; Langstroem, Bengt

Acta Chemica Scandinavica, 1991 , vol. 45, # 4 p. 431 - 435 Title/Abstract Full Text Show Details

Chemical shifts

1H

CDCl3

Toda, Fumio; Mori, Koji; Okada, Jyoji; Node, Manabu; Itoh, Akichika; et al.

Chemistry Letters, 1988 , p. 131 - 134 Title/Abstract Full Text Show Details

Chemical shifts

1H

CCl4

El-Torki, Farid M.; Jacobus John

Journal of Organic Chemistry, 1985 , vol. 50, # 8 p. 1314 - 1316 Title/Abstract Full Text View citing articles Show Details

Spin-spin coupling constants

CCl4

1H-1H

El-Torki, Farid M.; Jacobus John

Journal of Organic Chemistry, 1985 , vol. 50, # 8 p. 1314 - 1316 Title/Abstract Full Text View citing articles Show Details

Spectrum

1H

CDCl3

24 °C

Ali, Abdel Rahman el Nasser Ossman

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 8 p. 762 - 765 Title/Abstract Full Text Show Details

NMR with shift reagents

Ali, Abdel Rahman el Nasser Ossman

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 8 p. 762 - 765 Title/Abstract Full Text Show Details

NMR

Landor et al.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1974 , p. 1294,1299 Full Text Show Details

Krieg

Arzneimittel-Forschung, 1974 , vol. 24, # 2 p. 133 - 134 Title/Abstract Full Text View citing articles Show Details

Smith et al.

Journal of Pharmaceutical Sciences, 1976 , vol. 65, p. 412,413, 414 Full Text View citing articles Show Details

Lambert et al.

Organic Magnetic Resonance, 1975 , vol. 7, p. 266,272 Full Text Show Details

Neville et al.

Journal of Medicinal Chemistry, 1971 , vol. 14, p. 717,718 Full Text Show Details

Lambert et al.


Spectroscopy Letters, 1975 , vol. 8, p. 509,511 Full Text Show Details

Spectrum

Fig. 1

Neville et al.

Journal of Medicinal Chemistry, 1971 , vol. 14, p. 717,718 Full Text Show Details

IR Spectroscopy (5) Description (IR Spectroscopy)

Solvent (IR Spectroscopy)

Bands

supporting information

film

Munoz, Lourdes; Rodriguez, Anna M.; Rosell, Gloria; Bosch, M. Pilar; Guerrero, Angel

Organic and Biomolecular Chemistry, 2011 , vol. 9, # 23 p. 8171 - 8177 Title/Abstract Full Text View citing articles Show Details

Bands

potassium bromide

Vahermo, Mikko; Suominen, Tina; Leinonen, Antti; Yli-Kauhaluoma, Jari

Archiv der Pharmazie, 2009 , vol. 342, # 4 p. 201 - 209 Title/Abstract Full Text View citing articles Show Details

Bands

film

Viswanathan, Rajesh; Prabhakaran, Erode N.; Plotkin, Michael A.; Johnston, Jeffrey N.

Journal of the American Chemical Society, 2003 , vol. 125, # 1 p. 163 168 Title/Abstract Full Text View citing articles Show Details

Bands

neat (no solvent)

Gyenes, Ferenc; Bergmann, Kathryn E.; Welch, John T.

Journal of Organic Chemistry, 1998 , vol. 63, # 9 p. 2824 - 2828 Title/Abstract Full Text View citing articles Show Details

Haak, Edgar; Siebeneicher, Holger; Doye, Sven

Organic Letters, 2000 , vol. 2, # 13 p. 1935 - 1937 Title/Abstract Full Text View citing articles Show Details

IR

Blang; Huang

Journal of Pharmaceutical Sciences, 1972 , vol. 61, p. 1770,1772, 1774 Full Text View citing articles Show Details

Location

Comment (IR Spectroscopy)

Reference

Mass Spectrometry (28) Description (Mass Spectrometry)

Location

Reference

tandem mass spectrometry CID (collision-induced dissociation) spectrum

Damon, Deidre E.; Davis, Kathryn M.; Moreira, Camila R.; Capone, Patricia; Cruttenden, Riley; BaduTawiah, Abraham K.

Analytical Chemistry, 2016 , vol. 88, # 3 p. 1878 - 1884 Title/Abstract Full Text View citing articles Show Details

high resolution mass spectrometry (HRMS) spectrum

Duvivier, Wilco F.; Van Putten, Marc R.; Van Beek, Teris A.; Nielen, Michel W. F.

Analytical Chemistry, 2016 , vol. 88, # 4 p. 2489 - 2496 Title/Abstract Full Text View citing articles Show Details

APCI (atmospheric pressure chemical ionization) tandem mass spectrometry spectrum

Crevelin, Eduardo J.; Salami, Fernanda H.; Alves, Marcela N. R.; De Martinis, Bruno S.; Crotti, Antônio E. M.; Moraes, Luiz A. B.

Journal of the American Society for Mass Spectrometry, 2016 , vol. 27, # 5 p. 944 - 947 Title/Abstract Full Text View citing articles Show Details

electrospray ionisation (ESI) spectrum

Badu-Tawiah, Abraham; Cooks, R. Graham

Journal of the American Society for Mass Spectrometry, 2010 , vol. 21, # 8 p. 1423 - 1431 Title/Abstract Full Text View citing articles Show Details

Jeong, Eun Sook; Kim, So-Hee; Cha, Eun-Ju; Lee, Kang Mi; Kim, Ho Jun; Lee, Sang-Won; Kwon, OhSeung; Lee, Jaeick

Rapid Communications in Mass Spectrometry, 2015 , vol. 29, # 4 p. 367 - 384 Title/Abstract Full Text View citing articles Show Details

liquid chromatography mass spectrometry (LCMS) electrospray ionisation (ESI) spectrum

Jeong, Eun Sook; Kim, So-Hee; Cha, Eun-Ju; Lee, Kang Mi; Kim, Ho Jun; Lee, Sang-Won; Kwon, OhSeung; Lee, Jaeick

Rapid Communications in Mass Spectrometry, 2015 , vol. 29, # 4 p. 367 - 384 Title/Abstract Full Text Show Details

APCI (atmospheric pressure chemical ionization) spectrum

supporting information

Martínez-Montero, Lía; Díaz-Rodríguez, Alba; Gotor, Vicente; Gotor-Fernández, Vicente; Lavandera, Iván

Green Chemistry, 2015 , vol. 17, # 5 p. 2794 - 2798 Title/Abstract Full Text View citing articles Show Details


spectrum

Haak, Edgar; Siebeneicher, Holger; Doye, Sven

Organic Letters, 2000 , vol. 2, # 13 p. 1935 - 1937 Title/Abstract Full Text View citing articles Show Details

Espy, Ryan D.; Teunissen, Sebastiaan Frans; Manicke, Nicholas E.; Ren, Yue; Ouyang, Zheng; Van Asten, Arian; Cooks, R. Graham

Analytical Chemistry, 2014 , vol. 86, # 15 p. 7712 - 7718 Title/Abstract Full Text View citing articles Show Details

liquid chromatography mass spectrometry (LCMS) CID (collision-induced dissociation) spectrum

Lin, Huei-Ru; Liao, Chao-Chuan; Lin, Tzu-Chieh

Rapid Communications in Mass Spectrometry, 2014 , vol. 28, # 19 p. 2043 - 2053 Title/Abstract Full Text View citing articles Show Details

high resolution mass spectrometry (HRMS) liquid chromatography mass spectrometry (LCMS) time-of-flight mass spectra (TOFMS) tandem mass spectrometry spectrum

Roemmelt, Andreas T.; Steuer, Andrea E.; Poetzsch, Michael; Kraemer, Thomas

Analytical Chemistry, 2014 , vol. 86, # 23 p. 11742 - 11749 Title/Abstract Full Text View citing articles Show Details

liquid chromatography mass spectrometry (LCMS) electrospray ionisation (ESI) tandem mass spectrometry spectrum

Spinner; Klima; Kempf; Huppertz; Auwärter; Altenburger; Neukamm

Journal of Mass Spectrometry, 2014 , vol. 49, # 12 p. 1306 - 1313 Title/Abstract Full Text View citing articles Show Details

tandem mass spectrometry spectrum

supporting information

Gmez-Ros, Germn Augusto; Pawliszyn, Janusz

Angewandte Chemie - International Edition, 2014 , vol. 53, # 52 p. 14503 - 14507 Angew. Chem., 2014 , vol. 126, # 52 p. 14731 - 14735,5 Title/Abstract Full Text View citing articles Show Details

tandem mass spectrometry electrospray ionisation (ESI) high resolution mass spectrometry (HRMS) spectrum

Fedorova, Ganna; Randak, Tomas; Lindberg, Richard H.; Grabic, Roman

Rapid Communications in Mass Spectrometry, 2013 , vol. 27, # 15 p. 1751 - 1762 Title/Abstract Full Text View citing articles Show Details

electrospray ionisation (ESI) high resolution mass spectrometry (HRMS) spectrum

Fedorova, Ganna; Randak, Tomas; Lindberg, Richard H.; Grabic, Roman

Rapid Communications in Mass Spectrometry, 2013 , vol. 27, # 15 p. 1751 - 1762 Title/Abstract Full Text View citing articles Show Details

Tandem mass spectrometry TOFMS (Time of flight mass spectrum) ESI (Electrospray ionisation) Spectrum

Bijlsma, Lubertus; Sancho, Juan V.; Hernandez, Felix; Niessen, Wilfried M.A.

Journal of Mass Spectrometry, 2011 , vol. 46, # 9 p. 865 - 875 Title/Abstract Full Text View citing articles Show Details

EI (Electron impact) Spectrum

supporting information

Munoz, Lourdes; Rodriguez, Anna M.; Rosell, Gloria; Bosch, M. Pilar; Guerrero, Angel

Organic and Biomolecular Chemistry, 2011 , vol. 9, # 23 p. 8171 - 8177 Title/Abstract Full Text View citing articles Show Details

ESI (Electrospray ionisation) Tandem mass spectrometry Spectrum

Liu, Ying; Uboh, Cornelius E.; Soma, Lawrence R.; Li, Xiaoqing; Guan, Fuyu; You, Youwen; Chen, JinWen

Analytical Chemistry, 2011 , vol. 83, # 17 p. 6834 - 6841 Title/Abstract Full Text View citing articles Show Details

EI (Electron impact) GCMS (Gas chromatography mass spectrometry) Spectrum

supporting information

Imm, Sebastian; Neubert, Lorenz; Neumann, Helfried; Beller, Matthias

Angewandte Chemie - International Edition, 2010 , vol. 49, # 44 p. 8126 - 8129 Title/Abstract Full Text View citing articles Show Details

HRMS (High resolution mass spectrometry) ESI (Electrospray ionisation) LCMS (Liquid chromatography mass spectrometry) TOFMS (Time of flight mass spectrum) Spectrum

supporting information

Imm, Sebastian; Neubert, Lorenz; Neumann, Helfried; Beller, Matthias

Angewandte Chemie - International Edition, 2010 , vol. 49, # 44 p. 8126 - 8129 Title/Abstract Full Text View citing articles Show Details

HRMS (High resolution mass spectrometry) TOFMS (Time of flight mass spectrum) ESI (Electrospray ionisation) LCMS (Liquid chromatography mass spectrometry)

Vonaparti; Lyris; Angelis; Panderi; Koupparis; Tsantili-Kakoulidou; Peters; Nielen; Georgakopoulos

Rapid Communications in Mass Spectrometry, 2010 , vol. 24, # 11 p. 1595 - 1609 Title/Abstract Full Text View citing articles Show Details


Spectrum LCMS (Liquid chromatography mass spectrometry) IT (ion trap) Tandem mass spectrometry Spectrum

Lee, Sang Kyu; Kim, So-Hee; Kim, Ho Jun; Yoo, Hye Hyun; Kwon, Oh Seung; In, Moon Kyo; Jin, Changbae; Kim, Dong Hyun; Lee, Jaeick

Rapid Communications in Mass Spectrometry, 2010 , vol. 24, # 21 p. 3139 - 3145 Title/Abstract Full Text View citing articles Show Details

Hide facts Description (Mass Spectrometry)

Comment (Mass Spectrometry)

APCI (atmospheric pressure chemical ionization) Spectrum

Inoue, Hiroyuki; Hashimoto, Hiroaki; Watanabe, Susumu; Iwata, Yuko T.; Kanamori, Tatsuyuki; Miyaguchi, Hajime; Tsujikawa, Kenji; Kuwayama, Kenji; Tachi, Noriyuki; Uetake, Naohito

Journal of Mass Spectrometry, 2009 , vol. 44, # 9 p. 1300 - 1307 Title/Abstract Full Text View citing articles Show Details

APCI (atmospheric pressure chemical ionization) Tandem mass spectrometry Spectrum

Inoue, Hiroyuki; Hashimoto, Hiroaki; Watanabe, Susumu; Iwata, Yuko T.; Kanamori, Tatsuyuki; Miyaguchi, Hajime; Tsujikawa, Kenji; Kuwayama, Kenji; Tachi, Noriyuki; Uetake, Naohito

Journal of Mass Spectrometry, 2009 , vol. 44, # 9 p. 1300 - 1307 Title/Abstract Full Text View citing articles Show Details

LCMS (Liquid chromatography mass spectrometry) ESI (Electrospray ionisation) Tandem mass spectrometry Spectrum

mol peak

Thoerngren, John-Olof; Oestervall, Fredrik; Garle, Mats

Journal of Mass Spectrometry, 2008 , vol. 43, # 7 p. 980 - 992 Title/Abstract Full Text View citing articles Show Details

spectrum tandem mass spectrometry

Pihlainen, Katja; Grigoras, Kestutis; Franssila, Sami; Ketola, Raimo; Kotiaho, Tapio; Kostiainen, Risto

Journal of Mass Spectrometry, 2005 , vol. 40, # 4 p. 539 - 545 Title/Abstract Full Text View citing articles Show Details

positive secondary ions

Zappey, Herman; Fokkens, Roel H.; Ingemann, Steen; Nibbering, Nico M. M.; Florencio, Helena

Organic Mass Spectrometry, 1991 , vol. 26, # 6 p. 587 - 594 Title/Abstract Full Text Show Details

fragmentation pattern spectrum electron impact (EI)

Zappey, Herman; Fokkens, Roel H.; Ingemann, Steen; Nibbering, Nico M. M.; Florencio, Helena

Organic Mass Spectrometry, 1991 , vol. 26, # 6 p. 587 - 594 Title/Abstract Full Text Show Details

chemical ionization (CI) spectrum

collisional activation

Todd; Stafford Jr.; Kelley; Syka; Cooks; Louris

Analytical Chemistry, 1987 , vol. 59, # 13 p. 1677 - 1685 Title/Abstract Full Text View citing articles Show Details

Coutts; Jones; Liu

Biomedical Mass Spectrometry, 1978 , vol. 5, # 6 p. 418 - 422 Title/Abstract Full Text View citing articles Show Details

Milne et al.

Analytical Chemistry, 1971 , vol. 43, p. 1815,1817 Full Text Show Details

Reisch et al.

Journal of Pharmacy and Pharmacology, 1968 , vol. 20, p. 81,85 Full Text Show Details

Hunneman

Chemiker-Zeitung, 1974 , vol. 98, p. 28,32 Full Text Show Details

Brandenberger

Pharmaceutica Acta Helvetiae, 1970 , vol. 45, p. 394,406 Full Text Show Details

Arsenault et al.

Analytical Chemistry, 1971 , vol. 43, p. 1720 Full Text View citing articles Show Details

Serck-Hanssen

Archives of Mass Spectral Data, 1971 , vol. 2, p. 760 Full Text Show Details

Cartoni et al.

Bollettino Chimico Farmaceutico, 1976 , vol. 115, p. 347,350 Full Text Show Details

Kamei et al.

Chemical and Pharmaceutical Bulletin, 1973 , vol. 21, p. 1996,2000 Full Text Show Details

Beckett et al.

Journal of Pharmacy and Pharmacology, 1967 , vol. 19, p. 273,291 Full Text Show Details

UV/VIS Spectroscopy (8)

Reference


Description (UV/VIS Spectroscopy)

Solvent (UV/VIS Spectroscopy)

Comment (UV/VIS Spectroscopy)

Spectrum

Predmore; Christian

Analytical chemistry, 1976 , vol. 48, # 2 p. 361 - 363 Title/Abstract Full Text View citing articles Show Details

Furman

Journal - Association of Official Analytical Chemists, 1968 , vol. 51, p. 1111,1115 Full Text Show Details

Ruckpaul et al.

Croatica Chemica Acta, 1977 , vol. 49, p. 339,343 Full Text Show Details

Blasco-Gomez; Bosch-Reig; Campins-Falco; Molins-Legua; Herraez-Hernandez

Analytical Chemistry, 2000 , vol. 72, # 11 p. 2559 - 2565 Title/Abstract Full Text View citing articles Show Details

UV/VIS

Blang; Huang

Journal of Pharmaceutical Sciences, 1972 , vol. 61, p. 1770,1772, 1774 Full Text View citing articles Show Details

Bloor; Morrinson

Journal of Pharmacy and Pharmacology, 1972 , vol. 24, p. 927,928,931,932 Full Text View citing articles Show Details

Spectrum

CHCl3

240 - 280 nm

Rontondaro

Journal of the Association of Official Agricultural Chemists, 1957 , vol. 40, p. 824,827 Full Text Show Details

Spectrum

aq. H2SO4

230 - 280 nm

Rontondaro

Journal of the Association of Official Agricultural Chemists, 1957 , vol. 40, p. 824,827 Full Text Show Details

Spectrum

ethanol

240 - 300 nm

FREEMAN

Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1953 , vol. 42, # 10 p. 621 - 622 Title/Abstract Full Text View citing articles Show Details

Spectrum

ethanol

245 - 270 nm

EBSTEIN; VAN METER

Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1952 , vol. 41, # 7 p. 372 - 374 Title/Abstract Full Text View citing articles Show Details

Spectrum

diethyl ether

245 - 270 nm

EBSTEIN; VAN METER

Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1952 , vol. 41, # 7 p. 372 - 374 Title/Abstract Full Text View citing articles Show Details

Spectrum

CHCl3

245 - 270 nm

EBSTEIN; VAN METER

Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1952 , vol. 41, # 7 p. 372 - 374 Title/Abstract Full Text View citing articles Show Details

Reference

Raman Spectroscopy (1) Description (Raman Spectroscopy)

Reference

Raman

West, Matthew J.; Went, Michael J.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2009 , vol. 71, # 5 p. 1984 - 1988 Title/Abstract Full Text View citing articles Show Details

Fluorescence Spectroscopy (2) Description (Fluorescence Spectroscopy)

Comment (Fluorescence Spectroscopy)

Reference

Spectrum

267.02 - 265.25 nm

Sun; Bernstein

Journal of the American Chemical Society, 1996 , vol. 118, # 21 p. 5086 - 5095 Title/Abstract Full Text View citing articles Show Details

Fluorescence

Lindenbaum et al.

Journal of the Chemical Society, Chemical Communications, 1977 , p. 268 Full Text View citing articles Show Details

Smythies et al.

Experientia, 1971 , vol. 27, p. 62,63 Full Text Show Details

Phosphorescence Spectroscopy (1)


Description (Phosphorescence Spectroscopy)

Reference

Phosphorescence

Harbaugh et al.

Analytical Chemistry, 1974 , vol. 46, p. 1206 Full Text View citing articles Show Details

Bioactivity Pharmacological Data (317) 1 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Cervinka,O. et al.

Collection of Czechoslovak Chemical Communications, 1968 , vol. 33, p. 3551 - 3557 Full Text View citing articles Show Details

Iwai; Tomita; Ide

Chemical and pharmaceutical bulletin, 1965 , vol. 13, # 2 p. 118 - 129 Title/Abstract Full Text View citing articles Show Details

Syva Company

Patent: US3966744 A1, 1976 ; Title/Abstract Full Text Show Details

Laboratoires Laroche Navarron

Patent: US3979456 A1, 1976 ; Title/Abstract Full Text Show Details

Sciortino; Du Ban

Bollettino chimico farmaceutico, 1968 , vol. 107, # 8 p. 506 - 511 Title/Abstract Full Text View citing articles Show Details

Collino

Bollettino chimico farmaceutico, 1969 , vol. 108, # 6 p. 355 - 367 Title/Abstract Full Text View citing articles Show Details

Dalla Vedova; D'Alo

Bollettino Chimico Farmaceutico, 1973 , vol. 112, # 4 p. 273 - 282 Title/Abstract Full Text View citing articles Show Details

E. R. Squibb and Sons, Inc.

Patent: US4131744 A1, 1978 ; Title/Abstract Full Text Show Details

Pesin,V.G.; D'yachenko,S.A.

Chemistry of Heterocyclic Compounds (New York, NY, United States), 1969 , vol. 5, p. 453 - 456 Khimiya Geterotsiklicheskikh Soedinenii, 1969 , vol. 5, # 4 p. 613 - 618 Full Text View citing articles Show Details

O'Connor,M.J. et al.

Journal of the American Chemical Society, 1968 , vol. 90, p. 1744 - 1752 Full Text View citing articles Show Details

Gerlach,D.H.; Holm,R.H.

Journal of the American Chemical Society, 1969 , vol. 91, p. 3457 - 3467 Full Text View citing articles Show Details

Sumitomo Chemical Company, Limited

Patent: US4698421 A1, 1987 ; Title/Abstract Full Text Show Details

Herlinger,H. et al.

Justus Liebigs Annalen der Chemie, 1967 , vol. 706, p. 37 - 46 Full Text View citing articles Show Details

Kindler,K.; Luehrs,K.

Justus Liebigs Annalen der Chemie, 1967 , vol. 707, p. 26 - 34 Full Text View citing articles Show Details

BURGER; STANDRIDGE; ARIENS

Journal of medicinal chemistry, 1963 , vol. 6, p. 221 - 227 Title/Abstract Full Text View citing articles Show Details

ELSLAGER; WEINSTEIN; WORTH

Journal of medicinal chemistry, 1964 , vol. 7, p. 493 - 500 Title/Abstract Full Text View citing articles Show Details

Burger; Zimmerman; Ariens

Journal of medicinal chemistry, 1966 , vol. 9, # 4 p. 469 - 470 Title/Abstract Full Text View citing articles Show Details

Rubinstein; Elming; Fakstorp; Hermansen; Pedersen; Jacobsen

Journal of medicinal chemistry, 1966 , vol. 9, # 6 p. 804 - 809 Title/Abstract Full Text View citing articles Show Details

Gringauz,A.

Journal of Medicinal Chemistry, 1968 , vol. 11, p. 611 - 612 Full Text View citing articles Show Details

Howe; Crowther; Stephenson; Rao; Smith

Journal of medicinal chemistry, 1968 , vol. 11, # 5 p. 1000 - 1008 Title/Abstract Full Text View citing articles Show Details

2 of 317

Comment (Pharmacological Data)

Bioactivities present


Reference

Trepanier; Shriver; Eble

Journal of medicinal chemistry, 1969 , vol. 12, # 2 p. 257 - 260 Title/Abstract Full Text View citing articles Show Details

Howe; McLoughlin; Rao; Smith; Chodnekar

Journal of medicinal chemistry, 1969 , vol. 12, # 3 p. 452 - 458 Title/Abstract Full Text View citing articles Show Details

Kaiser; Leonard; Heil; Lester; Tedeschi; Zirkle

Journal of medicinal chemistry, 1970 , vol. 13, # 5 p. 820 - 826 Title/Abstract Full Text View citing articles Show Details

Verbiscar,A.J.; Abood,L.G.

Journal of Medicinal Chemistry, 1970 , vol. 13, p. 1176 - 1179 Full Text View citing articles Show Details

Shadbolt; Sharpe; Brown; Ashford; Ross

Journal of medicinal chemistry, 1971 , vol. 14, # 9 p. 836 - 842 Title/Abstract Full Text View citing articles Show Details

Rastogi; Anand; Prasad

Journal of medicinal chemistry, 1972 , vol. 15, # 3 p. 286 - 291 Title/Abstract Full Text View citing articles Show Details

Horgan,S.W. et al.

Journal of Medicinal Chemistry, 1975 , vol. 18, p. 315 - 318 Full Text View citing articles Show Details

Najjar; Blake; Benoit; Lu

Journal of Medicinal Chemistry, 1978 , vol. 21, # 6 p. 555 - 558 Title/Abstract Full Text View citing articles Show Details

Schulz,H.

Pharmazie, 1967 , vol. 22, p. 19 - 22 Full Text View citing articles Show Details

Schulz

Die Pharmazie, 1968 , vol. 23, # 5 p. 240 - 242 Title/Abstract Full Text View citing articles Show Details

Reisch; Alfes; Kommert; Jantos; Moellmann; Clasing

Die Pharmazie, 1970 , vol. 25, # 5 p. 331 - 334 Title/Abstract Full Text View citing articles Show Details

Schulz; Jassmann; Bekker

Die Pharmazie, 1971 , vol. 26, # 8 p. 477 - 481 Title/Abstract Full Text View citing articles Show Details

Kotera,K. et al.

Tetrahedron, 1968 , vol. 24, p. 5677 - 5690 Full Text View citing articles Show Details

Beckett,A.H. et al.

Tetrahedron, 1975 , vol. 31, p. 1531 - 1535 Full Text View citing articles Show Details

Beckett,A.H. et al.

Tetrahedron, 1976 , vol. 32, p. 1267 - 1276 Full Text View citing articles Show Details

Schönenberger; Brinkmann

Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft, 1966 , vol. 299, # 11 p. 952 - 965 Title/Abstract Full Text View citing articles Show Details

Murakami,M. et al.

Bulletin of the Chemical Society of Japan, 1962 , vol. 35, p. 11 - 15 Full Text View citing articles Show Details

The General Hospital Corporation

Patent: US4902690 A1, 1990 ; Title/Abstract Full Text Show Details

Laboratoire L. Lafon

Patent: US4980377 A1, 1990 ; Title/Abstract Full Text Show Details

Julia,M.; Tilly,G.

Bulletin de la Societe Chimique de France, 1965 , p. 2175 - 2182 Full Text View citing articles Show Details

3 of 317

Comment (Pharmacological Data)

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Reference

Matsushita Electric Industrial Co., Ltd.

Patent: US5026827 A1, 1991 ; Title/Abstract Full Text Show Details

Weidmann,R.; Horeau,A.

Bulletin de la Societe Chimique de France, 1967 , p. 117 - 124 Full Text View citing articles Show Details

Brunet,M.A. et al.

Bulletin de la Societe Chimique de France, 1967 , p. 2000 - 2003 Full Text View citing articles Show Details

Gelbard,G.; Rumpf,P.

Bulletin de la Societe Chimique de France, 1969 , p. 1161 - 1170 Full Text View citing articles Show Details

Thuong,N.T.; Chabrier,P.

Bulletin de la Societe Chimique de France, 1975 , p. 2083 - 2088 Full Text View citing articles Show Details

Halpern,B. et al.

Chemical Communications (London), 1966 , p. 679 - 680 Full Text View citing articles Show Details


Zamarlik,H. et al.

Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1974 , vol. 278, p. 1385 - 1388 Full Text View citing articles Show Details

Barton,D.H.R. et al.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1974 , p. 732 - 738 Full Text View citing articles Show Details

Shapiro,S.L. et al.

Journal of Organic Chemistry, 1961 , vol. 26, p. 2343 - 2347 Full Text View citing articles Show Details

Diekman,J. et al.

Journal of Organic Chemistry, 1967 , vol. 32, p. 3904 - 3919 Full Text View citing articles Show Details

Yamanouchi Pharmaceutical Co. Ltd.

Patent: US4045482 A1, 1977 ; Title/Abstract Full Text Show Details

Matsushita Electric Industrial Co., Ltd.

Patent: US5243074 A1, 1993 ; Title/Abstract Full Text Show Details

Rossi,D. et al.

Journal of Organic Chemistry, 1979 , vol. 44, # 13 p. 2222 - 2225 Full Text View citing articles Show Details

Campbell,I.G.M.

Journal of the Chemical Society [Section] C: Organic, 1968 , p. 3026 - 3028 Full Text View citing articles Show Details

Boehringer Ingelheim Chemicals, Inc.

Patent: US6399828 B1, 2002 ; Title/Abstract Full Text Show Details

SIBIA Neurosciences, Inc.

Patent: US5594011 A1, 1997 ; Title/Abstract Full Text Show Details

van der Stelt,C. et al.

Recueil des Travaux Chimiques des Pays-Bas, 1965 , vol. 84, p. 1466 - 1477 Full Text Show Details

Van Dijk; Moed

Recueil des Travaux Chimiques des Pays Bas, 1973 , vol. 92, # 12 p. 1281 - 1297 Title/Abstract Full Text View citing articles Show Details

Cotecchia, Susanna

Patent: US2003/217372 A1, 2003 ; Title/Abstract Full Text Show Details

Coutts; Jones; Liu

Biomedical Mass Spectrometry, 1978 , vol. 5, # 6 p. 418 - 422 Title/Abstract Full Text View citing articles Show Details

4 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Yashunskii,V.G.; Vasil'eva,V.G.

J. Gen. Chem. USSR (Engl. Transl.), 1960 , vol. 30, p. 2754 - 2756,2736 - 2738 Full Text View citing articles Show Details

Petyunin,P.A.; Kalugina,Z.G.

J. Gen. Chem. USSR (Engl. Transl.), 1963 , vol. 33, # 9 p. 2835 - 2842,2762 - 2768 Full Text View citing articles Show Details

Zotova,S.A.; Yashunskii,V.G.

Journal of Organic Chemistry USSR (English Translation), 1966 , vol. 2, p. 1842 - 1846 Zhurnal Organicheskoi Khimii, 1966 , vol. 2, # 10 p. 1877 - 1883 Full Text View citing articles Show Details

Babayan,A.T. et al.

Zhurnal Organicheskoi Khimii, 1966 , vol. 2, p. 1974 - 1983,1939 - 1945 Full Text View citing articles Show Details

Kholodov,L.E. et al.

Zhurnal Organicheskoi Khimii, 1967 , vol. 3, # 8 p. 1513 - 1518,1470 - 1474 Full Text View citing articles Show Details

Zotova,S.A.; Yashunskii,V.G.

Zhurnal Organicheskoi Khimii, 1967 , vol. 3, # 10 p. 1889 - 1896,1843 - 1848 Full Text View citing articles Show Details

OREGON HEALTH SCIENCES UNIVERSITY

Patent: WO1992/17568 A1, 1992 ; Title/Abstract Full Text Show Details

THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

Patent: WO1993/8214 A1, 1993 ; Title/Abstract Full Text Show Details

Biela,R. et al.

Journal fuer Praktische Chemie (Leipzig), 1966 , vol. 33, p. 282 - 292 Full Text View citing articles Show Details

Thompson,W.E. et al.

Journal of Pharmaceutical Sciences, 1965 , vol. 54, p. 1819 - 1821 Full Text View citing articles Show Details


Sinsheimer; Keuhnelian

Journal of pharmaceutical sciences, 1966 , vol. 55, # 11 p. 1240 - 1244 Title/Abstract Full Text View citing articles Show Details

Matin; Rowland

Journal of pharmaceutical sciences, 1972 , vol. 61, # 8 p. 1235 - 1240 Title/Abstract Full Text View citing articles Show Details

Gualtieri; Tsakotellis; Skinner; Johnson; Skidmore; Maibach

Journal of pharmaceutical sciences, 1973 , vol. 62, # 5 p. 849 - 851 Title/Abstract Full Text View citing articles Show Details

Beckett; Jones

Journal of Pharmacy and Pharmacology, 1977 , vol. 29, # 7 p. 416 - 421 Title/Abstract Full Text View citing articles Show Details

Pesin,V.G. et al.

Pharmaceutical Chemistry Journal, 1969 , # 12 p. 695 - 696 Khimiko-Farmatsevticheskii Zhurnal, 1969 , # 12 p. 20 - 21 Full Text View citing articles Show Details

Pechenkin,A.G. et al.

Pharmaceutical Chemistry Journal, 1972 , vol. 6, # 7 p. 451 - 453 Khimiko-Farmatsevticheskii Zhurnal, 1972 , vol. 6, # 7 p. 29 - 31 Full Text View citing articles Show Details

UNIVERSITY COLLEGE LONDON

Patent: WO1999/64861 A3, 1999 ; Title/Abstract Full Text Show Details

Kashima,C. et al.

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1975 , p. 665 - 670 Full Text View citing articles Show Details

Kidane, Argaw; Ray, Shimul K.; Bhatt, Padmanabh P.; Bryan, Jones W.

Patent: US2005/53653 A1, 2005 ; Title/Abstract Full Text Show Details

BOEHRINGER INGELHEIM CHEMICALS INC

Patent: JP2005/507936 A, 2005 ; Title/Abstract Full Text Show Details

5 of 317

Comment (Pharmacological Data)

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Reference

RANBAXY LABORATORIES LIMITED

Patent: WO2005/44238 A1, 2005 ; Title/Abstract Full Text Show Details

MEMORY PHARMACEUTICALS CORPORATION

Patent: WO2005/51389 A1, 2005 ; Title/Abstract Full Text Show Details

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Thassu, Deepak; Hafey, Paul

Patent: US2005/142097 A1, 2005 ; Title/Abstract Full Text Show Details

PFIZER PRODUCTS INC.

Patent: WO2005/61506 A1, 2005 ; Title/Abstract Full Text Show Details

PFIZER PRODUCTS INC.

Patent: WO2005/61507 A1, 2005 ; Title/Abstract Full Text Show Details

DESCARTES THERAPEUTICS, INC.

Patent: WO2005/107467 A2, 2005 ; Title/Abstract Full Text Show Details

IRM LLC

Patent: WO2005/113506 A1, 2005 ; Title/Abstract Full Text Show Details

Novo Nordisk, A/S

Patent: US6972294 B1, 2005 ; Title/Abstract Full Text Show Details

Wasson, Allan Anthony

Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details

A. CARLSSON RESEARCH AB

Patent: WO2005/121092 A1, 2005 ; Title/Abstract Full Text Show Details

deCODE Genetics, Inc.

Patent: US2006/29546 A1, 2006 ;


Title/Abstract Full Text Show Details

Cypress Bioscience, Inc.

Patent: US2006/39866 A1, 2006 ; Title/Abstract Full Text Show Details

Renshaw, Perry F.; Cohen, Bruce M.

Patent: US2006/39890 A1, 2006 ; Title/Abstract Full Text Show Details

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

Davis, Michael; Ressler, Kerry J.; Chhatwal, Jasmeer P.; McDevitt, Jason P.

Patent: US2006/84659 A1, 2006 ; Title/Abstract Full Text Show Details

ABBOTT GMBH and CO.KG

Patent: WO2006/40177 A1, 2006 ; Title/Abstract Full Text Show Details

NOVO NORDISK A/S

Patent: WO2006/40329 A1, 2006 ; Title/Abstract Full Text Show Details

Kirk, Randal J.

Patent: US2006/100136 A1, 2006 ; Title/Abstract Full Text Show Details

E.Merck AG

Patent: BE633799 , 1963 ; Chem.Abstr., 1964 , vol. 61, # 4264 Full Text Show Details

6 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Degussa

Patent: DE2061864 , 1971 ; Chem.Abstr., 1972 , vol. 76, # 14103 Full Text Show Details

Hoechst AG

Patent: DE2651083 , 1978 ; Chem.Abstr., 1978 , vol. 89, # 129241 Full Text Show Details

North Amer.Philips Co.,Inc.

Patent: US3046280 , 1962 ; Chem.Abstr., 1963 , vol. 58, # 4606 Full Text Show Details

Nettekoven, Matthias Heinrich; Plancher, Jean-Marc; Roche, Olivier; Rodriguez-Sarmiento, Rosa Maria

Patent: US2006/160855 A1, 2006 ; Title/Abstract Full Text Show Details

CENGENT THERAPEUTICS, INC.

Patent: WO2006/78698 A1, 2006 ; Title/Abstract Full Text Show Details

CLERA INC.

Patent: WO2006/84368 A1, 2006 ; Title/Abstract Full Text Show Details

THE SILVAN S. TOMKINS INSTITUTE

Patent: WO2006/91725 A1, 2006 ; Title/Abstract Full Text Show Details

The Research Foundation of the City University of New York; New York University

Patent: US7112319 B2, 2006 ; Title/Abstract Full Text Show Details

Kulli, John C.

Patent: US2006/257323 A1, 2006 ; Title/Abstract Full Text Show Details

JANSSEN PHARMACEUTICA, N.V; AHNAOU, Abdallah; DRINKENBURG, Wilhelmus, H.I.M.; PALUMBO, Joseph; SPORN, Jonathan

Patent: WO2006/133393 A1, 2006 ; Title/Abstract Full Text Show Details

LABORATORIOS DEL DR. ESTEVE, S.A.

Patent: EP1743643 A1, 2007 ; Title/Abstract Full Text Show Details

Laboratorios del Dr. Esteve S.A.

Patent: EP1745783 A1, 2007 ;


Title/Abstract Full Text Show Details

LABORATORIOS DEL DR. ESTEVE, S.A.

Patent: WO2007/9708 A1, 2007 ; Title/Abstract Full Text Show Details

LABORATORIOS DEL DR. ESTEVE, S.A.

Patent: EP1757588 A1, 2007 ; Title/Abstract Full Text Show Details

PRAECIS PHARMACEUTICALS, INC.

Patent: WO2007/21970 A2, 2007 ; Title/Abstract Full Text Show Details

Cypress Bioscience, Inc.

Patent: US2007/72946 A1, 2007 ; Title/Abstract Full Text Show Details

NOVARTIS AG; NOVARTIS PHARMA GmbH

Patent: WO2007/41366 A1, 2007 ; Title/Abstract Full Text Show Details

Nettekoven, Matthias; Plancher, Jean-Marc; Richter, Hans; Roche, Olivier; Rodriguez Sarmiento, Rosa Maria; Taylor, Sven

Patent: US2007/123526 A1, 2007 ; Title/Abstract Full Text Show Details

IRM LLC

Patent: WO2007/89557 A2, 2007 ; Title/Abstract Full Text Show Details

IRM LLC

Patent: WO2007/89667 A1, 2007 ; Title/Abstract Full Text Show Details

7 of 317

Comment (Pharmacological Data)

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Reference

BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG

Patent: WO2007/93624 A2, 2007 ; Title/Abstract Full Text Show Details

Wyeth

Patent: US2007/225278 A1, 2007 ; Title/Abstract Full Text Show Details

Wyeth

Patent: US2007/225334 A1, 2007 ; Title/Abstract Full Text Show Details

GELESIS, INC.

Patent: WO2007/112436 A2, 2007 ; Title/Abstract Full Text Show Details

Nettekoven, Matthias Heinrich; Roche, Olivier

Patent: US2007/270423 A1, 2007 ; Title/Abstract Full Text Show Details

NOVO NORDISK A/S

Patent: WO2007/135111 A1, 2007 ; Title/Abstract Full Text Show Details

GOUAUX, ERIC; SONG, Langzhou; XIE, Yuli; LANDRY, Donald W.

Patent: US2007/293573 A1, 2007 ; Title/Abstract Full Text Show Details

NOVO NORDISK A/S

Patent: WO2007/144394 A2, 2007 ; Title/Abstract Full Text Show Details

Korea Institute of Science and Technology

Patent: US2008/15163 A1, 2008 ; Title/Abstract Full Text Show Details

Jhamandas, Khem; Milne, Brian

Patent: US2008/20076 A1, 2008 ; Title/Abstract Full Text Show Details

Nettekoven, Matthias; Roche, Olivier

Patent: US2008/32976 A1, 2008 ; Title/Abstract Full Text Show Details

CYPRESS BIOSCIENCE, INC.

Patent: WO2008/19388 A2, 2008 ;


Title/Abstract Full Text Show Details

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

Hebeisen, Paul; Roever, Stephan

Patent: US2008/70931 A1, 2008 ; Title/Abstract Full Text Show Details

Poestges, Reiner; Schneider, Bernd; Ammer, Richard

Patent: US2008/75769 A1, 2008 ; Title/Abstract Full Text Show Details

THERAQUEST BIOSCIENCES, INC.

Patent: WO2008/33351 A2, 2008 ; Title/Abstract Full Text Show Details

BRAINCELLS, INC.

Patent: WO2008/39863 A2, 2008 ; Title/Abstract Full Text Show Details

Tam, Peter Y.; Wilson, Leland F.

Patent: US2008/103179 A1, 2008 ; Title/Abstract Full Text Show Details

Erne; Ramirez

Helvetica Chimica Acta, 1950 , vol. 33, p. 912,915 Full Text View citing articles Show Details

8 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Hey; Williams

Journal of the Chemical Society, 1951 , p. 1527,1529 Full Text View citing articles Show Details

Leffler et al.

Journal of the American Chemical Society, 1951 , vol. 73, p. 2611 Full Text View citing articles Show Details

Dey; Ramanathan

Proceedings of the National Institute of Sciences of India, 1943 , vol. 9, p. 193,222 Full Text Show Details

Gilsdorf; Nord

Journal of the American Chemical Society, 1952 , vol. 74, p. 1837,1841 Full Text View citing articles Show Details

Bellet; Regnier

Bulletin de la Societe Chimique de France, 1953 , p. 756 Full Text View citing articles Show Details

Schusteritz et al.

Arzneimittel Forschung, 1959 , vol. 9, p. 628,629, 632 Full Text View citing articles Show Details

Miles Labor. Inc.

Patent: US2858313 , 1956 ; Full Text Show Details

Morren et al.

Bulletin des Societes Chimiques Belges, 1950 , vol. 59, p. 228,234 Full Text View citing articles Show Details

Ghosh et al.

Journal of the Indian Chemical Society, 1959 , vol. 36, p. 699,702 Full Text View citing articles Show Details

Long et al.

Journal of the American Chemical Society, 1948 , vol. 70, p. 900,901 Full Text Show Details

Am. Home Prod. Corp.

Patent: US2654754 , 1950 ; Full Text Show Details

Lepetit S.p.A.

Patent: US2858317 , 1954 ; Full Text Show Details

Mndshojan et al.

Doklady Akademii Nauk Armyanskoi SSR, 1953 , vol. 17, p. 119,122 Full Text Show Details

Gibbs et al.

Journal of the American Chemical Society, 1951 , vol. 73, p. 5877 Full Text View citing articles Show Details

Wiley et al.

Journal of the American Chemical Society, 1953 , vol. 75, p. 4482 Full Text View citing articles Show Details

Wasil'ewa; Jaschunskii


Khimicheskaya Nauka i Promyshlennost, 1959 , vol. 4, p. 678 Chem.Abstr., 1960 , p. 8793 Full Text Show Details

DAT XUONG

Comptes rendus hebdomadaires des séances de l'Académie des sciences, 1957 , vol. 244, # 1 p. 138 - 140 Title/Abstract Full Text View citing articles Show Details

Wiley et al.

Journal of the American Chemical Society, 1954 , vol. 76, p. 311 Full Text View citing articles Show Details

Kiprianow; Chrapal

Ukrainskii Khimicheskii Zhurnal (Russian Edition), 1950 , vol. 16, # 6 p. 632,634 Chem.Abstr., 1954 , p. 10 635 Full Text Show Details

Fusco; Canonica

Chimica e l'Industria (Milan, Italy), 1950 , vol. 32, p. 208 Full Text Show Details

9 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Haskelberg

Journal of the American Chemical Society, 1948 , vol. 70, p. 2811 Full Text View citing articles Show Details

Bras; Skorodumow

Doklady Akademii Nauk SSSR, 1948 , vol. 59, p. 491 Chem.Abstr., 1948 , vol. 42, p. 6747 Full Text Show Details

Shapiro et al.

Journal of the American Chemical Society, 1958 , vol. 80, p. 6060,6063 Journal of the American Chemical Society, 1959 , vol. 81, p. 203,207 Full Text Show Details

Kiprianow; Frenkel

Ukrainskii Khimicheskii Zhurnal (Russian Edition), 1950 , vol. 16, p. 620,625 Chem.Abstr., 1954 , p. 10635 Full Text Show Details

Blicke; Lilienfeld

Journal of the American Chemical Society, 1943 , vol. 65, p. 2377 Full Text View citing articles Show Details

Stevenson; Williamson

Journal of the American Chemical Society, 1958 , vol. 80, p. 5943,5946 Full Text Show Details

Am.Home Prod.Corp.

Patent: US2654754 , 1950 ; Full Text Show Details

Karrer; Ehrhardt

Helvetica Chimica Acta, 1951 , vol. 34, p. 2202,2208 Full Text Show Details

Hey

Journal of the Chemical Society, 1930 , p. 18,20 Full Text Show Details

Wanag; Veinbergs

Chemische Berichte, 1942 , vol. 75, p. 1558,1567 Full Text Show Details

King et al.

Journal of the Chemical Society, 1954 , p. 1044 Full Text Show Details

Stawrowskaja

Zhurnal Obshchei Khimii, 1955 , vol. 25, p. 193,197;engl.Ausg.S.177,180 Full Text Show Details

Biel et al.

Journal of the American Chemical Society, 1959 , vol. 81, p. 2805,2810, 2813 Full Text View citing articles Show Details

Calo; Evdokimoff

Gazzetta Chimica Italiana, 1950 , vol. 80, p. 456,460 Full Text Show Details

Arbusow et al.

Sb. Statei Obshch. Khim., 1953 , p. 714 Chem.Abstr., 1955 , p. 1072 Full Text Show Details

Machek

Monatshefte fuer Chemie, 1939 , vol. 72, p. 77,88 Full Text Show Details

Chiavarelli et al.

Gazzetta Chimica Italiana, 1957 , vol. 87, p. 427,436 Full Text Show Details

Machek

Monatshefte fuer Chemie, 1941 , vol. 73, p. 180,183, 184 Full Text View citing articles Show Details

Shriner; Child

Journal of the American Chemical Society, 1952 , vol. 74, p. 549 Full Text View citing articles Show Details

Crum; Robinson

Journal of the Chemical Society, 1943 , p. 561,562 Full Text Show Details


10 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Harlay

Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1941 , vol. 213, p. 304 Full Text Show Details

Comm.Solv.Corp.

Patent: US2636901 , 1949 ; Full Text Show Details

Mastagli et al.

Bulletin de la Societe Chimique de France, 1950 , p. 1045 Full Text Show Details

Najer et al.

Bulletin de la Societe Chimique de France, 1959 , p. 352,355 Full Text Show Details

Ratschinskii et al.

Zhurnal Obshchei Khimii, 1958 , vol. 28, p. 2998,3001,3002;engl.Ausg.S.3027,3028,3030 Full Text Show Details

Sekiya

Yakugaku Zasshi, 1950 , vol. 70, p. 553 Chem.Abstr., 1951 , p. 5619 Full Text Show Details

Cannon et al.

Journal of Organic Chemistry, 1957 , vol. 22, p. 1323,1325 Full Text Show Details

Hass et al.

Journal of Organic Chemistry, 1950 , vol. 15, p. 8,13 Full Text Show Details

Patrick; McBee; Hass

Journal of the American Chemical Society, 1946 , vol. 68, p. 1009 Full Text View citing articles Show Details

Alles

Journal of the American Chemical Society, 1932 , vol. 54, p. 271,273 Full Text Show Details

Couturier

Annales de Chimie (Cachan, France), 1938 , vol. <11> 10, p. 559,597 Full Text Show Details

Shapiro et al.

Journal of the American Chemical Society, 1959 , vol. 81, p. 5646,5648 Full Text Show Details

Kieffer; Rumpf

Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1950 , vol. 230, p. 2302 Full Text Show Details

Alexander; Misegades

Journal of the American Chemical Society, 1948 , vol. 70, p. 1315 Full Text View citing articles Show Details

Bobranskii; Drabik

Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1941 , vol. 14, p. 410,413 Chem.Abstr., 1942 , p. 2531 Full Text Show Details

Magidson; Garkuscha

Zhurnal Obshchei Khimii, 1941 , vol. 11, p. 339,341 Chem.Abstr., 1941 , p. 5868 Full Text Show Details

FREEMAN

Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1953 , vol. 42, # 10 p. 621 - 622 Title/Abstract Full Text View citing articles Show Details

Edeleanu

Chemische Berichte, 1887 , vol. 20, p. 618 Full Text Show Details

Leithe

Chemische Berichte, 1932 , vol. 65, p. 660,665 Full Text Show Details

Zenitz; Macks; Moore

Journal of the American Chemical Society, 1947 , vol. 69, p. 1117,1120 Full Text Show Details

11 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Kindler; Hedemann; Schaerfe

Justus Liebigs Annalen der Chemie, 1948 , vol. 560, p. 215,219 Full Text Show Details

Hartung; Munch

Journal of the American Chemical Society, 1931 , vol. 53, p. 1875,1878 Full Text Show Details

Jaeger; van Dijk

Proceedings of the Koninklijke Nederlandse Akademie van Wetenschappen, Series B: Physical Sciences, 1941 , vol. 44, p. 26,36,37 Full Text Show Details

Potapow; Terentew

Zhurnal Obshchei Khimii, 1958 , vol. 28, p. 3323,3325 Anm.


J. Gen. Chem. USSR (Engl. Transl.), 1958 , vol. 28, p. 3349,3351 Anm. Full Text Show Details

Hald; Gad

Dansk Tidsskrift for Farmaci, 1938 , vol. 12, p. 97,103 Full Text Show Details

Woodruff; Conger

Journal of the American Chemical Society, 1938 , vol. 60, p. 465 Full Text View citing articles Show Details

Jaeger; van Dijk

Proceedings of the Koninklijke Nederlandse Akademie van Wetenschappen, Series B: Physical Sciences, 1941 , vol. 71, p. 26,27 Full Text Show Details

Kay-Fries Chem.Inc.

Patent: US2413493 , 1941 ; Full Text Show Details

Vargha; Gyoerffy

Magyar chem.FolyoiratChem.Abstr., 1944 , vol. 50, p. 6,8 Magyar chem.FolyoiratChem.Abstr., 1948 , p. 1219 Full Text Show Details

Purdue Research Found

Patent: US2233823 , 1939 ; Full Text Show Details

Woodruff; Lambooy; Burt

Journal of the American Chemical Society, 1940 , Full Text View citing articles Show Details

Larsson

Svensk Kemisk Tidskrift, 1949 , vol. 61, p. 59 Full Text Show Details

Patrick; McBee; Hass

Journal of the American Chemical Society, 1946 , Full Text View citing articles Show Details

Ritter; Kalish

Journal of the American Chemical Society, 1948 , Organic Syntheses, 1964 , vol. 44, p. 44,45 Full Text View citing articles Show Details

Kornblum; Iffland

Journal of the American Chemical Society, 1949 , Full Text View citing articles Show Details

Buth; Kuelz; Rosenmund

Chemische Berichte, 1939 , vol. 72, p. 19,28 Full Text Show Details

Wyeth Inc.

Patent: US2449638 , 1946 ;

vol. 62, p. 922

vol. 68, p. 1153 vol. 70, p. 4048

vol. 71, p. 2137,2138,2140

Full Text Show Details

Kralt et al.

Recueil des Travaux Chimiques des Pays-Bas, 1958 , vol. 77, p. 177,183 Full Text Show Details

FISCHER; PLEIN

Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1955 , vol. 44, # 5 p. 313 - 316 Title/Abstract Full Text View citing articles Show Details

Chiavarelli; Marini Bettolo

Gazzetta Chimica Italiana, 1951 , vol. 81, p. 89,92 Full Text Show Details

12 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Rapp; Kornew

Ukrainskii Khimicheskii Zhurnal (Russian Edition), 1957 , vol. 23, p. 637,639 Ukrainskii Khimicheskii Zhurnal (Russian Edition), 1959 , vol. 25, p. 351 Chem.Abstr., 1958 , p. 9979,1960 1368 Full Text Show Details

Rebstock et al.

Journal of the American Chemical Society, 1951 , vol. 73, p. 3666,3670 Full Text Show Details

Jung et al.

Journal of the American Chemical Society, 1953 , vol. 75, p. 4664 Full Text View citing articles Show Details

Lewis

British Journal of Pharmacology and Chemotherapy, 1954 , vol. 9, p. 488,490 Full Text Show Details

Pratesi; La Manna

Farmaco, Edizione Scientifica, 1956 , vol. 11, p. 33,41 Full Text Show Details

Murakami; Akagi

Nippon Kagaku Zasshi, 1954 , vol. 75, p. 532,534 Chem.Abstr., 1957 , p. 11242 Full Text Show Details

EBSTEIN; VAN METER

Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1952 , vol. 41, # 7 p. 372 - 374 Title/Abstract Full Text View citing articles Show Details

Steldt; Chen

Journal of the American Pharmaceutical Association (1912-1977), 1954 , vol. 43, p. 477,478


Full Text Show Details

Wilson

Org.Synth.Isotopes, 1958 , p. 512 Full Text Show Details

Temmler-Werke

Patent: DE767186 , 1937 ; DRP/DRBP Org.Chem. Full Text Show Details

Miles Labor.Inc.

Patent: US2797243 , 1953 ; Full Text Show Details

Smith,Kline and French Labor.

Patent: US2608583 , 1949 ; Full Text Show Details

Temmler-Werke

Patent: DE870265 , 1941 ; Full Text Show Details

Larsson

Chalmers Handl., 1950 , # 94 p. 21,26 Full Text Show Details

BASF

Patent: DE848197 , 1944 ; DRP/DRBP Org.Chem. Full Text Show Details

Chatten; Levi

Analytical Chemistry, 1959 , vol. 31, p. 1581,1582,1585 Full Text View citing articles Show Details

Temmler-Werke

Patent: DE871155 , 1938 ; Full Text Show Details

Simon

Zhurnal Obshchei Khimii, 1958 , vol. 28, p. 2586;engl.Ausg.S.2619 Full Text Show Details

Temmler-Werke

Patent: DE865599 , 1943 ; Full Text Show Details

Kiprianow; Molewa

Ukrainskii Khimicheskii Zhurnal (Russian Edition), 1953 , vol. 19, p. 418 Chem.Abstr., 1955 , p. 8146 Full Text Show Details

13 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Smith, Kline and French Labor.

Patent: US2597247 , 1948 ; Full Text Show Details

Kiprianow; Chrapal

Ukrainskii Khimicheskii Zhurnal (Russian Edition), 1950 , vol. 16, p. 627,629 Chem.Abstr., 1954 , p. 10635 Full Text Show Details

Wyeth Inc.

Patent: US2499352 , 1948 ; Full Text Show Details

Tamchyna; Rothova

Chemicke Zvesti, 1958 , vol. 12, p. 284 Chem.Abstr., 1958 , p. 18275 Full Text Show Details

Moed et al.

74<1955>919, 922, 933 Full Text Show Details

Rontondaro

Journal of the Association of Official Agricultural Chemists, 1957 , vol. 40, p. 824,827 Full Text Show Details

E.Lilly and Co.

Patent: US2798094 , 1956 ; Full Text Show Details

Troponwerke

Patent: DE927690 , 1951 ; Full Text Show Details

Schrecker

Journal of Organic Chemistry, 1957 , vol. 22, p. 33 Full Text View citing articles Show Details

Niinobe

Yakugaku Zasshi, 1949 , vol. 69, p. 37 Chem.Abstr., 1949 , p. 9374


Full Text Show Details

Kanao

Yakugaku Zasshi, 1930 , vol. 50, p. 338,343;dtsch.Ref.S.43,46 Chem. Zentralbl., 1930 , vol. 101, # II p. 1695 Full Text Show Details

Imp. Chem. Ind.

Patent: DE750234 , 1938 ; DRP/DRBP Org.Chem. Full Text Show Details

Samdahl; Berg

Bulletin de la Societe Chimique de France, 1951 , p. 94,95 Full Text Show Details

Telc et al.

Journal of Labelled Compounds, 1972 , vol. 8, p. 13,14, 19 Full Text Show Details

Kudrjasova; Chromov-Borisov

Journal of Organic Chemistry USSR (English Translation), 1967 , vol. 3, p. 1076 Zhurnal Organicheskoi Khimii, 1967 , vol. 3, p. 1117 Full Text Show Details

Toldy et al.

Acta Chimica Academiae Scientiarum Hungaricae, 1967 , vol. 53, p. 279 Full Text Show Details

Cholodov et al.

Zhurnal Organicheskoi Khimii, 1967 , vol. 3, p. 1513,1470 Full Text Show Details

Lachman

Journal of Pharmaceutical Sciences, 1965 , vol. 54, p. 1519,1523 Full Text Show Details

Tencheva et al.

Arzneimittel Forschung, 1979 , vol. 29, p. 1331,1333 Full Text Show Details

Kum-Tatt

Journal of Pharmacy and Pharmacology, 1960 , vol. 12, p. 666 Full Text Show Details

14 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Harbaugh et al.

Analytical Chemistry, 1974 , vol. 46, p. 1206 Full Text View citing articles Show Details

Milne et al.

Analytical Chemistry, 1971 , vol. 43, p. 1815,1817 Full Text Show Details

Predmore; Christian

Analytical chemistry, 1976 , vol. 48, # 2 p. 361 - 363 Title/Abstract Full Text View citing articles Show Details

Reisch et al.

Journal of Pharmacy and Pharmacology, 1968 , vol. 20, p. 81,85 Full Text Show Details

Reisch; Alfes; Moellmann

Die Pharmazie, 1968 , vol. 23, # 5 p. 245 - 246 Title/Abstract Full Text View citing articles Show Details

Kracmar; Kracmarova

Cesko-Slovenska Farmacie, 1966 , vol. 15, p. 16,18 Full Text Show Details

Brannon; Hayden

Journal of the Association of Official Agricultural Chemists, 1964 , vol. 47, p. 918,927 Full Text Show Details

Bose; Raychaudhuri

Journal of the Indian Chemical Society, 1961 , vol. 38, p. 217,219 Full Text Show Details

Hoek et al.

Recueil des Travaux Chimiques des Pays-Bas, 1966 , vol. 85, p. 1039,1043 Full Text Show Details

Hayden et al.

Journal - Association of Official Analytical Chemists, 1966 , vol. 49, p. 1109,1119 Full Text Show Details

Kuhnert-Brandstaetter et al.

Pharmaceutica Acta Helvetiae, 1975 , vol. 50, p. 360,364 Full Text Show Details

Abignente; Biniecka Picazio

Acta Poloniae Pharmaceutica - Drug Research, 1977 , vol. 34, # 3 p. 241 - 244 Title/Abstract Full Text View citing articles Show Details

Leader

Analytical Chemistry, 1973 , vol. 45, p. 1700,1706 Full Text Show Details

Sciortino

Bollettino Chimico Farmaceutico, 1966 , vol. 105, p. 223,224 Full Text Show Details

Brandstaetter-Kuhnert et al.

Scientia Pharmaceutica, 1960 , vol. 28, # 1 p. 7,8-15 Chem.Abstr., 1960 , # 17802 Full Text Show Details

Domelsmith; Munchausen; Houk


Journal of Medicinal Chemistry, 1977 , vol. 20, # 10 p. 1346 - 1348 Title/Abstract Full Text View citing articles Show Details

Doyle; Proctor

Journal - Association of Official Analytical Chemists, 1972 , vol. 55, p. 328,329 Full Text Show Details

Budini; Marinangeli

Z. Naturforsch., B: Anorg. Chem., Org. Chem., Biochem., Biophys.,, 1970 , vol. 25, p. 505,507 Full Text Show Details

Luca et al.

Revista de Chimie (Bucharest, Romania), 1979 , vol. 30, p. 72 Full Text Show Details

Seiler; Wiechmann

Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1964 , vol. 337, p. 229,231, 238 Full Text Show Details

15 of 317

16 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Rossi et al.

Helvetica Chimica Acta, 1960 , vol. 43, p. 1046,1052 Full Text Show Details

Furman

Journal - Association of Official Analytical Chemists, 1968 , vol. 51, p. 1111,1115 Full Text Show Details

Garrett, Chembarkar

Journal of Pharmaceutical Sciences, 1968 , vol. 57, p. 1401,1402 Full Text Show Details

Hunneman

Chemiker-Zeitung, 1974 , vol. 98, p. 28,32 Full Text Show Details

Miles; Schenk

Analytical Chemistry, 1973 , vol. 45, p. 130,132 Full Text Show Details

Chatten; Harris

Analytical Chemistry, 1962 , vol. 34, p. 1495,1499 Full Text Show Details

De Silva; Strojny

Analytical Chemistry, 1975 , vol. 47, p. 714,716, 718 Full Text View citing articles Show Details

Mousseron et al.

Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1960 , vol. 250, p. 786 Full Text Show Details

Freiter; Abdallah; Strycker

Journal of medicinal chemistry, 1973 , vol. 16, # 5 p. 510 - 512 Title/Abstract Full Text View citing articles Show Details

Schreiber et al.

Journal of the Chemical Society [Section] B: Physical Organic, 1971 , p. 2154 Full Text View citing articles Show Details

Sinsheimer; Keuhnellan

Journal of Pharmaceutical Sciences, 1966 , vol. 55, p. 1240,1241 Full Text Show Details

Duvall; Koshy; Pyles

Journal of pharmaceutical sciences, 1965 , vol. 54, # 4 p. 607 - 611 Title/Abstract Full Text View citing articles Show Details

Lindenbaum et al.

Journal of the Chemical Society, Chemical Communications, 1977 , p. 268 Full Text View citing articles Show Details

Lanyi et al.

Chemische Berichte, 1967 , vol. 100, # 9 p. 3045 Full Text Show Details

Humbert; Laurent

Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1971 , vol. 272, p. 1165 Full Text Show Details

Landor et al.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1974 , p. 1294,1299 Full Text Show Details

Landor et al.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1974 , p. 1902 Full Text Show Details

Potapow; Terent'ew

J. Gen. Chem. USSR (Engl. Transl.), 1961 , vol. 31, p. 1003,927 Chem.Abstr., 1961 , # 23389 Full Text Show Details

Griffin; Banker

Journal of Pharmaceutical Sciences, 1967 , vol. 56, p. 1098,1099 Full Text Show Details

Sung; Parker

Zeitschrift fuer Naturforschung, C: Journal of Biosciences, 1974 , vol. 29, p. 122,124 Full Text Show Details

Comment (Pharmacological Data)

Bioactivities present


17 of 317

Reference

Krieg

Arzneimittel-Forschung, 1974 , vol. 24, # 2 p. 133 - 134 Title/Abstract Full Text View citing articles Show Details

Kliger et al.

Neftekhimiya, 1977 , vol. 17, p. 602,605 Chem.Abstr., 1978 , vol. 88, # 22040 Full Text Show Details

Gal et al.

Acta Pharmaceutica Suecica, 1977 , vol. 14, p. 335,340 Full Text Show Details

Brandenberger

Pharmaceutica Acta Helvetiae, 1970 , vol. 45, p. 394,406 Full Text Show Details

Prajsnar

Zeszyty Naukowe Politechniki Slaskiej, Chemia, 1963 , vol. 20, p. 1,72 Full Text Show Details

Cooper; Macnicol

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1978 , p. 760 Full Text Show Details

Ehrsson; Broetel

Acta Pharmaceutica Suecica, 1971 , vol. 8, p. 591,596 Full Text Show Details

Beckett; Moffat

The Journal of pharmacy and pharmacology, 1969 , vol. 21, p. Suppl:144S+ Title/Abstract Full Text View citing articles Show Details

Christol et al.

Bulletin de la Societe Chimique de France, 1961 , p. 2317 Full Text Show Details

Nace; King

Journal of Medicinal and Pharmaceutical Chemistry, 1962 , vol. 5, p. 1316,1321 Full Text Show Details

Riley; Brier

Journal of medicinal chemistry, 1972 , vol. 15, # 11 p. 1187 - 1188 Title/Abstract Full Text Show Details

Mihailova; Testa

European Journal of Medicinal Chemistry, 1978 , vol. 13, # 1 p. 49 - 52 Title/Abstract Full Text View citing articles Show Details

Arsenault et al.

Analytical Chemistry, 1971 , vol. 43, p. 1720 Full Text View citing articles Show Details

Serck-Hanssen

Archives of Mass Spectral Data, 1971 , vol. 2, p. 760 Full Text Show Details

Smith et al.

Journal of Pharmaceutical Sciences, 1976 , vol. 65, p. 412,413, 414 Full Text View citing articles Show Details

Pullman et al.

Journal of Medicinal Chemistry, 1972 , vol. 15, p. 17,20 Full Text Show Details

Lambert et al.

Organic Magnetic Resonance, 1975 , vol. 7, p. 266,272 Full Text Show Details

Blang; Huang

Journal of Pharmaceutical Sciences, 1973 , vol. 62, p. 652 Full Text View citing articles Show Details

Blang; Huang

Journal of Pharmaceutical Sciences, 1972 , vol. 61, p. 1770,1772, 1774 Full Text View citing articles Show Details

Cartoni et al.

Bollettino Chimico Farmaceutico, 1976 , vol. 115, p. 347,350 Full Text Show Details

Comment (Pharmacological Data)

Bioactivities present

Reference

Kamei et al.

Chemical and Pharmaceutical Bulletin, 1973 , vol. 21, p. 1996,2000 Full Text Show Details

Boulassier; Chatelus

Annales de Chimie (Cachan, France), 1972 , vol. 7, # 14 p. 169,172,173 Full Text Show Details

Bergin; Carlstroem

Acta Crystallographica, Section B: Structural Crystallography and Crystal Chemistry, 1971 , vol. 27, p. 2146,2151 Full Text Show Details

Fontani; Morandini

The Journal of pharmacy and pharmacology, 1970 , vol. 22, # 6 p. 411 - 413 Title/Abstract Full Text View citing articles Show Details

Donike

Journal of chromatography, 1973 , vol. 78, # 2 p. 273 - 279 Title/Abstract Full Text View citing articles Show Details

Cervinka et al.

Zeitschrift fuer Chemie (Stuttgart, Germany), 1968 , vol. 8, p. 24 Full Text Show Details

Thomis; Kotionis

Analytica Chimica Acta, 1956 , vol. 14, p. 457


Chem.Abstr., 1957 , # 5624 Full Text View citing articles Show Details

ALLEVA

Journal of medicinal chemistry, 1963 , vol. 6, p. 621 - 624 Title/Abstract Full Text View citing articles Show Details

Zapior; Czapkiewicz

Roczniki Chemii, 1962 , vol. 36, p. 1863,1866,1867 Chem.Abstr., vol. 58, # 11986 Full Text Show Details

Warren et al.

Journal - Association of Official Analytical Chemists, 1971 , vol. 54, p. 1179,1181,1186,1188 Full Text View citing articles Show Details

Ruckpaul et al.

Croatica Chemica Acta, 1977 , vol. 49, p. 339,343 Full Text Show Details

Rein et al.

Croatica Chemica Acta, 1977 , vol. 49, p. 251,253, 254, 256, 257 Full Text Show Details

Beckett et al.

Journal of Pharmacy and Pharmacology, 1967 , vol. 19, p. 273,291 Full Text Show Details

Thies; Ermer

Naturwissenschaften, 1962 , vol. 49, p. 37 Full Text View citing articles Show Details

Bloor; Morrinson

Journal of Pharmacy and Pharmacology, 1972 , vol. 24, p. 927,928,931,932 Full Text View citing articles Show Details

Modin; Johansson

Acta Pharmaceutica Suecica, 1971 , vol. 8, p. 561,565 Full Text Show Details Smythies et al.

Experientia, 1971 , vol. 27, p. 62,63 Full Text Show Details

Neville et al.

Journal of Medicinal Chemistry, 1971 , vol. 14, p. 717,718 Full Text Show Details

Yamada et al.

Tetrahedron Letters, 1976 , p. 1001 Full Text View citing articles Show Details

Hess et al.

Pharmazie, 1976 , vol. 31, p. 452,453 Full Text Show Details

18 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Kumbar

Journal of Medicinal Chemistry, 1976 , vol. 19, p. 1232,1234 Full Text Show Details

Lambert et al.

Spectroscopy Letters, 1975 , vol. 8, p. 509,511 Full Text Show Details

Klosa

Journal fuer Praktische Chemie (Leipzig), 1967 , vol. 35, p. 319 Full Text Show Details

Milstein

Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 339 Full Text Show Details

Burger; Siuda

Journal of medicinal chemistry, 1969 , vol. 12, # 2 p. 317 - 320 Title/Abstract Full Text Show Details

Kotera et al.

Tetrahedron Letters, 1967 , p. 841 Full Text Show Details

Soc. Chim. Org. Biol.

Patent: FRM79 , 1960 ; Chem.Abstr., 1963 , vol. 58, # 10302g Full Text Show Details

Donike; Iffland; Jaenicke

Arzneimittel-Forschung, 1974 , vol. 24, # 4 p. 556 - 560 Title/Abstract Full Text View citing articles Show Details

Bruderer et al.

Helvetica Chimica Acta, 1967 , vol. 50, p. 1917 Full Text Show Details

Dumpis, M. A.; Kudryashova, N. I.; Veresova, M. A.

Journal of Organic Chemistry USSR (English Translation), 1989 , vol. 25, # 7.2 p. 1332 - 1337 Zhurnal Organicheskoi Khimii, 1989 , vol. 25, # 7 p. 1477 - 1482 Title/Abstract Full Text Show Details

Harsy, Stephen G.

Tetrahedron, 1990 , vol. 46, # 21 p. 7403 - 7412 Title/Abstract Full Text View citing articles Show Details

Kabalka, George W.; Laila Guindi; Varma, Rajender S.

Tetrahedron, 1990 , vol. 46, # 21 p. 7443 - 7457 Title/Abstract Full Text View citing articles Show Details

Kadushkin; Golovko; Granik; Glushkov; Parimbetova; Parshin; Mashkovskii


Pharmaceutical Chemistry Journal, 1990 , vol. 23, # 10 p. 803 - 806 Title/Abstract Full Text View citing articles Show Details

Glennon, Richard A.; Smith, J. Doyle; Ismaiel, Abd M.; El-Ashmawy, Mahmoud; Battaglia, George; Fisher, James B.

Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1094 - 1098 Title/Abstract Full Text View citing articles Show Details

Vogt Chr.; Jira Th.; Beyrich Th.

Pharmazie, 1990 , vol. 45, # 9 p. 691 - 691 Title/Abstract Full Text View citing articles Show Details

Gee, Antony; Langstroem, Bengt

Acta Chemica Scandinavica, 1991 , vol. 45, # 4 p. 431 - 435 Title/Abstract Full Text Show Details

Johnson; Frescas; Oberlender; Nichols

Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1662 - 1668 Title/Abstract Full Text View citing articles Show Details

Solomina, L. P.; Sarkisyan, A. B.; Pirdzhanov, L. Sh.; Arzanunts, E. M.; Sarkisyan, I. S.; et al.

Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 4 p. 272 - 275 Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 4 p. 40 - 42 Title/Abstract Full Text View citing articles Show Details

Inaba, Takashi; Fujita, Makoto; Ogura, Katsuyuki

Journal of Organic Chemistry, 1991 , vol. 56, # 3 p. 1274 - 1279 Title/Abstract Full Text View citing articles Show Details

Mori; Ishiyama; Akita; Suzuki; Mitsuoka; Oishi

Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 12 p. 3449 - 3451 Title/Abstract Full Text View citing articles Show Details

19 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Ershov, L. V.; Granik, V. G.

Chemistry of Heterocyclic Compounds (New York, NY, United States), 1985 , vol. 21, # 5 p. 544 - 547 Khimiya Geterotsiklicheskikh Soedinenii, 1985 , vol. 21, # 5 p. 646 - 649 Title/Abstract Full Text View citing articles Show Details

Valenta, Vladimir; Vlkova, Marie; Holubek, Jiri; Metysova, Jirina; Protiva, Miroslav

Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 7 p. 1979 - 1994 Title/Abstract Full Text Show Details

Jilek, Jiri; Urban, Jiri; Taufmann, Petr; Holubek, Jiri; Dlabac, Antonin; et al.

Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 7 p. 1995 - 2008 Title/Abstract Full Text Show Details

Machkova, Zuzana; Zavada, Jiri

Collection of Czechoslovak Chemical Communications, 1981 , vol. 46, # 4 p. 833 - 849 Title/Abstract Full Text Show Details

Sycheva, T. V.; Yakhontov, L. N.

Chemistry of Heterocyclic Compounds (New York, NY, United States), 1985 , vol. 21, # 1 p. 68 - 72 Khimiya Geterotsiklicheskikh Soedinenii, 1985 , vol. 21, # 1 p. 84 - 88 Title/Abstract Full Text View citing articles Show Details

Vlasova, M. I.; Kogan, N. A.

Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , p. 43 - 48 Khimiya Geterotsiklicheskikh Soedinenii, 1983 , vol. 19, # 1 p. 49 - 54 Title/Abstract Full Text View citing articles Show Details

Pirkle, William H.; Simmons, Kirk A.

Journal of Organic Chemistry, 1981 , vol. 46, # 16 p. 3239 - 3246 Title/Abstract Full Text View citing articles Show Details

Rangnekar, V. M.; Lokhande, S. R.; Bhamaria, R. P.; Khadse, B. G.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 10 p. 1070 - 1071 Title/Abstract Full Text Show Details

Agarwal, Shiv K.; Kumar, Yatendra; Saxena, Anil K.; Jain, Padam C.; Anand, Nitya

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 5 p. 435 - 439 Title/Abstract Full Text Show Details

Nagarajan; Shenoy; Talwalker

Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1989 , vol. 28, # 4 p. 326 - 332 Title/Abstract Full Text View citing articles Show Details

Ali, Abdel Rahman el Nasser Ossman

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 8 p. 762 - 765 Title/Abstract Full Text Show Details

Zappey, Herman; Fokkens, Roel H.; Ingemann, Steen; Nibbering, Nico M. M.; Florencio, Helena

Organic Mass Spectrometry, 1991 , vol. 26, # 6 p. 587 - 594 Title/Abstract Full Text Show Details

Kadushkin, A. V.; Nesterova, I. N.; Golovko, T. V.; Nikolaeva, I. S.; Pushkina, T. V.; et al.

Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 12 p. 875 - 881 Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 12 p. 18 - 22 Title/Abstract Full Text View citing articles Show Details

Glennon, Richard A.; Raghupathi, Reva; Bartyzel, Piotr; Teitler, Milt; Leonhardt, Sigrun

Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 734 - 740 Title/Abstract Full Text View citing articles Show Details

Wessling, Michael; Schaefer, Hans J.

Chemische Berichte, 1991 , vol. 124, # 10 p. 2303 - 2306 Title/Abstract Full Text Show Details

Hornback, Joseph M.; Murugaverl, Balasingam

Tetrahedron Letters, 1989 , vol. 30, # 43 p. 5853 - 5856 Title/Abstract Full Text View citing articles Show Details

Vejdelek, Zdenek; Nemec, Jiri; Protiva, Miroslav

Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 7 p. 1487 - 1493 Title/Abstract Full Text Show Details

Leclerc, Gerard; Decker, Nicole; Schwartz, Jean

Journal of Medicinal Chemistry, 1982 , vol. 25, # 6 p. 709 - 714


Title/Abstract Full Text View citing articles Show Details

Hathaway; Nichols; Yim

Journal of Medicinal Chemistry, 1982 , vol. 25, # 5 p. 535 - 538 Title/Abstract Full Text View citing articles Show Details

Grunewald, Gary L.; Monn, James A.; Rafferty, Michael F,; Borchardt, Ronald T.; Krass, Polina

Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1248 - 1250 Title/Abstract Full Text View citing articles Show Details

20 of 317

Show next 20

21 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Kwiatkowski; Jeganathan; Tobin; Watt

Synthesis, 1989 , # 12 p. 946 - 949 Title/Abstract Full Text View citing articles Show Details

Kivokurtseva, L. N.

Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 11 p. 797 - 798 Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 11 p. 78 - 80 Title/Abstract Full Text View citing articles Show Details

Taube, D. O.; Lukinskaya, E. P.; Passet, B. V.

Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 1 p. 50 - 54 Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 1 p. 62 - 67 Title/Abstract Full Text View citing articles Show Details

Saxena; Bhalla; Verma; Shanker

Journal of the Indian Chemical Society, 1991 , vol. 68, # 3 p. 142 - 143 Title/Abstract Full Text View citing articles Show Details

Vecchietti; Clarke; Colle; Dondio; Giardina; Petrone; Sbacchi

Journal of Medicinal Chemistry, 1992 , vol. 35, # 16 p. 2970 - 2978 Title/Abstract Full Text View citing articles Show Details

Harsche; Oelschlaeger; Engel

Archiv der Pharmazie, 1992 , vol. 325, # 9 p. 593 - 595 Title/Abstract Full Text View citing articles Show Details

Oelschlager; Harsche; Engel

Archiv der Pharmazie, 1991 , vol. 324, # 9 p. 543 - 546 Title/Abstract Full Text View citing articles Show Details

Dozorova, E. N.; Kadushkin, A. V.; Bogdanova, G. A.; Solov'eva, N. P.; Granik, V. G.

Chemistry of Heterocyclic Compounds (New York, NY, United States), 1991 , vol. 27, # 6 p. 590 - 594 Khimiya Geterotsiklicheskikh Soedinenii, 1991 , vol. 27, # 6 p. 754 - 758 Title/Abstract Full Text View citing articles Show Details

Shahidi, Fereidoon

Canadian Journal of Chemistry, 1987 , vol. 65, p. 1924 - 1926 Title/Abstract Full Text Show Details

Toda, Fumio; Mori, Koji; Okada, Jyoji; Node, Manabu; Itoh, Akichika; et al.

Chemistry Letters, 1988 , p. 131 - 134 Title/Abstract Full Text Show Details

Amlaiky; Leclerc; Decker; Schwartz

European Journal of Medicinal Chemistry, 1984 , vol. 19, # 4 p. 341 - 346 Title/Abstract Full Text View citing articles Show Details

Hess; Ziebig

Pharmazie, 1981 , vol. 36, # 4 p. 253 - 256 Title/Abstract Full Text View citing articles Show Details

Hamdy; Fahim

Pharmazie, 1982 , vol. 37, # 3 p. 206 - 208 Title/Abstract Full Text View citing articles Show Details

Hess, Ulrich; Dunkel, Silke

Zeitschrift fuer Chemie (Stuttgart, Germany), 1988 , vol. 28, # 10 p. 372 - 373 Title/Abstract Full Text Show Details

Hess; Marleneziebig

Pharmazie, 1982 , vol. 37, # 2 p. 107 - 111 Title/Abstract Full Text View citing articles Show Details

Glennon; Liebowitz; Anderson III

Journal of Medicinal Chemistry, 1980 , vol. 23, # 3 p. 294 - 299 Title/Abstract Full Text View citing articles Show Details

Clark; Wells; Sansom; et al.

Journal of Medicinal Chemistry, 1984 , vol. 27, # 6 p. 779 - 782 Title/Abstract Full Text View citing articles Show Details

Andrews; Craik; Martin

Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1648 - 1657 Title/Abstract Full Text View citing articles Show Details

El-Torki, Farid M.; Jacobus John

Journal of Organic Chemistry, 1985 , vol. 50, # 8 p. 1314 - 1316 Title/Abstract Full Text View citing articles Show Details

Harris; Middlemiss; Mills; Gower; Tyers

Journal of Medicinal Chemistry, 1983 , vol. 26, # 1 p. 55 - 60 Title/Abstract Full Text View citing articles Show Details

Hide facts Comment (Pharmacological Data)

Bioactivities present

Reference

Sarkisyan, A. B.; Solomina, L. P.; Pirdzhanov, L. Sh.; Markaryan, E. A.; Arzanunt, E. M.; et al.

Pharmaceutical Chemistry Journal, 1985 , vol. 19, # 4 p. 256 - 258 Khimiko-Farmatsevticheskii Zhurnal, 1985 , vol. 19, # 4 p. 423 - 425 Title/Abstract Full Text View citing articles Show Details


Kudryashova, N. I.; Dumpis, M. A.; Sapronov, N. S.; Shabanov, P. D.

Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 9 p. 669 - 672 Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 9 p. 1067 - 1070 Title/Abstract Full Text View citing articles Show Details

Balayan, R. S.; Akopyan, M. G.; Vartanyan, R. M.; Kaltrikyan, A. A.; Avakyan, O. M.; et al.

Pharmaceutical Chemistry Journal, 1985 , vol. 19, # 8 p. 558 - 562 Khimiko-Farmatsevticheskii Zhurnal, 1985 , vol. 19, # 8 p. 956 - 960 Title/Abstract Full Text View citing articles Show Details

Gevorkyan, K. A.; Papayan, G. L.; Shirinyan, E. A.; Atayan, T. K.; Vorskanyan, A. S.

Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 7 p. 484 - 487 Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 7 p. 806 - 808 Title/Abstract Full Text View citing articles Show Details

Modnikova, G. A.; Titkova, R. M.; Glushkov, R. G.; Sokolova, A. S.; Silin, V. A.; Chernov, V. A.

Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 2 p. 135 - 141 Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 2 p. 185 - 191 Title/Abstract Full Text View citing articles Show Details

Filitis, L. N.; Akalaeva, T. V.; Amel'kin, O. Yu.; Bokanov, A. I.; Ivanov, P. Yu.; Shvedov, V. I.

Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 10 p. 780 - 785 Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 10 p. 1217 - 1222 Title/Abstract Full Text View citing articles Show Details

Piotrovskii, L. B.; Dumpis, M. A.; Shabanov, P. D.

Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 7 p. 460 - 463 Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 7 p. 799 - 802 Title/Abstract Full Text View citing articles Show Details

Tugusheva, N. Z.; Ershov, L. V.; Granik, V. G.; Shvarts, G. Ya.; Syubaev, R. D.; Mashkovskii, M. D.

Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 7 p. 483 - 488 Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 7 p. 830 - 835 Title/Abstract Full Text View citing articles Show Details

Rangnekar, V. M.; Bhamaria, R. P.; Khadse, B. G.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 342 - 344 Title/Abstract Full Text Show Details

Das, Michael; Chaudhuri, Subhankar; Ray, Manotosh R.; Chakravorti, S. S.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 1072 - 1078 Title/Abstract Full Text Show Details

Caldirola, PM; Goot, H van der; Timmerman, H

European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 571 - 579 Title/Abstract Full Text View citing articles Show Details

Meincke; Kottke; Beyrich

Pharmazie, 1992 , vol. 47, # 9 p. 697 - 699 Title/Abstract Full Text View citing articles Show Details

Frison, G.; Castagna, F.; Brusini, G.; Tedeschi, L.; Seraglia, R.; Traldi, P.

Organic Mass Spectrometry, 1992 , vol. 27, # 11 p. 1284 - 1288 Title/Abstract Full Text Show Details

Meincke; Kottke; Beyrich

Pharmazie, 1992 , vol. 47, # 10 p. 780 - 783 Title/Abstract Full Text View citing articles Show Details

Shivanyuk; Losev; Vargashkin; Bobkov; Lozinskii

Pharmaceutical Chemistry Journal, 1992 , vol. 26, # 5 p. 430 - 432 Title/Abstract Full Text View citing articles Show Details

Border, Corinne L.; Craik, David J.; Shehan, B. Philip

Magnetic Resonance in Chemistry, 1993 , vol. 31, # 3 p. 222 - 230 Title/Abstract Full Text Show Details

Castro, C. E.; Jamin, Mary; Yokoyama, W.; Wade, Ruth

Journal of the American Chemical Society, 1986 , vol. 108, # 14 p. 4179 - 4187 Title/Abstract Full Text View citing articles Show Details

Klosa

Arzneimittel-Forschung/Drug Research, 1980 , vol. 30, # 2 p. 228 - 231 Title/Abstract Full Text View citing articles Show Details

Mourad, M. Soubei; Varma, Rajender S.; Kabalka, George W.

Synthetic Communications, 1984 , vol. 14, # 12 p. 1099 - 1104 Title/Abstract Full Text Show Details

Todd; Stafford Jr.; Kelley; Syka; Cooks; Louris

Analytical Chemistry, 1987 , vol. 59, # 13 p. 1677 - 1685 Title/Abstract Full Text View citing articles Show Details

22 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Athanasiou-Malaki; Koupparis; Hadjiioannou

Analytical Chemistry, 1989 , vol. 61, # 13 p. 1358 - 1363 Title/Abstract Full Text View citing articles Show Details

Kuliev, A. B.; Abdullaeva, M. I.; Akhadov, N. O.

J. Appl. Chem. USSR (Engl. Transl.), 1984 , vol. 57, # 8 p. 1835 - 1838,1699 - 1701 Title/Abstract Full Text Show Details

Glennon, Richard A.; McKenney, J. D.; Lyon, Robert A.; Titeler, Milt

Journal of Medicinal Chemistry, 1986 , vol. 29, # 2 p. 194 - 199 Title/Abstract Full Text View citing articles Show Details

Caroon, Joan M.; Clark, Robin D.; Kluge, Arthur F.; Lee, Chi-Ho; Strosberg, Arthur M.

Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1426 - 1433 Title/Abstract Full Text View citing articles Show Details

Hamada, Akihiko; Chang, Yu An; Uretsky, Norman; Miller, Duane D.

Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 675 - 680 Title/Abstract Full Text View citing articles Show Details

Butler; Nordin; L'Italien; Zweisler; Poschel; Marriott

Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 684 - 691


Title/Abstract Full Text View citing articles Show Details

Rafferty, Michael F.; Wilson, David S.; Monn, James A.; Krass, Polina; Borchardt, Ronald T.; Grunewald, Gary L.

Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1198 - 1204 Title/Abstract Full Text View citing articles Show Details

Rafferty; Borchardt; Grunewald

Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1204 - 1208 Title/Abstract Full Text View citing articles Show Details

Blume

Arzneimittel-Forschung/Drug Research, 1981 , vol. 31, # 6 p. 994 - 997 Title/Abstract Full Text View citing articles Show Details

Jacquot; Rapin

Arzneimittel-Forschung/Drug Research, 1980 , vol. 30, # 5 p. 776 - 779 Title/Abstract Full Text View citing articles Show Details

Ruecker; Neugebauer

Archiv der Pharmazie, 1986 , vol. 319, # 4 p. 317 - 324 Title/Abstract Full Text View citing articles Show Details

Bell, Harold M.; Bowles, Deborah B.; Senese, Fred

Organic Magnetic Resonance, 1981 , vol. 16, # 4 p. 285 - 289 Title/Abstract Full Text Show Details

Schonenberger; Brossi

Helvetica Chimica Acta, 1986 , vol. 69, # 6 p. 1486 - 1497 Title/Abstract Full Text View citing articles Show Details

Leclerc; Decker; Schwartz

Arzneimittel-Forschung/Drug Research, 1985 , vol. 35, # 9 p. 1357 - 1367 Title/Abstract Full Text View citing articles Show Details

Pittner

Arzneimittel-Forschung/Drug Research, 1983 , vol. 33, # 1 A p. 13 - 25 Title/Abstract Full Text View citing articles Show Details

Jahn; Adrian; Ismail; Michos

Arzneimittel-Forschung/Drug Research, 1983 , vol. 33, # 5 p. 726 - 730 Title/Abstract Full Text View citing articles Show Details

Blume

Arzneimittel-Forschung/Drug Research, 1981 , vol. 31, # 5 p. 805 - 809 Title/Abstract Full Text View citing articles Show Details

Javaid; Davis

Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 7 p. 813 - 815 Title/Abstract Full Text View citing articles Show Details

Smith, Roger A.; White, Robert L.; Krantz, Allen

Journal of Medicinal Chemistry, 1988 , vol. 31, # 8 p. 1558 - 1566 Title/Abstract Full Text View citing articles Show Details

Varma, Rajender S.; Kabalka, George W.

Synthetic Communications, 1985 , vol. 15, # 9 p. 843 - 848 Title/Abstract Full Text Show Details

23 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

McClure; Baldwin; Randall; Lyon; Mensler; Lundell; Raab; Gross; Risley; Sweet; Williams

Journal of Medicinal Chemistry, 1983 , vol. 26, # 5 p. 649 - 657 Title/Abstract Full Text View citing articles Show Details

Glennon; Young; Benington; Morin

Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1163 - 1168 Title/Abstract Full Text View citing articles Show Details

Baldwin, Jack E.; Adlington, Robert M.; Newington, Ian M.

Journal of the Chemical Society, Chemical Communications, 1986 , # 2 p. 176 - 178 Title/Abstract Full Text View citing articles Show Details

Little; Rees

Journal of Pharmacy and Pharmacology, 1980 , vol. 32, # 11 p. 751 - 756 Title/Abstract Full Text View citing articles Show Details

Wermuth; Schlewer; Bourguignon; Maghioros; Bouchet; Moire; Kan; Worms; Biziere

Journal of Medicinal Chemistry, 1989 , vol. 32, # 3 p. 528 - 537 Title/Abstract Full Text View citing articles Show Details

Depin; Betbeder-Matibet; Bonhomme; Muller; Berthelon

Arzneimittel-Forschung/Drug Research, 1985 , vol. 35, # 11 p. 1655 - 1662 Title/Abstract Full Text View citing articles Show Details

Testa; Salvesen

Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 5 p. 497 - 501 Title/Abstract Full Text View citing articles Show Details

Tsai, Ruey-Shiuan; Fan, Weizheng; El Tayar, Nabil; Carrupt, Pierre-Alain; Testa, Bernard; Kier, Lemont B.

Journal of the American Chemical Society, 1993 , vol. 115, # 21 p. 9632 - 9639 Title/Abstract Full Text View citing articles Show Details

Caldirola, P.; Zandberg, P.; Mannhold, R.; Timmerman, H.

European Journal of Medicinal Chemistry, 1993 , vol. 28, # 7-8 p. 555 - 568 Title/Abstract Full Text View citing articles Show Details

Nakazawa, Hidetsugu; Kumagai, Hidehiko; Yamada, Hideaki

Agricultural and Biological Chemistry, 1985 , vol. 49, # 1 p. 159 - 166 Title/Abstract Full Text Show Details

Comai; Sullivan

Journal of Pharmaceutical Sciences, 1982 , vol. 71, # 4 p. 418 - 421 Title/Abstract Full Text View citing articles Show Details

Borgna; Vicarini; Carmellino; Pagani

Farmaco, Edizione Scientifica, 1983 , vol. 38, # 10 p. 801 - 810 Title/Abstract Full Text View citing articles Show Details

Tajana; Pennini; Nardi

Farmaco, Edizione Scientifica, 1980 , vol. 35, # 3 p. 181 - 190


Title/Abstract Full Text View citing articles Show Details

Rucker; Neugebauer; Heiden

Arzneimittel-Forschung/Drug Research, 1988 , vol. 38, # 4 p. 497 - 501 Title/Abstract Full Text View citing articles Show Details

Nakazawa, Hidetsugu; Kumagai, Hidehiko; Yamada, Hideaki

Agricultural and Biological Chemistry, 1981 , vol. 45, # 11 p. 2543 - 2552 Title/Abstract Full Text Show Details

Saxena; Verma; Shanker

Arzneimittel-Forschung/Drug Research, 1994 , vol. 44, # 6 p. 766 - 769 Title/Abstract Full Text View citing articles Show Details

Kuliev; Kurbanov; Mamedov

Journal of applied chemistry of the USSR, 1985 , vol. 58, # 1 pt 2 p. 139 - 142 Title/Abstract Full Text View citing articles Show Details

Hanquet, Gilles; Lusinchi, Xavier

Tetrahedron, 1994 , vol. 50, # 42 p. 12185 - 12200 Title/Abstract Full Text View citing articles Show Details

Hulst, Ron; Zijlstra, Robert W. J.; Vries, N. Koen de; Feringa, Ben L.

Tetrahedron: Asymmetry, 1994 , vol. 5, # 9 p. 1701 - 1710 Title/Abstract Full Text View citing articles Show Details

Donner

Tetrahedron Letters, 1995 , vol. 36, # 8 p. 1223 - 1226 Title/Abstract Full Text View citing articles Show Details

24 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Vega; Soledad Gil; Darias; Sanchez Mateo; Exposito

Pharmazie, 1995 , vol. 50, # 1 p. 27 - 33 Title/Abstract Full Text View citing articles Show Details

Fitzgerald; Reid

Journal of Pharmacy and Pharmacology, 1994 , vol. 46, # 10 p. 826 - 832 Title/Abstract Full Text View citing articles Show Details

Buzas; Champagnac; Dehnel; Lavielle; Pommier

Journal of Medicinal Chemistry, 1980 , vol. 23, # 2 p. 149 - 153 Title/Abstract Full Text View citing articles Show Details

Neugebauer

Pharmazie, 1995 , vol. 50, # 3 p. 201 - 206 Title/Abstract Full Text View citing articles Show Details

Seres, J.; Daroczi-Csuka, K.; Gall-Istok, K.; Simon, K.; Szilagyi, I.

Journal of Chemical Research, Miniprint, 1995 , # 1 p. 244 - 273 Title/Abstract Full Text Show Details

Schultz, Arthur G.; Kirincich, Steven J.; Rahm, Rainer

Tetrahedron Letters, 1995 , vol. 36, # 26 p. 4551 - 4554 Title/Abstract Full Text View citing articles Show Details

Acs, Maria; Kozma, David; Fogassy, Elemer

ACH - Models in Chemistry, 1995 , vol. 132, # 3 p. 475 - 478 Title/Abstract Full Text Show Details

Bell; Cantrell; Hogberg; Jaskunas; Johansson; Jordan; Kinnick; Lind; Morin Jr.; Noreen; Oberg; Palkowitz; Parrish; Pranc; Sahlberg; Ternansky; Vasileff; Vrang; West; et al.

Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4929 - 4936 Title/Abstract Full Text View citing articles Show Details

Biagi; Giorgi; Livi; Scartoni; Breschi; Martini; Scatizzi

Farmaco, 1995 , vol. 50, # 10 p. 659 - 667 Title/Abstract Full Text View citing articles Show Details

Isakovich, I. P.; Azimov, V. A.; Ryabova, S. Yu.; Alekseeva, L. M.; Parshin, V. P.; et al.

Pharmaceutical Chemistry Journal, 1995 , vol. 29, # 2 p. 100 - 105 Khimiko-Farmatsevticheskii Zhurnal, 1995 , vol. 29, # 2 p. 22 - 26 Title/Abstract Full Text Show Details

Micovic, Ivan V.; Ivanovic; Roglic, Goran M.; Kiricojevic, Vesna D.; Popovic, Jelena B.

Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 3 p. 265 - 269 Title/Abstract Full Text View citing articles Show Details

Grunewald, Gary L.; Dahanukar, Vilas H.; Ching, Piao; Criscione, Kevin R.

Journal of Medicinal Chemistry, 1996 , vol. 39, # 18 p. 3539 - 3546 Title/Abstract Full Text View citing articles Show Details

Kaufman, Melvin S.; Hatzis, Alexander C.; Stuart, John G.

Journal of Mass Spectrometry, 1996 , vol. 31, # 8 p. 913 - 920 Title/Abstract Full Text View citing articles Show Details

Omelanczuk, Jan; Mikolajczyk, Marian

Tetrahedron Asymmetry, 1996 , vol. 7, # 9 p. 2687 - 2694 Title/Abstract Full Text View citing articles Show Details

Sun; Bernstein

Journal of the American Chemical Society, 1996 , vol. 118, # 21 p. 5086 - 5095 Title/Abstract Full Text View citing articles Show Details

Biagi; Giorgi; Livi; Manera; Scartoni; Lucacchini; Senatore

Farmaco, 1996 , vol. 51, # 8-9 p. 601 - 608 Title/Abstract Full Text View citing articles Show Details

Riddell, Frank G.; Rogerson, Martin

Journal of the Chemical Society. Perkin Transactions 2, 1997 , # 2 p. 249 - 255 Title/Abstract Full Text View citing articles Show Details

Unterhalt; Bause

Pharmazie, 1997 , vol. 52, # 11 p. 878 - 878 Title/Abstract Full Text View citing articles Show Details

Mazurov, Anatoly A.; Andronati, Sergei A.; Korotenko, Tamara I.; Sokolenko, Nikolai I.; Dyadenko, Alexei I.; Shapiro, Yury E.; Gorbatyuk, Vitalii Ya.; Voronina, Tatyana A.

Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 11 p. 2029 - 2040


Title/Abstract Full Text View citing articles Show Details

Sparatore; Novelli

Farmaco, 1997 , vol. 52, # 8-9 p. 509 - 521 Title/Abstract Full Text View citing articles Show Details

25 of 317

26 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Nagasawa, Kazuo

Heterocycles, 1997 , vol. 45, # 6 p. 1047 - 1050 Title/Abstract Full Text View citing articles Show Details

Parker, Matthew A.; Marona-Lewicka, Danuta; Kurrasch, Deborah; Shulgin, Alexander T.; Nichols, David E.

Journal of Medicinal Chemistry, 1998 , vol. 41, # 6 p. 1001 - 1005 Title/Abstract Full Text View citing articles Show Details

Betti, Laura; Biagi, Giuliana; Giannaccini, Gino; Giorgi, Irene; Livi, Oreste; Lucacchini, Antonio; Manera, Clementina; Scartoni, Valerio

Journal of Medicinal Chemistry, 1998 , vol. 41, # 5 p. 668 - 673 Title/Abstract Full Text View citing articles Show Details

Thunhorst, Martin; Holzgrabe, Ulrike

Magnetic Resonance in Chemistry, 1998 , vol. 36, # 3 p. 211 - 216 Title/Abstract Full Text View citing articles Show Details

Estep, Kimberly G.; Neipp, Christopher E.; Stephens Stramiello, Linda M.; Adam, Mavis D.; Allen, Martin P.; Robinson, Shaughnessy; Roskamp, Eric J.

Journal of Organic Chemistry, 1998 , vol. 63, # 16 p. 5300 - 5301 Title/Abstract Full Text View citing articles Show Details

Pifl, Christian; Drobny, Helmut; Reither, Harald; Hornykiewicz, Oleh; Singer, Ernst A.

Molecular Pharmacology, 1995 , vol. 47, # 2 p. 368 - 373 Title/Abstract Full Text View citing articles Show Details

Kikura; Nakahara

Biological and Pharmaceutical Bulletin, 1995 , vol. 18, # 12 p. 1694 - 1699 Title/Abstract Full Text View citing articles Show Details

Wall, Stephen C.; Gu, Howard; Rudnick, Gary

Molecular Pharmacology, 1995 , vol. 47, # 3 p. 544 - 550 Title/Abstract Full Text View citing articles Show Details

Protais; Chagraoui; Arbaoui; Mocaer

European Journal of Pharmacology, 1994 , vol. 271, # 1 p. 167 - 177 Title/Abstract Full Text View citing articles Show Details

Seager

Journal of Pharmacy and Pharmacology, 1998 , vol. 50, # 4 p. 375 - 382 Title/Abstract Full Text View citing articles Show Details

Morozov; Klimova; Lavrova; Avdyunina; Pyatin; Troitskaya; Bykov

Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 1 p. 1 - 4 Title/Abstract Full Text View citing articles Show Details

Humphreys; Tanner

Human and Experimental Toxicology, 1994 , vol. 13, # 5 p. 311 - 312 Title/Abstract Full Text View citing articles Show Details

Cirimele; Kintz; Mangin

Archives of Toxicology, 1995 , vol. 70, # 1 p. 68 - 69 Title/Abstract Full Text View citing articles Show Details

Nakahara, Yuji; Kikura, Ruri

Archives of Toxicology, 1996 , vol. 70, # 12 p. 841 - 849 Title/Abstract Full Text View citing articles Show Details

Markaryan; Airapetyan; Mikaelyan; Asatryan; Noravyan

Pharmaceutical Chemistry Journal, 1997 , vol. 31, # 2 p. 71 - 73 Title/Abstract Full Text View citing articles Show Details

Gyenes, Ferenc; Bergmann, Kathryn E.; Welch, John T.

Journal of Organic Chemistry, 1998 , vol. 63, # 9 p. 2824 - 2828 Title/Abstract Full Text View citing articles Show Details

Avakyan; Vartanyan; Markaryan; Asatryan; Noravyan; Gevondyan

Pharmaceutical Chemistry Journal, 1997 , vol. 31, # 4 p. 178 - 181 Title/Abstract Full Text View citing articles Show Details

Nakahara; Takahashi; Kikura

Biological and Pharmaceutical Bulletin, 1995 , vol. 18, # 9 p. 1223 - 1227 Title/Abstract Full Text View citing articles Show Details

Sasaki; Shibata; Hashimoto; Iwasaki

Biological and Pharmaceutical Bulletin, 1995 , vol. 18, # 9 p. 1228 - 1233 Title/Abstract Full Text View citing articles Show Details

Maurel-Remy; Bervoets; Millan

European Journal of Pharmacology, 1995 , vol. 280, # 2 p. R9-R11 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

Bioactivities present

Reference

Banks; Gratton

European Journal of Pharmacology, 1995 , vol. 282, # 1-3 p. 157 - 167 Title/Abstract Full Text View citing articles Show Details

Schmidt; Sorensen; Kehne; Carr; Palfreyman

Life Sciences, 1995 , vol. 56, # 25 p. 2209 - 2222 Title/Abstract Full Text View citing articles Show Details

Chueh; Hsieh; Chen; Lin

Pharmacology, 1995 , vol. 51, # 4 p. 237 - 244 Title/Abstract Full Text View citing articles Show Details


Browman; Badiani; Robinson

Journal of Pharmacology and Experimental Therapeutics, 1998 , vol. 287, # 3 p. 1007 - 1014 Title/Abstract Full Text View citing articles Show Details

Pal, Siddhartha; Sen; Chaudhuri, A.K. Nag

Journal of Pharmacy and Pharmacology, 1999 , vol. 51, # 3 p. 313 - 318 Title/Abstract Full Text View citing articles Show Details

Tsai, Shiow-Chwen; Chiao, Yu-Chung; Lu, Chien-Chen; Doong, Ming-Luen; Chen, Yen-Hao; Shih, Hsi-Chang; Liaw, Charlie; Wang, Shyi-Wu; Wang, Paulus S.

British Journal of Pharmacology, 1996 , vol. 118, # 4 p. 984 - 988 Title/Abstract Full Text View citing articles Show Details

Borel; Abbott

Chemical Research in Toxicology, 1995 , vol. 8, # 6 p. 891 - 899 Title/Abstract Full Text View citing articles Show Details

Betti, Laura; Biagi, Giuliana; Giannaccini, Gino; Giorgi, Irene; Livi, Oreste; Lucacchini, Antonio; Manera, Clementina; Scartoni, Valerio

European Journal of Medicinal Chemistry, 1999 , vol. 34, # 10 p. 867 - 875 Title/Abstract Full Text View citing articles Show Details

Bach, Mimi V.; Coutts; Baker

Xenobiotica, 1999 , vol. 29, # 7 p. 719 - 732 Title/Abstract Full Text View citing articles Show Details

Bach; Coutts; Baker

Xenobiotica, 2000 , vol. 30, # 3 p. 297 - 306 Title/Abstract Full Text View citing articles Show Details

Biagi, Giuliana; Giorgi, Irene; Livi, Oreste; Manera, Clementina; Scartoni, Valerio; Betti, Laura; Giannaccini, Gino; Lucacchini, Antonio

Farmaco, 1999 , vol. 54, # 9 p. 615 - 623 Title/Abstract Full Text View citing articles Show Details

Hartung, Christian G.; Breindl, Claudia; Tillack, Annegret; Beller, Matthias

Tetrahedron, 2000 , vol. 56, # 29 p. 5157 - 5162 Title/Abstract Full Text View citing articles Show Details

Subramanyam

Tetrahedron Letters, 2000 , vol. 41, # 34 p. 6537 - 6540 Title/Abstract Full Text View citing articles Show Details

Eshleman; Neve; Janowsky

Journal of Pharmacology and Experimental Therapeutics, 1995 , vol. 274, # 1 p. 276 - 283 Title/Abstract Full Text View citing articles Show Details

Wang; Johnson

Journal of Pharmacology and Experimental Therapeutics, 1995 , vol. 275, # 2 p. 877 - 884 Title/Abstract Full Text View citing articles Show Details

Kinbara, Kazushi; Harada, Yoshiko; Saigo, Kazuhiko

Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 7 p. 1339 - 1347 Title/Abstract Full Text View citing articles Show Details

Haak, Edgar; Siebeneicher, Holger; Doye, Sven

Organic Letters, 2000 , vol. 2, # 13 p. 1935 - 1937 Title/Abstract Full Text View citing articles Show Details

Blasco-Gomez; Bosch-Reig; Campins-Falco; Molins-Legua; Herraez-Hernandez

Analytical Chemistry, 2000 , vol. 72, # 11 p. 2559 - 2565 Title/Abstract Full Text View citing articles Show Details

Avakyan; Vartanyan; Markaryan; Asatryan; Noravyan

Pharmaceutical Chemistry Journal, 1999 , vol. 33, # 10 p. 528 - 530 Title/Abstract Full Text View citing articles Show Details

Ferrarini, Pier Luigi; Mori, Claudio; Badawneh, Muwaffag; Calderone, Vincenzo; Greco, Rosamiria; Manera, Clementina; Martinelli, Adriano; Nieri, Paola; Saccomanni, Giuseppe

European Journal of Medicinal Chemistry, 2000 , vol. 35, # 9 p. 815 - 826 Title/Abstract Full Text View citing articles Show Details

27 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Yu, Han; Rothman, Richard B; Dersch, Christina M; Partilla, John S; Rice, Kenner C

Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 12 p. 2689 - 2692 Title/Abstract Full Text View citing articles Show Details

Dowd; Herrick-Davis; Egan; DuPre; Smith; Teitler; Glennon

Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 3074 - 3084 Title/Abstract Full Text View citing articles Show Details

Zurita, Alejandra; Muru, Sergio; Molina, Victor

European Journal of Pharmacology, 1996 , vol. 299, # 1-3 p. 1 - 7 Title/Abstract Full Text View citing articles Show Details

Eblen, Frank; Loeschmann, Peter-Andreas; Wuellner, Ullrich; Turski, Lechoslaw; Klockgether, Thomas

European Journal of Pharmacology, 1996 , vol. 299, # 1-3 p. 9 - 16 Title/Abstract Full Text View citing articles Show Details

Sills, Terrence L.; Crawley, Jacqueline N.

European Journal of Pharmacology, 1996 , vol. 303, # 3 p. 177 - 181 Title/Abstract Full Text View citing articles Show Details

Maes, J. H. Roald; Van Rijn, Clementina M.; Vossen, Jo M. H.

European Journal of Pharmacology, 1996 , vol. 309, # 2 p. 131 - 140 Title/Abstract Full Text View citing articles Show Details

Bansal, Ekta; Srivastava; Kumar, Ashok

European Journal of Medicinal Chemistry, 2001 , vol. 36, # 1 p. 81 - 92 Title/Abstract Full Text View citing articles Show Details

Yoneda, Fumio; Moto, Toshiaki; Sakae, Masatoshi; Ohde, Hironori; Knoll, Berta; Miklya, Ildiko; Knoll, Joseph

Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 5 p. 1197 - 1212 Title/Abstract Full Text View citing articles Show Details

Davis; Durden

Synthetic Communications, 2001 , vol. 31, # 4 p. 569 - 578


Title/Abstract Full Text View citing articles Show Details

Bahajaj; Vernon; Wilson

Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 12 p. 1446 - 1451 Title/Abstract Full Text View citing articles Show Details

Olds, Marianne E.

European Journal of Pharmacology, 1996 , vol. 306, # 1-3 p. 23 - 32 Title/Abstract Full Text View citing articles Show Details

Segal, David S.; Kuczenski, Ronald

Journal of Pharmacology and Experimental Therapeutics, 1999 , vol. 291, # 1 p. 19 - 30 Title/Abstract Full Text View citing articles Show Details

Devoto, Paola; Flore, Giovanna; Ibba, Antonio; Fratta, Walter; Pani, Luca

Toxicology Letters, 2001 , vol. 121, # 3 p. 199 - 206 Title/Abstract Full Text View citing articles Show Details

Sekine, Hitoshi; Nagao, Shigeyuki; Nakahara, Yuji

Biological and Pharmaceutical Bulletin, 1996 , vol. 19, # 6 p. 845 - 851 Title/Abstract Full Text View citing articles Show Details

Clement; Behrens; Moller; Cashman

Chemical Research in Toxicology, 2000 , vol. 13, # 10 p. 1037 - 1045 Title/Abstract Full Text View citing articles Show Details

Lapeyre-Mestre; Damase-Michel; Adams; Michaud; Montastruc

European Journal of Clinical Pharmacology, 1997 , vol. 52, # 1 p. 37 - 39 Title/Abstract Full Text View citing articles Show Details

Dierickx, Paul J.; Scheers, Ellen M.

Journal of Applied Toxicology, 2002 , vol. 22, # 1 p. 61 - 65 Title/Abstract Full Text View citing articles Show Details

Chang; Pan; Lin

British Journal of Pharmacology, 2001 , vol. 132, # 7 p. 1524 - 1530 Title/Abstract Full Text View citing articles Show Details

Janin, Yves L.; Roulland, Emmanuel; Beurdeley-Thomas, Arnaud; Decaudin, Didier; Monneret, Claude; Poupon, MarieFrance

Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 4 p. 529 - 532 Title/Abstract Full Text View citing articles Show Details

Biagi, Giuliana; Giorgi, Irene; Livi, Oreste; Scartoni, Valerio; Betti, Laura; Giannaccini, Gino; Trincavelli, Maria Letizia

European Journal of Medicinal Chemistry, 2002 , vol. 37, # 7 p. 565 - 571 Title/Abstract Full Text View citing articles Show Details

28 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Abraham, Michael H; Zhao, Yuan H; Le, Joelle; Hersey, Anne; Luscombe, Christopher N; Reynolds, Derek P; Beck, Gordon; Sherborne, Brad; Cooper, Ian

European journal of medicinal chemistry, 2002 , vol. 37, # 7 p. 595 - 605 Title/Abstract Full Text View citing articles Show Details

Gonzalez-Sabin, Javier; Gotor, Vicente; Rebolledo, Francisca

Tetrahedron Asymmetry, 2002 , vol. 13, # 12 p. 1315 - 1320 Title/Abstract Full Text View citing articles Show Details

Pallavicini, Marco; Bolchi, Cristiano; Fumagalli, Laura; Valoti, Ermanno; Villa, Luigi

Tetrahedron Asymmetry, 2002 , vol. 13, # 20 p. 2277 - 2282 Title/Abstract Full Text View citing articles Show Details

Viswanathan, Rajesh; Prabhakaran, Erode N.; Plotkin, Michael A.; Johnston, Jeffrey N.

Journal of the American Chemical Society, 2003 , vol. 125, # 1 p. 163 - 168 Title/Abstract Full Text View citing articles Show Details

Li, Yanjun; Izumi, Taeko

Journal of the Chinese Chemical Society (Taipei, Taiwan), 2002 , vol. 49, # 4 p. 505 - 508 Title/Abstract Full Text View citing articles Show Details

Hedou, Gael; Homberg, Judith; Martin, Sonsoles; Wirth, Katja; Feldon, Joram; Heidbreder, Christian A.

European Journal of Pharmacology, 2000 , vol. 390, # 1-2 p. 127 - 136 Title/Abstract Full Text View citing articles Show Details

Nagy, Peter I.; Alagona, Giuliano; Ghio, Caterina; Takacs-Novak, Krisztina

Journal of the American Chemical Society, 2003 , vol. 125, # 9 p. 2770 - 2785 Title/Abstract Full Text View citing articles Show Details

Hadzic, Pavle; Vukojevic, Nada

Carbohydrate Research, 2003 , vol. 338, # 11 p. 1243 - 1249 Title/Abstract Full Text View citing articles Show Details

Sun; Ginovart; Ko; Seeman; Kapur

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Li, Yanjun; Izumi, Taeko

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Comment (Pharmacological Data)

Bioactivities present

Reference

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Daly; Creveling; Witkop

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Bioactivities present

Reference

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Comment (Pharmacological Data)

Bioactivities present

Reference

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Journal of medicinal chemistry, 1986 , vol. 29, # 2 p. 194 - 199 Title/Abstract Full Text Show Details

Rafferty; Wilson; Monn; Krass; Borchardt; Grunewald

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European Journal of Pharmacology, 1980 , vol. 68, # 3 p. 395 - 396 Title/Abstract Full Text Show Details

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Journal of Medicinal Chemistry, 1973 , vol. 16, # 12 p. 1394 - 1396 Title/Abstract Full Text Show Details

Hansch; Glave

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Comment (Pharmacological Data)

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Reference

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Comment (Pharmacological Data)

Bioactivities present

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Frank P. Palopoli

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OZAKI; WEISSBACH; WITKOP; UDENFRIEND

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NOT AVAILABLE

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Famiglini, Valeria; La Regina, Giuseppe; Coluccia, Antonio; Pelliccia, Sveva; Brancale, Andrea; Maga, Giovanni; Crespan, Emmanuele; Badia, Roger; Clotet, Bonaventura; Esté, José A.; Cirilli, Roberto; Novellino, Ettore; Silvestri, Romano

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Chu, Shu-Chen; Chen, Pei-Ni; Hsieh, Yih-Shou; Yu, Ching-Han; Lin, Meng-Hsuan; Lin, Yan-Han; Kuo, Dong-Yih

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Comment (Pharmacological Data)

Bioactivities present

Reference

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JANSSEN PHARMACEUTICA NV; DVORAK, Curt A.; LIU, Changlu; KUEI, Chester

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Lin, Huei-Ru; Liao, Chao-Chuan; Lin, Tzu-Chieh

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PHILADELPHIA HEALTH AND EDUCATION CORPORATION D/B/A DREXEL UNIVERSITY COLLEGE OF MEDICINE; KORTAGERE, Sandhya; MORTENSEN, Ole Valente; MORTENSEN, Andreia C.K.

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Alvaro, Giuseppe; Marasco, Agostino

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Bubser, Michael; Bridges, Thomas M.; Dencker, Ditte; Gould, Robert W.; Grannan, Michael; Noetzel, Meredith J.; Lamsal, Atin; Niswender, Colleen M.; Daniels, J. Scott; Poslusney, Michael S.; Melancon, Bruce J.; Tarr, James C.; Byers, Frank W.; Wess, Jürgen; Duggan, Mark E.; Dunlop, John; Wood, Michael W.; Brandon, Nicholas J.; Wood, Michael R.; Lindsley, Craig W.; Conn, P. Jeffrey; Jones, Carrie K.

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Stoykov, Mary Ellen; Madhavan, Sangeetha

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Persona, Karolina; Madej, Katarzyna; Knihnicki, Paweł; Piekoszewski, Wojciech

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Edemann-Callesen, Henriette; Voget, Mareike; Empl, Laura; Vogel, Martin; Wieske, Franziska; Rummel, Julia; Heinz, Andreas; Mathé, Aleksander A.; Hadar, Ravit; Winter, Christine

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Comment (Pharmacological Data)

Bioactivities present

Reference

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Oswald, Lynn M.; Wand, Gary S.; Wong, Dean F.; Brown, Clayton H.; Kuwabara, Hiroto; Brašić, James R.

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Polak, Piotr; Michalak, Agnieszka; Biała, Grażyna; Kruk-Słomka, Marta; Budzyńska, Barbara

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Authier, Simon; Bassett, Leanne; Pouliot, Mylene; Rachalski, Adeline; Troncy, Eric; Paquette, Dominique; Mongrain, Valérie

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Trujols, Joan; Vasconcelos e Rego, Lisiane; Iraurgi, Ioseba; Batlle, Francesca; Pérez de los Cobos, José; Siñol, Núria

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David, Hélène N.; Dhilly, Martine; Poisnel, Géraldine; Degoulet, Mickael; Meckler, Cédric; Vallée, Nicolas; Blatteau, JeanÉric; Risso, Jean-Jacques; Lemaire, Marc; Debruyne, Danièle; Abraini, Jacques H.

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Piotrowski, Przemysław; Bocian, Szymon; ͆liwka, Karol; Buszewski, Bogusław

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Madularu, Dan; Yee, Jason R.; Kenkel, William M.; Moore, Kelsey A.; Kulkarni, Praveen; Shams, Waqqas M.; Ferris, Craig F.; Brake, Wayne G.

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Molero-Chamizo, Andrés

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Comment (Pharmacological Data)

Bioactivities present

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Comment (Pharmacological Data)

Bioactivities present

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Comment

Bioactivities present


(Pharmacological Data) Reference

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Comment (Pharmacological Data)

Bioactivities present

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Comment (Pharmacological Data)

Bioactivities present

Reference

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Glat, Micaela Johanna; Ben-Zur, Tali; Barhum, Yael; Offen, Daniel

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Comment (Pharmacological Data)

Bioactivities present

Reference

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Moraes, Livia S.; Rohor, Bruna Z.; Areal, Lorena B.; Pereira, Evaldo V.; Santos, Alexandre M.C.; Facundo, Valdir A.; Santos, Adair R.S.; Pires, Rita G.W.; Martins-Silva, Cristina

Journal of Ethnopharmacology, 2016 , vol. 185, p. 68 - 76 Title/Abstract Full Text View citing articles Show Details

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Bonito-Oliva, Alessandra; Södersten, Erik; Spigolon, Giada; Hu, Xiaochen; Hellysaz, Arash; Falconi, Anastasia; Gomes, AnaLuisa; Broberger, Christian; Hansen, Klaus; Fisone, Gilberto

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Pitchers; Di Sebastiano; Coolen

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Title/Abstract Full Text View citing articles Show Details

Toledano, Daniel; Gisquet-Verrier, Pascale

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Behavioural Brain Research, 2016 , vol. 307, p. 35 - 45 Title/Abstract Full Text View citing articles Show Details

RUGEN HOLDINGS (CAYMAN) LIMITED; SHAPIRO, Gideon

Patent: WO2016/44323 A1, 2016 ; Title/Abstract Full Text Show Details

Jankowski, Wojciech; Hoffmann, Marcin

Journal of Medical Internet Research, 2016 , vol. 18, # 2 art. no. E38 Title/Abstract Full Text View citing articles Show Details

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Comment (Pharmacological Data)

Bioactivities present

Reference

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Grabrucker, Andreas M; Ruozi, Barbara; Belletti, Daniela; Pederzoli, Francesca; Forni, Flavio; Vandelli, Maria Angela; Tosi, Giovanni

Tissue Barriers, 2016 , vol. 4, # 1 p. 18 Title/Abstract Full Text View citing articles Show Details

Schumacher, Anett; Sivanandan, Brindan; Tolledo, Edgor Cole; Woldegabriel, Jacob; Ito, Rutsuko

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Kannan, Geetha; Crawford, Joshua A.; Yang, ChunXia; Gressitt, Kristin L.; Ihenatu, Chinezimuzo; Krasnova, Irina N.; Cadet, Jean Lud; Yolken, Robert H.; Severance, Emily G.; Pletnikov, Mikhail V.

Neurobiology of Disease, 2016 , vol. 91, p. 307 - 314 Title/Abstract Full Text View citing articles Show Details

Steger, Julia; Arnhard, Kathrin; Haslacher, Sandra; Geiger, Klemens; Singer, Klaus; Schlapp, Michael; Pitterl, Florian; Oberacher, Herbert

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Branch, Sarah Y.; Chen, Cang; Sharma, Ramaswamy; Lechleiter, James D.; Li, Senlin; Beckstead, Michael J.

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Sampat, Andjoe; Lopatka, Martin; Sjerps, Marjan; Vivo-Truyols, Gabriel; Schoenmakers, Peter; van Asten, Arian

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Hartung, Benno; Schwender, Holger; Roth, Eckhard H.; Hellen, Florence; Mindiashvili, Nona; Rickert, Annette; Ritz-Timme, Stefanie; Grieser, Almut; Monticelli, Fabio; Daldrup, Thomas

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Cappelletti, Simone; Piacentino, Daria; Sani, Gabriele; Bottoni, Edoardo; Fiore, Paola Antonella; Aromatario, Mariarosaria; Ciallella, Costantino

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Homberg, Judith R.; Kyzar, Evan J.; Nguyen, Michael; Norton, William H.; Pittman, Julian; Poudel, Manoj K.; Gaikwad, Siddharth; Nakamura, Shun; Koshiba, Mamiko; Yamanouchi, Hideo; Scattoni, Maria Luisa; Ullman, Jeremy F.P.; Diamond, David M.; Kaluyeva, Aleksandra A.; Parker, Matthew O.; Klimenko, Victor M.; Apryatin, Sergey A.; Brown, Richard E.; Song, Cai; Gainetdinov, Raul R.; Gottesman, Irving I.; Kalueff, Allan V.

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Santos-Toscano, Raquel; Borcel, Érika; Ucha, Marcos; Orihuel, Javier; Capellán, Roberto; Roura-Martínez, David; Ambrosio, Emilio; Higuera-Matas, Alejandro

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Lee, Hei-Hwa; Lee, Jong-Feng; Lin, Shin-Yu; Chen, Bai-Hsiun

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Macúchová; Ševčíková; Hrebíčková; Nohejlová; Šlamberová

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Comment (Pharmacological Data)

Bioactivities present

Reference

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Zhang, Kai; Zhao, Yan; Wang, Qingzhong; Jiang, Haifeng; Du, Jiang; Yu, Shunying; Zhao, Min

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Argente-García; Moliner-Martínez; Campíns-Falcó; Verdú-Andrés; Herráez-Hernández

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Rodayan, Angela; Afana, Shadi; Segura, Pedro A.; Sultana, Tamanna; Metcalfe, Chris D.; Yargeau, Viviane

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Odiba, Arome; Ukegbu, Chimere; Anunobi, Oluchukwu; Chukwunonyelum, Ike; Esemonu, Juliet

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Proceedings of the National Academy of Sciences of the United States of America, 2016 , vol. 113, # 17 p. E2440 - E2449 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

Bioactivities present

Reference

Di Rago, Matthew; Chu, Mark; Rodda, Luke N; Jenkins, Elizabeth; Kotsos, Alex; Gerostamoulos, Dimitri

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Isingrini, Elsa; Perret, Lea; Rainer, Quentin; Sagueby, Sara; Moquin, Luc; Gratton, Alain; Giros, Bruno

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Farnia, Vahid; Shakeri, Jalal; Tatari, Faezeh; Juibari, Toraj Ahmadi; Bajoghli, Hafez; Golshani, Senoobar; Hookari, Sara; Holsboer-Trachsler, Edith; Brand, Serge

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ACS Chemical Biology, 2016 , vol. 11, # 4 p. 842 - 849 Title/Abstract Full Text View citing articles Show Details

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International Journal of Neuropsychopharmacology, 2016 , vol. 19, # 4 art. no. PYV116 Title/Abstract Full Text View citing articles Show Details

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Brain, 2016 , vol. 139, # 5 p. 1325 - 1347 Title/Abstract Full Text View citing articles Show Details

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Comment (Pharmacological Data)

Bioactivities present

Reference

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Comment (Pharmacological Data)

Bioactivities present

Reference

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Li, Qi; Chan, Siu Yuen; Wong, Kwun K.; Wei, Ran; Leung, Yu On; Ding, Abby Y.; Hui, Tomy C. K.; Cheung, Charlton; Chua, Siew E.; Sham, Pak C.; Wu, Ed X.; McAlonan, Grainne M.

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Vuorenpää, Anne; Jørgensen, Trine N.; Newman, Amy H.; Madsen, Kenneth L.; Scheinin, Mika; Gether, Ulrik

Journal of Biological Chemistry, 2016 , vol. 291, # 11 p. 5634 - 5651


Title/Abstract Full Text View citing articles Show Details

Lieberwirth, Claudia; Wang, Zuoxin

Current Opinion in Neurobiology, 2016 , vol. 40, p. 8 - 13 Title/Abstract Full Text View citing articles Show Details

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Forensic Science International, 2016 , vol. 266, p. 170 - 177 Title/Abstract Full Text View citing articles Show Details

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Behavioural Brain Research, 2016 , vol. 311, p. 322 - 329 Title/Abstract Full Text View citing articles Show Details

Al Shehri, Mohammed A.; Youssef, Ali A.

Journal of the Saudi Heart Association, 2016 , vol. 28, # 3 p. 180 - 184 Title/Abstract Full Text View citing articles Show Details

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Journal of the Brazilian Chemical Society, 2016 , vol. 27, # 6 p. 992 - 997 Title/Abstract Full Text View citing articles Show Details

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Comment (Pharmacological Data)

Bioactivities present

Reference

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Neuroscience, 2016 , vol. 330, p. 162 - 170 Title/Abstract Full Text View citing articles Show Details

Vieira, Simone M.; Michels, Luana R.; Roversi, Katiane; Metz, Vinícia G.; Moraes, Barbra K.S.; Piegas, Eduarda M.; Freddo, Rodrigo J.; Gundel, André; Costa, Teresa Dalla; Burger, Marilise E.; Colomé, Letícia M.; Haas, Sandra E.

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Drogies; Willenberg; Ramshorn-Zimmer; Weidhase; Petros; Hädrich; Thiery; Gries; Bernhard

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H. LUNDBECK A/S; LARSEN, Lone Frydelund; AREBERG, Johan; BREYSSE, Nathalie; CHANDRASENA, Gamini

Patent: WO2016/87429 A1, 2016 ; Title/Abstract Full Text Show Details

Zeeb, Fiona D.; Soko, Ashlie D.; Ji, Xiaodong; Fletcher, Paul J.

Neuropsychopharmacology, 2016 , vol. 41, # 8 p. 2091 - 2100 Title/Abstract Full Text View citing articles Show Details

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Journal of Substance Use, 2016 , vol. 21, # 3 p. 327 - 330 Title/Abstract Full Text View citing articles Show Details

Lazenka, Matthew F.; Legakis, Luke P.; Stevens Negus

Experimental and Clinical Psychopharmacology, 2016 , vol. 24, # 3 p. 193 - 205 Title/Abstract Full Text View citing articles Show Details

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European Neuropsychopharmacology, 2016 , vol. 26, # 6 p. 901 - 922 Title/Abstract Full Text View citing articles Show Details

Valle, Marta; Maqueda, Ana Elda; Rabella, Mireia; Rodríguez-Pujadas, Aina; Antonijoan, Rosa Maria; Romero, Sergio; Alonso, Joan Francesc; Mañanas, Miquel Àngel; Barker, Steven; Friedlander, Pablo; Feilding, Amanda; Riba, Jordi

European Neuropsychopharmacology, 2016 , vol. 26, # 7 p. 1161 - 1175 Title/Abstract Full Text View citing articles Show Details

Bisagno, Veronica; González, Betina; Urbano, Francisco J.

Pharmacological Research, 2016 , vol. 109, p. 108 - 118 Title/Abstract Full Text View citing articles Show Details

Kambeitz, Joseph; la Fougère, Christian; Werner, Natalie; Pogarell, Oliver; Riedel, Michael; Falkai, Peter; Ettinger, Ulrich

European Neuropsychopharmacology, 2016 , vol. 26, # 6 p. 938 - 947 Title/Abstract Full Text View citing articles Show Details

Shariatgorji, Mohammadreza; Strittmatter, Nicole; Nilsson, Anna; Källback, Patrik; Alvarsson, Alexandra; Zhang, Xiaoqun; Vallianatou, Theodosia; Svenningsson, Per; Goodwin, Richard J.A.; Andren, Per E.

NeuroImage, 2016 , vol. 136, p. 129 - 138 Title/Abstract Full Text View citing articles Show Details

Butini; Nikolic; Kassel; Brückmann; Filipic; Agbaba; Gemma; Brogi; Brindisi; Campiani; Stark

Progress in Neurobiology, 2016 , vol. 142, p. 68 - 103 Title/Abstract Full Text View citing articles Show Details

Rapanelli, Maximiliano; Pittenger, Christopher

Neuropharmacology, 2016 , vol. 106, p. 85 - 90 Title/Abstract Full Text View citing articles Show Details

Grechnikov; Borodkov; Alimpiev; Nikiforov; Simanovskii, Ya. O.; Karavanskii

Journal of Analytical Chemistry, 2010 , vol. 65, # 14 p. 1504 - 1510 Title/Abstract Full Text View citing articles Show Details

Zestos, Alexander G.; Mikelman, Sarah R.; Kennedy, Robert T.; Gnegy, Margaret E.

ACS Chemical Neuroscience, 2016 , vol. 7, # 6 p. 757 - 766 Title/Abstract Full Text View citing articles Show Details

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Journal of Pediatrics, 2016 , vol. 170, p. 34,38e1 Title/Abstract Full Text View citing articles Show Details

Singer, Bryan F.; Bubula, Nancy; Li, Dongdong; Przybycien-Szymanska, Magdalena M.; Bindokas, Vytautas P.; Vezina, Paul

Neuropsychopharmacology, 2016 , vol. 41, # 8 p. 2178 - 2187


Title/Abstract Full Text View citing articles Show Details

El-Sayed El-Sisi, Alaa; Sokkar, Samia Salem; El-Sayed El-Sayad, Magda; Sayed Ramadan, Ehab; Osman, Enass Yossef

Biomedicine and Pharmacotherapy, 2016 , vol. 82, p. 425 - 431 Title/Abstract Full Text View citing articles Show Details

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59 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Matsui; Matsunaga; Matsuda; Kishi; Iwata

Pharmacopsychiatry, 2016 , vol. 49, # 3 p. 97 - 106 Title/Abstract Full Text View citing articles Show Details

Sharifi, Vahid; Abbasi, Ali; Nosrati, Anahita

Journal of Food and Drug Analysis, 2016 , vol. 24, # 2 p. 264 - 276 Title/Abstract Full Text View citing articles Show Details

Draughon Moret, Jessica E.; Carrico, Adam W.; Evans, Jennifer L.; Stein, Ellen S.; Couture, Marie-Claude; Maher, Lisa; Page, Kimberly

Drug and Alcohol Dependence, 2016 , vol. 161, p. 171 - 177 Title/Abstract Full Text View citing articles Show Details

Hail-Jares, Katie; Choi, Sugy; Duo, Lin; Luo, Zhi; Huang, Z. Jennifer

Drug and Alcohol Dependence, 2016 , vol. 161, p. 42 - 49 Title/Abstract Full Text View citing articles Show Details

Gilder, David A.; Stouffer, Gina M.; Lau, Philip; Ehlers, Cindy L.

Drug and Alcohol Dependence, 2016 , vol. 161, p. 222 - 229 Title/Abstract Full Text View citing articles Show Details

Been, Frederic; Bijlsma, Lubertus; Benaglia, Lisa; Berset, Jean-Daniel; Botero-Coy, Ana M.; Castiglioni, Sara; Kraus, Ludwig; Zobel, Frank; Schaub, Michael P.; Bücheli, Alexander; Hernández, Félix; Delémont, Olivier; Esseiva, Pierre; Ort, Christoph

Drug and Alcohol Dependence, 2016 , vol. 161, p. 189 - 199 Title/Abstract Full Text View citing articles Show Details

Ahn, Woo-Young; Vassileva, Jasmin

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Neuroscience and Biobehavioral Reviews, 2016 , vol. 68, p. 370 - 386 Title/Abstract Full Text View citing articles Show Details

Chen, Mei-Fang; Lai, Su-Yu; Kung, Po-Cheng; Lin, Yo-Cheng; Yang, Hui-I.; Chen, Po-Yi; Liu, Ingrid Y.; Lua, Ahai Chang; Lee, Tony Jer-Fu

Toxicology and Applied Pharmacology, 2016 , vol. 305, p. 75 - 82 Title/Abstract Full Text View citing articles Show Details

Schenk, Susan; Foote, Jason; Aronsen, Dane; Bukholt, Natasha; Highgate, Quenten; Van De Wetering, Ross; Webster, Jeremy

Pharmacology Biochemistry and Behavior, 2016 , vol. 148, p. 38 - 45 Title/Abstract Full Text View citing articles Show Details

International Journal of Toxicology, 2008 , vol. 27, p. 107 - 138 Title/Abstract Full Text View citing articles Show Details

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International Journal of PharmTech Research, 2016 , vol. 9, # 5 p. 366 - 372 Title/Abstract Full Text View citing articles Show Details

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Yoon, Hyung Shin; Cai, Wen Ting; Lee, Young Hun; Park, Kyung Tae; Lee, Yong Sup; Kim, Jeong-Hoon

Behavioural Brain Research, 2016 , vol. 311, p. 403 - 407 Title/Abstract Full Text View citing articles Show Details

Damon, Deidre E.; Maher, Yosef S.; Yin, Mengzhen; Jjunju, Fred P. M.; Young, Iain S.; Taylor, Stephen; Maher, Simon; BaduTawiah, Abraham K.

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Minařík, Jakub; Gabrhelík, Roman; Malcolm, Robert; Pavlovská, Amalie; Miller, Peter

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Shekari, Ahmad; Akhgari, Maryam; Jokar, Farzaneh; Mousavi, Zahra

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Quesada, Loreto; Gomila, Isabel; Yates, Christopher; Barcelo, Catalina; Puiguriguer, Jordi; Barcelo, Bernardino

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Schrantee, Anouk; Ferguson, Bart; Stoffers, Diederick; Booij, Jan; Rombouts, Serge; Reneman, Liesbeth

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Bruckers, Liesbeth; Molenberghs, Geert; Drinkenburg, Pim; Geys, Helena

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Comment (Pharmacological Data)

Bioactivities present

Reference

Petersson, Frida J. M.; Tikkanen, Ronny; Schmidt, Axel J.

Substance Use and Misuse, 2016 , vol. 51, # 9 p. 1093 - 1103 Title/Abstract Full Text View citing articles Show Details

Hoffman, Alexander F.; Spivak, Charles E.; Lupica, Carl R.

ACS Chemical Neuroscience, 2016 , vol. 7, # 6 p. 700 - 709 Title/Abstract Full Text View citing articles Show Details

Schippers; Schetters; De Vries; Pattij

Psychopharmacology, 2016 , vol. 233, # 14 p. 2775 - 2785


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Shu, Irene; Alexander, Amy; Jones, Mary; Jones, Joseph; Negrusz, Adam

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2016 , vol. 1028, p. 145 - 152 Title/Abstract Full Text View citing articles Show Details

Fordahl, Steve C.; Locke, Jason L.; Jones, Sara R.

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Childs, Emma; Bershad, Anya K.; De Wit, Harriet

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Gregg, Ryan A.; Hicks, Callum; Nayak, Sunil U.; Tallarida, Christopher S.; Nucero, Paul; Smith, Garry R.; Reitz, Allen B.; Rawls, Scott M.

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Rennekamp, Andrew J.; Huang, Xi-Ping; Wang, You; Patel, Samir; Lorello, Paul J.; Cade, Lindsay; Gonzales, Andrew P. W.; Yeh, Jing-Ruey Joanna; Caldarone, Barbara J.; Roth, Bryan L.; Kokel, David; Peterson, Randall T.

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Solas, Maite; Milagro, Fermin I.; Martínez-Urbistondo, Diego; Ramirez, Maria J.; Martínez, J. Alfredo

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King, Christopher P.; Palmer, Abraham A.; Woods, Leah C. Solberg; Hawk, Larry W.; Richards, Jerry B.; Meyer, Paul J.

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Hamed, Adam; Daszczuk, Patrycja; Kursa, Miron Bartosz; Turzyńska, Danuta; Sobolewska, Alicja; Lehner, Małgorzata; Boguszewski, Paweł M.; Szyndler, Janusz

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Aljuffali, Ibrahim A.; Lin, Chwan-Fwu; Chen, Chun-Han; Fang, Jia-You

Expert Opinion on Drug Delivery, 2016 , vol. 13, # 9 p. 1311 - 1325 Title/Abstract Full Text View citing articles Show Details

Al-Serori, Halh; Ferk, Franziska; Angerer, Verena; Mišík, Miroslav; Nersesyan, Armen; Setayesh, Tahereh; Auwärter, Volker; Haslinger, Elisabeth; Huber, Wolfgang; Knasmüller, Siegfried

Toxicology Research, 2016 , vol. 5, # 5 p. 1410 - 1420 Title/Abstract Full Text View citing articles Show Details

Beharry, Shruti; Gibbons, Simon

Forensic Science International, 2016 , vol. 267, p. 25 - 34 Title/Abstract Full Text Show Details

Mackuľak, Tomáš; Bodík, Igor; Hasan, Jamal; Grabic, Roman; Golovko, Oksana; Vojs-Staňová, Andrea; Gál, Miroslav; Naumowicz, Monika; Tichý, Jozef; Brandeburová, Paula; Híveš, Ján

Forensic Science International, 2016 , vol. 267, p. 42 - 51 Title/Abstract Full Text Show Details

Steuer, Andrea E.; Eisenbeiss, Lisa; Kraemer, Thomas

Forensic Science International, 2016 , vol. 267, p. 52 - 59 Title/Abstract Full Text Show Details

Chung, Amanda S. J.; Cheng, Janice N. C.; Tse, Vincent

Current Bladder Dysfunction Reports, 2016 , vol. 11, # 3 p. 258 - 265 Title/Abstract Full Text Show Details

Huang, Jia; Yang, Xin-Hua; Lan, Yong; Zhu, Cui-Ying; Liu, Xiao-Qun; Wang, Ye-Fei; Cheung, Eric F.C.; Xie, Guang-Rong; Chan, Raymond C.K.

Neuropsychology, 2016 , vol. 30, # 6 p. 685 - 696 Title/Abstract Full Text Show Details

Bjarnadottir, Gudrun D.; Magnusson, Andres; Rafnar, Bjarni O.; Sigurdsson, Engilbert; Steingrimsson, Steinn; Johannsson, Magnus; Bragadottir, Helena; Haraldsson, H. Magnus

European Addiction Research, 2016 , vol. 22, # 5 p. 259 - 267 Title/Abstract Full Text Show Details

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Comment (Pharmacological Data)

Bioactivities present

Reference

Finnema, Sjoerd J.; Hughes, Zoë A.; Haaparanta-Solin, Merja; Stepanov, Vladimir; Nakao, Ryuji; Varnäs, Katarina; Varrone, Andrea; Arponen, Eveliina; Marjamäki, Päivi; Pohjanoksa, Katariina; Vuorilehto, Lauri; Babalola, Phebian A.; Solin, Olof; Grimwood, Sarah; Sallinen, Jukka; Farde, Lars; Scheinin, Mika; Halldin, Christer

International Journal of Neuropsychopharmacology, 2015 , vol. 18, # 3 Title/Abstract Full Text Show Details

Roschlau, Corinna; Votteler, Angeline; Hauber, Wolfgang

Learning and Memory, 2016 , vol. 23, # 8 p. 422 - 426 Title/Abstract Full Text Show Details

Amariles, Pedro; Cifuentes, Laura

Current Clinical Pharmacology, 2016 , vol. 11, # 2 p. 95 - 109 Title/Abstract Full Text Show Details

Yang, Zhen; Kelly, Clare; Castellanos, Francisco X.; Leon, Terry; Milham, Michael P.; Adler, Lenard A.

Journal of Child and Adolescent Psychopharmacology, 2016 , vol. 26, # 6 p. 527 - 536 Title/Abstract Full Text Show Details

Klein, Tracy A.; Panther, Shannon; Woo, Teri; Odom-Maryon, Tamara; Daratha, Kenn

Journal of Child and Adolescent Psychopharmacology, 2016 , vol. 26, # 6 p. 548 - 554 Title/Abstract Full Text Show Details

Haleem, Darakhshan Jabeen

Current Drug Targets, 2016 , vol. 17, # 11 p. 1282 - 1291 Title/Abstract Full Text Show Details

Sucic, Sonja; Bönisch, Heinz

Neuromethods, 2016 , vol. 118, p. 1 - 21 Title/Abstract Full Text Show Details

Dyb, Evelyn

International Journal of Drug Policy, 2016 , vol. 36, p. 76 - 84 Title/Abstract Full Text Show Details

Gauvin, David V.; Yoder, Joshua D.; Holdsworth, David L.; Harter, Marci L.; May, Jonelle R.; Cotey, Noelle; Dalton, Jill A.; Baird, Theodore J.

Journal of Pharmacological and Toxicological Methods, 2016 , vol. 82, p. 90 - 108 Title/Abstract Full Text Show Details

Jones, Alan Wayne; Holmgren, Anita; Ahlner, Johan

Forensic Science International, 2016 , vol. 267, p. 96 - 103


Title/Abstract Full Text Show Details

Marwaha, Steven; Thompson, Andrew; Bebbington, Paul; Singh, Swaran P.; Freeman, Daniel; Winsper, Catherine; Broome, Matthew R.

Psychiatry research, 2015 , vol. 229, # 1-2 p. 49 - 56 Title/Abstract Full Text Show Details

Jongkees, Bryant J.; Colzato, Lorenza S.

Neuroscience and Biobehavioral Reviews, 2016 , vol. 71, p. 58 - 82 Title/Abstract Full Text Show Details

Tremblay, Melanie; Winstanley, Catharine A.

Behavioural Brain Research, 2016 , vol. 314, p. 143 - 151 Title/Abstract Full Text Show Details

Ponzoni, Luisa; Sala, Mariaelvina; Braida, Daniela

Behavioural Brain Research, 2016 , vol. 314, p. 181 - 189 Title/Abstract Full Text Show Details

Schmitt, Andrea; Rujescu, Dan; Gawlik, Micha; Hasan, Alkomiet; Hashimoto, Kenji; Iceta, Sylvain; Jarema, Marek; Kambeitz, Joseph; Kasper, Siegfried; Keeser, Daniel; Kornhuber, Johannes; Koutsouleris, Nikolaos; Lanzenberger, Rupert; Malchow, Berend; Saoud, Mohamed; Spies, Marie; Stöber, Gerald; Thibaut, Florence; Riederer, Peter; Falkai, Peter

World Journal of Biological Psychiatry, 2016 , vol. 17, # 6 p. 406 - 428 Title/Abstract Full Text Show Details

Boronat-García, Alejandra; Palomero-Rivero, Marcela; Guerra-Crespo, Magdalena; Millán-Aldaco, Diana; Drucker-Colín, René

PLoS ONE, 2016 , vol. 11, # 8 art. no. E0160854 Title/Abstract Full Text Show Details

Mai, Bettina; Sommer, Susanne; Hauber, Wolfgang

International Journal of Neuropsychopharmacology, 2015 , vol. 18, # 10 Title/Abstract Full Text Show Details

Sinha; Lewis; Kumar; Yeruva; Curry

Case Reports in Cardiology, 2016 , vol. 2016, art. no. 2343691 Title/Abstract Full Text Show Details

Gentili, Stefano; Solimini, Renata; Tittarelli, Roberta; Mannocchi, Giulio; Busardò, Francesco Paolo

Journal of Analytical Methods in Chemistry, 2016 , vol. 2016, art. no. 1234581 Title/Abstract Full Text Show Details

Kedzierska, Ewa; Wach, Izabela

Current Issues in Pharmacy and Medical Sciences, 2016 , vol. 29, # 2 p. 61 - 65 Title/Abstract Full Text Show Details

67 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Hattingh, Hendrika Laetitia; Varsani, Janki; Kachouei, Leila Ataei; Parsons, Richard

Substance Abuse: Treatment, Prevention, and Policy, 2016 , vol. 11, # 1 art. no. 30 Title/Abstract Full Text Show Details

Alremeithi, Rashed H.; Meetani, Mohammed A.; Khalil, Saif. A.

RSC Advances, 2016 , vol. 6, # 84 p. 80576 - 80584 Title/Abstract Full Text Show Details

Gentile, Antonietta; Fresegna, Diego; Musella, Alessandra; Sepman, Helena; Bullitta, Silvia; De Vito, Francesca; Fantozzi, Roberta; Usiello, Alessandro; Maccarrone, Mauro; Mercuri, Nicola B.; Lutz, Beat; Mandolesi, Georgia; Centonze, Diego

Journal of Neuroinflammation, 2016 , vol. 13, # 1 art. no. 231 Title/Abstract Full Text Show Details

Tucker, Murray G.; Kekulawala, Sebastian; Kent, Michelle; Mostafa, Sam; Harvey, Richard

Journal of Medical Case Reports, 2016 , vol. 10, # 1 art. no. 242 Title/Abstract Full Text Show Details

Varriale, Antonio; Marzullo, Vincenzo Manuel; Di Giovanni, Stefano; Scala, Andrea; Capo, Alessandro; Majoli, Adelia; Pennacchio, Angela; Staiano, Maria; D’Auria, Sabato

Analytical and Bioanalytical Chemistry, 2016 , vol. 408, # 23 p. 6329 - 6336 Title/Abstract Full Text Show Details

Varriale, Antonio; Marzullo, Vincenzo Manuel; Di Giovanni, Stefano; Scala, Andrea; Capo, Alessandro; Majoli, Adelia; Pennacchio, Angela; Staiano, Maria; D’Auria, Sabato

Analytical and Bioanalytical Chemistry, 2016 , vol. 408, # 23 p. 6329 - 6336 Title/Abstract Full Text Show Details

Wearne, Travis A.; Parker, Lindsay M.; Franklin, Jane L.; Goodchild, Ann K.; Cornish, Jennifer L.

Neuropharmacology, 2016 , vol. 111, p. 107 - 118 Title/Abstract Full Text Show Details

Parr, Maria Kristina; Wuest, Bernhard; Naegele, Edgar; Joseph, Jan F.; Wenzel, Maxi; Schmidt, Alexander H.; Stanic, Mijo; de la Torre, Xavier; Botrè, Francesco

Analytical and Bioanalytical Chemistry, 2016 , vol. 408, # 24 p. 6789 - 6797 Title/Abstract Full Text Show Details

Parr, Maria Kristina; Wuest, Bernhard; Naegele, Edgar; Joseph, Jan F.; Wenzel, Maxi; Schmidt, Alexander H.; Stanic, Mijo; de la Torre, Xavier; Botrè, Francesco

Analytical and Bioanalytical Chemistry, 2016 , vol. 408, # 24 p. 6789 - 6797 Title/Abstract Full Text Show Details

Sárvári, Miklós; Deli, Levente; Kocsis, Pál; Márk, László; Maász, Gábor; Hrabovszky, Erik; Kalló, Imre; Gajári, Dávid; Vastagh, Csaba; Sümegi, Balázs; Tihanyi, Károly; Liposits, Zsolt

Brain Research, 2014 , vol. 1583, p. 1 - 11 Title/Abstract Full Text Show Details

Golovko; Bonitenko, E. Yu.; Ivanov; Barinov; Zatsepin

Neurochemical Journal, 2016 , vol. 10, # 3 p. 173 - 183 Title/Abstract Full Text Show Details

Cope, Zackary A.; Halberstadt, Adam L.; van Enkhuizen, Jordy; Flynn, Aaron D.; Breier, Michelle; Swerdlow, Neal R.; Geyer, Mark A.; Young, Jared W.

Psychopharmacology, 2016 , vol. 233, # 19-20 p. 3513 - 3525 Title/Abstract Full Text Show Details

Hambuchen, Michael D.; Rüedi-Bettschen, Daniela; Gunnell, Melinda G.; Hendrickson, Howard; Owens, S. Michael

Human Vaccines and Immunotherapeutics, 2016 , vol. 12, # 9 p. 2240 - 2248 Title/Abstract Full Text Show Details


Cansell; Castel; Denis; Rouch; Delbes; Martinez; Mestivier; Finan; Maldonado-Aviles; Rijnsburger; Tschöp; DiLeone; Eckel; La Fleur; Magnan; Hnasko; Luquet

Molecular Psychiatry, 2014 , vol. 19, # 10 p. 1095 - 1105 Title/Abstract Full Text Show Details

Papaseit, Esther; Pérez-Mañá, Clara; Mateus, Julián-Andrés; Pujadas, Mitona; Fonseca, Francina; Torrens, Marta; Olesti, Eulàlia; De La Torre, Rafael; Farre, Magi

Neuropsychopharmacology, 2016 , vol. 41, # 11 p. 2704 - 2713 Title/Abstract Full Text Show Details

Cooke, Tommi; So, Tsz-Yin

Current Pediatric Reviews, 2016 , vol. 12, # 3 p. 230 - 238 Title/Abstract Full Text Show Details

Dupuis, Marc; Baggio, Stéphanie; Accard, Marion Emilie; Mohler-Kuo, Meichun; Gmel, Gerhard

Drugs and Alcohol Today, 2016 , vol. 16, # 3 p. 212 - 221 Title/Abstract Full Text Show Details

Noven Pharmaceuticals, Inc.; Liu, Puchun; Dinh, Steven; Liao, Jun; Endo, Tsuyoshi

Patent: US2016/256406 A1, 2016 ; Title/Abstract Full Text Show Details

Bershad, Anya K.; Weafer, Jessica J.; Kirkpatrick, Matthew G.; Wardle, Margaret C.; Miller, Melissa A.; de Wit, Harriet

Social Neuroscience, 2016 , vol. 11, # 6 p. 592 - 599 Title/Abstract Full Text Show Details

Mowry, James B.; Spyker, Daniel A.; Cantilena, Louis R.; McMillan, Naya; Ford, Marsha

Clinical Toxicology, 2014 , vol. 52, # 10 p. 1032 - 1283 Title/Abstract Full Text Show Details

68 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Kumar, Nihit; Stowe, Zachary N.; Han, Xiaotong; Mancino, Michael J.

American Journal on Addictions, 2016 , vol. 25, # 7 p. 542 - 548 Title/Abstract Full Text Show Details

Lai, Wen-Sung; Chang, Chia-Yuan; Wong, Wan-Rong; Pei, Ju-Chun; Chen, Ya-Shan; Hung, Wei-Li

Current Pharmaceutical Design, 2014 , vol. 20, # 32 p. 5139 - 5149 Title/Abstract Full Text Show Details

Heravi, Majid M.; Zadsirjan, Vahideh; Dehghani, Mahzad

Current Organic Chemistry, 2016 , vol. 20, # 10 p. 1069 - 1134 Title/Abstract Full Text Show Details

Thomaidis, Nikolaos S.; Gago-Ferrero, Pablo; Ort, Christoph; Maragou, Niki C.; Alygizakis, Nikiforos A.; Borova, Viola L.; Dasenaki, Marilena E.

Environmental Science and Technology, 2016 , vol. 50, # 18 p. 10065 - 10072 Title/Abstract Full Text Show Details

González-Mariño, Iria; Gracia-Lor, Emma; Rousis, Nikolaos I.; Castrignanò, Erika; Thomas, Kevin V.; Quintana, José Benito; Kasprzyk-Hordern, Barbara; Zuccato, Ettore; Castiglioni, Sara

Environmental Science and Technology, 2016 , vol. 50, # 18 p. 10089 - 10096 Title/Abstract Full Text Show Details

Aotani, Daisuke; Son, Cheol; Shimizu, Yoshiyuki; Nomura, Hidenari; Hikida, Takatoshi; Kusakabe, Toru; Tanaka, Tomohiro; Miyazawa, Takashi; Hosoda, Kiminori; Nakao, Kazuwa

Neuroscience Letters, 2016 , vol. 633, p. 141 - 145 Title/Abstract Full Text Show Details

Petrie, Bruce; Gravell, Anthony; Mills, Graham A.; Youdan, Jane; Barden, Ruth; Kasprzyk-Hordern, Barbara

Environmental Science and Technology, 2016 , vol. 50, # 17 p. 9469 - 9478 Title/Abstract Full Text Show Details

Hamilton, Peter J.; Shekar, Aparna; Belovich, Andrea N.; Christianson, Nicole Bibus; Campbell, Nicholas G.; Sutcliffe, James S.; Galli, Aurelio; Matthies, Heinrich J.G.; Erreger, Kevin

Molecular Autism, 2015 , vol. 6, # 1 art. no. 8 Title/Abstract Full Text Show Details

Schacht

Pharmacogenomics Journal, 2016 , vol. 16, # 5 p. 430 - 438 Title/Abstract Full Text Show Details

Dougherty, Casey A.; Cai, Weibo; Hong, Hao

Current Topics in Medicinal Chemistry, 2015 , vol. 15, # 12 p. 1138 - 1152 Title/Abstract Full Text Show Details

Moreira, Rodrigo V.; da Costa, José L.; Menezes, Mauro R.; de Faria, Dalva L.A.

Vibrational Spectroscopy, 2016 , vol. 87, p. 104 - 110 Title/Abstract Full Text Show Details

Høiseth, Gudrun; Tuv, Silja Skogstad; Karinen, Ritva

Forensic Science International, 2016 , vol. 268, p. 35 - 38 Title/Abstract Full Text Show Details

Larney, Sarah; Mathers, Bradley M.; Poteat, Tonia; Kamarulzaman, Adeeba; Degenhardt, Louisa

Journal of Acquired Immune Deficiency Syndromes, 2015 , vol. 69, p. S100 - S109 Title/Abstract Full Text Show Details

Lee, Sylvia S.; Paspalof, Alexis M.; Snow, Daniel D.; Richmond, Erinn K.; Rosi-Marshall, Emma J.; Kelly, John J.

Environmental Science and Technology, 2016 , vol. 50, # 17 p. 9727 - 9735 Title/Abstract Full Text Show Details

Getasetegn, Million

Phytochemistry Reviews, 2016 , vol. 15, # 5 p. 907 - 920 Title/Abstract Full Text Show Details

Mazitov, Timur; Bregin, Aleksandr; Philips, Mari-Anne; Innos, Jürgen; Vasar, Eero

Behavioural Brain Research, 2017 , vol. 317, p. 311 - 318 Title/Abstract Full Text Show Details

Fosnocht, Anne Q.; Briand, Lisa A.

Physiology and Behavior, 2016 , vol. 166, p. 32 - 42 Title/Abstract Full Text Show Details

Beloate, Lauren N.; Omrani, Azar; Adan, Roger A.; Webb, Ian C.; Coolen, Lique M.

Journal of Neuroscience, 2016 , vol. 36, # 38 p. 9949 - 9961


Title/Abstract Full Text Show Details

Barnum, Richard

Adolescent Health, Medicine and Therapeutics, 2014 , vol. 5, p. 67 - 71 Title/Abstract Full Text Show Details

Righi, Federica; Polidori, Edoardo; Valletta, Enrico

Quaderni ACP, 2016 , vol. 23, # 5 p. 207 - 210 Title/Abstract Full Text Show Details

69 of 317

70 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Görgens, Christian; Guddat, Sven; Thomas, Andreas; Wachsmuth, Philipp; Orlovius, Anne-Katrin; Sigmund, Gerd; Thevis, Mario; Schänzer, Wilhelm

Journal of Pharmaceutical and Biomedical Analysis, 2016 , vol. 131, p. 482 - 496 Title/Abstract Full Text Show Details

Rezaei, Farzin; Emami, Maryam; Zahed, Shakiba; Morabbi, Mohammad-Javad; Farahzadi, Mohammadhadi; Akhondzadeh, Shahin

DARU, Journal of Pharmaceutical Sciences, 2015 , vol. 23, # 1 art. no. 2 Title/Abstract Full Text Show Details

Wright, Jackie; Edwards, John; Walker, Stewart

Reviews on Environmental Health, 2016 , vol. 31, # 3 p. 329 - 352 Title/Abstract Full Text Show Details

Philippu, Athineos

Current Medicinal Chemistry, 2016 , vol. 23, # 24 p. 2643 - 2652 Title/Abstract Full Text Show Details

Pitsikas, Nikolaos

Current Medicinal Chemistry, 2016 , vol. 23, # 24 p. 2692 - 2705 Title/Abstract Full Text Show Details

Woźniak, Monika; Acher, Francine; Marciniak, Marcin; Łasoń-Tyburkiewicz, Magdalena; Gruca, Piotr; Papp, Mariusz; Pilc, Andrzej; Wierońska, Joanna M.

Current Neuropharmacology, 2016 , vol. 14, # 5 p. 413 - 426 Title/Abstract Full Text Show Details

Hamidi, Samin; Khoubnasabjafari, Maryam; Ansarin, Khalil; Jouyban-Gharamaleki, Vahid; Jouyban, Abolghasem

Current Pharmaceutical Analysis, 2016 , vol. 12, # 2 p. 137 - 145 Title/Abstract Full Text Show Details

Ramachandra

Critical Reviews in Analytical Chemistry, 2016 , vol. 46, # 6 p. 482 - 489 Title/Abstract Full Text Show Details

Camacho-Muñoz, Dolores; Petrie, Bruce; Castrignanò, Erika; Kasprzyk-Hordern, Barbara

Current Analytical Chemistry, 2016 , vol. 12, # 4 p. 303 - 314 Title/Abstract Full Text Show Details

Baalbaki, Zeina; Sultana, Tamanna; Maere, Thomas; Vanrolleghem, Peter A.; Metcalfe, Chris D.; Yargeau, Viviane

Science of the Total Environment, 2016 , vol. 573, p. 1147 - 1158 Title/Abstract Full Text Show Details

Estrada-Arriaga, Edson Baltazar; Cortés-Muñoz, Juana Enriqueta; González-Herrera, Arturo; Calderón-Mólgora, César Guillermo; de Lourdes Rivera-Huerta, Ma.; Ramírez-Camperos, Esperanza; Montellano-Palacios, Leticia; Gelover-Santiago, Silvia Lucila; Pérez-Castrejón, Sara; Cardoso-Vigueros, Lina; Martín-Domínguez, Alejandra; García-Sánchez, Liliana

Science of the Total Environment, 2016 , vol. 571, p. 1172 - 1182 Title/Abstract Full Text Show Details

Weyandt, Lisa L.; Oster, Danielle R.; Marraccini, Marisa E.; Gudmundsdottir, Bergljot Gyda; Munro, Bailey A.; Rathkey, Emma S.; McCallum, Alison

Experimental and Clinical Psychopharmacology, 2016 , vol. 24, # 5 p. 400 - 414 Title/Abstract Full Text Show Details

Meyer, Markus R.

Archives of Toxicology, 2016 , vol. 90, # 10 p. 2421 - 2444 Title/Abstract Full Text Show Details

Soussan, Christophe; Kjellgren, Anette

International Journal of Drug Policy, 2016 , vol. 32, p. 77 - 84 Title/Abstract Full Text Show Details

Oswald, Lynn M.; Wand, Gary S.

NeuroImage, 2016 , vol. 125, p. 1096 - 1098 Title/Abstract Full Text Show Details

Caudevilla, Fernando; Ventura, Mireia; Fornís, Iván; Barratt, Monica J.; Vidal, Claudio; lladanosa, Cristina Gil; Quintana, Pol; Muñoz, Ana; Calzada, Nuria

International Journal of Drug Policy, 2016 , vol. 35, p. 38 - 41 Title/Abstract Full Text Show Details

Banks, Matthew L.

Drug and Alcohol Dependence, 2016 , vol. 165, p. 260 - 264 Title/Abstract Full Text Show Details

Kankaanpää, Aino; Ariniemi, Kari; Heinonen, Mari; Kuoppasalmi, Kimmo; Gunnar, Teemu

Science of the Total Environment, 2016 , vol. 568, p. 864 - 874 Title/Abstract Full Text Show Details

van Wel; Kinyua; van Nuijs; Salvatore; Bramness; Covaci; Van Hal

International Journal of Drug Policy, 2016 , vol. 34, p. 20 - 26 Title/Abstract Full Text Show Details

Lile, Joshua A.; Stoops, William W.; Rush, Craig R.; Negus, S. Stevens; Glaser, Paul E.A.; Hatton, Kevin W.; Hays, Lon R.

Drug and Alcohol Dependence, 2016 , vol. 165, p. 111 - 119 Title/Abstract Full Text Show Details

Comment (Pharmacological Data)

Bioactivities present

Reference

Karkhanis, Anushree N.; Beveridge, Thomas J.R.; Blough, Bruce E.; Jones, Sara R.; Ferris, Mark J.


Drug and Alcohol Dependence, 2016 , vol. 166, p. 51 - 60 Title/Abstract Full Text Show Details

Managò, Francesca; Mereu, Maddalena; Mastwal, Surjeet; Mastrogiacomo, Rosa; Scheggia, Diego; Emanuele, Marco; De Luca, Maria A.; Weinberger, Daniel R.; Wang, Kuan Hong; Papaleo, Francesco

Cell Reports, 2016 , vol. 16, # 8 p. 2116 - 2128 Title/Abstract Full Text Show Details

Tierney, Aaron A.; Hart, Carl L.

NeuroImage, 2016 , vol. 125, p. 1095 - 1095 Title/Abstract Full Text Show Details

Lander, Sharon S.; Linder-Shacham, Donna; Gaisler-Salomon, Inna

Behavioural Brain Research, 2017 , vol. 316, p. 245 - 254 Title/Abstract Full Text Show Details

Telving, Rasmus; Hasselstrøm, Jørgen Bo; Andreasen, Mette Findal

Forensic Science International, 2016 , vol. 266, p. 453 - 461 Title/Abstract Full Text Show Details

Kyriakou, Chrystalla; Marchei, Emilia; Scaravelli, Giulia; García-Algar, Oscar; Supervía, August; Graziano, Silvia

Journal of Pharmaceutical and Biomedical Analysis, 2016 , vol. 128, p. 53 - 60 Title/Abstract Full Text Show Details

Gicquel, Thomas; Hugbart, Chloé; Le Devehat, Françoise; Lepage, Sylvie; Baert, Alain; Bouvet, Renaud; Morel, Isabelle

Forensic Science International, 2016 , vol. 266, p. e38 - e42 Title/Abstract Full Text Show Details

El-Mallakh, Rif S.; Roberts, R. Jeannie; El-Mallakh, Peggy L.; Findlay, Lillian Jan; Reynolds, Kristen K.

Clinics in Laboratory Medicine, 2016 , vol. 36, # 3 p. 507 - 523 Title/Abstract Full Text Show Details

Daneschvar, Homayoun L.; Aronson, Mark D.; Smetana, Gerald W.

American Journal of Medicine, 2016 , vol. 129, # 8 p. 1 - 6,879 Title/Abstract Full Text Show Details

Peleg-Raibstein; Sarker; Litwan; Krämer; Ametamey; Schibli; Wolfrum

Translational Psychiatry, 2016 , vol. 6, # 10 art. no. E911 Title/Abstract Full Text Show Details

Hussain, Shahzad; Khattak, Zainab; Mahmood, Sidra; Malik, Farnaz; Riaz, Humayun; Raza, Syed Atif; Khan, Samiullah

Pakistan Journal of Pharmaceutical Sciences, 2016 , vol. 29, # 5 p. 1639 - 1648 Title/Abstract Full Text Show Details

Gentili, Stefano; Mortali, Claudia; Mastrobattista, Luisa; Berretta, Paolo; Zaami, Simona

Journal of Pharmaceutical and Biomedical Analysis, 2016 , vol. 129, p. 282 - 287 Title/Abstract Full Text Show Details

Spiegel, David R.; McCroskey, Aidan; Puaa, Kapaakea; Meeker, Grant; Hartman, Lauren; Hudson, Joshua; Hung, Yu C.

Clinical Neuropharmacology, 2016 , vol. 39, # 5 p. 272 - 275 Title/Abstract Full Text Show Details

Pike, Erika; Stoops, William W.; Rush, Craig R.

Pharmacology Biochemistry and Behavior, 2016 , vol. 150-151, p. 87 - 93 Title/Abstract Full Text Show Details

Nikfarjam, Ali; Shokoohi, Mostafa; Shahesmaeili, Armita; Haghdoost, Ali Akbar; Baneshi, Mohammad Reza; Haji-Maghsoudi, Saiedeh; Rastegari, Azam; Nasehi, Abbas Ali; Memaryan, Nadereh; Tarjoman, Termeh

International Journal of Drug Policy, 2016 , vol. 31, p. 147 - 152 Title/Abstract Full Text Show Details

Lee, Hun Joo; Han, Eunyoung; Lee, Jaesin; Chung, Heesun; Min, Sung-Gi

Forensic Science International, 2016 , vol. 268, p. 116 - 122 Title/Abstract Full Text Show Details

Donegani, Enrico; Paal, Peter; Küpper, Thomas; Hefti, Urs; Basnyat, Buddha; Carceller, Anna; Bouzat, Pierre; Van Der Spek, Rianne; Hillebrandt, David

High Altitude Medicine and Biology, 2016 , vol. 17, # 3 p. 157 - 184 Title/Abstract Full Text Show Details

Hussain; Cossette; Brake

Journal of Neuroendocrinology, 2016 , vol. 28, # 5 p. 10 Title/Abstract Full Text Show Details

Alessandri, Ivano; Vassalini, Irene; Bertuzzi, Michela; Bontempi, Nicolò; Memo, Maurizio; Gianoncelli, Alessandra

Scientific Reports, 2016 , vol. 6, art. no. 34521 Title/Abstract Full Text Show Details

Volkow; Wang; Logan; Alexoff; Fowler; Thanos; Wong; Casado; Ferre; Tomasi

Translational Psychiatry, 2015 , vol. 5, # 4 art. no. A046 Title/Abstract Full Text Show Details

71 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Andrés-Costa, María Jesús; Andreu, Vicente; Picó, Yolanda

Journal of Chromatography A, 2016 , vol. 1461, p. 98 - 106 Title/Abstract Full Text Show Details

Punja, Salima; Schmid, Christopher H.; Hartling, Lisa; Urichuk, Liana; Nikles, Catherine Jane; Vohra, Sunita

Journal of Clinical Epidemiology, 2016 , vol. 76, p. 76 - 81 Title/Abstract Full Text Show Details

Freeman; Rice; Soto; Pate; Weed; Ator; DeLeon; Wong; Zhou; Mankowski; Zink; Adams; Hutchinson

Translational Psychiatry, 2015 , vol. 5, # 5 art. no. E567 Title/Abstract Full Text Show Details

Smucny; Stevens; Olincy; Tregellas

Translational Psychiatry, 2015 , vol. 5, # 6 art. no. E587 Title/Abstract Full Text Show Details

Li; Leung; Zhou; Ho; Kong; Basil; Wei; Lam; Zhang; Law; Chua; Sham; Wu; McAlonan

Translational Psychiatry, 2015 , vol. 5, # 9 art. no. E641 Title/Abstract Full Text Show Details

Punja, Salima; Xu, Dongying; Schmid, Christopher H.; Hartling, Lisa; Urichuk, Liana; Nikles, Catherine Jane; Vohra, Sunita

Journal of Clinical Epidemiology, 2016 , vol. 76, p. 65 - 75 Title/Abstract Full Text Show Details

Jin, Yunju; Dougherty, Sarah E.; Wood, Kevin; Sun, Landy; Cudmore, Robert H.; Abdalla, Aya; Kannan, Geetha; Pletnikov,


Mikhail; Hashemi, Parastoo; Linden, David J.

Neuron, 2016 , vol. 91, # 4 p. 748 - 762 Title/Abstract Full Text Show Details

Saz; Marina

Journal of Chromatography A, 2016 , vol. 1467, p. 79 - 94 Title/Abstract Full Text Show Details

Gan, Jinping; Ma, Shuguang; Zhang, Donglu

Drug Metabolism Reviews, 2016 , vol. 48, # 4 p. 473 - 501 Title/Abstract Full Text Show Details

Posadzki, Pawel; Khalil, Mohamed M. K.; AlBedah, Abdullah M. N.; Zhabenko, Olena; Car, Josip

Focus on Alternative and Complementary Therapies, 2016 , vol. 21, # 2 p. 69 - 81 Title/Abstract Full Text Show Details

Hyun, Myung Ho

Journal of Chromatography A, 2016 , vol. 1467, p. 19 - 32 Title/Abstract Full Text Show Details

Bäckberg, Matilda; Westerbergh, Jenny; Beck, Olof; Helander, Anders

Clinical Toxicology, 2016 , vol. 54, # 9 p. 819 - 825 Title/Abstract Full Text Show Details

Cumming, Craig; Troeung, Lakkhina; Young, Jesse T.; Kelty, Erin; Preen, David B.

Drug and Alcohol Dependence, 2016 , vol. 168, p. 263 - 273 Title/Abstract Full Text Show Details

Ford, Loretta T; Berg, Jonathan D

Annals of Clinical Biochemistry, 2016 , vol. 53, # 6 p. 640 - 646 Title/Abstract Full Text Show Details

Priebe, Stefan; Bremner, Stephen A.; Lauber, Christoph; Henderson, Catherine; Burns, Tom

Health Technology Assessment, 2016 , vol. 20, # 70 p. v Title/Abstract Full Text Show Details

Foster, Daniel J.; Wilson, Jermaine M.; Remke, Daniel H.; Mahmood, M. Suhaib; Uddin, M. Jashim; Wess, Jürgen; Patel, Sachin; Marnett, Lawrence J.; Niswender, Colleen M.; Jones, Carrie K.; Xiang, Zixiu; Lindsley, Craig W.; Rook, Jerri M.; Conn, P. Jeffrey

Neuron, 2016 , vol. 91, # 6 p. 1244 - 1252 Title/Abstract Full Text Show Details

Cunningham, Scott; Finlay, Keith

Health Economics (United Kingdom), 2016 , vol. 25, # 10 p. 1268 - 1290 Title/Abstract Full Text Show Details

Jain; Arya; Inamdar; Auti; Unawane; Puranik; Sanap; Inamke; Mahale; Prajapati; Shishoo

Current Topics in Medicinal Chemistry, 2016 , vol. 16, # 28 p. 3133 - 3174 Title/Abstract Full Text Show Details

Kristofic, John J.; Chmiel, Jeffrey D.; Jackson, George F.; Vorce, Shawn P.; Holler, Justin M.; Robinson, Stephen L.; Bosy, Thomas Z.

Journal of Analytical Toxicology, 2016 , vol. 40, # 6 art. no. BKW035, p. 466 - 472 Title/Abstract Full Text Show Details

Vijayakumar, Arumugam Ramamoorthy; Biswas, Nihar Ranjan; Menon, Vimla; Saxena, Rohit; Ahmed, Warisha; Halder, Nabanita; Velpandian, Thirumurthy

Indian Journal of Physiology and Pharmacology, 2016 , vol. 60, # 2 p. 182 - 192 Title/Abstract Full Text Show Details

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Comment (Pharmacological Data)

Bioactivities present

Reference

Arredondo, Cristian; González, Marcela; Andrés, María Estela; Gysling, Katia

Brain Research, 2016 , vol. 1652, p. 14 - 20 Title/Abstract Full Text Show Details

Amin, Bahareh; Andalib, Sasan; Vaseghi, Golnaz; Mesripour, Azadeh

Iranian Journal of Psychiatry and Behavioral Sciences, 2016 , vol. 10, # 2 art. no. E1822 Title/Abstract Full Text Show Details

Peng, Yan; Hall, Sarah; Gautam, Lata

TrAC - Trends in Analytical Chemistry, 2016 , vol. 85, p. 232 - 240 Title/Abstract Full Text Show Details

Haglock-Adler, Carrie J.; McMillin, Gwendolyn A.; Strathmann, Frederick G.

Clinical Biochemistry, 2016 , vol. 49, # 13-14 p. 1092 - 1095 Title/Abstract Full Text Show Details

Kueh, Shaw-Hua (Anthony); Gabriel, Ruvin S.; Lund, Mayanna; Sutton, Tim; Bradley, Joshua; Kerr, Andrew J.; Looi, Jen-Li

Heart Lung and Circulation, 2016 , vol. 25, # 11 p. 1087 - 1093 Title/Abstract Full Text Show Details

Kang, Shuo; Wu, Mariah M.; Galvez, Roberto; Gulley, Joshua M.

Neuroscience, 2016 , vol. 339, p. 72 - 84 Title/Abstract Full Text Show Details

Amador, Ariadna; Huitron-Resendiz, Salvador; Roberts, Amanda J.; Kamenecka, Theodore M.; Solt, Laura A.; Burris, Thomas P. Burris

PLoS ONE, 2016 , vol. 11, # 9 art. no. E0162452 Title/Abstract Full Text Show Details

Castello, Stefania; D'Aloisio, Genesis; Arias, Carlos; Molina, Juan Carlos

Pharmacology Biochemistry and Behavior, 2016 , vol. 150-151, p. 68 - 75 Title/Abstract Full Text Show Details

Asser, Andres; Kõks, Sulev; Snellman, Anniina; Haaparanta-Solin, Merja; Arponen, Eveliina; Grönroos, Tove; Nairismägi, Jaak; Bergquist, Jonas; Soomets, Ursel; Piip, Piret; Eltermaa, Mall; Sauk, Martin; Lindmäe, Hanna; Rinne, Juha O.; Taba, Pille

Brain Research, 2016 , vol. 1652, p. 97 - 102 Title/Abstract Full Text Show Details

Salomone; Tsanaclis; Agius; Kintz; Baumgartner

Drug Testing and Analysis, 2016 , vol. 8, # 10 p. 996 - 1004 Title/Abstract Full Text Show Details

Chiu, Zelia K.; Bennett, Iwan E.; Chan, Patrick; Rosenfeld, Jeffrey V.

Journal of Clinical Neuroscience, 2016 , vol. 32, p. 137 - 139


Title/Abstract Full Text Show Details

Vanderschuren, Louk J.M.J.; Achterberg, E.J. Marijke; Trezza, Viviana

Neuroscience and Biobehavioral Reviews, 2016 , vol. 70, p. 86 - 105 Title/Abstract Full Text Show Details

Spear, Linda Patia

Neuroscience and Biobehavioral Reviews, 2016 , vol. 70, p. 228 - 243 Title/Abstract Full Text Show Details

Bumbrah, Gurvinder Singh; Sharma, Rakesh Mohan

Egyptian Journal of Forensic Sciences, 2016 , vol. 6, # 3 p. 209 - 215 Title/Abstract Full Text Show Details

Mychasiuk, Richelle; Metz, Gerlinde A.S.

Neuroscience and Biobehavioral Reviews, 2016 , vol. 70, p. 189 - 197 Title/Abstract Full Text Show Details

Beerepoot, Pieter; Lam, Vincent M.; Salahpour, Ali

Journal of Biological Chemistry, 2016 , vol. 291, # 42 p. 22053 - 22062 Title/Abstract Full Text Show Details

Kutlu, Munir Gunes; Gould, Thomas J.

Learning and Memory, 2016 , vol. 23, # 10 p. 515 - 533 Title/Abstract Full Text Show Details

Lang, Juliane; Dettmeyer, Reinhard; Henn, Veroniqué; Birngruber, Christoph G.; Veit, Florian

Romanian Journal of Legal Medicine, 2016 , vol. 24, # 3 p. 212 - 215 Title/Abstract Full Text Show Details

Wiergowski, Marek; Anand, Jacek Sein; Karnecki, Karol; Sołtyszewski, Ireneusz; Jankowski, Zbigniew

Romanian Journal of Legal Medicine, 2016 , vol. 24, # 3 p. 219 - 225 Title/Abstract Full Text Show Details

Drinkenburg, Wilhelmus H.I.M.; Ruigt, Gé S.F.; Ahnaou, Abdallah

Neuropsychobiology, 2016 , vol. 72, # 3-4 p. 151 - 164 Title/Abstract Full Text Show Details

73 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Feng, Ling-Yi; Yu, Wen-Jing; Chang, Wei-Ting; Han, Eunyoung; Chung, Heesun; Li, Jih-Heng

Substance Abuse: Treatment, Prevention, and Policy, 2016 , vol. 11, # 1 art. no. 34 Title/Abstract Full Text Show Details

Thorley, Emma; Kang, Isaac; D'Costa, Stephanie; Vlazaki, Myrto; Ayeko, Olaoluwa; Arbe-Barnes, Edward H.; Swerner, Casey B.

Philosophy, Ethics, and Humanities in Medicine, 2016 , vol. 11, # 1 art. no. 6 Title/Abstract Full Text Show Details

Milienne-Petiot, Morgane; Kesby, James P.; Graves, Mary; van Enkhuizen, Jordy; Semenova, Svetlana; Minassian, Arpi; Markou, Athina; Geyer, Mark A.; Young, Jared W.

Neuropharmacology, 2017 , vol. 113, p. 260 - 270 Title/Abstract Full Text Show Details

Trossbach; Bader; Hecher; Pum; Masoud; Prikulis; Schäble; De Souza Silva; Su; Boulat; Chwiesko; Poschmann; Stühler; Lohr; Stout; Oskamp; Godsave; Müller-Schiffmann; Bilzer; Steiner; Peters; Bauer; Sauvage; Ramsey; Miller; Liu; Seeman; Brandon; Huston; Korth

Molecular Psychiatry, 2016 , vol. 21, # 11 p. 1561 - 1572 Title/Abstract Full Text Show Details

Andersen, Jacob; Ladefoged, Lucy Kate; Kristensen, Trine N. Bjerre; Munro, Lachlan; Grouleff, Julie; Stuhr-Hansen, Nicolai; Kristensen, Anders S.; Schiøtt, Birgit; Strømgaard, Kristian

ACS Chemical Neuroscience, 2016 , vol. 7, # 10 p. 1406 - 1417 Title/Abstract Full Text Show Details

Nieddu, Maria; Burrai, Lucia; Baralla, Elena; Pasciu, Valeria; Varoni, Maria Vittoria; Briguglio, Irene; Demontis, Maria Piera; Boatto, Gianpiero

Journal of Analytical Toxicology, 2016 , vol. 40, # 7 p. 492 - 497 Title/Abstract Full Text Show Details

Mallet, Claude; Botch-Jones, Sabra

Journal of Analytical Toxicology, 2016 , vol. 40, # 8 art. no. BKW082, p. 617 - 627 Title/Abstract Full Text Show Details

Rosano, Thomas G.; Ohouo, Patrice Y.; LeQue, John J.; Freeto, Scott M.; Wood, Michelle

Journal of Analytical Toxicology, 2016 , vol. 40, # 8 art. no. BKW050, p. 628 - 638 Title/Abstract Full Text Show Details

Gogliotti, Rocco G.; Senter, Rebecca K.; Rook, Jerri M.; Ghoshal, Ayan; Zamorano, Rocio; Malosh, Chrysa; Stauffer, Shaun R.; Bridges, Thomas M.; Bartolome, Jose M.; Daniels, J. Scott; Jones, Carrie K.; Lindsley, Craig W.; Conn, P. Jeffrey; Niswender, Colleen M.

Human Molecular Genetics, 2016 , vol. 25, # 10 art. no. DDW074, p. 1990 - 2004 Title/Abstract Full Text Show Details

Fassette, Timothy; Martinez, Afton

Journal of Analytical Toxicology, 2016 , vol. 40, # 8 art. no. BKW054, p. 700 - 702 Title/Abstract Full Text Show Details

Morozova, Ekaterina; Yoo, Yeonjoo; Behrouzvaziri, Abolhassan; Zaretskaia, Maria; Rusyniak, Daniel; Zaretsky, Dmitry; Molkov, Yaroslav

Physiological Reports, 2016 , vol. 4, # 17 art. no. E12955 Title/Abstract Full Text Show Details

Mellsop, Graham; Choi; Every-Palmer, Susanna; Green, Bob; Heffernan, Ed; Kachaeva, Margarita; Shiina, Akihiro; Wang, Xiaoping

International Journal of Law and Psychiatry, 2016 , vol. 47, p. 68 - 73 Title/Abstract Full Text Show Details

Ceretta, Ana Paula Chiapinotto; Schaffer, Larissa Finger; de Freitas, Catiuscia Molz; Reinheimer, Jeane Binotto; Dotto, Mariana Maikéli; Fachinetto, Roselei

Schizophrenia Research, 2016 , vol. 175, # 1-3 p. 230 - 231 Title/Abstract Full Text Show Details

Engelke, Douglas Senna; Filev, Renato; Mello, Luiz E.; Santos-Junior, Jair Guilherme

Behavioural Brain Research, 2017 , vol. 317, p. 522 - 527 Title/Abstract Full Text Show Details


Thevis, Mario; Geyer, Hans; Tretzel, Laura; Schänzer, Wilhelm

Journal of Pharmaceutical and Biomedical Analysis, 2016 , vol. 130, p. 220 - 230 Title/Abstract Full Text Show Details

Kailasa, Suresh Kumar; Wu, Hui-Fen

Current Neuropharmacology, 2013 , vol. 11, # 4 p. 436 - 464 Title/Abstract Full Text Show Details

Khalilian, Faezeh; Rezaee, Mohammad

Journal of the Brazilian Chemical Society, 2016 , vol. 27, # 11 p. 2105 - 2113 Title/Abstract Full Text Show Details

Mercolini, Laura; Protti, Michele

Journal of Pharmaceutical and Biomedical Analysis, 2016 , vol. 130, p. 202 - 219 Title/Abstract Full Text Show Details

Sealover, Natalie R.; Felts, Bruce; Kuntz, Charles P.; Jarrard, Rachel E.; Hockerman, Gregory H.; Barker, Eric L.; Henry, L. Keith

Biochemical Pharmacology, 2016 , vol. 120, p. 46 - 55 Title/Abstract Full Text Show Details

Simonsen, Ulf; Comerma-Steffensen, Simon; Andersson, Karl-Erik

Basic and Clinical Pharmacology and Toxicology, 2016 , vol. 119, p. 63 - 74 Title/Abstract Full Text Show Details

74 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Shin, Eun-Joo; Nam, Yunsung; Lee, Ji Won; Nguyen, Phuong-Khue Thi; Yoo, Ji Eun; Tran, The-Vinh; Jeong, Ji Hoon; Jang, Choon-Gon; Oh, Young J.; Youdim, Moussa B. H.; Lee, Phil Ho; Nabeshima, Toshitaka; Kim, Hyoung-Chun

Molecular Neurobiology, 2016 , vol. 53, # 9 p. 6251 - 6269 Title/Abstract Full Text Show Details

Krauss, Shannon T.; Remcho, Thomas P.; Lipes, Shelby M.; Aranda, Roman; Maynard, Henry P.; Shukla, Nishant; Li, Jingyi; Tontarski, Richard E.; Landers, James P.

Analytical Chemistry, 2016 , vol. 88, # 17 p. 8689 - 8697 Title/Abstract Full Text Show Details

Rentsch, Katharina M.

TrAC - Trends in Analytical Chemistry, 2016 , vol. 84, p. 88 - 93 Title/Abstract Full Text Show Details

Bhattacharjee, Nivedita; Borah, Anupom

Neurochemistry International, 2016 , vol. 101, p. 48 - 55 Title/Abstract Full Text Show Details

Singer, Bryan F.; Bubula, Nancy; Przybycien-Szymanska, Magdalena M.; Li, Dongdong; Vezina, Paul

European Neuropsychopharmacology, 2016 , vol. 26, # 11 p. 1836 - 1842 Title/Abstract Full Text Show Details

Guatteo, Ezia; Rizzo, Francesca Romana; Federici, Mauro; Cordella, Alberto; Ledonne, Ada; Latini, Laura; Nobili, Annalisa; Viscomi, Maria Teresa; Biamonte, Filippo; Landrock, Kerstin K.; Martini, Alessandro; Aversa, Daniela; Schepisi, Chiara; D'Amelio, Marcello; Berretta, Nicola; Mercuri, Nicola B.

Experimental Neurology, 2017 , vol. 287, p. 21 - 33 Title/Abstract Full Text Show Details

Vicente-Rodríguez, Marta; Rojo Gonzalez, Loreto; Gramage, Esther; Fernández-Calle, Rosalía; Chen, Ying; Pérez-García, Carmen; Ferrer-Alcón, Marcel; Uribarri, María; Bailey, Alexis; Herradón, Gonzalo

European Neuropsychopharmacology, 2016 , vol. 26, # 11 p. 1794 - 1805 Title/Abstract Full Text Show Details

dos Santos, Vagner Bezerra; Daniel, Daniela; Singh, Melina; do Lago, Claudimir Lucio

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2016 , vol. 1038, p. 19 - 25 Title/Abstract Full Text Show Details

Gupta, Kunal; Muhammed, Hazif; Fazil; Kamath, Jagadish V.

International Journal of Pharmaceutical Sciences Review and Research, 2016 , vol. 40, # 2 art. no. 26, p. 122 - 125 Title/Abstract Full Text Show Details

Chen, Pai-Shan; Chen, Shu-Hua; Chen, Jung-Hsuan; Haung, Wan-Yun; Liu, Hsin-Tung; Kong, Po-Hsin; Yang, Olivia HsuYuan

Analytica Chimica Acta, 2016 , vol. 946, p. 1 - 8 Title/Abstract Full Text Show Details

Hernaus; Mehta

NeuroImage, 2016 , vol. 142, p. 663 - 667 Title/Abstract Full Text Show Details

Sun, Ying-pei; Ha, Wei; Chen, Juan; Qi, Huan-yang; Shi, Yan-ping

TrAC - Trends in Analytical Chemistry, 2016 , vol. 84, p. 12 - 21 Title/Abstract Full Text Show Details

Putnam-Hornstein, Emily; Prindle, John J.; Leventhal, John M.

Pediatrics, 2016 , vol. 138, # 3 art. no. E20161273 Title/Abstract Full Text Show Details

Bezhentsev, Vladislav M.; Tarasova, Olga A.; Dmitriev, Aleksandr V.; Rudik, Anastasiya V.; Lagunin, Aleksey A.; Filimonov, Dmitriy A.; Poroikov, Vladimir V.

Russian Chemical Reviews, 2016 , vol. 85, # 8 p. 854 - 879 Title/Abstract Full Text Show Details

Xu, Xiaomeng; Ma, Shifan; Feng, Zhiwei; Hu, Guanxing; Wang, Lirong; Xie, Xiang-Qun

Journal of Molecular Graphics and Modelling, 2016 , vol. 70, p. 284 - 295 Title/Abstract Full Text Show Details

Michelis, Joan Philipp; Zimmermann, Julian; Bedarf, Janis Rebecca; Bundschuh, Ralph; Gaertner, Florian C.; Paus

Parkinsonism and Related Disorders, 2016 , vol. 31, p. 153 - 155 Title/Abstract Full Text Show Details

Gauvin, David V.; Zimmermann, Zachary J.; Kallman, Mary Jeanne

Drug and Alcohol Dependence, 2016 , vol. 168, p. 307 - 319 Title/Abstract Full Text Show Details

Hutsell, Blake A.; Negus, S. Stevens; Banks, Matthew L.

Drug and Alcohol Dependence, 2016 , vol. 168, p. 36 - 44 Title/Abstract Full Text Show Details

Gartziandia; Herrán; Ruiz-Ortega; Miguelez; Igartua; Lafuente; Pedraz; Ugedo; Hernández


Journal of Biomedical Nanotechnology, 2016 , vol. 12, # 12 p. 2220 - 2230 Title/Abstract Full Text Show Details

Becker, Jill B.; McClellan, Michele L.; Reed, Beth Glover

Journal of Neuroscience Research, 2017 , vol. 95, # 1-2 p. 136 - 147 Title/Abstract Full Text Show Details

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76 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Orsini, Caitlin A.; Setlow, Barry

Journal of Neuroscience Research, 2017 , vol. 95, # 1-2 p. 260 - 269 Title/Abstract Full Text Show Details

Bundgaard, Christoffer; Montezinho, Liliana P.; Anderson, Neil; Thomsen, Christian; Mørk, Arne

Pharmacology Biochemistry and Behavior, 2016 , vol. 150-151, p. 147 - 152 Title/Abstract Full Text Show Details

Wang, Sheng-Min; Han, Changsu; Lee, Soo-Jung; Jun, Tae-Youn; Patkar, Ashwin A.; Masand, Prakash S.; Pae, Chi-Un

Journal of Psychiatric Research, 2017 , vol. 84, p. 292 - 300 Title/Abstract Full Text Show Details

Luhrs, Lauren; Manlapaz, Cynthia; Kedzie, Karen; Rao, Sandhya; Cabrera-Ghayouri, Sara; Donello, John; Gil, Daniel

Neuroscience, 2016 , vol. 339, p. 608 - 621 Title/Abstract Full Text Show Details

Childs, Emma; de Wit, Harriet

Addiction, 2016 , vol. 111, # 12 p. 2157 - 2165 Title/Abstract Full Text Show Details

Moehlecke, Milene; Canani, Luis Henrique; e Silva, Lucas Oliveira Junqueira; Trindade, Manoel Roberto Maciel; Friedman, Rogerio; Leitão, Cristiane Bauermann

Archives of Endocrinology and Metabolism, 2016 , vol. 60, # 2 p. 152 - 162 Title/Abstract Full Text Show Details

Juurmaa, Julius; Menke, Ricarda A. L.; Vila, Pierre; Müürsepp, Andreas; Tomberg, Tiiu; Ilves, Pilvi; Nigul, Mait; JohansenBerg, Heidi; Donaghy, Michael; Stagg, Charlotte J.; Stepens, Ainārs; Taba, Pille

Brain and Behavior, 2016 , vol. 6, # 11 art. no. E00539 Title/Abstract Full Text Show Details

Cheng, Vincent; Inaba, Kenji; Johnson, Megan; Byerly, Saskya; Jiang, Yue; Matsushima, Kazuhide; Haltmeier, Tobias; Benjamin, Elizabeth; Lam, Lydia; Demetriades, Demetrios

Journal of Trauma and Acute Care Surgery, 2016 , vol. 81, # 5 p. 913 - 920 Title/Abstract Full Text Show Details

Saka, Cafer

Critical Reviews in Analytical Chemistry, 2017 , vol. 47, # 1 p. 1 - 23 Title/Abstract Full Text Show Details

White, Tara L.

Current Opinion in Behavioral Sciences, 2017 , vol. 13, p. 63 - 70 Title/Abstract Full Text Show Details

Mack, Josiel Mileno; Schamne, Marissa Giovanna; Sampaio, Tuane Bazanella; Pértile, Renata Aparecida Nedel; Fernandes, Pedro Augusto Carlos Magno; Markus, Regina P.; Prediger, Rui Daniel

Oxidative Medicine and Cellular Longevity, 2016 , vol. 2016, art. no. 3472032 Title/Abstract Full Text Show Details

Shen, Erica Y.; Jiang, Yan; Javidfar, Behnam; Kassim, Bibi; Loh, Yong-Hwee E.; Ma, Qi; Mitchell, Amanda C.; Pothula, Venu; Stewart, A Francis; Ernst, Patricia; Yao, Wei-Dong; Martin, Gilles; Shen, Li; Jakovcevski, Mira; Akbarian, Schahram

Neuropsychopharmacology, 2016 , vol. 41, # 13 p. 3103 - 3113 Title/Abstract Full Text Show Details

Barkus, Chris; Korn, Clio; Stumpenhorst, Katharina; Laatikainen, Linda M.; Ballard, Dominic; Lee, Sheena; Sharp, Trevor; Harrison, Paul J.; Bannerman, David M.; Weinberger, Daniel R.; Chen, Jingshan; Tunbridge, Elizabeth M.

Neuropsychopharmacology, 2016 , vol. 41, # 13 p. 3060 - 3069 Title/Abstract Full Text Show Details

Boileau, Isabelle; Payer, Doris; Rusjan, Pablo M.; Houle, Sylvain; Tong, Junchao; McCluskey, Tina; Wilson, Alan A.; Kish, Stephen J.

Neuropsychopharmacology, 2016 , vol. 41, # 13 p. 2994 - 3002 Title/Abstract Full Text Show Details

Bora, Feyza; Yılmaz, Fatih; Bora, Taner

Iranian Journal of Basic Medical Sciences, 2016 , vol. 19, # 11 p. 1151 - 1158 Title/Abstract Full Text Show Details

Clasen, Matthew M.; Wetzell, Bradley B.; Riley, Anthony L.

Learning and Behavior, 2016 , vol. 44, # 4 p. 356 - 365 Title/Abstract Full Text Show Details

Abourashed, Ehab A.; El-Alfy, Abir T.

Phytochemistry Reviews, 2016 , vol. 15, # 6 p. 1035 - 1056 Title/Abstract Full Text Show Details

Abad; Camarasa; Pubill; Camins; Escubedo

Molecular Neurobiology, 2016 , vol. 53, # 10 p. 7271 - 7283 Title/Abstract Full Text Show Details

Zack, Martin; Cho, Sang Soo; Parlee, Jennifer; Jacobs, Mark; Li, Crystal; Boileau, Isabelle; Strafella, Antonio

Brain Stimulation, 2016 , vol. 9, # 6 p. 867 - 875 Title/Abstract Full Text Show Details

MacLaren, Duncan A. A.; Browne, Richard W.; Shaw, Jessica K.; Radhakrishnan, Sandhya Krishnan; Khare, Prachi; España, Rodrigo A.; Clark, Stewart D.

eNeuro, 2016 , vol. 3, # 5 art. no. E0219-16.2016 Title/Abstract Full Text Show Details

Comment (Pharmacological Data)

Bioactivities present

Reference

Robbins

Journal of Psychopharmacology, 2016 , vol. 30, # 11 p. 1082 - 1089


Title/Abstract Full Text Show Details

Pintsuk, Julia; Borroto-Escuela, Dasiel O.; Lai, Terence K.Y.; Liu, Fang; Fuxe, Kjell

Life Sciences, 2016 , vol. 167, p. 92 - 97 Title/Abstract Full Text Show Details

Beaulieu, Jean-Martin

Journal of Neurochemistry, 2016 , vol. 139, # 4 p. 520 - 522 Title/Abstract Full Text Show Details

Can, Adem; Frost, Douglas O.; Cachope, Roger; Cheer, Joseph F.; Gould, Todd D.

Journal of Neurochemistry, 2016 , vol. 139, # 4 p. 576 - 585 Title/Abstract Full Text Show Details

Betzler; Heinz; Köhler

Fortschritte der Neurologie Psychiatrie, 2016 , vol. 84, # 11 p. 690 - 698 Title/Abstract Full Text Show Details

Berning, Moritz; Hardon, Anita

Contemporary Drug Problems, 2016 , vol. 43, # 3 p. 277 - 292 Title/Abstract Full Text Show Details

Hupli, Aleksi; Didžiokaitė, Gabija; Ydema, Marte

Contemporary Drug Problems, 2016 , vol. 43, # 3 p. 242 - 257 Title/Abstract Full Text Show Details

Mandler, Tait

Contemporary Drug Problems, 2016 , vol. 43, # 3 p. 258 - 276 Title/Abstract Full Text Show Details

Le Garff, Erwan; Tournel, Gilles; Becquart, Coralie; Cottencin, Olivier; Dupin, Nicolas; Delaporte, Emmanuel; Hedouin, Valéry

Journal of Forensic Sciences, 2016 , vol. 61, # 6 p. 1681 - 1685 Title/Abstract Full Text Show Details

Gururajan, Anand; Malone, Daniel Thomas

Schizophrenia Research, 2016 , vol. 176, # 2-3 p. 281 - 290 Title/Abstract Full Text Show Details

Egerton, Alice; Valmaggia, Lucia R.; Howes, Oliver D.; Day, Fern; Chaddock, Christopher A.; Allen, Paul; Winton-Brown, Toby T.; Bloomfield, Michael A.P.; Bhattacharyya, Sagnik; Chilcott, Jack; Lappin, Julia M.; Murray, Robin M.; McGuire, Philip

Schizophrenia Research, 2016 , vol. 176, # 2-3 p. 171 - 176 Title/Abstract Full Text Show Details

Bluth, Martin H.; Pincus, Matthew R.

Clinics in Laboratory Medicine, 2016 , vol. 36, # 4 p. 603 - 634 Title/Abstract Full Text Show Details

Alcamán, Katherinne; Duffau, Boris Ettienne; Morales, Daniela

Journal of Planar Chromatography - Modern TLC, 2016 , vol. 29, # 6 p. 474 - 476 Title/Abstract Full Text Show Details

Jansone, Baiba; Kuum, Malle; Maciulaitis, Romaldas

Pharmacological Research, 2016 , vol. 113, p. 721 - 722 Title/Abstract Full Text Show Details

Zhang, Yan Victoria; Wei, Bin; Zhu, Yu; Zhang, Yanhua; Bluth, Martin H.

Clinics in Laboratory Medicine, 2016 , vol. 36, # 4 p. 635 - 661 Title/Abstract Full Text Show Details

Motaghinejad, Majid; Motevalian, Manijeh; Falak, Reza; Heidari, Mansour; Sharzad, Mahshid; Kalantari, Elham

Journal of Neural Transmission, 2016 , vol. 123, # 12 p. 1463 - 1477 Title/Abstract Full Text Show Details

Krishnan, Archana; Brown, Shan-Estelle; Ghani, Mansur A.; Khan, Farrah; Kamarulzaman, Adeeba; Altice, Frederick L.

Substance Abuse, 2016 , vol. 37, # 4 p. 542 - 549 Title/Abstract Full Text Show Details

Karlstad, Øystein; Zoëga, Helga; Furu, Kari; Bahmanyar, Shahram; Martikainen, Jaana E; Kieler, Helle; Pottegård, Anton

European Journal of Clinical Pharmacology, 2016 , vol. 72, # 12 p. 1507 - 1514 Title/Abstract Full Text Show Details

Li, Peng; Snyder, Gretchen L.; Vanover, Kimberly E.

Current Topics in Medicinal Chemistry, 2016 , vol. 16, # 29 p. 3385 - 3403 Title/Abstract Full Text Show Details

Sharma, Kanchan; Davis, Thomas; Coulthard, Elizabeth

Translational Neuroscience, 2016 , vol. 7, # 1 p. 98 - 109 Title/Abstract Full Text Show Details

77 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Storholm, Erik David; Silverberg, Michael J.; Satre, Derek D.

Journal of Psychoactive Drugs, 2016 , vol. 48, # 5 p. 377 - 383 Title/Abstract Full Text Show Details

Shimomura, Eric T.; Briones, Alice J.; Warren, Wendy S.; Addison, Joseph W.; Knittel, Jessica L.; Shoemaker, Sarah A.; King, Taj D.; Bosy, Thomas Z.

Journal of Analytical Toxicology, 2016 , vol. 40, # 7 art. no. BKW045, p. 543 - 545 Title/Abstract Full Text Show Details

Busardò, Francesco P.; Pichini, Simona; Pacifici, Roberta; Karch, Steven B.

Journal of Analytical Toxicology, 2016 , vol. 40, # 7 art. no. BKW051, p. 561 - 562 Title/Abstract Full Text Show Details

Casolin, Armand

Journal of Analytical Toxicology, 2016 , vol. 40, # 7 art. no. BKW055, p. 479 - 485 Title/Abstract Full Text Show Details

Bakota, Erica; Arndt, Crystal; Romoser, Amelia A.; Wilson, Stephen K.

Journal of Analytical Toxicology, 2016 , vol. 40, # 7 art. no. BKW056, p. 504 - 510 Title/Abstract Full Text Show Details

Jamey, Carole; Kintz, Pascal; Martrille, Laurent; Raul, Jean-Sébastien

Journal of Analytical Toxicology, 2016 , vol. 40, # 7 art. no. BKW058, p. 546 - 552 Title/Abstract Full Text Show Details

Skov, Louise; Holm, Karen Marie Dollerup; Johansen, Sys Stybe; Linnet, Kristian

Journal of Analytical Toxicology, 2016 , vol. 40, # 7 art. no. BKW059, p. 529 - 536


Title/Abstract Full Text Show Details

Nieddu, Maria; Burrai, Lucia; Baralla, Elena; Pasciu, Valeria; Varoni, Maria Vittoria; Briguglio, Irene; Demontis, Maria Piera; Boatto, Gianpiero

Journal of Analytical Toxicology, 2016 , vol. 40, # 7 art. no. BKW060, p. 492 - 497 Title/Abstract Full Text Show Details

Smith; Cole; Hamilton; West; Morley; Maskell

Journal of Analytical Toxicology, 2016 , vol. 40, # 7 art. no. BKW061, p. 553 - 560 Title/Abstract Full Text Show Details

Bhatt, Meha; Zielinski, Laura; Baker-Beal, Lola; Bhatnagar, Neera; Mouravska, Natalia; Laplante, Phillip; Worster, Andrew; Thabane, Lehana; Samaan, Zainab

Systematic Reviews, 2016 , vol. 5, # 1 art. no. 189 Title/Abstract Full Text Show Details

Reece, Albert Stuart; Norman, Amanda; Hulse, Gary Kenneth

BMJ Open, 2016 , vol. 6, # 11 art. no. E011891 Title/Abstract Full Text Show Details

Kim, Eunmi; Park, Yonghoon; Ha, Hongil; Chung, Heesun

Forensic Science International, 2016 , vol. 269, p. 50 - 55 Title/Abstract Full Text Show Details

Thurtle, Natalie; Dargan, Paul I; Hunter, Laura J; Lovett, Caitlyn; White, John A; Wood, David M

International Journal of STD and AIDS, 2016 , vol. 27, # 14 p. 1309 - 1316 Title/Abstract Full Text Show Details

Khare, Manasi; Suprabha, Baranya Shrikrishna; Rao, Arathi

International Journal of Clinical Dentistry, 2016 , vol. 9, # 3 p. 205 - 212 Title/Abstract Full Text Show Details

Shahani, Neelam; Swarnkar, Supriya; Giovinazzo, Vincenzo; Morgenweck, Jenny; Bohn, Laura M.; Scharager-Tapia, Catherina; Pascal, Bruce; Martinez-Acedo, Pablo; Khare, Kshitij; Subramaniam, Srinivasa

Science Signaling, 2016 , vol. 9, # 454 art. no. RA111 Title/Abstract Full Text Show Details

Konieczny, Jolanta; Czarnecka, Anna; Lenda, Tomasz; Kamińska, Kinga; Antkiewicz-Michaluk, Lucyna

Neuroscience, 2017 , vol. 340, p. 308 - 318 Title/Abstract Full Text Show Details

Bloomfield, Michael A. P.; Ashok, Abhishekh H.; Volkow, Nora D.; Howes, Oliver D.

Nature, 2016 , vol. 539, # 7629 p. 369 - 377 Title/Abstract Full Text Show Details

Colby, Donn; Nguyen, Ngoc Anh; Le, Bao; Toan, Trang; Thien, Dinh Duc; Huyen, Hoang Thi; Mai, Thi Doan Anh; Friedman, Mackey R.; Stall, Ron

AIDS and Behavior, 2016 , vol. 20, p. 379 - 385 Title/Abstract Full Text Show Details

UNIVERSITY OF KANSAS; UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.; GOLDEN, Jennifer E.; CHUNG, Donghoon

Patent: WO2016/183093 A1, 2016 ; Title/Abstract Full Text Show Details

Paul, Michael J.; Chisolm, Margaret S.; Johnson, Matthew W.; Vandrey, Ryan G.; Dredze, Mark

Journal of Addiction Medicine, 2016 , vol. 10, # 5 p. 324 - 330 Title/Abstract Full Text Show Details

78 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

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ACS Chemical Neuroscience, 2016 , vol. 7, # 11 p. 1508 - 1518 Title/Abstract Full Text Show Details

Vonder Haar, Cole; Lam, Frederick C.W.; Adams, Wendy K.; Riparip, Lara-Kirstie; Kaur, Sukhbir; Muthukrishna, Michael; Rosi, Susanna; Winstanley, Catharine A.

ACS Chemical Neuroscience, 2016 , vol. 7, # 11 p. 1531 - 1542 Title/Abstract Full Text Show Details

Pucci, Mark

Adverse Drug Reaction Bulletin, 2016 , vol. 299, # 1 p. 1155 - 1158 Title/Abstract Full Text Show Details

Fisher, Dennis G.; Reynolds, Grace L.; D'Anna, Laura H.; Hosmer, David W.; Hardan-Khalil, Kholoud

Journal of Substance Abuse Treatment, 2017 , vol. 73, p. 55 - 62 Title/Abstract Full Text Show Details

Berihu, Birhane Alem; Asfeha, Gebrekidan Gebregzabher; Welderufael, Abadi L.; Debeb, Yared Godefa; Zelelow, Yibrah Berhe; Beyene, Hafte Assefa

Journal of Neurosciences in Rural Practice, 2017 , vol. 8, # 1 p. 30 - 37 Title/Abstract Full Text Show Details

Todd, Gabrielle; Pearson-Dennett, Verity; Wilcox, Robert A.; Chau, Minh T.; Thoirs, Kerry; Thewlis, Dominic; Vogel, Adam P.; White, Jason M.

Parkinsonism and Related Disorders, 2016 , vol. 25, p. 27 - 32 Title/Abstract Full Text Show Details

Muceniece, Ruta; Namniece, Jana; Nakurte, Ilva; Jekabsons, Kaspars; Riekstina, Una; Jansone, Baiba

Pharmacological Research, 2016 , vol. 113, p. 760 - 770 Title/Abstract Full Text Show Details

O'Leary, Aet; Kõiv, Kadri; Raudkivi, Karita; Harro, Jaanus

Pharmacological Research, 2016 , vol. 113, p. 739 - 746 Title/Abstract Full Text Show Details

Kumsar; Dilbaz

Andrologia, 2016 , vol. 48, # 10 p. 1229 - 1235 Title/Abstract Full Text Show Details

Baracz, Sarah J.; Cornish, Jennifer L.

Frontiers in Neuroendocrinology, 2016 , vol. 43, p. 1 - 18 Title/Abstract Full Text Show Details

Pavlović, Dražen; Kimmins, Scott; Mutak, Stjepan

European Journal of Medicinal Chemistry, 2017 , vol. 125, p. 210 - 224


Title/Abstract Full Text Show Details

Maia, Tiago V.; Frank, Michael J.

Biological Psychiatry, 2017 , vol. 81, # 1 p. 52 - 66 Title/Abstract Full Text Show Details

Chuhma, Nao; Mingote, Susana; Kalmbach, Abigail; Yetnikoff, Leora; Rayport, Stephen

Biological Psychiatry, 2017 , vol. 81, # 1 p. 43 - 51 Title/Abstract Full Text Show Details

Howes, Oliver D.; McCutcheon, Robert; Owen, Michael J.; Murray, Robin M.

Biological Psychiatry, 2017 , vol. 81, # 1 p. 9 - 20 Title/Abstract Full Text Show Details

Urs, Nikhil M.; Peterson, Sean M.; Caron, Marc G.

Biological Psychiatry, 2017 , vol. 81, # 1 p. 78 - 85 Title/Abstract Full Text Show Details

Schmidt, Thomas P.; Pennington, David L.; Cardoos, Stephanie L.; Durazzo, Timothy C.; Meyerhoff, Dieter J.

Journal of Clinical and Experimental Neuropsychology, 2017 , vol. 39, # 1 p. 22 - 34 Title/Abstract Full Text Show Details

Vahabzadeh, Maryam; Toussi, Alireza Ghassemi

Asia Pacific Journal of Medical Toxicology, 2016 , vol. 5, # 1 p. 32 - 34 Title/Abstract Full Text Show Details

Pineo, Caleb Evans; Pineo, Thomas Zeitler

BMJ Case Reports, 2016 , vol. 2016, art. no. 216138 Title/Abstract Full Text Show Details

Marchese; Paz; Caeiro; Dadam; Baiardi; Perez; Bregonzio

Neuroscience, 2017 , vol. 340, p. 521 - 529 Title/Abstract Full Text Show Details

CUREMARK, LLC; Fallon, Joan M.; Heil, Matthew; Szigethy, James; Fallon, James

Patent: US9492515 B2, 2016 ; Title/Abstract Full Text Show Details

79 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

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Neuropharmacology, 2017 , vol. 114, p. 48 - 57 Title/Abstract Full Text Show Details

Beheshti, Siamak; Zeinali, Reyhaneh; Esmaeili, Abolghasem

Behavioural Brain Research, 2017 , vol. 320, p. 85 - 90 Title/Abstract Full Text Show Details

Gracia-Lor, Emma; Zuccato, Ettore; Castiglioni, Sara

Science of the Total Environment, 2016 , vol. 573, p. 1648 - 1659 Title/Abstract Full Text Show Details

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Cicero, Theodore J.; Ellis, Matthew S.; Kasper, Zachary A.

Addictive Behaviors, 2017 , vol. 65, p. 242 - 244 Title/Abstract Full Text Show Details

Balakrishna, Keshava; Rath, Amlan; Praveenkumarreddy, Yerabham; Guruge, Keerthi Siri; Subedi, Bikram

Ecotoxicology and Environmental Safety, 2017 , vol. 137, p. 113 - 120 Title/Abstract Full Text Show Details

Kinyua, Juliet; Negreira, Noelia; Miserez, Bram; Causanilles, Ana; Emke, Erik; Gremeaux, Lies; de Voogt, Pim; Ramsey, John; Covaci, Adrian; van Nuijs, Alexander L.N.

Science of the Total Environment, 2016 , vol. 573, p. 1527 - 1535 Title/Abstract Full Text Show Details

Wood, Kelly E.; Krasowski, Matthew D.

Journal of Medical Toxicology, 2016 , vol. 12, # 4 p. 402 - 405 Title/Abstract Full Text Show Details

Felger, Jennifer C.; Treadway, Michael T.

Neuropsychopharmacology, 2017 , vol. 42, # 1 p. 216 - 241 Title/Abstract Full Text Show Details

Bashiri; Vessally; Bekhradnia; Hosseinian; Edjlali

Vacuum, 2017 , vol. 136, p. 156 - 162 Title/Abstract Full Text Show Details

Bodnar Willard, Melissa A.; McGuffin, Victoria L.; Smith, Ruth Waddell

Forensic Science International, 2017 , vol. 270, p. 111 - 120 Title/Abstract Full Text Show Details

Leyton, Marco

Current Opinion in Behavioral Sciences, 2017 , vol. 13, p. 130 - 138 Title/Abstract Full Text Show Details

Dos Santos, Rafael G.; Balthazar, Fermanda M.; Bouso, José C.; Hallak, Jaime E.C.

Journal of Psychopharmacology, 2016 , vol. 30, # 12 p. 1230 - 1247 Title/Abstract Full Text Show Details

Bershad, Anya K.; Miller, Melissa A.; Baggott, Matthew J.; De Wit, Harriet

Journal of Psychopharmacology, 2016 , vol. 30, # 12 p. 1248 - 1258 Title/Abstract Full Text Show Details

Schänzer, Wilhelm; Thevis, Mario

Mass Spectrometry Reviews, 2017 , vol. 36, # 1 p. 16 - 46 Title/Abstract Full Text Show Details

Koskela, Maryna; Bäck, Susanne; Võikar, Vootele; Richie, Christopher T.; Domanskyi, Andrii; Harvey, Brandon K.; Airavaara, Mikko

Neurobiology of Disease, 2017 , vol. 97, p. 189 - 200 Title/Abstract Full Text Show Details

Palamar, Joseph J.; Acosta, Patricia; Ompad, Danielle C.; Cleland, Charles M.

Substance Use and Misuse, 2017 , vol. 52, # 1 p. 82 - 91


Title/Abstract Full Text Show Details

Boles, Tammy H.; Wells, Martha J. M.

Electrophoresis, 2016 , vol. 37, # 23-24 p. 3101 - 3108 Title/Abstract Full Text Show Details

Tai, Sherlock; Morrison, Calum

TrAC - Trends in Analytical Chemistry, 2017 , vol. 86, p. 251 - 262 Title/Abstract Full Text Show Details

Goulding, David R.; White, Sally S.; McBride, Sandra J.; Fenton, Suzanne E.; Harry, G. Jean

NeuroToxicology, 2017 , vol. 58, p. 110 - 119 Title/Abstract Full Text Show Details

80 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

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Journal of Psychopharmacology, 2016 , vol. 30, # 12 p. 1296 - 1304 Title/Abstract Full Text Show Details

Won, So-Yoon; Park, Mee-Hee; You, Soon-Tae; Choi, Seung-Won; Kim, Hyong-Kyu; McLean, Catriona; Bae, Suk-Chul; Kim, Sang Ryong; Jin, Byung Kwan; Lee, Kun Ho; Shin, Eun-Young; Kim, Eung-Gook

Science Translational Medicine, 2016 , vol. 8, # 367 art. no. 367RA170 Title/Abstract Full Text Show Details

Krumbiegel, Franziska; Hastedt, Martin; Westendorf, Lena; Niebel, André; Methling, Maximilian; Parr, Maria Kristina; Tsokos, Michael

Forensic Science, Medicine, and Pathology, 2016 , vol. 12, # 4 p. 416 - 434 Title/Abstract Full Text Show Details

Reed, Stephanie Collins; Izenwasser, Sari

Brain Research, 2017 , vol. 1654, p. 165 - 170 Title/Abstract Full Text Show Details

Sade; Toker; Kara; Einat; Rapoport; Moechars; Berry; Bersudsky; Agam

Translational Psychiatry, 2016 , vol. 6, # 12 art. no. E968 Title/Abstract Full Text Show Details

Gatica, Rafael Ignacio; Pérez-Valenzuela, Enzo; Sierra-Mercado, Demetrio; Fuentealba, José Antonio

Neuroscience Letters, 2017 , vol. 638, p. 21 - 26 Title/Abstract Full Text Show Details

Magni, Stefano; Parolini, Marco; Della Torre, Camilla; de Oliveira, Luciana Fernandes; Catani, Martina; Guzzinati, Roberta; Cavazzini, Alberto; Binelli, Andrea

Science of the Total Environment, 2017 , vol. 578, p. 452 - 459 Title/Abstract Full Text Show Details

Stoykova, Silviya; Kanev, Kamen; Pantcheva, Ivayla; Atanasov, Vasil

Analytical Letters, 2016 , vol. 49, # 17 p. 2822 - 2832 Title/Abstract Full Text Show Details

Gao, Tingting; Du, Peng; Xu, Zeqiong; Li, Xiqing

Science of the Total Environment, 2017 , vol. 575, p. 963 - 969 Title/Abstract Full Text Show Details

Pitts, Raymond C.; Cummings, Craig W.; Cummings, Carol; Woodcock, Rebecca L.; Hughes, Christine E.

Experimental and Clinical Psychopharmacology, 2016 , vol. 24, # 6 p. 464 - 476 Title/Abstract Full Text Show Details

Letourneau, Elizabeth J.; McCart, Michael R.; Sheidow, Ashli J.; Mauro, Pia M.

Journal of Substance Abuse Treatment, 2017 , vol. 72, p. 56 - 65 Title/Abstract Full Text Show Details

Mascolo; Sessa; Scavone; De Angelis; Vitale; Berrino; Rossi; Rosano; Capuano

International Journal of Cardiology, 2017 , vol. 227, p. 734 - 742 Title/Abstract Full Text Show Details

Tarján, Anna; Dudás, Mária; Wiessing, Lucas; Horváth, Gergely; Rusvai, Erzsébet; Tresó, Bálint; Csohán, Ágnes

International Journal of Drug Policy, 2017 , vol. 41, p. 1 - 7 Title/Abstract Full Text Show Details

Alharbi, Fares F.; El-Guebaly, Nady

Addictive Disorders and their Treatment, 2016 , vol. 15, # 4 p. 190 - 200 Title/Abstract Full Text Show Details

Garcia, Erik J.; Jorgensen, Emily T.; Sprick, Lukas S.; Cain, Mary E.

Behavioural Brain Research, 2017 , vol. 320, p. 186 - 194 Title/Abstract Full Text Show Details

Urs, Nikhil M.; Gee, Steven M.; Pack, Thomas F.; McCorvy, John D.; Evron, Tama; Snyder, Joshua C.; Yang, Xiaobao; Rodriguiz, Ramona M.; Borrelli, Emiliana; Wetsel, William C.; Jin, Jian; Roth, Bryan L.; O'Donnell, Patricio; Caron, Marc G.; Snyder, Solomon H.

Proceedings of the National Academy of Sciences of the United States of America, 2016 , vol. 113, # 50 p. E8178 - E8186 Title/Abstract Full Text Show Details

Fox, Megan E.; Wightman, R. Mark

Pharmacological Reviews, 2017 , vol. 69, # 1 p. 12 - 32 Title/Abstract Full Text Show Details

Slifstein, Mark; Abi-Dargham, Anissa

Seminars in Nuclear Medicine, 2017 , vol. 47, # 1 p. 54 - 63 Title/Abstract Full Text Show Details

RUGEN HOLDINGS (CAYMAN) LIMITED; SHAPIRO, Gideon

Patent: WO2016/196513 A1, 2016 ; Title/Abstract Full Text Show Details

Anniss, Angela M.; Young, Alan; O'Driscoll, Denise M.

Journal of Clinical Sleep Medicine, 2016 , vol. 12, # 12 p. 1633 - 1640 Title/Abstract Full Text Show Details

81 of 317

Comment (Pharmacological

Bioactivities present


Data)

82 of 317

Reference

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Forensic Chemistry, 2016 , vol. 1, p. 66 - 73 Title/Abstract Full Text Show Details

Van De Giessen; Weinstein; Cassidy; Haney; Dong; Ghazzaoui; Ojeil; Kegeles; Xu; Vadhan; Volkow; Slifstein; Abi-Dargham

Molecular Psychiatry, 2017 , vol. 22, # 1 p. 68 - 75 Title/Abstract Full Text Show Details

Kakish, Joe; Allen, Kevin J. H.; Harkness, Troy A.; Krol, Ed S.; Lee, Jeremy S.

ACS Chemical Neuroscience, 2016 , vol. 7, # 12 p. 1671 - 1680 Title/Abstract Full Text Show Details

Hon, Kam L.; Chan, Michael H. M.; Ng, Ming H. J.; Ho, Chi C.; Tsang, Kathy Y. C.; Tam, Wing H.; Ho, Chung S.

Current Clinical Pharmacology, 2016 , vol. 11, # 4 p. 274 - 281 Title/Abstract Full Text Show Details

Birkholm, Klavs

Hyle, 2016 , vol. 22, # 1 p. 127 - 148 Title/Abstract Full Text Show Details

Bade, Richard; Plósz, Benedek G.; Baz-Lomba, Jose A.; Castiglioni, Sara; Castrignanò, Erika; Causanilles, Ana; de Voogt, Pim; Kinyua, Juliet; McCall, Ann-Kathrin; Bijlsma, Lubertus; Ramin, Pedram; Ryu, Yeonsuk; Gracia-Lor, Emma; KasprzykHordern, Barbara; van Nuijs, Alexander L.N.; Ort, Christoph; Sancho, Juan V.; Thomas, Kevin V.; Rousis, Nikolaos I.; Zuccato, Ettore; Hernández, Félix

Chemosphere, 2017 , vol. 168, p. 1032 - 1041 Title/Abstract Full Text Show Details

Kimani; Patel; Kioy

Metabolic Brain Disease, 2016 , vol. 31, # 1 p. 45 - 52 Title/Abstract Full Text Show Details

Majdak, Petra; Ossyra, John R.; Ossyra, Jessica M.; Cobert, Adam J.; Hofmann, Gabrielle C.; Tse, Stephen; Panozzo, Brent; Grogan, Elizabeth L.; Sorokina, Anastassia; Rhodes, Justin S.

Scientific Reports, 2016 , vol. 6, art. no. 39472 Title/Abstract Full Text Show Details

Carson, Mariah; Kerrigan, Sarah

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2017 , vol. 1040, p. 289 - 294 Title/Abstract Full Text Show Details

Sarker, Abeed; O’Connor, Karen; Ginn, Rachel; Scotch, Matthew; Smith, Karen; Malone, Dan; Gonzalez, Graciela

Drug Safety, 2016 , vol. 39, # 3 p. 231 - 240 Title/Abstract Full Text Show Details

Tsartsalis, Stergios; Tournier, Benjamin B.; Aoun, Karl; Habiby, Selim; Pandolfo, Diego; Dimiziani, Andrea; Ginovart, Nathalie; Millet, Philippe

NeuroImage, 2017 , vol. 147, p. 461 - 472 Title/Abstract Full Text Show Details

Sahai, Michelle A.; Davidson, Colin; Khelashvili, George; Barrese, Vincenzo; Dutta, Neelakshi; Weinstein, Harel; OpackaJuffry, Jolanta

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2017 , vol. 75, p. 1 - 9 Title/Abstract Full Text Show Details

Coopman, Vera; Cordonnier, Jan; De Leeuw, Marc; Cirimele, Vincent

Forensic Science International, 2016 , vol. 266, p. 469 - 473 Title/Abstract Full Text Show Details

Hirvioja, Jouni; Joutsa, Juho; Wahlsten, Pia; Korpela, Jaana

Oxford Medical Case Reports, 2016 , vol. 2016, # 3 p. 41 - 43 Title/Abstract Full Text Show Details

Cunha; Lopes; Fernandes

Journal of Food Composition and Analysis, 2017 , vol. 56, p. 147 - 155 Title/Abstract Full Text Show Details

Hearne, Evelyn; Grund, Jean-Paul Cornelius; Van Hout, Marie Claire; McVeigh, Jim

Harm Reduction Journal, 2016 , vol. 13, # 1 art. no. 14 Title/Abstract Full Text Show Details

Childress, Ann; Belchenko, Dmitry; Lempa, Brian

Expert Review of Neurotherapeutics, 2017 , vol. 17, # 2 p. 113 - 121 Title/Abstract Full Text Show Details

Traisman, Edward S.

Pediatric Annals, 2016 , vol. 45, # 12 p. e408 - e411 Title/Abstract Full Text Show Details

Kish, Stephen J.; Boileau, Isabelle; Callaghan, Russell C.; Tong, Junchao

European Journal of Neuroscience, 2017 , vol. 45, # 1 p. 58 - 66 Title/Abstract Full Text Show Details

Mereu, Maddalena; Chun, Lauren E.; Prisinzano, Thomas E.; Newman, Amy H.; Katz, Jonathan L.; Tanda, Gianluigi

European Journal of Neuroscience, 2017 , vol. 45, # 1 p. 167 - 174 Title/Abstract Full Text Show Details

Comment (Pharmacological Data)

Bioactivities present

Reference

Sokoloff, Pierre; Le Foll, Bernard

European Journal of Neuroscience, 2017 , vol. 45, # 1 p. 2 - 19 Title/Abstract Full Text Show Details

Smith, Douglas A.; Blough, Bruce E.; Banks, Matthew L.

Psychopharmacology, 2017 , vol. 234, # 1 p. 117 - 127 Title/Abstract Full Text Show Details

Cocker, Paul J.; Tremblay; Kaur; Winstanley, Catharine A.

Psychopharmacology, 2017 , vol. 234, # 1 p. 137 - 153 Title/Abstract Full Text Show Details

Best, Laura M.; Zhao, Leah L.; Scardochio, Tina; Clarke, Paul B.S.

Psychopharmacology, 2017 , vol. 234, # 1 p. 155 - 165 Title/Abstract Full Text Show Details

Benn, Abigail; Robinson, Emma S. J.


Psychopharmacology, 2017 , vol. 234, # 2 p. 255 - 266 Title/Abstract Full Text Show Details

Sauerzopf, Ulrich; Sacco, Roberto; Novarino, Gaia; Niello, Marco; Weidenauer, Ana; Praschak-Rieder, Nicole; Sitte, Harald; Willeit, Matthäus

European Journal of Neuroscience, 2017 , vol. 45, # 1 p. 45 - 57 Title/Abstract Full Text Show Details

Leventhal, Adam M.; Kirkpatrick, Matthew G.; Pester, Mollie S.; McGeary, John E.; Swift, Robert M.; Sussman, Steve; Kahler, Christopher W.

Psychopharmacology, 2017 , vol. 234, # 2 p. 307 - 315 Title/Abstract Full Text Show Details

Lohr, Kelly M.; Masoud, Shababa T.; Salahpour, Ali; Miller, Gary W.

European Journal of Neuroscience, 2017 , vol. 45, # 1 p. 20 - 33 Title/Abstract Full Text Show Details

Rise, Jostein; Halkjelsvik, Torleif; Kovač, Velibor Bobo

Contemporary Drug Problems, 2015 , vol. 42, # 4 p. 289 - 298 Title/Abstract Full Text Show Details

Kolar, Kat

Contemporary Drug Problems, 2015 , vol. 42, # 4 p. 314 - 330 Title/Abstract Full Text Show Details

Batt, Angela L.; Furlong, Edward T.; Mash, Heath E.; Glassmeyer, Susan T.; Kolpin, Dana W.

Science of the Total Environment, 2017 , vol. 579, p. 1618 - 1628 Title/Abstract Full Text Show Details

Pastor, Verónica; Antonelli, Marta Cristina; Pallarés, María Eugenia

Neurotoxicity Research, 2017 , vol. 31, # 1 p. 169 - 186 Title/Abstract Full Text Show Details

Bodnar, Richard J.

Peptides, 2017 , vol. 88, p. 126 - 188 Title/Abstract Full Text Show Details

Rognli, Eline Borger; Bramness, Jørgen G.; Skurtveit, Svetlana; Bukten, Anne

Journal of Substance Abuse Treatment, 2017 , vol. 74, p. 42 - 47 Title/Abstract Full Text Show Details

Budzynska, Barbara; Michalak, Agnieszka; Frankowska, Małgorzata; Kaszubska, Katarzyna; Biała, Grażyna

Pharmacological Reports, 2017 , vol. 69, # 2 p. 199 - 205 Title/Abstract Full Text Show Details

Prendergast, Michael L.; McCollister, Kathryn; Warda, Umme

Journal of Substance Abuse Treatment, 2017 , vol. 74, p. 54 - 64 Title/Abstract Full Text Show Details

Bahmanabadi; Akhgari; Jokar; Sadeghi

Human and Experimental Toxicology, 2017 , vol. 36, # 2 p. 195 - 202 Title/Abstract Full Text Show Details

Vicente-Rodríguez, Marta; Fernández-Calle, Rosalía; Gramage, Esther; Pérez-García, Carmen; Ramos, María P.; Herradón, Gonzalo

Mediators of Inflammation, 2016 , vol. 2016, art. no. 9894504 Title/Abstract Full Text Show Details

Mattingly, Gregory W.; Anderson, Richard H.

CNS Spectrums, 2016 , vol. 21, # S1 p. 48 - 58 Title/Abstract Full Text Show Details

Kim, Minjeong; Kim, Da Hye; Lee, Yong Sup; Jang, Choon-Gon; Yang, Chae Ha; Lee, Sooyeun

Forensic Toxicology, 2017 , vol. 35, # 1 p. 66 - 76 Title/Abstract Full Text Show Details

83 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Kubáň, Pavel; Hauser, Peter C.

Electrophoresis, 2017 , vol. 38, # 1 p. 95 - 114 Title/Abstract Full Text Show Details

Kuś, Piotr; Kusz, Joachim; Książek, Maria; Pieprzyca, Ewelina; Rojkiewicz, Marcin

Forensic Toxicology, 2017 , vol. 35, # 1 p. 114 - 124 Title/Abstract Full Text Show Details

Orsini, Caitlin A.; Mitchell, Marci R.; Heshmati, Sara C.; Shimp, Kristy G.; Spurrell, Megan S.; Bizon, Jennifer L.; Setlow, Barry Behavioural Brain Research, 2017 , vol. 321, p. 130 - 136 Title/Abstract Full Text Show Details

Liu, Philip K.; Liu, Christina H.

Journal of Biomedical Science, 2016 , vol. 23, # 1 art. no. 90 Title/Abstract Full Text Show Details

Taschwer, Magdalena; Grascher, Jörg; Schmid, Martin G.

Forensic Science International, 2017 , vol. 270, p. 232 - 240 Title/Abstract Full Text Show Details

Tung, Che-Se; Chang, Shang-Tang; Huang, Chuen-Lin; Huang, Nai-Kuei

Neuroscience Letters, 2017 , vol. 639, p. 185 - 191 Title/Abstract Full Text Show Details

Doran, Gregory S.; Deans, Ralph M.; De Filippis, Carlo; Kostakis, Chris; Howitt, Julia A.

Analytical Methods, 2017 , vol. 9, # 2 p. 198 - 210 Title/Abstract Full Text Show Details

Jafari Giv, Mahsa

Cardiovascular Toxicology, 2017 , vol. 17, # 1 p. 13 - 24 Title/Abstract Full Text Show Details

Nesbit, Maya O.; Dias, Carine; Phillips, Anthony G.

Behavioural Brain Research, 2017 , vol. 321, p. 223 - 231 Title/Abstract Full Text Show Details

Weiß, Jennifer A.; Kadkhodaei, Kian; Schmid, Martin G.

Science and Justice, 2017 , vol. 57, # 1 p. 6 - 12 Title/Abstract Full Text Show Details


Mardal, Marie; Kinyua, Juliet; Ramin, Pedram; Miserez, Bram; Van Nuijs, Alexander L. N.; Covaci, Adrian; Meyer, Markus R.

Drug Testing and Analysis, 2017 , vol. 9, # 1 p. 106 - 114 Title/Abstract Full Text Show Details

Bordin, Dayanne Mozaner; Bettim, Bárbara Beltrame; Perdona, Gleici Castro; de Campos, Eduardo Geraldo; De Martinis, Bruno Spinosa

Toxicology, 2017 , vol. 376, p. 75 - 82 Title/Abstract Full Text Show Details

Lendoiro, Elena; Jiménez-Morigosa, Cristian; Cruz, Angelines; Páramo, Mario; López-Rivadulla, Manuel; de Castro, Ana

Drug Testing and Analysis, 2017 , vol. 9, # 1 p. 96 - 105 Title/Abstract Full Text Show Details

Jakova, Elisabet; Lee, Jeremy S.

Electrophoresis, 2017 , vol. 38, # 2 p. 350 - 360 Title/Abstract Full Text Show Details

Zhang, Qian; Yang, Feng-Qing; Ge, Liya; Hu, Yuan-Jia; Xia, Zhi-Ning

Journal of Separation Science, 2017 , vol. 40, # 1 p. 49 - 80 Title/Abstract Full Text Show Details

Sánchez-Catalán, María-José; Faivre, Fanny; Yalcin, Ipek; Muller, Marc-Antoine; Massotte, Dominique; Majchrzak, Monique; Barrot, Michel

Neuropsychopharmacology, 2017 , vol. 42, # 3 p. 638 - 648 Title/Abstract Full Text Show Details

Elliott, Simon P.; Burke, Timothy; Smith, Christopher

Journal of Forensic Sciences, 2017 , vol. 62, # 1 p. 169 - 173 Title/Abstract Full Text Show Details

Chengdu Chester Technology Co., Ltd.; Peng, Fei

Patent: CN106083600 A, 2016 ; Title/Abstract Full Text Show Details

Canal, Clinton E.; Murnane, Kevin S.

Journal of Psychopharmacology, 2017 , vol. 31, # 1 p. 127 - 143 Title/Abstract Full Text Show Details

Patel, Neel; Ford, Loretta; Jones, Rachel; Bradberry, Sally M; Vale, J Allister

Clinical Toxicology, 2017 , vol. 55, # 2 p. 159 - 160 Title/Abstract Full Text Show Details

84 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Zack, Martin H.; Lobo, Daniela S.; Biback, Candice; Fang, Tim; Smart, Kelly; Tatone, Daniel; Kalia, Aditi; Digiacomo, Daniel; Kennedy, James L.

Journal of Psychopharmacology, 2017 , vol. 31, # 1 p. 31 - 42 Title/Abstract Full Text Show Details

Mahmud, Ashraf; Gallant, Stephanie; Sedki, Firas; D'Cunha, Tracey; Shalev, Uri

Journal of Psychopharmacology, 2017 , vol. 31, # 1 p. 96 - 104 Title/Abstract Full Text Show Details

Lehner, Małgorzata H.; Taracha, Ewa; Kaniuga, Ewelina; Wisłowska-Stanek, Aleksandra; Gryz, Marek; Sobolewska, Alicja; Turzyńska, Danuta; Skórzewska, Anna; PłaŁnik, Adam

Journal of Psychopharmacology, 2017 , vol. 31, # 1 p. 115 - 126 Title/Abstract Full Text Show Details

Yates, Justin R.; Rogers, Katherine K.; Gunkel, Benjamin T.; Prior, Nicholas A.; Hughes, Mallory N.; Sharpe, Sara M.; Campbell, Hunter L.; Johnson, Anthony B.; Keller, Margaret G.; Breitenstein, Kerry A.; Shults, Hansen N.

Behavioural Brain Research, 2017 , vol. 322, p. 29 - 33 Title/Abstract Full Text Show Details

Gremel; Lovinger

Genes, Brain and Behavior, 2017 , vol. 16, # 1 p. 71 - 85 Title/Abstract Full Text Show Details

Gillies, Glenda E.; Virdee, Kanwar; Pienaar, Ilse; Al-Zaid, Felwah; Dalley, Jeffrey W.

Brain Sciences, 2017 , vol. 7, # 1 art. no. 5 Title/Abstract Full Text Show Details

Ardani, Amir Rezaei; Saghebi, Seyyed Ali; Nahidi, Mahsa; Zeynalian, Farzaneh

Sleep Science, 2016 , vol. 9, # 3 p. 255 - 260 Title/Abstract Full Text Show Details

Fischbach, Peter

Cardiology in the Young, 2017 , vol. 27, # S1 p. S75 - S79 Title/Abstract Full Text Show Details

Østergaard, Jeanette; Østergaard, Stine V.; Fletcher, Adam

Contemporary Drug Problems, 2016 , vol. 43, # 4 p. 350 - 368 Title/Abstract Full Text Show Details

Tormoehlen, Laura M.; Blatsioris, Ashley D.; Moser, Elizabeth A.S.; Carter, Ravan J.L.; Stevenson, Alec; Ofner, Susan; Hulin, Abigail L.; O'Neill, Darren P.; Cohen-Gadol, Aaron A.; Leipzig, Thomas J.; Williams, Linda S.; Mackey, Jason

Neurology, 2017 , vol. 88, # 3 p. 252 - 258 Title/Abstract Full Text Show Details

Jørgensen, Louise M.; Weikop, Pia; Villadsen, Jonas; Visnapuu, Tanel; Ettrup, Anders; Hansen, Hanne D; Baandrup, Anders O; Andersen, Flemming L; Bjarkam, Carsten R; Thomsen, Carsten; Jespersen, Bo; Knudsen, Gitte M.

Journal of Cerebral Blood Flow and Metabolism, 2016 , vol. 37, # 2 p. 425 - 434 Title/Abstract Full Text Show Details

Momosaki, Sotaro; Ito, Miwa; Yamato, Hiroko; Iimori, Hitoshi; Sumiyoshi, Hirokazu; Morimoto, Kenji; Imamoto, Natsumi; Watabe, Tadashi; Shimosegawa, Eku; Hatazawa, Jun; Abe, Kohji

Journal of Cerebral Blood Flow and Metabolism, 2016 , vol. 37, # 2 p. 605 - 613 Title/Abstract Full Text Show Details

Motaghinejad, Majid; Motevalian, Manijeh; Shabab, Behnaz; Fatima, Sulail

Journal of Neural Transmission, 2017 , vol. 124, # 1 p. 121 - 131 Title/Abstract Full Text Show Details

Riederer, Peter; Müller, Thomas

Expert Opinion on Drug Metabolism and Toxicology, 2017 , vol. 13, # 2 p. 233 - 240 Title/Abstract Full Text Show Details


Almey, Anne; Arena, Lauren; Oliel, Joshua; Hafez, Nada; Mancinelli, Cynthia; Henning, Lukas; Tsanev, Aleks; Brake, Wayne G.

Hormones and Behavior, 2017 , vol. 89, p. 113 - 120 Title/Abstract Full Text Show Details

Garasic, Mirko D.; Lavazza, Andrea

BMC Medical Ethics, 2016 , vol. 17, # 1 art. no. 01601028 Title/Abstract Full Text Show Details

Philippu, Athineos

Current Medicinal Chemistry, 2016 , vol. 23, # 28 p. 2643 - 2652 Title/Abstract Full Text Show Details

Phillips, Ian R.; Shephard, Elizabeth A.

Expert Opinion on Drug Metabolism and Toxicology, 2017 , vol. 13, # 2 p. 167 - 181 Title/Abstract Full Text Show Details

Price, James W.

Journal of Addiction Medicine, 2016 , vol. 10, # 6 p. 414 - 417 Title/Abstract Full Text Show Details

Bajaj, Atul; John, Cijo; Kaur, Sukhminder; Middha, Deepak

Egyptian Journal of Forensic Sciences, 2016 , vol. 6, # 4 p. 538 - 541 Title/Abstract Full Text Show Details

85 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Garcia, Erik J.; Haddon, Tara N.; Saucier, Donald A.; Cain, Mary E.

Pharmacology Biochemistry and Behavior, 2017 , vol. 154, p. 20 - 30 Title/Abstract Full Text Show Details

Nakagawa, Yoshio; Suzuki, Toshinari; Tada, Yukie; Inomata, Akiko

Journal of Applied Toxicology, 2017 , vol. 37, # 3 p. 243 - 252 Title/Abstract Full Text Show Details

Köhler, Katharina M.; Hammer, Raija; Riedy, Kathrin; Auwärter, Volker; Neukamm, Merja A.

Journal of Clinical Laboratory Analysis, 2017 , vol. 31, # 1 art. no. E22021 Title/Abstract Full Text Show Details

Morana, Landhing M.; Phillipsa, Karran A.; Kowalczyka, William J.; Ghitzab, Udi E.; Agagea, Daniel A.; Epsteina, David H.; Prestona, Kenzie L.

Behavioural Pharmacology, 2017 , vol. 28, # 1 p. 63 - 73 Title/Abstract Full Text Show Details

Hädener, Marianne; Bruni, Pia S.; Weinmann, Wolfgang; Frübis, Matthias; König, Stefan

Analytical and Bioanalytical Chemistry, 2017 , vol. 409, # 5 p. 1291 - 1300 Title/Abstract Full Text Show Details

Narayanaswami, Vidya; Dwoskin, Linda P.

Pharmacology and Therapeutics, 2017 , vol. 170, p. 116 - 147 Title/Abstract Full Text Show Details

Alshagga, Mustafa Ahmed; Alshawsh, Mohammed Abdullah; Seyedan, Atefehalsadat; Alsalahi, Abdulsamad; Pan, Yan; Mohankumar, Suresh Kumar; Alkebsi, Abdolgodose; Kassim, Saba; Mohamed, Zahurin

Annals of Nutrition and Metabolism, 2017 , vol. 69, # 3-4 p. 200 - 211 Title/Abstract Full Text Show Details

Andra, Syam S.; Austin, Christine; Patel, Dhavalkumar; Dolios, Georgia; Awawda, Mahmoud; Arora, Manish

Environment International, 2017 , vol. 100, p. 32 - 61 Title/Abstract Full Text Show Details

Roberts, Liam; Ford, Loretta; Patel, Neel; Vale, J. Allister; Bradberry, Sally M.

Clinical Toxicology, 2017 , vol. 55, # 3 p. 181 - 186 Title/Abstract Full Text Show Details

Todd, Stephanie M.; Zhou, Cilla; Clarke, David J.; Chohan, Tariq W.; Bahceci, Dilara; Arnold, Jonathon C.

European Neuropsychopharmacology, 2017 , vol. 27, # 2 p. 132 - 145 Title/Abstract Full Text Show Details

Gracia-Lor, Emma; Castiglioni, Sara; Bade, Richard; Been, Frederic; Castrignanò, Erika; Covaci, Adrian; González-Mariño, Iria; Hapeshi, Evroula; Kasprzyk-Hordern, Barbara; Kinyua, Juliet; Lai, Foon Yin; Letzel, Thomas; Lopardo, Luigi; Meyer, Markus R.; O'Brien, Jake; Ramin, Pedram; Rousis, Nikolaos I.; Rydevik, Axel; Ryu, Yeonsuk; Santos, Miguel M.; Senta, Ivan; Thomaidis, Nikolaos S.; Veloutsou, Sofia; Yang, Zhugen; Zuccato, Ettore; Bijlsma, Lubertus

Environment International, 2017 , vol. 99, p. 131 - 150 Title/Abstract Full Text Show Details

Mowry, James B.; Spyker, Daniel A.; Brooks, Daniel E.; Zimmerman, Ashlea; Schauben, Jay L.

Clinical Toxicology, 2016 , vol. 54, # 10 p. 924 - 1109 Title/Abstract Full Text Show Details

Spiros, Athan; Roberts, Patrick; Geerts, Hugo

European Neuropsychopharmacology, 2017 , vol. 27, # 2 p. 107 - 119 Title/Abstract Full Text Show Details

Waddell; Fernandez; Inverarity; Prabhu

Sensing and Bio-Sensing Research, 2017 , vol. 13, p. 28 - 39 Title/Abstract Full Text Show Details

Gogos, Andrea; Kusljic, Snezana; Thwaites, Shane J.; van den Buuse, Maarten

Behavioural Brain Research, 2017 , vol. 322, p. 157 - 166 Title/Abstract Full Text Show Details

Müller, Thomas

Expert Opinion on Investigational Drugs, 2017 , vol. 26, # 2 p. 175 - 185 Title/Abstract Full Text Show Details

Verwey, Michael; Dhir, Sabine; Amir, Shimon

F1000Research, 2016 , vol. 5, art. no. 2062 Title/Abstract Full Text Show Details

YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.; UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL – UFRGS; UNIVERSIDADE DE SÃO PAULO - USP; MECHOULAM, Raphael; BREUER, Aviva; PEREIRA KAPCZINSKI, Flavio; DE SOUZA CRIPPA, Jose Alexandre; ZUARDI, Antonio Waldo; CECILIO HALLAK, Jaime Eduardo; SILVEIRA GUIMARAES, Francisco

Patent: WO2017/8136 A2, 2017 ;


Title/Abstract Full Text Show Details

Brunt, Tibor M.; Nagy, Constanze; Bücheli, Alexander; Martins, Daniel; Ugarte, Miren; Beduwe, Cécile; Ventura Vilamala, Mireia

Drug Testing and Analysis, 2017 , vol. 9, # 2 p. 188 - 198 Title/Abstract Full Text Show Details

Brandish, Emma K.; Owen, Christopher T.; Sinclair, Julia M.A.

Medicine (United Kingdom), 2017 , vol. 45, # 2 p. 68 - 73 Title/Abstract Full Text Show Details

86 of 317

87 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Petrie, Bruce; Smith, Benjamin D.; Youdan, Jane; Barden, Ruth; Kasprzyk-Hordern, Barbara

Analytica Chimica Acta, 2017 , vol. 959, p. 91 - 101 Title/Abstract Full Text Show Details

Patel, Mayur M.; Patel, Bhoomika M.

CNS Drugs, 2017 , vol. 31, # 2 p. 109 - 133 Title/Abstract Full Text Show Details

Amirav, Aviv

Chromatographia, 2017 , vol. 80, # 2 p. 295 - 300 Title/Abstract Full Text Show Details

Lambert, Mads Ødum; Ipsen, Theis Højland; Kohlmeier, Kristi Anne

Pharmacology Research and Perspectives, 2017 , vol. 5, # 1 art. no. E00282 Title/Abstract Full Text Show Details

Stokes, Robert J.; Bailey, Mike; Bonthron, Stuart; Stone, Thomas; Maskall, Guy; Presly, Oliver; Roy, Eric; Tombling, Craig; Loeffen, Paul W.

Proceedings of SPIE - The International Society for Optical Engineering, 2016 , vol. 9995, art. no. 999506 Title/Abstract Full Text Show Details

Mahmood, Danish

International Journal of Health Science, 2016 , vol. 10, # 4 p. 565 - 575 Title/Abstract Full Text Show Details

Yao, Hui; Rayburn, Elizabeth R.; Shi, Qiang; Gao, Liang; Hu, Wenjie; Li, Haibo

Critical Reviews in Clinical Laboratory Sciences, 2017 , vol. 54, # 1 p. 1 - 17 Title/Abstract Full Text Show Details

Krentz; Fujioka; Hompesch

Diabetes, Obesity and Metabolism, 2016 , vol. 18, # 6 p. 558 - 570 Title/Abstract Full Text Show Details

Meyers, Juliana; Gajria, Kavita; Candrilli, Sean D.; Fridman, Moshe; Sikirica, Vanja

Journal of Comparative Effectiveness Research, 2017 , vol. 6, # 2 p. 109 - 125 Title/Abstract Full Text Show Details

Comiran, Eloisa; Barreto, Fabiano; Meneghini, Leonardo Z.; Carlos, Graciela; Fröehlich, Pedro E.; Limberger, Renata Pereira

Biomedical Chromatography, 2017 , vol. 31, # 3 art. no. E3812 Title/Abstract Full Text Show Details

Ghadiri, Ameneh; Etemad, Leila; Moshiri, Mohammad; Moallem, Seyed Adel; Jafarian, Amir Hossein; Hadizadeh, Farzin; Seifi, Mahmoud

Iranian Journal of Basic Medical Sciences, 2017 , vol. 20, # 2 p. 138 - 144 Title/Abstract Full Text Show Details

Dinis-Oliveira, Ricardo Jorge

European Journal of Drug Metabolism and Pharmacokinetics, 2017 , vol. 42, # 1 p. 11 - 16 Title/Abstract Full Text Show Details

Lin, Zebin; Li, Jiaolun; Zhang, Xinyu; Qiu, Meihong; Huang, Zhibin; Rao, Yulan

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2017 , vol. 1046, p. 177 - 184 Title/Abstract Full Text Show Details

Caballero-Puntiverio, Maitane; Fitzpatrick, Ciarán Martin; Woldbye, David P.D.; Andreasen, Jesper Tobias

Journal of Psychopharmacology, 2017 , vol. 31, # 2 p. 272 - 283 Title/Abstract Full Text Show Details

Cross, Sarah J.; Lotfipour, Shahrdad; Leslie, Frances M.

American Journal of Drug and Alcohol Abuse, 2017 , vol. 43, # 2 p. 171 - 185 Title/Abstract Full Text Show Details

Kohut, Stephen J.

American Journal of Drug and Alcohol Abuse, 2017 , vol. 43, # 2 p. 155 - 170 Title/Abstract Full Text Show Details

Ford, Loretta T; Berg, Jonathan D

Annals of Clinical Biochemistry, 2017 , vol. 54, # 2 p. 219 - 229 Title/Abstract Full Text Show Details

Ruzza, Chiara; Calò, Girolamo; Di Maro, Salvatore; Pacifico, Salvatore; Trapella, Claudio; Salvadori, Severo; Preti, Delia; Guerrini, Remo

Expert Opinion on Therapeutic Patents, 2017 , vol. 27, # 3 p. 347 - 362 Title/Abstract Full Text Show Details

Wong, Scott A.; Thapa, Raj; Badenhorst, Cecilia A.; Briggs, Alicia R.; Sawada, Justan A.; Gruber, Aaron J.

Neuroscience, 2017 , vol. 345, p. 218 - 228 Title/Abstract Full Text Show Details

Bailey, Matthew R.; Simpson, Eleanor H.; Balsam, Peter D.

Neurobiology of Learning and Memory, 2016 , vol. 133, p. 233 - 256 Title/Abstract Full Text Show Details

Comment (Pharmacological Data)

Bioactivities present

Reference

Dunn, Matthew

International Journal of Drug Policy, 2017 , vol. 40, p. 26 - 34 Title/Abstract Full Text Show Details

Riley, Elise D.; Hsue, Priscilla Y.; Vittinghoff, Eric; Wu, Alan H.B.; Coffin, Phillip O.; Moore, Peter K.; Lynch, Kara L.


Drug and Alcohol Dependence, 2017 , vol. 172, p. 88 - 93 Title/Abstract Full Text Show Details

Barkhuizen; van den Hove; Vles; Steinbusch; Kramer; Gavilanes

Neuroscience and Biobehavioral Reviews, 2017 , vol. 75, p. 166 - 182 Title/Abstract Full Text Show Details

Kopra, Jaakko J.; Panhelainen, Anne; af Bjerkén, Sara; Porokuokka, Lauriina L.; Varendi, Kärt; Olfat, Soophie; Montonen, Heidi; Piepponen, T. Petteri; Saarma, Mart; Andressoo, Jaan-Olle

Journal of Neuroscience, 2017 , vol. 37, # 6 p. 1581 - 1590 Title/Abstract Full Text Show Details

Abiedalla, Younis; DeRuiter, Jack; Clark, C. Randall

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2017 , vol. 1048, p. 38 - 48 Title/Abstract Full Text Show Details

Feio-Azevedo; Costa; Ferreira; Branco; Pereira; Bastos; Carvalho; Capela

Toxicology Letters, 2017 , vol. 269, p. 65 - 76 Title/Abstract Full Text Show Details

Weidenauer, Ana; Bauer, Martin; Sauerzopf, Ulrich; Bartova, Lucie; Praschak-Rieder, Nicole; Sitte, Harald H.; Kasper, Siegfried; Willeit, Matthäus

International Journal of Neuropsychopharmacology, 2017 , vol. 20, # 1 Title/Abstract Full Text Show Details

Atabay, Ender; Rodopman Arman, Ayşe

Marmara Medical Journal, 2016 , vol. 29, # 3 p. 177 - 180 Title/Abstract Full Text Show Details

Fields, Scott A.; Johnson, William Michael; Hassig, Madison B.

Journal of Family Practice, 2017 , vol. 66, # 2 p. 68 - 74 Title/Abstract Full Text Show Details

Wijers, Charlotte H W; van Litsenburg, Ronald T H; Hondebrink, Laura; Niesink, Raymond J M; Croes, Esther A

The Lancet, 2017 , vol. 389, # 10069 p. 600 - 600 Title/Abstract Full Text Show Details

Smith, Tess E.; Martel, Michelle M.; DeSantis, Alan D.

Substance Use and Misuse, 2017 , vol. 52, # 4 p. 548 - 552 Title/Abstract Full Text Show Details

Akhgari, Maryam; Mobaraki, Homeira; Etemadi-Aleagha, Afshar

DARU, Journal of Pharmaceutical Sciences, 2017 , vol. 25, # 1 art. no. 5 Title/Abstract Full Text Show Details

Fletcher, Paul J.; Zeeb, Fiona D.; Browne, Caleb J.; Higgins, Guy A.; Soko, Ashlie D.

Psychopharmacology, 2017 , vol. 234, # 5 p. 889 - 902 Title/Abstract Full Text Show Details

Rendon, Alexis; Livingston, Melvin; Suzuki, Sumihiro; Hill, Whitney; Walters, Scott

Addictive Behaviors, 2017 , vol. 70, p. 90 - 96 Title/Abstract Full Text Show Details

Mansukhani, Meghna P.; Kolla, Bhanu Prakash; Park, John G.

Sleep Medicine, 2017 , vol. 32, p. 171 - 175 Title/Abstract Full Text Show Details

Becker, Jill B.

Dialogues in Clinical Neuroscience, 2016 , vol. 18, # 4 p. 395 - 402 Title/Abstract Full Text Show Details

Nishi, Akinori; Shuto, Takahide

Expert Opinion on Therapeutic Targets, 2017 , vol. 21, # 3 p. 259 - 272 Title/Abstract Full Text Show Details

Müller, Thomas; Foley, Paul

Clinical Pharmacokinetics, 2017 , vol. 56, # 3 p. 251 - 261 Title/Abstract Full Text Show Details

Moein, Mohammad Mahdi; El Beqqali, Aziza; Abdel-Rehim, Mohamed

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2017 , vol. 1043, p. 3 - 11 Title/Abstract Full Text Show Details

León, Kenneth S.; Martínez, Daniel E.

Journal of Psychoactive Drugs, 2017 , vol. 49, # 1 p. 22 - 30 Title/Abstract Full Text Show Details

88 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Helfer, Andreas G.; Michely, Julian A.; Weber, Armin A.; Meyer, Markus R.; Maurer, Hans H.

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2017 , vol. 1043, p. 138 - 149 Title/Abstract Full Text Show Details

Filippou, Olga; Bitas, Dimitrios; Samanidou, Victoria

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2017 , vol. 1043, p. 44 - 62 Title/Abstract Full Text Show Details

Lopez; Arnulf; Drouot; Lecendreux; Dauvilliers

Revue Neurologique, 2017 , vol. 173, # 1-2 p. 8 - 18 Title/Abstract Full Text Show Details

Nazario, Carlos Eduardo Domingues; Fumes, Bruno Henrique; da Silva, Meire Ribeiro; Lanças, Fernando Mauro

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2017 , vol. 1043, p. 81 - 95 Title/Abstract Full Text Show Details

Jalewa, Jaishree; Sharma, Mohit Kumar; Gengler, Simon; Hölscher, Christian

Neuropharmacology, 2017 , vol. 117, p. 238 - 248 Title/Abstract Full Text Show Details

Vasconcelos, Ingrid; Fernandes, Christian

TrAC - Trends in Analytical Chemistry, 2017 , vol. 89, p. 41 - 52 Title/Abstract Full Text Show Details

Dalley, Jeffrey W.; Robbins, Trevor W.

Nature Reviews Neuroscience, 2017 , vol. 18, # 3 p. 158 - 171 Title/Abstract Full Text Show Details

Ortega, Leonardo A.; Solano, José L.; Torres, Carmen; Papini, Mauricio R.

Pharmacology Biochemistry and Behavior, 2017 , vol. 154, p. 39 - 52


Title/Abstract Full Text Show Details

Gonzáles, Marco A.; Miranda, Ana Pamela; Orrego, Horacio; Silva, Rodolfo; Forray, María Inés

Neuropharmacology, 2017 , vol. 117, p. 249 - 259 Title/Abstract Full Text Show Details

Toce, Michael S.; Farias, Michael; Bruccoleri, Rebecca; Brown, David W.; Burns, Michele M.

Journal of Pediatrics, 2017 , vol. 182, p. 385 - 3,388 Title/Abstract Full Text Show Details

Turcant, Alain; Deguigne, Marie; Ferec, Séverine; Bruneau, Chloé; Leborgne, Isabelle; Lelievre, Bénédicte; Gegu, Clément; Jegou, Florence; Abbara, Chadi; Le Roux, Gaël; Boels, David

Toxicologie Analytique et Clinique, 2017 , vol. 29, # 1 p. 18 - 33 Title/Abstract Full Text Show Details

Dumestre-Toulet, Véronique; Brault, Sandrine; Labadie, Magali; Penouil-Pucheu, Françoise

Toxicologie Analytique et Clinique, 2017 , vol. 29, # 1 p. 111 - 116 Title/Abstract Full Text Show Details

Deslandes, Guillaume; Monteil-Ganière, Catherine; Grégoire, Matthieu; Allard, Sophie; Marion, Maria; Bouquié, Régis

Toxicologie Analytique et Clinique, 2017 , vol. 29, # 1 p. 134 - 138 Title/Abstract Full Text Show Details

Abbara, Chadi; Ferec, Séverine; Leroux, Gaël; Bretaudeau-Deguigne, Marie; Lelievre, Bénédicte; Boels, David; Turcant, Alain Toxicologie Analytique et Clinique, 2017 , vol. 29, # 1 p. 82 - 89 Title/Abstract Full Text Show Details

Batisse, Anne; Marillier, Maude; Chevallier, Cécile; Bourgogne, Emmanuel; Grégoire, Muriel; Laprévote, Olivier; Djezzar, Samira

Toxicologie Analytique et Clinique, 2017 , vol. 29, # 1 p. 96 - 100 Title/Abstract Full Text Show Details

Nachon-Phanithavong, Mélodie; Wille, Sarah; Richeval, Camille; Di Fazio, Vincent; Samyn, Nele; Humbert, Luc; Gaulier, Jean-Michel; Allorge, Delphine

Toxicologie Analytique et Clinique, 2017 , vol. 29, # 1 p. 41 - 46 Title/Abstract Full Text Show Details

Wille, Sarah M.R.; Eliaerts, Joy; Di Fazio, Vincent; Samyn, Nele

Toxicologie Analytique et Clinique, 2017 , vol. 29, # 1 p. 11 - 17 Title/Abstract Full Text Show Details

Bottinelli, Charline; Cartiser, Nathalie; Gaillard, Yvan; Boyer, Baptiste; Bévalot, Fabien

Toxicologie Analytique et Clinique, 2017 , vol. 29, # 1 p. 123 - 129 Title/Abstract Full Text Show Details

Allibe, Nathalie; Richeval, Camille; Willeman, Théo; Humbert, Luc; Allorge, Delphine; Maignan, Maxime; Eysseric-Guerin, Hélène; Stanke-Labesque, Françoise; Gaulier, Jean-Michel

Toxicologie Analytique et Clinique, 2017 , vol. 29, # 1 p. 101 - 110 Title/Abstract Full Text Show Details

Abiedalla, Younis; DeRuiter, Jack; Clark, C. Randall

Forensic Chemistry, 2017 , vol. 3, p. 58 - 68 Title/Abstract Full Text Show Details

89 of 317

90 of 317

Comment (Pharmacological Data)

Bioactivities present

Reference

Kelly, Peter J.; Robinson, Laura D.; Baker, Amanda L.; Deane, Frank P.; McKetin, Rebecca; Hudson, Suzie; Keane, Carol

Addictive Behaviors, 2017 , vol. 71, p. 25 - 30 Title/Abstract Full Text Show Details

Yu, Ching-Han; Chu, Shu-Chen; Chen, Pei-Ni; Hsieh, Yih-Shou; Kuo, Dong-Yih

Appetite, 2017 , vol. 113, p. 30 - 40 Title/Abstract Full Text Show Details

Wood, Michael R.; Noetzel, Meredith J.; Melancon, Bruce J.; Poslusney, Michael S.; Nance, Kellie D.; Hurtado, Miguel A.; Luscombe, Vincent B.; Weiner, Rebecca L.; Rodriguez, Alice L.; Lamsal, Atin; Chang, Sichen; Bubser, Michael; Blobaum, Anna L.; Engers, Darren W.; Niswender, Colleen M.; Jones, Carrie K.; Brandon, Nicholas J.; Wood, Michael W.; Duggan, Mark E.; Conn, P. Jeffrey; Bridges, Thomas M.; Lindsley, Craig W.

ACS Medicinal Chemistry Letters, 2017 , vol. 8, # 2 p. 233 - 238 Title/Abstract Full Text Show Details

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.; UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL – UFRGS; UNIVERSIDADE DE SÃO PAULO - USP; MECHOULAM, Raphael; BREUER, Aviva; PEREIRA KAPCZINSKI, Flavio; DE SOUZA CRIPPA, Jose Alexandre; ZUARDI, Antonio Waldo; CECILIO HALLAK, Jaime Eduardo; SILVEIRA GUIMARAES, Francisco

Patent: WO2017/8136 A2, 2017 ; Title/Abstract Full Text Show Details

91 of 317

92 of 317

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Wood, Michael R.; Noetzel, Meredith J.; Melancon, Bruce J.; Poslusney, Michael S.; Nance, Kellie D.; Hurtado, Miguel A.; Luscombe, Vincent B.; Weiner, Rebecca L.; Rodriguez, Alice L.; Lamsal, Atin; Chang, Sichen; Bubser, Michael; Blobaum, Anna L.; Engers, Darren W.; Niswender, Colleen M.; Jones, Carrie K.; Brandon, Nicholas J.; Wood, Michael W.; Duggan, Mark E.; Conn, P. Jeffrey; Bridges, Thomas M.; Lindsley, Craig W.

ACS Medicinal Chemistry Letters, 2017 , vol. 8, # 2 p. 233 - 238 Title/Abstract Full Text Show Details

Comment

physiological behaviour discussed


(Pharmacological Data) Reference

Inceptum Research and Therapeutics, Inc.; Mastronardi, Fabrizio G.

Patent: US9259409 B2, 2016 ; Title/Abstract Full Text Show Details

93 of 317

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

RUGEN HOLDINGS (CAYMAN) LIMITED; SHAPIRO, Gideon

Patent: WO2016/44323 A1, 2016 ; Title/Abstract Full Text Show Details

94 of 317

95 of 317

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Macúchová; Ševčíková; Hrebíčková; Nohejlová; Šlamberová

International Journal of Developmental Neuroscience, 2016 , vol. 51, p. 1 - 11 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

H. LUNDBECK A/S; LARSEN, Lone Frydelund; AREBERG, Johan; BREYSSE, Nathalie; CHANDRASENA, Gamini

Patent: WO2016/87429 A1, 2016 ; Title/Abstract Full Text Show Details

96 of 317

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Noven Pharmaceuticals, Inc.; Liu, Puchun; Dinh, Steven; Liao, Jun; Endo, Tsuyoshi

Patent: US2016/256406 A1, 2016 ; Title/Abstract Full Text Show Details

97 of 317

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

UNIVERSITY OF KANSAS; UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.; GOLDEN, Jennifer E.; CHUNG, Donghoon

Patent: WO2016/183093 A1, 2016 ; Title/Abstract Full Text Show Details

98 of 317

99 of 317

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Shen, Erica Y.; Jiang, Yan; Javidfar, Behnam; Kassim, Bibi; Loh, Yong-Hwee E.; Ma, Qi; Mitchell, Amanda C.; Pothula, Venu; Stewart, A Francis; Ernst, Patricia; Yao, Wei-Dong; Martin, Gilles; Shen, Li; Jakovcevski, Mira; Akbarian, Schahram

Neuropsychopharmacology, 2016 , vol. 41, # 13 p. 3103 - 3113 Title/Abstract Full Text Show Details

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

RUGEN HOLDINGS (CAYMAN) LIMITED; SHAPIRO, Gideon

Patent: WO2016/196513 A1, 2016 ; Title/Abstract Full Text Show Details

100 of 317

101 of 317

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Urs, Nikhil M.; Gee, Steven M.; Pack, Thomas F.; McCorvy, John D.; Evron, Tama; Snyder, Joshua C.; Yang, Xiaobao; Rodriguiz, Ramona M.; Borrelli, Emiliana; Wetsel, William C.; Jin, Jian; Roth, Bryan L.; O'Donnell, Patricio; Caron, Marc G.; Snyder, Solomon H.

Proceedings of the National Academy of Sciences of the United States of America, 2016 , vol. 113, # 50 p. E8178 - E8186 Title/Abstract Full Text Show Details

Comment

physiological behaviour discussed


(Pharmacological Data)

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Reference

Sucic, Sonja; Bönisch, Heinz

Neuromethods, 2016 , vol. 118, p. 1 - 21 Title/Abstract Full Text Show Details

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

CUREMARK, LLC; Fallon, Joan M.; Heil, Matthew; Szigethy, James; Fallon, James

Patent: US9492515 B2, 2016 ; Title/Abstract Full Text Show Details

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Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Szacoń, Elbieta; Rzdkowska, Marzena; Kaczor, Agnieszka A.; Kędzierska, Ewa; Fidecka, Sylwia; Matosiuk, Dariusz

Molecules, 2015 , vol. 20, # 3 p. 3821 - 3840 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Nirogi, Ramakrishna; Palacharla, Raghava Choudary; Mohammed, Abdul Rasheed; Manoharan, Arunkumar; Ponnamaneni, Ranjith Kumar; Bhyrapuneni, Gopinadh

Chemico-Biological Interactions, 2015 , vol. 230, p. 9 - 20 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Tominaga, Mariko; Michiue, Tomomi; Ishikawa, Takaki; Inamori-Kawamoto, Osamu; Oritani, Shigeki; Maeda, Hitoshi

Forensic Science International, 2015 , vol. 254, p. 118 - 125 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Randox Laboratories Ltd.; Benchik, Elouard; Fitzgerald, Peter; Lowry, Philip; McConnell, Ivan

Patent: EP2950104 A1, 2015 ; Title/Abstract Full Text Show Details

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Comment (Pharmacological Data)

physiological behaviour discussed

Reference

NORTHEASTERN UNIVERSITY; BOOTH, Raymond, G.

Patent: WO2015/179366 A1, 2015 ; Title/Abstract Full Text Show Details

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Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Finnema, Sjoerd J.; Hughes, Zoë A.; Haaparanta-Solin, Merja; Stepanov, Vladimir; Nakao, Ryuji; Varnäs, Katarina; Varrone, Andrea; Arponen, Eveliina; Marjamäki, Päivi; Pohjanoksa, Katariina; Vuorilehto, Lauri; Babalola, Phebian A.; Solin, Olof; Grimwood, Sarah; Sallinen, Jukka; Farde, Lars; Scheinin, Mika; Halldin, Christer

International Journal of Neuropsychopharmacology, 2015 , vol. 18, # 3 Title/Abstract Full Text Show Details

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Tanno, Takayuki; Maguire, David R.; Henson, Cedric; France, Charles P.

Psychopharmacology, 2014 , vol. 231, # 1 p. 85 - 95 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Calipari, Erin S.; Ferris, Mark J.; Siciliano, Cody A.; Zimmer, Benjamin A.; Jones, Sara R.


Journal of Pharmacology and Experimental Therapeutics, 2014 , vol. 349, # 2 p. 192 - 198 Title/Abstract Full Text View citing articles Show Details

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Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Chu, Shu-Chen; Chen, Pei-Ni; Hsieh, Yih-Shou; Yu, Ching-Han; Lin, Meng-Hsuan; Lin, Yan-Han; Kuo, Dong-Yih

British Journal of Pharmacology, 2014 , vol. 171, # 13 p. 3223 - 3233 Title/Abstract Full Text View citing articles Show Details

Location

Paragraph

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Akhapkina, Valentina Ivanovna; Akhapkin, Roman Vitalyevich

Patent: EP2762138 A1, 2014 ; Title/Abstract Full Text Show Details

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Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Alvaro, Giuseppe; Marasco, Agostino

Patent: US2014/323508 A1, 2014 ; Title/Abstract Full Text Show Details

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Comment (Pharmacological Data)

physiological behaviour discussed

Reference

PHILADELPHIA HEALTH AND EDUCATION CORPORATION D/B/A DREXEL UNIVERSITY COLLEGE OF MEDICINE; KORTAGERE, Sandhya; MORTENSEN, Ole Valente; MORTENSEN, Andreia C.K.

Patent: WO2014/172453 A2, 2014 ; Title/Abstract Full Text Show Details

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Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Bubser, Michael; Bridges, Thomas M.; Dencker, Ditte; Gould, Robert W.; Grannan, Michael; Noetzel, Meredith J.; Lamsal, Atin; Niswender, Colleen M.; Daniels, J. Scott; Poslusney, Michael S.; Melancon, Bruce J.; Tarr, James C.; Byers, Frank W.; Wess, Jürgen; Duggan, Mark E.; Dunlop, John; Wood, Michael W.; Brandon, Nicholas J.; Wood, Michael R.; Lindsley, Craig W.; Conn, P. Jeffrey; Jones, Carrie K.

ACS Chemical Neuroscience, 2014 , vol. 5, # 10 p. 920 - 942 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Slawinska, Anna; Wieronska, Joanna M.; Stachowicz, Katarzyna; Marciniak, Marcin; Lason-Tyburkiewicz, Magdalena; Gruca, Piotr; Papp, Mariusz; Kusek, Magdalena; Tokarski, Krzysztof; Doller, Dario; Pilc, Andrzej

British Journal of Pharmacology, 2013 , vol. 169, # 8 p. 1824 - 1839 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

Δ9-tetrahydrocannabinol discriminative stimulus; inhibition of

Species or TestSystem (Pharmacological Data)

Macaca mulatta, rhesus monkey

Sex

male and female

Route of Application

bolus (i.v.)

Concentration (Pharmacological Data)

0.32 mg/kg

Further Details (Pharmacological Data)

test system discriminated Δ9-tetrahydrocannabinol from vehicle

Results

no effect


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Reference

Schulze, David R.; Carroll, F. Ivy; McMahon, Lance R.

Psychopharmacology, 2012 , vol. 222, # 3 p. 425 - 438 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

Δ9-tetrahydrocannabinol discriminative stimulus; inhibition of

Species or TestSystem (Pharmacological Data)

Macaca mulatta, rhesus monkey

Sex

male and female

Route of Application

bolus (i.v.)

Concentration (Pharmacological Data)

1 mg/kg

Further Details (Pharmacological Data)

test system discriminated Δ9-tetrahydrocannabinol from vehicle; ED50 value of Δ9-tetrahydrocannabinol alone: 0.042 mg/kg

Type (Pharmacological Data)

ED50

Value of Type (Pharmacological Data)

0.32 mg/kg

Reference

Schulze, David R.; Carroll, F. Ivy; McMahon, Lance R.

Psychopharmacology, 2012 , vol. 222, # 3 p. 425 - 438 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

conditioned place preference; induction of

Species or TestSystem (Pharmacological Data)

Microtus ochrogaster, prairie vole

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

0.1 - 5 mg/kg

Kind of Dosing (Pharmacological Data)

title compound was prepared in saline; injected during 3 days (day 2-4) of conditioning

Type (Pharmacological Data)

effective dose

Value of Type (Pharmacological Data)

1 - 5 mg/kg

Reference

Liu, Yan; Aragona, Brandon J.; Young, Kimberly A.; Dietz, David M.; Kabbaj, Mohamed; Mazei-Robison, Michelle; Nestler, Eric J.; Wang, Zuoxin

Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 3 p. 1217 - 1222 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

mating-induced partner preferences; inhibition of

Species or TestSystem (Pharmacological Data)

Microtus ochrogaster, prairie vole

Sex

male

Route of Application

intraperitoneal


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Concentration (Pharmacological Data)

1 - 5 mg/kg

Kind of Dosing (Pharmacological Data)

title compound was prepared in saline; injected during 3 days (day 2-4) of conditioning

Type (Pharmacological Data)

effective dose

Value of Type (Pharmacological Data)

1 - 5 mg/kg

Reference

Liu, Yan; Aragona, Brandon J.; Young, Kimberly A.; Dietz, David M.; Kabbaj, Mohamed; Mazei-Robison, Michelle; Nestler, Eric J.; Wang, Zuoxin

Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 3 p. 1217 - 1222 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

mating frequency; inhibition of

Species or TestSystem (Pharmacological Data)

Microtus ochrogaster, prairie vole

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

1 - 5 mg/kg

Kind of Dosing (Pharmacological Data)

title compound was prepared in saline; injected during 3 days (day 2-4) of conditioning

Results

no effect

Reference

Liu, Yan; Aragona, Brandon J.; Young, Kimberly A.; Dietz, David M.; Kabbaj, Mohamed; Mazei-Robison, Michelle; Nestler, Eric J.; Wang, Zuoxin

Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 3 p. 1217 - 1222 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

locomotor activity; inhibition of

Species or TestSystem (Pharmacological Data)

Microtus ochrogaster, prairie vole

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

1 - 5 mg/kg

Kind of Dosing (Pharmacological Data)

title compound was prepared in saline; injected during 3 days (day 2-4) of conditioning

Results

no effect

Reference

Liu, Yan; Aragona, Brandon J.; Young, Kimberly A.; Dietz, David M.; Kabbaj, Mohamed; Mazei-Robison, Michelle; Nestler, Eric J.; Wang, Zuoxin

Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 3 p. 1217 - 1222 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

conditioned place preference; induction of

Species or TestSystem (Pharmacological Data)

Microtus ochrogaster, prairie vole


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Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

1 mg/kg

Kind of Dosing (Pharmacological Data)

title compound was prepared in saline; injected during 3 days (day 2-4) of conditioning after haloperidol or SCH23390

Further Details (Pharmacological Data)

haloperidol: nonselective dopamine receptor antagonist; SCH23390: D1-like dopamine receptor antagonist

Results

no effect

Reference

Liu, Yan; Aragona, Brandon J.; Young, Kimberly A.; Dietz, David M.; Kabbaj, Mohamed; Mazei-Robison, Michelle; Nestler, Eric J.; Wang, Zuoxin

Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 3 p. 1217 - 1222 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

conditioned place preference; induction of

Species or TestSystem (Pharmacological Data)

Microtus ochrogaster, prairie vole

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

1 mg/kg

Kind of Dosing (Pharmacological Data)

title compound was prepared in saline; injected during 3 days (day 2-4) of conditioning after eticlopride

Further Details (Pharmacological Data)

eticlopride: D2-like dopamine receptor antagonist

Type (Pharmacological Data)

effective dose

Value of Type (Pharmacological Data)

1 mg/kg

Reference

Liu, Yan; Aragona, Brandon J.; Young, Kimberly A.; Dietz, David M.; Kabbaj, Mohamed; Mazei-Robison, Michelle; Nestler, Eric J.; Wang, Zuoxin

Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 3 p. 1217 - 1222 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

density of D1R mRNA in NAcc; increase of

Species or TestSystem (Pharmacological Data)

Microtus ochrogaster, prairie vole

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

1 mg/kg

Kind of Dosing (Pharmacological Data)

title compound was prepared in saline; injected during 3 days (day 2-4) of conditioning

Further Details (Pharmacological Data)

D1R: D1 dopamine receptor; NAcc: nucleus accumbens; effective dose related to: nucleus accumbens


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Type (Pharmacological Data)

effective dose

Value of Type (Pharmacological Data)

1 mg/kg

Reference

Liu, Yan; Aragona, Brandon J.; Young, Kimberly A.; Dietz, David M.; Kabbaj, Mohamed; Mazei-Robison, Michelle; Nestler, Eric J.; Wang, Zuoxin

Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 3 p. 1217 - 1222 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

density of D2R mRNA in NAcc; increase of

Species or TestSystem (Pharmacological Data)

Microtus ochrogaster, prairie vole

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

1 mg/kg

Kind of Dosing (Pharmacological Data)

title compound was prepared in saline; injected during 3 days (day 2-4) of conditioning

Further Details (Pharmacological Data)

D2R: D2 dopamine receptor; NAcc: nucleus accumbens

Results

no effect

Reference

Liu, Yan; Aragona, Brandon J.; Young, Kimberly A.; Dietz, David M.; Kabbaj, Mohamed; Mazei-Robison, Michelle; Nestler, Eric J.; Wang, Zuoxin

Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 3 p. 1217 - 1222 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

expression of D2R mRNA in ventral tegmental area; increase of

Species or TestSystem (Pharmacological Data)

Microtus ochrogaster, prairie vole

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

1 mg/kg

Kind of Dosing (Pharmacological Data)

title compound was prepared in saline; injected during 3 days (day 2-4) of conditioning

Further Details (Pharmacological Data)

D2R: D2 dopamine receptor

Results

no effect

Reference

Liu, Yan; Aragona, Brandon J.; Young, Kimberly A.; Dietz, David M.; Kabbaj, Mohamed; Mazei-Robison, Michelle; Nestler, Eric J.; Wang, Zuoxin

Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 3 p. 1217 - 1222 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

expression of tyrosine hydroxylase mRNA in ventral tegmental area; increase of

Species or TestSystem (Pharmacological Data)

Microtus ochrogaster, prairie vole


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Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

1 mg/kg

Kind of Dosing (Pharmacological Data)

title compound was prepared in saline; injected during 3 days (day 2-4) of conditioning

Results

no effect

Reference

Liu, Yan; Aragona, Brandon J.; Young, Kimberly A.; Dietz, David M.; Kabbaj, Mohamed; Mazei-Robison, Michelle; Nestler, Eric J.; Wang, Zuoxin

Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 3 p. 1217 - 1222 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

expression of DA transporter mRNA in ventral tegmental area; increase of

Species or TestSystem (Pharmacological Data)

Microtus ochrogaster, prairie vole

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

1 mg/kg

Kind of Dosing (Pharmacological Data)

title compound was prepared in saline; injected during 3 days (day 2-4) of conditioning

Further Details (Pharmacological Data)

DA: dopamine

Results

no effect

Reference

Liu, Yan; Aragona, Brandon J.; Young, Kimberly A.; Dietz, David M.; Kabbaj, Mohamed; Mazei-Robison, Michelle; Nestler, Eric J.; Wang, Zuoxin

Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 3 p. 1217 - 1222 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

mating-induced partner preferences; inhibition of

Species or TestSystem (Pharmacological Data)

Microtus ochrogaster, prairie vole

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

1 - 5 mg/kg

Kind of Dosing (Pharmacological Data)

title compound was prepared in saline; injected during 3 days (day 2-4) of conditioning after SCH23390 (0.4 ng/kg) intra-NAcc injection

Further Details (Pharmacological Data)

NAcc: nucleus accumbens; SCH23390: D1-like receptor antagonist; effective dose related to: nucleus accumbens

Type (Pharmacological Data)

effective dose

Value of Type (Pharmacological Data)

1 mg/kg

Reference

Liu, Yan; Aragona, Brandon J.; Young, Kimberly A.; Dietz, David M.; Kabbaj, Mohamed; Mazei-Robison, Michelle; Nestler,


Eric J.; Wang, Zuoxin

Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 3 p. 1217 - 1222 Title/Abstract Full Text View citing articles Show Details

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Effect (Pharmacological Data)

mating-induced partner preferences; inhibition of

Species or TestSystem (Pharmacological Data)

Microtus ochrogaster, prairie vole

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

1 - 5 mg/kg

Kind of Dosing (Pharmacological Data)

title compound was prepared in saline; injected during 3 days (day 2-4) of conditioning after SCH23390 (100 ng/kg) intra-NAcc injection

Further Details (Pharmacological Data)

NAcc: nucleus accumbens; SCH23390: D1-like receptor antagonist

Results

no effect (related to nucleus accumbens)

Reference

Liu, Yan; Aragona, Brandon J.; Young, Kimberly A.; Dietz, David M.; Kabbaj, Mohamed; Mazei-Robison, Michelle; Nestler, Eric J.; Wang, Zuoxin

Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 3 p. 1217 - 1222 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

prepulse intensity; suppression of

Species or TestSystem (Pharmacological Data)

mouse

Sex

male and female

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

1 - 10 mg/kg

Further Details (Pharmacological Data)

not clear from the article neurotensin-1 receptor null or wild type mice; 4-16 db acoustic stimulation

Type (Pharmacological Data)

prepulse inhibition

Value of Type (Pharmacological Data)

8.77 - 70.64 percent

Reference

Feifel; Pang; Shilling; Melendez; Schreiber; Button

Neuropharmacology, 2010 , vol. 58, # 1 p. 173 - 178 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

duration of immobility; decrease of

Species or TestSystem (Pharmacological Data)

Swiss albino mouse

Sex

male and female

Route of Application

peroral

Concentration (Pharmacological

5 mg/kg


Data)

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Kind of Dosing (Pharmacological Data)

comparative comp. administered as sulphate

Further Details (Pharmacological Data)

duration of immobility in control: 370 s; mass of species: 18 - 25 g

Type (Pharmacological Data)

duration of immobility

Value of Type (Pharmacological Data)

33.2 s

Reference

Umukoro, Solomon; Aladeokin, Aderemi Caleb

Journal of Ethnopharmacology, 2010 , vol. 127, # 3 p. 768 - 770 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or TestSystem (Pharmacological Data)

Caco-2 cells seeded artificial membrane

Concentration (Pharmacological Data)

10 μmol/l

Kind of Dosing (Pharmacological Data)

title comp. dissolved in DMSO

Further Details (Pharmacological Data)

permeability coefficient A-B (Papp, A-B)

Type (Pharmacological Data)

Papp, A-B

Value of Type (Pharmacological Data)

40.35*1E-6 cm/s

Reference

Skolnik, Suzanne; Lin, Xuena; Wang, Jianling; Chen, Xiao-Hui; He, Timothy; Zhang, Bailin

Journal of Pharmaceutical Sciences, 2010 , vol. 99, # 7 p. 3246 - 3265 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or TestSystem (Pharmacological Data)

Caco-2 cells seeded artificial membrane

Concentration (Pharmacological Data)

10 μmol/l

Kind of Dosing (Pharmacological Data)

title comp. dissolved in DMSO

Further Details (Pharmacological Data)

permeability coefficient B-A (Papp, B-A)

Type (Pharmacological Data)

Papp, B-A

Value of Type (Pharmacological Data)

21.14*1E-6 cm/s

Reference

Skolnik, Suzanne; Lin, Xuena; Wang, Jianling; Chen, Xiao-Hui; He, Timothy; Zhang, Bailin

Journal of Pharmaceutical Sciences, 2010 , vol. 99, # 7 p. 3246 - 3265 Title/Abstract Full Text View citing articles Show Details


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Effect (Pharmacological Data)

basal dopamine outflow; induction of

Species or TestSystem (Pharmacological Data)

Sprague-Dawley rat

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

0.5 mg/kg

Kind of Dosing (Pharmacological Data)

title comp. admnistered as sulfate

Further Details (Pharmacological Data)

mass of species: 330 - 380 g; dopamine outflow rate related to: striatum

Type (Pharmacological Data)

dopamine outflow rate

Value of Type (Pharmacological Data)

Ca. 324 percent

Reference

Auclair, Agnes L.; Cathala, Adeline; Sarrazin, Frederic; Depoortere, Ronan; Piazza, Pier Vincenzo; Newman-Tancredi, Adrian; Spampinato, Umberto

Journal of Neurochemistry, 2010 , vol. 114, # 5 p. 1323 - 1332 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

basal dopamine outflow; induction of

Species or TestSystem (Pharmacological Data)

Sprague-Dawley rat

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

0.5 mg/kg

Kind of Dosing (Pharmacological Data)

title comp. admnistered as sulfate

Further Details (Pharmacological Data)

mass of species: 330 - 380 g; dopamine outflow rate related to: nucleus accumbens

Type (Pharmacological Data)

dopamine outflow rate

Value of Type (Pharmacological Data)

Ca. 349 perent

Reference

Auclair, Agnes L.; Cathala, Adeline; Sarrazin, Frederic; Depoortere, Ronan; Piazza, Pier Vincenzo; Newman-Tancredi, Adrian; Spampinato, Umberto

Journal of Neurochemistry, 2010 , vol. 114, # 5 p. 1323 - 1332 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

enzyme activity; inhibition of

Species or TestSystem (Pharmacological Data)

brain mitochondria of rat

Further Details

inhibition constant (Ki); Ki related to: monoamine oxidase A


(Pharmacological Data)

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Type (Pharmacological Data)

Ki

Value of Type (Pharmacological Data)

12.2 μmol/l

Reference

Vilches-Herrera, Marcelo; Miranda-Sepulveda, Juan; Rebolledo-Fuentes, Marco; Fierro, Angelica; Luehr, Susan; IturriagaVasquez, Patricio; Cassels, Bruce K.; Reyes-Parada, Miguel

Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 6 p. 2452 - 2460 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

enzyme activity; inhibition of

Species or TestSystem (Pharmacological Data)

brain mitochondria of rat

Results

molecular target: monoamine oxidase A

Reference

Vilches-Herrera, Marcelo; Miranda-Sepulveda, Juan; Rebolledo-Fuentes, Marco; Fierro, Angelica; Luehr, Susan; IturriagaVasquez, Patricio; Cassels, Bruce K.; Reyes-Parada, Miguel

Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 6 p. 2452 - 2460 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

enzyme activity; inhibition of

Species or TestSystem (Pharmacological Data)

brain mitochondria of rat

Concentration (Pharmacological Data)

100 μmol/l

Results

no effect (related to monoamine oxidase B)

Reference

Vilches-Herrera, Marcelo; Miranda-Sepulveda, Juan; Rebolledo-Fuentes, Marco; Fierro, Angelica; Luehr, Susan; IturriagaVasquez, Patricio; Cassels, Bruce K.; Reyes-Parada, Miguel

Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 6 p. 2452 - 2460 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

behavioral

Species or TestSystem (Pharmacological Data)

α1G-/- transgenic mouse

Method (Pharmacological Data)

Example 2 Investigation of Behavioral Changes of Transgenic Mice Deficient in α1G T-Type Calcium Channel Investigation of Reactivity to a New Environment In order to investigate reactivity to a new environment and a strange subject of α1G calcium channel transgenic mice, the present inventors transferred them to a breeding cage and an openfield to observe their behavioral changes. First, for the analysis of behavioral aspect of a transgenic mouse in a new breeding cage, each mouse was raised dependently in a cage for 24 hours. Then, the mouse was transferred to a new cage and its behavior was recorded for 1 hour by DDC camera. A person who was not informed about its genotype observed the behavior by the recorded tape. For reactivity test in an openfield, a test animal was transferred to a test room one hour before the test began and each animal was put in an independent breeding cage for adaptation. The floor of the openfield (white acryl, 50.x.50.x.50 cm) was covered with 0.5 cm litter, on which a test animal was put and locomotor of the animal was observed for 1 hour. As a result, mobility of both a wild type α1G +/+ mouse and a transgenic α1G -/- mouse was significantly increased in an early stage while they were searching a new environment. In particular, reactivity to a new subject of a transgenic mouse was much increased, comparing to a wild type (FIGS. 1 and 2). Particularly, when a mouse was freed in an openfield, searching motility was increased for the initial 30 minutes, and when an animal was put in a new breeding cage, searching motility was increased for the early 20 minutes. However, the searching motility was no more increased after habituation in both a wild type α1G +/+ mouse and a transgenic α1G -/mouse, and no difference between the two groups was observed at last. Investigation of Reactivity to a New Subject In order to verify the result obtained in the above Example , the present inventors provided a new material in each cage to investigate reactivity. A mouse was transferred from a familiar old cage to a temporary cage to provide a new material in the old cage. Precisely, two identical subjects (size: 3.x.3.x.3 cm, weight: 2.5 g, styrofoam rolled up with paper tape) were put at 10 cm distance from the end of one side. Then, a mouse was back to the familiar cage with its head facing opposite side from the subjects. Its' behavior was observed for 15 minutes. The subjects were not fixed on the floor, suggesting they were movable. All the behavior of the test animal during the test was recorded by a video camera for further analysis. Behavioral analysis was performed by measuring the moving distance for 1 hour; a latency period until the first contact to a new subject; contact time for 15 minutes; contact frequency and pattern; and moving distance of the subject. "Contact" means when a nose of a mouse was heading toward a new subject within a 2 cm-radius or directly touching the subject. Contact patterns are classified into approaching which means a nose of the test animal is heading toward or directly touching a provided subject, digging which means the animal is digging litters around the subject with its nose heading toward the subject, pushing which means the animal moves the subject with its nose, towing which means the animal moves the subject with its forefeet and biting which means the animal


moves the subject with its mouth. After observing reactivity to a new subject, a unique behavior that has not been observed in any other so far was seen in an α1G -/- mouse. Approaching time to a new material was shorter but contact time was longer, comparing to a wild type mouse (FIG. 3C). Behavioral pattern was also unique, that is, digging around the material, biting, pulling and dragging the material, which were all hardly seen in wild type mice (FIG. 3D). In early stage, a test animal was simply hunting the new circumst Location

Page/Page column 3; 6; Sheet 8

Comment (Pharmacological Data)

No effect

Reference

Korea Institute of Science and Technology

Patent: US2008/15163 A1, 2008 ; Title/Abstract Full Text Show Details

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Effect (Pharmacological Data)

protein association; increase of

Species or TestSystem (Pharmacological Data)

HEK293 cells expressing MSR and FLAG-tagged human DAT

Concentration (Pharmacological Data)

10 μmol/l

Method (Pharmacological Data)

cells transfected with syntaxin 1A (SYN1A); treated with title comp. for 5 min at 37 deg C; lysed; DAT proteins immunoprecipitated using anti-FLAG antibody; immunoblot analysis performed for SYN1A using anti-HPC-1 antibody; DAT/SYN1A association detd.

Further Details (Pharmacological Data)

control: vehicle; MSR: macrophage scavenger receptor; DAT: dopamine transporter; HEK: human embryonic kidney

Results

title comp. increased DAT/SYN1A association but had no effect on total levels of SYN1A; amount of DAT recovered in immunoprecipitated fraction after title comp. treatment was 104percent of control; fig.

Reference

Binda, Francesca; Dipace, Concetta; Bowton, Erica; Robertson, Sabrina D.; Lute, Brandon J.; Fog, Jacob U.; Zhang, Minjia; Sen, Namita; Colbran, Roger J.; Gnegy, Margaret E.; Gether, Ulrik; Javitch, Jonathan A.; Erreger, Kevin; Galli, Aurelio

Molecular Pharmacology, 2008 , vol. 74, # 4 p. 1101 - 1108 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

protein association; increase of

Species or TestSystem (Pharmacological Data)

HEK293 cells expressing MSR and FLAG-tagged human DAT

Concentration (Pharmacological Data)

10 μmol/l

Method (Pharmacological Data)

cells transfected with syntaxin 1A (SYN1A); treated with title comp. (5 min, 37 deg C); labeled with biotin; lysed; immunoprecipitated using anti-FLAG antibody; immunoblot analysis done for SYN1A using anti-HPC-1 antibody; DAT/SYN1A association detd.

Further Details (Pharmacological Data)

control: vehicle; MSR: macrophage scavenger receptor; DAT: dopamine transporter; HEK: human embryonic kidney; further study: effect of KN93 or Ca(2+)/calmodulin-dependent protein kinase II inhibitor peptide (CaMKIINtide) on title comp. activity

Results

title comp. increased interaction between DAT and SYN1A; amount of DAT recovered in immunoprecipitated fraction after title comp. treatment was 101percent of control; KN93 and CaMKIINtide blocked title comp. activity; fig.

Reference

Binda, Francesca; Dipace, Concetta; Bowton, Erica; Robertson, Sabrina D.; Lute, Brandon J.; Fog, Jacob U.; Zhang, Minjia; Sen, Namita; Colbran, Roger J.; Gnegy, Margaret E.; Gether, Ulrik; Javitch, Jonathan A.; Erreger, Kevin; Galli, Aurelio

Molecular Pharmacology, 2008 , vol. 74, # 4 p. 1101 - 1108 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

protein association; increase of

Species or TestSystem (Pharmacological Data)

synaptosomes from striatum of mouse

Concentration (Pharmacological Data)

10 μmol/l

Method

synaptosomes treated with title comp. for 5 min at 37 deg C; lysed; lysed; DAT proteins immunoprecipitated using anti-FLAG antibody;


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146 of 317

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(Pharmacological Data)

immunoblot analysis performed for SYN1A using anti-HPC-1 antibody; DAT/SYN1A association detd.

Further Details (Pharmacological Data)

control: vehicle; DAT: dopamine transporter; SYN1A: syntaxin 1A

Results

title comp. increased DAT/SYN1A association; amount of DAT recovered in immunoprecipitated fraction after title comp. treatment was 105percent of control; fig.

Reference

Binda, Francesca; Dipace, Concetta; Bowton, Erica; Robertson, Sabrina D.; Lute, Brandon J.; Fog, Jacob U.; Zhang, Minjia; Sen, Namita; Colbran, Roger J.; Gnegy, Margaret E.; Gether, Ulrik; Javitch, Jonathan A.; Erreger, Kevin; Galli, Aurelio

Molecular Pharmacology, 2008 , vol. 74, # 4 p. 1101 - 1108 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

protein association; increase of

Species or TestSystem (Pharmacological Data)

synaptosomes from striatum of mouse

Concentration (Pharmacological Data)

10 μmol/l

Method (Pharmacological Data)

synaptosomes treated with title comp. for 5 min at 37 deg C; labeled with biotin; lysed; DAT proteins immunoprecipitated using anti-FLAG antibody; immunoblot analysis performed for SYN1A using anti-HPC-1 antibody; DAT/SYN1A association detd.

Further Details (Pharmacological Data)

control: vehicle; DAT: dopamine transporter; SYN1A: syntaxin 1A

Results

title comp. increased interaction between DAT and SYN1A; amount of DAT recovered in immunoprecipitated fraction after title comp. treatment was 102percent of control; fig.

Reference

Binda, Francesca; Dipace, Concetta; Bowton, Erica; Robertson, Sabrina D.; Lute, Brandon J.; Fog, Jacob U.; Zhang, Minjia; Sen, Namita; Colbran, Roger J.; Gnegy, Margaret E.; Gether, Ulrik; Javitch, Jonathan A.; Erreger, Kevin; Galli, Aurelio

Molecular Pharmacology, 2008 , vol. 74, # 4 p. 1101 - 1108 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

transmitter releasing

Species or TestSystem (Pharmacological Data)

HEK293 cells expressing MSR and FLAG-tagged human DAT

Concentration (Pharmacological Data)

10 μmol/l

Method (Pharmacological Data)

cells transfected with syntaxin 1A (SYN1A); incub. with DA for 30 min at 37 deg C; placed in superfusion apparatus; perfused with title comp. for 2 min at 3-10 min; DA release quantified by HPLC

Further Details (Pharmacological Data)

control: cells transiently transfected with empty vector; DAT: dopamine (DA) transporter; HEK: human embryonic kidney

Results

title comp. stimulated DAT-mediated DA efflux; transfection of SYN1A signif. increased ability of title comp. to stimulate DA efflux with respect to vector-transfected control; fig.

Reference

Binda, Francesca; Dipace, Concetta; Bowton, Erica; Robertson, Sabrina D.; Lute, Brandon J.; Fog, Jacob U.; Zhang, Minjia; Sen, Namita; Colbran, Roger J.; Gnegy, Margaret E.; Gether, Ulrik; Javitch, Jonathan A.; Erreger, Kevin; Galli, Aurelio

Molecular Pharmacology, 2008 , vol. 74, # 4 p. 1101 - 1108 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

transmitter releasing

Species or TestSystem (Pharmacological Data)

HEK293 cells expressing MSR and FLAG-tagged human DAT

Concentration (Pharmacological Data)

10 μmol/l

Method (Pharmacological

cells transfected with syntaxin 1A (SYN1A); clamped in whole-cell patch-clamp configuration at -60 mV; perfused with DA + GST (gluthathione transferase) or GST-SYN1A; title comp. and cocaine added into bath; DA efflux detd. by ampherometric electrode e


Data)

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149 of 317

150 of 317

Further Details (Pharmacological Data)

control: without title comp.; MSR: macrophage scavenger receptor; DAT: dopamine (DA) transporter; HEK: human embryonic kidney; GST-SYN1A: GST fusion protein with soluble SYN1AδTM; further, effect of KN93 on title comp. activity studied

Results

title comp. induced DA efflux in cells perfused with GST-SYN1A but not with control GST; KN93 blocked SYN1A stimulation of title comp.induced efflux; fig.

Reference

Binda, Francesca; Dipace, Concetta; Bowton, Erica; Robertson, Sabrina D.; Lute, Brandon J.; Fog, Jacob U.; Zhang, Minjia; Sen, Namita; Colbran, Roger J.; Gnegy, Margaret E.; Gether, Ulrik; Javitch, Jonathan A.; Erreger, Kevin; Galli, Aurelio

Molecular Pharmacology, 2008 , vol. 74, # 4 p. 1101 - 1108 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

transmitter releasing

Species or TestSystem (Pharmacological Data)

midbrain dopaminergic neurons of mouse

Concentration (Pharmacological Data)

10 μmol/l

Method (Pharmacological Data)

neurons from mouse pups; clamped in whole-cell patch-clamp configuration at -60 mV; perfused with DA + GST (gluthathione transferase) or GST-SYN1A; title comp. and cocaine added into bath; DA efflux detd. by ampherometric electrode

Further Details (Pharmacological Data)

control: without title comp.; GST-SYN1A: GST fusion protein with soluble SYN1AδTM; DA: dopamine

Results

title comp. induced DA efflux in cells perfused with GST-SYN1A but not with control GST; fig.

Reference

Binda, Francesca; Dipace, Concetta; Bowton, Erica; Robertson, Sabrina D.; Lute, Brandon J.; Fog, Jacob U.; Zhang, Minjia; Sen, Namita; Colbran, Roger J.; Gnegy, Margaret E.; Gether, Ulrik; Javitch, Jonathan A.; Erreger, Kevin; Galli, Aurelio

Molecular Pharmacology, 2008 , vol. 74, # 4 p. 1101 - 1108 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

protein expression; inhibition of

Species or TestSystem (Pharmacological Data)

catecholaminergic cells (CAD)

Concentration (Pharmacological Data)

10 μmol/l

Method (Pharmacological Data)

cells stably transfected with full-length hNET or hNETΔ28-47 were treated with title comp. for 1-60 min; proteins recovered from biotinylated extracts were analyzed by Western blotting for the levels of hNET proteins

Further Details (Pharmacological Data)

hNET: human norepinephrine transporter

Results

title comp. decreased the levels of hNET proteins by ca. 50percent at 60 min both in cells transfected with full-length hNET and with hNETΔ28-47; the decrease was achieved faster in cells transfected with hNETΔ28-47

Reference

Dipace, Concetta; Sung, Uhna; Binda, Francesca; Blakely, Randy D.; Galli, Aurelio

Molecular Pharmacology, 2007 , vol. 71, # 1 p. 230 - 239 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

protein expression; inhibition of

Species or TestSystem (Pharmacological Data)

catecholaminergic cells (CAD)

Concentration (Pharmacological Data)

10 μmol/l

Method (Pharmacological Data)

cells stably transfected with hNETΔ28-47 were treated with title comp. for 1 min; proteins recovered from biotinylated extracts were analyzed by Western blotting for the levels of hNET proteins

Further Details

hNET: human norepinephrine transporter; further investigation with a calcium channel blocker, BAPTA-AM, NET antagonist and CAMKII


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(Pharmacological Data)

inhibitor

Results

title comp. rapidly reduced hNETΔ28-47 surface expression; the effect was Ca(2+)-dependent, NET and CAMKII were possibly involved

Reference

Dipace, Concetta; Sung, Uhna; Binda, Francesca; Blakely, Randy D.; Galli, Aurelio

Molecular Pharmacology, 2007 , vol. 71, # 1 p. 230 - 239 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

intracellular calcium level; increase of

Species or TestSystem (Pharmacological Data)

catecholaminergic cells (CAD)

Concentration (Pharmacological Data)

10 μmol/l

Method (Pharmacological Data)

cells stably transfected with full-length hNET or hNETΔ28-47 were incubated with 5 μM Oregon Green BAPTA-AM for 20 min at room tempetature; the effect of title comp. on intracellular calcium fluorescence was analyzed

Further Details (Pharmacological Data)

control: vehicle; hNET: human norepinephrine transporter; BAPTA-AM: 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acidacetoxymethyl ester; further investigation with a calcium channel blocker and NET inhibitor

Results

title comp. increased fluorescence within 10 s both in cells transfected with full-length hNET and with hNETΔ28-47; a stronger increase was observed in cells transfected with hNETΔ28-47; calcium channels and NET were possibly involved

Reference

Dipace, Concetta; Sung, Uhna; Binda, Francesca; Blakely, Randy D.; Galli, Aurelio

Molecular Pharmacology, 2007 , vol. 71, # 1 p. 230 - 239 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

enzyme; induction of

Species or TestSystem (Pharmacological Data)

catecholaminergic cells (CAD)

Concentration (Pharmacological Data)

10 μmol/l

Method (Pharmacological Data)

cells stably transfected with hNETΔ28-47 were incubated with title comp. for 1-10 min; the effect on CAMKII phosphorylation at Thr286 was analyzed by Western blotting

Further Details (Pharmacological Data)

control: vehicle; hNET: human norepinephrine transporter; further investigation with NET inhibitor

Results

title comp. rapidly increased the level of CAMKII phosphorylation; NET was possibly involved

Reference

Dipace, Concetta; Sung, Uhna; Binda, Francesca; Blakely, Randy D.; Galli, Aurelio

Molecular Pharmacology, 2007 , vol. 71, # 1 p. 230 - 239 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

protein interaction; induction of

Species or TestSystem (Pharmacological Data)

catecholaminergic cells (CAD)

Concentration (Pharmacological Data)

10 μmol/l

Method (Pharmacological Data)

cells cotransfected with His-hNET or His-hNETΔ28-47 and SYN1A were incubated with title comp. for 1 min; after biotinylation bound hNET proteins were immunoprecipitated with anti-His antibody, resolved on SDS-PAGE and immunoblotted for SYN1A

Further Details (Pharmacological Data)

control: vehicle; hNET: human norepinephrine transporter; SYN1A: syntaxin 1A; further investigation with CAMKII inhibitor

Results

title comp. increased hNET/SYN1A and hNETΔ28-47 interactions at plasma membrane by 130 and 191percent, resp.; no effect on intracellular interactions was observed; CAMKII possibly involved


154 of 317

Reference

Dipace, Concetta; Sung, Uhna; Binda, Francesca; Blakely, Randy D.; Galli, Aurelio

Molecular Pharmacology, 2007 , vol. 71, # 1 p. 230 - 239 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

body weight; effect on

Species or TestSystem (Pharmacological Data)

rat

Route of Application

intraperitoneal

Method (Pharmacological Data)

In vivo testing for antiobesic activity The in-vivo testing for antiobesic activity of the inventive pyrazoline compounds is carried out as described in the publication of G. Colombo et al., "Appetite Suppression and Weight Loss after the Cannabinoid Antagonist SR 141716"; Life Sciences, 63 (8), 113-117, (1998). The respective part of the description is hereby incorporated by reference and forms part of the present disclosure. III. In-vivo testing for antiobesic activity The in-vivo testing for antiobesic activity was carried out as described above, whereby four different groups of 10 rats each were treated as follows:Group I: Group was treated with vehicle, namely arabic gum (5 wt.percent) in water.Group II: The second group of rats was treated with the inventive compound N-piperidinyl-5-(4-chlorophenyl)-1-(2,4dichlorophenyl)-4,5-dihydropyrazole-3-carboxamide according to Example 1. Said compound was administered intraperitoneally to the rats over a period of 14 days in a daily dosis of (10 mg/kg body weight).Group III: The third group of rats was treated with Amphetamine, an active ingredient known to reduce appetite. Said compound was administered intraperitoneally to the rats over a period of 14 days in a daily dosis of (5 mg/kg body weight). As can be seen from Figure 1 the body weight is lowered due to the administration of the inventive compound according to example 11 and this effect is also observed after the treatment is ended. Figure 2 shows the reduction of food intake due to the administration of the inventive compound according to example 11.

Results

The body weight is lowered due to the administration of the test compound; figure given

Location

Page/Page column title page; 37; 44; 51

Reference

Laboratorios del Dr. Esteve S.A.

Patent: EP1745783 A1, 2007 ; Title/Abstract Full Text Show Details

155 of 317

Effect (Pharmacological Data)

food intake; reduction of

Species or TestSystem (Pharmacological Data)

rat

Route of Application

intraperitoneal

Method (Pharmacological Data)

In vivo testing for antiobesic activity The in-vivo testing for antiobesic activity of the inventive pyrazoline compounds is carried out as described in the publication of G. Colombo et al., "Appetite Suppression and Weight Loss after the Cannabinoid Antagonist SR 141716"; Life Sciences, 63 (8), 113-117, (1998). The respective part of the description is hereby incorporated by reference and forms part of the present disclosure. III. In-vivo testing for antiobesic activity The in-vivo testing for antiobesic activity was carried out as described above, whereby four different groups of 10 rats each were treated as follows:Group I: Group was treated with vehicle, namely arabic gum (5 wt.percent) in water.Group II: The second group of rats was treated with the inventive compound N-piperidinyl-5-(4-chlorophenyl)-1-(2,4dichlorophenyl)-4,5-dihydropyrazole-3-carboxamide according to Example 1. Said compound was administered intraperitoneally to the rats over a period of 14 days in a daily dosis of (10 mg/kg body weight).Group III: The third group of rats was treated with Amphetamine, an active ingredient known to reduce appetite. Said compound was administered intraperitoneally to the rats over a period of 14 days in a daily dosis of (5 mg/kg body weight). As can be seen from Figure 1 the body weight is lowered due to the administration of the inventive compound according to example 11 and this effect is also observed after the treatment is ended. Figure 2 shows the reduction of food intake due to the administration of the inventive compound according to example 11.

Results

The reduction of food intake due to the test compound; figure given

Location

Page/Page column 37; 44; 52

Reference

Laboratorios del Dr. Esteve S.A.

Patent: EP1745783 A1, 2007 ; Title/Abstract Full Text Show Details

156 of 317

Effect (Pharmacological Data)

antiobesic activity

Species or TestSystem (Pharmacological Data)

rat

Route of Application

intraperitoneal

Method (Pharmacological Data)

III. In vivo testing for antiobesic activityThe in-vivo testing for antiobesic activity of the inventive pyrazoline compounds is carried out as described in the publication of G. Colombo et al., .Appetite Suppression and Weight Loss after the Cannabinoid Antagonist SR 141716"; Life Sciences, 63 (8), 113-117, (1998). The respective part of the description is hereby incorporated by reference and forms part of the present


disclosure.; III. In vivo testing for antiobesic activityThe in-vivo testing for antiobesic activity of the inventive pyrazoline compounds is carried out as described in the publication of G. Colombo et al., .Appetite Suppression and Weight Loss after the Cannabinoid Antagonist SR 141716"; Life Sciences, 63 (8), 113-117, (1998). The respective part of the description is hereby incorporated by reference and forms part of the present disclosure. Results

Results are given in figure 1 and 2.

Location

Page/Page column 80; 135; sheet 1, sheet 2

Reference

LABORATORIOS DEL DR. ESTEVE, S.A.

Patent: WO2007/9708 A1, 2007 ; Title/Abstract Full Text Show Details

157 of 317

Effect (Pharmacological Data)

anti-obesic activity

Species or TestSystem (Pharmacological Data)

rat

Route of Application

intraperitoneal

Method (Pharmacological Data)

In vivo testing for antiobesic activity The in-vivo testing for antiobesic activity of the inventive pyrazoline compounds is carried out as described in the publication of G. Colombo et al., "Appetite Suppression and Weight Loss after the Cannabinoid Antagonist SR 141716"; Life Sciences, 63 (8), 113-117, (1998). The respective part of the description is hereby incorporated by reference and forms part of the present disclosure.III. In-vivo testing for antiobesic activity The in-vivo testing for antiobesic activity was carried out as described above, whereby four different groups of 10 rats each were treated as follows:Group I: Group was treated with vehicle, namely arabic gum (5 wt.percent) in water.Group II: The second group of rats was treated with the inventive compound N-piperidinyl-5-(4-chlorophenyl)-1-(2,4dichlorophenyl)-4,5-dihydropyrazole-3-carboxamide according to Example 1. Said compound was administered intraperitoneally to the rats over a period of 14 days in a daily dosis of (10 mg/kg body weight).Group III: The third group of rats was treated with Amphetamine, an active ingredient known to reduce appetite. Said compound was administered intraperitoneally to the rats over a period of 14 days in a daily dosis of (5 mg/kg body weight). As can be seen from Figure 1 the body weight is lowered due to the administration of the inventive compound according to example 1 and this effect is also observed after the treatment is ended. Figure 2 shows the reduction of food intake due to the administration of the inventive compound according to example 1.

Results

title compound was administered at the dose of 5 mg/kg body weight; body weight is lowered due to the administration of the title compound; see Fig. 1

Location

Page/Page column 12; 17

Reference

LABORATORIOS DEL DR. ESTEVE, S.A.

Patent: EP1757588 A1, 2007 ; Title/Abstract Full Text Show Details

158 of 317

Effect (Pharmacological Data)

food intake; reduction of

Species or TestSystem (Pharmacological Data)

rat

Route of Application

intraperitoneal

Method (Pharmacological Data)

In vivo testing for antiobesic activity The in-vivo testing for antiobesic activity of the inventive pyrazoline compounds is carried out as described in the publication of G. Colombo et al., "Appetite Suppression and Weight Loss after the Cannabinoid Antagonist SR 141716"; Life Sciences, 63 (8), 113-117, (1998). The respective part of the description is hereby incorporated by reference and forms part of the present disclosure.III. In-vivo testing for antiobesic activity The in-vivo testing for antiobesic activity was carried out as described above, whereby four different groups of 10 rats each were treated as follows:Group I: Group was treated with vehicle, namely arabic gum (5 wt.percent) in water.Group II: The second group of rats was treated with the inventive compound N-piperidinyl-5-(4-chlorophenyl)-1-(2,4dichlorophenyl)-4,5-dihydropyrazole-3-carboxamide according to Example 1. Said compound was administered intraperitoneally to the rats over a period of 14 days in a daily dosis of (10 mg/kg body weight).Group III: The third group of rats was treated with Amphetamine, an active ingredient known to reduce appetite. Said compound was administered intraperitoneally to the rats over a period of 14 days in a daily dosis of (5 mg/kg body weight). As can be seen from Figure 1 the body weight is lowered due to the administration of the inventive compound according to example 1 and this effect is also observed after the treatment is ended. Figure 2 shows the reduction of food intake due to the administration of the inventive compound according to example 1.

Results

title compound was administered at the dose of 5 mg/kg body weight; administration of title compound resulted in the reduction of food intake; see Fig. 2

Location

Page/Page column 12; 17

Reference

LABORATORIOS DEL DR. ESTEVE, S.A.

Patent: EP1757588 A1, 2007 ; Title/Abstract Full Text Show Details

159 of 317

Effect (Pharmacological Data)

locomotor activity; stimulation of


Species or TestSystem (Pharmacological Data)

mouse

Sex

male

Route of Application

intraperitoneal

Method (Pharmacological Data)

8. EXAMPLE 3 Mice (male, 8 weeks of age; 129S6/SvEv from Taconic) were housed in groups of five for one week. Animals were injected (i.p.) with either vehicle (diluent:saline at a ratio of 3:50 v/v), or one of two doses of GR341 (1 mg/kg and 3 mg/kg). After 15 minutes, animals were injected (i.p.) either with saline or Amphetamine at 3 mg/kg. Mice were held individually without food or water for an additional 15 minutes and then placed in Plexiglas activity chambers (model ENV-520; Med Associates, St. Albans, Vt.) (43.2 cm long.x.43.2 cm wide.x.30.5 cm high) to assess locomotor activity. Mice were placed into the center of the open field, and activity was recorded for 30 minutes with subtotals for 5-minute increments. Testing was performed in darkness to minimize anxiety. As shown in FIG. 17, each dose of GR341 inhibited amphetamine-induced locomotor activity. There was no significant effect of either dose of GR341 alone on locomotor activity.; FIG. 17. Effect of GR341 on locomotor activity in the context of various doses of amphetamine.

Results

title compound induced locomotor activity; for more details see fig. 17

Location

Page/Page column 3; 6

Reference

GOUAUX, ERIC; SONG, Langzhou; XIE, Yuli; LANDRY, Donald W.

Patent: US2007/293573 A1, 2007 ; Title/Abstract Full Text Show Details

160 of 317

Effect (Pharmacological Data)

electrophysiologic current; effect on

Species or TestSystem (Pharmacological Data)

Xenopus laevis oocyte with microinjected GluR2 receptor-encoding mRNA of rat

Method (Pharmacological Data)

FIG. 16A-E. Electrophysiologic studies comparing GR341 with LY451646. A. Microamperes of current over various periods of time in a GluR2 expressing oocyte (Xenopus lacevis oocyte with microinjected rat GluR2 receptor-encoding mRNA), exposed to various concentrations (0.001 μM, 0.01 μM, 0.1 μM and 1 μM) of GR341 (formula 5). B. Microamperes of current over various periods of time in a GluR2 expressing oocyte exposed to various concentrations (0.001 μM, 0.01 μM, 0.1 μM, 1 μM and 10 μM) of LY451646. C. In an oocyte expressing GluR2, ratio of current/maximal current (I/Imax) versus concentration of GR341. D. In an oocyte expressing GluR2, ratio of current/maximal current (I/Imax) versus concentration of LY451646. E. GR341.; 7. EXAMPLE 2 Electrophysiologic studies were performed comparing GR341 (formula 5) with LY451646 in cells expressing the GluR2 receptor, with results shown in FIG. 16A-D. GR341 was observed to have an EC50 of 12.7+/-0.6 nM, and therefore was more potent than LY451646, which was observed to have an EC50 of 129.5+/-16.0 nM.

Type (Pharmacological Data)

EC50

Value of Type (Pharmacological Data)

12.7 nmol/l

Results

electrophysiologic current was reduced; I/Imax EC50 was measured; more details see fig. 16A, 16C

Location

Page/Page column 3; 6

Reference

GOUAUX, ERIC; SONG, Langzhou; XIE, Yuli; LANDRY, Donald W.

Patent: US2007/293573 A1, 2007 ; Title/Abstract Full Text Show Details

161 of 317

Effect (Pharmacological Data)

monoamine transporter; interaction with

Species or TestSystem (Pharmacological Data)

rat caudate putamen crude vesicular fraction

Method (Pharmacological Data)

vesicular fraction incubated with title comp. and 2 nmol/l <3H>DHTBZ for 4 h at 25 deg C; rapid filtration; liquid scintillation counting

Further Details (Pharmacological Data)

DHTBZ: dihydrotetrabenazine; VMAT2: vesicular monoamine transporter type 2; IC50 for title comp. inhibition of <3H>DHTBZ binding

Type (Pharmacological Data)

IC50

Value of Type (Pharmacological

> 100 μmol/l


Data)

162 of 317

163 of 317

164 of 317

Reference

Partilla, John S.; Dempsey, Allison G.; Nagpal, Ameet S.; Blough, Bruce E.; Baumann, Michael H.; Rothman, Richard B.

Journal of Pharmacology and Experimental Therapeutics, 2006 , vol. 319, # 1 p. 237 - 246 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

monoamine transporter; interaction with

Species or TestSystem (Pharmacological Data)

rat caudate putamen crude vesicular fraction

Method (Pharmacological Data)

vesicular fraction incubated with title comp. and 60 nmol/l <3H>dopamine for 5 min at 25 deg C; rapid filtration; liquid scintillation counting

Further Details (Pharmacological Data)

DHTBZ: dihydrotetrabenazine; VMAT2: vesicular monoamine transporter type 2; IC50 for title comp. inhibition of <3H>dopamine uptake

Type (Pharmacological Data)

IC50

Value of Type (Pharmacological Data)

3.29 μmol/l

Reference

Partilla, John S.; Dempsey, Allison G.; Nagpal, Ameet S.; Blough, Bruce E.; Baumann, Michael H.; Rothman, Richard B.

Journal of Pharmacology and Experimental Therapeutics, 2006 , vol. 319, # 1 p. 237 - 246 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

transmitter releasing

Species or TestSystem (Pharmacological Data)

rat caudate putamen crude vesicular fraction

Method (Pharmacological Data)

vesicular fraction preloaded with 60 nmol/l <3H>tyramine for 20 min at 25 deg C, incubated with title comp. for 2 min at 25 deg C; rapid filtration; liquid scintillation counting; <3H>tyramine release evaluated

Further Details (Pharmacological Data)

EC50 and EMAX for title comp. inhibition of <3H>tyramine release

Type (Pharmacological Data)

EC50

Value of Type (Pharmacological Data)

10.5 μmol/l

Results

EMAX = 95.8 percent

Reference

Partilla, John S.; Dempsey, Allison G.; Nagpal, Ameet S.; Blough, Bruce E.; Baumann, Michael H.; Rothman, Richard B.

Journal of Pharmacology and Experimental Therapeutics, 2006 , vol. 319, # 1 p. 237 - 246 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

transmitter releasing

Species or TestSystem (Pharmacological Data)

rat caudate putamen crude vesicular fraction

Method (Pharmacological Data)

vesicular fraction preloaded with 60 nmol/l <3H>dopamine for 20 min at 25 deg C, incubated with title comp. for 10 min at 25 deg C; rapid filtration; liquid scintillation counting; <3H>dopamine release evaluated

Further Details (Pharmacological Data)

EC50 and EMAX for title comp. inhibition of <3H>dopamine release

Type (Pharmacological Data)

EC50


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166 of 317

167 of 317

Value of Type (Pharmacological Data)

4.3 μmol/l

Results

EMAX = 65.7 percent

Reference

Partilla, John S.; Dempsey, Allison G.; Nagpal, Ameet S.; Blough, Bruce E.; Baumann, Michael H.; Rothman, Richard B.

Journal of Pharmacology and Experimental Therapeutics, 2006 , vol. 319, # 1 p. 237 - 246 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

accumulation; effect on

Species or TestSystem (Pharmacological Data)

human embryonic kidney 293 cells

Concentration (Pharmacological Data)

10 μmol/l

Method (Pharmacological Data)

cells were stably transfected with WT-hDAT; treated with title comp. intracellularly (20-60 min) using whole-cell patch clamp pipette; cellular distribution of WT-hDAT measured; membrane potentials recorded; intracellular fluorescence measured

Further Details (Pharmacological Data)

WT-hDAT: wild type-human dopamine transporter; control: vehicle; further study with Zn(2+) on the effect of title comp.; intracellular fluorescence measured to quantify dopamine transporter cell surface redistribution

Results

title comp. caused WT-hDAT to traffic away from membrane and accumulate intracellularly; title comp. produced significant increase in intracellular fluorescence at times between 20 and 60 min; Zn(2+) prevented the title comp. effect; diagrams, photos

Reference

Kahlig, Kristopher M.; Lute, Brandon J.; Wei, Yuqiang; Loland, Claus J.; Gether, Ulrik; Javitch, Jonathan A.; Galli, Aurelio

Molecular Pharmacology, 2006 , vol. 70, # 2 p. 542 - 548 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

accumulation; effect on

Species or TestSystem (Pharmacological Data)

human embryonic kidney 293 cells

Concentration (Pharmacological Data)

10 μmol/l

Method (Pharmacological Data)

cells stably transfected with Y335A-hDAT; treated with title comp. intracellularly (20-60 min) using whole-cell patch clamp pipette; cellular distribution of Y335A-hDAT measured; membrane potentials recorded; intracellular fluorescence measured

Further Details (Pharmacological Data)

hDAT: human dopamine transporter; Y335A-hDAT is a transporter mutant; control: vehicle; further study with Zn(2+) on the effect of title comp.; intracellular fluorescence measured to quantify dopamine transporter cell surface redistribution

Results

title comp. failed to cause cellular redistribution of Y335A-hDAT; intracellular fluorescence unchanged by title comp.; coapplication of title comp. and Zn(2+) led to increase in Y335A-hDAT intracellular pool; diagrams, photos

Reference

Kahlig, Kristopher M.; Lute, Brandon J.; Wei, Yuqiang; Loland, Claus J.; Gether, Ulrik; Javitch, Jonathan A.; Galli, Aurelio

Molecular Pharmacology, 2006 , vol. 70, # 2 p. 542 - 548 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

transporter expression; reduction of

Species or TestSystem (Pharmacological Data)

human embryonic kidney 293 cells

Concentration (Pharmacological Data)

10 μmol/l

Method (Pharmacological Data)

cells with/without Zn(2+) were treated with title comp. intracellularly (37 deg C, 1 h); cell surface biotinylation performed; biotinylated proteins, total cell lysates separated by SDS-PAGE; immunoblotted; biotinylated band densities quantified

Further Details (Pharmacological Data)

WT-hDAT: wild type-human dopamine transporter; control: vehicle

Results

title comp. treatment induced 46percent reduction in cell surface expression of wild type-human dopamine transporter compared with


control; coincubation of title comp. with Zn(2+) prevented title comp. effect; diagrams, photos

168 of 317

169 of 317

170 of 317

Reference

Kahlig, Kristopher M.; Lute, Brandon J.; Wei, Yuqiang; Loland, Claus J.; Gether, Ulrik; Javitch, Jonathan A.; Galli, Aurelio

Molecular Pharmacology, 2006 , vol. 70, # 2 p. 542 - 548 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

transporter expression; reduction of

Species or TestSystem (Pharmacological Data)

human embryonic kidney 293 cells

Concentration (Pharmacological Data)

10 μmol/l

Method (Pharmacological Data)

cells with/without Zn(2+) were treated with title comp. intracellularly (37 deg C, 1 h); cell surface biotinylation performed; biotinylated proteins, total cell lysates separated by SDS-PAGE; immunoblotted; biotinylated band densities quantified

Further Details (Pharmacological Data)

hDAT: human dopamine transporter; Y335A-hDAT is a transporter mutant; control: vehicle

Results

title comp. treatment did not reduce cell surface expression of Y335A-hDAT; coincubation with title comp. and Zn(2+) resulted in 27percent loss of cell surface Y335A-hDAT; diagram, photo

Reference

Kahlig, Kristopher M.; Lute, Brandon J.; Wei, Yuqiang; Loland, Claus J.; Gether, Ulrik; Javitch, Jonathan A.; Galli, Aurelio

Molecular Pharmacology, 2006 , vol. 70, # 2 p. 542 - 548 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

accumulation; effect on

Species or TestSystem (Pharmacological Data)

human embryonic kidney 293 cells

Concentration (Pharmacological Data)

10 μmol/l

Method (Pharmacological Data)

cells stably transfected with Y335A-hDAT were treated with title comp. intracellularly using whole-cell current-clamp pipette; after 20 min of perfusion, Y335A-hDAT intracellular fluorescence quantified using confocal imaging

Further Details (Pharmacological Data)

hDAT: human dopamine transporter; Y335A-hDAT is a transporter mutant; control: vehicle; reference: dopamine

Results

title comp. produced an increase in Y335A-hDAT intracellular fluorescence; photo, diagram

Reference

Kahlig, Kristopher M.; Lute, Brandon J.; Wei, Yuqiang; Loland, Claus J.; Gether, Ulrik; Javitch, Jonathan A.; Galli, Aurelio

Molecular Pharmacology, 2006 , vol. 70, # 2 p. 542 - 548 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

cytotoxicity

Species or TestSystem (Pharmacological Data)

PC12 cells

Kind of Dosing (Pharmacological Data)

chronic treatment with dose of 30 μM; acute dose was 1 mM

Method (Pharmacological Data)

cells cultured with non-toxic conc. of title comp. for 7-12 months and further incubated with acute dose of title comp. for 96 h; cell viability measured using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) reduction assay

Further Details (Pharmacological Data)

further investigations on dopaminergic system involvement by measurement of extra/intracellular dopamine (DA) levels and dihydroxyphenylacetic acid (DOPAC; DA metabolite) formation by HPCL; control: non-exposed to chronic title comp. cells

Results

title comp. induced the same decrease in cell viability (ca. 40percent) as control; no detectable levels of extra/intracellular DA or DOPAC were detected, indicating that DA was not involved in title comp. induced toxicity; fig.

Reference

Cunha-Oliveira, Teresa; Rego, A. Cristina; Morgadinho, Maria Teresa; Macedo, Tice; Oliveira, Catarina Resende

Toxicology, 2006 , vol. 217, # 1 p. 54 - 62 Title/Abstract Full Text View citing articles Show Details


171 of 317

172 of 317

173 of 317

174 of 317

Effect (Pharmacological Data)

oxidative stress injury; reduction of

Species or TestSystem (Pharmacological Data)

PC12 cells

Concentration (Pharmacological Data)

30 μmol/l

Method (Pharmacological Data)

cells cultured with non-toxic conc. of title comp. for 7-12 months and further incubated with H2O2 (75 μM) for 24 h; cell viability measured using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) reduction assay

Further Details (Pharmacological Data)

control: non-exposed to title comp. cells

Results

chronic title comp. treatment slightly protected cells from acute exposure to H2O2: decrease in cell viability was ca. 70percent compared with 80percent for control; fig.

Reference

Cunha-Oliveira, Teresa; Rego, A. Cristina; Morgadinho, Maria Teresa; Macedo, Tice; Oliveira, Catarina Resende

Toxicology, 2006 , vol. 217, # 1 p. 54 - 62 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

cytotoxicity

Species or TestSystem (Pharmacological Data)

PC12 cells

Concentration (Pharmacological Data)

1 mmol/l

Method (Pharmacological Data)

cells cultured with non-toxic conc. of H2O2 for 7-12 months and further incubated with title comp. for 96 h; cell viability measured using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) reduction assay

Further Details (Pharmacological Data)

control: non-exposed to chronic H2O2 cells

Results

title comp. toxicity was similar to toxicity of control cells, suggesting that title comp. toxic effect was independent of adaptive changes induced by oxidative stress; fig.

Reference

Cunha-Oliveira, Teresa; Rego, A. Cristina; Morgadinho, Maria Teresa; Macedo, Tice; Oliveira, Catarina Resende

Toxicology, 2006 , vol. 217, # 1 p. 54 - 62 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

dopamine release; induction of

Species or TestSystem (Pharmacological Data)

PC12 cells

Concentration (Pharmacological Data)

3 mmol/l

Method (Pharmacological Data)

cells cultured with title comp. for 24 h; extra/intracellular dopamine (DA) levels and dihydroxyphenylacetic acid (DOPAC; DA metabolite) formation assessed by HPLC

Further Details (Pharmacological Data)

control: untreated cells

Results

compared to control title comp. increased extracellular DA accumulation by 5.6-fold and led to decreases in intracellular DA (by 8.3-fold); fig.

Reference

Cunha-Oliveira, Teresa; Rego, A. Cristina; Morgadinho, Maria Teresa; Macedo, Tice; Oliveira, Catarina Resende

Toxicology, 2006 , vol. 217, # 1 p. 54 - 62 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

metabolism; inhibition of


175 of 317

Species or TestSystem (Pharmacological Data)

PC12 cells

Concentration (Pharmacological Data)

3 mmol/l

Method (Pharmacological Data)

cells cultured with title comp. for 24 h; dopamine metabolite (dihydroxyphenylacetic acid) formation assessed by HPLC

Further Details (Pharmacological Data)

control: untreated cells

Results

compared to control title comp. decreased dihydroxyphenylacetic acid level by 4.7-fold; fig.

Reference

Cunha-Oliveira, Teresa; Rego, A. Cristina; Morgadinho, Maria Teresa; Macedo, Tice; Oliveira, Catarina Resende

Toxicology, 2006 , vol. 217, # 1 p. 54 - 62 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

latency of different sleep states; effect on

Species or TestSystem (Pharmacological Data)

Sprague Dawley rat

Sex

male

Route of Application

intraperitoneal

Method (Pharmacological Data)

EXAMPLE STUDY PURPOSE:This study was undertaken to determine the effect of the (D) or (R) enantiomer of a phenylalkylamino carbamate of Formula I, specifically O- carbamoyl-(D)-phenylalaninol which can also be named (R)-(beta-amino- benzenepropyl) carbamate shown above as Formula Ib, referred to herein as "TEST COMPOUND" on the sleep-wake organization in rats after acute administration of test compound, in direct comparison to amphetamine and cocaine. EPO In order to characterize the profile of activity of TEST COMPOUND in sleep-wake organization in rats, animals were chronically implanted with electrodes for recording the cortical electroencephalogram, electrical neck muscle activity, and ocular movements, while whole body movement levels were simultaneously registered. Secondly, effects were compared with those obtained with two reference psychostimulant drugs, cocaine and amphetamine. Changes in sleep-wake organization can be reliably detected on the basis of such polysomnographic recordings. Subsequent analysis of the pattern of changes has been validated to predict the class of psychotropic agents to which the compound under investigation resembles best. (See, Ruigt, GS et al. (1993) Neuropsychobiology, 28(3):138-153)MATERIALS AND METHODS AnimalsThe experiments were carried out on male adult Sprague Dawley rats, supplied by Harlan (Borchen, Germany) weighing 240-26Og at time of surgery. Animals were housed in full-view Plexiglas cages (25x33x18 cm) that fit to IVC- racks (individually ventilated cages) located in a sound attenuated chamber. Rats were provided with a micro-chip for identification purposes and maintained under controlled environmental conditions throughout the study: 22 +/- 2°C ambient temperature, relative humidity at 60percent, 12:12 light-dark cycle (lights on from 12:00 hrs to 00:00 hrs; light intensity ~100 lux) with standard laboratory food chow and tap water available ad libitum. The institutional animal care and use committee approved all animal procedures.Surgery Under isoflurane inhalation anesthesia, the rats were mounted in a stereotaxic apparatus. The oval area of the scalp was removed, and the uncovered skull was cleared of the periosteum. Three small cavities were drilled into the cranial bone without perforating the dura to receive 3 fixing stainless steel screws (diameter 1 mm) for polygraphic recording of frontal and parietal electroencephalogram (EEG). Two electrodes were placed EPO stereotaxically on each side of the sagittal suture (AP + 2 mm, L - 2 mm;and AP - 6 mm, L 3 mm from Bregma, while the third (reference) electrode was screwed over the cerebellum. The incisor bar was -5 mm under the centre of the ear bar, according to the stereotactic atlas of Paxinos G. Watson C. The Rat Brain in Stereotaxic Coordinates, Academic Press, San Diego, CA, U.S.A. (1998).For the recording of the electro-oculogram (EOG) and electromyogram (EMG), stainless steel wires were placed in peri-orbital, and inserted into nuckal muscle, respectively. Electrodes (stainless steel wire, 7N51465T5TLT, 51/46 Teflon Bilaney, Germany) were connected to a pin (Future Electronics: 0672-2-15-15-30-27-10-0) with a small insert (track pins ; Dataflex: TRP-1558-0000) were fitted into a 8 holes connector. Finally, the electrodes were fixed with dental cement to the cranium. The animals were housed individually and were allowed to recover for at least one week.Sleep Recording Procedure and Pharmacological TestTen days after surgery, the animals were habituated for two weeks to the recording procedure in their home cages. The rats were connected at regular intervals with a cable to a rotating swivel allowing free movements while EEG, EOG and EMG activities were monitored.Only rats that complied with the required criteria were used at time of testing i.e. weight of animals 300-700 g, good polygraphical signal quality, a wash out period of at least 14 days in case of subject reuse, and no failure in t

Results

Results are given in table 1.

Location

Page/Page column 33-47

Reference

JANSSEN PHARMACEUTICA, N.V; AHNAOU, Abdallah; DRINKENBURG, Wilhelmus, H.I.M.; PALUMBO, Joseph; SPORN, Jonathan

Patent: WO2006/133393 A1, 2006 ; Title/Abstract Full Text Show Details

176 of 317

Effect (Pharmacological Data)

duration of different sleep states; effect on

Species or TestSystem (Pharmacological Data)

Sprague Dawley rat


Sex

male

Route of Application

intraperitoneal

Method (Pharmacological Data)

EXAMPLE STUDY PURPOSE:This study was undertaken to determine the effect of the (D) or (R) enantiomer of a phenylalkylamino carbamate of Formula I, specifically O- carbamoyl-(D)-phenylalaninol which can also be named (R)-(beta-amino- benzenepropyl) carbamate shown above as Formula Ib, referred to herein as "TEST COMPOUND" on the sleep-wake organization in rats after acute administration of test compound, in direct comparison to amphetamine and cocaine. EPO In order to characterize the profile of activity of TEST COMPOUND in sleep-wake organization in rats, animals were chronically implanted with electrodes for recording the cortical electroencephalogram, electrical neck muscle activity, and ocular movements, while whole body movement levels were simultaneously registered. Secondly, effects were compared with those obtained with two reference psychostimulant drugs, cocaine and amphetamine. Changes in sleep-wake organization can be reliably detected on the basis of such polysomnographic recordings. Subsequent analysis of the pattern of changes has been validated to predict the class of psychotropic agents to which the compound under investigation resembles best. (See, Ruigt, GS et al. (1993) Neuropsychobiology, 28(3):138-153)MATERIALS AND METHODS AnimalsThe experiments were carried out on male adult Sprague Dawley rats, supplied by Harlan (Borchen, Germany) weighing 240-26Og at time of surgery. Animals were housed in full-view Plexiglas cages (25x33x18 cm) that fit to IVC- racks (individually ventilated cages) located in a sound attenuated chamber. Rats were provided with a micro-chip for identification purposes and maintained under controlled environmental conditions throughout the study: 22 +/- 2°C ambient temperature, relative humidity at 60percent, 12:12 light-dark cycle (lights on from 12:00 hrs to 00:00 hrs; light intensity ~100 lux) with standard laboratory food chow and tap water available ad libitum. The institutional animal care and use committee approved all animal procedures.Surgery Under isoflurane inhalation anesthesia, the rats were mounted in a stereotaxic apparatus. The oval area of the scalp was removed, and the uncovered skull was cleared of the periosteum. Three small cavities were drilled into the cranial bone without perforating the dura to receive 3 fixing stainless steel screws (diameter 1 mm) for polygraphic recording of frontal and parietal electroencephalogram (EEG). Two electrodes were placed EPO stereotaxically on each side of the sagittal suture (AP + 2 mm, L - 2 mm;and AP - 6 mm, L 3 mm from Bregma, while the third (reference) electrode was screwed over the cerebellum. The incisor bar was -5 mm under the centre of the ear bar, according to the stereotactic atlas of Paxinos G. Watson C. The Rat Brain in Stereotaxic Coordinates, Academic Press, San Diego, CA, U.S.A. (1998).For the recording of the electro-oculogram (EOG) and electromyogram (EMG), stainless steel wires were placed in peri-orbital, and inserted into nuckal muscle, respectively. Electrodes (stainless steel wire, 7N51465T5TLT, 51/46 Teflon Bilaney, Germany) were connected to a pin (Future Electronics: 0672-2-15-15-30-27-10-0) with a small insert (track pins ; Dataflex: TRP-1558-0000) were fitted into a 8 holes connector. Finally, the electrodes were fixed with dental cement to the cranium. The animals were housed individually and were allowed to recover for at least one week.Sleep Recording Procedure and Pharmacological TestTen days after surgery, the animals were habituated for two weeks to the recording procedure in their home cages. The rats were connected at regular intervals with a cable to a rotating swivel allowing free movements while EEG, EOG and EMG activities were monitored.Only rats that complied with the required criteria were used at time of testing i.e. weight of animals 300-700 g, good polygraphical signal quality, a wash out period of at least 14 days in case of subject reuse, and no failure in t

Results

Results are given in table 2.

Location

Page/Page column 33-47

Reference

JANSSEN PHARMACEUTICA, N.V; AHNAOU, Abdallah; DRINKENBURG, Wilhelmus, H.I.M.; PALUMBO, Joseph; SPORN, Jonathan

Patent: WO2006/133393 A1, 2006 ; Title/Abstract Full Text Show Details

177 of 317

Effect (Pharmacological Data)

sleep parameter; effect on

Species or TestSystem (Pharmacological Data)

Sprague Dawley rat

Sex

male

Route of Application

intraperitoneal

Method (Pharmacological Data)

EXAMPLE STUDY PURPOSE:This study was undertaken to determine the effect of the (D) or (R) enantiomer of a phenylalkylamino carbamate of Formula I, specifically O- carbamoyl-(D)-phenylalaninol which can also be named (R)-(beta-amino- benzenepropyl) carbamate shown above as Formula Ib, referred to herein as "TEST COMPOUND" on the sleep-wake organization in rats after acute administration of test compound, in direct comparison to amphetamine and cocaine. EPO In order to characterize the profile of activity of TEST COMPOUND in sleep-wake organization in rats, animals were chronically implanted with electrodes for recording the cortical electroencephalogram, electrical neck muscle activity, and ocular movements, while whole body movement levels were simultaneously registered. Secondly, effects were compared with those obtained with two reference psychostimulant drugs, cocaine and amphetamine. Changes in sleep-wake organization can be reliably detected on the basis of such polysomnographic recordings. Subsequent analysis of the pattern of changes has been validated to predict the class of psychotropic agents to which the compound under investigation resembles best. (See, Ruigt, GS et al. (1993) Neuropsychobiology, 28(3):138-153)MATERIALS AND METHODS AnimalsThe experiments were carried out on male adult Sprague Dawley rats, supplied by Harlan (Borchen, Germany) weighing 240-26Og at time of surgery. Animals were housed in full-view Plexiglas cages (25x33x18 cm) that fit to IVC- racks (individually ventilated cages) located in a sound attenuated chamber. Rats were provided with a micro-chip for identification purposes and maintained under controlled environmental conditions throughout the study: 22 +/- 2°C ambient temperature, relative humidity at 60percent, 12:12 light-dark cycle (lights on from 12:00 hrs to 00:00 hrs; light intensity ~100 lux) with standard laboratory food chow and tap water available ad libitum. The institutional animal care and use committee approved all animal procedures.Surgery Under isoflurane inhalation anesthesia, the rats were mounted in a stereotaxic apparatus. The oval area of the scalp was removed, and the uncovered skull was cleared of the periosteum. Three small cavities were drilled into the cranial bone without perforating the dura to receive 3 fixing stainless steel screws (diameter 1 mm) for polygraphic recording of frontal and parietal electroencephalogram (EEG). Two electrodes were placed EPO stereotaxically on each side of the sagittal suture (AP + 2 mm, L - 2 mm;and AP - 6 mm, L 3 mm from Bregma, while the third (reference) electrode was screwed over the cerebellum. The incisor bar was -5 mm under the centre of the ear bar, according to the stereotactic atlas of Paxinos G. Watson C. The Rat Brain in Stereotaxic Coordinates, Academic Press, San Diego, CA, U.S.A. (1998).For the recording of the electro-oculogram (EOG) and electromyogram (EMG), stainless steel wires were placed in peri-orbital, and inserted into nuckal muscle, respectively. Electrodes (stainless steel wire, 7N51465T5TLT, 51/46 Teflon Bilaney, Germany) were connected to a pin (Future Electronics: 0672-2-15-15-30-27-10-0) with a small insert (track pins ; Dataflex: TRP-1558-0000) were fitted into a 8 holes connector. Finally, the electrodes were fixed with dental cement to the cranium. The animals were housed individually and were allowed to recover for at least one week.Sleep Recording Procedure and Pharmacological TestTen days after surgery, the animals were habituated for two weeks to the recording procedure in their


home cages. The rats were connected at regular intervals with a cable to a rotating swivel allowing free movements while EEG, EOG and EMG activities were monitored.Only rats that complied with the required criteria were used at time of testing i.e. weight of animals 300-700 g, good polygraphical signal quality, a wash out period of at least 14 days in case of subject reuse, and no failure in t Results

Results are given in table 3.

Location

Page/Page column 33-47

Reference

JANSSEN PHARMACEUTICA, N.V; AHNAOU, Abdallah; DRINKENBURG, Wilhelmus, H.I.M.; PALUMBO, Joseph; SPORN, Jonathan

Patent: WO2006/133393 A1, 2006 ; Title/Abstract Full Text Show Details

178 of 317

Effect (Pharmacological Data)

number of shifts from different sleep state; effect on

Species or TestSystem (Pharmacological Data)

Sprague Dawley rat

Sex

male

Route of Application

intraperitoneal

Method (Pharmacological Data)

EXAMPLE STUDY PURPOSE:This study was undertaken to determine the effect of the (D) or (R) enantiomer of a phenylalkylamino carbamate of Formula I, specifically O- carbamoyl-(D)-phenylalaninol which can also be named (R)-(beta-amino- benzenepropyl) carbamate shown above as Formula Ib, referred to herein as "TEST COMPOUND" on the sleep-wake organization in rats after acute administration of test compound, in direct comparison to amphetamine and cocaine. EPO In order to characterize the profile of activity of TEST COMPOUND in sleep-wake organization in rats, animals were chronically implanted with electrodes for recording the cortical electroencephalogram, electrical neck muscle activity, and ocular movements, while whole body movement levels were simultaneously registered. Secondly, effects were compared with those obtained with two reference psychostimulant drugs, cocaine and amphetamine. Changes in sleep-wake organization can be reliably detected on the basis of such polysomnographic recordings. Subsequent analysis of the pattern of changes has been validated to predict the class of psychotropic agents to which the compound under investigation resembles best. (See, Ruigt, GS et al. (1993) Neuropsychobiology, 28(3):138-153)MATERIALS AND METHODS AnimalsThe experiments were carried out on male adult Sprague Dawley rats, supplied by Harlan (Borchen, Germany) weighing 240-26Og at time of surgery. Animals were housed in full-view Plexiglas cages (25x33x18 cm) that fit to IVC- racks (individually ventilated cages) located in a sound attenuated chamber. Rats were provided with a micro-chip for identification purposes and maintained under controlled environmental conditions throughout the study: 22 +/- 2°C ambient temperature, relative humidity at 60percent, 12:12 light-dark cycle (lights on from 12:00 hrs to 00:00 hrs; light intensity ~100 lux) with standard laboratory food chow and tap water available ad libitum. The institutional animal care and use committee approved all animal procedures.Surgery Under isoflurane inhalation anesthesia, the rats were mounted in a stereotaxic apparatus. The oval area of the scalp was removed, and the uncovered skull was cleared of the periosteum. Three small cavities were drilled into the cranial bone without perforating the dura to receive 3 fixing stainless steel screws (diameter 1 mm) for polygraphic recording of frontal and parietal electroencephalogram (EEG). Two electrodes were placed EPO stereotaxically on each side of the sagittal suture (AP + 2 mm, L - 2 mm;and AP - 6 mm, L 3 mm from Bregma, while the third (reference) electrode was screwed over the cerebellum. The incisor bar was -5 mm under the centre of the ear bar, according to the stereotactic atlas of Paxinos G. Watson C. The Rat Brain in Stereotaxic Coordinates, Academic Press, San Diego, CA, U.S.A. (1998).For the recording of the electro-oculogram (EOG) and electromyogram (EMG), stainless steel wires were placed in peri-orbital, and inserted into nuckal muscle, respectively. Electrodes (stainless steel wire, 7N51465T5TLT, 51/46 Teflon Bilaney, Germany) were connected to a pin (Future Electronics: 0672-2-15-15-30-27-10-0) with a small insert (track pins ; Dataflex: TRP-1558-0000) were fitted into a 8 holes connector. Finally, the electrodes were fixed with dental cement to the cranium. The animals were housed individually and were allowed to recover for at least one week.Sleep Recording Procedure and Pharmacological TestTen days after surgery, the animals were habituated for two weeks to the recording procedure in their home cages. The rats were connected at regular intervals with a cable to a rotating swivel allowing free movements while EEG, EOG and EMG activities were monitored.Only rats that complied with the required criteria were used at time of testing i.e. weight of animals 300-700 g, good polygraphical signal quality, a wash out period of at least 14 days in case of subject reuse, and no failure in t

Results

Results are given in table 4.

Location

Page/Page column 33-47

Reference

JANSSEN PHARMACEUTICA, N.V; AHNAOU, Abdallah; DRINKENBURG, Wilhelmus, H.I.M.; PALUMBO, Joseph; SPORN, Jonathan

Patent: WO2006/133393 A1, 2006 ; Title/Abstract Full Text Show Details

179 of 317

Effect (Pharmacological Data)

enzyme; inhib. of

Species or TestSystem (Pharmacological Data)

DBA/2N/Kuo mouse liver microsomes CYP2A5

Sex

male and female

Method (Pharmacological Data)

enzymatic assay; coumarin used as a substrate; in the presence of NADPH; Tris-HCl buffer, pH 7.4; 37 deg C; 10 min incubation; coumarin 7-hydroxylation monitored by fluorescence measurements

Type (Pharmacological Data)

pIC50


180 of 317

181 of 317

182 of 317

Value of Type (Pharmacological Data)

2.85 dimensionless

Reference

Rahnasto, Minna; Raunio, Hannu; Poso, Antti; Wittekindt, Carsten; Juvonen, Risto O.

Journal of Medicinal Chemistry, 2005 , vol. 48, # 2 p. 440 - 449 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

enzyme; inhib. of

Species or TestSystem (Pharmacological Data)

human liver microsomes CYP2A6

Method (Pharmacological Data)

enzymatic assay; coumarin used as a substrate; in the presence of NADPH; Tris-HCl buffer, pH 7.4; 37 deg C; 10 min incubation; coumarin 7-hydroxylation monitored by fluorescence measurements

Type (Pharmacological Data)

pIC50

Value of Type (Pharmacological Data)

3.50 dimensionless

Reference

Rahnasto, Minna; Raunio, Hannu; Poso, Antti; Wittekindt, Carsten; Juvonen, Risto O.

Journal of Medicinal Chemistry, 2005 , vol. 48, # 2 p. 440 - 449 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

enzyme; inhib. of

Species or TestSystem (Pharmacological Data)

recombinant cytochrome P450 2C8

Concentration (Pharmacological Data)

30 μmol/l

Method (Pharmacological Data)

title comp. added to rhCYP2C8+substrate (ADQ)+NADPH mixture in phosphate buffer (pH 7.4) with MgCl2 and incubated at 37 deg C for 10 min; ADQ N-deethylase activity of rhCYP2C8 determined by measurement of N-desethylamodiaquine with HPLC/MS/MS

Further Details (Pharmacological Data)

rhCYP2C8: heterologously expressed recombinant CYP2C8; ADQ: amodiaquine

Results

title comp. inhibited enzyme by 11.2 percent

Reference

Walsky, Robert L.; Gaman, Emily A.; Obach, R. Scott

Journal of Clinical Pharmacology, 2005 , vol. 45, # 1 p. 68 - 78 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

behavioural symptoms

Species or TestSystem (Pharmacological Data)

Wistar-Kyoto rat

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

0.6 - 10 mg/kg

Method (Pharmacological Data)

after single title comp. injection, rat locomotor activity recorded in open-field cages continuously (sample time: 10 min) throughout 24 h cycle for 2 d

Further Details (Pharmacological Data)

control: saline

Results

title comp. at 0.6-2.5 mg/kg significantly dose-dependently increased locomotor activity, at 10 mg/kg had no effect on horizontal activity


but rather produced significant increase in stereotypic behavior

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Reference

Prieto-Gomez; Vazquez-Alvarez; Martinez-Pena; Reyes-Vazquez; Yang; Dafny

Life Sciences, 2005 , vol. 77, # 6 p. 635 - 649 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

synaptic currents; induction of

Species or TestSystem (Pharmacological Data)

Wister rat

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

2.5 - 20 mg/kg

Method (Pharmacological Data)

24 h after title comp. injection, rats sacrificed under anesthesia; brain removed and cut; spontaneous miniature exitatory post-synaptic currents recorded from horizontal midbrain slices using Axopatch 1D patch-clamp amplifier

Further Details (Pharmacological Data)

control: saline

Results

title comp. dose-dependently increased frequency and amplitude of miniature excitatory post-synaptic currents (figure)

Reference

Prieto-Gomez; Vazquez-Alvarez; Martinez-Pena; Reyes-Vazquez; Yang; Dafny

Life Sciences, 2005 , vol. 77, # 6 p. 635 - 649 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

synaptic currents; induction of

Species or TestSystem (Pharmacological Data)

Wister rat horisontal midbrain slice

Sex

male

Concentration (Pharmacological Data)

2.5 - 20 μmol/l

Method (Pharmacological Data)

brain slices placed in bath perfused with title comp.; spontaneous miniature exitatory post-synaptic currents recorded from brain slices comp. using Axopatch 1D patch-clamp amplifier

Further Details (Pharmacological Data)

control: saline

Results

title comp. dose-dependently increased frequency and amplitude of miniature excitatory post-synaptic currents (figure)

Reference

Prieto-Gomez; Vazquez-Alvarez; Martinez-Pena; Reyes-Vazquez; Yang; Dafny

Life Sciences, 2005 , vol. 77, # 6 p. 635 - 649 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

synaptic currents; induction of

Species or TestSystem (Pharmacological Data)

Wister rat brain slice

Sex

male

Concentration (Pharmacological Data)

2.5 - 20 μmol/l

Method (Pharmacological Data)

brain slices perfused with title comp. in bath; NMDA mediated exitatory post-synaptic currents recorded by whole-cell patch clamping from VTA-DA neurons following PFC afferent stimulation

Further Details (Pharmacological

NMDA: N-methyl-D-aspartate; VTA-DA: ventral tegmental areas dopaminergic; PFC: prefrontal cortex; control: saline


Data)

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Results

title comp. significantly increased NMDA mediated excitatory post-synaptic currents at high doses of 10.0 and 20.0 μmol/l (figure)

Reference

Prieto-Gomez; Vazquez-Alvarez; Martinez-Pena; Reyes-Vazquez; Yang; Dafny

Life Sciences, 2005 , vol. 77, # 6 p. 635 - 649 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

synaptic currents; effect on

Species or TestSystem (Pharmacological Data)

Wister rat

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

2.5 - 20 mg/kg

Method (Pharmacological Data)

24 h after title comp. injection, rats sacrificed under anesthesia; brain removed and cut; NMDA mediated exitatory post-synaptic currents recorded by whole-cell patch clamping from VTA-DA neurons following PFC afferent stimulation

Further Details (Pharmacological Data)

NMDA: N-methyl-D-aspartate; VTA-DA: ventral tegmental areas dopaminergic; PFC: prefrontal cortex; control: saline

Comment (Pharmacological Data)

No effect

Reference

Prieto-Gomez; Vazquez-Alvarez; Martinez-Pena; Reyes-Vazquez; Yang; Dafny

Life Sciences, 2005 , vol. 77, # 6 p. 635 - 649 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

synaptic currents; induction of

Species or TestSystem (Pharmacological Data)

Wister rat brain slices

Sex

male

Concentration (Pharmacological Data)

2.5 - 20 μmol/l

Method (Pharmacological Data)

brain slices perfused with title comp. in bath; AMPA mediated exitatory post-synaptic currents recorded by whole-cell patch clamping from VTA-DA neurons following PFC afferent stimulation

Further Details (Pharmacological Data)

AMPA: α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; VTA-DA: ventral tegmental areas dopaminergic; PFC: prefrontal cortex; control: saline

Results

title comp. significantly increased AMPA mediated excitatory post-synaptic currents at doses of 5.0 - 20.0 μmol/l by 14.10 - 23.71 percent, resp. (figure)

Reference

Prieto-Gomez; Vazquez-Alvarez; Martinez-Pena; Reyes-Vazquez; Yang; Dafny

Life Sciences, 2005 , vol. 77, # 6 p. 635 - 649 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

synaptic currents; induction of

Species or TestSystem (Pharmacological Data)

Wister rat

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological

2.5 - 20 mg/kg


Data)

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Method (Pharmacological Data)

24 h after title comp. injection, rats sacrificed under anesthesia; brain removed and cut; AMPA mediated exitatory post-synaptic currents recorded by whole-cell patch clamping from VTA-DA neurons following PFC afferent stimulation

Further Details (Pharmacological Data)

AMPA: α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; VTA-DA: ventral tegmental areas dopaminergic; PFC: prefrontal cortex; control: saline

Results

title comp. significantly increased AMPA mediated excitatory post-synaptic currents at doses of 10 and 20.0 mg/kg (figure)

Reference

Prieto-Gomez; Vazquez-Alvarez; Martinez-Pena; Reyes-Vazquez; Yang; Dafny

Life Sciences, 2005 , vol. 77, # 6 p. 635 - 649 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

gene expression; induction of

Species or TestSystem (Pharmacological Data)

Chinese hamster ovary cells

Concentration (Pharmacological Data)

10 μmol/l

Method (Pharmacological Data)

cells incubated with title comp. for 18 h; 1 μmol/l isoprenaline or 10 μmol/l forskolin added; reaction substrate PNPP added, incubated 1 h at 37 deg C; activity of secreted placental alkaline phosphatase (SPAP) measured spectrophotometrically

Further Details (Pharmacological Data)

cells transfected with human β2 adrenoceptor and SPAP reporter gene with multiple cAMP response elements in promoter region; PNPP: p-nitrophenol phosphate

Results

title comp. significantly potentiated isoprenaline- and forskolin-stimulated SPAP production (to 171.23 percent for isoprenaline stimulation)

Reference

Richards; Abdel-Razaq; Bates; Kendall

Biochemical Pharmacology, 2005 , vol. 70, # 5 p. 762 - 769 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

induction of hyper-locomotion

Species or TestSystem (Pharmacological Data)

rat

Method (Pharmacological Data)

In vivo test: Behaviour Behavioural activity was measured using eight Digiscan activity monitors (RXYZM (16) TAO, Omnitech Electronics, Columbus, OH, USA), connected to an Omnitech Digiscan analyzer and a Apple Macintosh computer equipped with a digital interface board (NB DIO- 24, National Instruments, USA). Each activity monitor consisted of a quadratic metal frame (WxL 40x40 cm) equipped with photobeam sensors. During measurements of behavioural activity, a rat was put in a transparent acrylic cage (WxLxH, 40x40x30 cm) which in turn was placed in the activity monitor. Each activity monitor was equipped with three rows of infrared photobeam sensors, each row consisting of 16 sensors. Two rows were placed along the front and the side of the floor of the cage, at a 90° angle, and the third row was placed 10 cm above the floor to measure vertical activity. Photobeam sensors were spaced 2.5 cm apart. Each activity monitor was fitted in an identical sound and light attenuating box containing a weak house light and a fan. The computer software was written using object oriented programming (LabVIEWNo., National instruments, Austin, TX, USA). Behavioural data from each activity monitor, representing the position (horizontal centre of gravity and vertical activity) of the animal at each time, were recorded at a sampling frequency of 25 Hz and collected using a custom written LABViewNo. application. The data from each recording session were stored and analyzed with respect to distance traveled. Each behavioural recording session lasted 60 min, starting approximately 4 min after the injection of test compound. Similar behavioural recording procedures were applied for drug-naive and drug pre-treated rats. Rats pretreated with d-amphetamine were given a dose of 1.5 mg/kg i.p.. 10 min before the recording session in the activity monitor. Rats pretreated with MK-801 were given a dose of 0.7 mg/kg i.p.. 90 min before the recording session in the activity monitor. The results are presented as counts/60 minutes, or counts/30 minutes, in arbitrary length units. Statistical comparisons were carried out using student's t-test vs the control group. In MK-801 or amphetamine pre-treated animals, statistical comparisons were made vs the MK801 or d-amphetamine controls, respectively. EDso values for reduction of amphetamine-induced hyper-locomotion are calculated by curve fitting. For most compounds, the evaluation is based on 16 amphetamine pre- treated animals over the dose range 0,11, 33 and 100 μmol/kg s. c. in one single experiment, with complementary doses in separate experiments. Calculations are based on distance during the last 45 minutes of one hour of measurement. The distances are normalised to amphetamine-control and fitted by least square minimization to the function "End-(End-Control)/(1+ (dose/ED50)Slope)". The four parameters are fitted with the restrictions: ED50>0,0.50percent of control. To estimate confidence levels for the parameters, the fit is repeated 100 times with a random evenly distributed squared weight (0 to 1) for every measurement value. Presented EDso-ranges cover 95percent of these values; Table 4. Effects of compounds in the present invention on reduction of amphetamine- induced hyper-locomotion. Comparative examples from prior art is also included. For methods and statistical calculations see the enclosed tests.

Results

The title compound was used for the induction of hyper.locomotion for testing examined compounds.

Location

Page/Page column 17; 32-33

Reference

A. CARLSSON RESEARCH AB

Patent: WO2005/121092 A1, 2005 ; Title/Abstract Full Text Show Details


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Effect (Pharmacological Data)

symptoms related to a viral infection; decrease of

Species or TestSystem (Pharmacological Data)

human

Route of Application

peroral

Method (Pharmacological Data)

EXAMPLE It has been unexpectedly determined that a person who was regularly taking ADDERALL prescribed by a doctor for ADD (Attention Deficit Disorder) exhibited symptoms related to a viral infection that included headache, runny nose, coughing. This person was associated with a variety of other individuals who also exhibited similar symptoms. The person missed some dosages of the prescribed ADDERALL. Upon ingesting the recommended dosage of the ADDERALL, the person, within one hour, experienced complete relief of the runny nose, cough, and sinus and chest congestion. However, the symptoms would reappear upon skipping the prescribed dosage of ADDERALL.

Results

Upon ingesting the recommended dosage of the title compound, the person, within one hour, experienced complete relief of the runny nose, cough, and sinus and chest congestion.

Location

Page/Page column 2

Reference

Wasson, Allan Anthony

Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details

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Effect (Pharmacological Data)

transmitter releasing

Species or TestSystem (Pharmacological Data)

rat pheochromocytoma PC12 cells

Concentration (Pharmacological Data)

1 μmol/l

Kind of Dosing (Pharmacological Data)

pretreatment with title comp. for 5 min a day during 5 d; 10 d later test dose given

Method (Pharmacological Data)

cells grown in DMEM during title comp. pretreatment; 10 d later incubation with title comp. in Krebs-Ringer bicarbonate buffer with or without 1.2 mmol/l CaCl2 for 2.5 min; dopamine (DA) in samples analysed by HPLC with electrochemical detection

Further Details (Pharmacological Data)

DMEM: Dulbecco's modified Eagle's medium; HPLC: high-pressure liquid chromatography; control: vehicle; further investigations with Ca(2+) channel blockers, tetanus toxin, reserpine, calmodulin kinase II inhibitor (KN-93), and protein kinase C inhibitor

Results

title comp. induced DA efflux from cells; this effect was Ca(2+)-dependently enhanced after title comp. pretreatment; DA efflux induction was inhibited by protein kinase C inhibitor, while Ca(2+) channel blockers and KN-93 inhibited only enhancement

Reference

Kantor; Zhang; Guptaroy; Park; Gnegy, Margaret E.

Journal of Pharmacology and Experimental Therapeutics, 2004 , vol. 311, # 3 p. 1044 - 1051 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

intracellular Ca(2+); increase of

Species or TestSystem (Pharmacological Data)

rat pheochromocytoma PC12 cells

Concentration (Pharmacological Data)

1 μmol/l

Kind of Dosing (Pharmacological Data)

pretreatment with title comp. for 5 min a day during 5 d; 10 d later test dose of title comp. given

Method (Pharmacological Data)

cells grown in DMEM during title comp. pretreatment; 10 d later cells resuspended in KRB buffer with or without 1.2 mmol/l CaCl2 and loaded with fura-2/AM; intracellular Ca(2+) measured in presence of title comp. at 37 deg C; spectrofluorometry

Further Details (Pharmacological Data)

DMEM: Dulbecco's modified Eagle's medium; AM: acetoxymethyl ester; KRB: Krebs-Ringer bicarbonate; control: vehicle; reference comp.: bradykinin (BK); further investigations with L- and N-type Ca(2+) channel blockers and desipramine (DP)

Results

title comp. Ca(2+)-independently increased cellular Ca(2+) similarly to BK; effect of title comp., but not of BK, was enhanced by title


comp. pretreatment; absence of Ca(2+) and Ca(2+) channel blockers prevented enhancement, while DP blocked all effects

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Reference

Kantor; Zhang; Guptaroy; Park; Gnegy, Margaret E.

Journal of Pharmacology and Experimental Therapeutics, 2004 , vol. 311, # 3 p. 1044 - 1051 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

enzyme; inhib. of

Species or TestSystem (Pharmacological Data)

rat pheochromocytoma PC12 cells

Concentration (Pharmacological Data)

1 μmol/l

Kind of Dosing (Pharmacological Data)

pretreatment with title comp. for 5 min a day during 5 d; 10 d later test dose of title comp. given; dissolved in saline

Method (Pharmacological Data)

cells grown in DMEM during title comp. pretreatment; 10 d later cells resuspended in KRB buffer and incubated with title comp. for 2.5 min; CaM kinase II activity measured in cell homogenate using autocamtide as a substrate and <γ-32P>ATP

Further Details (Pharmacological Data)

DMEM: Dulbecco's modified Eagle's medium; KRB: Krebs-Ringer bicarbonate; CaM: calmodulin; control: vehicle; further investigations using sulpiride

Results

title comp. inhibited CaM kinase II activity in vehicle-pretreated, but not in title comp.-pretreated cells; it was not affected by sulpiride; title comp. pretreatment caused no difference in CaM kinase activity without title comp. challenge

Reference

Kantor; Zhang; Guptaroy; Park; Gnegy, Margaret E.

Journal of Pharmacology and Experimental Therapeutics, 2004 , vol. 311, # 3 p. 1044 - 1051 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

transport

Species or TestSystem (Pharmacological Data)

rat pheochromocytoma PC12 cells

Concentration (Pharmacological Data)

1 μmol/l

Kind of Dosing (Pharmacological Data)

treatment with title comp. for 5 min a day during 5 d

Method (Pharmacological Data)

cells grown in DMEM during title comp. treatment; 10 d later cells harvested, placed in tubes, and eqilibrated at 37 deg C; uptake of 50 nmol/l or 1 μmol/l <3H>dopamine measured in Krebs-Ringer bicarbonate buffer with or without 1.2 mmol/l CaCl2

Further Details (Pharmacological Data)

DMEM: Dulbecco's modified Eagle's medium; control: vehicle

Comment (Pharmacological Data)

No effect

Reference

Kantor; Zhang; Guptaroy; Park; Gnegy, Margaret E.

Journal of Pharmacology and Experimental Therapeutics, 2004 , vol. 311, # 3 p. 1044 - 1051 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

metabolic

Species or TestSystem (Pharmacological Data)

rat pheochromocytoma PC12 cells

Concentration (Pharmacological Data)

1 μmol/l

Kind of Dosing (Pharmacological Data)

treatment with title comp. for 5 min a day during 5 d


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Method (Pharmacological Data)

cells grown in Dulbecco's modified Eagle's medium during title comp. treatment; 10 d later cellular dopamine content determined

Further Details (Pharmacological Data)

control: vehicle; further investigation using tetanus toxin and reserpine

Comment (Pharmacological Data)

No effect

Reference

Kantor; Zhang; Guptaroy; Park; Gnegy, Margaret E.

Journal of Pharmacology and Experimental Therapeutics, 2004 , vol. 311, # 3 p. 1044 - 1051 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

protease resistance; induction of

Species or TestSystem (Pharmacological Data)

Sprague-Dawley rat striatal membranes

Sex

male

Concentration (Pharmacological Data)

10 μmol/l

Method (Pharmacological Data)

membrane (DAT) incubated with title comp., followed by digestion with trypsin for 10 min at 22 deg C, then subjected to electrophoresis and immunoblotting with mAb 16

Further Details (Pharmacological Data)

mAb: monoclonal antibody; DAT: dopamine transporter; EL: extracellular loop

Comment (Pharmacological Data)

No effect

Reference

Gaffaney, Jon D.; Vaughan, Roxanne A.

Molecular Pharmacology, 2004 , vol. 65, # 3 p. 692 - 701 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

ligand binding; inhibition of

Species or TestSystem (Pharmacological Data)

Sprague-Dawley rat

Sex

male

Route of Application

subcutaneous

Concentration (Pharmacological Data)

2 - 8 mg/kg

Kind of Dosing (Pharmacological Data)

dissolved in saline

Method (Pharmacological Data)

20 min after title comp. administration <3H>raclopride was injected i.v.; 30 min later striata and cerebella were removed separately, solubilized, and counted; specific binding to D2 was estimated as the ratio of radioactivity striatum/cerebellum

Further Details (Pharmacological Data)

D2 = dopamine receptors; control: vehicle; the cerebellum was investigated to estimate the nonspecific binding

Results

title comp. decreased the specific binding of <3H>raclopride dose-dependently; the decrease was significant at 8 mg/kg title comp. (diagram)

Reference

Sun; Ginovart; Ko; Seeman; Kapur

Molecular Pharmacology, 2003 , vol. 63, # 2 p. 456 - 462 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

ligand binding; inhibition of


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Species or TestSystem (Pharmacological Data)

Sprague-Dawley rat

Sex

male

Route of Application

subcutaneous

Concentration (Pharmacological Data)

8 mg/kg

Kind of Dosing (Pharmacological Data)

dissolved in saline

Method (Pharmacological Data)

rats were sacrificed 1 - 6 h after title comp. administration; 30 min before sacrifice <3H>raclopride was injected i.v.; striata and cerebella were removed separately, solubilized, and counted

Further Details (Pharmacological Data)

specific binding to D2 was estimated as the ratio of radioactivity striatum/cerebellum; the cerebellum was investigated to estimate the nonspecific binding; D2 = dopamine receptors; control: vehicle

Results

title comp. decreased the specific binding of <3H>raclopride time-dependently; the decrease was significant at all time points (diagram)

Reference

Sun; Ginovart; Ko; Seeman; Kapur

Molecular Pharmacology, 2003 , vol. 63, # 2 p. 456 - 462 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

ligand binding; inhibition of

Species or TestSystem (Pharmacological Data)

Sprague-Dawley rat

Sex

male

Route of Application

subcutaneous

Concentration (Pharmacological Data)

8 mg/kg

Kind of Dosing (Pharmacological Data)

dissolved in saline

Method (Pharmacological Data)

rats were sacrificed 50 min after title comp. administration; membrane homogenate from one striatum side (left or right) was used for <3H>raclopride, and the other for <3H>spiperone binding assays; filter-bound radioactivity was counted

Further Details (Pharmacological Data)

dopamine D2 receptors were invest.; nonspecific binding was defined with 10 μmol/l (S)-sulpiride; control: vehicle; further invest. performed after preincubation of membranes with 200 μmol/l 5'-guanylylimidodiphosphate (GPP(NH)p) for 60 min

Results

title comp. decreased the <3H>raclopride but not <3H>spiperone binding; the effect of title comp. was caused by a decrease in D2receptor density, whereas Kd was unchanged; pretreatment with GPP(NH)p did not alter the effect of title comp. (tables)

Reference

Sun; Ginovart; Ko; Seeman; Kapur

Molecular Pharmacology, 2003 , vol. 63, # 2 p. 456 - 462 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

ligand binding; inhibition of

Species or TestSystem (Pharmacological Data)

Sprague-Dawley rat

Sex

male

Route of Application

subcutaneous

Concentration (Pharmacological Data)

8 mg/kg

Kind of Dosing

dissolved in saline


(Pharmacological Data)

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Method (Pharmacological Data)

rats were sacrificed 50 min after title comp. administration; striata were homogenized and fractioned by centrifugation; fractions were assayed for <3H>raclopride or <3H>spiperone specific binding; filter-bound radioactivity was counted

Further Details (Pharmacological Data)

dopamine D2 receptors were invest.; nonspecific binding was defined with 10 μmol/l (S)-sulpiride; control: vehicle

Results

treatment with title comp. significantly reduced the binding of <3H>raclopride in the total homogenate, the nuclear, and the mitochondrial fractions, whereas <3H>spiperone binding was only reduced in the mitochondrial fraction (diagram)

Reference

Sun; Ginovart; Ko; Seeman; Kapur

Molecular Pharmacology, 2003 , vol. 63, # 2 p. 456 - 462 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

ligand binding; inhibition of

Species or TestSystem (Pharmacological Data)

Sprague-Dawley rat

Sex

male

Route of Application

subcutaneous

Concentration (Pharmacological Data)

8 mg/kg

Kind of Dosing (Pharmacological Data)

dissolved in saline

Method (Pharmacological Data)

rats were sacrificed 50 min after title comp. administration; striatum membrane homogenates were used for competition binding study of 2 nmol/l <3H>raclopride in the presence 1E-12 - 1E-3 mol/l dopamine; room temp.; filter-bound radioactivity counted

Further Details (Pharmacological Data)

dopamine D2 receptors were investigated; control: vehicle

Results

treatment with title comp. caused a loss of high-affinity state D2 receptors (conc.-binding curve)

Reference

Sun; Ginovart; Ko; Seeman; Kapur

Molecular Pharmacology, 2003 , vol. 63, # 2 p. 456 - 462 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

cytotoxicity

Species or TestSystem (Pharmacological Data)

rat hepatoma-derived Fa32 cells

Kind of Dosing (Pharmacological Data)

applied as sulphate via complete culture medium

Method (Pharmacological Data)

cultured in Dulbecco's modified Eagle's medium; cells treated 24 h after seeding in microtitre plate (adhered cells) or immediately after seeding (adhering cells); cytotoxicity det. through inhibition of neutral red uptake

Further Details (Pharmacological Data)

control - culture medium; NI50 - 50 percent neutral red uptake inhibition

Type (Pharmacological Data)

NI50

Value of Type (Pharmacological Data)

1.23 - 1.66 mmol/l

Results

NI50 for adhered cells was 1.66 mmol/l; for adhering cells was 1.23 mmol/l

Reference

Dierickx, Paul J.; Scheers, Ellen M.

Journal of Applied Toxicology, 2002 , vol. 22, # 1 p. 61 - 65 Title/Abstract Full Text View citing articles Show Details


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Effect (Pharmacological Data)

transmitter releasing

Species or TestSystem (Pharmacological Data)

PC12 cells

Concentration (Pharmacological Data)

1 μmol/l

Kind of Dosing (Pharmacological Data)

daily, for 5 min

Method (Pharmacological Data)

cells treated with title comp. for 5 days, followed by 10 drug-free days; cells washed; challenged with amphetamine (AMP, 0.2-100 μmol/l, 2.5-min bolus); dopamine eluted; dopamine levels measured by high pressure liguid chromatography

Further Details (Pharmacological Data)

further investigation in presence of nerve growth factor and challenge with 1 μmol/l AMP; vehicle control; Ka: kinetic constant

Results

repeated, intermittent treatment with title comp. elicited increase in Vmax (ca. 2-fold vs. control) for AMP-mediated dopamine release without change in Ka; effect was not changed in presence of nerve growth factor (figures)

Reference

Kantor, Lana; Park, Yang Hae; Wang, Kevin K.W; Gnegy, Margaret E

European Journal of Pharmacology, 2002 , vol. 451, # 1 p. 27 - 35 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

transmitter releasing

Species or TestSystem (Pharmacological Data)

human neuroblastoma SH-SY5Y cells

Concentration (Pharmacological Data)

1 μmol/l

Kind of Dosing (Pharmacological Data)

daily, for 5 min

Method (Pharmacological Data)

cells treated with title comp. for 5 days, followed by 10 drug-free days; cells washed; challenged with amphetamine (AMP, 1 μmol/l, 2.5min bolus); dopamine eluted; dopamine levels measured by high pressure liguid chromatography

Further Details (Pharmacological Data)

vehicle control

Results

repeated, intermittent treatment with title comp. elicited increase in AMP-mediated dopamine release by 32-fold vs. 17-fold increase in control (figure)

Reference

Kantor, Lana; Park, Yang Hae; Wang, Kevin K.W; Gnegy, Margaret E

European Journal of Pharmacology, 2002 , vol. 451, # 1 p. 27 - 35 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

transmitter releasing

Species or TestSystem (Pharmacological Data)

PC12 cells

Concentration (Pharmacological Data)

1 μmol/l

Kind of Dosing (Pharmacological Data)

daily, for 5 min

Method (Pharmacological Data)

cells treated with title comp. for 5 days, followed by 0-10 drug-free days; cells washed; challenged with amphetamine (AMP, 1 μmol/l, 2.5-min bolus); dopamine eluted; dopamine levels measured by high pressure liguid chromatography

Further Details (Pharmacological Data)

vehicle control


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Results

repeated, intermittent treatment with title comp. elicited increase in AMP-mediated dopamine release after 6 days of withdrawal and significantly increased after 10 days of withdrawal (figure)

Reference

Kantor, Lana; Park, Yang Hae; Wang, Kevin K.W; Gnegy, Margaret E

European Journal of Pharmacology, 2002 , vol. 451, # 1 p. 27 - 35 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

transmitter releasing

Species or TestSystem (Pharmacological Data)

PC12 cells

Concentration (Pharmacological Data)

1 μmol/l

Kind of Dosing (Pharmacological Data)

continuously present in media

Method (Pharmacological Data)

cells treated with title comp. for 5 days, followed by 10 drug-free days; washed; challenged with amphetamine (1 μmol/l, 2.5-min bolus); dopamine eluted; dopamine levels measured by high pressure liguid chromatography

Further Details (Pharmacological Data)

vehicle control

Comment (Pharmacological Data)

No effect

Reference

Kantor, Lana; Park, Yang Hae; Wang, Kevin K.W; Gnegy, Margaret E

European Journal of Pharmacology, 2002 , vol. 451, # 1 p. 27 - 35 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

uptake; effect on

Species or TestSystem (Pharmacological Data)

PC12 cells

Concentration (Pharmacological Data)

1 μmol/l

Kind of Dosing (Pharmacological Data)

daily, for 5 min

Method (Pharmacological Data)

cells treated with title comp. for 5 days, followed by 10 drug-free days; specific dopamine uptake measured with 70 nmol/l and 1 μmol/l <3H>dopamine at 1 min using nisoxetin (100 nmol/l); filter-bound radioactivity measured by scintillation counter

Further Details (Pharmacological Data)

vehicle control

Comment (Pharmacological Data)

No effect

Reference

Kantor, Lana; Park, Yang Hae; Wang, Kevin K.W; Gnegy, Margaret E

European Journal of Pharmacology, 2002 , vol. 451, # 1 p. 27 - 35 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

uptake; effect on

Species or TestSystem (Pharmacological Data)

human neuroblastoma SH-SY5Y cells

Concentration (Pharmacological Data)

1 μmol/l

Kind of Dosing

daily, for 5 min


(Pharmacological Data)

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Method (Pharmacological Data)

cells treated with title comp. for 5 days, followed by 10 drug-free days; specific dopamine uptake measured with 70 nmol/l and 1 μmol/l <3H>dopamine at 1 min using nisoxetin (100 nmol/l); filter-bound radioactivity measured by scintillation counter

Further Details (Pharmacological Data)

vehicle control

Comment (Pharmacological Data)

No effect

Reference

Kantor, Lana; Park, Yang Hae; Wang, Kevin K.W; Gnegy, Margaret E

European Journal of Pharmacology, 2002 , vol. 451, # 1 p. 27 - 35 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

gene expression; effect on

Species or TestSystem (Pharmacological Data)

PC12 cells

Concentration (Pharmacological Data)

1 μmol/l

Kind of Dosing (Pharmacological Data)

daily, for 5 min

Method (Pharmacological Data)

cells treated with title comp. for 5 days, followed by 10 drug-free days; cells lysates analyzed for norepinephrine transporter density by immunoblotting

Further Details (Pharmacological Data)

vehicle control

Comment (Pharmacological Data)

No effect

Reference

Kantor, Lana; Park, Yang Hae; Wang, Kevin K.W; Gnegy, Margaret E

European Journal of Pharmacology, 2002 , vol. 451, # 1 p. 27 - 35 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

gene expression; effect on

Species or TestSystem (Pharmacological Data)

PC12 cells

Kind of Dosing (Pharmacological Data)

daily, for 5 min

Method (Pharmacological Data)

cells treated with title comp. for 5 days, followed by 10 drug-free days; cells lysates analyzed for dopamine transporter density by immunoblotting

Further Details (Pharmacological Data)

vehicle control

Comment (Pharmacological Data)

No effect

Reference

Kantor, Lana; Park, Yang Hae; Wang, Kevin K.W; Gnegy, Margaret E

European Journal of Pharmacology, 2002 , vol. 451, # 1 p. 27 - 35 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

gene expression; effect on

Species or TestSystem

PC12 cells


(Pharmacological Data)

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Concentration (Pharmacological Data)

1 μmol/l

Method (Pharmacological Data)

cells pretreated with title comp., incubated with 10 μmol/l cocaine for 10 min; <3H>nisoxetine at 30 nmol/l added to whole cells for 30 min; expression of norepinephrine transporter as filter-bound radioactivity counted using scintillation counter

Further Details (Pharmacological Data)

vehicle control

Comment (Pharmacological Data)

No effect

Reference

Kantor, Lana; Park, Yang Hae; Wang, Kevin K.W; Gnegy, Margaret E

European Journal of Pharmacology, 2002 , vol. 451, # 1 p. 27 - 35 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

free radical generation; induction of

Species or TestSystem (Pharmacological Data)

polymorphonuclear leukocytes

Concentration (Pharmacological Data)

50 μmol/l

Method (Pharmacological Data)

leukocytes incubated with 0.01 mol/l lucigenin in polystyrene vial; chemiluminescence was read for one min; title comp. or PMA (50 nmol/l) added; measurement of chemiluminescence was repeated in 25 min at 37 deg C with a luminometer

Further Details (Pharmacological Data)

control: vehicle; PMA: phorbol myristate acetate; PMA was used to test the functional viability of the isolated polymorphonuclear leukocytes

Results

title comp. signif. enhanced the chemiluminescence generation by 152 percent as compared with its baseline value; combination of title comp. with PMA increased chemiluminescence by 360 percent; fig.

Reference

Huang, Kun-Lun; Shaw, Kai-Ping; Wang, David; Hsu, Kang; Huang, Tze-Shung; Chen, Hsing-I

Life Sciences, 2002 , vol. 71, # 11 p. 1237 - 1244 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pneumotoxicity

Species or TestSystem (Pharmacological Data)

SD rats lung

Sex

male

Concentration (Pharmacological Data)

10 - 50 μmol/l

Method (Pharmacological Data)

isolated lung equillibrated in physiological salt soln., 10 min; title comp. added to perfusate; pulmonary arterial pressure and lung weight (LW) monitored continuously for 60 min; filteration coefficient (Kf) measured gravimetrically

Further Details (Pharmacological Data)

control: without title comp.; further effects of dimethylthiourea (DMTU) on title comp. studied

Results

title comp. induced pulmonary hypertension dose-dependently; causes signif. gain in LW; increased Kf by 90, 210 percent at 10, 50 μmol/l, resp.; title comp. induced hypertension and LW gain were attenuated and completely abolished, resp. by DMTU; diagrams

Reference

Huang, Kun-Lun; Shaw, Kai-Ping; Wang, David; Hsu, Kang; Huang, Tze-Shung; Chen, Hsing-I

Life Sciences, 2002 , vol. 71, # 11 p. 1237 - 1244 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

neuroregulatoric

Endpoint of Effect (Pharmacological Data)

DA extracellular concentration


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Species or TestSystem (Pharmacological Data)

Long-Evans rat

Sex

male and female

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

1 mg/kg

Kind of Dosing (Pharmacological Data)

applied as sulfate; in artificial cerebrospinal fluid (CSF); single injection

Method (Pharmacological Data)

Pb- or Na-exposed rats were placed in a stereotaxic frame; transversal dialysis probe was inserted into NAC of anesthetised rats; samples were collected every 20 min for 120 min after title comp. injection; HPLC

Further Details (Pharmacological Data)

nucleus accumbens (NAC); rats were continuously exposed to Pb (350 ppm) or Na (350 ppm) acetates in drinking water from early gestational day (2-6; "in utero") or from 28 days ("adult") of age; rats were used in the study at the 13th week of age

Results

title comp. induced dopamine release in NAC of rats; rats treated with Pb "in utero" responded with a lower dopamine release than rats treated "in utero" with Na; no sign. differences in the groups of rats treated "adult" were obs.; graphic represent.

Reference

Devoto, Paola; Flore, Giovanna; Ibba, Antonio; Fratta, Walter; Pani, Luca

Toxicology Letters, 2001 , vol. 121, # 3 p. 199 - 206 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

hypertensive

Species or TestSystem (Pharmacological Data)

Sprague-Dawley rat

Sex

male

Route of Application

intravenous

Concentration (Pharmacological Data)

2 mg/kg

Method (Pharmacological Data)

302 animals (253-352 g); 12/12 h light/dark cycle; food and water ad libitum; blood pressure

Comment (Pharmacological Data)

No effect

Reference

Chang; Pan; Lin

British Journal of Pharmacology, 2001 , vol. 132, # 7 p. 1524 - 1530 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

hypertensive

Species or TestSystem (Pharmacological Data)

Sprague-Dawley rat

Sex

male

Route of Application

intracutaneous

Concentration (Pharmacological Data)

0.1 - 0.3 mg

Method (Pharmacological Data)

302 animals (253-352 g); 12/12 h light/dark cycle; food and water ad libitum; blood pressure

Results

concentration dependent increase in mean arterial pressure; at 0.3 mg increase of 39 mmHg

Reference

Chang; Pan; Lin


British Journal of Pharmacology, 2001 , vol. 132, # 7 p. 1524 - 1530 Title/Abstract Full Text View citing articles Show Details

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Effect (Pharmacological Data)

antagonist

Species or TestSystem (Pharmacological Data)

Sprague-Dawley rat

Sex

male

Route of Application

intracutaneous

Concentration (Pharmacological Data)

0.1 mg

Method (Pharmacological Data)

302 animals (253-352 g); 12/12 h light/dark cycle, food and water ad libitum; the animals started receive sodium nitro-prusside (0.01-0.1 mg, i.c.) 1 h after treatment with title comp.; blood pressure

Results

title comp. attenuated the sodium nitro-prusside-induced decrease in mean arterial pressure

Reference

Chang; Pan; Lin

British Journal of Pharmacology, 2001 , vol. 132, # 7 p. 1524 - 1530 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

antagonist

Species or TestSystem (Pharmacological Data)

Sprague-Dawley rat

Sex

male

Route of Application

intracutaneous

Concentration (Pharmacological Data)

0.1 mg

Method (Pharmacological Data)

302 animals (253-352 g); 12/12 h light/dark cycle, food and water ad libitum; the animals started receive 8-Br-cyclic GMP (0.05 mg, i.c.) 1 h after treatment with title comp.; blood pressure

Results

title comp. attenuated the 8-Br-cGMP-induced decrease in mean arterial pressure

Reference

Chang; Pan; Lin

British Journal of Pharmacology, 2001 , vol. 132, # 7 p. 1524 - 1530 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

antagonist

Species or TestSystem (Pharmacological Data)

Sprague-Dawley rat

Sex

male

Route of Application

intracutaneous

Concentration (Pharmacological Data)

0.1 mg

Method (Pharmacological Data)

302 animals (253-352 g); 12/12 h light/dark cycle, food and water ad libitum; the animals started receive hydroxylamine (0.01-0.1 mg, i.c.) 1 h after treatment with title comp.; blood pressure

Results

title comp. attenuated the hydroxylamine-induced decrease in mean arterial pressure

Reference

Chang; Pan; Lin

British Journal of Pharmacology, 2001 , vol. 132, # 7 p. 1524 - 1530 Title/Abstract Full Text View citing articles Show Details

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Effect (Pharmacological Data)

behavioural symptoms

Species or TestSystem (Pharmacological Data)

Swiss albino mouse

Sex

male

Route of Application

intracerebroventricular

Concentration (Pharmacological Data)

2 μg

Kind of Dosing (Pharmacological Data)

given into cerebral ventricle, in volume of 5 μl; dissolved in isotonic saline (0.9percent NaCl)

Method (Pharmacological Data)

motor coordination evaluated by rota-rod test (16 r.p.m.) starting 15 min after title comp. treatment; number of falls from rod in 30 s recorded for up to 60 min post-treatment

Further Details (Pharmacological Data)

control: saline

Results

number of falls increased from 2.4 (before treatment) to 3.1, 3.3 and 2.7 at 15, 30 and 45 min after treatment, resp.

Reference

Pirisino; Ghelardini; Banchelli; Galeotti; Raimondi

British Journal of Pharmacology, 2001 , vol. 134, # 4 p. 880 - 886 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

anorectic

Species or TestSystem (Pharmacological Data)

Swiss albino mouse

Sex

male

Route of Application

intracerebroventricular

Concentration (Pharmacological Data)

Ca. 2 μg

Kind of Dosing (Pharmacological Data)

given into cerebral ventricle, in volume of 5 μl; dissolved in isotonic saline (0.9percent NaCl); used as sulphate

Method (Pharmacological Data)

mice starved for 12 h, food consumption measured up to 60 min after title comp. treatment

Further Details (Pharmacological Data)

control: saline

Results

title comp. reduced food consumption from 677 to 247 mg/mouse

Reference

Pirisino; Ghelardini; Banchelli; Galeotti; Raimondi

British Journal of Pharmacology, 2001 , vol. 134, # 4 p. 880 - 886 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor; binding activity

Species or TestSystem (Pharmacological Data)

NIH-3T3 cell membranes expressing rat 5-HT2A receptors

Kind of Dosing (Pharmacological Data)

as sulfate

Method (Pharmacological Data)

in vitro; radioligand competition binding assay; 0.5 nmol/l <3H>ketanserin used as radioligand; binding buffer, pH 7.4; 37 deg C; incubated for 30 min; liquid scintillation counting; nonspecific binding determined using 10 μmol/l ketanserin


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Type (Pharmacological Data)

Ki

Value of Type (Pharmacological Data)

> 10000 nmol/l

Reference

Dowd; Herrick-Davis; Egan; DuPre; Smith; Teitler; Glennon

Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 3074 - 3084 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor; binding activity

Species or TestSystem (Pharmacological Data)

A-9 cell membranes expressing rat 5-HT2C receptors

Kind of Dosing (Pharmacological Data)

as sulfate

Method (Pharmacological Data)

in vitro; radioligand competition binding assay; 2.0 nmol/l <3H>mesulegrine used as radioligand; binding buffer, pH 7.4; 37 deg C; incubated for 30 min; liquid scintillation counting; nonspecific binding determined using 1 μmol/l mesulegrine

Type (Pharmacological Data)

Ki

Value of Type (Pharmacological Data)

> 10000 nmol/l

Reference

Dowd; Herrick-Davis; Egan; DuPre; Smith; Teitler; Glennon

Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 3074 - 3084 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

neuroregulatoric

Species or TestSystem (Pharmacological Data)

Wistar rat

Sex

male

Route of Application

intracerebral

Concentration (Pharmacological Data)

1 - 1000 μmol/l

Kind of Dosing (Pharmacological Data)

dissolved in ACF

Method (Pharmacological Data)

title comp. perfused via microdialysis probe (reversed microdialysis) into different subregions of prefrontal cortex for 60 min; norepinephrine, serotonin, choline, acetylcholine conc. in dialysate determined by chromatography before and after perfusion

Further Details (Pharmacological Data)

anaesthetized rats; medial prefrontal subregions: dorsal prelimbic/anterior cingulate cortex and ventral prelimbic/infralimbic cortex; ACF: artificial cerebrospinal fluid

Results

title comp. produced dose-dependent increase in choline, norepinephrine, serotonin levels in both anterior cingulate and infralimbic cortices; acetylcholine level was increased in dose-dependent manner in infralimbic but not in anterior cingulate cortex

Reference

Hedou, Gael; Homberg, Judith; Martin, Sonsoles; Wirth, Katja; Feldon, Joram; Heidbreder, Christian A.

European Journal of Pharmacology, 2000 , vol. 390, # 1-2 p. 127 - 136 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

behavioural symptoms

Species or TestSystem (Pharmacological Data)

Swiss A mice


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Sex

female

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

5 mg/kg

Exposure Period (Pharmacological Data)

30 min

Method (Pharmacological Data)

in vivo; 10 mice, 18-22 g; head-dip test; 30 min after treatment with title comp. mice were placed singly on a wooden board with 16 evenly spaced holes; No. of times the head was dipped into the holes during 3 min was counted

Further Details (Pharmacological Data)

control: physiological saline

Comment (Pharmacological Data)

No effect

Reference

Pal, Siddhartha; Sen; Chaudhuri, A.K. Nag

Journal of Pharmacy and Pharmacology, 1999 , vol. 51, # 3 p. 313 - 318 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

biotransformation

Endpoint of Effect (Pharmacological Data)

metabolite formation, Vmax

Species or TestSystem (Pharmacological Data)

human CYP2D6 microsomal product

Concentration (Pharmacological Data)

30.18 nmol/l

Kind of Dosing (Pharmacological Data)

CYP2D6: 0.5 mg/incubation

Method (Pharmacological Data)

CYP2D6 isozyme isolated from a transfected human AHH-1 TK+/- cell line; incubation with title comp. at 37 deg C, pH 7.4 for 2 h with NADPH-generating system; metabolites were quantified after acetylation by GC

Results

single 4-hydroxylated metabolite; rate of metabolite formation: 0.16 nmol/h/mg protein

Metabolite (Pharmacological Data)

HO-NBA [Reaxys RN: 3264229]

Reference

Bach, Mimi V.; Coutts; Baker

Xenobiotica, 1999 , vol. 29, # 7 p. 719 - 732 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

effect on neurochemical response

Species or TestSystem (Pharmacological Data)

Sprague-Dawley rat

Sex

male

Concentration (Pharmacological Data)

2.5 - 4 mg/kg

Method (Pharmacological Data)

microdialysis rats (325-350 g) received title comp.

Further Details (Pharmacological Data)

extracellular serotonin (5-HT) response in caudate-putamen (CP) and nucleus accumbens (NA)

Results

title comp. promoted pronounced changes in extracellular levels of 5-HT in CP or NA; graphical representation


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Reference

Segal, David S.; Kuczenski, Ronald

Journal of Pharmacology and Experimental Therapeutics, 1999 , vol. 291, # 1 p. 19 - 30 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

transport; inhibition of

Species or TestSystem (Pharmacological Data)

HEK cells expressing human dopamine transporter

Method (Pharmacological Data)

cells were pre-incubated with title comp. for 10 min before addition of <3H>DA; then incubated for 10 min; filtered; radioactivity remaining on the filter was measured by liquid scintillation counting

Further Details (Pharmacological Data)

DA: dopamine; <3H>DA was used as radiolabel; non-specific uptake was defined in presence of mazindol; Krebs-HEPES buffer; 25 deg C, water bath

Type (Pharmacological Data)

IC50

Value of Type (Pharmacological Data)

29.3 nmol/l

Reference

Cashman, John R.; Xiong, Yeng N.; Lifen, Xu; Janowsky, Aaron

Journal of Pharmacology and Experimental Therapeutics, 1999 , vol. 288, # 3 p. 1251 - 1260 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

transport; inhibition of

Species or TestSystem (Pharmacological Data)

HEK cells expressing human norepinephrine transporter

Method (Pharmacological Data)

cells were pre-incubated with title comp. for 10 min before addition of <3H>NE; then incubated for 10 min; filtered; radioactivity remaining on the filter was measured by liquid scintillation counting

Further Details (Pharmacological Data)

NE: norepinephrine; <3H>NE was used as radiolabel; non-specific uptake was defined in presence of mazindol; Krebs-HEPES buffer; 25 deg C, water bath

Type (Pharmacological Data)

IC50

Value of Type (Pharmacological Data)

26.3 nmol/l

Reference

Cashman, John R.; Xiong, Yeng N.; Lifen, Xu; Janowsky, Aaron

Journal of Pharmacology and Experimental Therapeutics, 1999 , vol. 288, # 3 p. 1251 - 1260 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

transport; inhibition of

Species or TestSystem (Pharmacological Data)

HEK cells expressing human serotonin transporter

Method (Pharmacological Data)

cells were pre-incubated with title comp. for 10 min before addition of <3H>5-HT; then incubated for 10 min; filtered; radioactivity remaining on the filter was measured by liquid scintillation counting

Further Details (Pharmacological Data)

<3H>5-HT: <3H>5-hydroxytryptamine was used as radiolabel; non-specific uptake was defined in presence of imipramine; Krebs-HEPES buffer; 25 deg C, water bath

Type (Pharmacological Data)

IC50

Value of Type (Pharmacological Data)

1867 nmol/l


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Reference

Cashman, John R.; Xiong, Yeng N.; Lifen, Xu; Janowsky, Aaron

Journal of Pharmacology and Experimental Therapeutics, 1999 , vol. 288, # 3 p. 1251 - 1260 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

transport; inhibition of

Species or TestSystem (Pharmacological Data)

C6 glioma cells expressing human dopamine transporter

Method (Pharmacological Data)

cells were pre-incubated with <3H>MPP(1+) for 20 min; room temp.; washed; pre-incubated with release buffer for 10 min before title comp. was added; 37 deg C; radioactivity remaining in the cells was measured by liquid scintillation spectrometry

Further Details (Pharmacological Data)

<3H>MPP(1+): <3H>1-methyl-4-phenylpyridinium was used as radiolabel; non-specific uptake was defined in presence of mazindol; Krebs-HEPES buffer, pH 7.4; release was stimulated with trichloroacetic acid

Type (Pharmacological Data)

IC50

Value of Type (Pharmacological Data)

153 nmol/l

Reference

Cashman, John R.; Xiong, Yeng N.; Lifen, Xu; Janowsky, Aaron

Journal of Pharmacology and Experimental Therapeutics, 1999 , vol. 288, # 3 p. 1251 - 1260 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

transport; inhibition of

Species or TestSystem (Pharmacological Data)

C6 glioma cells expressing human serotonin transporter

Method (Pharmacological Data)

cells were pre-incubated with <3H>MPP(1+) for 20 min; room temp.; washed; pre-incubated with release buffer for 10 min before title comp. was added; 37 deg C; radioactivity remaining in the cells was measured by liquid scintillation spectrometry

Further Details (Pharmacological Data)

<3H>MPP(1+): <3H>1-methyl-4-phenylpyridinium was used as radiolabel; non-specific uptake was defined in presence of mazindol; Krebs-HEPES buffer, pH 7.4; release was stimulated with trichloroacetic acid

Type (Pharmacological Data)

IC50

Value of Type (Pharmacological Data)

224.2 nmol/l

Reference

Cashman, John R.; Xiong, Yeng N.; Lifen, Xu; Janowsky, Aaron

Journal of Pharmacology and Experimental Therapeutics, 1999 , vol. 288, # 3 p. 1251 - 1260 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor blocking agent

Species or TestSystem (Pharmacological Data)

HEK cell membranes expressing human dopamine transporter

Method (Pharmacological Data)

radioligand binding assay; membranes were isolated; preincubated with title comp. for 10 min before addition of <125I>RTI-55; incubated for 90 min; filtered; radioactivity remaining on the filter was measured by liquid scintillation counting

Further Details (Pharmacological Data)

non-specific binding was defined in presence of mazindol; Krebs-HEPES buffer, room temp., darkness

Type (Pharmacological Data)

Ki

Value of Type (Pharmacological Data)

572000 nmol/l


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Reference

Cashman, John R.; Xiong, Yeng N.; Lifen, Xu; Janowsky, Aaron

Journal of Pharmacology and Experimental Therapeutics, 1999 , vol. 288, # 3 p. 1251 - 1260 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor blocking agent

Species or TestSystem (Pharmacological Data)

HEK cell membranes expressing human serotonin transporter

Method (Pharmacological Data)

radioligand binding assay; membranes were isolated; preincubated with title comp. for 10 min before addition of <125I>RTI-55; incubated for 90 min; filtered; radioactivity remaining on the filter was measured by liquid scintillation counting

Further Details (Pharmacological Data)

non-specific binding was defined in presence of imipramine; Krebs-HEPES buffer, room temp., darkness

Type (Pharmacological Data)

Ki

Value of Type (Pharmacological Data)

37700 nmol/l

Reference

Cashman, John R.; Xiong, Yeng N.; Lifen, Xu; Janowsky, Aaron

Journal of Pharmacology and Experimental Therapeutics, 1999 , vol. 288, # 3 p. 1251 - 1260 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor blocking agent

Species or TestSystem (Pharmacological Data)

HEK cell membranes expressing human NET

Method (Pharmacological Data)

radioligand binding assay; membranes were isolated; preincubated with title comp. for 10 min before addition of <125I>RTI-55; incubated for 90 min; filtered; radioactivity remaining on the filter was measured by liquid scintillation counting

Further Details (Pharmacological Data)

non-specific binding was defined in presence of mazindol; Krebs-HEPES buffer, room temp., darkness; NET: norepinephrine transporter

Type (Pharmacological Data)

Ki

Value of Type (Pharmacological Data)

926 nmol/l

Reference

Cashman, John R.; Xiong, Yeng N.; Lifen, Xu; Janowsky, Aaron

Journal of Pharmacology and Experimental Therapeutics, 1999 , vol. 288, # 3 p. 1251 - 1260 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or TestSystem (Pharmacological Data)

Homo sapiens

Concentration (Pharmacological Data)

1.25 - 10 mg

Method (Pharmacological Data)

pharmacokinetics of two dosage bioavailability of drug determining; a 1.25 mg Zydis dosage form and a 10 mg Movergan tablets

Results

mean AUC: 56.4 nM/h for Zydis dosage form; 698.7 nM/h for Movergan tablets

Reference

Seager

Journal of Pharmacy and Pharmacology, 1998 , vol. 50, # 4 p. 375 - 382 Title/Abstract Full Text View citing articles Show Details

Effect

toxicity, acute


(Pharmacological Data)

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Species or TestSystem (Pharmacological Data)

mice

Route of Application

intraperitoneal

Type (Pharmacological Data)

LD50

Value of Type (Pharmacological Data)

300 mg/kg

Reference

Morozov; Klimova; Lavrova; Avdyunina; Pyatin; Troitskaya; Bykov

Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 1 p. 1 - 4 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

anticatalepsic

Species or TestSystem (Pharmacological Data)

white mongrel rat

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

5 mg/kg

Kind of Dosing (Pharmacological Data)

in form of aqueous solutions or finely dispersed suspensions with Tween-80 (0.04 percent)

Method (Pharmacological Data)

5 animals; 180-200 g body weight; triftazin-induced catalepsy; triftazin (at a dose of 2 mg/kg) was introduced 30 min before observation; control

Further Details (Pharmacological Data)

reference compound; at the dose producing maximum specific effect; administered 1 h before observation

Reference

Morozov; Klimova; Lavrova; Avdyunina; Pyatin; Troitskaya; Bykov

Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 1 p. 1 - 4 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

psychostimulant

Endpoint of Effect (Pharmacological Data)

spontaneous motor activity

Species or TestSystem (Pharmacological Data)

white mongrel mice

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

5 mg/kg

Kind of Dosing (Pharmacological Data)

in form of aqueous solutions or finely dispersed suspensions with Tween-80 (0.04 percent)

Method (Pharmacological Data)

15-20 animals; 18-22 g body weight; placed into individual compartments; number of horizontal movements during a 15 min time interval; control

Further Details

reference compound; at the dose producing maximum specific effect; administered 1 h before experiment


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Results

significant effect

Reference

Morozov; Klimova; Lavrova; Avdyunina; Pyatin; Troitskaya; Bykov

Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 1 p. 1 - 4 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

psychostimulant

Endpoint of Effect (Pharmacological Data)

working capacity

Species or TestSystem (Pharmacological Data)

white mongrel mice

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

5 mg/kg

Kind of Dosing (Pharmacological Data)

in form of aqueous solutions or finely dispersed suspensions with Tween-80 (0.04 percent)

Method (Pharmacological Data)

20-30 animals; 18-22 g body weight; loaded with 10 percent of the body weight; duration of swimming to complete fatigue in water at 27 deg C; control

Further Details (Pharmacological Data)

reference compound; at the dose producing maximum specific effect; administered 1 h before experiment

Results

pronounced stimulating effect

Reference

Morozov; Klimova; Lavrova; Avdyunina; Pyatin; Troitskaya; Bykov

Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 1 p. 1 - 4 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

psychomotor activation

Species or TestSystem (Pharmacological Data)

Sprague Dawley rats

Sex

male

Route of Application

intravenous

Concentration (Pharmacological Data)

0.125 - 8.0 mg/kg/day

Exposure Period (Pharmacological Data)

5 d

Method (Pharmacological Data)

rats (200-225 g) cannulated (dural surface); 5 days habituation, title compd. administering; two groups: home and novel; rotational behavior data collection (5 min intervals, 2 h periods)

Further Details (Pharmacological Data)

home group: animals transported to testing room; novel group: animals housed in main animal colony (excludind 2 h experimental periods)

Results

lower doses are necessary to induce sensitization in novel group; dose- and time-dependent rotational behavior evaluated (diagrams)

Reference

Browman; Badiani; Robinson

Journal of Pharmacology and Experimental Therapeutics, 1998 , vol. 287, # 3 p. 1007 - 1014 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

peristaltic stimulant


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Species or TestSystem (Pharmacological Data)

Sprague-Dawley rat

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

1 mg/kg

Kind of Dosing (Pharmacological Data)

once daily for 10 days

Method (Pharmacological Data)

rats received gastric intubation of Na2<51>CrO4 and 10 percent charcoal; 15 min later rats killed; radioactivity of stomach and each small intestine segment measured by liquid scintillation counting

Results

title comp. inhibited gastric emptying (49.3 versus 66.1 percent in control)

Reference

Doong, Ming-Luen; Lu, Chien-Chen; Kau, Mei-Mei; Tsai, Shiow-Chwen; Chiao, Yu-Chung; Chen, Jiann-Jong; Yeh, Jiun-Yih; Lin, Ho; Huang, Seng-Wong; Chen, Tseng-Shing; Chang, Full-Young; Wang, Paulus S.

British Journal of Pharmacology, 1998 , vol. 124, # 6 p. 1123 - 1130 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

releasing hormones

Species or TestSystem (Pharmacological Data)

Sprague-Dawley rat

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

0.75 - 3 mg/kg

Method (Pharmacological Data)

45 min after title comp. treatment blood samples collected; CCK concentration measured by RIA

Further Details (Pharmacological Data)

CCK: cholecystokinin

Results

3.0 mg/kg title comp. significantly increased plasma CCK level from 46.8 to 57.6 pg/ml

Reference

Doong, Ming-Luen; Lu, Chien-Chen; Kau, Mei-Mei; Tsai, Shiow-Chwen; Chiao, Yu-Chung; Chen, Jiann-Jong; Yeh, Jiun-Yih; Lin, Ho; Huang, Seng-Wong; Chen, Tseng-Shing; Chang, Full-Young; Wang, Paulus S.

British Journal of Pharmacology, 1998 , vol. 124, # 6 p. 1123 - 1130 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

peristaltic stimulant

Species or TestSystem (Pharmacological Data)

Sprague-Dawley rat

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

0.75 - 3 mg/kg

Method (Pharmacological Data)

title comp. given 30 min before gastric intubation of Na2<51>CrO4 and 10 percent charcoal; 15 min later rats killed; radioactivity of stomach and each small intestine segment measured by liquid scintillation counting

Results

title comp. dose-dependently inhibited gastric emptying (31.3, 26.4 and 20.2 percent at 0.75, 1.5 and 3.0 mg/kg, respectively (control: 67.2 percent)) and intestinal transit (3.0 mg/kg significantly reduced geometric center)

Reference

Doong, Ming-Luen; Lu, Chien-Chen; Kau, Mei-Mei; Tsai, Shiow-Chwen; Chiao, Yu-Chung; Chen, Jiann-Jong; Yeh, Jiun-Yih;


Lin, Ho; Huang, Seng-Wong; Chen, Tseng-Shing; Chang, Full-Young; Wang, Paulus S.

British Journal of Pharmacology, 1998 , vol. 124, # 6 p. 1123 - 1130 Title/Abstract Full Text View citing articles Show Details

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Comment (Pharmacological Data)

miscellaneous activity (test, effect, animals, dose, in vivo): kaluresis, 140percent variation of Na(1+) or K(1+) excretion expressed as meq/100 g body weight, rats, 20 mg/kg, p.o.

Reference

Sparatore; Novelli

Farmaco, 1997 , vol. 52, # 8-9 p. 509 - 521 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

effect on EEG in rats (Mahalanobis' distances)

Reference

Mazurov, Anatoly A.; Andronati, Sergei A.; Korotenko, Tamara I.; Sokolenko, Nikolai I.; Dyadenko, Alexei I.; Shapiro, Yury E.; Gorbatyuk, Vitalii Ya.; Voronina, Tatyana A.

Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 11 p. 2029 - 2040 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

drug dependence

Species or TestSystem (Pharmacological Data)

humans

Sex

male and female

Method (Pharmacological Data)

simple experimental epidemiologic survey of prescription forgeries in community pharmacies (1253 pharmacies) in the Midi-Pyrenees area (southwest France)

Results

12.7 percent of the all forged prescription was made to obtain title compound with phenobarbitone

Reference

Lapeyre-Mestre; Damase-Michel; Adams; Michaud; Montastruc

European Journal of Clinical Pharmacology, 1997 , vol. 52, # 1 p. 37 - 39 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

enzyme; inhib. of

Species or TestSystem (Pharmacological Data)

IIBCE rat brain mitochondrial monoamine oxidase B

Sex

male

Concentration (Pharmacological Data)

0.01 - 100 μmol/l

Kind of Dosing (Pharmacological Data)

in distilled water

Method (Pharmacological Data)

MAO-B activity determined by HPLC with electrochemical detection after incubation with selective substrate of DMAPEA in presence of title comp. at 37 deg C for 5 min, pH 7.4; DMAPEA and its MAO-B metabolite DMAPAA used to calculate MAO-B activity

Further Details (Pharmacological Data)

MAO-B = monoamine oxidase B; DMAPEA = 4-dimethylaminophenethylamine, 5 μmol/l; DMAPAA = 4-dimethylaminophenylacetic acid

Comment (Pharmacological Data)

No effect

Reference

Scorza, Ma. Cecilia; Carrau, Cecilia; Silveira, Rodolfo; Zapata-Torres, Gerald; Cassels, Bruce K.; Reyes-Parada, Miguel

Biochemical Pharmacology, 1997 , vol. 54, # 12 p. 1361 - 1369 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

enzyme; inhib. of

Species or TestSystem (Pharmacological Data)

IIBCE rat brain mitochondrial monoamine oxidase A


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Sex

male

Concentration (Pharmacological Data)

0.01 - 100 μmol/l

Kind of Dosing (Pharmacological Data)

in distilled water

Method (Pharmacological Data)

MAO-A activity determined by HPLC with electrochemical detection after incubation with selective substrate of 5-HT in presence of title comp. at 37 deg C for 10 min, pH 7.4; 5-HT and its MAO-A metabolite 5-HIAA used to calculate MAO-A activity

Further Details (Pharmacological Data)

MAO-A = monoamine oxidase A; 5-HT = serotonin, 2.5 μmol/l; 5-HIAA = 5-hydroxyindoleacetic acid

Type (Pharmacological Data)

IC50

Value of Type (Pharmacological Data)

11 μmol/l

Reference

Scorza, Ma. Cecilia; Carrau, Cecilia; Silveira, Rodolfo; Zapata-Torres, Gerald; Cassels, Bruce K.; Reyes-Parada, Miguel

Biochemical Pharmacology, 1997 , vol. 54, # 12 p. 1361 - 1369 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

behavioural symptoms

Species or TestSystem (Pharmacological Data)

Sprague-Dawley rat

Sex

male

Route of Application

subcutaneous

Concentration (Pharmacological Data)

2.5 - 4 mg/kg

Method (Pharmacological Data)

15 SDI in 3 cycles (5 d title comp., 2 d saline), d 20: single dose challenge, d 21: saline, from d 22: 3 run cycles (dose every 2 h, 4 inj. per d for 5 d, then 2 d saline); 2 d after 3 cycle single dose challenge; behaviour monitored by computer, tapin

Reference

Segal, David S.; Kuczenski, Ronald

Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 282, # 2 p. 561 - 573 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

transmitter release; inhibition of

Species or TestSystem (Pharmacological Data)

Sprague-Dawley rat

Sex

male

Route of Application

subcutaneous

Concentration (Pharmacological Data)

4 mg/kg

Kind of Dosing (Pharmacological Data)

title comp. used as sulfate, dissolved in saline, administered at 2 ml/kg

Method (Pharmacological Data)

6 SDI, 48 h after the last injection followed by a run cycle (dose every 2 h, 4 inj. per d for 5 d, then 2 d saline); dialysis probes inserted into caudate-putamen and nucleus accumbens; dialysate samples collected every 30 min, analyzed by HPLC

Further Details (Pharmacological Data)

SDI: single dose injection; saline control; dialysate samples assayed for DA (dopamine), 3,4-dihydroxyphenylacetic acid, homovanillic acid, 3-methoxytyramine, 5-hydroxyindoleacetic acid, 5-HT

Results

title comp. produced a decline in caudate but not nucleus accumbens microdialysate dopamine response; serotonin response decline was insignificant (diagrams)


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Reference

Segal, David S.; Kuczenski, Ronald

Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 282, # 2 p. 561 - 573 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or TestSystem (Pharmacological Data)

rat

Route of Application

subcutaneous

Concentration (Pharmacological Data)

8 mg/kg

Kind of Dosing (Pharmacological Data)

title comp. dissolved in saline, injected in a volume of 1ml/kg

Method (Pharmacological Data)

dialysis probes inserted in caudate-putamen; title comp. given on the next day; dialysate samples collected every 10 or 20 min, assayed for title comp. level by HPLC

Further Details (Pharmacological Data)

kel, kapp: rate constant of elimination and appearance, respectively

Half-life Time (Pharmacological Data)

Ca. 45 min

Results

Tmax = 30.5 min; kel = 0.015 min-1; kapp = 0.042 min-1

Reference

Kuczenski, Ronald; Melega, William P.; Cho, Arthur K.; Segal, David S.

Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 282, # 2 p. 591 - 596 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

transmitter releasing

Species or TestSystem (Pharmacological Data)

rat

Route of Application

subcutaneous

Concentration (Pharmacological Data)

8 mg/kg

Kind of Dosing (Pharmacological Data)

title comp. dissolved in saline, injected in a volume of 1ml/kg

Method (Pharmacological Data)

dialysis probes inserted in caudate-putamen; title comp. given on the next day; dialysate samples collected every 10 or 20 min, assayed for DA, DOPAC, homovanillic acid, 3MT, 5-hydroxyindoleacetic acid by HPLC

Further Details (Pharmacological Data)

DA: dopamine, DOPAC: 3,4-dihydroxyphenylacetic acid, 3MT: 3-methoxytyramine

Results

after title comp. administration, dialysate DA level achieved max. at about 30 min, then gradually declined (diagram, table)

Reference

Kuczenski, Ronald; Melega, William P.; Cho, Arthur K.; Segal, David S.

Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 282, # 2 p. 591 - 596 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or TestSystem (Pharmacological Data)

rat

Route of Application

subcutaneous


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Concentration (Pharmacological Data)

8 mg/kg

Kind of Dosing (Pharmacological Data)

title comp. dissolved in saline, injected in a volume of 1ml/kg

Method (Pharmacological Data)

title comp. given, and caudate-putamen samples collected 5, 10, 20, 30, 60, 120, 240 min later; caudate-putamen homogenate extract assayed for title comp. level by gas chromatography/mass spectrometry

Further Details (Pharmacological Data)

kel, kapp: rate constant of elimination and appearance, respectively

Results

Tmax = 22.4 min; kel = 0.015 min-1; kapp = 0.101 min-1

Reference

Kuczenski, Ronald; Melega, William P.; Cho, Arthur K.; Segal, David S.

Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 282, # 2 p. 591 - 596 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

behavioural symptoms

Species or TestSystem (Pharmacological Data)

rat

Route of Application

subcutaneous

Concentration (Pharmacological Data)

8 mg/kg

Kind of Dosing (Pharmacological Data)

title comp. dissolved in saline, injected in a volume of 1ml/kg

Method (Pharmacological Data)

dialysis probes inserted in caudate-putamen; title comp. given on the next day; behaviour monitored by videotaping up to 3 h

Results

title comp. evoked multiphasic locomotor response that included prolonged period of intense focused stereotypies: licking, biting; max. effect at 60 min, duration up to 3 h (diagram)

Reference

Kuczenski, Ronald; Melega, William P.; Cho, Arthur K.; Segal, David S.

Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 282, # 2 p. 591 - 596 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

incorporation into hair

Species or TestSystem (Pharmacological Data)

Dark-Agouti rats

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

5 mg/kg

Exposure Period (Pharmacological Data)

10 d

Method (Pharmacological Data)

rats of 95-105 g, 5 wks old; back hair of rats shaved; hair collected; blood collected 5, 15, 30, 60, 120, 360 min after dosing; plasma prepared; areas under conc. vs. time curve (AUCs) calculated; incorporated rates (ICRs) determination

Results

AUC, 181.6 μg*min/ml; 18.05 ng/mg conc. in hair; ICR, 0.10

Reference

Nakahara, Yuji; Kikura, Ruri

Archives of Toxicology, 1996 , vol. 70, # 12 p. 841 - 849 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological

drug interaction


Data)

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Species or TestSystem (Pharmacological Data)

testes of Sprague-Dawley rats

Concentration (Pharmacological Data)

1E-11 - 1E-06 mol/l

Method (Pharmacological Data)

in vitro; pieces of rat testes preincubated in Locke solution (90 min); administration of title comp. for 1 h; radioimmunoassay of testosterone after incubation with 3-isobutyl-1-methylxanthine for 1 h

Further Details (Pharmacological Data)

in combination with humanchorionic gonadotropin (0.5 iu/ml)

Type (Pharmacological Data)

testosterone content

Value of Type (Pharmacological Data)

97.32 - 136.48 pg mg-1 h-1

Results

decrease of AMP content relatively to human chorionic gonadotropin alone

Reference

Tsai, Shiow-Chwen; Chiao, Yu-Chung; Lu, Chien-Chen; Doong, Ming-Luen; Chen, Yen-Hao; Shih, Hsi-Chang; Liaw, Charlie; Wang, Shyi-Wu; Wang, Paulus S.

British Journal of Pharmacology, 1996 , vol. 118, # 4 p. 984 - 988 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

drug interaction

Species or TestSystem (Pharmacological Data)

testes of Sprague-Dawley rats

Concentration (Pharmacological Data)

1E-08 - 1E-06 mol/l

Method (Pharmacological Data)

in vitro; pieces of rat testes preincubated in Locke solution (90 min); administration of title comp. for 1 h; radioimmunoassay of cyclic AMP after incubation with 3-isobutyl-1-methylxanthine for 1 h

Further Details (Pharmacological Data)

in combination with human chorionic gonadotropin (5 iu/ml)

Type (Pharmacological Data)

cyclic AMP content

Value of Type (Pharmacological Data)

46.64 - 50.42 fmol/mg protein/h

Results

increase of AMP content relatively to value for human chorionic gonadotropin alone

Reference

Tsai, Shiow-Chwen; Chiao, Yu-Chung; Lu, Chien-Chen; Doong, Ming-Luen; Chen, Yen-Hao; Shih, Hsi-Chang; Liaw, Charlie; Wang, Shyi-Wu; Wang, Paulus S.

British Journal of Pharmacology, 1996 , vol. 118, # 4 p. 984 - 988 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

releasing hormones

Species or TestSystem (Pharmacological Data)

testes of Sprague-Dawley rats

Concentration (Pharmacological Data)

1E-09 - 1E-06 mol/l

Method (Pharmacological Data)

in vitro; pieces of rat testes preincubated in Locke solution (90 min); administration of title comp. for 1 h; radioimmunoassay of testosterone after incubation with 3-isobutyl-1-methylxanthine for 1 h

Type

testosterone content


(Pharmacological Data)

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Value of Type (Pharmacological Data)

14710 - 22690 ng/kg

Results

increase of AMP content relatively to basal value of 38.31 pg/(mg*h)

Reference

Tsai, Shiow-Chwen; Chiao, Yu-Chung; Lu, Chien-Chen; Doong, Ming-Luen; Chen, Yen-Hao; Shih, Hsi-Chang; Liaw, Charlie; Wang, Shyi-Wu; Wang, Paulus S.

British Journal of Pharmacology, 1996 , vol. 118, # 4 p. 984 - 988 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

accumulation of cyclic AMP

Species or TestSystem (Pharmacological Data)

testes of Sprague-Dawley rats

Concentration (Pharmacological Data)

1E-09 - 1E-06 mol/l

Method (Pharmacological Data)

in vitro; pieces of rat testes preincubated in Locke solution (90 min); administration of title comp. for 1 h; radioimmunoassay of cyclic AMP after incubation with 3-isobutyl-1-methylxanthine for 1 h

Type (Pharmacological Data)

cyclic AMP content

Value of Type (Pharmacological Data)

13.38 - 16.47 fmol/(mg*h*protein)

Results

increase of AMP content relatively to basal value

Reference

Tsai, Shiow-Chwen; Chiao, Yu-Chung; Lu, Chien-Chen; Doong, Ming-Luen; Chen, Yen-Hao; Shih, Hsi-Chang; Liaw, Charlie; Wang, Shyi-Wu; Wang, Paulus S.

British Journal of Pharmacology, 1996 , vol. 118, # 4 p. 984 - 988 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

releasing hormones

Species or TestSystem (Pharmacological Data)

Sprague-Dawley rats

Sex

male

Route of Application

intravenous

Concentration (Pharmacological Data)

0.4 μg ml-1 kg-1

Method (Pharmacological Data)

rat weight 300-350 g, catheterized via right jugular vein; administration of title comp. after 20 h; sampling blood at 0, 15, 30, 60, 120, 180, 360, 480 and 1440 min; radioimmunoassay of testosterone and luteinizing hormone

Type (Pharmacological Data)

testosterone in blood plasma

Value of Type (Pharmacological Data)

0.05 - 0.22 μg/l

Results

time-dependent decrease of testosterone level (minimal after 180 min, then increase to basal value); no significant effect on basal level of luteinizing hormone

Reference

Tsai, Shiow-Chwen; Chiao, Yu-Chung; Lu, Chien-Chen; Doong, Ming-Luen; Chen, Yen-Hao; Shih, Hsi-Chang; Liaw, Charlie; Wang, Shyi-Wu; Wang, Paulus S.

British Journal of Pharmacology, 1996 , vol. 118, # 4 p. 984 - 988 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

drug interaction


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Species or TestSystem (Pharmacological Data)

Sprague-Dawley rats

Sex

male

Route of Application

intravenous

Concentration (Pharmacological Data)

0.4 μg ml-1 kg-1

Method (Pharmacological Data)

rat weight 300-350 g, catheterized via right jugular vein; administration of title comp. after 20 h; sampling blood at 0, 15, 30, 60, 120, 180, 360, 480 and 1440 min; radioimmunoassay of testosterone and luteinizing hormone

Further Details (Pharmacological Data)

in combination with human chorionic gonadotropin (5 iu/(ml*kg))

Type (Pharmacological Data)

testosterone in blood plasma

Value of Type (Pharmacological Data)

0.26 μg/l

Results

time-dependent decrease of testosterone level compared to human chorionic gonadotropin alone

Reference

Tsai, Shiow-Chwen; Chiao, Yu-Chung; Lu, Chien-Chen; Doong, Ming-Luen; Chen, Yen-Hao; Shih, Hsi-Chang; Liaw, Charlie; Wang, Shyi-Wu; Wang, Paulus S.

British Journal of Pharmacology, 1996 , vol. 118, # 4 p. 984 - 988 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

behavioural symptoms

Species or TestSystem (Pharmacological Data)

Wistar rat

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

3 mg/kg

Kind of Dosing (Pharmacological Data)

single dose

Method (Pharmacological Data)

8 rats 250-300 g; cage with white, central grey, and black chamber; day 1: chamber preference monitoring, 15 min; day 2: after title comp. administration the animal was placed in black or white chamber for 20 min; day 3: chamber preference monitoring

Further Details (Pharmacological Data)

day 1: animals introduced to grey chamber; day 3: animals introduced to grey chamber; preference is expressed as time spent in this chamber; controls were administered saline

Results

rats showed twofold higher preference for title comp.-paired chamber in comparison with controls

Reference

Zurita, Alejandra; Muru, Sergio; Molina, Victor

European Journal of Pharmacology, 1996 , vol. 299, # 1-3 p. 1 - 7 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

behavioural symptoms

Species or TestSystem (Pharmacological Data)

Wistar rat

Sex

male

Route of Application

intraperitoneal

Concentration

1.56 mg/kg


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Kind of Dosing (Pharmacological Data)

single dose just before testing

Method (Pharmacological Data)

animal weight 400-590 g; 6-hydroxydopamine (16 μg/4 μl) injected into left nigra; one week recovery; animal with electro-mechanical transducer placed in Perspex bowl (diam. 40 cm); count registered when animal turned through 36 degrees both directions

Further Details (Pharmacological Data)

stereotaxic coordinates for 6-hydroxydopamine injection: AP 1.9, L 1.8, AP -2.1; counts accumulated 120 min

Results

title comp. induced more than 60 ipsiversive rotations of animals in 60 min

Reference

Eblen, Frank; Loeschmann, Peter-Andreas; Wuellner, Ullrich; Turski, Lechoslaw; Klockgether, Thomas

European Journal of Pharmacology, 1996 , vol. 299, # 1-3 p. 9 - 16 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

dopaminergic

Species or TestSystem (Pharmacological Data)

Wistar rat

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

1.75 mg/kg

Method (Pharmacological Data)

rat weight 250-275 g; 7 low and 7 high sugar feeders; 7 d adaptation period then 1 ml/kg i.p. saline injection; cannulation 2 mm dorsal to posterior-medial nucleus accumbens; aCSF perfusion; title comp. treatment; samples collected every 20 min; HPLC-EC

Further Details (Pharmacological Data)

dopamine (DA) concentration analysis; DA concentration - time curve in low and high sugar feeders; aCSF = artificial cerebrospinal fluid

Results

title comp. immediately increased DA concentration (peaked at 40 min and slowly diminished over 3 h test session) both low and high sugar feeders (diagrams given); sugar consumption correlated with title comp.-stimulated accumbens-DA overflow

Reference

Sills, Terrence L.; Crawley, Jacqueline N.

European Journal of Pharmacology, 1996 , vol. 303, # 3 p. 177 - 181 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

behavioural symptoms

Species or TestSystem (Pharmacological Data)

Wistar rat

Sex

female

Route of Application

subcutaneous

Concentration (Pharmacological Data)

0.5 mg/kg

Method (Pharmacological Data)

in vivo; rats (181-262 g) trained for immobility; title comp. or saline injected; behaviour investigated

Results

relative to saline title comp. decreased immobility (figure)

Reference

Maes, J. H. Roald; Van Rijn, Clementina M.; Vossen, Jo M. H.

European Journal of Pharmacology, 1996 , vol. 309, # 2 p. 131 - 140 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

agonist

Species or TestSystem

Sprague-Dawley rat


(Pharmacological Data)

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Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

2 mg/kg

Kind of Dosing (Pharmacological Data)

dose in 0.9 percent saline

Method (Pharmacological Data)

rat weight 350-400 g; 4 animals/group; bipolar electrode implantation into lateral hypothalamus; after 8-10 d title comp. injection; 10 training self-stimulation sessions for 13 h (50 to 100 μA)

Further Details (Pharmacological Data)

lever-pressing behaviour analysis; time - response curve

Results

title comp. produced marked facilitation of self-stimulation with peak effect seen 2 h after injection (diagram given)

Reference

Olds, Marianne E.

European Journal of Pharmacology, 1996 , vol. 306, # 1-3 p. 23 - 32 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

drug interaction

Species or TestSystem (Pharmacological Data)

Sprague-Dawley rat

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

2 mg/kg

Kind of Dosing (Pharmacological Data)

dose in 0.9 percent saline

Method (Pharmacological Data)

rat weight 350-400 g; 4 animals/group; bipolar electrode implantation into lateral hypothalamus; after 8-10 d title comp. plus 0.1 mg/kg i.p. MK-801 injection; 10 training self-stimulation sessions for 13 h (50 to 100 μA)

Further Details (Pharmacological Data)

lever-pressing behaviour analysis; time - response curve

Results

title comp. plus MK-801 resulted greater and longer-lasting facilitation than increase in responding produced by either drug alone (diagram given)

Reference

Olds, Marianne E.

European Journal of Pharmacology, 1996 , vol. 306, # 1-3 p. 23 - 32 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

effect on spontaneous motor activity in albino Swiss mice of either sexes at the dose of 5 mg/kg p.o., 60 and 120 min after administration, variations of spontaneous motility are 19.09percent and 76.88percent, resp.

Reference

Vega; Soledad Gil; Darias; Sanchez Mateo; Exposito

Pharmazie, 1995 , vol. 50, # 1 p. 27 - 33 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

anxiolytic action, albino Swiss mice of either sexes, 5 mg/kg p.o., plus-maze and holeboard test; anticonvulsant activity in the pentetrazole (120 mg/kg i.p.) and strychnine sulphate (2.5 mg/kg i.p.) seizures, albino Swiss mice of either sexes

Reference

Vega; Soledad Gil; Darias; Sanchez Mateo; Exposito

Pharmazie, 1995 , vol. 50, # 1 p. 27 - 33 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

antagonist


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Species or TestSystem (Pharmacological Data)

COS-7 cells

Exposure Period (Pharmacological Data)

1 h

Method (Pharmacological Data)

cells transfected with cDNA of human plasmalemmal dopamine transporter (DAT) cells and vesicular amine transporter (DAT/VAT) cells exposed for to 0.3 μM <3H>dopamine and title compound

Further Details (Pharmacological Data)

liquid scintillation counted

Results

inhibited initial rate of <3H>dopamine uptake (5 min accumulation) with Ki of 0.29 μM (DAT) and 0.7 μM (DAT/VAT)

Reference

Pifl, Christian; Drobny, Helmut; Reither, Harald; Hornykiewicz, Oleh; Singer, Ernst A.

Molecular Pharmacology, 1995 , vol. 47, # 2 p. 368 - 373 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

dopaminergic

Species or TestSystem (Pharmacological Data)

COS-7 cells

Concentration (Pharmacological Data)

0.01 - 100 μmol/l

Exposure Period (Pharmacological Data)

4 min

Method (Pharmacological Data)

cells transfected with cDNA of human plasmalemmal dopamine transporter (DAT) cells; labelling with 0.3 μM <3H>dopamine at 37 deg C, 60 min; title compound added to superfusion medium

Further Details (Pharmacological Data)

liquid scintillation counted

Type (Pharmacological Data)

EC50

Value of Type (Pharmacological Data)

1.1 μmol/l

Results

rapid but transient <3H>dopamine release, maximum at 10 μM of title compound; cocain (1 or 10 μM) decreased this effect (caused a shift to the right of the concentration-response curve)

Reference

Pifl, Christian; Drobny, Helmut; Reither, Harald; Hornykiewicz, Oleh; Singer, Ernst A.

Molecular Pharmacology, 1995 , vol. 47, # 2 p. 368 - 373 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

dopaminergic

Species or TestSystem (Pharmacological Data)

COS-7 cells

Exposure Period (Pharmacological Data)

4 min

Method (Pharmacological Data)

cells transfected with cDNA of human plasmalemmal dopamine and vesicular amine transporter (DAT/VAT) cells, title compound added to superfusion medium containing 0.3 μM <3H>dopamine

Further Details (Pharmacological Data)

liquid scintillation counting

Results

rapid and reversible concentration dependent increase in <3H>dopamine efflux, saturation not observed at concentration up to 100 μM

Reference

Pifl, Christian; Drobny, Helmut; Reither, Harald; Hornykiewicz, Oleh; Singer, Ernst A.

Molecular Pharmacology, 1995 , vol. 47, # 2 p. 368 - 373


Title/Abstract Full Text View citing articles Show Details

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Effect (Pharmacological Data)

dopaminergic

Species or TestSystem (Pharmacological Data)

COS-7 cells

Concentration (Pharmacological Data)

10 μmol/l

Exposure Period (Pharmacological Data)

36 min

Method (Pharmacological Data)

cells were transfected with cDNA of human synaptic vesicle amine transporter (VAT) cells; exposed with 1 μM <3H>dopamine for 1 h; title compound added to buffer from 12 min until the end of experiment

Further Details (Pharmacological Data)

liquid scintillation counted

Results

small stepwise increase in <3H>dopamine release

Reference

Pifl, Christian; Drobny, Helmut; Reither, Harald; Hornykiewicz, Oleh; Singer, Ernst A.

Molecular Pharmacology, 1995 , vol. 47, # 2 p. 368 - 373 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

dopaminergic

Species or TestSystem (Pharmacological Data)

COS-7 cells

Concentration (Pharmacological Data)

1 μmol/l

Exposure Period (Pharmacological Data)

36 min

Method (Pharmacological Data)

cells were transfected with cDNA of human plasmalemmal dopamine- and vesicular amine- transporter (DAT/VAT cells); exposed with 0.3 μM <3H>dopamine for 1 h; title compound was added to buffer from 12 min until the end of experiment

Further Details (Pharmacological Data)

liquid scintillation counted

Results

increase of efflux of <3H>dopamine that remained elevated above base-line values after it had reached its peak

Reference

Pifl, Christian; Drobny, Helmut; Reither, Harald; Hornykiewicz, Oleh; Singer, Ernst A.

Molecular Pharmacology, 1995 , vol. 47, # 2 p. 368 - 373 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

dopaminergic

Species or TestSystem (Pharmacological Data)

COS-7 cells

Concentration (Pharmacological Data)

1 μmol/l

Exposure Period (Pharmacological Data)

36 min

Method (Pharmacological Data)

cells were transfected with cDNA of human plasmalemmal dopamine transporter (DAT cells); exposed with 0.3 μM <3H>dopamine for 1 h; title compound was added to buffer from 12 min until the end of experiment

Further Details (Pharmacological

liquid scintillation counted


Data)

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Results

<3H>dopamine efflux reached a maximum within 8 min, and subsequently returned to base-line in spite of the containing presence of title compound

Reference

Pifl, Christian; Drobny, Helmut; Reither, Harald; Hornykiewicz, Oleh; Singer, Ernst A.

Molecular Pharmacology, 1995 , vol. 47, # 2 p. 368 - 373 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

stimulation of efflux

Species or TestSystem (Pharmacological Data)

LLC-PK1 cells

Exposure Period (Pharmacological Data)

30 min

Method (Pharmacological Data)

cells transfected with cDNA encoding rat serotonin transporter (SERT), human norepinephrine transporter (NET) or rat dopamine transporter (DAT); incubated with radiolabelled 5-HT (SERT) or 1-methyl-4-phenylpyridinium(1+) (MPP) at 37 deg C

Further Details (Pharmacological Data)

washing, 30 min incubation with title comp.; activity measured; at concentration that inhibited transport by 80 percent

Results

title comp. increased MPP by 58 percent (NET), 48 percent (DAT), 5-HT efflux by 7 percent (SERT); 50μM mazindol decreased this effect; diagram given

Reference

Wall, Stephen C.; Gu, Howard; Rudnick, Gary

Molecular Pharmacology, 1995 , vol. 47, # 3 p. 544 - 550 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

transporter, inhibition of

Species or TestSystem (Pharmacological Data)

LLC-PK1 cells

Exposure Period (Pharmacological Data)

4 min

Method (Pharmacological Data)

cells transfected with cDNA encoding SERT, NET or DAT; incubation with radiolabeled 5-HT (SERT) or MPP(1+) (NET and DAT) and title comp. at room temp.; uptake of activity measured

Results

potent inhibitor for all three transporters; diagram given

Reference

Wall, Stephen C.; Gu, Howard; Rudnick, Gary

Molecular Pharmacology, 1995 , vol. 47, # 3 p. 544 - 550 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

Accumulation

Species or TestSystem (Pharmacological Data)

human

Sex

male

Method (Pharmacological Data)

chronic drug abuse; sampling head hair and fingernail; hot alkaline hydrolysis; deuterated internal standard; three-step extraction procedure; derivatization by propionylation; GC/MS analysis

Further Details (Pharmacological Data)

22-year old male

Results

concentration: 10.2 ng/mg in hair and 12.0 ng/mg in fingernail

Reference

Cirimele; Kintz; Mangin

Archives of Toxicology, 1995 , vol. 70, # 1 p. 68 - 69 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological

AUC


Data)

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Species or TestSystem (Pharmacological Data)

dark-agouti rat

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

2.5 mg/kg

Kind of Dosing (Pharmacological Data)

drug administered once a day for 10 successive days

Exposure Period (Pharmacological Data)

10 d

Method (Pharmacological Data)

rats 5 weeks old; back hair shaved before experiment; blood samples collected 5, 15, 30, 60, 120, 360 min after drug administration; newly grown hair samples collected 4 weeks after first drug administration

Further Details (Pharmacological Data)

drug level in plasma and hair determination; GC/MS; HPLC

Type (Pharmacological Data)

AUC

Value of Type (Pharmacological Data)

85.3 μg*min/ml

Results

concentration in hair <H> = 13.2 ng/mg; drug incorporation rate ICR (<H>/AUC) = 0.15

Reference

Nakahara; Takahashi; Kikura

Biological and Pharmaceutical Bulletin, 1995 , vol. 18, # 9 p. 1223 - 1227 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

hyperlocomotion inducer

Species or TestSystem (Pharmacological Data)

Wistar rats

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

0.16 - 2.5 mg/kg

Method (Pharmacological Data)

rats placed into cages, movement recorded for 60 min by infrared beams

Further Details (Pharmacological Data)

effect of dopamine D2 and 5-HT2A receptor antagonists on hyperlocomotion caused by title compound

Results

title compound dose dependently elicited hyperlocomotion; this effect blocked by dopamine D2 receptor antagonists (r = 0.94) more effectively than by 5-HT2A antagonists (r = 0.37)

Reference

Maurel-Remy; Bervoets; Millan

European Journal of Pharmacology, 1995 , vol. 280, # 2 p. R9-R11 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

sensitization of mesolimbic dopamine function

Species or TestSystem (Pharmacological Data)

Long-Evans rat


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Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

2 mg/kg

Method (Pharmacological Data)

rats (300-400 g) with partial depletion of prefrontal cortex dopamine (microinfusion of 6-hydroxydopamine); title comp.-induced sensitization (4.0 mg/kg i.p., 5 once-daily inj.) six weeks later; high-speed chronoamperometry; controlled study

Further Details (Pharmacological Data)

post-mortem levels of dopamine, dihydroxyphenylacetic acid, norepinephrine and serotonin in prefrontal cortex and nucleus accumbens of 6-hydroxydopamine-lesioned and sham-lesioned animals

Results

increase in dopamine-dependent electrochemical signal

Reference

Banks; Gratton

European Journal of Pharmacology, 1995 , vol. 282, # 1-3 p. 157 - 167 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

behavioural symptoms

Species or TestSystem (Pharmacological Data)

Long-Evans rat

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

0.5 mg/kg

Method (Pharmacological Data)

rats (300-400 g) with partial depletion of prefrontal cortex dopamine (microinfusion of 6-hydroxydopamine); title comp.-induced sensitization (1.0 mg/kg i.p., 5 once-daily inj.); challenge inj. of title comp. 5 and 13 days later; total activity counts

Results

prefrontal cortex-lesioned animals were less responsive to the first inj. of title comp. than sham-lesioned animals; after repeated daily admin., the acute locomotor response of lesioned animals was signif. greater than that of sham-lesioned animals

Reference

Banks; Gratton

European Journal of Pharmacology, 1995 , vol. 282, # 1-3 p. 157 - 167 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

drug interaction

Species or TestSystem (Pharmacological Data)

mice

Concentration (Pharmacological Data)

2 mg/kg

Method (Pharmacological Data)

title compound injected 0.5 h after 0.01 - 16 mg/kg MDL 100,907 i.p.; locomotor activity measured during 90 min test means

Further Details (Pharmacological Data)

T.I.: estimated ED50 for depressing locomotion in vehicle treated mice/ ED50 for reducing title compound stimulated locomotion; MDL 100,907 :R-(+)-α-(2,3-dimethoxyphenyl)-1-<2-(4-fluorophenylethyl)>-4-piperidinemethanol

Results

estimated ED50 for title compound induced locomotion reduction 0.08 mg/kg, for baseline locomotion reduction 7.2 mg/kg; calculated T.I.= 90

Reference

Schmidt; Sorensen; Kehne; Carr; Palfreyman

Life Sciences, 1995 , vol. 56, # 25 p. 2209 - 2222 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

cardiovascular

Species or TestSystem (Pharmacological Data)

Sprague-Dawley rat


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Sex

male

Route of Application

intravenous

Concentration (Pharmacological Data)

0.5 - 1.25 mg/kg

Method (Pharmacological Data)

rat (250-300 g) used

Further Details (Pharmacological Data)

mean arterial pressure (MAP, measured with Gold universal preamplifier), heart rate (HR), striatal dopamine (DA) release (voltammetric measurements)

Results

title comp. produced hypertension, tachycardia and increased striatal DA release

Reference

Chueh; Hsieh; Chen; Lin

Pharmacology, 1995 , vol. 51, # 4 p. 237 - 244 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

cardiovascular

Species or TestSystem (Pharmacological Data)

Sprague-Dawley rat

Sex

male

Route of Application

intravenous

Concentration (Pharmacological Data)

0.5 mg/kg

Method (Pharmacological Data)

rat (250-300 g) treated with title comp. with 10 mg/kg DL-tetrahydropalmatine (THP)

Further Details (Pharmacological Data)

mean arterial pressure (MAP, measured with Gold universal preamplifier), heart rate (HR), striatal dopamine (DA) release (voltammetric measurements)

Results

title comp. completely reversed THP-induced hypotension and bradycardia; DA release increased during combined treatment

Reference

Chueh; Hsieh; Chen; Lin

Pharmacology, 1995 , vol. 51, # 4 p. 237 - 244 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor blocking agent

Species or TestSystem (Pharmacological Data)

rat C6 glicoma cells

Method (Pharmacological Data)

in vitro; cells were transfected with pcDNA1-hDAT; pretreatment with title comp. for 10 min before add. of <3H>dopamine (20 nM, 35.1 Ci/mmol); radioligand binding assay

Further Details (Pharmacological Data)

title comp. was tested by use at least six concentration for determination of Ki value

Type (Pharmacological Data)

Ki

Value of Type (Pharmacological Data)

208 nmol/l

Reference

Eshleman; Neve; Janowsky

Journal of Pharmacology and Experimental Therapeutics, 1995 , vol. 274, # 1 p. 276 - 283 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor; binding activity


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Species or TestSystem (Pharmacological Data)

COS-7 cells

Method (Pharmacological Data)

in vitro; cells were transfected with pcDNA1-hDAT; pretreatment with title comp. for 10 min before add. of <3H>-2β-carbomethoxy-3β(4-fluorophenyl)tropane (<3H>CFT, 85.9 Ci/mmol) diluted with unlabeled comp.(1 pM to 10 μM); radioligand binding assay

Further Details (Pharmacological Data)

title comp. was tested by use at least nine concentration for determination of Ki value

Type (Pharmacological Data)

Ki

Value of Type (Pharmacological Data)

2000 nmol/l

Reference

Eshleman; Neve; Janowsky

Journal of Pharmacology and Experimental Therapeutics, 1995 , vol. 274, # 1 p. 276 - 283 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor; binding activity

Species or TestSystem (Pharmacological Data)

COS-7 cells

Method (Pharmacological Data)

in vitro; cells were transfected with pcDNA1-hDAT; pretreatment with title comp. for 10 min before add. of <3H>GBR-12935; radioligand binding assay

Further Details (Pharmacological Data)

title comp. was tested by use at least nine concentration for determination of Ki value

Type (Pharmacological Data)

Ki

Value of Type (Pharmacological Data)

4342 nmol/l

Reference

Eshleman; Neve; Janowsky

Journal of Pharmacology and Experimental Therapeutics, 1995 , vol. 274, # 1 p. 276 - 283 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

regulation of striatal cAMP

Species or TestSystem (Pharmacological Data)

Sprague-Dawley rat brain

Sex

male

Concentration (Pharmacological Data)

10 μmol/l

Method (Pharmacological Data)

in vitro; brain slices from rats (180-200 g); effects of title comp. on cAMP formation and accumulation in the presence of 3 μM sulpiride, 300 μM 1-aminocyclopentane-1s,3R-dicarboxylic acid (ACPD); radioimmunoassay

Results

title comp. and sulpiride enhanced dopamine D1 receptor induced cAMP formation in the control and in the presence of APCD, by 67 percent and 74 percent, resp.

Reference

Wang; Johnson

Journal of Pharmacology and Experimental Therapeutics, 1995 , vol. 275, # 2 p. 877 - 884 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

effects on chronotropic responses in female rat isolated atria

Reference

Fitzgerald; Reid

Journal of Pharmacy and Pharmacology, 1994 , vol. 46, # 10 p. 826 - 832 Title/Abstract Full Text View citing articles Show Details


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Effect (Pharmacological Data)

agonist

Species or TestSystem (Pharmacological Data)

swiss albino mice

Sex

male

Route of Application

subcutaneous

Concentration (Pharmacological Data)

1.25 mg/kg

Method (Pharmacological Data)

28 g mice

Further Details (Pharmacological Data)

grooming score ibolishing in the presence of L-DOPA; dopamine agonist

Results

climbing and sniffing scores were 31.6 and 57.3, respectively in mice treated with L-DOPA (75 mg/kg)

Reference

Protais; Chagraoui; Arbaoui; Mocaer

European Journal of Pharmacology, 1994 , vol. 271, # 1 p. 167 - 177 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

dystonic syndrome

Species or TestSystem (Pharmacological Data)

man

Sex

male

Method (Pharmacological Data)

a 28 year old man; drunk a whole bottle of vodka and that this had been 'spiked' with 'Whizz', a test chemical

Results

following an overdose of 'Whizz' and alcohol a protracted dystonic syndrome can developed, clinically indistinguishable from tetanus

Reference

Humphreys; Tanner

Human and Experimental Toxicology, 1994 , vol. 13, # 5 p. 311 - 312 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

acute toxicity LD50 = 13 mg/kg (mice)

Reference

Shivanyuk; Losev; Vargashkin; Bobkov; Lozinskii

Pharmaceutical Chemistry Journal, 1992 , vol. 26, # 5 p. 430 - 432 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

binding affinity at 5-HT1C and 5-HT2 serotonin receptors; lack of selectivity

Reference

Glennon, Richard A.; Raghupathi, Reva; Bartyzel, Piotr; Teitler, Milt; Leonhardt, Sigrun

Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 734 - 740 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

spasmolytical, central nervous system depressant, and antiinflammatory activity (mice)

Reference

Shivanyuk; Losev; Vargashkin; Bobkov; Lozinskii

Pharmaceutical Chemistry Journal, 1992 , vol. 26, # 5 p. 430 - 432 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

no affinity at σ binding sites (rat cerebellar homogenate), does not bind at PCP sites

Reference

Glennon, Richard A.; Smith, J. Doyle; Ismaiel, Abd M.; El-Ashmawy, Mahmoud; Battaglia, George; Fisher, James B.

Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1094 - 1098 Title/Abstract Full Text View citing articles Show Details


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Comment (Pharmacological Data)

binding affinity to 5-HT1 and 5-HT2 sites

Reference

Glennon, Richard A.; McKenney, J. D.; Lyon, Robert A.; Titeler, Milt

Journal of Medicinal Chemistry, 1986 , vol. 29, # 2 p. 194 - 199 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

LD 50: 80 mg/kg (mice, intraperitoneally)

Reference

Sarkisyan, A. B.; Solomina, L. P.; Pirdzhanov, L. Sh.; Markaryan, E. A.; Arzanunt, E. M.; et al.

Pharmaceutical Chemistry Journal, 1985 , vol. 19, # 4 p. 256 - 258 Khimiko-Farmatsevticheskii Zhurnal, 1985 , vol. 19, # 4 p. 423 - 425 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

at dose 3 mg/kg effects on apomorphine-induced (0.6 mg/kg s.c.) stereotyped behaviour (Sprague-Dawley rats)

Reference

Depin; Betbeder-Matibet; Bonhomme; Muller; Berthelon

Arzneimittel-Forschung/Drug Research, 1985 , vol. 35, # 11 p. 1655 - 1662 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

inhibition of dopamine uptake by rat striatum synaptosomes (IC 50: 6.9E-7 mol/l), at doses 1E-5 mol/l increases biogenic amines norepinephrine (2E-8 mol/l) release (222616 dpm/ml/mg tissue/10 min, rat brain cortex slices)

Reference

Depin; Betbeder-Matibet; Bonhomme; Muller; Berthelon

Arzneimittel-Forschung/Drug Research, 1985 , vol. 35, # 11 p. 1655 - 1662 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

ability to inhibit the potassium-evoked release of <3H>acetylcholine from stratial slices after depletion of dopamine stores with reserpine and α-methyl-p-tyrosine

Reference

Hamada, Akihiko; Chang, Yu An; Uretsky, Norman; Miller, Duane D.

Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 675 - 680 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

LD 50: 137 mg/kg - intraperitoneally (mice); effect on the physical endurance - intraperitoneally (rat)

Reference

Gevorkyan, K. A.; Papayan, G. L.; Shirinyan, E. A.; Atayan, T. K.; Vorskanyan, A. S.

Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 7 p. 484 - 487 Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 7 p. 806 - 808 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

antinociceptive activity: inhibition of acetylcholine writhing (mouse) ED50 = 1.6 mg/kg po, inflamed paw pressure treshold (rat) ED50 = 2.1 mg/kg po; behavioral stimulant activity

Reference

Harris; Middlemiss; Mills; Gower; Tyers

Journal of Medicinal Chemistry, 1983 , vol. 26, # 1 p. 55 - 60 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

influence on spontaneous locomotor activity (20 mg/kg, s.c., mouse)

Reference

Pittner

Arzneimittel-Forschung/Drug Research, 1983 , vol. 33, # 1 A p. 13 - 25 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

decreases the body temperature (25 mg/kg, i.p., rats), increases the exploratory activity, ED 50: 21 mg/kg (p.o., mice); inhibition of muricidal behaviour, ED50: 1.5 mg/kg p.o.; increases the locomotor activity in mice (5 mg/kg i.v.)

Reference

Jahn; Adrian; Ismail; Michos

Arzneimittel-Forschung/Drug Research, 1983 , vol. 33, # 5 p. 726 - 730 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

inhibition of norepinephrine N-methyltransferase (NMT)

Reference

Grunewald, Gary L.; Monn, James A.; Rafferty, Michael F,; Borchardt, Ronald T.; Krass, Polina

Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1248 - 1250 Title/Abstract Full Text View citing articles Show Details


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Comment (Pharmacological Data)

decreased the body mass; increased plasma free fatty acids; stimulated adrenocortical function; no effect on plasma glucose, liver glycogen and phosphorylase activity <chronic treatment of albino rats with amphetamine (4 mg/kg body mass)>

Reference

Hamdy; Fahim

Pharmazie, 1982 , vol. 37, # 3 p. 206 - 208 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

behavioral properties (discriminative stimulus) in animals

Reference

Glennon; Young; Benington; Morin

Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1163 - 1168 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

inhibition of rat pancreatic lipase

Reference

Comai; Sullivan

Journal of Pharmaceutical Sciences, 1982 , vol. 71, # 4 p. 418 - 421 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

norepinephrine N-methyltransferase (NMT) inhibition constant

Reference

Rafferty, Michael F.; Wilson, David S.; Monn, James A.; Krass, Polina; Borchardt, Ronald T.; Grunewald, Gary L.

Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1198 - 1204 Title/Abstract Full Text View citing articles Show Details

Rafferty; Borchardt; Grunewald

Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1204 - 1208 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

serum, brain, liver concentrations (rat)

Reference

Javaid; Davis

Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 7 p. 813 - 815 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

decreases the responses of the electrically stimulated guinea-pig ileum

Reference

Little; Rees

Journal of Pharmacy and Pharmacology, 1980 , vol. 32, # 11 p. 751 - 756 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

pharmacokinetics in humans: PEU, EXC

Reference

Testa; Salvesen

Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 5 p. 497 - 501 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

affinity for the serotonin receptor (rat stomach fundus preparation)

Reference

Glennon; Liebowitz; Anderson III

Journal of Medicinal Chemistry, 1980 , vol. 23, # 3 p. 294 - 299 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

inhibitor of the neuronal and extraneural binding of noradrenaline; Sprague-Dawley rat, i.v.

Reference

Jacquot; Rapin

Arzneimittel-Forschung/Drug Research, 1980 , vol. 30, # 5 p. 776 - 779 Title/Abstract Full Text View citing articles Show Details

Other Data Exposure Assessment (2) 1 of 2

Exposure

presence in surface water; Llobregat River, its main tributaries (Cardener River and Anoia River) and Rubi creek in NE Spain; sampling in


January, March and May 2007

2 of 2

Sources

human source contaminants

Reference

Huerta-Fontela, Maria; Galceran, Maria Teresa; Ventura, Francesc

Environmental Science and Technology, 2008 , vol. 42, # 18 p. 6809 - 6816 Title/Abstract Full Text View citing articles Show Details

Exposure

presence in hair and fingernails; 22-year-old male

Sources

chronic drug abuse

Reference

Cirimele; Kintz; Mangin

Archives of Toxicology, 1995 , vol. 70, # 1 p. 68 - 69 Title/Abstract Full Text View citing articles Show Details

Concentration in the Environment (13) 1 of 13

2 of 13

3 of 13

4 of 13

Media (Concentration in the Environment)

sewage water

Location

Gandia, Spain

Contamination Concentration

6.5 ng/l

Method, Remarks (Concentration in the Environment)

samples collected from STP of tourist cites of Gandia; influent 24-h composite samples collected on 26th of July 2007; solid-phase extraction-liquid chromatography-electrospray-tandem mass spectrometry

Reference

Postigo, Cristina; Lopez De Alda, Maria J.; Barcelo, Damia

Analytical Chemistry, 2008 , vol. 80, # 9 p. 3123 - 3134 Title/Abstract Full Text View citing articles Show Details

Media (Concentration in the Environment)

sewage water

Location

Gandia, Spain

Contamination Concentration

3.3 ng/l

Method, Remarks (Concentration in the Environment)

samples collected from STP of tourist cites of Gandia; effluent 24-h composite samples collected on 26th of July 2007; solid-phase extraction-liquid chromatography-electrospray-tandem mass spectrometry

Reference

Postigo, Cristina; Lopez De Alda, Maria J.; Barcelo, Damia

Analytical Chemistry, 2008 , vol. 80, # 9 p. 3123 - 3134 Title/Abstract Full Text View citing articles Show Details

Media (Concentration in the Environment)

sewage water

Location

Benicassim, Spain

Contamination Concentration

35.5 ng/l

Method, Remarks (Concentration in the Environment)

samples collected from STP of tourist cites of Benicassim; influent 24-h composite samples collected on 26th of July 2007; solid-phase extraction-liquid chromatography-electrospray-tandem mass spectrometry

Reference

Postigo, Cristina; Lopez De Alda, Maria J.; Barcelo, Damia

Analytical Chemistry, 2008 , vol. 80, # 9 p. 3123 - 3134 Title/Abstract Full Text View citing articles Show Details

Media (Concentration in the Environment)

sewage water

Location

Benicassim, Spain

Contamination Concentration

1.0 ng/l

Method, Remarks (Concentration in the Environment)

samples collected from STP of tourist cites of Benicassim; effluent 24-h composite samples collected on 26th of July 2007; solid-phase extraction-liquid chromatography-electrospray-tandem mass spectrometry

Reference

Postigo, Cristina; Lopez De Alda, Maria J.; Barcelo, Damia

Analytical Chemistry, 2008 , vol. 80, # 9 p. 3123 - 3134 Title/Abstract Full Text View citing articles Show Details


5 of 13

6 of 13

7 of 13

8 of 13

9 of 13

10 of 13

Media (Concentration in the Environment)

sewage water

Location

Valencia, Spain

Contamination Concentration

20.4 ng/l

Method, Remarks (Concentration in the Environment)

samples collected from STP of tourist cites of Valencia; influent 24-h composite samples collected on 26th of July 2007; solid-phase extraction-liquid chromatography-electrospray-tandem mass spectrometry

Reference

Postigo, Cristina; Lopez De Alda, Maria J.; Barcelo, Damia

Analytical Chemistry, 2008 , vol. 80, # 9 p. 3123 - 3134 Title/Abstract Full Text View citing articles Show Details

Media (Concentration in the Environment)

sewage water

Location

Valencia, Spain

Contamination Concentration

2.2 ng/l

Method, Remarks (Concentration in the Environment)

samples collected from STP of tourist cites of Valencia; effluent 24-h composite samples collected on 26th of July 2007; solid-phase extraction-liquid chromatography-electrospray-tandem mass spectrometry

Reference

Postigo, Cristina; Lopez De Alda, Maria J.; Barcelo, Damia

Analytical Chemistry, 2008 , vol. 80, # 9 p. 3123 - 3134 Title/Abstract Full Text View citing articles Show Details

Media (Concentration in the Environment)

sewage water

Location

Barcelona, Spain

Contamination Concentration

41.1 ng/l

Method, Remarks (Concentration in the Environment)

samples collected from major STP of Barcelona; influent 24-h composite samples collected every day during first week of July 2007; solidphase extraction-liquid chromatography-electrospray-tandem mass spectrometry

Reference

Postigo, Cristina; Lopez De Alda, Maria J.; Barcelo, Damia

Analytical Chemistry, 2008 , vol. 80, # 9 p. 3123 - 3134 Title/Abstract Full Text View citing articles Show Details

Media (Concentration in the Environment)

sewage water

Location

Barcelona, Spain

Contamination Concentration

0.5 ng/l

Method, Remarks (Concentration in the Environment)

samples collected from major STP of Barcelona; effluent 24-h composite samples collected every day during first week of July 2007; solidphase extraction-liquid chromatography-electrospray-tandem mass spectrometry

Reference

Postigo, Cristina; Lopez De Alda, Maria J.; Barcelo, Damia

Analytical Chemistry, 2008 , vol. 80, # 9 p. 3123 - 3134 Title/Abstract Full Text View citing articles Show Details

Media (Concentration in the Environment)

surface water

Location

Llobregat River, NE Spain

Contamination Concentration

5 - 90 ng/l

Method, Remarks (Concentration in the Environment)

samples collected during January to June 2007; analyzed by ultraperformance LC-ESI/MS/MS in selected reaction monitoring mode

Reference

Huerta-Fontela, Maria; Galceran, Maria Teresa; Ventura, Francesc

Environmental Science and Technology, 2008 , vol. 42, # 18 p. 6809 - 6816 Title/Abstract Full Text View citing articles Show Details

Media

surface water


(Concentration in the Environment)

11 of 13

12 of 13

13 of 13

Location

Llobregat River, NE Spain

Contamination Concentration

0.4 - 50 ng/l

Method, Remarks (Concentration in the Environment)

mean conc.; samples collected once a week every Monday and at the same time (10:00 am) during March 2006 to May 2007 at the intake of a drinking water treatment plant; analyzed by ultraperformance LC-ECI/MS/MS in selected reaction monitoring mode

Reference

Huerta-Fontela, Maria; Galceran, Maria Teresa; Ventura, Francesc

Environmental Science and Technology, 2008 , vol. 42, # 18 p. 6809 - 6816 Title/Abstract Full Text View citing articles Show Details

Media (Concentration in the Environment)

surface water

Location

Llobregat River basin, NE Spain

Contamination Concentration

0 - 50 ng/l

Method, Remarks (Concentration in the Environment)

mean conc.; samples collected over 7 consecutive days at the same time (10:00 am) during December 2006 at the intake of a drinking water treatment plant; analyzed by ultraperformance LC-ESI/MS/MS in selected reaction monitoring mode

Reference

Huerta-Fontela, Maria; Galceran, Maria Teresa; Ventura, Francesc

Environmental Science and Technology, 2008 , vol. 42, # 18 p. 6809 - 6816 Title/Abstract Full Text View citing articles Show Details

Media (Concentration in the Environment)

wastewater

Location

Nosedo (Milan), Italy

Contamination Concentration

0 - 14.7 ng/l

Method, Remarks (Concentration in the Environment)

8 water sample collected during 1 week in February 2006 from wastewater treatment plant influents and effluents; HPLC-MS-MS analyzed

Reference

Castiglioni, Sara; Zuccato, Ettore; Crisci, Elisabetta; Chiabrando, Chiara; Fanelli, Roberte; Bagnati, Renzo

Analytical Chemistry, 2006 , vol. 78, # 24 p. 8421 - 8429 Title/Abstract Full Text View citing articles Show Details

Species (Concentration in the Environment)

human

Location

United States

Contamination Concentration

0.038 - 1.019 mg/kg

Method, Remarks (Concentration in the Environment)

in meconium; 7 samples belonged to mothers who declared heavy methamphetamine abuse during pregnancy; internal standard; methanol-HCl treatment; Bond Elut Certify solid-phase extraction column; HPLC-MS; in positive ESI mode; SIM acquisition

Reference

Pichini, Simona; Pacifici, Roberta; Pellegrini, Manuela; Marchei, Emilia; Lozano, Jaime; Murillo, Janeth; Vall, Oriol; GarciaAlgar, Oscar

Analytical Chemistry, 2004 , vol. 76, # 7 p. 2124 - 2132 Title/Abstract Full Text View citing articles Show Details

Use (284) Use Pattern

Location

Reference

Pharmaceuticals

Page/Page column 22-30

JANSSEN PHARMACEUTICA NV; DVORAK, Curt A.; LIU, Changlu; KUEI, Chester

Patent: WO2014/152917 A2, 2014 ;

Page/Page column 22-30

JANSSEN PHARMACEUTICA NV; DVORAK, Curt A.; LIU, Changlu; KUEI, Chester

Patent: WO2014/152917 A2, 2014 ;

Page/Page column 22-30

JANSSEN PHARMACEUTICA NV; DVORAK, Curt A.; LIU, Changlu; KUEI, Chester

Patent: WO2014/152917 A2, 2014 ;

activating GPR139

for detecting GPR139 activation

Title/Abstract Full Text Show Details

Title/Abstract Full Text Show Details


Title/Abstract Full Text Show Details

modulating Phenylketonuria (PKU)

modulating a neurological function

dopaminergic agent for combination therapy

Page/Page column 22-30

JANSSEN PHARMACEUTICA NV; DVORAK, Curt A.; LIU, Changlu; KUEI, Chester

Patent: WO2014/152917 A2, 2014 ;

Page/Page column 22-30

JANSSEN PHARMACEUTICA NV; DVORAK, Curt A.; LIU, Changlu; KUEI, Chester

Patent: WO2014/152917 A2, 2014 ;

Acadia Pharmaceuticals, Inc.

Patent: US2009/82342 A1, 2009 ;

Title/Abstract Full Text Show Details

Title/Abstract Full Text Show Details

Title/Abstract Full Text Show Details

psychostimulant

Poestges, Reiner; Schneider, Bernd; Ammer, Richard

Patent: US2008/75769 A1, 2008 ; Title/Abstract Full Text Show Details

H. LUNDBECK A/S

Patent: WO2009/76961 A1, 2009 ; Title/Abstract Full Text Show Details

Attention Deficit Hyperactivity Disorder (ADHD)

MEMORY PHARMACEUTICALS CORPORATION

Patent: WO2005/51389 A1, 2005 ; Title/Abstract Full Text Show Details

BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG

Patent: WO2007/93624 A2, 2007 ; Title/Abstract Full Text Show Details

Poestges, Reiner; Schneider, Bernd; Ammer, Richard

Patent: US2008/75769 A1, 2008 ; Title/Abstract Full Text Show Details

narcolepsy

Kirk, Randal J.

Patent: US2006/100136 A1, 2006 ; Title/Abstract Full Text Show Details

Poestges, Reiner; Schneider, Bernd; Ammer, Richard

Patent: US2008/75769 A1, 2008 ; Title/Abstract Full Text Show Details

obesity

Kirk, Randal J.

Patent: US2006/100136 A1, 2006 ; Title/Abstract Full Text Show Details

GELESIS, INC.

Patent: WO2007/112436 A2, 2007 ; Title/Abstract Full Text Show Details

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

Anorectic agent

Nettekoven, Matthias; Plancher, Jean-Marc; Richter, Hans; Roche, Olivier; Rodriguez Sarmiento, Rosa Maria; Taylor, Sven

Patent: US2007/123526 A1, 2007 ; Title/Abstract Full Text Show Details

Nettekoven, Matthias Heinrich; Roche, Olivier

Patent: US2007/270423 A1, 2007 ; Title/Abstract Full Text Show Details

Nettekoven, Matthias; Roche, Olivier

Patent: US2008/32976 A1, 2008 ; Title/Abstract Full Text Show Details

Hebeisen, Paul; Roever, Stephan

Patent: US2008/70931 A1, 2008 ; Title/Abstract Full Text Show Details


bulimia

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ;

Title/Abstract Full Text Show Details

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

Attention Deficit Disorder (ADD)

BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG

Patent: WO2007/93624 A2, 2007 ;

Title/Abstract Full Text Show Details

Poestges, Reiner; Schneider, Bernd; Ammer, Richard

Patent: US2008/75769 A1, 2008 ; Title/Abstract Full Text Show Details

potentiating a therapeutic effect of an endogenous alpha-2 adrenergic receptor agonist

fatigue symptom associated with fibromyalgia syndrome (FMS)

Neuronal cell damage

Jhamandas, Khem; Milne, Brian

Patent: US2008/20076 A1, 2008 ; Title/Abstract Full Text Show Details

CYPRESS BIOSCIENCE, INC.

Patent: WO2008/19388 A2, 2008 ; Title/Abstract Full Text Show Details

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

Death caused by transient cerebral hypoxia

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ;

Title/Abstract Full Text Show Details

Death caused by transient cerebral ischemia

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ;

Title/Abstract Full Text Show Details

transient cerebral hypoxia

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ;

Title/Abstract Full Text Show Details

Transient ischemic condition

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ;

Title/Abstract Full Text Show Details

Show next 20

Hide facts

Use Pattern

Location

Reference

Neuronal cell damage caused by transient cerebral hypoxia

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

Neuronal cell damage caused by transient cerebral ischemia

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

cerebral hypoxic condition

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

Cerebral ischemic condition

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details


transient cerebral hypoxic condition caused by loss of blood

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

transient cerebral hypoxic condition caused by a heart attack

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

transient cerebral hypoxic condition caused by strangulation

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

transient cerebral hypoxic condition caused by surgery

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

transient cerebral hypoxic condition caused by cardiac surgery

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

transient cerebral hypoxic condition caused by stroke

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

transient cerebral hypoxic condition caused by air-way blockage

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

transient cerebral hypoxic condition caused by ischemic optic neuropathy

transient cerebral hypoxic condition caused by spinal cord injuries

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

transient cerebral hypoxic condition caused by traumatic brain injury

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

transient cerebral hypoxic condition caused by low blood pressure

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

transient cerebral ischemic condition caused by loss of blood

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

transient cerebral ischemic condition caused by a heart attack

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

transient cerebral ischemic condition caused by strangulation

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

transient cerebral ischemic condition caused by surgery

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

transient cerebral ischemic condition caused by cardiac surgery

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ;


Title/Abstract Full Text Show Details

transient cerebral ischemic condition caused by a stroke

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

transient cerebral ischemic condition caused by air-way blockage

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

transient cerebral ischemic condition caused by ischemic optic neuropathy

transient cerebral ischemic condition caused by spinal cord injuries

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

transient cerebral ischemic condition caused by traumatic brain injury

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

transient cerebral ischemic condition caused by low blood pressure

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

Neuronal cell damage due to lack of oxygen reaching the neuronal cells

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

Neuronal cell damage due to lack of glucose reaching the neuronal cells

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

Ischemic condition

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

anti-obesity agent

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

disorder associated with excessive food intake

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

obesity related disorders

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

overeating

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

elevated plasma insulin concentrations

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details


insulin resistance

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

dyslipidemias

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

hyperlipidemia

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

endometrial cancer

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

breast cancer

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

prostate cancer

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

colon cancer

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

osteoarthritis

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

obstructive sleep apnea

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

gallstones

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

abnormal heart rhythms

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

heart arrythmias

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

myocardial infarction

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

congestive heart failure

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.;


Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ;

Title/Abstract Full Text Show Details

coronary heart disease

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

sudden death

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

stroke

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

polycystic ovarian disease

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

craniopharyngioma

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

the Prader-Willi Syndrome

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

Frohlich's syndrome

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

GH-deficient subjects

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

normal variant short stature

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

Turner's syndrome

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

metabolic syndrome

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

maintaining weight loss

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

Attention Deficit Hyperactivity Disorder (ADHD) comorbidities

Poestges, Reiner; Schneider, Bernd; Ammer, Richard

Patent: US2008/75769 A1, 2008 ;


Title/Abstract Full Text Show Details

fatigue

Poestges, Reiner; Schneider, Bernd; Ammer, Richard

Patent: US2008/75769 A1, 2008 ; Title/Abstract Full Text Show Details

cognitive decline associated with systemic diseases

Poestges, Reiner; Schneider, Bernd; Ammer, Richard

Patent: US2008/75769 A1, 2008 ; Title/Abstract Full Text Show Details

acquired immunodeficiency syndrome

Poestges, Reiner; Schneider, Bernd; Ammer, Richard

Patent: US2008/75769 A1, 2008 ; Title/Abstract Full Text Show Details

oncological diseases

Poestges, Reiner; Schneider, Bernd; Ammer, Richard

Patent: US2008/75769 A1, 2008 ; Title/Abstract Full Text Show Details

active ingredient of multimodal abuse resistant pharmaceutical composition

active ingredient of multimodal extended release pharmaceutical composition

active ingredient of multimodal extended release abuse resistant pharmaceutical composition

modulate dopamine receptors; β-PEA analogue

THERAQUEST BIOSCIENCES, INC.

Patent: WO2008/33351 A2, 2008 ; Title/Abstract Full Text Show Details

THERAQUEST BIOSCIENCES, INC.

Patent: WO2008/33351 A2, 2008 ; Title/Abstract Full Text Show Details

THERAQUEST BIOSCIENCES, INC.

Patent: WO2008/33351 A2, 2008 ; Title/Abstract Full Text Show Details

BRAINCELLS, INC.

Patent: WO2008/39863 A2, 2008 ; Title/Abstract Full Text Show Details

Neurogenic agent

BRAINCELLS, INC.

Patent: WO2008/39863 A2, 2008 ; Title/Abstract Full Text Show Details

method of increasing neurogenesis

BRAINCELLS, INC.

Patent: WO2008/39863 A2, 2008 ; Title/Abstract Full Text Show Details

nervous system disorder

BRAINCELLS, INC.

Patent: WO2008/39863 A2, 2008 ; Title/Abstract Full Text Show Details

nerve cell trauma

BRAINCELLS, INC.

Patent: WO2008/39863 A2, 2008 ; Title/Abstract Full Text Show Details

psychiatric condition

BRAINCELLS, INC.

Patent: WO2008/39863 A2, 2008 ; Title/Abstract Full Text Show Details

neurological condition

BRAINCELLS, INC.

Patent: WO2008/39863 A2, 2008 ; Title/Abstract Full Text Show Details

central stimulant drug

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Patent: WO2008/63721 A2, 2008 ; Title/Abstract Full Text Show Details


central nervous system (CNS) stimulant

NEUROGESX, INC.

Patent: WO2008/70149 A2, 2008 ; Title/Abstract Full Text Show Details

Decongestant

CASE WESTERN RESERVE UNIVERSITY

Patent: WO2008/70264 A2, 2008 ; Title/Abstract Full Text Show Details

epilepsy

Tam, Peter Y.; Wilson, Leland F.

Patent: US2008/103179 A1, 2008 ; Title/Abstract Full Text Show Details

diabetes

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

Tam, Peter Y.; Wilson, Leland F.

Patent: US2008/103179 A1, 2008 ; Title/Abstract Full Text Show Details

hypertension

Amatruda, John M.; Daruwala, Paul; Erondu, Ngozi E.; MacNeil, Douglas J.; Moller, David E.; Qian, Su

Patent: US2008/64632 A1, 2008 ; Title/Abstract Full Text Show Details

Tam, Peter Y.; Wilson, Leland F.

Patent: US2008/103179 A1, 2008 ; Title/Abstract Full Text Show Details

pulmonary hypertension

Tam, Peter Y.; Wilson, Leland F.

Patent: US2008/103179 A1, 2008 ; Title/Abstract Full Text Show Details

migraine

Tam, Peter Y.; Wilson, Leland F.

Patent: US2008/103179 A1, 2008 ; Title/Abstract Full Text Show Details

sleep apnea

Cypress Bioscience, Inc.

Patent: US2006/39866 A1, 2006 ; Title/Abstract Full Text Show Details

Tam, Peter Y.; Wilson, Leland F.

Patent: US2008/103179 A1, 2008 ; Title/Abstract Full Text Show Details

depression

Kirk, Randal J.

Patent: US2006/100136 A1, 2006 ; Title/Abstract Full Text Show Details

Tam, Peter Y.; Wilson, Leland F.

Patent: US2008/103179 A1, 2008 ; Title/Abstract Full Text Show Details

impulse control disorders

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

Tam, Peter Y.; Wilson, Leland F.

Patent: US2008/103179 A1, 2008 ; Title/Abstract Full Text Show Details

alcohol addiction

Tam, Peter Y.; Wilson, Leland F.

Patent: US2008/103179 A1, 2008 ; Title/Abstract Full Text Show Details

sympathomimetic agent

Tam, Peter Y.; Wilson, Leland F.

Patent: US2008/103179 A1, 2008 ;


Title/Abstract Full Text Show Details

second agent of the composition with antiepileptic agent

Tam, Peter Y.; Wilson, Leland F.

Patent: US2008/103179 A1, 2008 ; Title/Abstract Full Text Show Details

second agent of the composition with anticonvulsant sulfamate or sulfonylurea compound

combination with milnacipran for long-term treatment of fatigue

Tam, Peter Y.; Wilson, Leland F.

Patent: US2008/103179 A1, 2008 ; Title/Abstract Full Text Show Details

Cypress Bioscience, Inc.

Patent: US2008/293820 A1, 2008 ; Title/Abstract Full Text Show Details

Norepinephrine transporter

Dopamine Transporter

monoamine transporter

Antiobesity agent

Page/Page column 12

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Patent: WO2008/13997 A2, 2008 ;

Page/Page column 12

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Patent: WO2008/13997 A2, 2008 ;

Page/Page column 12

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Patent: WO2008/13997 A2, 2008 ;

Novo Nordisk, A/S

Patent: US6972294 B1, 2005 ;

Title/Abstract Full Text Show Details

Title/Abstract Full Text Show Details

Title/Abstract Full Text Show Details

Title/Abstract Full Text Show Details

NOVO NORDISK A/S

Patent: WO2007/144394 A2, 2007 ; Title/Abstract Full Text Show Details

active ingredient to reduce appetite

LABORATORIOS DEL DR. ESTEVE, S.A.

Patent: EP1743643 A1, 2007 ; Title/Abstract Full Text Show Details

Laboratorios del Dr. Esteve S.A.

Patent: EP1745783 A1, 2007 ; Title/Abstract Full Text Show Details

Reducing appetite

LABORATORIOS DEL DR. ESTEVE, S.A.

Patent: EP1757588 A1, 2007 ; Title/Abstract Full Text Show Details

Local irritation of the gastrointestinal (GI) tract

PRAECIS PHARMACEUTICALS, INC.

Patent: WO2007/21970 A2, 2007 ; Title/Abstract Full Text Show Details

Reduced food effect

PRAECIS PHARMACEUTICALS, INC.

Patent: WO2007/21970 A2, 2007 ; Title/Abstract Full Text Show Details

Protection of the gastrointestinal tract

PRAECIS PHARMACEUTICALS, INC.

Patent: WO2007/21970 A2, 2007 ; Title/Abstract Full Text Show Details

Reduced irritating effect

PRAECIS PHARMACEUTICALS, INC.

Patent: WO2007/21970 A2, 2007 ; Title/Abstract Full Text Show Details

Taste masking

PRAECIS PHARMACEUTICALS, INC.

Patent: WO2007/21970 A2, 2007 ;


Title/Abstract Full Text Show Details

Odor masking

PRAECIS PHARMACEUTICALS, INC.

Patent: WO2007/21970 A2, 2007 ; Title/Abstract Full Text Show Details

Flavor augmentation

PRAECIS PHARMACEUTICALS, INC.

Patent: WO2007/21970 A2, 2007 ; Title/Abstract Full Text Show Details

Acidic conditions of the gastrointestinal tract

PRAECIS PHARMACEUTICALS, INC.

Patent: WO2007/21970 A2, 2007 ; Title/Abstract Full Text Show Details

Long-term therapy for fibromyalgia syndrome (FMS)

Cypress Bioscience, Inc.

Patent: US2007/72946 A1, 2007 ; Title/Abstract Full Text Show Details

Fibromyalgia

Cypress Bioscience, Inc.

Patent: US2007/72946 A1, 2007 ; Title/Abstract Full Text Show Details

Acute pain

Cypress Bioscience, Inc.

Patent: US2007/72946 A1, 2007 ; Title/Abstract Full Text Show Details

Long-term therapy of a pain symptom associated with fibromyalgia syndrome

Appetite regulating agent

Cypress Bioscience, Inc.

Patent: US2007/72946 A1, 2007 ; Title/Abstract Full Text Show Details

IRM LLC

Patent: WO2007/89557 A2, 2007 ; Title/Abstract Full Text Show Details

IRM LLC

Patent: WO2007/89667 A1, 2007 ; Title/Abstract Full Text Show Details

attention deficit disorders (ADD, also known as attention deficit hyperactivity disorder or ADHD)

cognitive improvement agent

Wyeth

Patent: US2007/225334 A1, 2007 ; Title/Abstract Full Text Show Details

Wyeth

Patent: US2007/225278 A1, 2007 ; Title/Abstract Full Text Show Details

Wyeth

Patent: US2007/225334 A1, 2007 ; Title/Abstract Full Text Show Details

attention deficit disorders/attention Deficit Hyperactivity Disorder (ADD/ADHD) agent

adrenoceptor agonist

Wyeth

Patent: US2007/225278 A1, 2007 ; Title/Abstract Full Text Show Details

BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG

Patent: WO2007/93624 A2, 2007 ; Title/Abstract Full Text Show Details

Attention Deficit Hyperactivity Disorder (ADHD) predominantly impulsivity type

BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG

Patent: WO2007/93624 A2, 2007 ; Title/Abstract Full Text Show Details

Attention Deficit Hyperactivity Disorder (ADHD) predominantly

BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER


INGELHEIM PHARMA GMBH and CO. KG

Patent: WO2007/93624 A2, 2007 ;

inattentive type

Title/Abstract Full Text Show Details

Attention Deficit Hyperactivity Disorder (ADHD) predominantly hyperactive-impulsive type

BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG

Patent: WO2007/93624 A2, 2007 ; Title/Abstract Full Text Show Details

Attention Deficit Hyperactivity Disorder (ADHD) predominantly not otherwise specified

BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG

Patent: WO2007/93624 A2, 2007 ; Title/Abstract Full Text Show Details

appetite suppresant; antiobesity agent

GELESIS, INC.

Patent: WO2007/112436 A2, 2007 ; Title/Abstract Full Text Show Details

enhancing gastric retention

GELESIS, INC.

Patent: WO2007/112436 A2, 2007 ; Title/Abstract Full Text Show Details

controlled drug delivery

GELESIS, INC.

Patent: WO2007/112436 A2, 2007 ; Title/Abstract Full Text Show Details

inducing weight loss

GELESIS, INC.

Patent: WO2007/112436 A2, 2007 ; Title/Abstract Full Text Show Details

gastrointestinal disorders

GELESIS, INC.

Patent: WO2007/112436 A2, 2007 ; Title/Abstract Full Text Show Details

Anorexia

Nettekoven, Matthias Heinrich; Roche, Olivier

Patent: US2007/270423 A1, 2007 ; Title/Abstract Full Text Show Details

Antiobesity agent in combination

NOVO NORDISK A/S

Patent: WO2007/135111 A1, 2007 ; Title/Abstract Full Text Show Details

Anti-obesity agent

IRM LLC

Patent: WO2005/113506 A1, 2005 ; Title/Abstract Full Text Show Details

NOVARTIS AG; NOVARTIS PHARMA GmbH

Patent: WO2007/41366 A1, 2007 ; Title/Abstract Full Text Show Details

IRM LLC

Patent: WO2007/89557 A2, 2007 ; Title/Abstract Full Text Show Details

IRM LLC

Patent: WO2007/89667 A1, 2007 ; Title/Abstract Full Text Show Details

IRM LLC

Patent: WO2005/113519 A1, 2005 ; Title/Abstract Full Text Show Details

Anorectic agent

Page/Page column 16

Nettekoven, Matthias; Plancher, Jean-Marc; Richter, Hans; Roche, Oliver; Runtz-Schmitt, Valerie; Taylor, Sven

Patent: US2007/123515 A1, 2007 ; Title/Abstract Full Text Show Details


Anorectic agent

Page/Page column 14

Nettekoven, Matthias; Plancher, Jean-Marc; Richter, Hans; Roche, Olivier; Taylor, Sven

Patent: US2007/123525 A1, 2007 ; Title/Abstract Full Text Show Details

identifying a modulator of N-methyl-D-aspartate (NMDA) receptor function

agent that reduces phosphorylation of an NMDA receptor complex

deCODE Genetics, Inc.

Patent: US2006/29546 A1, 2006 ; Title/Abstract Full Text Show Details

deCODE Genetics, Inc.

Patent: US2006/29546 A1, 2006 ; Title/Abstract Full Text Show Details

stimulant

Renshaw, Perry F.; Cohen, Bruce M.

Patent: US2006/39890 A1, 2006 ; Title/Abstract Full Text Show Details

Kirk, Randal J.

Patent: US2006/100136 A1, 2006 ; Title/Abstract Full Text Show Details

sleep related breathing disorder

Cypress Bioscience, Inc.

Patent: US2006/39866 A1, 2006 ; Title/Abstract Full Text Show Details

therapy

Cypress Bioscience, Inc.

Patent: US2006/39866 A1, 2006 ; Title/Abstract Full Text Show Details

pharmaceutical composition

Cypress Bioscience, Inc.

Patent: US2006/39866 A1, 2006 ; Title/Abstract Full Text Show Details

combination therapy

Cypress Bioscience, Inc.

Patent: US2006/39866 A1, 2006 ; Title/Abstract Full Text Show Details

daytime drowsiness

Cypress Bioscience, Inc.

Patent: US2006/39866 A1, 2006 ; Title/Abstract Full Text Show Details

cause release of norepinephrine

Davis, Michael; Ressler, Kerry J.; Chhatwal, Jasmeer P.; McDevitt, Jason P.

Patent: US2006/84659 A1, 2006 ; Title/Abstract Full Text Show Details

pharmacologic agent increases the level of norepinephrine in the brain

Davis, Michael; Ressler, Kerry J.; Chhatwal, Jasmeer P.; McDevitt, Jason P.

Patent: US2006/84659 A1, 2006 ; Title/Abstract Full Text Show Details

Anoretic agent

Nettekoven, Matthias Heinrich; Plancher, Jean-Marc; Roche, Olivier; Rodriguez-Sarmiento, Rosa Maria

Patent: US2006/160855 A1, 2006 ; Title/Abstract Full Text Show Details

Antiobesity

CENGENT THERAPEUTICS, INC.

Patent: WO2006/78698 A1, 2006 ; Title/Abstract Full Text Show Details

Dopamine agonist

CLERA INC.

Patent: WO2006/84368 A1, 2006 ; Title/Abstract Full Text Show Details

Dopamine mimetic

CLERA INC.

Patent: WO2006/84368 A1, 2006 ;


Title/Abstract Full Text Show Details

Increasing availability of serotonin

THE SILVAN S. TOMKINS INSTITUTE

Patent: WO2006/91725 A1, 2006 ; Title/Abstract Full Text Show Details

Increasing efficiency of serotonin

THE SILVAN S. TOMKINS INSTITUTE

Patent: WO2006/91725 A1, 2006 ; Title/Abstract Full Text Show Details

stimulant effect on the central nervous system

The Research Foundation of the City University of New York; New York University

Patent: US7112319 B2, 2006 ; Title/Abstract Full Text Show Details

Stimulant

The Research Foundation of the City University of New York; New York University

Patent: US7112319 B2, 2006 ; Title/Abstract Full Text Show Details

Psychomotor stimulant

ABBOTT GMBH and CO.KG

Patent: WO2006/40177 A1, 2006 ; Title/Abstract Full Text Show Details

antiobesity agent

NOVO NORDISK A/S

Patent: WO2006/40329 A1, 2006 ; Title/Abstract Full Text Show Details

central-nervous-system stimulant

Kulli, John C.

Patent: US2006/257323 A1, 2006 ; Title/Abstract Full Text Show Details

autism

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

compulsivity

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

impulsivity

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

Asperger's syndrome

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

attention deficit disorder

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

Kirk, Randal J.

Patent: US2006/100136 A1, 2006 ; Title/Abstract Full Text Show Details

attention deficit hyperactivity disorder

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

Kirk, Randal J.

Patent: US2006/100136 A1, 2006 ; Title/Abstract Full Text Show Details


obsessive-compulsive disorder

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

Tourette's syndrome

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

body dismorphic disorder

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

hypochondriasis

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

eating disorders

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

paraphilias sexual addictions

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

nonparaphilic sexual addictions

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

Sydeham's chorea

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

torticollis

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

intermittent explosive disorder

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

kleptomania

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

pathological gambling

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

pyromania

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

compulsive shopping

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

compulsive buying

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

repetitive self-mutilation

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ;


Title/Abstract Full Text Show Details

onychophagia

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

psychogenic excoriation

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

trichotillomania

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

anorexia nervosa

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

binge eating

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

sexual compulsion

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

alcohol and substance use disorders

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

neurological disorders with disinhibition or frontal lobe deficits

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

bipolar disorder

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

childhood onset bipolar disorder

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

serotonin reuptake inhibitor

MOUNT SINAI SCHOOL OF MEDICINE

Patent: WO2006/34187 A2, 2006 ; Title/Abstract Full Text Show Details

Page/Page column 87-88

ABBOTT GMBH and CO. KG

Patent: WO2006/40180 A1, 2006 ;

Page/Page column 32

NOVO NORDISK A/S

Patent: WO2006/120178 A1, 2006 ;

Pharmaceutically active agent in oral osmotic pharmaceutical delivery dosage form

Kidane, Argaw; Ray, Shimul K.; Bhatt, Padmanabh P.; Bryan, Jones W.

Patent: US2005/53653 A1, 2005 ;

active ingredient of pharmaceutical formulation

Psychomotor stimulant

antiobesity agent

Title/Abstract Full Text Show Details

Title/Abstract Full Text Show Details

Title/Abstract Full Text Show Details

RANBAXY LABORATORIES LIMITED

Patent: WO2005/44238 A1, 2005 ; Title/Abstract Full Text Show Details


modulating central norepinephrine and dopamine receptors through the promotion of catecholamine release

PFIZER PRODUCTS INC.

Patent: WO2005/61506 A1, 2005 ; Title/Abstract Full Text Show Details

PFIZER PRODUCTS INC.

Patent: WO2005/61507 A1, 2005 ; Title/Abstract Full Text Show Details

Adrenergic agent

PFIZER PRODUCTS INC.

Patent: WO2005/61506 A1, 2005 ; Title/Abstract Full Text Show Details

PFIZER PRODUCTS INC.

Patent: WO2005/61507 A1, 2005 ; Title/Abstract Full Text Show Details

Type 2 diabetes mellitus

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Insulin resistance

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Syndrome X

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Hypertension including hypertension in the elderly

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Familial dyslipidemic hypertension

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Isolated systolic hypertension(ISH)

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Increased collagen formation

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Fibrosis

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Remodeling following hypertension

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Erectile dysfunction

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Impaired vascular compliance

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Stroke

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details


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Congestive heart failure

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Left ventricular hypertrophy

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Survival post myocardial infarction(MI)

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Coronary artery diseases

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Atherosclerosis

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Angina pectoris

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Thrombosis

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Renal failure

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Chronic renal failure

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Glomerulosclerosis

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Nephropathy

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Hypothyroidism

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Endothelial dysfunction with or without hypertension

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Hyperlipidemia

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Hyperlipoproteinemia

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details


Hypertryglyceridemia

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Hypercholesterolemia

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Macular degeneration

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Cataract

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Glaucoma

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Skin and connective tissue disorders

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Restenosis after percutaneous transluminal angioplasty

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Restenosis after coronary artery bypass surgery

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Peripheral vascular disease

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Reproductive disorders

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Pulmonary disease

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Gallstones

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Fasting-inducedcholecystitis

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Cancers

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Cutaneous disease

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Cushing's syndrome

NOVARTIS AG; NOVARTIS PHARMA GMBH


Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Insulinoma

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Craniopharyngioma

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

Premenstrual syndrome

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

dopamine releaser

DESCARTES THERAPEUTICS, INC.

Patent: WO2005/107467 A2, 2005 ; Title/Abstract Full Text Show Details

Dopaminergic agent for composition for treating pain

DESCARTES THERAPEUTICS, INC.

Patent: WO2005/107467 A2, 2005 ; Title/Abstract Full Text Show Details

Dopaminergic agent for composition for treating nociception

DESCARTES THERAPEUTICS, INC.

Patent: WO2005/107467 A2, 2005 ; Title/Abstract Full Text Show Details

inflammation and discomfort within the nasal passages or throat

Wasson, Allan Anthony

Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details

laryngitis

Wasson, Allan Anthony

Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details

tracheitis

Wasson, Allan Anthony

Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details

nasal secretions

Wasson, Allan Anthony

Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details

watery eyes

Wasson, Allan Anthony

Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details

cough

Wasson, Allan Anthony

Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details

tracheobroncheal involvement

Wasson, Allan Anthony

Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details

pneumonia

Wasson, Allan Anthony

Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details

viral allergies

Wasson, Allan Anthony

Patent: US2005/277697 A1, 2005 ;


Title/Abstract Full Text Show Details

flu-like or viral infection

Wasson, Allan Anthony

Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details

adverse effects of an air-born allergen

Wasson, Allan Anthony

Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details

bronchitis

Wasson, Allan Anthony

Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details

runny nose

Wasson, Allan Anthony

Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details

sneezing

Wasson, Allan Anthony

Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details

viral-induced malaise

Wasson, Allan Anthony

Patent: US2005/277697 A1, 2005 ; Title/Abstract Full Text Show Details

Obesity

NOVARTIS AG; NOVARTIS PHARMA GMBH

Patent: WO2005/49088 A2, 2005 ; Title/Abstract Full Text Show Details

SEED, John, C.

Patent: WO2005/51297 A2, 2005 ; Title/Abstract Full Text Show Details

Achieving desirable weight loss

SEED, John, C.

Patent: WO2005/51297 A2, 2005 ; Title/Abstract Full Text Show Details

Overweight

SEED, John, C.

Patent: WO2005/51297 A2, 2005 ; Title/Abstract Full Text Show Details

Preventing undesirable weight gain

SEED, John, C.

Patent: WO2005/51297 A2, 2005 ; Title/Abstract Full Text Show Details

Reducing body weight

SEED, John, C.

Patent: WO2005/51297 A2, 2005 ; Title/Abstract Full Text Show Details

Maintaining stable weight

SEED, John, C.

Patent: WO2005/51297 A2, 2005 ; Title/Abstract Full Text Show Details

Depression

SEED, John, C.

Patent: WO2005/51297 A2, 2005 ; Title/Abstract Full Text Show Details

Alzheimer's disease

SEED, John, C.

Patent: WO2005/51297 A2, 2005 ; Title/Abstract Full Text Show Details

Anorexiant

SEED, John, C.


Patent: WO2005/51297 A2, 2005 ; Title/Abstract Full Text Show Details

active drug for pharmaceutical drug resin conjugate

Thassu, Deepak; Hafey, Paul

Patent: US2005/142097 A1, 2005 ; Title/Abstract Full Text Show Details

biologically active agent for preparation of hydroxyalkyl derivatives with improved bioavailability, bioefficacy and reduced side effects

KOPRAN RESEARCH LABORATORIES LIMITED

Patent: WO2005/105153 A1, 2005 ; Title/Abstract Full Text Show Details

Appetite-regulating agent

IRM LLC

Patent: WO2005/113506 A1, 2005 ; Title/Abstract Full Text Show Details

IRM LLC

Patent: WO2005/113519 A1, 2005 ; Title/Abstract Full Text Show Details


Turn static files into dynamic content formats.

Create a flipbook
Issuu converts static files into: digital portfolios, online yearbooks, online catalogs, digital photo albums and more. Sign up and create your flipbook.