1-Phenylpropan-2-amine (Amphetamine) by Asch

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Reactions (84)

Yield

Substances (1)

Citations (104)

Conditions

References

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Rx-ID: 780136 Find similar reactions

95%

With palladium 10 on activated carbon; ammonium formate in methanol; water

T=20°C;

Vahermo, Mikko; Suominen, Tina; Leinonen, Antti; Yli-Kauhaluoma, Jari

Archiv der Pharmazie, 2009 , vol. 342, # 4 p. 201 - 209 Title/Abstract Full Text View citing articles Show Details

92%

With 2,5dimethylbenzylamine; molybdenum(V) chloride in ethyl acetate

T=68°C; P=21002.1 Torr; 2.5 h; Sealed tubeLarge scale; TemperaturePressure; Hide Experimental Procedure

Chengdu Chester Technology Co., Ltd.; Peng, Fei

Patent: CN106083600 A, 2016 ; Location in patent: Paragraph 0020; 0021; 0022; 0023 ; Title/Abstract Full Text Show Details

1:Example 1

A method for synthesizing 1-phenyl-2-aminopropane as an intermediate for amphetamines, comprising the steps of:A, 8.3mol of phenylacetone, 10.2mol of molybdenum chloride powder, 40wtpercent of molybdenum chloride in high pressure reactor2, 5-dimethylbenzylamine solution 2L, mass fraction of 47percent ethyl acetone acetone solution 1.9L, sealed reaction container, remove the emptyGas, raising the temperature of the solution to 68 , raising the pressure of the vessel to 2.8MPa, reacting for 150min;B, reduce the solution temperature to 16 , remove the air, filter, filtrate 0.9kPa vacuum distillation, collecting 70-76 Fractions, 83percent nitromethane solution washing, the mass fraction of 85percent pyridine solution washing, anhydrous calcium sulfate dehydration, And then recrystallized in 89percent ethylenediamine solution to obtain 1030.86 g of 1-phenyl-2-aminopropane.Rate of 92percent. 80%

With ammonium formate; palladium on activated charcoal in methanol

T=20°C;

Gonzalez-Sabin, Javier; Gotor, Vicente; Rebolledo, Francisca

Tetrahedron Asymmetry, 2002 , vol. 13, # 12 p. 1315 - 1320 Title/Abstract Full Text View citing articles Show Details

69%

1.4 g

With palladium 10 on activated carbon; ammonium formate in methanol; water

T=20°C;

Martínez-Montero, Lía; Díaz-Rodríguez, Alba; Gotor, Vicente; Gotor-Fernández, Vicente; Lavandera, Iván

Green Chemistry, 2015 , vol. 17, # 5 p. 2794 - 2798 Title/Abstract Full Text View citing articles Show Details

With methanol; ammonia; nickel

T=65°C; Hydrogenation.unter Druck;

Mastagli et al.

Bulletin de la Societe Chimique de France, 1950 , p. 1045 Full Text Show Details

With methanol; ammonia; nickel

Hydrogenation;

Couturier

Annales de Chimie (Cachan, France), 1938 , vol. <11> 10, p. 559,597 Full Text Show Details

With ethanol; ammonia; zinc

Harlay

Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1941 , vol. 213, p. 304 Full Text Show Details

With ammonium acetate; sodium cyanoborohydride

Schultz, Arthur G.; Kirincich, Steven J.; Rahm, Rainer

Tetrahedron Letters, 1995 , vol. 36, # 26 p. 4551 - 4554 Title/Abstract Full Text View citing articles Show Details

With ammonium acetate; sodium cyanoborohydride in methanol

Viswanathan, Rajesh; Prabhakaran, Erode N.; Plotkin, Michael A.; Johnston, Jeffrey N.

Journal of the American Chemical Society, 2003 , vol. 125, # 1 p. 163 - 168 Title/Abstract Full Text View citing articles Show Details

With ammonium formate

Leuckart reaction;

Bahajaj; Vernon; Wilson

Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 12 p. 1446 - 1451 Title/Abstract Full Text View citing articles Show Details

With ammonium acetate; sodium cyanoborohydride in methanol

T=20°C; reductive amination;

Kinbara, Kazushi; Harada, Yoshiko; Saigo, Kazuhiko

Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 7 p. 1339 - 1347 Title/Abstract Full Text View citing articles Show Details

Multi-step reaction with 3 steps 1: N2H4+H2O; methanol 2: platinum; ethanolic HCl / Hydrogenation 3: Raney nickel; ethanol / Hydrogenation View Scheme

Biel et al.

Journal of the American Chemical Society, 1959 , vol. 81, p. 2805,2810, 2813 Full Text View citing articles Show Details

Multi-step reaction with 2 steps 1: N2H4+H2O; methanol 2: Raney nickel; ethanol / Hydrogenation View Scheme

Biel et al.

Journal of the American Chemical Society, 1959 , vol. 81, p. 2805,2810, 2813 Full Text View citing articles Show Details

Multi-step reaction with 2 steps 1: aqueous NaOH; hydroxylamine hydrochloride 2: sodium-amalgam; aqueous acetic acid View Scheme

Hey

Journal of the Chemical Society, 1930 , p. 18,20 Full Text Show Details

With ammonium acetate; sodium cyanoborohydride in methanol

T=20°C; 36 h;

Collins, Michael; Salouros, Helen; Cawley, Adam T.; Robertson, James; Heagney, Aaron C.; Arenas-Queralt, Andrea

Rapid Communications in Mass Spectrometry, 2010 , vol. 24, # 11 p. 1653 - 1658 Title/Abstract Full Text View citing articles Show Details

Multi-step reaction with 2 steps 1: titanium(IV) isopropylate; ammonia / methanol / 6 h / 20 °C / Inert atmosphere 2: sodium tetrahydroborate / methanol / 3 h / 20 °C

Munoz, Lourdes; Rodriguez, Anna M.; Rosell, Gloria; Bosch, M. Pilar; Guerrero, Angel

Organic and Biomolecular Chemistry, 2011 , vol. 9, # 23 p. 8171 - 8177 Title/Abstract Full Text View citing articles Show Details

View Scheme

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Rx-ID: 1040192 Find similar reactions

91%

With sodium tetrahydroborate; boraneTHF in tetrahydrofuran

T=25°C; 144 h;

Kabalka, George W.; Laila Guindi; Varma, Rajender S.

Tetrahedron, 1990 , vol. 46, # 21 p. 7443 - 7457 Title/Abstract Full Text View citing articles Show Details

77%

With lithium aluminium tetrahydride in tetrahydrofuran; diethyl ether

2 h; Heating;

Smith, Roger A.; White, Robert L.; Krantz, Allen

Journal of Medicinal Chemistry, 1988 , vol. 31, # 8 p. 1558 - 1566 Title/Abstract Full Text View citing articles Show Details

77%

With lithium aluminium tetrahydride in diethyl ether

3 h; Inert atmosphereReflux;

Munoz, Lourdes; Rodriguez, Anna M.; Rosell, Gloria; Bosch, M. Pilar; Guerrero, Angel

Organic and Biomolecular Chemistry, 2011 , vol. 9, # 23 p. 8171 - 8177 Title/Abstract Full Text View citing articles Show Details

65%

With hydrogenchloride; aluminium; nickel dichloride in ethanol; water

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES; Grison, Claude; Escarre, Jose

Patent: US9149796 B2, 2015 ; Location in patent: Page/Page column 49; 50 ;

Hide Experimental Procedure

Title/Abstract Full Text Show Details

8:Example 8 Reduction of 1-phenyl 2-nitroprene in 1-phenyl 2-aminopropane

This method illustrates an application of the method in the double reduction of a C═C double bond and the nitro group. (0588) 2.5 g of 1-phenyl 2-nitropropene are placed in 25 mL of ethanol then added to an ethanolic nickel solution (2 g NiCl2 (Example 5.2) in 50 ml of EtOH). (0589) 1.5 mL of hydrochloric acid are added slowly, then 10.5 grams of aluminium are introduced slowly. After dissolution of the aluminium, 4 mL of HCl then 0.8 g of aluminium are added alternately. (0590) Repeat this successive addition of HCl and aluminium twice. (0591) The consumption of the aluminium is slow and needs 5 to 6 hours of reaction. The medium is then neutralized carefully using an aqueous soda solution. The reaction is highly exothermic. (0592) After 30 minutes, the organic phase becomes orange, which indicates the formation of the expected amine. After decantation and concentration, the crude syrup obtained is taken up in acetone. (0593) The addition of sulphuric acid precipitates the ammonium sulphate derived from the 1-phenyl 2-aminopropane, which is isolated by filtration. The overall yield of 1-phenyl 2-aminopropane is 65percent. 65%

With hydrogenchloride; hydrogen; nickel in ethanol; water

Hide Experimental Procedure

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES; GRISON, Claude; ESCANDE, Vincent

Patent: US2015/376224 A1, 2015 ; Location in patent: Paragraph 0787-0793 ; Title/Abstract Full Text Show Details

This method illustrates an application of the method in the double reduction of a C=C double bond and the nitro group.2.5 g of 1-phenyl 2-nitropropene are placed in 25 mL of ethanol then added to an ethanolic nickel solution (2NiC12 (Reference Example 5.2) in 50 ml of EtOR). 1.5 mL of hydrochloric acid are added slowly, then 10.5 grams of aluminium are introduced slowly. After dissolution of the aluminium, 4 mL of HC1 then 0.8 g of aluminium are added alternately.Repeat this successive addition of HC1 and aluminium twice.The consumption of the aluminium is slow and needs 5 to 6 hours ofreaction. The medium is then neutralized carefully using an aqueous soda solution. The reaction is highly exothermic.After 30 minutes, the organic phase becomes orange, which indicates the formation of the expected amine. Afier decantation and concentration, the crude syrup obtained is taken up in acetone.The addition of sulphuric acid precipitates the ammonium sulphate derived from the 1-phenyl 2-aminopropane, which is isolated by filtration. The overall yield of 1 -phenyl 2-aminopropane is 65percent. 60%

With sulfuric acid in water; isopropyl alcohol

T=10 - 15°C; electrolysis;

Wessling, Michael; Schaefer, Hans J.

Chemische Berichte, 1991 , vol. 124, # 10 p. 2303 - 2306 Title/Abstract Full Text Show Details

With hydrogen; platinum(IV) oxide in ethanol

Iwai; Tomita; Ide

Chemical and pharmaceutical bulletin, 1965 , vol. 13, # 2 p. 118 - 129 Title/Abstract Full Text View citing articles Show Details

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; boraneTHF

1.) 25 deg C, 6 days, 2.) 60 -65 deg C, 2 h, 3.) NaOH; Yield given. Multistep reaction;

Mourad, M. Soubei; Varma, Rajender S.; Kabalka, George W.

Synthetic Communications, 1984 , vol. 14, # 12 p. 1099 - 1104 Title/Abstract Full Text Show Details

1.86 g

With hydrogenchloride; sodium tetrahydroborate; boron trifluoride diethyl etherate

1.) THF, reflux, 5.5 h, 2.) heating, 2 h; Yield given. Multistep reaction;

Varma, Rajender S.; Kabalka, George W.

Synthetic Communications, 1985 , vol. 15, # 9 p. 843 - 848 Title/Abstract Full Text Show Details

With lithium aluminium tetrahydride in diethyl ether

1.) reflux, 6 h, 2.) RT, 16 h;

Glennon, Richard A.; Raghupathi, Reva; Bartyzel, Piotr; Teitler, Milt; Leonhardt, Sigrun

Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 734 - 740 Title/Abstract Full Text View citing articles Show Details

With lithium aluminium tetrahydride in tetrahydrofuran

3 h; Heating;

Kinderman, Sape S.; Wekking, Monique M. T.; Van Maarseveen, Jan H.; Schoemaker, Hans E.; Hiemstra, Henk; Rutjes, Floris P. J. T.

Journal of Organic Chemistry, 2005 , vol. 70, # 14 p. 5519 - 5527 Title/Abstract Full Text View citing articles Show Details

With platinum(IV) oxide; hydrogen in ethanol; acetic acid

P=2378.94 Torr; 3 h;

Collins, Michael; Salouros, Helen; Cawley, Adam T.; Robertson, James; Heagney, Aaron C.; Arenas-Queralt, Andrea

Rapid Communications in Mass Spectrometry, 2010 , vol. 24, # 11 p. 1653 - 1658 Title/Abstract Full Text View citing articles Show Details

Synthesize Find similar 90%

65 % Chromat.

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Rx-ID: 2046518 Find similar reactions

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; laccase from Trametes versicolor; oxygen in aq. buffer T=30°C; pH=5; 16 h; Enzymatic reaction;

Martínez-Montero, Lía; Díaz-Rodríguez, Alba; Gotor, Vicente; Gotor-Fernández, Vicente; Lavandera, Iván

Green Chemistry, 2015 , vol. 17, # 5 p. 2794 - 2798 Title/Abstract Full Text View citing articles Show Details

Rate constant;

Testa; Salvesen

Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 5 p. 497 - 501 Title/Abstract Full Text View citing articles Show Details

With hydrogen; palladium on activated charcoal

Hydrogenolysis;

Hartung, Christian G.; Breindl, Claudia; Tillack, Annegret; Beller, Matthias

Tetrahedron, 2000 , vol. 56, # 29 p. 5157 - 5162 Title/Abstract Full Text View citing articles Show Details

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Rx-ID: 37474415 Find similar reactions

Multi-step reaction with 2 steps 1: O-(2,4-dinitro-phenyl)-hydroxylamine; [Rh2(α,α,α′,α′-tetramethyl-1,3benzenedipropionate)2] / 2,2,2-trifluoroethanol / 14 h / -10 °C 2: palladium on activated charcoal; hydrogen / methanol / 16 h / 20 °C View Scheme

Jat, Jawahar L.; Paudyal, Mahesh P.; Gao, Hongyin; Xu, Qing-Long; Yousufuddin, Muhammed; Devarajan, Deepa; Ess, Daniel H.; Kurti, Laszlo; Falck, John R.

Science, 2014 , vol. 343, # 6166 p. 61 - 65 Title/Abstract Full Text View citing articles Show Details

Multi-step reaction with 2 steps 1: [Rh2(α,α,α′,α′-tetramethyl-1,3benzenedipropionate)2]; O-(2,4-dinitrophenyl)-hydroxylamine / 2,2,2-trifluoroethanol / 14 h / -10 °C / |Inert atmosphere 2: palladium 10 on activated carbon; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr / |Inert atmosphere View Scheme

ESS, Daniel, Halsell; FALCK, John, Russell; JAT, Jawahar, Lal; URTI, Laszlo

Patent: WO2015/103505 A2, 2015 ; Title/Abstract Full Text Show Details

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With palladium 10 on activated carbon; hydrogen in methanol

T=20°C; P=760.051 Torr; 16 h; Inert atmosphere; Hide Experimental Procedure

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Rx-ID: 40479771 Find similar reactions

ESS, Daniel, Halsell; FALCK, John, Russell; JAT, Jawahar, Lal; URTI, Laszlo

Patent: WO2015/103505 A2, 2015 ; Location in patent: Page/Page column 66 ; Title/Abstract Full Text Show Details

l-Phenylpropan-2-amine: A suspension of (is)-2-methyl-3-phenylaziridine 12c (20 mg, 0.15 mmol) and 10percent Pd/C (10 mg) in MeOH (1 mL) was stirred under a hydrogen atmosphere (1 atm) at rt for 16 h. The reaction mixture was filtered by passage through a small pad of Celite™. The pad was washed with methanol and the combined filtrates were evaporated to furnish the title amine as an oil (19 mg, 96percent). *H NMR (500 MHz, CDC13) δ 8.46 (br s, 2H), 7.34-7.20 (m, 5H), 3.65-3.53 (m, 1H), 3.27 (dd, J= 13.4, 5.1 Hz, 1H), 2.87 (dd, J= 13.3, 9.1 Hz, 1H), 1.39 (d, J= 6.4 Hz, 3H); 13C NMR (126 MHz, CDC13) δ 135.83, 129.35, 128.87, 127.26, 49.80, 41.07, 18.13.

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With palladium on activated charcoal; hydrogen in methanol

T=20°C; 16 h;

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Rx-ID: 37474416 Find similar reactions

Jat, Jawahar L.; Paudyal, Mahesh P.; Gao, Hongyin; Xu, Qing-Long; Yousufuddin, Muhammed; Devarajan, Deepa; Ess, Daniel H.; Kurti, Laszlo; Falck, John R.

Science, 2014 , vol. 343, # 6166 p. 61 - 65 Title/Abstract Full Text View citing articles Show Details

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64%

With O-Methylhydroxylamin; nbutyllithium in tetrahydrofuran; hexane

T=-78 - 60°C; 20 h; Cooling with iceInert atmosphere;

Rx-ID: 38460613 Find similar reactions

Hong, Kai; Liu, Xun; Morken, James P.

Journal of the American Chemical Society, 2014 , vol. 136, # 30 p. 10581 - 10584 Title/Abstract Full Text View citing articles Show Details

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Rx-ID: 8618017 Find similar reactions

65%

Stage #1: With resin-bound CH2OCONHCOOtBu; diethylazodicarboxylate in tetrahydrofuran

Solid phase reaction; Mitsunobu reaction; 12 h; Stage #2: With trifluoroacetic acid in 1,2dichloro-ethane

Decarboxylation; 4 h;

Subramanyam

Tetrahedron Letters, 2000 , vol. 41, # 34 p. 6537 - 6540 Title/Abstract Full Text View citing articles Show Details

Multi-step reaction with 2 steps 1: 85 percent / diphenyl-2-pyridylphosphine; di-tert-butyl azodicarboxylate / CH2Cl2 / 2 h / 20 °C 2: 84 percent / PhSH; potassium carbonate / acetonitrile / 50 °C View Scheme

Guisado, Cristina; Waterhouse, Jodie E.; Price, Wayne S.; Jorgensen, Michael R.; Miller, Andrew D.

Organic and Biomolecular Chemistry, 2005 , vol. 3, # 6 p. 1049 - 1057 Title/Abstract Full Text View citing articles Show Details

76 %Chromat.

With Ru3(CO)12; ammonia; N-phenyl-2(dicyclohexylphosphino)pyrrol in tert-Amyl alcohol

T=150°C; 20 h; Cooling with dry iceMolecular sieve; chemoselective reaction;

Imm, Sebastian; Neubert, Lorenz; Neumann, Helfried; Beller, Matthias

Angewandte Chemie - International Edition, 2010 , vol. 49, # 44 p. 8126 - 8129 Title/Abstract Full Text View citing articles Show Details

Hide Details

85 %Chromat.

With ammonia in 5,5-dimethyl-1,3cyclohexadiene

T=20 - 160°C; P=3000.3 Torr; 20 h; Sealed tubeAutoclave;

Shimizu, Ken-Ichi; Kon, Kenichi; Onodera, Wataru; Yamazaki, Hiroshi; Kondo, Junko N.

ACS Catalysis, 2013 , vol. 3, # 1 p. 112 - 117 Title/Abstract Full Text View citing articles Show Details

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Rx-ID: 20915502 Find similar reactions

Multi-step reaction with 2 steps 1: n-BuNH2 / ethanol / Heating; or HOAc, NH4OAc 2: 60 percent / 0.3 M H2SO4 / propan-2-ol; H2O / 10 - 15 °C / electrolysis View Scheme

Wessling, Michael; Schaefer, Hans J.

Chemische Berichte, 1991 , vol. 124, # 10 p. 2303 - 2306 Title/Abstract Full Text Show Details

Multi-step reaction with 2 steps 1: ammonium acetate / 1.) reflux, 8 h, 2.) RT, 60 h 2: LiAlH4 / diethyl ether / 1.) reflux, 6 h, 2.) RT, 16 h View Scheme

Glennon, Richard A.; Raghupathi, Reva; Bartyzel, Piotr; Teitler, Milt; Leonhardt, Sigrun

Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 734 - 740 Title/Abstract Full Text View citing articles Show Details

Multi-step reaction with 2 steps 1: Clostridium innocuum, M10 broth / 120 h / 37 °C 2: Clostridium innocuum, medium for anaerobic bacteria / 72 h / 37 °C View Scheme

Mori; Ishiyama; Akita; Suzuki; Mitsuoka; Oishi

Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 12 p. 3449 - 3451 Title/Abstract Full Text View citing articles Show Details

Hide Details

Multi-step reaction with 2 steps 1: ammonium acetate / Reflux 2: lithium aluminium tetrahydride / diethyl ether / 3 h / Inert atmosphere; Reflux View Scheme

Munoz, Lourdes; Rodriguez, Anna M.; Rosell, Gloria; Bosch, M. Pilar; Guerrero, Angel

Organic and Biomolecular Chemistry, 2011 , vol. 9, # 23 p. 8171 - 8177 Title/Abstract Full Text View citing articles Show Details

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With sodium tetrahydroborate in methanol

T=20°C; 3 h;

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Rx-ID: 32451895 Find similar reactions

Munoz, Lourdes; Rodriguez, Anna M.; Rosell, Gloria; Bosch, M. Pilar; Guerrero, Angel

Organic and Biomolecular Chemistry, 2011 , vol. 9, # 23 p. 8171 - 8177 Title/Abstract Full Text View citing articles Show Details

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With hydrogen; palladium 10 on activated carbon in methanol; ethanol

Product distribution / selectivity; Hide Experimental Procedure

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Rx-ID: 29449074 Find similar reactions

Johnson Matthey Public Limited Company

Patent: US2010/125146 A1, 2010 ; Location in patent: Page/Page column 3 ; Title/Abstract Full Text Show Details

2:Amphetamine

EXAMPLE 2 Amphetamine A mixture of 6.00 g (33.9 mmol) rac-cis-4-methyl-5-phenyl-2-oxazolidinone, 0.34 g 10percent palladium-on-carbon (50percent water wet), and 60 mL SDA-3A was stirred under a hydrogen filled balloon at ambient temperature until no more oxazolidinone was detected by HPLC (7 h). The reaction mixture was then filtered through a pad of Celite to remove the catalyst.

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100%

With 5 Pd(II)/C(eggshell); hydrogen in tetrahydrofuran

T=20°C; P=1 Torr; 3 h;

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Rx-ID: 29474953 Find similar reactions

Schulze, Matthias

Synthetic Communications, 2010 , vol. 40, # 10 p. 1461 - 1476 Title/Abstract Full Text View citing articles Show Details

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Synthesize Find similar Rx-ID: 29908327 Find similar reactions

With lithium hydroxide hydrate in N,Ndimethyl-formamide

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Bornholdt, Jan; Felding, Jakob; Clausen, Rasmus P.; Kristensen, Jesper L.

Chemistry - A European Journal, 2010 , vol. 16, # 41 p. 12474 - 12480

T=20°C; Inert atmosphere;

Title/Abstract Full Text View citing articles Show Details

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Rx-ID: 29189895 Find similar reactions

Stage #1: T=165 - 170°C; Stage #2: With water; sodium hydroxide

2 h; Reflux; Further stages;

Kunalan, Vanitha; Daeid, Niamh Nic; Kerr, William J.; Buchanan, Hilary A. S.; McPherson, Allan R.

Analytical Chemistry, 2009 , vol. 81, # 17 p. 7342 - 7348 Title/Abstract Full Text View citing articles Show Details

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Rx-ID: 29189896 Find similar reactions

A: 69%

With aluminum amalgam; sodium hydroxide in methanol

T=-10 - 60°C; 1.5 h;

Kunalan, Vanitha; Daeid, Niamh Nic; Kerr, William J.; Buchanan, Hilary A. S.; McPherson, Allan R.

Analytical Chemistry, 2009 , vol. 81, # 17 p. 7342 - 7348 Title/Abstract Full Text View citing articles Show Details

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52%

With samarium diiodide; water; isopropylamine in tetrahydrofuran

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Rx-ID: 1553468 Find similar reactions

Ankner, Tobias; Hilmersson, Goeran

Tetrahedron Letters, 2007 , vol. 48, # 32 p. 5707 - 5710 Title/Abstract Full Text View citing articles Show Details

With Clostridium innocuum; medium for anaerobic bacteria

T=37°C; 72 h;

Mori; Ishiyama; Akita; Suzuki; Mitsuoka; Oishi

Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 12 p. 3449 - 3451 Title/Abstract Full Text View citing articles Show Details

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92%

With samarium diiodide; water; isopropylamine in tetrahydrofuran

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Rx-ID: 11133977 Find similar reactions

Ankner, Tobias; Hilmersson, Goeran

Tetrahedron Letters, 2007 , vol. 48, # 32 p. 5707 - 5710 Title/Abstract Full Text View citing articles Show Details

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With lithium aluminium tetrahydride; sulfuric acid

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Rx-ID: 11117702 Find similar reactions

Armellin, Silvia; Brenna, Elisabetta; Frigoli, Samuele; Fronza, Giovanni; Fuganti, Claudio; Mussida, Daniele

Analytical Chemistry, 2006 , vol. 78, # 9 p. 3113 - 3117 Title/Abstract Full Text View citing articles Show Details

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Multi-step reaction with 2 steps 1: acetic acid; ammonium acetate 2: lithium aluminum hydride; sulfuric acid View Scheme

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Rx-ID: 11469587 Find similar reactions

Armellin, Silvia; Brenna, Elisabetta; Frigoli, Samuele; Fronza, Giovanni; Fuganti, Claudio; Mussida, Daniele

Analytical Chemistry, 2006 , vol. 78, # 9 p. 3113 - 3117 Title/Abstract Full Text View citing articles Show Details

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84%

With potassium carbonate; thiophenol in acetonitrile

T=50°C;

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Rx-ID: 9996512 Find similar reactions

Guisado, Cristina; Waterhouse, Jodie E.; Price, Wayne S.; Jorgensen, Michael R.; Miller, Andrew D.

Organic and Biomolecular Chemistry, 2005 , vol. 3, # 6 p. 1049 - 1057 Title/Abstract Full Text View citing articles Show Details

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Multi-step reaction with 2 steps 1: ammonium acetate / 2 h / Heating 2: 1.86 g / LiAlH4 / tetrahydrofuran / 3 h / Heating View Scheme

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Rx-ID: 13010064 Find similar reactions

Kinderman, Sape S.; Wekking, Monique M. T.; Van Maarseveen, Jan H.; Schoemaker, Hans E.; Hiemstra, Henk; Rutjes, Floris P. J. T.

Journal of Organic Chemistry, 2005 , vol. 70, # 14 p. 5519 - 5527 Title/Abstract Full Text View citing articles Show Details

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66%

Stage #1: With acetic anhydride; acetic acid

2 h; Stage #2: With hydrogen; palladium 10 on activated carbon

22 h; Product distribution / selectivity;

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Rx-ID: 23249684 Find similar reactions

BOEHRINGER INGELHEIM CHEMICALS INC

Patent: JP2005/507936 A, 2005 ; Location in patent: Page/Page column 16-17 ; Title/Abstract Full Text Show Details

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C: 57%

Stage #1: With acetic anhydride; acetic acid

T=20 - 84°C; Stage #2: With hydrogen; palladium 10 on activated carbon

T=20 - 55°C; P=157.516 - 2430.24 Torr; 6 h;

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BOEHRINGER INGELHEIM CHEMICALS INC

Patent: JP2005/507936 A, 2005 ; Location in patent: Page/Page column 15 ; Title/Abstract Full Text Show Details

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58%

42.8%

With hydrogen; palladium 10 on activated carbon

Product distribution / selectivity;

With hydrogen; ammonium formate; palladium 10 on activated carbon

Product distribution / selectivity;

With hydrogen; palladium 10 on activated carbon in ethanol; water

Product distribution / selectivity;

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Rx-ID: 23249688 Find similar reactions

BOEHRINGER INGELHEIM CHEMICALS INC

Patent: JP2005/507936 A, 2005 ; Location in patent: Page/Page column 20-21 ; Title/Abstract Full Text Show Details

BOEHRINGER INGELHEIM CHEMICALS INC

Patent: JP2005/507936 A, 2005 ; Location in patent: Page/Page column 20-21 ; Title/Abstract Full Text Show Details

BOEHRINGER INGELHEIM CHEMICALS INC

Patent: JP2005/507936 A, 2005 ; Location in patent: Page/Page column 18-19 ; Title/Abstract Full Text Show Details

Hide Details

With hydrogen; ammonium formate; palladium 10 on activated carbon in methanol

Product distribution / selectivity;

BOEHRINGER INGELHEIM CHEMICALS INC

Patent: JP2005/507936 A, 2005 ; Location in patent: Page/Page column 19-20 ; Title/Abstract Full Text Show Details

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With hydrogen; palladium 10 on activated carbon in water; acetic acid

Product distribution / selectivity;

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BOEHRINGER INGELHEIM CHEMICALS INC

Patent: JP2005/507936 A, 2005 ; Location in patent: Page/Page column 18-19 ; Title/Abstract Full Text Show Details

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D: 88.8%

With ammonium formate; palladium 10 on activated carbon in water

T=20 - 68°C; Product distribution / selectivity;

BOEHRINGER INGELHEIM CHEMICALS INC

Patent: JP2005/507936 A, 2005 ; Location in patent: Page/Page column 17 ;

With hydrogen; palladium 10 on activated carbon in water

Product distribution / selectivity;

BOEHRINGER INGELHEIM CHEMICALS INC

Patent: JP2005/507936 A, 2005 ; Location in patent: Page/Page column 18-19 ;

With hydrogen; ammonium formate; palladium 10 on activated carbon in water

Product distribution / selectivity;

Title/Abstract Full Text Show Details

BOEHRINGER INGELHEIM CHEMICALS INC

Patent: JP2005/507936 A, 2005 ; Location in patent: Page/Page column 19-20 ; Title/Abstract Full Text Show Details

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Synthesize Find similar Rx-ID: 23249691 Find similar reactions

C: 65.33%

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With hydrogen; palladium 10 on activated carbon in water

P=210.021 - 2842.78 Torr; 2 h; Product distribution / selectivity;

BOEHRINGER INGELHEIM CHEMICALS INC

Patent: JP2005/507936 A, 2005 ; Location in patent: Page/Page column 17-18 ;

With hydrogen; ammonium formate; palladium 10 on activated carbon in methanol; water

Product distribution / selectivity;

BOEHRINGER INGELHEIM CHEMICALS INC

Patent: JP2005/507936 A, 2005 ; Location in patent: Page/Page column 19-20 ;

Title/Abstract Full Text Show Details

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Multi-step reaction with 2 steps 1.1: CuI / diethyl ether; petroleum ether / cooling 1.2: diethyl ether; petroleum ether / -78 °C 2.1: NaBH3CN; NH4OAc / methanol View Scheme

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Rx-ID: 14528000 Find similar reactions

Viswanathan, Rajesh; Prabhakaran, Erode N.; Plotkin, Michael A.; Johnston, Jeffrey N.

Journal of the American Chemical Society, 2003 , vol. 125, # 1 p. 163 - 168 Title/Abstract Full Text View citing articles Show Details

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Rx-ID: 9178684 Find similar reactions

With tris(triphenylphosphine)ruthenium(II) chloride; hydrogen in toluene

T=125 - 150°C; P=14710.2 Torr; 24 h;

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Li, Yanjun; Izumi, Taeko

Journal of the Chinese Chemical Society (Taipei, Taiwan), 2002 , vol. 49, # 4 p. 505 - 508 Title/Abstract Full Text View citing articles Show Details

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Multi-step reaction with 2 steps 1: 63 percent / NH4OAc / 5 h / Heating 2: RuCl2(PPh3)3; H2 / toluene / 24 h / 125 150 °C / 14710.2 Torr View Scheme

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Rx-ID: 14479352 Find similar reactions

Li, Yanjun; Izumi, Taeko

Journal of the Chinese Chemical Society (Taipei, Taiwan), 2002 , vol. 49, # 4 p. 505 - 508 Title/Abstract Full Text View citing articles Show Details

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With hydrogen; palladium on activated charcoal in tetrahydrofuran

T=25°C; Catalytic hydrogenation; P=760.051 Torr; 72 h;

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Rx-ID: 8645163 Find similar reactions

Haak, Edgar; Siebeneicher, Holger; Doye, Sven

Organic Letters, 2000 , vol. 2, # 13 p. 1935 - 1937 Title/Abstract Full Text View citing articles Show Details

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Rx-ID: 8877147 Find similar reactions

With potassium phosphate buffer; NADHH+; human liver microsomes

T=37°C; pH=6.3; 0.5 h; Enzyme kinetics; Further Variations:Reagents;

Clement; Behrens; Moller; Cashman

Chemical Research in Toxicology, 2000 , vol. 13, # 10 p. 1037 - 1045 Title/Abstract Full Text View citing articles Show Details

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Multi-step reaction with 2 steps 1: Cp2TiMe2 / toluene / 72 h / 110 °C 2: H2 / Pd/C / tetrahydrofuran / 72 h / 25 °C / 760.05 Torr View Scheme

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Rx-ID: 15757170 Find similar reactions

Haak, Edgar; Siebeneicher, Holger; Doye, Sven

Organic Letters, 2000 , vol. 2, # 13 p. 1935 - 1937 Title/Abstract Full Text View citing articles Show Details

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Rx-ID: 5058065 Find similar reactions

23%

With lithium in diethyl ether

Barbier reaction; Heatingsonication;

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Gyenes, Ferenc; Bergmann, Kathryn E.; Welch, John T.

Journal of Organic Chemistry, 1998 , vol. 63, # 9 p. 2824 - 2828 Title/Abstract Full Text View citing articles Show Details

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90%

With sodium in ethanol

Heating;

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Rx-ID: 668825 Find similar reactions

Riddell, Frank G.; Rogerson, Martin

Journal of the Chemical Society. Perkin Transactions 2, 1997 , # 2 p. 249 - 255

Title/Abstract Full Text View citing articles Show Details

With ethanol; nickel

T=25°C; P=95616 Torr; Hydrogenation;

Purdue Research Found

Patent: US2233823 , 1939 ;

With sodium amalgam; acetic acid

Full Text Show Details

Hey

Journal of the Chemical Society, 1930 , p. 18,20 Full Text Show Details

Hide Details

With ammonium hydroxide; zinc

With ethanol; nickel

T=80°C; P=91938.4 Torr; Hydrogenation;

Hass et al.

Journal of Organic Chemistry, 1950 , vol. 15, p. 8,13 Full Text Show Details

With lithium aluminium tetrahydride; diethyl ether

Larsson

Chalmers Handl., 1950 , # 94 p. 21,26 Full Text Show Details

Harlay

Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1941 , vol. 213, p. 304 Full Text Show Details

With ethanol; sodium

Jaeger; van Dijk

Proceedings of the Koninklijke Nederlandse Akademie van Wetenschappen, Series B: Physical Sciences, 1941 , vol. 44, p. 26,36,37 Full Text Show Details

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Synthesize Find similar Rx-ID: 4487694 Find similar reactions

With ammonium acetate; magnesium in methanol; water

T=20 - 25°C; Yield given. Yields of byproduct given;

Micovic, Ivan V.; Ivanovic; Roglic, Goran M.; Kiricojevic, Vesna D.; Popovic, Jelena B.

Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 3 p. 265 - 269 Title/Abstract Full Text View citing articles Show Details

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With 4-(N,Ndimethlyamino)pyridine; trifluoromethylsulfonic anhydride; ammonia

1.) CH2Cl2, from -30 deg C to RT, 2.) THF, from -30 deg C to RT; Multistep reaction;

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Rx-ID: 4442992 Find similar reactions

Bell; Cantrell; Hogberg; Jaskunas; Johansson; Jordan; Kinnick; Lind; Morin Jr.; Noreen; Oberg; Palkowitz; Parrish; Pranc; Sahlberg; Ternansky; Vasileff; Vrang; West; et al.

Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4929 - 4936 Title/Abstract Full Text View citing articles Show Details

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Hide Experimental Procedure

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Rx-ID: 24435902 Find similar reactions

Matsushita Electric Industrial Co., Ltd.

Patent: US5243074 A1, 1993 ; Title/Abstract Full Text Show Details

3:EXAMPLE 3

EXAMPLE 3 In the same manner as in Example 1 but using N-(4-aminobutyl)amphetamine in place of N-(4-aminobutyl)methamphetamine, there was produced N-(4-dansylaminobutyl)amphetamine of the formula: STR4 A

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Synthesize Find similar Rx-ID: 2040169 Find similar reactions

D: 58 % Chromat.

With lithium methanolate; hydrogen; [Rh(μCl)(2,5-norbornadiene)]2; (+)-1,2bis(diphenylphosphino)propane in methanol; ethanol

T=60°C; P=51714.8 Torr; 16 h;

Harsy, Stephen G.

Tetrahedron, 1990 , vol. 46, # 21 p. 7403 - 7412 Title/Abstract Full Text View citing articles Show Details

D: 58 % Chromat.

With lithium methanolate; hydrogen; [Rh(μCl)(2,5-norbornadiene)]2; (+)-1,2bis(diphenylphosphino)propane in ethanol

T=60°C; P=51714.8 Torr; 16 h; other catalysts; Product distributionMechanism;

Harsy, Stephen G.

Tetrahedron, 1990 , vol. 46, # 21 p. 7403 - 7412 Title/Abstract Full Text View citing articles Show Details

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Rx-ID: 2677945 Find similar reactions

B: 0.52 mg C: 0.13 mg D: 0.011 mg

With Clostridium innocuum; M10 broth

T=37°C; 120 h;

Mori; Ishiyama; Akita; Suzuki; Mitsuoka; Oishi

Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 12 p. 3449 - 3451 Title/Abstract Full Text View citing articles Show Details

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With sodium in ethanol

4 h; Heating;

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Rx-ID: 2564008 Find similar reactions

Jilek, Jiri; Urban, Jiri; Taufmann, Petr; Holubek, Jiri; Dlabac, Antonin; et al.

Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 7 p. 1995 - 2008 Title/Abstract Full Text Show Details

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Rx-ID: 3899664 Find similar reactions

With hydrogenchloride; lithium diisopropyl amide

1.) 5 min. THF 2.) 12 h, RT, 3.) 2-3 d, reflux; Multistep reaction;

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Hornback, Joseph M.; Murugaverl, Balasingam

Tetrahedron Letters, 1989 , vol. 30, # 43 p. 5853 - 5856 Title/Abstract Full Text View citing articles Show Details

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Multi-step reaction with 2 steps 1: TiCl4 / toluene / 12 h 2: 1.) LDA, 3.) c.HCl / 1.) 5 min. THF 2.) 12 h, RT, 3.) 2-3 d, reflux View Scheme

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Rx-ID: 20690945 Find similar reactions

Hornback, Joseph M.; Murugaverl, Balasingam

Tetrahedron Letters, 1989 , vol. 30, # 43 p. 5853 - 5856 Title/Abstract Full Text View citing articles Show Details

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Multi-step reaction with 4 steps 1: EtONa, HCl / 1)2 hrs. reflux, ethanol, toluen, 2)0 deg C, pH=2-3, water 2: 65 percent / H3PO4 / H2O / 8 h / Heating 3: 75 percent / hydroxylamine hydrochloride / ethanol / 3 h / Heating 4: Na / ethanol / 4 h / Heating View Scheme

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Rx-ID: 21366394 Find similar reactions

Jilek, Jiri; Urban, Jiri; Taufmann, Petr; Holubek, Jiri; Dlabac, Antonin; et al.

Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 7 p. 1995 - 2008 Title/Abstract Full Text Show Details

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Multi-step reaction with 2 steps 1: 75 percent / hydroxylamine hydrochloride / ethanol / 3 h / Heating 2: Na / ethanol / 4 h / Heating View Scheme

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Rx-ID: 21372354 Find similar reactions

Jilek, Jiri; Urban, Jiri; Taufmann, Petr; Holubek, Jiri; Dlabac, Antonin; et al.

Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 7 p. 1995 - 2008 Title/Abstract Full Text Show Details

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Multi-step reaction with 3 steps 1: 65 percent / H3PO4 / H2O / 8 h / Heating 2: 75 percent / hydroxylamine hydrochloride / ethanol / 3 h / Heating 3: Na / ethanol / 4 h / Heating View Scheme

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Rx-ID: 21374973 Find similar reactions

Jilek, Jiri; Urban, Jiri; Taufmann, Petr; Holubek, Jiri; Dlabac, Antonin; et al.

Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 7 p. 1995 - 2008 Title/Abstract Full Text Show Details

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Multi-step reaction with 2 steps 1: 70 percent / butylamine 2: 77 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 2 h / Heating View Scheme

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Smith, Roger A.; White, Robert L.; Krantz, Allen

Journal of Medicinal Chemistry, 1988 , vol. 31, # 8 p. 1558 - 1566 Title/Abstract Full Text View citing articles Show Details

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Herstellung von (+-)-1-Methyl-2-phenyl<2-14C>aethylamin;

Rx-ID: 19079894 Find similar reactions

Rx-ID: 5855895 Find similar reactions

Wilson

Org.Synth.Isotopes, 1958 , p. 512 Full Text Show Details

Cervinka,O. et al.

Hide Experimental Procedure

Collection of Czechoslovak Chemical Communications, 1968 , vol. 33, p. 3551 - 3557 Full Text View citing articles Show Details

Kindler,K.; Luehrs,K.

Justus Liebigs Annalen der Chemie, 1967 , vol. 707, p. 26 - 34 Full Text View citing articles Show Details

ELSLAGER; WEINSTEIN; WORTH

Journal of medicinal chemistry, 1964 , vol. 7, p. 493 - 500 Title/Abstract Full Text View citing articles Show Details

Kotera,K. et al.

Tetrahedron, 1968 , vol. 24, p. 5677 - 5690 Full Text View citing articles Show Details

Biela,R. et al.

Journal fuer Praktische Chemie (Leipzig), 1966 , vol. 33, p. 282 - 292 Full Text View citing articles Show Details

Bose; Raychaudhuri

Journal of the Indian Chemical Society, 1961 , vol. 38, p. 217,219 Full Text Show Details

Mousseron et al.

Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1960 , vol. 250, p. 786 Full Text Show Details

Humbert; Laurent

Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1971 , vol. 272, p. 1165 Full Text Show Details

Landor et al.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1974 , p. 1294,1299 Full Text Show Details

Landor et al.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1974 , p. 1902 Full Text Show Details

Kliger et al.

Neftekhimiya, 1977 , vol. 17, p. 602,605 Chem.Abstr., 1978 , vol. 88, # 22040 Full Text Show Details

Gal et al.

Acta Pharmaceutica Suecica, 1977 , vol. 14, p. 335,340 Full Text Show Details

Prajsnar

Zeszyty Naukowe Politechniki Slaskiej, Chemia, 1963 , vol. 20, p. 1,72 Full Text Show Details

Christol et al.

Bulletin de la Societe Chimique de France, 1961 , p. 2317 Full Text Show Details

Boulassier; Chatelus

Annales de Chimie (Cachan, France), 1972 , vol. 7, # 14 p. 169,172,173 Full Text Show Details

Milstein

Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 339 Full Text Show Details

Kotera et al.

Tetrahedron Letters, 1967 , p. 841 Full Text Show Details

Sumitomo Chemical Company, Limited

Patent: US4698421 A1, 1987 ; Title/Abstract Full Text Show Details

Examples of the aliphatic amines are: Methylamine ... 4-Methylbenzylamine N-methylbenzylamine 2-Phenylethylamine 1-Phenylethylamine 1-Phenyl-2-propylamine Cyclohexylamine N-Methylcyclohexylamine N-(2-Hydroxyethyl)-cyclohexylamine ... Hide Details

Hide Experimental Procedure

Syva Company

Patent: US3966744 A1, 1976 ; Title/Abstract Full Text Show Details

3.4.A:[4'-(1"-Phenyl-2"-propylamino)crotonamido]-2,2,5,5-tetramethylpyrrolidinyl-1-oxyl

A. Amphetamine sulfate (2.76 g) was treated with 2N-sodium hydroxide solution and dichloromethane to give free amphetamine (2.03 g)

Hide Experimental Procedure

Syva Company

Patent: US3966744 A1, 1976 ; Title/Abstract Full Text Show Details

3.5.A:3-[5'-(1"-Phenyl-2"-propylamino)pentanamido]-2,2,5,5-tetramethylpyrridolinyl-1-oxyl

A. Amphetamine sulfate (2.34 g, 0.0133 mole) was treated with 2N sodium hydroxide solution and dichloromethane to give free amphetamine (1.8 g).

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With hydrogenchloride; hydrogen; palladium on activated charcoal in ethanol

T=50°C; P=760 Torr; Yield given;

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Rx-ID: 3581197 Find similar reactions

Baldwin, Jack E.; Adlington, Robert M.; Newington, Ian M.

Journal of the Chemical Society, Chemical Communications, 1986 , # 2 p. 176 - 178 Title/Abstract Full Text View citing articles Show Details

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Multi-step reaction with 3 steps 1: 99 percent 2: trifluoroacetic acid / 25 °C 3: conc. aq. HCl, H2 / 10percent Pd/C / ethanol / 50 °C / 760 Torr View Scheme

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Rx-ID: 19033257 Find similar reactions

Baldwin, Jack E.; Adlington, Robert M.; Newington, Ian M.

Journal of the Chemical Society, Chemical Communications, 1986 , # 2 p. 176 - 178 Title/Abstract Full Text View citing articles Show Details

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Multi-step reaction with 2 steps 1: trifluoroacetic acid / 25 °C 2: conc. aq. HCl, H2 / 10percent Pd/C / ethanol / 50 °C / 760 Torr View Scheme

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Rx-ID: 19051147 Find similar reactions

Baldwin, Jack E.; Adlington, Robert M.; Newington, Ian M.

Journal of the Chemical Society, Chemical Communications, 1986 , # 2 p. 176 - 178 Title/Abstract Full Text View citing articles Show Details

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Synthesize Find similar Rx-ID: 2173152 Find similar reactions

With pyridixamine phosphate

T=30°C; 20 h; pH 9.0. aromatic L-amino acid decarboxylase from Micrococcus percitreus;

Nakazawa, Hidetsugu; Kumagai, Hidehiko; Yamada, Hideaki

Agricultural and Biological Chemistry, 1985 , vol. 49, # 1 p. 159 - 166 Title/Abstract Full Text Show Details

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Synthesize Find similar Rx-ID: 1553386 Find similar reactions

With G6P; glucose-6-phosphatdegydrogenase; rat liver mitochondria enzyme; NADP; magnesium chloride in water

T=37°C; 1 h; relative activity; Rate constant;

Blume

Arzneimittel-Forschung/Drug Research, 1981 , vol. 31, # 5 p. 805 - 809 Title/Abstract Full Text View citing articles Show Details

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With NH4OH-NH4Cl buffer; pyridoxal 5'phosphate

T=30°C; 0.5 h; relative rate of CO2 evolution by aromatic L-amino acid decarboxylase from Micrococcus percitreus;

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Rx-ID: 2173151 Find similar reactions

Nakazawa, Hidetsugu; Kumagai, Hidehiko; Yamada, Hideaki

Agricultural and Biological Chemistry, 1981 , vol. 45, # 11 p. 2543 - 2552 Title/Abstract Full Text Show Details

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Rate constant;

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Rx-ID: 1553385 Find similar reactions

Testa; Salvesen

Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 5 p. 497 - 501 Title/Abstract Full Text View citing articles Show Details

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Rate constant;

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Rx-ID: 2130824 Find similar reactions

Testa; Salvesen

Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 5 p. 497 - 501 Title/Abstract Full Text View citing articles Show Details

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Rate constant;

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Rx-ID: 2131305 Find similar reactions

Testa; Salvesen

Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 5 p. 497 - 501 Title/Abstract Full Text View citing articles Show Details

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Rate constant;

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Rx-ID: 2131341 Find similar reactions

Testa; Salvesen

Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 5 p. 497 - 501 Title/Abstract Full Text View citing articles Show Details

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Rate constant;

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Rx-ID: 2131643 Find similar reactions

Testa; Salvesen

Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 5 p. 497 - 501 Title/Abstract Full Text View citing articles Show Details

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Rate constant;

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Rx-ID: 2189961 Find similar reactions

Testa; Salvesen

Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 5 p. 497 - 501 Title/Abstract Full Text View citing articles Show Details

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With hydrogen; platinum(IV) oxide in ethanol

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Rx-ID: 1118362 Find similar reactions

Iwai; Tomita; Ide

Chemical and pharmaceutical bulletin, 1965 , vol. 13, # 2 p. 118 - 129 Title/Abstract Full Text View citing articles Show Details

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Multi-step reaction with 2 steps 1: NOCl / CCl4

2: H2 / PtO2 / ethanol View Scheme

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Rx-ID: 22767624 Find similar reactions

Iwai; Tomita; Ide

Chemical and pharmaceutical bulletin, 1965 , vol. 13, # 2 p. 118 - 129 Title/Abstract Full Text View citing articles Show Details

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Rx-ID: 357907 Find similar reactions

With platinum on activated charcoal; diethyl ether

Hydrogenation;

Temmler-Werke

Patent: DE870265 , 1941 ;

With ethanol; nickel

Hydrogenation;

Biel et al.

Journal of the American Chemical Society, 1959 , vol. 81, p. 2805,2810, 2813 Full Text View citing articles Show Details

Multi-step reaction with 2 steps 1: platinum; ethanolic HCl / Hydrogenation 2: Raney nickel; ethanol / Hydrogenation View Scheme

Biel et al.

Journal of the American Chemical Society, 1959 , vol. 81, p. 2805,2810, 2813 Full Text View citing articles Show Details

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Full Text Show Details

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With ethanol; nickel

Hydrogenation;

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Rx-ID: 437864 Find similar reactions

Biel et al.

Journal of the American Chemical Society, 1959 , vol. 81, p. 2805,2810, 2813 Full Text View citing articles Show Details

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Rx-ID: 357602 Find similar reactions

With nickel

Miles Labor.Inc.

Patent: US2797243 , 1953 ; Full Text Show Details

Smith,Kline and French Labor.

Patent: US2608583 , 1949 ; Full Text Show Details

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Rx-ID: 6681954 Find similar reactions

Product distribution;

Gilsdorf; Nord

Journal of the American Chemical Society, 1952 , vol. 74, p. 1837,1841 Full Text View citing articles Show Details

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Rx-ID: 673499 Find similar reactions

anschliessend mit Aluminium-NickelLegierung;

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Fusco; Canonica

Chimica e l'Industria (Milan, Italy), 1950 , vol. 32, p. 208 Full Text Show Details

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Rx-ID: 5855899 Find similar reactions

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With methanol; nickel; acetic acid

T=40 100°C; P=51485.6 Torr; Hydrogenation;

With lithium aluminium tetrahydride; diethyl ether

With methanol; nickel

T=20 - 50°C; P=36775.4 58840.6 Torr; Hydrogenation;

Comm.Solv.Corp.

Patent: US2636901 , 1949 ; Full Text Show Details

Erne; Ramirez

Helvetica Chimica Acta, 1950 , vol. 33, p. 912,915 Full Text View citing articles Show Details

BASF

Patent: DE848197 , 1944 ; DRP/DRBP Org.Chem. Full Text Show Details

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With water; hypodiphosphonic acid; sodium nitrite

Rx-ID: 5855896 Find similar reactions

Kornblum; Iffland

Journal of the American Chemical Society, 1949 , vol. 71, p. 2137,2138,2140 Full Text View citing articles Show Details

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With sulfuric acid; palladium; acetic acid

Hydrogenation;

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Rx-ID: 281755 Find similar reactions

Kindler; Hedemann; Schaerfe

Justus Liebigs Annalen der Chemie, 1948 , vol. 560, p. 215,219 Full Text Show Details

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With hydrogenchloride

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Rx-ID: 438766 Find similar reactions

Ritter; Kalish

Journal of the American Chemical Society, 1948 , vol. 70, p. 4048 Organic Syntheses, 1964 , vol. 44, p. 44,45 Full Text View citing articles Show Details

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Synthesize Find similar Rx-ID: 780137 Find similar reactions

With ethanol; ammonia; nickel

Hydrogenation;

Haskelberg

Journal of the American Chemical Society, 1948 , vol. 70, p. 2811 Full Text View citing articles Show Details

With methanol; ammonium chloride; ammonia; platinum

Hydrogenation;

Alexander; Misegades

Journal of the American Chemical Society, 1948 , vol. 70, p. 1315 Full Text View citing articles Show Details

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Multi-step reaction with 2 steps 1: sulfuric acid / Eintraegen des Reaktionsgemisches in wss.Natronlauge 2: aqueous hydrochloric acid

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Rx-ID: 22031097 Find similar reactions

Ritter; Kalish

Journal of the American Chemical Society, 1948 , vol. 70, p. 4048 Organic Syntheses, 1964 , vol. 44, p. 44,45 Full Text View citing articles Show Details

View Scheme

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With ethanol; ammonia

T=160°C;

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Rx-ID: 436370 Find similar reactions

Patrick; McBee; Hass

Journal of the American Chemical Society, 1946 , vol. 68, p. 1009 Full Text View citing articles Show Details

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Multi-step reaction with 2 steps 1: FeCl3 / -10 °C 2: ethanol; ammonia / 160 °C View Scheme

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Rx-ID: 22154163 Find similar reactions

Patrick; McBee; Hass

Journal of the American Chemical Society, 1946 , vol. 68, p. 1009 Full Text View citing articles Show Details

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With pyridine; sodium azide; benzene

anschliessend mit wss.Salzsaeure;

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Rx-ID: 438150 Find similar reactions

Vargha; Gyoerffy

Magyar chem.FolyoiratChem.Abstr., 1944 , vol. 50, p. 6,8 Magyar chem.FolyoiratChem.Abstr., 1948 , p. 1219 Full Text Show Details

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Rx-ID: 5855897 Find similar reactions

With alkaline aqueous sodium hypochlorite

Dey; Ramanathan

Proceedings of the National Institute of Sciences of India, 1943 , vol. 9, p. 193,222 Full Text Show Details

Kay-Fries Chem.Inc.

Patent: US2413493 , 1941 ; Full Text Show Details

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Rx-ID: 638041 Find similar reactions

T=190°C; Erhitzen des Reaktionsprodukts mit wss.Schwefelsaeure auf 125grad;

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Magidson; Garkuscha

Zhurnal Obshchei Khimii, 1941 , vol. 11, p. 339,341 Chem.Abstr., 1941 , p. 5868 Full Text Show Details

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Rx-ID: 780071 Find similar reactions

T=180°C; Erhitzen des Reaktionsprodukts mit wss.Salzsaeure;

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Bobranskii; Drabik

Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1941 , vol. 14, p. 410,413 Chem.Abstr., 1942 , p. 2531 Full Text Show Details

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Multi-step reaction with 2 steps 1: sodium acetate 2: 190 °C / Erhitzen des Reaktionsprodukts mit wss.Schwefelsaeure auf 125grad View Scheme

Rx-ID: 22031215 Find similar reactions

Magidson; Garkuscha

Zhurnal Obshchei Khimii, 1941 , vol. 11, p. 339,341 Chem.Abstr., 1941 , p. 5868 Full Text Show Details

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Rx-ID: 5855901 Find similar reactions

With ethanol; platinum

Hydrogenation;

Temmler-Werke

Patent: DE767186 , 1937 ; DRP/DRBP Org.Chem. Full Text Show Details

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Rx-ID: 5855898 Find similar reactions

With ethanol; sulfuric acid; acetic acid

T=30 - 40°C; Reduktion an einer KupferKathode;

Alles

Journal of the American Chemical Society, 1932 , vol. 54, p. 271,273 Full Text Show Details

With ethanol; sulfuric acid; acetic acid

T=30 - 40°C; Reduktion an einer QuecksilberKathode;

Alles

Journal of the American Chemical Society, 1932 , vol. 54, p. 271,273 Full Text Show Details

Synthesize Find similar With ethanol; palladium

Hydrogenation;

Rx-ID: 5855900 Find similar reactions

Hartung; Munch

Journal of the American Chemical Society, 1931 , vol. 53, p. 1875,1878 Full Text Show Details

Synthesize Find similar With potassium hydroxide; bromine

Synthesize Find similar Edeleanu

Chemische Berichte, 1887 , vol. 20, p. 618 Full Text Show Details

Rx-ID: 413188 Find similar reactions