2-(5-Methoxy-1H-indol-3-yl)ethan-1-amine (5-Methoxytryptamine) by Asch

Reaxys

PubChem

eMolecules

Reactions (1179)

Substances (24)

Citations (747)

Structure

Structure/Compound Data Chemical Name: 5-methoxytryptamine Reaxys Registry Number: 145587

CAS Registry Number: 608-07-1 Type of Substance: heterocyclic Molecular Formula: C11H14N2O Linear Structure Formula: NH2CH2CH2(NC8H5)OCH3

Molecular Weight: 190.245

InChI Key: JTEJPPKMYBDEMY-UHFFFAOYSA-N

N° of preparations All Preps | All Reactions 45 prep out of 1031 reactions.

Synthesize | Hide Details Find similar Chemical Names and Synonyms 5-methoxytryptamine, 2-(5-methoxyindol-3-yl)ethylamine Identification Substance Label (61) Label

Reference

Haefelinger, Guenter; Nimtz, Manfred; Horstmann, Volker; Benz, Thomas

Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 1999 , vol. 54, # 3 p. 397 - 414 Title/Abstract Full Text View citing articles Show Details

Aubriot, Silvere; Nicolle, Edwige; Lattier, Mireille; Morel, Cecile; Cao, Wenhong; Daniel, Kiefer W.; Collins, Sheila; Leclerc, Gerard; Faure, Patrice

Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 2 p. 209 - 212 Title/Abstract Full Text View citing articles Show Details

Sun Yat-Sen University; Pi, Rongbiao; Yang, Xiaohong; Liu, Xingguo; Chen, Ziwei; Wang, Shengnan

Patent: CN105906608 A, 2016 ; Title/Abstract Full Text Show Details

Available Data

N° of ref.

Identification Physical Data (52) Spectra (91) Bioactivity (241) Other Data (6)

639

He, Ling; Li, Ju-Lian; Zhang, Jian-Jun; Su, Pu; Zheng, Shi-Long

Synthetic Communications, 2003 , vol. 33, # 5 p. 741 - 747 Title/Abstract Full Text View citing articles Show Details

Faulkner, Katherine C.; Hurley, Katherine A.; Weibel, Douglas B.

Bioorganic and Medicinal Chemistry Letters, 2016 , vol. 26, # 22 p. 5539 - 5544 Title/Abstract Full Text Show Details

Klochkov; Afanas'Eva; Bulychev, Yu. N.; Neganova; Shevtsova

Russian Chemical Bulletin, 2012 , vol. 61, # 2 p. 409 - 415 Title/Abstract Full Text View citing articles Show Details

Ionescu, Alexandra; Cornut, Damien; Soriano, Sebastien; Guissart, Celine; Van Antwerpen, Pierre; Jabin, Ivan

Tetrahedron Letters, 2013 , vol. 54, # 45 p. 6087 - 6089 Title/Abstract Full Text View citing articles Show Details

Sawant, Rajiv T.; Stevens, Marc Y.; Sköld, Christian; Odell, Luke R.

Organic Letters, 2016 , vol. 18, # 20 p. 5392 - 5395 Title/Abstract Full Text Show Details

Zhu, Yan-Ping; Liu, Mei-Cai; Cai, Qun; Jia, Feng-Cheng; Wu, An-Xin

Chemistry - A European Journal, 2013 , vol. 19, # 31 p. 10132 - 10137 Title/Abstract Full Text View citing articles Show Details

Shmatova, Olga I.; Khrustalev, Victor N.; Nenajdenko, Valentine G.

Organic Letters, 2016 , vol. 18, # 18 p. 4494 - 4497 Title/Abstract Full Text Show Details

Zhao, Fei; Dai, Jiang-Kun; Liu, Dan; Wang, Shi-Jun; Wang, Jun-Ru

Molecules, 2016 , vol. 21, # 3 art. no. 390 Title/Abstract Full Text View citing articles Show Details

Benchekroun, Mohamed; Romero, Alejandro; Egea, Javier; León, Rafael; Michalska, Patrycja; Buendía, Izaskun; Jimeno, María Luisa; Jun, Daniel; Janockova, Jana; Sepsova, Vendula; Soukup, Ondrej; Bautista-Aguilera, Oscar M.; Refouvelet, Bernard; Ouari, Olivier; Marco-Contelles, José; Ismaili, Lhassane

Journal of Medicinal Chemistry, 2016 , vol. 59, # 21 p. 9967 - 9973 Title/Abstract Full Text Show Details

Wang, Jin; Wang, Zhi-Min; Li, Xue-Mei; Li, Fan; Wu, Jia-Jia; Kong, Ling-Yi; Wang, Xiao-Bing

Bioorganic and Medicinal Chemistry, 2016 , vol. 24, # 18 p. 4324 - 4338 Title/Abstract Full Text View citing articles Show Details

11b

Yokoo, Hidetomo; Ohsaki, Ayumi; Kagechika, Hiroyuki; Hirano, Tomoya

Tetrahedron, 2016 , vol. 72, # 39 p. 5872 - 5879 Title/Abstract Full Text Show Details

14b

Zhao, Gaoyuan; Xie, Xingang; Sun, Haiyu; Yuan, Ziyun; Zhong, Zhuliang; Tang, Shouchu; She, Xuegong

Organic Letters, 2016 , vol. 18, # 10 p. 2447 - 2450 Title/Abstract Full Text View citing articles Show Details

5methoxytryptamine

NATIONAL HEALTH RESEARCH INSTITUTES; KUO, Cheng-Chin; WU, Kenneth Kun-Yu

Patent: WO2016/115188 A1, 2016 ; Title/Abstract Full Text Show Details

Chu, Lin; Lo, Jane-Ling; Yang, Yi-Tien; Cheng, Kang; Smith, Roy G.; Fisher, Michael H.; Wyvratt, Matthew J.; Goulet, Mark T.

Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 515 - 517 Title/Abstract Full Text View citing articles Show Details

Wu, Tom Y. H.; Schulte, Peter G.

Organic Letters, 2002 , vol. 4, # 23 p. 4033 - 4035 Title/Abstract Full Text View citing articles Show Details

Aziz, Jessy; Brion, Jean-Daniel; Hamze, Abdallah; Alami, Mouad

Advanced Synthesis and Catalysis, 2013 , vol. 355, # 11-12 p. 2417 - 2429 Title/Abstract Full Text View citing articles Show Details

Luo, Xiao-Ting; Wang, Chun-Ming; Liu, Yun; Huang, Zhen-Guang

European Journal of Medicinal Chemistry, 2015 , vol. 103, p. 302 - 311 Title/Abstract Full Text View citing articles Show Details

Sosi, Izidor; Anderluh, Marko; Sova, Matej; Gobec, Martina; Mlinari Raan, Irena; Derouaux, Adeline; Amoroso, Ana; Terrak, Mohammed; Breukink, Eefjan; Gobec, Stanislav

Journal of Medicinal Chemistry, 2015 , vol. 58, # 24 p. 9712 - 9721 Title/Abstract Full Text View citing articles Show Details

Mumford, Peter M.; Shiers, Jason J.; Tarver, Gary J.; Hayes, Jerome F.; Shipman, Michael

Tetrahedron Letters, 2008 , vol. 49, # 21 p. 3489 - 3491 Title/Abstract Full Text View citing articles Show Details

Li, Zeng; Li, Jing; Yang, Nan; Chen, Ying; Zhou, Yu; Ji, Xun; Zhang, Lei; Wang, Jinfang; Xie, Xin; Liu, Hong

Journal of Organic Chemistry, 2013 , vol. 78, # 21 p. 10802 - 10811 Title/Abstract Full Text View citing articles Show Details

Danda, Adithi; Kumar, Kamal; Waldmann, Herbert

Chemical Communications, 2015 , vol. 51, # 35 p. 7536 - 7539 Title/Abstract Full Text View citing articles Show Details

Bartolucci, Silvia; Mari, Michele; Bedini, Annalida; Piersanti, Giovanni; Spadoni, Gilberto

Journal of Organic Chemistry, 2015 , vol. 80, # 6 p. 3217 - 3222

Title/Abstract Full Text View citing articles Show Details

6a;33

Wang, Shengzheng; Fang, Kun; Dong, Guoqiang; Chen, Shuqiang; Liu, Na; Miao, Zhenyuan; Yao, Jianzhong; Li, Jian; Zhang, Wannian; Sheng, Chunquan

Journal of Medicinal Chemistry, 2015 , vol. 58, # 16 p. 6678 - 6696 Title/Abstract Full Text View citing articles Show Details

351

Oda, Shingo; Fujiwara, Ryoichi; Kutsuno, Yuki; Fukami, Tatsuki; Itoh, Tomoo; Yokoi, Tsuyoshi; Nakajima, Miki

Drug Metabolism and Disposition, 2015 , vol. 43, # 6 p. 812 - 818 Title/Abstract Full Text View citing articles Show Details

Prabhakar; Kumar, N. Vasanth; Reddy, M. Ravikanth; Sarma; Reddy, G. Om

Organic Process Research and Development, 1999 , vol. 3, # 3 p. 155 - 160 Title/Abstract Full Text View citing articles Show Details

Abd Razik, Basma M.; Osman, Hasnah; Basiri, Alireza; Salhin, Abdussalam; Kia, Yalda; Ezzat, Mohammed Oday; Murugaiyah, Vikneswaran

Bioorganic Chemistry, 2014 , vol. 57, p. 162 - 168 Title/Abstract Full Text View citing articles Show Details

Beasley, Benjamin O.; Alli-Balogun, Abimbola; Clarkson, Guy J.; Shipman, Michael

Tetrahedron Letters, 2014 , vol. 55, # 2 p. 541 - 543 Title/Abstract Full Text View citing articles Show Details

SI12

Nelson, Hosea M.; Reisberg, Solomon H.; Shunatona, Hunter P.; Patel, Jigar S.; Toste, F. Dean

Angewandte Chemie - International Edition, 2014 , vol. 53, # 22 p. 5600 - 5603 Angew. Chem., 2014 , vol. 126, # 22 p. 5706 - 5709,4 Title/Abstract Full Text View citing articles Show Details

Blough, Bruce E.; Landavazo, Antonio; Partilla, John S.; Decker, Ann M.; Page, Kevin M.; Baumann, Michael H.; Rothman, Richard B.

Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 19 p. 4754 - 4758 Title/Abstract Full Text View citing articles Show Details

Desroses, Matthieu; Koolmeister, Tobias; Jacques, Sylvain; Llona-Minguez, Sabin; Jacques-Cordonnier, Marie-Caroline; Cazares-Koerner, Armando; Helleday, Thomas; Scobie, Martin

Tetrahedron Letters, 2013 , vol. 54, # 27 p. 3554 - 3557 Title/Abstract Full Text View citing articles Show Details

21b

Mori, Mattia; Tintori, Cristina; Christopher, Robert Selwyne Arul; Radi, Marco; Schenone, Silvia; Musumeci, Francesca; Brullo, Chiara; Sanità, Patrizia; DelleMonache, Simona; Angelucci, Adriano; Kissova, Miroslava; Crespan, Emmanuele; Maga, Giovanni; Botta, Maurizio

ChemMedChem, 2013 , vol. 8, # 3 p. 484 - 496 Title/Abstract Full Text View citing articles Show Details

Show next 20

Hide facts

Label

Reference

Liu, Song; Scotti, John S.; Kozmin, Sergey A.

Journal of Organic Chemistry, 2013 , vol. 78, # 17 p. 8645 - 8654 Title/Abstract Full Text View citing articles Show Details

Adams, David; Benardeau, Agnes; Bickerdike, Mike J.; Bentley, Jon M.; Bissantz, Caterina; Bourson, Anne; Cliffe, Ian A.; Hebeisen, Paul; Kennett, Guy A.; Knight, Antony R.; Malcolm, Craig S.; Mizrahi, Jacques; Plancher, Jean-Marc; Richter, Hans; Roever, Stephan; Taylor, Sven; Vickers, Steven P.

Chimia, 2004 , vol. 58, # 9 p. 613 - 620 Title/Abstract Full Text View citing articles Show Details

Iskander, Magdy N.; Leung, Lok M.; Buley, Trevor; Ayad, Fadi; Di Iulio, Juliana; Tan, Yean Y.; Coupar, Ian M.

European Journal of Medicinal Chemistry, 2006 , vol. 41, # 1 p. 16 - 26 Title/Abstract Full Text View citing articles Show Details

Peshkov, Vsevolod A.; Pereshivko, Olga P.; Der Eycken, Erik V. Van

Advanced Synthesis and Catalysis, 2012 , vol. 354, # 14-15 p. 2841 - 2848 Title/Abstract Full Text View citing articles Show Details

Dong, Guoqiang; Wang, Shengzheng; Miao, Zhenyuan; Yao, Jianzhong; Zhang, Yongqiang; Guo, Zizhao; Zhang, Wannian; Sheng, Chunquan

Journal of Medicinal Chemistry, 2012 , vol. 55, # 17 p. 7593 - 7613 Title/Abstract Full Text View citing articles Show Details

Sanaboina, Chakrapani; Jana, Samaresh; Chidara, Sridhar; Patro, Balaram; Raolji, Gajendrasinh Balvantsinh; Eppakayala, Laxminarayana

Tetrahedron Letters, 2012 , vol. 53, # 37 p. 5027 - 5029,3 Title/Abstract Full Text Show Details

HERCULES TECHNOLOGY MANAGEMENT CO V, INC.; BLAGG, Julian

Patent: WO2011/47156 A1, 2011 ; Title/Abstract Full Text Show Details

5-MT

Bayari; Ide

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2003 , vol. 59, # 6 p. 1255 - 1263 Title/Abstract Full Text View citing articles Show Details

Ostrom, Rennolds S.; Ehlert, Frederick J.

Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 280, # 1 p. 189 - 199 Title/Abstract Full Text View citing articles Show Details

Sogawa; Tagawa; Fujino; Ohyama; Asanuma; Funada; Kitayama

Toxicology Letters, 2007 , vol. 170, # 1 p. 75 - 82 Title/Abstract Full Text View citing articles Show Details

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2008 , vol. 69, # 3 p. 748 - 756 Title/Abstract Full Text View citing articles Show Details

5-MeOT

Pan, Hui; Galligan, James J.

European Journal of Pharmacology, 1995 , vol. 278, # 1 p. 67 - 74 Title/Abstract Full Text View citing articles Show Details

Ramirez; Garcia-Garayoa; Romero; Monge; Roca; Del Rio; Lasheras

Journal of Pharmacy and Pharmacology, 1997 , vol. 49, # 1 p. 58 - 65 Title/Abstract Full Text View citing articles Show Details

Adham, Nika; Zgombick, John M.; Bard, Jonathan

Journal of Pharmacology and Experimental Therapeutics, 1998 , vol. 287, # 2 p. 508 - 514 Title/Abstract Full Text View citing articles Show Details

Leung; Walsh; Pulido-Rios; Eglen

British Journal of Pharmacology, 1996 , vol. 117, # 5 p. 926 - 930 Title/Abstract Full Text View citing articles Show Details

Leung; Blissard; Jett; Eglen

Naunyn-Schmiedeberg's Archives of Pharmacology, 1995 , vol. 351, # 6 p. 596 - 602 Title/Abstract Full Text View citing articles Show Details

Ge, Jian; Barnes, Nicholas M.

British Journal of Pharmacology, 1996 , vol. 117, # 7 p. 1475 - 1480 Title/Abstract Full Text View citing articles Show Details

El Mansari; Blier

British Journal of Pharmacology, 1996 , vol. 118, # 3 p. 681 - 689 Title/Abstract Full Text View citing articles Show Details

Ansanay; Sebben; Bockaert; Dumuis

European Journal of Pharmacology, 1996 , vol. 298, # 2 p. 165 - 174 Title/Abstract Full Text View citing articles Show Details

McLean, Peter G.; Coupar, Ian M.

European Journal of Pharmacology, 1996 , vol. 312, # 2 p. 215 - 225 Title/Abstract Full Text View citing articles Show Details

Hemedah; Coupar; Mitchelson

British journal of pharmacology, 1999 , vol. 126, # 1 p. 179 - 188 Title/Abstract Full Text View citing articles Show Details

Prins, Nicolaas H.; Briejer, Michel R.; Schuurkes, Jan A.J.

British Journal of Pharmacology, 1997 , vol. 120, # 4 p. 714 - 720 Title/Abstract Full Text View citing articles Show Details

Suzuki; Ohuchi; Asanuma; Kaneko; Yokomori; Ito; Isobe; Muramatsu

Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 1 p. 29 - 39 Title/Abstract Full Text View citing articles Show Details

Pauwels, Petrus J.; Colpaert, Francis C.

Biochemical Pharmacology, 1995 , vol. 50, # 10 p. 1651 - 1658 Title/Abstract Full Text View citing articles Show Details

Kloda, Anna; Adams, David J.

British Journal of Pharmacology, 2005 , vol. 144, # 3 p. 323 - 330 Title/Abstract Full Text View citing articles Show Details

Berg, Kelly A.; Maayani, Saul; Goldfarb, Joseph; Scaramellini, Clare; Leff, Paul; Clarke, William P.

Molecular Pharmacology, 1998 , vol. 54, # 1 p. 94 - 104 Title/Abstract Full Text View citing articles Show Details

Bower, Kiowa S.; Price, Kerry L.; Sturdee, Laura E.C.; Dayrell, Mariza; Dougherty, Dennis A.; Lummis, Sarah C.R.

European Journal of Pharmacology, 2008 , vol. 580, # 3 p. 291 - 297 Title/Abstract Full Text View citing articles Show Details

Celik, Leyla; Sinning, Steffen; Severinsen, Kasper; Hansen, Carsten G.; Moller, Maria S.; Bols, Mikael; Wiborg, Ove; Schiott, Birgit

Journal of the American Chemical Society, 2008 , vol. 130, # 12 p. 3853 - 3865 Title/Abstract Full Text View citing articles Show Details

Choo, Yeun-Mun; Hamann, Mark T.

Heterocycles, 2007 , vol. 71, # 2 p. 245 - 252 Title/Abstract Full Text View citing articles Show Details

5MT

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 66, # 1 p. 171 - 176 Title/Abstract Full Text View citing articles Show Details

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 - 941 Title/Abstract Full Text View citing articles Show Details

Trujillo, John I.; Meyers, Marvin J.; Anderson, David R.; Hegde, Shridhar; Mahoney, Matthew W.; Vernier, William F.; Buchler, Ingrid P.; Wu, Kun K.; Yang, Syaluan; Hartmann, Susan J.; Reitz, David B.

Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4657 - 4663 Title/Abstract Full Text View citing articles Show Details

IIb

Shestakov; Sidorenko; Shikhaliev; Pavlenko

Russian Journal of General Chemistry, 2007 , vol. 77, # 10 p. 1749 - 1760 Title/Abstract Full Text View citing articles Show Details

Somei, Masanori; Fukui, Yoshikazu; Hasegawa, Masakazu; Oshikiri, Naoki; Hayashi, Toshikatsu

Heterocycles, 2000 , vol. 53, # 8 p. 1725 - 1736 Title/Abstract Full Text View citing articles Show Details

Somei, Masanori; Iwaki, Takako; Yamada, Fumio; Tanaka, Yoshio; Shigenobu, Koki; Koike, Katsuo; Suzuki, Nobuo; Hattori, Atsuhiko

Heterocycles, 2006 , vol. 68, # 8 p. 1565 - 1569 Title/Abstract Full Text View citing articles Show Details

I-4b

Ates-Alagoz, Zeynep; Coban, Tulay; Buyukbingol, Erdem

Archiv der Pharmazie, 2006 , vol. 339, # 4 p. 193 - 200 Title/Abstract Full Text View citing articles Show Details

Van Tilburg, Erica W.; Windhorst, Albert D.; Van Der Mey, Margreet; Herscheid, Jacobus D. M.

Journal of Labelled Compounds and Radiopharmaceuticals, 2006 , vol. 49, # 4 p. 321 - 330 Title/Abstract Full Text View citing articles Show Details

III-4b

Gurkan, A. Selen; Karabay, Arzu; Buyukbingol, Zeliha; Adejare, Adeboye; Buyukbingol, Erdem

Archiv der Pharmazie, 2005 , vol. 338, # 2-3 p. 67 - 73 Title/Abstract Full Text View citing articles Show Details

12b

Soriano-Agaton, Flor; Lagoutte, Delphine; Poupon, Erwan; Roblot, Francois; Fournet, Alain; Gantier, Jean-Charles; Hocquemiller, Reynald

Journal of Natural Products, 2005 , vol. 68, # 11 p. 1581 - 1587 Title/Abstract Full Text View citing articles Show Details

275

SEQUELLA, INC.

Patent: WO2005/34857 A2, 2005 ; Title/Abstract Full Text Show Details

Jayaprakasam, Bolleddula; Strasburg, Gale A.; Nair, Muraleedharan G.

Tetrahedron, 2004 , vol. 60, # 13 p. 3109 - 3121 Title/Abstract Full Text View citing articles Show Details

BB3-F

Schreiber, Stuart L.; Stavenger, Robert A.; Mitchison, Timothy J.; Maliga, Zoltan

Patent: US2004/59138 A1, 2004 ; Title/Abstract Full Text Show Details

Thomson, Douglas W.; Commeureuc, Aurelien G. J.; Berlin, Stefan; Murphy, John A.

Synthetic Communications, 2003 , vol. 33, # 20 p. 3631 - 3641 Title/Abstract Full Text View citing articles Show Details

5, R = 5OCH3

Jiang, Weiqin; Zhang, Xuqing; Sui, Zhihua

Organic letters, 2003 , vol. 5, # 1 p. 43 - 46 Title/Abstract Full Text View citing articles Show Details

Karimi, Farhad; Langstroem, Bengt

European Journal of Organic Chemistry, 2003 , # 11 p. 2132 - 2137 Title/Abstract Full Text View citing articles Show Details

Mohanta, Pramod K.; Kim, Kyongtae

Tetrahedron Letters, 2002 , vol. 43, # 22 p. 3993 - 3996 Title/Abstract Full Text View citing articles Show Details

Substr., Tab.1, run 8

Connors, Richard V.; Zhang, Alex J.; Shuttleworth, Stephen J.

Tetrahedron Letters, 2002 , vol. 43, # 37 p. 6661 - 6663 Title/Abstract Full Text View citing articles Show Details

5-Me-OT

Zhang, Zhang-Jin; Trivedi, Bakula L.; De Paulis, Tomas; Schmidt, Dennis E.; Hewlett, William A.

Naunyn-Schmiedeberg's Archives of Pharmacology, 2002 , vol. 365, # 2 p. 123 - 132 Title/Abstract Full Text View citing articles Show Details

Revial, Gilbert; Jabin, Ivan; Lim, Sethy; Pfau, Michel

Journal of Organic Chemistry, 2002 , vol. 67, # 7 p. 2252 - 2256 Title/Abstract Full Text View citing articles Show Details

Amat; Seffar; Llor; Bosch

Synthesis, 2001 , # 2 p. 267 - 275 Title/Abstract Full Text View citing articles Show Details

Pouilhes, Annie; Duval-Lungulescu, Monica; Lambel, Stephanie; Leonce, Stephane; Langlois, Yves

Tetrahedron Letters, 2001 , vol. 42, # 47 p. 8297 - 8299 Title/Abstract Full Text View citing articles Show Details

5-MT, 1

Nakagawa, Hidehiko; Sumiki, Erika; Takusagawa, Mitsuko; Ikota, Nobuo; Matsushima, Yoshikazu; Ozawa, Toshihiko

Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 2 p. 261 - 265 Title/Abstract Full Text View citing articles Show Details

Tab.4., run 9, amine

Chung, In Hwa; Cha, Ki Suk; Seo, Jae Hong; Kim, Joong Hyup; Chung, Bong Young; Kim, Choong Sup

Heterocycles, 2000 , vol. 53, # 3 p. 529 - 533 Title/Abstract Full Text View citing articles Show Details

MTA

Wang, Hexiang; Ng, Tzi Bun

Pharmacology and Toxicology, 2000 , vol. 86, # 3 p. 125 - 128 Title/Abstract Full Text View citing articles Show Details

Lee; Rangisetty; Dukat; Slassi; Maclean; Glennon

Medicinal Chemistry Research, 2000 , vol. 10, # 4 p. 230 - 242 Title/Abstract Full Text View citing articles Show Details

9 (note 1)

Somei, Masanori; Oshikiri, Naoki; Hasegawa, Masakazu; Yamada, Fumio

Heterocycles, 1999 , vol. 51, # 6 p. 1237 - 1242 Title/Abstract Full Text View citing articles Show Details

Koike, Takeshi; Takeuchi, Naoki; Tobinaga, Seisho

Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 1 p. 128 - 130 Title/Abstract Full Text View citing articles Show Details

Merck 8607: 5HT

Sacco, Silvano; Aquilini, Luciano; Ghezzi, Pietro; Pinza, Mario; Guglielmotti, Angelo

European Journal of Pharmacology, 1998 , vol. 343, # 2-3 p. 249 - 255 Title/Abstract Full Text View citing articles Show Details

5-MeO-T

De Vries; Villalon; Heiligers; Saxena

Naunyn-Schmiedeberg's archives of pharmacology, 1997 , vol. 356, # 1 p. 90 - 99 Title/Abstract Full Text View citing articles Show Details

Merck 6083

Molinari; North; Dubocovich

European Journal of Pharmacology, 1996 , vol. 301, # 1-3 p. 159 - 168 Title/Abstract Full Text View citing articles Show Details

Merck: 9927

Pang; Tang; Song; Brown

Life Sciences, 1996 , vol. 58, # 13 p. 1047 - 1057 Title/Abstract Full Text View citing articles Show Details

mexamine

Dalpiaz, Alessandro; Borea, Pier Andrea; Gessi, Stefania; Gilli, Gastone

European Journal of Pharmacology, 1996 , vol. 312, # 1 p. 107 - 114 Title/Abstract Full Text View citing articles Show Details

Merck 6983

Carter; Champney; Hwang; Eglen

European Journal of Pharmacology, 1995 , vol. 280, # 3 p. 243 - 250 Title/Abstract Full Text View citing articles Show Details

5, 5-OMeT

Hong, Seoung-Soo; Dukat, Malgorzata; Teitler, Milt; Herrick-Davis, Kathy; McCallum, Kirk; et al.

Medicinal Chemistry Research, 1995 , vol. 5, # 9 p. 690 - 699 Title/Abstract Full Text Show Details

Patent-Specific Data (6) Prophetic Compound

Related Markush Structure (RN)

Location in Patent

Page/Page column

Bedos, Philippe; Baltas, Michel

Patent: US2015/31740 A1, 2015 ;

ELI LILLY AND COMPANY; Chen, Zhaogen; Cohen, Michael Philip; Fisher, Matthew Joseph; Gillig, James Ronald; McCowan, Jefferson Ray; Miller, Shawn Christopher; Schaus, John Mehnert; Giethlen, Bruno

Patent: EP1859798 B1, 2015 ;

29089273

Reference

Title/Abstract Full Text Show Details

23734867

NATREON, INC.; Ghosal, Shibnath; Veeraragavan, Muruganandam; Kalidindi, Sanyasi R.

Patent: US2013/115316 A1, 2013 ; Title/Abstract Full Text Show Details

22948333

CHEMILIA AB; HOeGBERG, Marita; DAHLSTEDT, Emma; SMITT, Olof; JOHANSSON, Tommy

Patent: WO2012/127032 A1, 2012 ; Title/Abstract Full Text Show Details

19816369

Aventis Pharma Limited

Patent: US6352977 B1, 2002 ; Title/Abstract Full Text Show Details

prophetic product

Eli Lilly and Company

Patent: US5096908 A1, 1992 ; Title/Abstract Full Text Show Details

Eli Lilly and Company

Patent: US5158956 A1, 1992 ; Title/Abstract Full Text Show Details

Derivative (27) Comment (Derivative)

Reference

Hydrochlorid: F:241-242grad

Suvorov et al.

Chemistry of Heterocyclic Compounds (New York, NY, United States), 1974 , vol. 10, p. 1316,1320 Khimiya Geterotsiklicheskikh Soedinenii, 1974 , vol. 10, p. 1496 Full Text Show Details

Picrat: F:216-217grad

Grandberg; Bobrova

Chemistry of Heterocyclic Compounds (New York, NY, United States), 1973 , vol. 9, p. 196,199 Khimiya Geterotsiklicheskikh Soedinenii, 1973 , vol. 9, p. 213 Full Text Show Details

Tartrat: F:166-167grad

Grandberg; Bobrova

Chemistry of Heterocyclic Compounds (New York, NY, United States), 1973 , vol. 9, p. 196,199 Khimiya Geterotsiklicheskikh Soedinenii, 1973 , vol. 9, p. 213 Full Text Show Details

Pikrat: F:212-213grad

Grandberg et al.

Doklady Chemistry, 1967 , vol. 176, p. 828 Doklady Akademii Nauk SSSR, 1967 , vol. 176, p. 583 Full Text Show Details

Salz m. 6-Hydroxy-5-methoxyindol-3-acetic acid C11H11NO4*C11H14N2O: B; P

Taborsky; Delvigs

Journal of Medicinal Chemistry, 1966 , vol. 9, p. 251,253 Full Text Show Details

Salz m. 6-Benzyloxy-5-methoxyindole-3-acetic Acid C18H17NO4*C11H14N2O: B; P

Taborsky; Delvigs

Journal of Medicinal Chemistry, 1966 , vol. 9, p. 251,253 Full Text Show Details

Pikrat: F:220grad (A., Zers.), braun

Tacconi

Farmaco, Edizione Scientifica, 1965 , vol. 20, p. 891,895,899 Full Text View citing articles Show Details

Hydrochlorid: C11H14N2O*HCl; IR-Sp. (KBr) von 2-16 μ

Taborski et al.

Journal of Medicinal Chemistry, 1965 , vol. 8, p. 460,465 Full Text Show Details

Acetat C11H14N2O*C2H4O2; F:141-143grad

Taborsky

Analytical Chemistry, 1964 , vol. 36, p. 1663 Full Text View citing articles Show Details

O...t C11H14N2O*C8H16O2; F:114-115grad

Taborsky

Analytical Chemistry, 1964 , vol. 36, p. 1663 Full Text View citing articles Show Details

Benzoat C11H14N2O*C7H6O2; F:160-161grad

Taborsky

Analytical Chemistry, 1964 , vol. 36, p. 1663 Full Text View citing articles Show Details

Mandelat C11H14N2O*C8H8O3; F:156-159grad

Taborsky

Analytical Chemistry, 1964 , vol. 36, p. 1663 Full Text View citing articles Show Details

Stearat C11H14N2O*C18H36O2; F:94-97grad

Taborsky

Analytical Chemistry, 1964 , vol. 36, p. 1663 Full Text View citing articles Show Details

Cyanacetat C11H14N2O*C3H3NO2; F:166.5-168grad

Taborsky

Analytical Chemistry, 1964 , vol. 36, p. 1663 Full Text View citing articles Show Details

Phenoxyacetat C11H14N2O*C8H9O3; F:173-176grad

Taborsky

Analytical Chemistry, 1964 , vol. 36, p. 1663 Full Text View citing articles Show Details

trans-Cinnamat C11H14N2O*C9H8O2; F:178-180grad

Taborsky

Analytical Chemistry, 1964 , vol. 36, p. 1663 Full Text View citing articles Show Details

Indol-3-ylacetat C11H14N2O*C10H9NO2; F:192-193grad

Taborsky

Analytical Chemistry, 1964 , vol. 36, p. 1663 Full Text View citing articles Show Details

Toluol-4-sulfonat C11H14N2O*C7H9O3S; F:183-187grad

Taborsky

Analytical Chemistry, 1964 , vol. 36, p. 1663 Full Text View citing articles Show Details

Salz m. Oxalsaeure: C11H14N2O*C2H2O4; F:170-171grad

Taborsky

Analytical Chemistry, 1964 , vol. 36, p. 1663 Full Text View citing articles Show Details

3-Nitro-salicylat C11H14N2O*C7H5NO5; F:202-203grad

Taborsky

Analytical Chemistry, 1964 , vol. 36, p. 1663 Full Text View citing articles Show Details

Hide facts Comment (Derivative)

Reference

4-Methoxy-phenylacetat C11H14N2O*C9H10O3; F:169-170grad

Taborsky

Analytical Chemistry, 1964 , vol. 36, p. 1663 Full Text View citing articles Show Details

5-Methoxy-indol-3-ylacetat C11H14N2O*C11H11NO3; F:181.5-183grad

Taborsky

Analytical Chemistry, 1964 , vol. 36, p. 1663 Full Text View citing articles Show Details

Pikrat: C11H14N2O*C6H3N3O7: F: 202-203grad; in A. ll., in W. wl.

Petrowa; Kawerina

J. Gen. Chem. USSR (Engl. Transl.), 1963 , vol. 33, p. 1333,1303 Full Text Show Details

Hydrochlorid C11H14N2O*HCl: Prep.: 1. 5-Hydroxy-tryptamin-hydrochlorid, A., Diazomethan, Ae. 2. HCl, A.; F: 239-240grad

Petrowa; Kawerina

J. Gen. Chem. USSR (Engl. Transl.), 1963 , vol. 33, p. 1333,1303 Full Text Show Details

Pikrat: C11H14N2O*C6H3N3O7: Prep.: 4-Methoxy-phenylhydrazin-hydrochlorid, 4-Amino-1,1-diethoxy-butan, wss. Essigsaeure (80grad, 2h); F: 219grad,aus A., Zers.

Keglevic et al.

Croatica Chemica Acta, 1961 , vol. 33, p. 83,86 Full Text Show Details

Hydrochlorid: C11H14N2O*HCl: F.: 249-250grad (Kofler), aus A.

Adlerova,E. et al.

Collection of Czechoslovak Chemical Communications, 1960 , vol. 25, p. 784 - 796 Full Text View citing articles Show Details

Sulfat: F.: 230-232grad (geschl. evac. Kapillare), aus aq. A.

May and Baker Ltd.

Patent: GB841524 , 1956 ; Chem.Abstr., 1962 , vol. 56, # 1431 Full Text Show Details

Physical Data Melting Point (21) Melting Point

Solvent (Melting Point)

Location

Reference

101 - 102 °C

Page/Page column 3

LES LABORATOIRES SERVIER

Patent: US2010/204276 A1, 2010 ; Title/Abstract Full Text Show Details

119 - 121 °C

benzene

He, Ling; Li, Ju-Lian; Zhang, Jian-Jun; Su, Pu; Zheng, Shi-Long

Synthetic Communications, 2003 , vol. 33, # 5 p. 741 - 747 Title/Abstract Full Text View citing articles Show Details

124 - 126 °C

Somei, Masanori; Oshikiri, Naoki; Hasegawa, Masakazu; Yamada, Fumio

Heterocycles, 1999 , vol. 51, # 6 p. 1237 - 1242 Title/Abstract Full Text View citing articles Show Details

121 - 123 °C

Wang, Alan P. L.; Li, Liang

Analytical Chemistry, 1992 , vol. 64, # 7 p. 769 - 775

Title/Abstract Full Text View citing articles Show Details

118 - 120 °C

Suvorov et al.

Chemistry of Heterocyclic Compounds (New York, NY, United States), 1974 , vol. 10, p. 1316,1320 Khimiya Geterotsiklicheskikh Soedinenii, 1974 , vol. 10, p. 1496 Full Text Show Details

Saito; Kikugawa

Journal of Heterocyclic Chemistry, 1979 , vol. 16, p. 1325,1327,1328 Full Text View citing articles Show Details

119 - 122 °C

Flaugh; Crowell; Clemens; Sawyer

Journal of Medicinal Chemistry, 1979 , vol. 22, # 1 p. 63 - 69 Title/Abstract Full Text View citing articles Show Details

122 °C

Buzas et al.

Synthesis, 1977 , p. 129 Full Text Show Details

120 - 121 °C

Richter Gedeon Vegyeszeti Gyar R.T.

Patent: FR2261271DE2344919 , 1973 ; Chem.Abstr., vol. 80, # 146016 Full Text Show Details

Szantay et al.

Synthesis, 1974 , p. 354 Full Text Show Details

118 - 119 °C

Grandberg; Bobrova

Chemistry of Heterocyclic Compounds (New York, NY, United States), 1973 , vol. 9, p. 196,199 Khimiya Geterotsiklicheskikh Soedinenii, 1973 , vol. 9, p. 213 Full Text Show Details

120 - 125.5 °C

Suvorov,N.N. et al.

Chemistry of Heterocyclic Compounds (New York, NY, United States), 1973 , vol. 9, p. 1361 - 1366 Khimiya Geterotsiklicheskikh Soedinenii, 1973 , vol. 9, p. 1505 - 1511 Full Text View citing articles Show Details

115 - 116 °C

Grandberg et al.

Doklady Chemistry, 1967 , vol. 176, p. 828 Doklady Akademii Nauk SSSR, 1967 , vol. 176, p. 583 Full Text Show Details

119.5 - 120.5 °C

Bertaccini; Vitali

Farmaco, Edizione Scientifica, 1967 , vol. 22, p. 229,231 Full Text Show Details

121.5 - 122.5 °C

Yajima et al.

Chemical and Pharmaceutical Bulletin, 1966 , vol. 14, p. 884,887 Full Text Show Details

119 °C

Julia; Manoury

Bulletin de la Societe Chimique de France, 1965 , p. 1411,1413 Full Text Show Details

Julia et al.

Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1960 , vol. 251, p. 394 Full Text Show Details

124 - 125 °C

petroleum ether

Takatori; Takashima

Yakugaku Zasshi, 1963 , vol. 83, p. 795,798 Full Text Show Details

119 - 120 °C

Adlerova,E. et al.

Collection of Czechoslovak Chemical Communications, 1960 , vol. 25, p. 784 - 796 Full Text View citing articles Show Details

Petrowa; Kawerina

J. Gen. Chem. USSR (Engl. Transl.), 1963 , vol. 33, p. 1333,1303 Full Text Show Details

215 - 217 °C

Mndzhoyan; Papayan

Izvestiya Akademii Nauk Armyanskoi SSR, Khimicheskie Nauki, 1961 , vol. 14, p. 603 Chem.Abstr., 1963 , vol. 58, # 4497c Full Text Show Details

117 - 119 °C

benzene

Kralt,T. et al.

Recueil des Travaux Chimiques des Pays-Bas, 1961 , vol. 80, p. 313 - 324 Full Text View citing articles Show Details

121.5 - 122.5 °C

benzene

Szmuszkovicz et al.

Journal of Organic Chemistry, 1960 , vol. 25, p. 857,858 Full Text Show Details

122 - 123 °C

Hoshino; Kobayashi

Justus Liebigs Annalen der Chemie, 1935 , vol. 516, p. 81,88 Justus Liebigs Annalen der Chemie, 1935 , vol. 520, p. 11,19 Full Text Show Details

Hide facts Melting Point

Solvent (Melting Point)

Reference

121 - 122 °C

diethyl ether

Wieland et al.

Justus Liebigs Annalen der Chemie, 1934 , vol. 513, p. 1,18 Full Text Show Details

Boiling Point (2) Boiling Point

Pressure (Boiling Point)

Reference

165 - 170 °C

0.08 Torr

Grandberg; Bobrova

Chemistry of Heterocyclic Compounds (New York, NY, United States), 1973 , vol. 9, p. 196,199 Khimiya Geterotsiklicheskikh Soedinenii, 1973 , vol. 9, p. 213 Full Text Show Details

165 - 170 °C

0.1 Torr

Grandberg et al.

Doklady Chemistry, 1967 , vol. 176, p. 828 Doklady Akademii Nauk SSSR, 1967 , vol. 176, p. 583 Full Text Show Details

Density (1) Density

Type (Density)

Reference

1.242 g·cm-3

crystallographic

Quarles et al.

Acta Crystallographica, 1974 , vol. 30, p. 95 Full Text Show Details

Association (MCS) (3) Description (Association (MCS))

Partner (Association (MCS))

Solvent (Association (MCS))

Comment (Association (MCS))

Formation constant of a complex

cetyltrimethylammonim bromide

H2O methanol

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2008 , vol. 69, # 3 p. 748 - 756 Title/Abstract Full Text View citing articles Show Details

Formation constant of a complex

sodium dodecyl-sulfate

H2O methanol

pH dependence

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2008 , vol. 69, # 3 p. 748 - 756 Title/Abstract Full Text View citing articles Show Details

Dipole moment of the complex

1,2-dichloro-ethane

Abu-Eittah; Abdou

Journal de Chimie Physique et de Physico-Chimie Biologique, 1996 , vol. 93, # 11-12 p. 1958 - 1973 Title/Abstract Full Text View citing articles Show Details

Reference

Chromatographic Data (1) Chromatographic data

Reference

HPLC (High performance liquid chromatography)

Prabhakar; Kumar, N. Vasanth; Reddy, M. Ravikanth; Sarma; Reddy, G. Om

Organic Process Research and Development, 1999 , vol. 3, # 3 p. 155 - 160 Title/Abstract Full Text View citing articles Show Details

Crystal Phase (3) Description (Crystal Phase)

Comment (Crystal Phase)

Reference

Crystal structure determination

β=98.7 grad, a=6.11 Angstroem, b=9.53 Angstroem, c=8.83 Angstroem, n=2.

Quarles et al.

Acta Crystallographica, 1974 , vol. 30, p. 95 Full Text Show Details

Crystal structure determination

Quarles et al.

Acta Crystallographica, 1974 , vol. 30, p. 95 Full Text Show Details

Solid state structure properties

Quarles et al.

Acta Crystallographica, Section B: Structural Crystallography and Crystal Chemistry, 1974 , vol. 30, p. 99,100, 101 Full Text Show Details

Crystal Property Description (2) Colour & Other Properties

Reference

colourless

Bartolucci, Silvia; Mari, Michele; Bedini, Annalida; Piersanti, Giovanni; Spadoni, Gilberto

Journal of Organic Chemistry, 2015 , vol. 80, # 6 p. 3217 - 3222 Title/Abstract Full Text View citing articles Show Details

light-yellow

He, Ling; Li, Ju-Lian; Zhang, Jian-Jun; Su, Pu; Zheng, Shi-Long

Synthetic Communications, 2003 , vol. 33, # 5 p. 741 - 747 Title/Abstract Full Text View citing articles Show Details

Crystal System (1) Crystal System

Reference

monoclinic

Quarles et al.

Acta Crystallographica, 1974 , vol. 30, p. 95 Full Text Show Details

Dissociation Exponent (3) Dissociation Exponent (pK)

Dissociation Group

Method (Dissociation Exponent)

Type (Dissociation Exponent)

Comment (Dissociation Exponent)

4.8

spectrophotometric

a1/apparent

Hela; Anipindi; Priyadarsini; O'Neill

Journal of Physical Chemistry B, 1999 , vol. 103, # 40 p. 8606 - 8611 Title/Abstract Full Text View citing articles Show Details

(pk')pK(b)

Julia; Lallemand

Bulletin de la Societe Chimique de France, 1973 , p. 2058,2059, 2061 Full Text Show Details

(pk')pK(a) (50percentig. wss. A.): 8.81

Grandberg et al.

Doklady Chemistry, 1967 , vol. 176, p. 828 Doklady Akademii Nauk SSSR, 1967 , vol. 176, p. 583 Full Text Show Details

Further Information (9) Description (Further Information)

Reference

Further information

Dimicoli; Helene

Biochemistry, 1974 , vol. 13, # 4 p. 714 - 723 Title/Abstract Full Text View citing articles Show Details

Further information

Agurell; Holmstedt; Lindgren; Schultes

Acta chemica Scandinavica, 1969 , vol. 23, # 3 p. 903 - 916 Title/Abstract Full Text View citing articles Show Details

Further information

Smaller et al.

Journal of Chemical Physics, 1967 , vol. 46, p. 3976,3979 Full Text Show Details

Further information

Taborsky; Delvigs

Journal of Medicinal Chemistry, 1966 , vol. 9, p. 251,253 Full Text Show Details

Further information

Taborski et al.

Journal of Medicinal Chemistry, 1965 , vol. 8, p. 460,465 Full Text Show Details

Reference

Further information

Taborsky

Analytical Chemistry, 1964 , vol. 36, p. 1663 Full Text View citing articles Show Details

Further information

Heinzelman; Szmuszkovicz

Progress in Drug Research, 1963 , vol. 6, p. 75,76-150 Chem.Abstr., 1964 , vol. 60, # 13215b Full Text Show Details

Further information

Petrowa; Kawerina

J. Gen. Chem. USSR (Engl. Transl.), 1963 , vol. 33, p. 1333,1303 Full Text Show Details

Further information

May and Baker Ltd.

Patent: GB841524 , 1956 ; Chem.Abstr., 1962 , vol. 56, # 1431 Full Text Show Details

Interatomic Distances and Angles (2) Description

Comment (Interatomic Distances and Angles)

Reference

Interatomic distances and angles

Roentgen-Diagramm.

Quarles et al.

Acta Crystallographica, 1974 , vol. 30, p. 95 Full Text Show Details

Interatomic distances and angles

Quarles et al.

Acta Crystallographica, Section B: Structural Crystallography and Crystal Chemistry, 1974 , vol. 30, p. 99,100, 101 Full Text Show Details

Liquid/Liquid Systems (MCS) (1) Description (Liquid/Liquid Systems (MCS))

Reference

Distribution between solvent 1 + 2

Kang; Green

Nature (London, United Kingdom), 1969 , vol. 222, p. 794 Full Text View citing articles Show Details

Partition octan-1-ol/water (MCS) (1) log POW

Reference

1.06

Faulkner, Katherine C.; Hurley, Katherine A.; Weibel, Douglas B.

Bioorganic and Medicinal Chemistry Letters, 2016 , vol. 26, # 22 p. 5539 - 5544 Title/Abstract Full Text Show Details

Space Group (1) Space Group

Reference

7 0

Quarles et al.

Acta Crystallographica, 1974 , vol. 30, p. 95 Full Text Show Details

Transport Phenomena (MCS) (1)

Description (Transport Phenomena (MCS))

Partner (Transport Phenomena (MCS))

Temperature (Transport Phenomena (MCS))

Diffusion

aq. sodium phosphate buffer

25 °C

Reference Robinson, David; Anderson, James E.; Lin, Jeong-long

Journal of Physical Chemistry, 1990 , vol. 94, # 2 p. 1003 1005 Title/Abstract Full Text View citing articles Show Details

Spectra NMR Spectroscopy (18) Description (NMR Spectroscopy)

Nucleus (NMR Spectroscopy)

Coupling Nuclei

Chemical shifts Spectrum

Solvents (NMR Spectroscopy)

Temperature (NMR Spectroscopy)

Frequency (NMR Spectroscopy)

Original Text (NMR Spectroscopy)

chloroform-d1

200 MHz

Location supporting information

Comment (NMR Spectroscopy)

Reference Bartolucci, Silvia; Mari, Michele; Bedini, Annalida; Piersanti, Giovanni; Spadoni,

Gilberto

Journal of Organic Chemistry, 2015 , vol. 80, # 6 p. 3217 - 3222 Title/Abstract Full Text View citing articles Show Details

chloroform-d1

NMR (CDC13): δ 10.58 (bs, 1H), 7.20 (t, J= 8.78 Hz; 1H), 7.07 (s, 1H), 6.98 (s, 1H), 6.71-6.68 (m, III), 3.75 (s, 3U), 2.81-2.69 (m, 4H), 1.39 (bs, 2H).

Page/Page column 40

Signals given

HERCULES TECHNOLOGY MANAGEMENT CO V, INC.; BLAGG, Julian

Patent: WO2011/47156 A1, 2011 ; Title/Abstract Full Text Show Details

Chemical shifts

CDCl3

200 MHz

He, Ling; Li, Ju-Lian; Zhang, Jian-Jun; Su, Pu; Zheng, Shi-Long

Synthetic Communications, 2003 , vol. 33, # 5 p. 741 - 747 Title/Abstract Full Text View citing articles Show Details

CDCl3

200 MHz

He, Ling; Li, Ju-Lian; Zhang, Jian-Jun; Su, Pu; Zheng, Shi-Long

Synthetic Communications, 2003 , vol. 33, # 5 p. 741 - 747 Title/Abstract Full Text View citing articles Show Details

Chemical shifts

13C

CDCl3

100.61 MHz

Thomson, Douglas W.; Commeureuc, Aurelien G. J.; Berlin, Stefan; Murphy, John A.

Synthetic Communications, 2003 , vol. 33, # 20 p. 3631 - 3641 Title/Abstract Full Text View citing articles Show Details

Chemical shifts

CDCl3

400 MHz

Thomson, Douglas W.; Commeureuc, Aurelien G. J.; Berlin, Stefan; Murphy, John A.

Synthetic Communications, 2003 , vol. 33, # 20 p. 3631 - 3641 Title/Abstract Full Text View citing articles Show Details

CDCl3

400 MHz

Thomson, Douglas W.; Commeureuc, Aurelien G. J.; Berlin, Stefan; Murphy, John A.

Synthetic Communications, 2003 , vol. 33, # 20 p. 3631 - 3641 Title/Abstract Full Text View citing articles Show Details

Spectrum

23.84 °C

300.133 MHz

Revial, Gilbert; Jabin, Ivan; Lim, Sethy; Pfau, Michel

Journal of Organic Chemistry, 2002 , vol. 67, # 7 p. 2252 - 2256 Title/Abstract Full Text View citing articles Show Details

Spectrum

13C

23.84 °C

75 MHz

Revial, Gilbert; Jabin, Ivan; Lim, Sethy; Pfau, Michel

Journal of Organic Chemistry, 2002 , vol. 67, # 7 p. 2252 - 2256 Title/Abstract Full Text View citing articles Show Details

Chemical shifts

13C

CDCl3

75 MHz

Revial, Gilbert; Jabin, Ivan; Lim, Sethy; Pfau, Michel

Journal of Organic Chemistry, 2002 , vol. 67, # 7 p. 2252 - 2256 Title/Abstract Full Text View citing articles Show Details

Chemical shifts

CDCl3

300 MHz

Revial, Gilbert; Jabin, Ivan; Lim, Sethy; Pfau, Michel

Journal of Organic Chemistry, 2002 , vol. 67, #

7 p. 2252 - 2256 Title/Abstract Full Text View citing articles Show Details

CDCl3

300 MHz

Revial, Gilbert; Jabin, Ivan; Lim, Sethy; Pfau, Michel

Journal of Organic Chemistry, 2002 , vol. 67, # 7 p. 2252 - 2256 Title/Abstract Full Text View citing articles Show Details

CDCl3

Somei, Masanori; Fukui, Yoshikazu; Hasegawa, Masakazu; Oshikiri, Naoki; Hayashi, Toshikatsu

Heterocycles, 2000 , vol. 53, # 8 p. 1725 - 1736 Title/Abstract Full Text View citing articles Show Details

Chemical shifts

CDCl3

Somei, Masanori; Fukui, Yoshikazu; Hasegawa, Masakazu; Oshikiri, Naoki; Hayashi, Toshikatsu

Heterocycles, 2000 , vol. 53, # 8 p. 1725 - 1736 Title/Abstract Full Text View citing articles Show Details

Chemical shifts

chloroform-d1

200 MHz

Prabhakar; Kumar, N. Vasanth; Reddy, M. Ravikanth; Sarma; Reddy, G. Om

Organic Process Research and Development, 1999 , vol. 3, # 3 p. 155 - 160 Title/Abstract Full Text View citing articles Show Details

Chemical shifts

Grin, L. M.; Khlaponina, L. N.; Pivnenko, N. S.; Selichenko, A. G.; Brutov, V. D.

Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 7 p. 476 - 479 Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 7 p. 819 - 822 Title/Abstract Full Text View citing articles Show Details

Chemical shifts

13C

CDCl3

40 °C

Alapishvili, M. G.; Popova, G. V.; Vorontsov, E. D.; Kireev, V. V.; Suvorov, N. N.

J. Gen. Chem. USSR (Engl. Transl.), 1983 , vol. 53, # 5 p. 1040 - 1044,919 - 923 Title/Abstract Full Text Show Details

NMR

Grandberg; Bobrova

Chemistry of Heterocyclic Compounds (New York, NY, United States), 1973 , vol. 9, p. 196,199 Khimiya Geterotsiklicheskikh Soedinenii, 1973 , vol. 9, p. 213 Full Text Show Details

Saito; Kikugawa

Journal of Heterocyclic Chemistry, 1979 , vol. 16, p. 1325,1327,1328 Full Text View citing articles Show Details

IR Spectroscopy (5) Description (IR Spectroscopy)

Solvent (IR Spectroscopy)

Reference

Bands

KBr

Somei, Masanori; Fukui, Yoshikazu; Hasegawa, Masakazu; Oshikiri, Naoki; Hayashi, Toshikatsu

Heterocycles, 2000 , vol. 53, # 8 p. 1725 - 1736 Title/Abstract Full Text View citing articles Show Details

Bayari; Ide

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2003 , vol. 59, # 6 p. 1255 - 1263 Title/Abstract Full Text View citing articles Show Details

Thomson, Douglas W.; Commeureuc, Aurelien G. J.; Berlin, Stefan; Murphy, John A.

Synthetic Communications, 2003 , vol. 33, # 20 p. 3631 - 3641 Title/Abstract Full Text View citing articles Show Details

Spectrum

KBr

Bayari; Ide

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2003 , vol. 59, # 6 p. 1255 - 1263 Title/Abstract Full Text View citing articles Show Details

Bands

CDCl3

Revial, Gilbert; Jabin, Ivan; Lim, Sethy; Pfau, Michel

Journal of Organic Chemistry, 2002 , vol. 67, # 7 p. 2252 - 2256 Title/Abstract Full Text View citing articles Show Details

Bands

Szmuszkovicz et al.

Journal of Organic Chemistry, 1960 , vol. 25, p. 857,858 Full Text Show Details

Prabhakar; Kumar, N. Vasanth; Reddy, M. Ravikanth; Sarma; Reddy, G. Om

Organic Process Research and Development, 1999 , vol. 3, # 3 p. 155 - 160 Title/Abstract Full Text View citing articles Show Details

Grandberg; Bobrova

Chemistry of Heterocyclic Compounds (New York, NY, United States), 1973 , vol. 9, p. 196,199 Khimiya Geterotsiklicheskikh Soedinenii, 1973 , vol. 9, p. 213 Full Text Show Details

Mass Spectrometry (6) Description (Mass Spectrometry)

Reference

electrospray ionisation (ESI) spectrum

Bartolucci, Silvia; Mari, Michele; Bedini, Annalida; Piersanti, Giovanni; Spadoni, Gilberto

Journal of Organic Chemistry, 2015 , vol. 80, # 6 p. 3217 - 3222 Title/Abstract Full Text View citing articles Show Details

spectrum electron impact (EI)

Gynther, Jukka; Peura, Pekka; Salmi, Seija

Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1985 , vol. 39, # 10 p. 849 - 860 Title/Abstract Full Text Show Details

Revial, Gilbert; Jabin, Ivan; Lim, Sethy; Pfau, Michel

Journal of Organic Chemistry, 2002 , vol. 67, # 7 p. 2252 - 2256 Title/Abstract Full Text View citing articles Show Details

spectrum

Wang, Alan P. L.; Li, Liang

Analytical Chemistry, 1992 , vol. 64, # 7 p. 769 - 775 Title/Abstract Full Text View citing articles Show Details

spectrum chemical ionization (CI)

Duarte, M. F. N.; Hutchinson, D. W.; Jennings, K. R.

Organic Mass Spectrometry, 1985 , vol. 20, # 7 p. 476 - 478 Title/Abstract Full Text Show Details

Gynther, Jukka; Peura, Pekka; Salmi, Seija

Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1985 , vol. 39, # 10 p. 849 - 860 Title/Abstract Full Text Show Details

negative ion spectroscopy

Duarte, M. F. N.; Hutchinson, D. W.; Jennings, K. R.

Organic Mass Spectrometry, 1985 , vol. 20, # 7 p. 476 - 478 Title/Abstract Full Text Show Details

Sergeev; Manusadzhyan

Chemistry of Heterocyclic Compounds (New York, NY, United States), 1973 , vol. 9, p. 1228 Khimiya Geterotsiklicheskikh Soedinenii, 1973 , vol. 9, p. 1357 Full Text Show Details

Wood et al.

Analytical Chemistry, 1976 , vol. 48, p. 981 Full Text View citing articles Show Details

Shaw; Wright; Milne

Biomedical mass spectrometry, 1977 , vol. 4, # 6 p. 348 - 353 Title/Abstract Full Text View citing articles Show Details

Agurell; Holmstedt; Lindgren; Schultes

Acta chemica Scandinavica, 1969 , vol. 23, # 3 p. 903 - 916 Title/Abstract Full Text View citing articles Show Details

UV/VIS Spectroscopy (41)

Solvent (UV/VIS Spectroscopy)

Absorption Maxima (UV/VIS)

Comment (UV/VIS Spectroscopy)

H2O

276.007 nm

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 66, # 1 p. 171 176 Title/Abstract Full Text View citing articles Show Details

ethane-1,2-diol

275.005 nm

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 66, # 1 p. 171 176 Title/Abstract Full Text View citing articles Show Details

methanol

275.005 nm

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 66, # 1 p. 171 176 Title/Abstract Full Text View citing articles Show Details

Reference

butan-1-ol

277.001 nm

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 66, # 1 p. 171 176 Title/Abstract Full Text View citing articles Show Details

propan-2-ol

277.001 nm

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 66, # 1 p. 171 176 Title/Abstract Full Text View citing articles Show Details

acetonitrile

276.007 nm

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 66, # 1 p. 171 176 Title/Abstract Full Text View citing articles Show Details

2-methyl-propan-2-ol

277.001 nm

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 66, # 1 p. 171 176 Title/Abstract Full Text View citing articles Show Details

dimethylformamide

279.002 nm

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 66, # 1 p. 171 176 Title/Abstract Full Text View citing articles Show Details

CH2Cl2

277.001 nm

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 66, # 1 p. 171 176 Title/Abstract Full Text View citing articles Show Details

ethyl acetate

277.001 nm

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 66, # 1 p. 171 176 Title/Abstract Full Text View citing articles Show Details

dioxane

272.005 nm

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 66, # 1 p. 171 176 Title/Abstract Full Text View citing articles Show Details

cyclohexane

276.007 nm

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 66, # 1 p. 171 176 Title/Abstract Full Text View citing articles Show Details

hexane

276.007 nm

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 66, # 1 p. 171 176 Title/Abstract Full Text View citing articles Show Details

aq. H2SO4

271 nm

Remark: Ho -3.0

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 941 Title/Abstract Full Text View citing articles Show Details

aq. H2SO4

274 nm 310 nm

Remark: Ho -2.0

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 941 Title/Abstract Full Text View citing articles Show Details

aq. H2SO4

274 nm 309 nm

Remark: Ho -1.0

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 941 Title/Abstract Full Text View citing articles Show Details

aq. H2SO4

273 nm 309 nm

Remark: pH 1.0 - 2.0

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 941 Title/Abstract Full Text View citing articles Show Details

aq. H2SO4

275 nm 309 nm

Remark: pH 4.0 - 5.0

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 941 Title/Abstract Full Text View citing articles Show Details

aq. NaOH

275 nm 309 nm

Remark: pH 8.0 - 9.5

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 -

aq. NaOH

Show next 20

276 nm 309 nm

941 Title/Abstract Full Text View citing articles Show Details

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 941 Title/Abstract Full Text View citing articles Show Details

Remark: pH 10.4

Hide facts

Description (UV/VIS Spectroscopy)

Solvent (UV/VIS Spectroscopy)

Absorption Maxima (UV/VIS)

Comment (UV/VIS Spectroscopy)

aq. NaOH

277 nm 309 nm

Remark: pH 11.3 - 12.0

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 - 941 Title/Abstract Full Text View citing articles Show Details

aq. NaOH

276 nm 327 nm

Remark: pH 13.0

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 - 941 Title/Abstract Full Text View citing articles Show Details

aq. NaOH

275 nm 327 nm

Remark: H- 14.0

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 - 941 Title/Abstract Full Text View citing articles Show Details

aq. NaOH

274 nm 326 nm

Remark: H- 14.7

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 - 941 Title/Abstract Full Text View citing articles Show Details

aq. NaOH

278 nm

Remark: H- 16.0

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 - 941 Title/Abstract Full Text View citing articles Show Details

aq. NaOH

280 nm

Remark: H- 17.0

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 - 941 Title/Abstract Full Text View citing articles Show Details

aq. NaOH

297 nm

Remark: H- 18.0

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 - 941 Title/Abstract Full Text View citing articles Show Details

various solvent(s)

273 nm 275 nm 310 nm

Remark: Ho 0.0

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 - 941 Title/Abstract Full Text View citing articles Show Details

various solvent(s)

272 nm 274 nm 310 nm

Remark: pH 1.1

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 - 941 Title/Abstract Full Text View citing articles Show Details

various solvent(s)

273 nm 310 nm

Remark: pH 2.1

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 - 941 Title/Abstract Full Text View citing articles Show Details

various solvent(s)

274 nm 310 nm

Remark: pH 3.3 - 4.2

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 - 941 Title/Abstract Full Text View citing articles Show Details

various solvent(s)

272 nm 310 nm

Remark: pH 4.9

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 - 941 Title/Abstract Full Text View citing articles Show Details

various solvent(s)

273 nm 310 nm

Remark: pH 7.0 - 9.0

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 - 941 Title/Abstract Full Text View citing articles Show Details

Reference

various solvent(s)

275 nm 310 nm

Remark: pH 10.0 -11.1

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 - 941 Title/Abstract Full Text View citing articles Show Details

various solvent(s)

274 nm

Remark: pH 2.2 - 11.0

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 - 941 Title/Abstract Full Text View citing articles Show Details

various solvent(s)

275 nm

Remark: pH 12.0

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 - 941 Title/Abstract Full Text View citing articles Show Details

various solvent(s)

275 nm 277 nm

Remark: pH 13.0

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 - 941 Title/Abstract Full Text View citing articles Show Details

various solvent(s)

278 nm

Remark: H- 13.9

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 - 941 Title/Abstract Full Text View citing articles Show Details

Spectrum

gaseous matrix

302.5 - 306.8 nm

Li, Liang; Lubman, David M.

Analytical Chemistry, 1988 , vol. 60, # 23 p. 2591 - 2598 Title/Abstract Full Text View citing articles Show Details

UV/VIS

Grandberg; Bobrova

Chemistry of Heterocyclic Compounds (New York, NY, United States), 1973 , vol. 9, p. 196,199 Khimiya Geterotsiklicheskikh Soedinenii, 1973 , vol. 9, p. 213 Full Text Show Details

Millie et al.

Journal of Medicinal Chemistry, 1968 , vol. 11, # 2 p. 207,209,210 Full Text View citing articles Show Details

Absorption maxima

Szmuszkovicz et al.

Journal of Organic Chemistry, 1960 , vol. 25, p. 857,858 Full Text Show Details

Taborsky; McIsaac

Journal of Medicinal Chemistry, 1964 , vol. 7, p. 135,140 Full Text Show Details

Fluorescence Spectroscopy (20) Description (Fluorescence Spectroscopy)

Solvent (Fluorescence Spectroscopy)

Fluorescence quenching

Comment (Fluorescence Spectroscopy)

Reference

Quenching with Br(1-)

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2008 , vol. 69, # 3 p. 748 - 756 Title/Abstract Full Text View citing articles Show Details

Maxima

micellar solution

concentration dependence. Object(s) of Study: pH dependence

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2008 , vol. 69, # 3 p. 748 - 756 Title/Abstract Full Text View citing articles Show Details

Spectrum

micellar solution

concentration dependence

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2008 , vol. 69, # 3 p. 748 - 756 Title/Abstract Full Text View citing articles Show Details

Maxima

H2O

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 66, # 1 p. 171 - 176 Title/Abstract Full Text View citing articles Show Details

Maxima

ethane-1,2-diol

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 66, # 1 p. 171 - 176 Title/Abstract Full Text View citing articles Show Details

Maxima

methanol

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 66, # 1 p. 171 - 176

Title/Abstract Full Text View citing articles Show Details

Maxima

butan-1-ol

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 66, # 1 p. 171 - 176 Title/Abstract Full Text View citing articles Show Details

Maxima

propan-2-ol

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 66, # 1 p. 171 - 176 Title/Abstract Full Text View citing articles Show Details

Maxima

acetonitrile

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 66, # 1 p. 171 - 176 Title/Abstract Full Text View citing articles Show Details

Maxima

2-methyl-propan-2-ol

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 66, # 1 p. 171 - 176 Title/Abstract Full Text View citing articles Show Details

Maxima

dimethylformamide

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 66, # 1 p. 171 - 176 Title/Abstract Full Text View citing articles Show Details

Maxima

CH2Cl2

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 66, # 1 p. 171 - 176 Title/Abstract Full Text View citing articles Show Details

Maxima

ethyl acetate

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 66, # 1 p. 171 - 176 Title/Abstract Full Text View citing articles Show Details

Maxima

dioxane

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 66, # 1 p. 171 - 176 Title/Abstract Full Text View citing articles Show Details

Maxima

cyclohexane

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 66, # 1 p. 171 - 176 Title/Abstract Full Text View citing articles Show Details

Maxima

hexane

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 66, # 1 p. 171 - 176 Title/Abstract Full Text View citing articles Show Details

Maxima

H2O

pH dependence

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 - 941 Title/Abstract Full Text View citing articles Show Details

Maxima

various solvent(s)

pH dependence

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 - 941 Title/Abstract Full Text View citing articles Show Details

Fluorescence intensity

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 - 941 Title/Abstract Full Text View citing articles Show Details

Fluorescence

Taborsky; McIsaac

Journal of Medicinal Chemistry, 1964 , vol. 7, p. 135,140 Full Text Show Details

Other Spectroscopic Methods (1) Description (Other Spectroscopic Methods)

Reference

Photoelectron spectrum

Domelsmith et al.

Journal of the American Chemical Society, 1977 , vol. 99, p. 4311,4315 Full Text Show Details

Bioactivity Pharmacological Data (239)

1 of 239

Comment (Pharmacological Data)

Bioactivities present

Reference

Adlerova,E. et al.

Collection of Czechoslovak Chemical Communications, 1960 , vol. 25, p. 784 - 796 Full Text View citing articles Show Details

Sandoz Ltd.

Patent: US4146643 A1, 1979 ; Title/Abstract Full Text Show Details

Suvorov,N.N. et al.

Nestec S. A.

Patent: US4506080 A1, 1985 ; Title/Abstract Full Text Show Details

Adir et Compagnie

Patent: US5276051 A1, 1994 ; Title/Abstract Full Text Show Details

Richter Gedeon Vegyeszeti Gyar Rt.

Patent: US4843080 A1, 1989 ; Title/Abstract Full Text Show Details

Flaugh; Crowell; Clemens; Sawyer

Journal of Medicinal Chemistry, 1979 , vol. 22, # 1 p. 63 - 69 Title/Abstract Full Text View citing articles Show Details

Lectec Corporation

Patent: US5776956 A1, 1998 ; Title/Abstract Full Text Show Details

Merck Sharp and Dohme Ltd.

Patent: US6187805 B1, 2001 ; Title/Abstract Full Text Show Details

Synaptic Pharmaceutical Corporation

Patent: US5476782 A1, 1995 ; Title/Abstract Full Text Show Details

Merck Patent Gesellschaft mit beschrankter Haftung

Patent: US5532241 A1, 1996 ; Title/Abstract Full Text Show Details

Cemaf; Laboratories Besins Iscovesco

Patent: US6048868 A1, 2000 ; Title/Abstract Full Text Show Details

CEMAF and Laboratoires Besins Iscovesco S.A.

Patent: US6004991 A1, 1999 ; Title/Abstract Full Text Show Details

Eli Lilly and Company

Patent: US5096908 A1, 1992 ; Title/Abstract Full Text Show Details

Fraschini; Franco; Di Bella; Luigi; Duranti; Ermanno

Patent: US5122535 A1, 1992 ; Title/Abstract Full Text Show Details

Eli Lilly and Company

Patent: US5158956 A1, 1992 ; Title/Abstract Full Text Show Details

Sibley, David R.; Monsma JR., Frederick J.; Hamblin, Mark

Patent: US2002/91235 A1, 2002 ; Title/Abstract Full Text Show Details

Kralt,T. et al.

Recueil des Travaux Chimiques des Pays-Bas, 1961 , vol. 80, p. 313 - 324 Full Text View citing articles Show Details

Synpatic Pharmaceutical Corporation

Patent: US2003/105318 A1, 2003 ; Title/Abstract Full Text Show Details

Synaptic Pharmaceutical Corporation

Patent: US2003/166066 A1, 2003 ; Title/Abstract Full Text Show Details

2 of 239

Comment (Pharmacological Data)

Bioactivities present

Reference

RICHTER GEDEON VEGYESZETI GYAR R.T.

Patent: EP202774 A3, 1989 ; Title/Abstract Full Text Show Details

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

Patent: WO1999/28456 A1, 1999 ; Title/Abstract Full Text Show Details

JANSSEN PHARMACEUTICA N.V.

Patent: WO2000/77199 A1, 2000 ; Title/Abstract Full Text Show Details

ASTRAZENECA AB

Patent: WO2001/85146 A1, 2001 ; Title/Abstract Full Text Show Details

FAUST PHARMACEUTICALS

Patent: WO2004/85392 A1, 2004 ; Title/Abstract Full Text Show Details

Board of Trustees of Michigan State University

Patent: US2005/59727 A1, 2005 ; Title/Abstract Full Text Show Details

The Board of Governors for Higher Education the State of Rhode Island and Providence Plantation.

Patent: US5863928 A1, 1999 ; Title/Abstract Full Text Show Details

BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY

Patent: WO2006/113557 A3, 2006 ; Title/Abstract Full Text Show Details

THE UNIVERSITY OF MONTANA

Patent: WO2008/24660 A2, 2008 ; Title/Abstract Full Text Show Details

GUILFORD, F., Timothy

Patent: WO2008/36979 A2, 2008 ; Title/Abstract Full Text Show Details

Velluz et al.

Bulletin de la Societe Chimique de France, 1958 , p. 673,676 Full Text View citing articles Show Details

Spaeth; Lederer

Chemische Berichte, 1930 , vol. 63, p. 2102,2106 Full Text View citing articles Show Details

Hoshino; Kobayashi

Justus Liebigs Annalen der Chemie, 1935 , vol. 516, p. 81,88 Justus Liebigs Annalen der Chemie, 1935 , vol. 520, p. 11,19 Full Text Show Details

Wieland et al.

Justus Liebigs Annalen der Chemie, 1934 , vol. 513, p. 1,18 Full Text Show Details

Velluz

Annales Pharmaceutiques Francaises, 1959 , vol. 17, p. 15,21 Full Text Show Details

Quadbeck; Roehm

Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1954 , vol. 297, p. 229,233 Full Text Show Details

Hoshino; Shimodaira

Bulletin of the Chemical Society of Japan, 1936 , vol. 11, p. 221,222 Full Text Show Details

Pietra

Farmaco, Edizione Scientifica, 1958 , vol. 13, p. 75,78 Full Text Show Details

Quarles et al.

Acta Crystallographica, 1974 , vol. 30, p. 95 Full Text Show Details

Wilkinson

Journal of the Chemical Society, 1958 , p. 2079 Full Text Show Details

3 of 239

Comment (Pharmacological Data)

Bioactivities present

Reference

Abramovitch; Shapiro

Journal of the Chemical Society, 1956 , p. 4589,4591 Full Text Show Details

Asero et al.

Justus Liebigs Annalen der Chemie, 1952 , vol. 576, p. 69,72, 73 Full Text Show Details

Matsushima

Chemical and pharmaceutical bulletin, 1968 , vol. 16, # 10 p. 2046 - 2055 Title/Abstract Full Text View citing articles Show Details

Muraseva et al.

Chemistry of Heterocyclic Compounds (New York, NY, United States), 1968 , vol. 4, p. 211 Khimiya Geterotsiklicheskikh Soedinenii, 1968 , vol. 4, p. 284 Full Text Show Details

Iskric; Kveder

Croatica Chemica Acta, 1965 , vol. 37, p. 233 Full Text Show Details

Julia; Manoury

Bulletin de la Societe Chimique de France, 1965 , p. 1411,1413 Full Text Show Details

Smaller et al.

Journal of Chemical Physics, 1967 , vol. 46, p. 3976,3979 Full Text Show Details

Julia et al.

Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1960 , vol. 251, p. 394 Full Text Show Details

Bowd et al.

Photochemistry and Photobiology, 1970 , vol. 11, p. 445,447 Full Text Show Details

Taborsky

Analytical Chemistry, 1964 , vol. 36, p. 1663 Full Text View citing articles Show Details

Heinzelman; Szmuszkovicz

Progress in Drug Research, 1963 , vol. 6, p. 75,76-150 Chem.Abstr., 1964 , vol. 60, # 13215b Full Text Show Details

Buzas et al.

Synthesis, 1977 , p. 129 Full Text Show Details

Sergeev; Manusadzhyan

Chemistry of Heterocyclic Compounds (New York, NY, United States), 1973 , vol. 9, p. 1228 Khimiya Geterotsiklicheskikh Soedinenii, 1973 , vol. 9, p. 1357 Full Text Show Details

Szmuszkovicz et al.

Journal of Organic Chemistry, 1960 , vol. 25, p. 857,858 Full Text Show Details

Taborski et al.

Journal of Medicinal Chemistry, 1965 , vol. 8, p. 460,465 Full Text Show Details

Wood et al.

Analytical Chemistry, 1976 , vol. 48, p. 981 Full Text View citing articles Show Details

Taborsky; Delvigs

Journal of Medicinal Chemistry, 1966 , vol. 9, p. 251,253 Full Text Show Details

Shaw; Wright; Milne

Biomedical mass spectrometry, 1977 , vol. 4, # 6 p. 348 - 353 Title/Abstract Full Text View citing articles Show Details

Bertaccini; Vitali

Farmaco, Edizione Scientifica, 1967 , vol. 22, p. 229,231 Full Text Show Details

Takatori; Takashima

Yakugaku Zasshi, 1963 , vol. 83, p. 795,798 Full Text Show Details

4 of 239

Comment (Pharmacological Data)

Bioactivities present

Reference

Ernest; Protiva

Collection of Czechoslovak Chemical Communications, 1961 , vol. 26, p. 1137,1140 Full Text Show Details

Sokolova; Magidson

Chemistry of Heterocyclic Compounds (New York, NY, United States), 1968 , vol. 4, p. 254 Khimiya Geterotsiklicheskikh Soedinenii, 1968 , vol. 4, p. 343 Full Text Show Details

Agurell; Holmstedt; Lindgren; Schultes

Acta chemica Scandinavica, 1969 , vol. 23, # 3 p. 903 - 916 Title/Abstract Full Text View citing articles Show Details

Taborsky; McIsaac

Journal of Medicinal Chemistry, 1964 , vol. 7, p. 135,140 Full Text Show Details

Grandberg et al.

Doklady Chemistry, 1967 , vol. 176, p. 828 Doklady Akademii Nauk SSSR, 1967 , vol. 176, p. 583 Full Text Show Details

Richter Gedeon Vegyeszeti Gyar R.T.

Patent: FR2261271DE2344919 , 1973 ; Chem.Abstr., vol. 80, # 146016 Full Text Show Details

Kang; Green

Nature (London, United Kingdom), 1969 , vol. 222, p. 794 Full Text View citing articles Show Details

Suvorov et al.

Chemistry of Heterocyclic Compounds (New York, NY, United States), 1974 , vol. 10, p. 1316,1320 Khimiya Geterotsiklicheskikh Soedinenii, 1974 , vol. 10, p. 1496 Full Text Show Details

Szantay et al.

Synthesis, 1974 , p. 354 Full Text Show Details

Macek; Vanecek

Collection of Czechoslovak Chemical Communications, 1961 , vol. 26, p. 2705,2718 Full Text Show Details

Domelsmith et al.

Journal of the American Chemical Society, 1977 , vol. 99, p. 4311,4315 Full Text Show Details

Grandberg; Bobrova

Chemistry of Heterocyclic Compounds (New York, NY, United States), 1973 , vol. 9, p. 196,199 Khimiya Geterotsiklicheskikh Soedinenii, 1973 , vol. 9, p. 213 Full Text Show Details

Mndzhoyan; Papayan

Izvestiya Akademii Nauk Armyanskoi SSR, Khimicheskie Nauki, 1961 , vol. 14, p. 603 Chem.Abstr., 1963 , vol. 58, # 4497c Full Text Show Details

Supniewski et al.

Dissertationes Pharmaceuticae, 1961 , vol. 13, p. 205,206-217 Chem.Abstr., 1962 , # 692 Full Text Show Details

Erspamer et al.

Journal of Pharmacy and Pharmacology, 1960 , vol. 12, p. 761,762 Full Text Show Details

Julia; Lallemand

Bulletin de la Societe Chimique de France, 1973 , p. 2058,2059, 2061 Full Text Show Details

Lab.francais de chimiotherapie

Patent: US2920080 , 1960 ; Chem.Abstr., 1960 , vol. 54, # 13019a Full Text Show Details

Quarles et al.

Acta Crystallographica, Section B: Structural Crystallography and Crystal Chemistry, 1974 , vol. 30, p. 99,100, 101 Full Text Show Details

Kametani et al.

Chemical and Pharmaceutical Bulletin, 1972 , vol. 20, p. 2057 Full Text Show Details

Dimicoli; Helene

Biochemistry, 1974 , vol. 13, # 4 p. 714 - 723 Title/Abstract Full Text View citing articles Show Details

5 of 239

Comment (Pharmacological Data)

Bioactivities present

Reference

Kobayashi et al.

Journal of Medicinal Chemistry, 1969 , vol. 12, # 4 p. 636 Full Text View citing articles Show Details

Keglevic et al.

Croatica Chemica Acta, 1961 , vol. 33, p. 83,86 Full Text Show Details

May and Baker Ltd.

Patent: GB841524 , 1956 ; Chem.Abstr., 1962 , vol. 56, # 1431 Full Text Show Details

Yajima et al.

Chemical and Pharmaceutical Bulletin, 1966 , vol. 14, p. 884,887 Full Text Show Details

Petrowa; Kawerina

J. Gen. Chem. USSR (Engl. Transl.), 1963 , vol. 33, p. 1333,1303 Full Text Show Details

Tacconi

Farmaco, Edizione Scientifica, 1965 , vol. 20, p. 891,895,899 Full Text View citing articles Show Details

Millie et al.

Journal of Medicinal Chemistry, 1968 , vol. 11, # 2 p. 207,209,210 Full Text View citing articles Show Details

Saito; Kikugawa

Journal of Heterocyclic Chemistry, 1979 , vol. 16, p. 1325,1327,1328 Full Text View citing articles Show Details

Robinson, David; Anderson, James E.; Lin, Jeong-long

Journal of Physical Chemistry, 1990 , vol. 94, # 2 p. 1003 - 1005 Title/Abstract Full Text View citing articles Show Details

Hoelscher, Peter; Knoelker, Hans-Joachim; Winterfeldt, Ekkehard

Tetrahedron Letters, 1990 , vol. 31, # 19 p. 2705 - 2706 Title/Abstract Full Text View citing articles Show Details

Kobayashi; Cheng; Ohta; Nozoe; Ohizumi; Sasaki

Journal of Organic Chemistry, 1990 , vol. 55, # 11 p. 3666 - 3670 Title/Abstract Full Text View citing articles Show Details

Glennon, Richard A.; Chaurasia, Chandra; Titeler, Milt

Journal of Medicinal Chemistry, 1990 , vol. 33, # 10 p. 2777 - 2784

Title/Abstract Full Text View citing articles Show Details

Laronze, Jean-Yves; Gauvin-Hussenet, Christine; Levy, Jean

Tetrahedron Letters, 1991 , vol. 32, # 5 p. 619 - 622 Title/Abstract Full Text View citing articles Show Details

Wasserman, Harry H.; Kelly, Terence A.

Tetrahedron Letters, 1989 , vol. 30, # 50 p. 7117 - 7120 Title/Abstract Full Text View citing articles Show Details

Bobowski; Shavel Jr.

Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 6 p. 1679 - 1688 Title/Abstract Full Text View citing articles Show Details

Bobowski, George

Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 1179 - 1187 Title/Abstract Full Text Show Details

Bobowski, George

Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 267 - 272 Title/Abstract Full Text Show Details

Hudlicky, Tomas; Kutchan, Toni M.; Shen, Grace; Sutliff, Vincent E.; Coscia, Carmine J.

Journal of Organic Chemistry, 1981 , vol. 46, # 8 p. 1738 - 1741 Title/Abstract Full Text View citing articles Show Details

Vercauteren, Joseph; Lavaud, Catherine; Levy, Jean; Massiot, Georges

Journal of Organic Chemistry, 1984 , vol. 49, # 12 p. 2278 - 2279 Title/Abstract Full Text View citing articles Show Details

Wang, Alan P. L.; Li, Liang

Analytical Chemistry, 1992 , vol. 64, # 7 p. 769 - 775 Title/Abstract Full Text View citing articles Show Details

6 of 239

Comment (Pharmacological Data)

Bioactivities present

Reference

Massiot, Georges; Levy, Jean

Bulletin de la Societe Chimique de France, 1981 , vol. 2, # 11-12 p. 463 - 467 Title/Abstract Full Text Show Details

Krause; Halls; Karavolas

Steroids, 1980 , vol. 36, # 3 p. 305 - 320 Title/Abstract Full Text View citing articles Show Details

Elliott, Arthur J.; Gold, Elijah H.; Guzik, Henry

Journal of Medicinal Chemistry, 1980 , vol. 23, # 11 p. 1268 - 1269 Title/Abstract Full Text View citing articles Show Details

Bergman, Jan; Bergman, Solveig

Journal of Organic Chemistry, 1985 , vol. 50, # 8 p. 1246 - 1255 Title/Abstract Full Text View citing articles Show Details

Burov, Yu. V.; Zagorevskii, V. A.; Zhukov, V. N.; Novikova, N. N.; Silenko, I. D.

Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 8 p. 559 - 563 Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 8 p. 936 - 940 Title/Abstract Full Text View citing articles Show Details

Partsvaniya, D. A.; Akhvlediani, R. N.; Gordeev, E. N.; Vigdorchik, M. M.; Kuleshova, L. N.; et al.

Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 12 p. 833 - 838 Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 12 p. 1454 - 1459 Title/Abstract Full Text View citing articles Show Details

Mizrakh, L. I.; Polonskaya, L. Yu.; Gvozdetskii, A. N.; Vasil'ev, A. M.; Ivanova, T. M.; Lisina, N. I.

Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 3 p. 210 - 217 Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 3 p. 322 - 328 Title/Abstract Full Text View citing articles Show Details

Grin, L. M.; Khlaponina, L. N.; Pivnenko, N. S.; Selichenko, A. G.; Brutov, V. D.

Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 7 p. 476 - 479 Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 7 p. 819 - 822 Title/Abstract Full Text View citing articles Show Details

Yous; Andrieux; Howell; Morgan; Renard; Pfeiffer; Lesieur; Guardiola-Lemaitre

Journal of Medicinal Chemistry, 1992 , vol. 35, # 8 p. 1484 - 1486 Title/Abstract Full Text View citing articles Show Details

Macor; Fox; Johnson; Koe; Lebel; Zorn

Journal of Medicinal Chemistry, 1992 , vol. 35, # 20 p. 3625 - 3632 Title/Abstract Full Text View citing articles Show Details

Hibert; McDermott; Middlemiss; Mir; Fozard

European Journal of Medicinal Chemistry, 1989 , vol. 24, # 1 p. 31 - 37 Title/Abstract Full Text View citing articles Show Details

Li, Liang; Lubman, David M.

Analytical Chemistry, 1988 , vol. 60, # 23 p. 2591 - 2598 Title/Abstract Full Text View citing articles Show Details

Repke, David B.; Grotjahn, Douglas B.; Shulgin, Alexander T.

Journal of Medicinal Chemistry, 1985 , vol. 28, # 7 p. 892 - 896 Title/Abstract Full Text View citing articles Show Details

Ivanova, E. V.; Popova, G. V.; Suvorov, N. N.

Journal of Organic Chemistry USSR (English Translation), 1992 , vol. 28, # 3.1 p. 385 - 390 Zhurnal Organicheskoi Khimii, 1992 , vol. 28, # 3 p. 474 - 481 Title/Abstract Full Text Show Details

Strobl; Von Kruedener; Stockigt; Guengerich; Wolff

Journal of Medicinal Chemistry, 1993 , vol. 36, # 9 p. 1136 - 1145 Title/Abstract Full Text View citing articles Show Details

Dijkstra, Gerard D. H.; Tulp, Martin Th. M.; Hermkens, Pedro H. H.; Maarseveen, Jan H. van; Scheeren, Hans W.; Kruse, Chris G.

Recueil des Travaux Chimiques des Pays-Bas, 1993 , vol. 112, # 2 p. 131 - 136 Title/Abstract Full Text View citing articles Show Details

Duarte, M. F. N.; Hutchinson, D. W.; Jennings, K. R.

Organic Mass Spectrometry, 1985 , vol. 20, # 7 p. 476 - 478 Title/Abstract Full Text Show Details

Gynther, Jukka; Peura, Pekka; Salmi, Seija

Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1985 , vol. 39, # 10 p. 849 - 860 Title/Abstract Full Text Show Details

Suvorov, N. N.; Popova, G. V.; Neklyudov, A. D.; Tsvetkov, E. V.; Turchin, K. F.; et al.

J. Gen. Chem. USSR (Engl. Transl.), 1982 , vol. 52, # 10 p. 2337 - 2342,2079 - 2083 Title/Abstract Full Text Show Details

Hoelscher, Peter; Knoelker, Hans-Joachim; Winterfeldt, Ekkehard

Israel Journal of Chemistry, 1991 , vol. 31, # 3 p. 187 - 194 Title/Abstract Full Text Show Details

7 of 239

8 of 239

Comment (Pharmacological Data)

Bioactivities present

Reference

Maki, Yasuo; Kimoto, Hiroshi; Fujii, Shozo; Nishida, Masakazu; Cohen, Louis A.

Journal of Fluorine Chemistry, 1989 , vol. 43, p. 189 - 206 Title/Abstract Full Text View citing articles Show Details

Nichols; Lloyd; Johnson; Hoffman

Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1406 - 1412 Title/Abstract Full Text View citing articles Show Details

Glennon; Titeler; Lyon; Slusher

Journal of Medicinal Chemistry, 1988 , vol. 31, # 4 p. 867 - 870 Title/Abstract Full Text View citing articles Show Details

Glennon, Richard A.; Naiman, Noreen A.; Pierson, M. Edward; Smith, J. Doyle; Ismaiel, Abd M.; et al.

Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1921 - 1926 Title/Abstract Full Text View citing articles Show Details

Blickenstaff; Brandstadter; Reddy; Witt

Journal of Pharmaceutical Sciences, 1994 , vol. 83, # 2 p. 216 - 218 Title/Abstract Full Text View citing articles Show Details

Wilkins, David J.; Jackson, Anthony H.; Shannon, Patrick V. R.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 3 p. 299 - 308 Title/Abstract Full Text View citing articles Show Details

Spadoni; Stankov; Duranti; Biella; Lucini; Salvatori; Fraschini

Journal of Medicinal Chemistry, 1993 , vol. 36, # 25 p. 4069 - 4074 Title/Abstract Full Text View citing articles Show Details

Balsamini; Spadoni; Duranti; Cerrini; Lamba; Fedeli

Farmaco, 1989 , vol. 44, # 4 p. 399 - 413 Title/Abstract Full Text View citing articles Show Details

Alapishvili, M. G.; Popova, G. V.; Vorontsov, E. D.; Kireev, V. V.; Suvorov, N. N.

J. Gen. Chem. USSR (Engl. Transl.), 1983 , vol. 53, # 5 p. 1040 - 1044,919 - 923 Title/Abstract Full Text Show Details

Guengoer, Timur; Malabre, Patrice; Teulon, J.M.

Synthetic Communications, 1994 , vol. 24, # 16 p. 2247 - 2256 Title/Abstract Full Text Show Details

Corcuera, Luis J.

Phytochemistry (Elsevier), 1984 , vol. 23, # 3 p. 539 - 542 Title/Abstract Full Text View citing articles Show Details

Petrunin, I. A.; Vinograd, L. Kh.; Przhiyalgovskaya, N. M.; Suvorov, N. N.

Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987 , vol. 23, # 8 p. 839 - 842 Khimiya Geterotsiklicheskikh Soedinenii, 1987 , # 8 p. 1050 - 1053 Title/Abstract Full Text View citing articles Show Details

Glennon; Dukat; El-Bermawy; Law; De los Angeles; Teitler; King; Herrick-Davis

Journal of Medicinal Chemistry, 1994 , vol. 37, # 13 p. 1929 - 1935 Title/Abstract Full Text View citing articles Show Details

Jackson, Anthony; Shannon, Patrick V. R.; Wilkins, David J.

Journal of the Chemical Society, Chemical Communications, 1987 , # 9 p. 653 - 654 Title/Abstract Full Text View citing articles Show Details

Kon-Ya, Kazumi; Shimidzu, Nobuyoshi; Miki, Wataru; Endo, Mamoru

Bioscience, Biotechnology, and Biochemistry, 1994 , vol. 58, # 12 p. 2178 - 2181 Title/Abstract Full Text Show Details

Pellegrini; Strassler; Weber; Borschberg

Tetrahedron Asymmetry, 1994 , vol. 5, # 10 p. 1979 - 1992 Title/Abstract Full Text View citing articles Show Details

Suvorova, E. V.; Popova, G. V.; Suvorov, N. N.

Russian Journal of General Chemistry, 1993 , vol. 63, # 9.2 p. 1480 - 1483 Zhurnal Obshchei Khimii, 1993 , vol. 63, # 9 p. 2126 - 2130 Title/Abstract Full Text Show Details

Mokrosz, M.J.; Paluchowska, M.H.; Misztal, S.

Polish Journal of Chemistry, 1995 , vol. 69, # 2 p. 264 - 268 Title/Abstract Full Text Show Details

Bascop, Sophie-Isabelle; Sapi, Janos; Laronze, Jean-Yves; Levy, Jean

Heterocycles, 1994 , vol. 38, # 4 p. 725 - 732 Title/Abstract Full Text View citing articles Show Details

Hardcastle

Journal of Pharmacy and Pharmacology, 1995 , vol. 47, # 9 p. 744 - 749 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

Bioactivities present

Reference

Garaeva, L. D.; Goryunova, O. V.; Yartseva, I. V.; Mashalova, N. A.; Melnik, S. Ya.

Russian Journal of Bioorganic Chemistry, 1995 , vol. 21, # 9 p. 619 - 625 Bioorganicheskaya Khimiya, 1995 , vol. 21, # 9 p. 717 - 723 Title/Abstract Full Text Show Details

Gaillard, Patrick; Carrupt, Pierre-Alain; Testa, Bernard; Schambel, Philippe

Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 126 - 134 Title/Abstract Full Text View citing articles Show Details

Lasheras, Berta; Berjon, Angel; Montanes, Rafael; Roca, Joan; Romero, Gonzalo; Ramirez, Maria J.; Del Rio, Joaquin

Arzneimittel-Forschung/Drug Research, 1996 , vol. 46, # 4 p. 401 - 406 Title/Abstract Full Text View citing articles Show Details

Glennon, Richard A.; Hong, Seoung-Soo; Bondarev, Mikhail; Law, Ho; Dukat, Malgorzata; Rakhit, Suman; Power, Patricia; Fan, Ermei; Kinneau, Diana; Kamboj, Rajender; Teitler, Milt; Herrick-Davis, Katharine; Smith, Carol

Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 314 - 322 Title/Abstract Full Text View citing articles Show Details

Kurihara, Takushi; Sakamoto, Yasuhiko; Kimura, Tetsuya; Ohishi, Hirofumi; Harusawa, Shinya; Yoneda, Ryuji; Suzutani, Tatsuo; Azuma, Masanobu

Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 5 p. 900 - 908 Title/Abstract Full Text View citing articles Show Details

Chu, Lin; Fisher, Michael H.; Goulet, Mark T.; Wyvratt, Matthew J.

Tetrahedron Letters, 1997 , vol. 38, # 22 p. 3871 - 3874 Title/Abstract Full Text View citing articles Show Details

Abu-Eittah; Abdou

Journal de Chimie Physique et de Physico-Chimie Biologique, 1996 , vol. 93, # 11-12 p. 1958 - 1973 Title/Abstract Full Text View citing articles Show Details

Vera; Tijmes; Valladares

Steroids, 1997 , vol. 62, # 2 p. 226 - 229 Title/Abstract Full Text View citing articles Show Details

Yu, Qian-Sheng; Pei, Xue-Feng; Holloway, Harold W.; Greig, Nigel H.; Brossi, Arnold

Journal of Medicinal Chemistry, 1997 , vol. 40, # 18 p. 2895 - 2901 Title/Abstract Full Text View citing articles Show Details

Pacofsky, Gregory J.; Lackey, Karen; Alligood, Krystal J.; Berman, Judd; Charifson, Paul S.; Crosby, Renae M.; Dorsey Jr., George F.; Feldman, Paul L.; Gilmer, Tona M.; Hummel, Conrad W.; Jordan, Steven R.; Mohr, Christopher; Shewchuk, Lisa M.; Sternbach, Daniel D.; Rodriguez, Marc

Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1894 - 1908 Title/Abstract Full Text View citing articles Show Details

Lin, Pen-Yuan; Shi, Sheng-Jie; Hsu, Feng-Lin; Chen, Chieh-Fu

Journal of the Chinese Chemical Society, 1998 , vol. 45, # 2 p. 323 - 326 Title/Abstract Full Text View citing articles Show Details

Barf, Tjeerd; Wikstroem, Hakan; Pauwels, Petrus J.; Palmier, Christiane; Tardif, Stephanie; Lundmark, Max; Sundell, Staffan

Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 9 p. 1469 - 1479 Title/Abstract Full Text View citing articles Show Details

Suzuki, Takeshi; Imanishi, Naoki; Itahana, Hirotsune; Watanuki, Susumu; Miyata, Keiji; Ohta, Mitsuaki; Nakahara, Hideaki; Yamagiwa, Yoko; Mase, Toshiyasu

Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 7 p. 1116 - 1124 Title/Abstract Full Text View citing articles Show Details

Carter; Champney; Hwang; Eglen

European Journal of Pharmacology, 1995 , vol. 280, # 3 p. 243 - 250 Title/Abstract Full Text View citing articles Show Details

Henin; Noe; Laronze; Pfeiffer; Renard; Guardiola-Lemaitre; Delagrange

Pharmaceutical Sciences, 1997 , vol. 3, # 5-6 p. 289 - 290 Title/Abstract Full Text View citing articles Show Details

Pan, Hui; Galligan, James J.

European Journal of Pharmacology, 1995 , vol. 278, # 1 p. 67 - 74 Title/Abstract Full Text View citing articles Show Details

Hong, Seoung-Soo; Dukat, Malgorzata; Teitler, Milt; Herrick-Davis, Kathy; McCallum, Kirk; et al.

Medicinal Chemistry Research, 1995 , vol. 5, # 9 p. 690 - 699 Title/Abstract Full Text Show Details

Ramirez; Garcia-Garayoa; Romero; Monge; Roca; Del Rio; Lasheras

Journal of Pharmacy and Pharmacology, 1997 , vol. 49, # 1 p. 58 - 65 Title/Abstract Full Text View citing articles Show Details

Hardcastle

Journal of Pharmacy and Pharmacology, 1997 , vol. 49, # 11 p. 1114 - 1120 Title/Abstract Full Text View citing articles Show Details

Hardcastle

Journal of Pharmacy and Pharmacology, 1998 , vol. 50, # 5 p. 539 - 547 Title/Abstract Full Text View citing articles Show Details

9 of 239

Comment (Pharmacological Data)

Bioactivities present

Reference

Vacher, Bernard; Bonnaud, Bernard; Funes, Philippe; Jubault, Nathalie; Koek, Wouter; Assie, Marie-Bernadette; Cosi, Cristina

Journal of Medicinal Chemistry, 1998 , vol. 41, # 25 p. 5070 - 5083 Title/Abstract Full Text View citing articles Show Details

Charlet-Fagnere, Catherine; Jiang, Wei-Qun; Laronze, Jean-Yves

Tetrahedron Letters, 1999 , vol. 40, # 9 p. 1685 - 1688 Title/Abstract Full Text View citing articles Show Details

Somei, Masanori; Oshikiri, Naoki; Hasegawa, Masakazu; Yamada, Fumio

Heterocycles, 1999 , vol. 51, # 6 p. 1237 - 1242 Title/Abstract Full Text View citing articles Show Details

Adham, Nika; Zgombick, John M.; Bard, Jonathan

Journal of Pharmacology and Experimental Therapeutics, 1998 , vol. 287, # 2 p. 508 - 514 Title/Abstract Full Text View citing articles Show Details

Hewlett, William A.; Trivedi, Bakula L.; Zhang, Zhang-Jin; De Paulis, Tomas; Schmidt, Dennis E.; Lovinger, David M.; Ansari, M. Sib; Ebert, Michael H.

Journal of Pharmacology and Experimental Therapeutics, 1999 , vol. 288, # 1 p. 221 - 231 Title/Abstract Full Text View citing articles Show Details

Koike, Takeshi; Takeuchi, Naoki; Tobinaga, Seisho

Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 1 p. 128 - 130 Title/Abstract Full Text View citing articles Show Details

Leung; Walsh; Pulido-Rios; Eglen

British Journal of Pharmacology, 1996 , vol. 117, # 5 p. 926 - 930 Title/Abstract Full Text View citing articles Show Details

Leung; Blissard; Jett; Eglen

Naunyn-Schmiedeberg's Archives of Pharmacology, 1995 , vol. 351, # 6 p. 596 - 602 Title/Abstract Full Text View citing articles Show Details

Ge, Jian; Barnes, Nicholas M.

British Journal of Pharmacology, 1996 , vol. 117, # 7 p. 1475 - 1480 Title/Abstract Full Text View citing articles Show Details

El Mansari; Blier

British Journal of Pharmacology, 1996 , vol. 118, # 3 p. 681 - 689 Title/Abstract Full Text View citing articles Show Details

Haefelinger, Guenter; Nimtz, Manfred; Horstmann, Volker; Benz, Thomas

Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 1999 , vol. 54, # 3 p. 397 - 414 Title/Abstract Full Text View citing articles Show Details

Hela; Anipindi; Priyadarsini; O'Neill

Journal of Physical Chemistry B, 1999 , vol. 103, # 40 p. 8606 - 8611 Title/Abstract Full Text View citing articles Show Details

Wu, Shengde; Janusz, John M.

Tetrahedron Letters, 2000 , vol. 41, # 8 p. 1165 - 1169 Title/Abstract Full Text View citing articles Show Details

Hardcastle

Journal of Pharmacy and Pharmacology, 1999 , vol. 51, # 12 p. 1415 - 1421 Title/Abstract Full Text View citing articles Show Details

Hope, Anthony G.; Peters, John A.; Brown, Angus M.; Lambert, Jeremy J.; Blackburn, Thomas P.

British Journal of Pharmacology, 1996 , vol. 118, # 5 p. 1237 - 1245 Title/Abstract Full Text View citing articles Show Details

Candura; Messori, Eliana; Franceschetti; D'Agostino; Vicini; Tagliani, Monica; Tonini

British Journal of Pharmacology, 1996 , vol. 118, # 8 p. 1965 - 1970 Title/Abstract Full Text View citing articles Show Details

Borea, Pier Andrea; Dalpiaz, Alessandro; Gessi, Stefania; Gilli, Gastone

European Journal of Pharmacology, 1996 , vol. 298, # 3 p. 329 - 334 Title/Abstract Full Text View citing articles Show Details

Budhoo, Misra R.; Harris, R. Paul; Kellum, John M.

European Journal of Pharmacology, 1996 , vol. 298, # 2 p. 137 - 140 Title/Abstract Full Text View citing articles Show Details

Ansanay; Sebben; Bockaert; Dumuis

European Journal of Pharmacology, 1996 , vol. 298, # 2 p. 165 - 174 Title/Abstract Full Text View citing articles Show Details

Terron, Jose A.

British Journal of Pharmacology, 1996 , vol. 118, # 6 p. 1421 - 1428 Title/Abstract Full Text View citing articles Show Details

10 of 239

Comment (Pharmacological Data)

Bioactivities present

Reference

Somei, Masanori; Fukui, Yoshikazu; Hasegawa, Masakazu; Oshikiri, Naoki; Hayashi, Toshikatsu

Heterocycles, 2000 , vol. 53, # 8 p. 1725 - 1736 Title/Abstract Full Text View citing articles Show Details

Glennon, Richard A.; Lee, Mase; Rangisetty, Jagadeesh B.; Dukat, Malgorzata; Roth, Bryan L.; Savage, Jason E.; McBride, Ace; Rauser, Laura; Hufeisen, Sandy; Lee, David K. H.

Journal of Medicinal Chemistry, 2000 , vol. 43, # 5 p. 1011 - 1018 Title/Abstract Full Text View citing articles Show Details

Nakagawa, Hidehiko; Sumiki, Erika; Takusagawa, Mitsuko; Ikota, Nobuo; Matsushima, Yoshikazu; Ozawa, Toshihiko

Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 2 p. 261 - 265 Title/Abstract Full Text View citing articles Show Details

Molinari; North; Dubocovich

European Journal of Pharmacology, 1996 , vol. 301, # 1-3 p. 159 - 168 Title/Abstract Full Text View citing articles Show Details

Pang; Tang; Song; Brown

Life Sciences, 1996 , vol. 58, # 13 p. 1047 - 1057 Title/Abstract Full Text View citing articles Show Details

Leysen; Gommeren; Heylen; Luyten; Van De Weyer; Vanhoenacker; Haegeman; Schotte; Van Gompel; Wouters; Lesage

Molecular Pharmacology, 1996 , vol. 50, # 6 p. 1567 - 1580 Title/Abstract Full Text View citing articles Show Details

Amat; Seffar; Llor; Bosch

Synthesis, 2001 , # 2 p. 267 - 275 Title/Abstract Full Text View citing articles Show Details

Chung, In Hwa; Cha, Ki Suk; Seo, Jae Hong; Kim, Joong Hyup; Chung, Bong Young; Kim, Choong Sup

Heterocycles, 2000 , vol. 53, # 3 p. 529 - 533 Title/Abstract Full Text View citing articles Show Details

Zgombick, John M.; Schechter, Lee E.; Adham, Nika; Kucharewicz, Stefan A.; Weinshank, Richard L.; Branchek, Theresa A.

Naunyn-Schmiedeberg's Archives of Pharmacology, 1996 , vol. 354, # 3 p. 226 - 236 Title/Abstract Full Text View citing articles Show Details

Bard, Jonathan A.; Kucharewicz, Stefan A.; Zgombick, John M.; Weinshank, Richard L.; Branchek, Theresa A.; Cohen, Marlene L.

Naunyn-Schmiedeberg's Archives of Pharmacology, 1996 , vol. 354, # 3 p. 237 - 244 Title/Abstract Full Text View citing articles Show Details

Dalpiaz, Alessandro; Borea, Pier Andrea; Gessi, Stefania; Gilli, Gastone

European Journal of Pharmacology, 1996 , vol. 312, # 1 p. 107 - 114 Title/Abstract Full Text View citing articles Show Details

McLean, Peter G.; Coupar, Ian M.

European Journal of Pharmacology, 1996 , vol. 312, # 2 p. 215 - 225 Title/Abstract Full Text View citing articles Show Details

Pauwels; Palmier; Wurch; Colpaert

Naunyn-Schmiedeberg's Archives of Pharmacology, 1996 , vol. 353, # 2 p. 144 - 156 Title/Abstract Full Text View citing articles Show Details

Adham, Nika; Gerald, Christophe; Schechter, Lee; Vaysse, Pierre; Weinshank, Richard; Branchek, Theresa

European Journal of Pharmacology, 1996 , vol. 304, # 1-3 p. 231 - 235 Title/Abstract Full Text View citing articles Show Details

Hemedah; Coupar; Mitchelson

British journal of pharmacology, 1999 , vol. 126, # 1 p. 179 - 188 Title/Abstract Full Text View citing articles Show Details

Chu, Lin; Lo, Jane-Ling; Yang, Yi-Tien; Cheng, Kang; Smith, Roy G.; Fisher, Michael H.; Wyvratt, Matthew J.; Goulet, Mark T.

Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 515 - 517 Title/Abstract Full Text View citing articles Show Details

Meadows; De Wall; Barbour; Gokel

Journal of the American Chemical Society, 2001 , vol. 123, # 13 p. 3092 - 3107 Title/Abstract Full Text View citing articles Show Details

Wang, Hexiang; Ng, Tzi Bun

Pharmacology and Toxicology, 2000 , vol. 86, # 3 p. 125 - 128 Title/Abstract Full Text View citing articles Show Details

Pouilhes, Annie; Duval-Lungulescu, Monica; Lambel, Stephanie; Leonce, Stephane; Langlois, Yves

Tetrahedron Letters, 2001 , vol. 42, # 47 p. 8297 - 8299 Title/Abstract Full Text View citing articles Show Details

Prins, Nicolaas H.; Briejer, Michel R.; Schuurkes, Jan A.J.

British Journal of Pharmacology, 1997 , vol. 120, # 4 p. 714 - 720 Title/Abstract Full Text View citing articles Show Details

11 of 239

12 of 239

Comment (Pharmacological Data)

Bioactivities present

Reference

Bi, Lanrong; Zhao, Ming; Wang, Chao; Peng, Shiqi; Winterfeldt, Ekkehard

Journal of Organic Chemistry, 2002 , vol. 67, # 1 p. 22 - 26 Title/Abstract Full Text View citing articles Show Details

Centurion, David; Ortiz, Mario I; Sanchez-Lopez, Araceli; De Vries, Peter; Saxena, Pramod R; Villalon, Carlos M

British Journal of Pharmacology, 2001 , vol. 132, # 5 p. 983 - 990 Title/Abstract Full Text View citing articles Show Details

Xue; Voss; Nelson; Duan; Cherney; Jacobson; He; Roderick; Chen; Corbett; Wang; Meyer; Kennedy; Degrado; Hardman; Teleha; Jaffee; Liu; Copeland; Covington; Christ; Trzaskos; Newton; Magolda; Wexler; Decicco

Journal of Medicinal Chemistry, 2001 , vol. 44, # 16 p. 2636 - 2660 Title/Abstract Full Text View citing articles Show Details

Padmanabhan, Seetharamaiyer; Lavin, Ruth C; Thakker, Paresh M; Guo, Jinqing; Zhang, Lu; Moore, Deke; Perlman, Michael E; Kirk, Cassandra; Daly, Deborah; Burke-Howie, Kathy J; Wolcott, Teresa; Chari, Suchitra; Berlove, David; Fischer, James B; Holt, William F; Durant, Graham J; McBurney, Robert N

Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 24 p. 3151 - 3155 Title/Abstract Full Text View citing articles Show Details

Suzuki; Ohuchi; Asanuma; Kaneko; Yokomori; Ito; Isobe; Muramatsu

Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 1 p. 29 - 39 Title/Abstract Full Text View citing articles Show Details

Sacco, Silvano; Aquilini, Luciano; Ghezzi, Pietro; Pinza, Mario; Guglielmotti, Angelo

European Journal of Pharmacology, 1998 , vol. 343, # 2-3 p. 249 - 255 Title/Abstract Full Text View citing articles Show Details

Revial, Gilbert; Jabin, Ivan; Lim, Sethy; Pfau, Michel

Journal of Organic Chemistry, 2002 , vol. 67, # 7 p. 2252 - 2256 Title/Abstract Full Text View citing articles Show Details

Russell; Baker; Barden; Beer; Bristow; Broughton; Knowles; McAllister; Patel; Castro

Journal of Medicinal Chemistry, 2001 , vol. 44, # 23 p. 3881 - 3895 Title/Abstract Full Text View citing articles Show Details

Aubriot, Silvere; Nicolle, Edwige; Lattier, Mireille; Morel, Cecile; Cao, Wenhong; Daniel, Kiefer W.; Collins, Sheila; Leclerc, Gerard; Faure, Patrice

Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 2 p. 209 - 212 Title/Abstract Full Text View citing articles Show Details

Pauwels, Petrus J.; Colpaert, Francis C.

Biochemical Pharmacology, 1995 , vol. 50, # 10 p. 1651 - 1658 Title/Abstract Full Text View citing articles Show Details

Mohanta, Pramod K.; Kim, Kyongtae

Tetrahedron Letters, 2002 , vol. 43, # 22 p. 3993 - 3996 Title/Abstract Full Text View citing articles Show Details

Dubocovich, Margarita L.; Masana, Monica I.; Iacob, Stanca; Sauri, Daniel M.

Naunyn-Schmiedeberg's Archives of Pharmacology, 1997 , vol. 355, # 3 p. 365 - 375 Title/Abstract Full Text View citing articles Show Details

Connors, Richard V.; Zhang, Alex J.; Shuttleworth, Stephen J.

Tetrahedron Letters, 2002 , vol. 43, # 37 p. 6661 - 6663 Title/Abstract Full Text View citing articles Show Details

Lee; Rangisetty; Dukat; Slassi; Maclean; Glennon

Medicinal Chemistry Research, 2000 , vol. 10, # 4 p. 230 - 242 Title/Abstract Full Text View citing articles Show Details

Antilla, Jon C.; Klapars, Artis; Buchwald, Stephen L.

Journal of the American Chemical Society, 2002 , vol. 124, # 39 p. 11684 - 11688 Title/Abstract Full Text View citing articles Show Details

Wu, Tom Y. H.; Schulte, Peter G.

Organic Letters, 2002 , vol. 4, # 23 p. 4033 - 4035 Title/Abstract Full Text View citing articles Show Details

Jiang, Weiqin; Zhang, Xuqing; Sui, Zhihua

Organic letters, 2003 , vol. 5, # 1 p. 43 - 46 Title/Abstract Full Text View citing articles Show Details

Terron

British journal of pharmacology, 1997 , vol. 121, # 3 p. 563 - 571 Title/Abstract Full Text View citing articles Show Details

Bayari; Ide

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2003 , vol. 59, # 6 p. 1255 - 1263 Title/Abstract Full Text View citing articles Show Details

Popova, Galina; Kireev, Vjacheslav; Spitsyn, Alexander; Ihara, Hirotaka; Scherbina, Maxim; Chvalun, Sergei

Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, 2002 , vol. 390, p. 91 - 96 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

Bioactivities present

13 of 239

Reference

Ostrom, Rennolds S.; Ehlert, Frederick J.

Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 280, # 1 p. 189 - 199 Title/Abstract Full Text View citing articles Show Details

Ebersole, Barbara J.; Visiers, Irache; Weinstein, Harel; Sealfon, Stuart C.

Molecular Pharmacology, 2003 , vol. 63, # 1 p. 36 - 43 Title/Abstract Full Text View citing articles Show Details

He, Ling; Li, Ju-Lian; Zhang, Jian-Jun; Su, Pu; Zheng, Shi-Long

Synthetic Communications, 2003 , vol. 33, # 5 p. 741 - 747 Title/Abstract Full Text View citing articles Show Details

Glennon, Richard A.

Journal of Medicinal Chemistry, 2003 , vol. 46, # 14 p. 2795 - 2812 Title/Abstract Full Text View citing articles Show Details

Castro, Alfredo C.; Dang, Luan C.; Soucy, Francois; Grenier, Louis; Mazdiyasni, Hormoz; Hottelet, Maria; Parent, Lana; Pien, Christine; Palombella, Vito; Adams, Julian

Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 14 p. 2419 - 2422 Title/Abstract Full Text View citing articles Show Details

Kiso, Tetsuo; Ito, Hiroyuki; Miyata, Keiji

European Journal of Pharmacology, 1997 , vol. 320, # 2-3 p. 187 - 192 Title/Abstract Full Text View citing articles Show Details

Karimi, Farhad; Langstroem, Bengt

European Journal of Organic Chemistry, 2003 , # 11 p. 2132 - 2137 Title/Abstract Full Text View citing articles Show Details

Thomson, Douglas W.; Commeureuc, Aurelien G. J.; Berlin, Stefan; Murphy, John A.

Synthetic Communications, 2003 , vol. 33, # 20 p. 3631 - 3641 Title/Abstract Full Text View citing articles Show Details

Remiszewski, Stacy W.; Sambucetti, Lidia C.; Bair, Kenneth W.; Bontempo, John; Cesarz, David; Chandramouli, Nagarajan; Chen, Ru; Cheung, Min; Cornell-Kennon, Susan; Dean, Karl; Diamantidis, George; France, Dennis; Green, Michael A.; Howell, Kobporn Lulu; Kashi, Rina; Kwon, Paul; Lassota, Peter; Martin, Mary S.; Mou, Yin; Perez, Lawrence B.; Sharma, Sushil; Smith, Troy; Sorensen, Eric; Taplin, Francis; Trogani, Nancy; Versace, Richard; Walker, Heather; Weltchek-Engler, Susan; Wood, Alexander; Wu, Arthur; Atadja, Peter

Journal of Medicinal Chemistry, 2003 , vol. 46, # 21 p. 4609 - 4624 Title/Abstract Full Text View citing articles Show Details

Janssen; Prins; Meulemans; Lefebvre

British Journal of Pharmacology, 2002 , vol. 136, # 2 p. 321 - 329 Title/Abstract Full Text View citing articles Show Details

Zhang, Zhang-Jin; Trivedi, Bakula L.; De Paulis, Tomas; Schmidt, Dennis E.; Hewlett, William A.

Naunyn-Schmiedeberg's Archives of Pharmacology, 2002 , vol. 365, # 2 p. 123 - 132 Title/Abstract Full Text View citing articles Show Details

Ito, Chika; Isobe, Yoshihiko; Kawamura, Reiko; Kiuchi, Yoichi; Tsuchida, Katsuharu; Higuchi, Shohei

Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 280, # 1 p. 67 - 72 Title/Abstract Full Text View citing articles Show Details

Amemiya, Norihito; Hatta, Shinichi; Takemura, Haruo; Ohshika, Hideyo

European Journal of Pharmacology, 1996 , vol. 318, # 2-3 p. 403 - 409 Title/Abstract Full Text View citing articles Show Details

Jayaprakasam, Bolleddula; Strasburg, Gale A.; Nair, Muraleedharan G.

Tetrahedron, 2004 , vol. 60, # 13 p. 3109 - 3121 Title/Abstract Full Text View citing articles Show Details

Dukat, Malgorzata; Smith, Carol; Herrick-Davis, Katharine; Teitler, Milt; Glennon, Richard A.

Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 10 p. 2545 - 2552 Title/Abstract Full Text View citing articles Show Details

Taylor, Mark S.; Jacobsen, Eric N.

Journal of the American Chemical Society, 2004 , vol. 126, # 34 p. 10558 - 10559 Title/Abstract Full Text View citing articles Show Details

Chimia, 2004 , vol. 58, # 9 p. 613 - 620 Title/Abstract Full Text View citing articles Show Details

Domenech; Beleta; Palacios

Naunyn-Schmiedeberg's Archives of Pharmacology, 1997 , vol. 356, # 3 p. 328 - 334 Title/Abstract Full Text View citing articles Show Details

Gurkan, A. Selen; Karabay, Arzu; Buyukbingol, Zeliha; Adejare, Adeboye; Buyukbingol, Erdem

Archiv der Pharmazie, 2005 , vol. 338, # 2-3 p. 67 - 73 Title/Abstract Full Text View citing articles Show Details

Holenz, Joerg; Merce, Ramon; Diaz, Jose Luis; Guitart, Xavier; Codony, Xavier; Dordal, Alberto; Romero, Gonzalo; Torrens, Antoni; Mas, Josep; Andaluz, Blas; Hernandez, Susana; Monroy, Xavier; Sanchez, Elisabeth; Hernandez, Enrique; Perez, Raquel; Cubi, Roger; Sanfeliu, Olga; Buschmann, Helmut

Journal of Medicinal Chemistry, 2005 , vol. 48, # 6 p. 1781 - 1795 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

Bioactivities present

Reference

Zlotos, Darius P.

Archiv der Pharmazie, 2005 , vol. 338, # 5-6 p. 229 - 247 Title/Abstract Full Text View citing articles Show Details

Kloda, Anna; Adams, David J.

British Journal of Pharmacology, 2005 , vol. 144, # 3 p. 323 - 330 Title/Abstract Full Text View citing articles Show Details

May, Jesse A.; McLaughlin, Marsha A.; Sharif, Najam A.; Hellberg, Mark R.; Dean, Thomas R.

Journal of Pharmacology and Experimental Therapeutics, 2003 , vol. 306, # 1 p. 301 - 309 Title/Abstract Full Text View citing articles Show Details

Harada, Hiroshi; Hirokawa, Yoshimi; Suzuki, Kenji; Hiyama, Yoichi; Oue, Mayumi; Kawashima, Hitoshi; Kato, Hiroshi; Yoshida, Naoyuki; Furutani, Yasuji; Kato, Shiro

Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 2 p. 184 - 198 Title/Abstract Full Text View citing articles Show Details

Ates-Alagoz; Buyukbingol; Buyukbingol, Erdem

Pharmazie, 2005 , vol. 60, # 9 p. 643 - 647

Title/Abstract Full Text View citing articles Show Details

Hirst, Warren D.; Abrahamsen, Bjarke; Blaney, Frank E.; Calver, Andrew R.; Aloj, Lucia; Price, Gary W.; Medhurst, Andrew D.

Molecular Pharmacology, 2003 , vol. 64, # 6 p. 1295 - 1308 Title/Abstract Full Text View citing articles Show Details

Berg, Kelly A.; Maayani, Saul; Goldfarb, Joseph; Scaramellini, Clare; Leff, Paul; Clarke, William P.

Molecular Pharmacology, 1998 , vol. 54, # 1 p. 94 - 104 Title/Abstract Full Text View citing articles Show Details

De Vries; Villalon; Heiligers; Saxena

Naunyn-Schmiedeberg's archives of pharmacology, 1997 , vol. 356, # 1 p. 90 - 99 Title/Abstract Full Text View citing articles Show Details

Cheve, Gwenael; Duriez, Patrick; Fruchart, Jean-Charles; Teissier, Elisabeth; Poupaert, Jacques; Lesieur, Daniel

Medicinal Chemistry Research, 2002 , vol. 11, # 7 p. 361 - 379 Title/Abstract Full Text View citing articles Show Details

Narimatsu, Shizuo; Yonemoto, Rei; Saito, Keita; Takaya, Kazuo; Kumamoto, Takuya; Ishikawa, Tsutomu; Asanuma, Masato; Funada, Masahiko; Kiryu, Kimio; Naito, Shinsaku; Yoshida, Yuzo; Yamamoto, Shigeo; Hanioka, Nobumitsu

Biochemical Pharmacology, 2006 , vol. 71, # 9 p. 1377 - 1385 Title/Abstract Full Text View citing articles Show Details

Iskander, Magdy N.; Leung, Lok M.; Buley, Trevor; Ayad, Fadi; Di Iulio, Juliana; Tan, Yean Y.; Coupar, Ian M.

European Journal of Medicinal Chemistry, 2006 , vol. 41, # 1 p. 16 - 26 Title/Abstract Full Text View citing articles Show Details

Chernov; Shul'ts; Shakirov; Tolstikov

Russian Journal of Organic Chemistry, 2006 , vol. 42, # 6 p. 828 - 838 Title/Abstract Full Text View citing articles Show Details

Ates-Alagoz, Zeynep; Coban, Tulay; Buyukbingol, Erdem

Archiv der Pharmazie, 2006 , vol. 339, # 4 p. 193 - 200 Title/Abstract Full Text View citing articles Show Details

Van Tilburg, Erica W.; Windhorst, Albert D.; Van Der Mey, Margreet; Herscheid, Jacobus D. M.

Journal of Labelled Compounds and Radiopharmaceuticals, 2006 , vol. 49, # 4 p. 321 - 330 Title/Abstract Full Text View citing articles Show Details

Venkatachalam; Salaskar; Chattopadhyay; Barik; Mishra; Gangabhagirathi; Priyadarsini

Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 18 p. 6414 - 6419 Title/Abstract Full Text View citing articles Show Details

Somei, Masanori; Iwaki, Takako; Yamada, Fumio; Tanaka, Yoshio; Shigenobu, Koki; Koike, Katsuo; Suzuki, Nobuo; Hattori, Atsuhiko

Heterocycles, 2006 , vol. 68, # 8 p. 1565 - 1569 Title/Abstract Full Text View citing articles Show Details

Costagli, Chiara; Galli, Alessandro

Biochemical Pharmacology, 1998 , vol. 55, # 10 p. 1733 - 1737 Title/Abstract Full Text View citing articles Show Details

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 66, # 1 p. 171 - 176 Title/Abstract Full Text View citing articles Show Details

Enzensperger, Christoph; Kilian, Susann; Ackermann, Marit; Koch, Anne; Kelch, Kristin; Lehmann, Jochen

Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1399 - 1402 Title/Abstract Full Text View citing articles Show Details

Sogawa; Tagawa; Fujino; Ohyama; Asanuma; Funada; Kitayama

Toxicology Letters, 2007 , vol. 170, # 1 p. 75 - 82 Title/Abstract Full Text View citing articles Show Details

14 of 239

Comment (Pharmacological Data)

Bioactivities present

Reference

Suckling, Colin J.; Murphy, John A.; Khalaf, Abedawn I.; Zhou, Sheng-ze; Lizos, Dimitris E.; van Nhien, Albert Nguyen; Yasumatsu, Hiroshi; McVie, Allan; Young, Louise C.; McCraw, Corinna; Waterman, Peter G.; Morris, Brian J.; Pratt, Judith A.; Harvey, Alan L.

Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2649 - 2655 Title/Abstract Full Text View citing articles Show Details

Vickery; Mai; Kaufman; Beattie; Pulido-Rios; O'Keefe; Humphrey; Smith

British Journal of Pharmacology, 2007 , vol. 150, # 6 p. 782 - 791 Title/Abstract Full Text View citing articles Show Details

Scott, William L.; Martynow, Jacek G.; Huffman, John C.; O'Donnell, Martin J.

Journal of the American Chemical Society, 2007 , vol. 129, # 22 p. 7077 - 7088 Title/Abstract Full Text View citing articles Show Details

Choo, Yeun-Mun; Hamann, Mark T.

Heterocycles, 2007 , vol. 71, # 2 p. 245 - 252 Title/Abstract Full Text View citing articles Show Details

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 3 p. 927 - 941 Title/Abstract Full Text View citing articles Show Details

Trujillo, John I.; Meyers, Marvin J.; Anderson, David R.; Hegde, Shridhar; Mahoney, Matthew W.; Vernier, William F.; Buchler, Ingrid P.; Wu, Kun K.; Yang, Syaluan; Hartmann, Susan J.; Reitz, David B.

Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4657 - 4663 Title/Abstract Full Text View citing articles Show Details

Di Giacomo, Barbara; Bedini, Annalida; Spadoni, Gilberto; Tarzia, Giorgio; Fraschini, Franco; Pannacci, Marilou; Lucini, Valeria

Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 13 p. 4643 - 4650 Title/Abstract Full Text View citing articles Show Details

Bower, Kiowa S.; Price, Kerry L.; Sturdee, Laura E.C.; Dayrell, Mariza; Dougherty, Dennis A.; Lummis, Sarah C.R.

European Journal of Pharmacology, 2008 , vol. 580, # 3 p. 291 - 297 Title/Abstract Full Text View citing articles Show Details

Shestakov; Sidorenko; Shikhaliev; Pavlenko

Russian Journal of General Chemistry, 2007 , vol. 77, # 10 p. 1749 - 1760 Title/Abstract Full Text View citing articles Show Details

Baylor College of Medicine

Patent: US5424185 A1, 1995 ; Title/Abstract Full Text Show Details

Zisapel; Nava; Laudon; Moshe

Patent: US4880826 A1, 1989 ;

Title/Abstract Full Text Show Details

Instituto Farmacologico Lombardo-IFLO, S.a.S.

Patent: US5552428 A1, 1996 ; Title/Abstract Full Text Show Details

Sankyo Company, Limited

Patent: US6013663 A1, 2000 ; Title/Abstract Full Text Show Details

Raheem, Izzat T.; Thiara, Parvinder S.; Peterson, Emily A.; Jacobsen, Eric N.

Journal of the American Chemical Society, 2007 , vol. 129, # 44 p. 13404 - 13405 Title/Abstract Full Text View citing articles Show Details

Soriano-Agaton, Flor; Lagoutte, Delphine; Poupon, Erwan; Roblot, Francois; Fournet, Alain; Gantier, Jean-Charles; Hocquemiller, Reynald

Journal of Natural Products, 2005 , vol. 68, # 11 p. 1581 - 1587 Title/Abstract Full Text View citing articles Show Details

Shishido, Yuji; Jinno, Madoka; Ikeda, Takafumi; Ito, Fumitaka; Sudo, Masaki; Makita, Naoya; Ohta, Atsuko; Iki-Taki, Ayako; Ohmi, Takashi; Kanai, Yoshihito; Tamura, Tetsuya; Shimojo, Masato

Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 3 p. 1072 - 1078 Title/Abstract Full Text View citing articles Show Details

Sharma, Neera; Jain, Sapan K.; Rastogi, Ramesh C.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2008 , vol. 69, # 3 p. 748 - 756 Title/Abstract Full Text View citing articles Show Details

Passarella, Daniele; Belinghieri, Francesca; Scarpellini, Michele; Pratesi, Graziella; Zunino, Franco; Gia, Ornella Maria; Via, Lisa Dalla; Santoro, Giuseppe; Danieli, Bruno

Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 5 p. 2431 - 2438 Title/Abstract Full Text View citing articles Show Details

Mumford, Peter M.; Shiers, Jason J.; Tarver, Gary J.; Hayes, Jerome F.; Shipman, Michael

Tetrahedron Letters, 2008 , vol. 49, # 21 p. 3489 - 3491 Title/Abstract Full Text View citing articles Show Details

Lukehart; Raja

Inorganic Chemistry, 1982 , vol. 21, # 3 p. 1278 - 1280 Title/Abstract Full Text View citing articles Show Details

15 of 239

Comment (Pharmacological Data)

Bioactivities present

Reference

THE JOHNS HOPKINS UNIVERSITY

Patent: WO2008/124660 A2, 2008 ; Title/Abstract Full Text Show Details

NEURIM PHARMACEUTICALS (1991) LTD.

Patent: US2008/132559 A1, 2008 ; Title/Abstract Full Text Show Details

Gobbi, Luca; Knust, Henner; Malherbe, Parichehr; Nettekoven, Matthias; Pinard, Emmanuel; Roche, Olivier; Rogers-Evans, Mark

Patent: US2008/249125 A1, 2008 ; Title/Abstract Full Text Show Details

Celik, Leyla; Sinning, Steffen; Severinsen, Kasper; Hansen, Carsten G.; Moller, Maria S.; Bols, Mikael; Wiborg, Ove; Schiott, Birgit

Journal of the American Chemical Society, 2008 , vol. 130, # 12 p. 3853 - 3865 Title/Abstract Full Text View citing articles Show Details

Yerkes, Nancy; Wu, Jia Xin; McCoy, Elizabeth; Galan, M. Carmen; Chen, Shi; O'Connor, Sarah E.

Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 10 p. 3095 - 3098 Title/Abstract Full Text View citing articles Show Details

Kiviranta, Paeivi H.; Salo, Heikki S.; Leppaenen, Jukka; Rinne, Valtteri M.; Kyrylenko, Sergiy; Kuusisto, Erkki; Suuronen, Tiina; Salminen, Antero; Poso, Antti; Lahtela-Kakkonen, Maija; Wallen, Erik A.A.

Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 17 p. 8054 - 8062 Title/Abstract Full Text View citing articles Show Details

SEQUELLA, INC.

Patent: WO2005/34857 A2, 2005 ; Title/Abstract Full Text Show Details

Kulkarni, Aditya; Abid, Mohammed; Toeroek, Bela; Huang, Xudong

Tetrahedron Letters, 2009 , vol. 50, # 16 p. 1791 - 1794 Title/Abstract Full Text View citing articles Show Details

Klausen, Rebekka S.; Jacobsen, Eric N.

Organic Letters, 2009 , vol. 11, # 4 p. 887 - 890 Title/Abstract Full Text View citing articles Show Details

Delgado, Rieardo; Blakey, Simon B.

European Journal of Organic Chemistry, 2009 , # 10 p. 1506 - 1510 Title/Abstract Full Text View citing articles Show Details

Bou-Hamdan, Farhan R.; Leighton, James L.

Angewandte Chemie, International Edition, 2009 , vol. 48, # 13 p. 2403 - 2406 Title/Abstract Full Text View citing articles Show Details

Hanna-Elias, Amir; Manallack, David T.; Berque-Bestel, Isabelle; Irving, Helen R.; Coupar, Ian M.; Iskander, Magdy N.

Australian Journal of Chemistry, 2009 , vol. 62, # 2 p. 150 - 156 Title/Abstract Full Text View citing articles Show Details

Chen, Zhuo; Hu, Gaoyun; Li, Dai; Chen, Jun; Li, Yuanjian; Zhou, Huayong; Xie, Ye

Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 6 p. 2351 - 2359 Title/Abstract Full Text View citing articles Show Details

Hanna-Elias, Amir; Manallack, David T.; Berque-Bestel, Isabelle; Irving, Helen R.; Coupar, Ian M.; Iskander, Magdy N.

European Journal of Medicinal Chemistry, 2009 , vol. 44, # 7 p. 2952 - 2959 Title/Abstract Full Text View citing articles Show Details

Alyab'ev; Kravchenko; Ivashchenko

Russian Journal of Organic Chemistry, 2009 , vol. 45, # 5 p. 719 - 724

Title/Abstract Full Text View citing articles Show Details

Luo, Xin-Feng; He, Ling; Yin, Hai-Bin; Zheng, Hu; Bei, Di; Deng, Jin-Jin; Huang, Wen-Cai

Synthetic Communications, 2009 , vol. 39, # 19 p. 3444 - 3452 Title/Abstract Full Text View citing articles Show Details

Aventis Pharma Limited

Patent: US6352977 B1, 2002 ; Title/Abstract Full Text Show Details

Schreiber, Stuart L.; Stavenger, Robert A.; Mitchison, Timothy J.; Maliga, Zoltan

Patent: US2004/59138 A1, 2004 ; Title/Abstract Full Text Show Details

WYETH

Patent: WO2004/24734 A1, 2004 ; Title/Abstract Full Text Show Details

The Procter and Gamble Company

Patent: US6784293 B1, 2004 ; Title/Abstract Full Text Show Details

16 of 239

Comment (Pharmacological Data)

Bioactivities present

Reference

Neurim Pharmaceuticals (1991) Ltd.

Patent: US6858642 B1, 2005 ; Title/Abstract Full Text Show Details

Infinity Pharmaceuticals, Inc.

Patent: US2006/20004 A1, 2006 ; Title/Abstract Full Text Show Details

Miller, John F.; Turner, Elizabeth M.; Sherrill, Ronald G.; Gudmundsson, Kristjan; Spaltenstein, Andrew; Sethna, Phiroze; Brown, Kevin W.; Harvey, Robert; Romines, Karen R.; Golden, Pamela

Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 1 p. 256 - 259 Title/Abstract Full Text View citing articles Show Details

Phutdhawong, Waya S.; Ruensamran, Wanwikar; Phutdhawong, Weerachai; Taechowisan, Thongchai

Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 19 p. 5753 - 5756 Title/Abstract Full Text View citing articles Show Details

Peng, Jiangnan; Kudrimoti, Sucheta; Prasanna, Sivaprakasam; Odde, Srinivas; Doerksen, Robert J.; Pennaka, Hari K.; Choo, Yeun-Mun; Rao, Karumanchi V.; Tekwani, Babu L.; Madgula, Vamsi; Khan, Shabana I.; Wang, Bin; Mayer, Alejandro M. S.; Jacob, Melissa R.; Tu, Lan Chun; Gertsch, Juerg; Hamann, Mark T.

Journal of Medicinal Chemistry, 2010 , vol. 53, # 1 p. 61 - 76 Title/Abstract Full Text View citing articles Show Details

White, James D.; Li, Yang; Ihle, David C.

Journal of Organic Chemistry, 2010 , vol. 75, # 11 p. 3569 - 3577 Title/Abstract Full Text View citing articles Show Details

LES LABORATOIRES SERVIER

Patent: US2010/204276 A1, 2010 ; Title/Abstract Full Text Show Details

Wu, Xiaoyu; Dai, Xiaoyang; Nie, Linlin; Fang, Huihui; Chen, Jie; Ren, Zhongjiao; Cao, Weiguo; Zhao, Gang

Chemical Communications, 2010 , vol. 46, # 16 p. 2733 - 2735 Title/Abstract Full Text View citing articles Show Details

Zhou, Yu; Zhai, Yun; Li, Jian; Ye, Deju; Jiang, Hualiang; Liu, Hong

Green Chemistry, 2010 , vol. 12, # 8 p. 1397 - 1404 Title/Abstract Full Text View citing articles Show Details

GRUeNENTHAL GMBH

Patent: WO2006/18184 A2, 2006 ; Title/Abstract Full Text Show Details

Bi, Wei; Bi, Yue; Xue, Ping; Zhang, Yanrong; Gao, Xiang; Wang, Zhibo; Li, Meng; Baudy-Floch, Michele; Ngerebara, Nathaniel; Gibson, K. Michael; Bi, Lanrong

Journal of Medicinal Chemistry, 2010 , vol. 53, # 18 p. 6763 - 6767 Title/Abstract Full Text View citing articles Show Details

Gastaminza, Pablo; Whitten-Bauer, Christina; Chisari, Francis V.

Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 1 p. 291 - 296 Title/Abstract Full Text View citing articles Show Details

Barker, Emma; Jensen, Annika Jenmalm; Nordling, Erik; Proud, Andrew; Slater, Martin; Weber, Michael; Tedenborg, Lars

Patent: US2006/217375 A1, 2006 ; Title/Abstract Full Text Show Details

NEURIM PHARMACEUTICALS (1991) LTD.

Patent: WO2007/93880 A2, 2007 ; Title/Abstract Full Text Show Details

Holloway, Chloe A.; Muratore, Michael E.; Storer, R. Lan; Dixon, Darren J.

Organic Letters, 2010 , vol. 12, # 21 p. 4720 - 4723 Title/Abstract Full Text View citing articles Show Details

Defalco, Jeff; Steiger, Daniel; Dourado, Michelle; Emerling, Daniel; Duncton, Matthew A.J.

Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 23 p. 7076 - 7079 Title/Abstract Full Text View citing articles Show Details

Benkovics, Tamas; Guzei, Ilia A.; Yoon, Tehshik P.

Angewandte Chemie - International Edition, 2010 , vol. 49, # 48 p. 9153 - 9157 Title/Abstract Full Text View citing articles Show Details

Zhang, Shou-Hua; Wang, Chun-Ye; Jiang, Zhen-Zhou; Ni, Pei-Zhou; Zhou, Jin-Pei; Xi, Bao-Min; Chen, Wen-Hua

Chemical and Pharmaceutical Bulletin, 2011 , vol. 59, # 1 p. 96 - 99 Title/Abstract Full Text View citing articles Show Details

Fang, Huihui; Wu, Xiaoyu; Nie, Linlin; Dai, Xiaoyang; Chen, Jie; Cao, Weiguo; Zhao, Gang

Organic Letters, 2010 , vol. 12, # 23 p. 5366 - 5369 Title/Abstract Full Text View citing articles Show Details

Finlayson, Rhys; Brackovic, Amira; Simon-Levert, Annabel; Banaigs, Bernard; O'Toole, Ronan F.; Miller, Christopher H.; Copp, Brent R.

Tetrahedron Letters, 2011 , vol. 52, # 7 p. 837 - 840 Title/Abstract Full Text View citing articles Show Details

17 of 239

Comment (Pharmacological Data)

Bioactivities present

Reference

HERCULES TECHNOLOGY MANAGEMENT CO V, INC.; BLAGG, Julian

Patent: WO2011/47156 A1, 2011 ; Title/Abstract Full Text Show Details

Dai, Xiaoyang; Wu, Xiaoyu; Fang, Huihui; Nie, Linlin; Chen, Jie; Deng, Hongmei; Cao, Weiguo; Zhao, Gang

Tetrahedron, 2011 , vol. 67, # 17 p. 3034 - 3040 Title/Abstract Full Text View citing articles Show Details

DUKE UNIVERSITY

Patent: US2011/112073 A1, 2011 ; Title/Abstract Full Text Show Details

Duce, Sara; Pesciaioli, Fabio; Gramigna, Lucia; Bernardi, Luca; Mazzanti, Andrea; Ricci, Alfredo; Bartoli, Giuseppe; Bencivenni, Giorgio

Advanced Synthesis and Catalysis, 2011 , vol. 353, # 6 p. 860 - 864 Title/Abstract Full Text View citing articles Show Details

Nicolaou; Kiappes; Tian, Weiwei; Gondi, Vijaya B.; Becker, Jochen

Organic Letters, 2011 , vol. 13, # 15 p. 3924 - 3927 Title/Abstract Full Text View citing articles Show Details

Wu, Xiaoyu; Fang, Huihui; Liu, Qin; Nie, Linlin; Chen, Jie; Cao, Weiguo; Zhao, Gang

Tetrahedron, 2011 , vol. 67, # 38 p. 7251 - 7257 Title/Abstract Full Text View citing articles Show Details

Zhang, Pu Yong; Wan, Sheng Biao; Ren, Su Mei; Jiang, Tao

Chinese Chemical Letters, 2010 , vol. 21, # 11 p. 1307 - 1309 Title/Abstract Full Text View citing articles Show Details

Wu, Xiaoyu; Dai, Xiaoyang; Fang, Huihui; Nie, Linlin; Chen, Jie; Cao, Weiguo; Zhao, Gang

Chemistry - A European Journal, 2011 , vol. 17, # 38 p. 10510 - 10514 Title/Abstract Full Text View citing articles Show Details

Badillo, Joseph J.; Silva-Garcia, Abel; Shupe, Benjamin H.; Fettinger, James C.; Franz, Annaliese K.

Tetrahedron Letters, 2011 , vol. 52, # 43 p. 5550 - 5553 Title/Abstract Full Text View citing articles Show Details

Lallemand, Benjamin; Chaix, Fabien; Bury, Marina; Bruyere, Celine; Ghostin, Jean; Becker, Jean-Paul; Delporte, Cedric; Gelbcke, Michel; Mathieu, Veronique; Dubois, Jacques; Prevost, Martine; Jabin, Ivan; Kiss, Robert

Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6501 - 6513 Title/Abstract Full Text View citing articles Show Details

PHARMA MAR, S.A.; MARTIN LOPEZ, M Jesus; FRANCESCH SOLLOSO, Andres; CUEVAS MARCHANTE, Maria del Carmen

Patent: WO2011/147828 A1, 2011 ; Title/Abstract Full Text Show Details

Shan, Wen-Jun; Huang, Ling; Zhou, Qi; Meng, Fan-Chao; Li, Xing-Shu

European Journal of Medicinal Chemistry, 2011 , vol. 46, # 12 p. 5885 - 5893 Title/Abstract Full Text View citing articles Show Details

Alam, Athar; Pal, Chinmay; Goyal, Manish; Kundu, Milan Kumar; Kumar, Rahul; Iqbal, Mohd Shameel; Dey, Sumanta; Bindu, Samik; Sarkar, Souvik; Pal, Uttam; Maiti, Nakul C.; Adhikari, Susanta; Bandyopadhyay, Uday

Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 24 p. 7365 - 7373 Title/Abstract Full Text View citing articles Show Details

Jiang, Huailei; Wang, Xu; Huang, Ling; Luo, Zonghua; Su, Tao; Ding, Ke; Li, Xingshu

Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 23 p. 7228 - 7235 Title/Abstract Full Text View citing articles Show Details

Teichert, Johannes F.; Fananas-Mastral, Martin; Feringa, Ben L.

Synthesis, 2012 , vol. 44, # 3 art. no. T104711SS, p. 409 - 416 Title/Abstract Full Text View citing articles Show Details

Klochkov; Afanas'eva; Ermatova; Chudinov

Chemistry of Natural Compounds, 2011 , vol. 47, # 5 p. 716 - 725 Title/Abstract Full Text View citing articles Show Details

Cuny, Gregory D.; Ulyanova, Natalia P.; Patnaik, Debasis; Liu, Ji-Feng; Lin, Xiangjie; Auerbach, Ken; Ray, Soumya S.; Xian, Jun; Glicksman, Marcie A.; Stein, Ross L.; Higgins, Jonathan M.G.

Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 5 p. 2015 - 2019 Title/Abstract Full Text View citing articles Show Details

Huang, Dan; Xu, Fangxi; Lin, Xufeng; Wang, Yanguang

Chemistry - A European Journal, 2012 , vol. 18, # 11 p. 3148 - 3152 Title/Abstract Full Text View citing articles Show Details

Ascic, Erhad; Hansen, Casper L.; Le Quement, Sebastian T.; Nielsen, Thomas E.

Chemical Communications, 2012 , vol. 48, # 27 p. 3345 - 3347 Title/Abstract Full Text View citing articles Show Details

Hanna-Elias, Amir; Manallack, David T.; Levit, Alla; Nguyen, William; Ayad, Fadi; Perera, Glen; Shapiro, Marina; Irving, Helen R.; Coupar, Ian M.; Iskander, Magdy N.

Medicinal Chemistry, 2010 , vol. 6, # 6 p. 344 - 354 Title/Abstract Full Text View citing articles Show Details

18 of 239

Comment (Pharmacological Data)

Bioactivities present

Reference

MacDonald, Jacob P.; Badillo, Joseph J.; Arevalo, Gary E.; Silva-Garcia, Abel; Franz, Annaliese K.

ACS Combinatorial Science, 2012 , vol. 14, # 4 p. 285 - 293

Title/Abstract Full Text View citing articles Show Details

Khorana, Nantaka; Changwichit, Kanokwan; Ingkaninan, Kornkanok; Utsintong, Maleeruk

Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2885 - 2888 Title/Abstract Full Text View citing articles Show Details

Dueckert, Heiko; Pries, Verena; Khedkar, Vivek; Menninger, Sascha; Bruss, Hanna; Bird, Alexander W.; Maliga, Zoltan; Brockmeyer, Andreas; Janning, Petra; Hyman, Anthony; Grimme, Stefan; Schuermann, Markus; Preut, Hans; Huebel, Katja; Ziegler, Slava; Kumar, Kamal; Waldmann, Herbert

Nature Chemical Biology, 2012 , vol. 8, # 2 p. 179 - 184 Title/Abstract Full Text View citing articles Show Details

Pal, Chinmay; Bindu, Samik; Dey, Sumanta; Alam, Athar; Goyal, Manish; Iqbal, Mohd Shameel; Sarkar, Souvik; Kumar, Rahul; Halder, Kamal Krishna; Debnath, Mita Chatterjee; Adhikari, Susanta; Bandyopadhyay, Uday

Journal of Biological Chemistry, 2012 , vol. 287, # 5 p. 3495 - 3509 Title/Abstract Full Text View citing articles Show Details

Jida, Mouhamad; Soueidan, Olivier-Mohamad; Deprez, Benoit; Laconde, Guillaume; Deprez-Poulain, Rebecca

Green Chemistry, 2012 , vol. 14, # 4 p. 909 - 911 Title/Abstract Full Text View citing articles Show Details

Zi, Weiwei; Xie, Weiqing; Ma, Dawei

Journal of the American Chemical Society, 2012 , vol. 134, # 22 p. 9126 - 9129 Title/Abstract Full Text View citing articles Show Details

Modha, Sachin G.; Vachhani, Dipak D.; Jacobs, Jeroen; Van Meervelt, Luc; Van Der Eycken, Erik V.

Chemical Communications, 2012 , vol. 48, # 52 p. 6550 - 6552 Title/Abstract Full Text View citing articles Show Details

Berger; Palangsuntikul; Rebernik; Wolschann; Berner

Current Medicinal Chemistry, 2012 , vol. 19, # 18 p. 3044 - 3057 Title/Abstract Full Text View citing articles Show Details

Klochkov; Afanas'eva; Pukhov

Chemistry of Heterocyclic Compounds, 2012 , vol. 48, # 2 p. 384 - 385 Title/Abstract Full Text View citing articles Show Details

Nirogi, Ramakrishna V.S.; Kambhampati, Ramasastri; Kothmirkar, Prabhakar; Konda, Jagadishbabu; Bandyala, Thrinath Reddy; Gudla, Parandhama; Arepalli, Sobhanadri; Gangadasari, Narasimhareddy P.; Shinde, Anil K.; Deshpande, Amol D.; Dwarampudi, Adireddy; Chindhe, Anil K.; Dubey, Pramod Kumar

Journal of Enzyme Inhibition and Medicinal Chemistry, 2012 , vol. 27, # 3 p. 443 - 450 Title/Abstract Full Text View citing articles Show Details

Liu, Lianzhu; Zhang, Liming

Angewandte Chemie - International Edition, 2012 , vol. 51, # 29 p. 7301 - 7304 Title/Abstract Full Text View citing articles Show Details

Albrecht, Anna; Morana, Fabio; Fraile, Alberto; Jørgensen, Karl Anker

Chemistry - A European Journal, 2012 , vol. 18, # 33 p. 10348 - 10354 Title/Abstract Full Text View citing articles Show Details

Perlovich, German L.; Proshin, Alexey N.; Volkova, Tatyana V.; Petrova, Ludmila N.; Bachurin, Sergey O.

Molecular Pharmaceutics, 2012 , vol. 9, # 8 p. 2156 - 2167 Title/Abstract Full Text View citing articles Show Details

CHEMILIA AB; HOeGBERG, Marita; DAHLSTEDT, Emma; SMITT, Olof; JOHANSSON, Tommy

Patent: WO2012/127032 A1, 2012 ; Title/Abstract Full Text Show Details

Dong, Guoqiang; Wang, Shengzheng; Miao, Zhenyuan; Yao, Jianzhong; Zhang, Yongqiang; Guo, Zizhao; Zhang, Wannian; Sheng, Chunquan

Journal of Medicinal Chemistry, 2012 , vol. 55, # 17 p. 7593 - 7613 Title/Abstract Full Text View citing articles Show Details

Gore, Sangram; Baskaran, Sundarababu; König, Burkhard

Organic Letters, 2012 , vol. 14, # 17 p. 4568 - 4571 Title/Abstract Full Text View citing articles Show Details

Zhu, Hai-Liang; Ling, Jun-Bing; Xu, Peng-Fei

Journal of Organic Chemistry, 2012 , vol. 77, # 17 p. 7737 - 7743,7 Title/Abstract Full Text Show Details

Patel, Paresh K.; Patel, Rahul V.; Mehta, Girish N.; Mahajan, Dharmesh H.; Parikh, Parimal A.; Chikhalia, Kishor H.

Medicinal Chemistry Research, 2012 , vol. 21, # 10 p. 3182 - 3194,13 Title/Abstract Full Text Show Details

Sanaboina, Chakrapani; Jana, Samaresh; Chidara, Sridhar; Patro, Balaram; Raolji, Gajendrasinh Balvantsinh; Eppakayala, Laxminarayana

Tetrahedron Letters, 2012 , vol. 53, # 37 p. 5027 - 5029,3 Title/Abstract Full Text Show Details

Kitson, Sean L.

Current Pharmaceutical Design, 2007 , vol. 13, # 25 p. 2621 - 2637 Title/Abstract Full Text View citing articles Show Details

19 of 239

Comment (Pharmacological Data)

Bioactivities present

Reference

Anisimova; Spasov; Kosolapov; Tolpygin; Porotikov; Kucheryavenko; Sysoeva; Tibir'kova; El'tsova

Pharmaceutical Chemistry Journal, 2009 , vol. 43, # 9 p. 491 - 494 Title/Abstract Full Text View citing articles Show Details

Huang, Xi-Ping; Setola, Vincent; Yadav, Prem N.; Allen, John A.; Rogan, Sarah C.; Hanson, Bonnie J.; Revankar, Chetana; Robers, Matt; Doucette, Chris; Roth, Bryan L.

Molecular Pharmacology, 2009 , vol. 76, # 4 p. 710 - 722 Title/Abstract Full Text View citing articles Show Details

Zhou, Shu-Feng; Liu, Jun-Ping; Lai, Xin-Sheng

Current Medicinal Chemistry, 2009 , vol. 16, # 21 p. 2661 - 2805 Title/Abstract Full Text View citing articles Show Details

Miller, Keith J.; Wu, Ginger Y.; Varnes, Jeffrey G.; Levesque, Paul; Li, Julia; Li, Danshi; Robl, Jeffrey A.; Rossi, Karen A.; Wacker, Dean A.

Molecular Pharmacology, 2009 , vol. 76, # 6 p. 1211 - 1219 Title/Abstract Full Text View citing articles Show Details

Rosse, Gerard; Schaffhauser, Herve

Current Topics in Medicinal Chemistry, 2010 , vol. 10, # 2 p. 207 - 221 Title/Abstract Full Text View citing articles Show Details

Volk, Balazs; Nagy, Bence J.; Vas, Szilvia; Kostyalik, Diana; Simig, Gyula; Bagdy, Gyoergy

Current Topics in Medicinal Chemistry, 2010 , vol. 10, # 5 p. 554 - 578

Title/Abstract Full Text View citing articles Show Details

Hanna-Elias; Manallack; Berque-Bestel; Irving; Coupar; Iskander

Current Medicinal Chemistry, 2010 , vol. 17, # 25 p. 2775 - 2787 Title/Abstract Full Text View citing articles Show Details

Beckers, Daniel P.; Goldstin, Bella; Gullikson, Gary W.; Loeffler, Richard; Moormann, Alan; Moummi, Chaffiq; Nosal, Roger; Spangler, Dale; Villamil, Clara I.; Yang, Dai-C.; Zabrowski, Daniel L; Flynn, Daniel L.

Pharmacochemistry Library, 1996 , vol. 24, # C p. 99 - 120 Title/Abstract Full Text View citing articles Show Details

Klein, Michael T.; Dukat, Malgorzata; Glennon, Richard A.; Teitler, Milt

Journal of Pharmacology and Experimental Therapeutics, 2011 , vol. 337, # 3 p. 860 - 867 Title/Abstract Full Text View citing articles Show Details

Zhu, Hai-Liang; Ling, Jun-Bing; Xu, Peng-Fei

Journal of Organic Chemistry, 2012 , vol. 77, # 17 p. 7737 - 7743 Title/Abstract Full Text View citing articles Show Details

Wei, Yuhui; Xi, Lili; Yao, Xiaojun; Li, Jiazhong; Wu, Xinan

Archiv der Pharmazie, 2012 , vol. 345, # 10 p. 759 - 766 Title/Abstract Full Text View citing articles Show Details

Hayama, Tadashi; Sakaguchi, Yohei; Yoshida, Hideyuki; Itoyama, Miki; Todoroki, Kenichiro; Yamaguchi, Masatoshi; Nohta, Hitoshi

Analytical Chemistry, 2012 , vol. 84, # 19 p. 8407 - 8414 Title/Abstract Full Text View citing articles Show Details

Peshkov, Vsevolod A.; Pereshivko, Olga P.; Der Eycken, Erik V. Van

Advanced Synthesis and Catalysis, 2012 , vol. 354, # 14-15 p. 2841 - 2848 Title/Abstract Full Text View citing articles Show Details

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Engel-Andreasen, Jens; Shimpukade, Bharat; Ulven, Trond

Green Chemistry, 2013 , vol. 15, # 2 p. 336 - 340 Title/Abstract Full Text View citing articles Show Details

Chemilia AB; Högberg, Marita; Johansson, Tommy; Dahlstedt, Emma; Smitt, Olof

Patent: EP2502924 A1, 2012 ; Title/Abstract Full Text Show Details

Pharma Mar, S.A.; Martín López, Ma Jesús; Francesch Solloso, Andrés; Cuevas Marchante, Maria del Carmen

Patent: US2013/66067 A1, 2013 ; Title/Abstract Full Text Show Details

Eschenbrenner-Lux, Vincent; Dückert, Heiko; Khedkar, Vivek; Bruss, Hanna; Waldmann, Herbert; Kumar, Kamal

Chemistry - A European Journal, 2013 , vol. 19, # 7 p. 2294 - 2304 Title/Abstract Full Text View citing articles Show Details

Hong, Bor-Cherng; Liao, Wei-Kai; Dange, Nitin S.; Liao, Ju-Hsiou

Organic Letters, 2013 , vol. 15, # 3 p. 468 - 471 Title/Abstract Full Text View citing articles Show Details

INTELLECT NEUROSCIENCES, INC.; CHAIN, Daniel, G.

Patent: WO2013/63086 A1, 2013 ; Title/Abstract Full Text Show Details

20 of 239

Comment (Pharmacological Data)

Bioactivities present

Reference

NATREON, INC.; Ghosal, Shibnath; Veeraragavan, Muruganandam; Kalidindi, Sanyasi R.

Patent: US2013/115316 A1, 2013 ; Title/Abstract Full Text Show Details

Sun, Jing; Zhang, Li-Li; Yan, Chao-Guo

Tetrahedron, 2013 , vol. 69, # 26 p. 5451 - 5459 Title/Abstract Full Text View citing articles Show Details

Desroses, Matthieu; Koolmeister, Tobias; Jacques, Sylvain; Llona-Minguez, Sabin; Jacques-Cordonnier, Marie-Caroline; Cazares-Koerner, Armando; Helleday, Thomas; Scobie, Martin

Tetrahedron Letters, 2013 , vol. 54, # 27 p. 3554 - 3557 Title/Abstract Full Text View citing articles Show Details

Klochkov; Afanas'Eva; Bulychev, Yu. N.; Neganova; Shevtsova

Russian Chemical Bulletin, 2012 , vol. 61, # 2 p. 409 - 415 Title/Abstract Full Text View citing articles Show Details

Yin, Qin; Wang, Shou-Guo; You, Shu-Li

Organic Letters, 2013 , vol. 15, # 11 p. 2688 - 2691 Title/Abstract Full Text View citing articles Show Details

Aillaud, Isabelle; Barber, David M.; Thompson, Amber L.; Dixon, Darren J.

Organic Letters, 2013 , vol. 15, # 12 p. 2946 - 2949 Title/Abstract Full Text View citing articles Show Details

Taborsky; Delvigs; Page; Crawford

Journal of medicinal chemistry, 1965 , vol. 8, # 4 p. 60 - 66 Title/Abstract Full Text View citing articles Show Details

Daly; Creveling; Witkop

Journal of medicinal chemistry, 1966 , vol. 9, # 3 p. 273 - 280 Title/Abstract Full Text Show Details

De Bruyn, Tom; Van Westen, Gerard J.P.; IJzerman, Adriaan P.; Stieger, Bruno; De Witte, Peter; Augustijns, Patrick F.; Annaert, Pieter P.

Molecular Pharmacology, 2013 , vol. 83, # 6 p. 1257 - 1267 Title/Abstract Full Text View citing articles Show Details

Bennett Jr; Snyder

Molecular Pharmacology, 1976 , vol. 12, # 3 p. 373 - 389 Title/Abstract Full Text View citing articles Show Details

Davidson; Weidley

Life Sciences, 1976 , vol. 18, # 11 p. 1279 - 1284 Title/Abstract Full Text Show Details

Creese; Snyder

European journal of pharmacology, 1978 , vol. 49, # 2 p. 201 - 202 Title/Abstract Full Text Show Details

UNIVERSITY OF CALCUTTA; COUNCIL OF SCIENTIFIC and INDUSTRIAL RESEARCH; Bandyopadhyay, Uday; Pal, Chinmay; Bindu, Samik; Adhikari, Susanta Sekhar

Patent: US2013/197052 A1, 2013 ; Title/Abstract Full Text Show Details

ChemMedChem, 2013 , vol. 8, # 3 p. 484 - 496 Title/Abstract Full Text View citing articles Show Details

Bockaert; Claeysen; Compan; Dumuis

Current drug targets. CNS and neurological disorders, 2004 , vol. 3, # 1 p. 39 - 51 Title/Abstract Full Text Show Details

Woolley, Marie L; Marsden, Charles A; Fone, Kevin C F

Current drug targets. CNS and neurological disorders, 2004 , vol. 3, # 1 p. 59 - 79 Title/Abstract Full Text Show Details

Zhu, Yan-Ping; Liu, Mei-Cai; Cai, Qun; Jia, Feng-Cheng; Wu, An-Xin

Chemistry - A European Journal, 2013 , vol. 19, # 31 p. 10132 - 10137 Title/Abstract Full Text View citing articles Show Details

Alebouyeh, Mahmoud; Takeda, Michio; Onozato, Maristela Lika; Tojo, Akihiro; Noshiro, Rie; Hasannejad, Habib; Inatomi, Jun; Narikawa, Shinichi; Huang, Xiu-Lin; Khamdang, Suparat; Anzai, Naohiko; Endou, Hitoshi

Journal of Pharmacological Sciences, 2003 , vol. 93, # 4 p. 430 - 436 Title/Abstract Full Text View citing articles Show Details

Leopoldo

Current Medicinal Chemistry, 2004 , vol. 11, # 5 p. 629 - 661 Title/Abstract Full Text View citing articles Show Details

Claeysen, Sylvie; Joubert, Lara; Sebben, Michele; Bockaert, Joel; Dumuis, Aline

The Journal of biological chemistry, 2003 , vol. 278, # 2 p. 699 - 702 Title/Abstract Full Text Show Details

Show next 20

21 of 239

Hide facts Comment (Pharmacological Data)

Bioactivities present

Reference

Ebersole, Barbara J.; Weinstein, Harel; Sealfon, Stuart C.

Journal of Biological Chemistry, 2002 , vol. 277, # 39 p. 36577 - 36584 Title/Abstract Full Text View citing articles Show Details

Teitler, Milt; Herrick-Davis, Katharine; Purohit, Anil

Current topics in medicinal chemistry, 2002 , vol. 2, # 6 p. 529 - 538 Title/Abstract Full Text View citing articles Show Details

Glennon, Richard A; Metwally, Kamel; Dukat, Malgorzata; Ismaiel, Abd M; De los Angeles, Joseph; Herndon, Jeffery; Teitler, Milt; Khorana, Nantaka

Current topics in medicinal chemistry, 2002 , vol. 2, # 6 p. 539 - 558 Title/Abstract Full Text View citing articles Show Details

Berger, Michael L

Neuroscience Letters, 2000 , vol. 296, # 1 p. 29 - 32 Title/Abstract Full Text View citing articles Show Details

Prins; Van Haselen; Lefebvre; Briejer; Akkermans; Schuurkes

British Journal of Pharmacology, 1999 , vol. 127, # 6 p. 1431 - 1437 Title/Abstract Full Text View citing articles Show Details

Prabhakar; Kumar, N. Vasanth; Reddy, M. Ravikanth; Sarma; Reddy, G. Om

Organic Process Research and Development, 1999 , vol. 3, # 3 p. 155 - 160 Title/Abstract Full Text View citing articles Show Details

Rubenstein, Lester A.; Lanzara, Richard G.

Journal of Molecular Structure: THEOCHEM, 1998 , vol. 430, # 1-3 p. 57 - 71 Title/Abstract Full Text View citing articles Show Details

Adham, Nika; Zgombick, John M.; Bard, Jonathan; Branchek, Theresa A.

Journal of Pharmacology and Experimental Therapeutics, 1998 , vol. 287, # 2 p. 508 - 514 Title/Abstract Full Text View citing articles Show Details

Hemedah; Coupar; Mitchelson

British Journal of Pharmacology, 1999 , vol. 126, # 1 p. 179 - 188 Title/Abstract Full Text Show Details

Boess, Frank G.; Monsma Jr., Frederick J.; Sleight, Andrew J.

Journal of Neurochemistry, 1998 , vol. 71, # 5 p. 2169 - 2177 Title/Abstract Full Text View citing articles Show Details

De Vries, Peter; Villalon, Carlos M.; Heiligers, Jan P. C.; Saxena, Pramod R.

Naunyn-Schmiedeberg's Archives of Pharmacology, 1997 , vol. 356, # 1 p. 90 - 99 Title/Abstract Full Text View citing articles Show Details

Pregenzer, Jeffrey F.; Alberts, Glen L.; Bock, Jeffrey H.; Slightom, Jerry L.; Bin Im, Wha

Neuroscience Letters, 1997 , vol. 235, # 3 p. 117 - 120 Title/Abstract Full Text View citing articles Show Details

Kaumann; Sanders; Brown; Murray

Naunyn-Schmiedeberg's archives of pharmacology, 1991 , vol. 344, # 2 p. 150 - 159 Title/Abstract Full Text Show Details

Blondel, Olivier; Gastineau, Monique; Dahmoune, Yamina; Langlois, Michel; Fischmeister, Rodolphe

Journal of Neurochemistry, 1998 , vol. 70, # 6 p. 2252 - 2261 Title/Abstract Full Text View citing articles Show Details

Terron, Jose A.

British Journal of Pharmacology, 1997 , vol. 121, # 3 p. 563 - 571 Title/Abstract Full Text View citing articles Show Details

Adham; Gerald; Schechter; Vaysse; Weinshank; Branchek

European journal of pharmacology, 1996 , vol. 304, # 1-3 p. 231 - 235 Title/Abstract Full Text Show Details

Parker, Eric M.; Izzarelli, Darcy G.; Lewis-Higgins, Lore; Palmer, Dawn; Shapiro, Robert A.

Journal of Neurochemistry, 1996 , vol. 67, # 5 p. 2096 - 2103

Title/Abstract Full Text View citing articles Show Details

Leung; Pulido-Rios; Bonhaus; Pekins; Zeitung; Hsu; Clark; Wong; Eglen

Naunyn-Schmiedeberg's archives of pharmacology, 1996 , vol. 354, # 2 p. 145 - 156 Title/Abstract Full Text Show Details

Leung; Walsh; Pulido-Rios; Eglen

British Journal of Pharmacology, 1996 , vol. 117, # 5 p. 926 - 930 Title/Abstract Full Text View citing articles Show Details

Budhoo; Harris; Kellum

European Journal of Pharmacology, 1996 , vol. 298, # 2 p. 137 - 144 Title/Abstract Full Text Show Details

22 of 239

23 of 239

Comment (Pharmacological Data)

Bioactivities present

Reference

Pang; Tang; Song; Brown

Life Sciences, 1996 , vol. 58, # 13 p. 1047 - 1057 Title/Abstract Full Text Show Details

Sebben; Ansanay; Bockaert; Dumuis

NeuroReport, 1994 , vol. 5, # 18 p. 2553 - 2557 Title/Abstract Full Text Show Details

Pauwels; Colpaert

Biochemical Pharmacology, 1995 , vol. 50, # 10 p. 1651 - 1658 Title/Abstract Full Text Show Details

Waeber; Sebben; Grossman; Javoy-Agid; Bockaert; Dumuis

Neuroreport, 1993 , vol. 4, # 11 p. 1239 - 1242 Title/Abstract Full Text Show Details

Sugden; Chong; Lewis

British Journal of Pharmacology, 1995 , vol. 114, # 3 p. 618 - 623 Title/Abstract Full Text View citing articles Show Details

Pan; Galligan

European Journal of Pharmacology, 1995 , vol. 278, # 1 p. 67 - 74 Title/Abstract Full Text Show Details

To; Bonhaus; Eglen; Jakeman

British Journal of Pharmacology, 1995 , vol. 115, # 1 p. 107 - 116 Title/Abstract Full Text View citing articles Show Details

Johnson, Michael P.; Loncharich, Richard J.; Baez, Melvyn; Nelson, David L.

Molecular Pharmacology, 1994 , vol. 45, # 2 p. 277 - 286 Title/Abstract Full Text View citing articles Show Details

Gale; Grossman; Whitehead; Oxford; Bunce; Humphrey

British Journal of Pharmacology, 1994 , vol. 111, # 1 p. 332 - 338 Title/Abstract Full Text View citing articles Show Details

Schmuck; Ullmer; Engels; Lubbert

FEBS Letters, 1994 , vol. 342, # 1 p. 85 - 90 Title/Abstract Full Text Show Details

Schiavi; Brunet; Rizzi; Ladinsky

Neuropharmacology, 1994 , vol. 33, # 3-4 p. 543 - 549 Title/Abstract Full Text Show Details

Lee; Ueno; Sunagane; Sun

American Journal of Physiology - Heart and Circulatory Physiology, 1994 , vol. 266, # 3 35-3 p. H1000-H1006 Title/Abstract Full Text View citing articles Show Details

Schoeffter; Waeber

Naunyn-Schmiedeberg's Archives of Pharmacology, 1994 , vol. 350, # 4 p. 356 - 360 Title/Abstract Full Text Show Details

Wardle; Sanger

British Journal of Pharmacology, 1993 , vol. 110, # 4 p. 1593 - 1599 Title/Abstract Full Text View citing articles Show Details

Shen; Monsma Jr.; Metcalf; Jose; Hamblin; Sibley

Journal of Biological Chemistry, 1993 , vol. 268, # 24 p. 18200 - 18204 Title/Abstract Full Text Show Details

Bard; Zgombick; Adham; Vaysse; Branchek; Weinshank

Journal of Biological Chemistry, 1993 , vol. 268, # 31 p. 23422 - 23426 Title/Abstract Full Text Show Details

Ruat; Traiffort; Leurs; Tardivel-Lacombe; Diaz; Arrang -; Schwartz

Proceedings of the National Academy of Sciences of the United States of America, 1993 , vol. 90, # 18 p. 8547 - 8551 Title/Abstract Full Text Show Details

Becker; Gettys; Middleton; Olsen; Albers; Lee -; Fanburg; Raymond

Molecular Pharmacology, 1992 , vol. 42, # 5 p. 817 - 825 Title/Abstract Full Text Show Details

Zgombick; Schechter; Macchi; Hartig; Branchek; Weinshank

Molecular Pharmacology, 1992 , vol. 42, # 2 p. 180 - 185 Title/Abstract Full Text Show Details

Adham; Kao; Schechter; Bard; Olsen; Urquhart; Durkin; Hartig; Weinshank; Branchek

Proceedings of the National Academy of Sciences of the United States of America, 1993 , vol. 90, # 2 p. 408 - 412 Title/Abstract Full Text Show Details

Comment (Pharmacological Data)

Bioactivities present

Reference

Eglen; Alvarez; Johnson; Leung; Wong

British Journal of Pharmacology, 1993 , vol. 108, # 2 p. 376 - 382 Title/Abstract Full Text View citing articles Show Details

Monsma Jr.; Shen; Ward; Hamblin; Sibley

Molecular Pharmacology, 1993 , vol. 43, # 3 p. 320 - 327 Title/Abstract Full Text Show Details

Wainscott; Cohen; Schenck; Audia; Nissen; Baez; Kursar; Lucaites; Nelson

Molecular Pharmacology, 1993 , vol. 43, # 3 p. 419 - 426 Title/Abstract Full Text Show Details

Sweetnam; Caldwell; Lancaster; Bauer Jnr.; McMillan; Kinnier; Price

Journal of Natural Products (Lloydia), 1993 , vol. 56, # 4 p. 441 - 455 Title/Abstract Full Text Show Details

Foguet; Hoyer; Pardo; Parekh; Kluxen; Kalkman; Stuhmer; Lubbert

EMBO Journal, 1992 , vol. 11, # 9 p. 3481 - 3487 Title/Abstract Full Text Show Details

Eison; Wright; Freeman

Life sciences, 1992 , vol. 51, # 10 p. PL95-99 Title/Abstract Full Text Show Details

Rhodes; Colemann; Lattimer

Naunyn-Schmiedeberg's Archives of Pharmacology, 1992 , vol. 346, # 5 p. 496 - 503 Title/Abstract Full Text Show Details

Mourey; Dawson; Barrow; Enna; Snyder

Molecular pharmacology, 1992 , vol. 42, # 4 p. 619 - 626 Title/Abstract Full Text Show Details

Hamblin; Metcalf; McGuffin; Karpells

Biochemical and Biophysical Research Communications, 1992 , vol. 184, # 2 p. 752 - 759 Title/Abstract Full Text Show Details

Zgombick; Weinshank; Macchi; Schechter; Branchek; Hartig

Molecular Pharmacology, 1991 , vol. 40, # 6 p. 1036 - 1042 Title/Abstract Full Text Show Details

Schiavone; Giraldo; Giudici; Turconi; Sagrada

Life Sciences, 1992 , vol. 51, # 8 p. 583 - 592 Title/Abstract Full Text Show Details

Weinshank; Zgombick; Macchi; Branchek; Hartig

Proceedings of the National Academy of Sciences of the United States of America, 1992 , vol. 89, # 8 p. 3630 - 3634 Title/Abstract Full Text Show Details

Baines; Downer

Archives of insect biochemistry and physiology, 1991 , vol. 16, # 3 p. 153 - 163 Title/Abstract Full Text View citing articles Show Details

Hamblin; Metcalf

Molecular Pharmacology, 1991 , vol. 40, # 2 p. 143 - 148 Title/Abstract Full Text Show Details

Boulenguez; Chauveau; Segu; Morel; Lanoir; Delaage

European Journal of Pharmacology, 1991 , vol. 194, # 1 p. 91 - 98 Title/Abstract Full Text Show Details

Stankov; Cozzi; Lucini; Fumagalli; Scaglione; Fraschini

Neuroendocrinology, 1991 , vol. 53, # 3 p. 214 - 221 Title/Abstract Full Text Show Details

Glennon; Ismaiel; Chaurasia; Titeler

Drug Development Research, 1991 , vol. 22, # 1 p. 25 - 36 Title/Abstract Full Text View citing articles Show Details

Elswood; Bunce; Humphrey

European Journal of Pharmacology, 1991 , vol. 196, # 2 p. 149 - 155 Title/Abstract Full Text Show Details

Villalon; Den Boer; Heiligers; Saxena

British Journal of Pharmacology, 1991 , vol. 102, # 1 p. 107 - 112 Title/Abstract Full Text View citing articles Show Details

Eglen; Swank; Walsh; Whiting

British journal of pharmacology, 1990 , vol. 101, # 3 p. 513 - 520 Title/Abstract Full Text Show Details

24 of 239

Comment (Pharmacological Data)

Bioactivities present

Reference

Sharif; Wong; Loury; Stefanich; Michel; Eglen; Whiting

British journal of pharmacology, 1991 , vol. 102, # 4 p. 919 - 925 Title/Abstract Full Text Show Details

Baxter; Craig; Clarke

Naunyn-Schmiedeberg's archives of pharmacology, 1991 , vol. 343, # 5 p. 439 - 446 Title/Abstract Full Text Show Details

Ivins; Molinoff

Molecular Pharmacology, 1990 , vol. 37, # 5 p. 622 - 630 Title/Abstract Full Text View citing articles Show Details

Lewis; Arendt; English

Journal of Pharmacology and Experimental Therapeutics, 1990 , vol. 252, # 1 p. 370 - 373 Title/Abstract Full Text View citing articles Show Details

Craig; Clarke

Journal of Pharmacology and Experimental Therapeutics, 1990 , vol. 252, # 3 p. 1378 - 1386 Title/Abstract Full Text View citing articles Show Details

Glennon; Chaurasia; Titeler

Journal of Medicinal Chemistry, 1990 , vol. 33, # 10 p. 2777 - 2784 Title/Abstract Full Text Show Details

Waeber; Schoeffter; Hoyer; Palacios

Neurochemical research, 1990 , vol. 15, # 6 p. 567 - 582 Title/Abstract Full Text Show Details

Dumuis; Bouhelal; Sebben; Cory; Bockaert

Molecular Pharmacology, 1988 , vol. 34, # 6 p. 880 - 887 Title/Abstract Full Text View citing articles Show Details

Glennon; Naiman; Pierson; Smith; Ismaiel; Titeler; Lyon

Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1921 - 1926 Title/Abstract Full Text View citing articles Show Details

Dubocovich; Shankar; Mickel

European journal of pharmacology, 1989 , vol. 162, # 2 p. 289 - 299

Title/Abstract Full Text Show Details

Hoyer; Waeber; Schoeffter; Palacios; Dravid

Naunyn-Schmiedeberg's archives of pharmacology, 1989 , vol. 339, # 3 p. 252 - 258 Title/Abstract Full Text Show Details

Taylor; Nikam; Weck; Martin; Nelson

Life Sciences, 1987 , vol. 41, # 16 p. 1961 - 1969 Title/Abstract Full Text Show Details

Lyon; Titeler; Seggel; Glennon

European Journal of Pharmacology, 1988 , vol. 145, # 3 p. 291 - 297 Title/Abstract Full Text Show Details

Herrick-Davis; Titeler; Leonhardt; Struble; Price

Journal of neurochemistry, 1988 , vol. 51, # 6 p. 1906 - 1912 Title/Abstract Full Text Show Details

Hoyer; Neijt

Molecular Pharmacology, 1988 , vol. 33, # 3 p. 303 - 309 Title/Abstract Full Text View citing articles Show Details

Herrick-Davis; Titeler

Journal of Neurochemistry, 1988 , vol. 50, # 5 p. 1624 - 1631 Title/Abstract Full Text View citing articles Show Details

Hoyer

Trends in Pharmacological Sciences, 1988 , vol. 9, # 3 p. 89 - 94 Title/Abstract Full Text Show Details

Waeber; Schoeffter; Palacios; Hoyer

Naunyn-Schmiedeberg's Archives of Pharmacology, 1988 , vol. 337, # 6 p. 595 - 601 Title/Abstract Full Text Show Details

Duncan; Takahashi; Dubocovich

Endocrinology, 1988 , vol. 122, # 5 p. 1825 - 1833 Title/Abstract Full Text Show Details

Glennon

Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 1 - 12 Title/Abstract Full Text Show Details

25 of 239

Comment (Pharmacological Data)

Bioactivities present

Reference

Heuring; Peroutka

The Journal of neuroscience : the official journal of the Society for Neuroscience, 1987 , vol. 7, # 3 p. 894 - 903 Title/Abstract Full Text Show Details

Hoyer; Vos; Closse; Pazos; Palacios; Davies

Naunyn-Schmiedeberg's archives of pharmacology, 1987 , vol. 335, # 3 p. 226 - 230 Title/Abstract Full Text Show Details

Dubocovich; Takahashi

Proceedings of the National Academy of Sciences of the United States of America, 1987 , vol. 84, # 11 p. 3916 - 3920 Title/Abstract Full Text Show Details

Lyon; Davis; Titeler

Molecular pharmacology, 1987 , vol. 31, # 2 p. 194 - 199 Title/Abstract Full Text Show Details

Schlegel; Peroutka

Biochemical Pharmacology, 1986 , vol. 35, # 12 p. 1943 - 1949 Title/Abstract Full Text Show Details

Peroutka

Journal of Neurochemistry, 1986 , vol. 47, # 2 p. 529 - 540 Title/Abstract Full Text View citing articles Show Details

Hoyer; Engel; Kalkman

European journal of pharmacology, 1985 , vol. 118, # 1-2 p. 1 - 12 Title/Abstract Full Text Show Details

Hall; el Mestikawy; Emerit; Pichat; Hamon; Gozlan

Journal of neurochemistry, 1985 , vol. 44, # 6 p. 1685 - 1696 Title/Abstract Full Text Show Details

Clancy; Maayani

Journal of Pharmacology and Experimental Therapeutics, 1985 , vol. 233, # 3 p. 761 - 769 Title/Abstract Full Text View citing articles Show Details

Branchek; Kates; Gershon

Brain Research, 1984 , vol. 324, # 1 p. 107 - 118 Title/Abstract Full Text Show Details

Dubocovich

Journal of Pharmacology and Experimental Therapeutics, 1985 , vol. 234, # 2 p. 395 - 401 Title/Abstract Full Text View citing articles Show Details

Gozlan; El Mestikawy; Pichat; Glowinski; Hamon

Nature, 1983 , vol. 305, # 5930 p. 140 - 142 Title/Abstract Full Text Show Details

Cascio; Kellar

European journal of pharmacology, 1983 , vol. 95, # 1-2 p. 31 - 39 Title/Abstract Full Text Show Details

Leysen; Gommeren; De Clerck

European journal of pharmacology, 1983 , vol. 88, # 1 p. 125 - 130 Title/Abstract Full Text Show Details

Weiss; Drummond

Molecular Pharmacology, 1981 , vol. 20, # 3 p. 592 - 597 Title/Abstract Full Text View citing articles Show Details

Liu, Song; Scotti, John S.; Kozmin, Sergey A.

Journal of Organic Chemistry, 2013 , vol. 78, # 17 p. 8645 - 8654 Title/Abstract Full Text View citing articles Show Details

Gregory, Alex W.; Jakubec, Pavol; Turner, Paul; Dixon, Darren J.

Organic Letters, 2013 , vol. 15, # 17 p. 4330 - 4333 Title/Abstract Full Text View citing articles Show Details

Kellar; Cascio

European journal of pharmacology, 1982 , vol. 78, # 4 p. 475 - 478 Title/Abstract Full Text Show Details

Leysen; Niemegeers; Van Nueten; Laduron

Molecular pharmacology, 1982 , vol. 21, # 2 p. 301 - 314 Title/Abstract Full Text Show Details

Middlemiss; Carroll; Fisher; Mounsey

European journal of pharmacology, 1980 , vol. 66, # 2-3 p. 253 - 254 Title/Abstract Full Text Show Details

26 of 239

Comment (Pharmacological Data)

Bioactivities present

Reference

Peroutka; Snyder

Molecular Pharmacology, 1979 , vol. 16, # 3 p. 687 - 699 Title/Abstract Full Text View citing articles Show Details

Peroutka; Lebovitz; Snyder

Molecular Pharmacology, 1979 , vol. 16, # 3 p. 700 - 708 Title/Abstract Full Text View citing articles Show Details

Hwang; Van Woert

Journal of Pharmacology and Experimental Therapeutics, 1980 , vol. 213, # 2 p. 254 - 260 Title/Abstract Full Text View citing articles Show Details

Creese; Prosser; Snyder

Life Sciences, 1978 , vol. 23, # 5 p. 495 - 499 Title/Abstract Full Text Show Details

Northup; Mansour

Molecular Pharmacology, 1978 , vol. 14, # 5 p. 804 - 819 Title/Abstract Full Text View citing articles Show Details

Horn

Journal of Neurochemistry, 1973 , vol. 21, # 4 p. 883 - 888 Title/Abstract Full Text Show Details

Mellini, Paolo; Kokkola, Tarja; Suuronen, Tiina; Salo, Heikki S.; Tolvanen, Laura; Mai, Antonello; Lahtela-Kakkonen, Maija; Jarho, Elina M.

Journal of Medicinal Chemistry, 2013 , vol. 56, # 17 p. 6681 - 6695 Title/Abstract Full Text View citing articles Show Details

Aziz, Jessy; Brion, Jean-Daniel; Hamze, Abdallah; Alami, Mouad

Advanced Synthesis and Catalysis, 2013 , vol. 355, # 11-12 p. 2417 - 2429 Title/Abstract Full Text View citing articles Show Details

Wei, Qiang; Wang, Ya-Yi; Du, Yu-Liu; Gong, Liu-Zhu

Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 1559 - 1564 Title/Abstract Full Text View citing articles Show Details

Zhang, Di-Han; Tang, Xiang-Ying; Wei, Yin; Shi, Min

Chemistry - A European Journal, 2013 , vol. 19, # 41 p. 13668 - 13673 Title/Abstract Full Text View citing articles Show Details

Ionescu, Alexandra; Cornut, Damien; Soriano, Sebastien; Guissart, Celine; Van Antwerpen, Pierre; Jabin, Ivan

Tetrahedron Letters, 2013 , vol. 54, # 45 p. 6087 - 6089 Title/Abstract Full Text View citing articles Show Details

Li, Zeng; Li, Jing; Yang, Nan; Chen, Ying; Zhou, Yu; Ji, Xun; Zhang, Lei; Wang, Jinfang; Xie, Xin; Liu, Hong

Journal of Organic Chemistry, 2013 , vol. 78, # 21 p. 10802 - 10811 Title/Abstract Full Text View citing articles Show Details

Baxter, Gordon Smith; Borman, Richard Anthony.

Patent: WO2001/8668 A2, 2001 ; Title/Abstract Full Text Show Details

Campbell, A. K.; Siddle, K.

Biochim. Biophys. Acta (G) [1963-], 1977 , vol. 497, # 1 p. 62 - 74 Title/Abstract Full Text Show Details

Gerald, Christophe; Hartig, Paul R.; Branchek, Theresa; Weinshank, Richard L.

Patent: US5766879 , 1998 ; Title/Abstract Full Text Show Details

Bard, Jonathan A.; Branchek, Theresa; Weinshank, Richard L.

Patent: US2003/166066 A1, 2003 ; Title/Abstract Full Text Show Details

Sibley, David R.; Monsma, Frederick J.; Hamblin, Mark

Patent: US2002/91235 A1, 2002 ; Title/Abstract Full Text Show Details

Weinshank; Richard L.; Branchek; Theresa; Hartig; Paul R.

Patent: US6475746 , 2002 ; Title/Abstract Full Text Show Details

Weinshank; Richard L.; Branchek; Theresa; Hartig; Paul R.

Patent: US6406859 , 2002 ; Title/Abstract Full Text Show Details

BISWAL, Shyam; SINGH, Anju; MALHOTRA, Deepti

Patent: WO2008/124660 A2, 2008 ; Title/Abstract Full Text Show Details

27 of 239

Comment (Pharmacological Data)

Bioactivities present

Reference

Borman, Richard Anthony; Tilford, Nicholas Sean; Baxter, Gordon Smith.

Patent: WO2002/56010 , 2002 ; Title/Abstract Full Text Show Details

Blond, Aurelie; Dockerty, Paul; Alvarez, Raquel; Turcaud, Serge; Lecourt, Thomas; Micouin, Laurent

Journal of Organic Chemistry, 2013 , vol. 78, # 23 p. 12236 - 12242 Title/Abstract Full Text View citing articles Show Details

Liu, Yong; Wang, Qun; Zhang, Ying; Huang, Jianbiao; Nie, Linlin; Chen, Jie; Cao, Weiguo; Wu, Xiaoyu

Journal of Organic Chemistry, 2013 , vol. 78, # 23 p. 12009 - 12017 Title/Abstract Full Text View citing articles Show Details

Kuo, Ping-Chung; Li, Yue-Chiun; Hwang, Tsong-Long; Ma, Guo-Hao; Yang, Mei-Lin; Lee, E-Jian; Wu, Tian-Shung

Tetrahedron Letters, 2014 , vol. 55, # 1 p. 108 - 110 Title/Abstract Full Text View citing articles Show Details

Beasley, Benjamin O.; Alli-Balogun, Abimbola; Clarkson, Guy J.; Shipman, Michael

Tetrahedron Letters, 2014 , vol. 55, # 2 p. 541 - 543 Title/Abstract Full Text View citing articles Show Details

Winter, Evelyn; Lecerf-Schmidt, Florine; Gozzi, Gustavo; Peres, Basile; Lightbody, Mark; Gauthier, Charlotte; Ozvegy-Laczka, Csilla; Szakacs, Gergely; Sarkadi, Balazs; Creczynski-Pasa, Tainia B.; Boumendjel, Ahcene; Di Pietro, Attilio

Journal of Medicinal Chemistry, 2013 , vol. 56, # 24 p. 9849 - 9860 Title/Abstract Full Text View citing articles Show Details

TABORSKY; MCISAAC

Journal of medicinal chemistry, 1964 , vol. 7, p. 135 - 141 Title/Abstract Full Text View citing articles Show Details

Cathy D.Mahle; Katherine S.Takaki; A. John Watson

Annual reports in medicinal chemistry, 1997 , vol. 32, p. 31 - 40 Title/Abstract Full Text Show Details

J. E. Leysen; J. P. Tollenaere

Annual reports in medicinal chemistry, 1982 , vol. 17, p. 1 - 10 Title/Abstract Full Text Show Details

ROBERT G. TABORSKY; PETER DELVIGS; DJURO PALAIC; MERLIN BUMPUS

Journal of medicinal chemistry, 1967 , vol. 10, # 3 p. 403 - 407 Title/Abstract Full Text Show Details

BORMAN Richard Anthony; TILFORD Nicholas Sean; BAXTER Gordon Smith

Patent: WO2002/56010 A2, 2002 ; Title/Abstract Full Text Show Details

KETTLE, Anthony

Patent: WO2002/90575 A1, 2002 ; Title/Abstract Full Text Show Details

SATYA P. GUPTA; PRITHVI SINGH; MAHESH C. BINDAL

Chemical reviews, 1983 , vol. 83, # 6 p. 633 - 649 Title/Abstract Full Text Show Details

Richard L. Weinshank; Theresa Branchek; Paul R. Hartig

Patent: US5786155 A, 1998 ; Title/Abstract Full Text Show Details

V. A. Anisimova; N. I. Avdyunina; A. A. Spasov; I. A. Barchan

Pharm Chem J, 2002 , vol. 36, # 7 p. 377 - 381 Title/Abstract Full Text Show Details

Jonathan A. Bard; Theresa Branchek; Richard L. Weinshank

Patent: US5985585 A, 1999 ; Title/Abstract Full Text Show Details

Christophe Gerald; Paul R. Hartig; Theresa Branchek; Richard L. Weinshank

Patent: US6331401 B1, 2001 ; Title/Abstract Full Text Show Details

GERALD, Christophe; HARTIG, Paul; BRANCHEK, Theresa, A.; WEINSHANK, Richard, L.

Patent: WO1994/14957 A2, 1994 ; Title/Abstract Full Text Show Details

Anthony Kettle

Patent: US7108997 B2, 2006 ; Title/Abstract Full Text Show Details

Odagaki, Yuji; Kinoshita, Masakazu; Toyoshima, Ryoichi

European Journal of Pharmacology, 2014 , vol. 726, # 1 p. 109 - 115 Title/Abstract Full Text View citing articles Show Details

28 of 239

Comment (Pharmacological Data)

Bioactivities present

Reference

Zhang, Lei; Chang, Lina; Hu, Hongwen; Wang, Huaqin; Yao, Zhu-Jun; Wang, Shaozhong

Chemistry - A European Journal, 2014 , vol. 20, # 10 p. 2925 - 2932 Title/Abstract Full Text View citing articles Show Details

Zimmerman, Sommer S.; Khatri, Alpa; Garnier-Amblard, Ethel C.; Mullasseril, Praseeda; Kurtkaya, Natalie L.; Gyoneva, Stefka; Hansen, Kasper B.; Traynelis, Stephen F.; Liotta, Dennis C.

Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2334 - 2356 Title/Abstract Full Text View citing articles Show Details

Schuck, Desirée C.; Jordão, Alessandro K.; Nakabashi, Myna; Cunha, Anna C.; Ferreira, Vitor F.; Garcia, Célia R.S.

European Journal of Medicinal Chemistry, 2014 , vol. 78, p. 375 - 382 Title/Abstract Full Text View citing articles Show Details

López-Iglesias, Beatriz; Pérez, Concepción; Morales-García, José A.; Alonso-Gil, Sandra; Pérez-Castillo, Ana; Romero, Alejandro; López, Manuela G.; Villarroya, Mercedes; Conde, Santiago; Rodríguez-Franco, María Isabel

Journal of Medicinal Chemistry, 2014 , vol. 57, # 9 p. 3773 - 3785 Title/Abstract Full Text View citing articles Show Details

Ren, Jing; Li, Jian; Wang, Yueqin; Chen, Wuyan; Shen, Aijun; Liu, Hongchun; Chen, Danqi; Cao, Danyan; Li, Yanlian; Zhang, Naixia; Xu, Yechun; Geng, Meiyu; He, Jianhua; Xiong, Bing; Shen, Jingkang

Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 11 p. 2525 - 2529 Title/Abstract Full Text View citing articles Show Details

Nelson, Hosea M.; Reisberg, Solomon H.; Shunatona, Hunter P.; Patel, Jigar S.; Toste, F. Dean

Angewandte Chemie - International Edition, 2014 , vol. 53, # 22 p. 5600 - 5603 Angew. Chem., 2014 , vol. 126, # 22 p. 5706 - 5709,4 Title/Abstract Full Text View citing articles Show Details

Li, Yongzhen; Feng, Tingting; Liu, Peng; Liu, Chang; Wang, Xiao; Li, Dongsheng; Li, Ni; Chen, Minghua; Xu, Yanni; Si, Shuyi

ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 8 p. 884 - 888 Title/Abstract Full Text View citing articles Show Details

Chojnacki, Jeremy E.; Liu, Kai; Yan, Xing; Toldo, Stefano; Selden, Tyler; Estrada, Martin; Rodríguez-Franco, María Isabel; Halquist, Matthew S.; Ye, Dexian; Zhang, Shijun

ACS Chemical Neuroscience, 2014 , vol. 5, # 8 p. 690 - 699 Title/Abstract Full Text View citing articles Show Details

Pathak, Ashish K.; Pathak, Vibha; Reynolds, Robert C.

ACS Combinatorial Science, 2014 , vol. 16, # 9 p. 485 - 493 Title/Abstract Full Text View citing articles Show Details

Blough, Bruce E.; Landavazo, Antonio; Partilla, John S.; Decker, Ann M.; Page, Kevin M.; Baumann, Michael H.; Rothman, Richard B.

Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 19 p. 4754 - 4758 Title/Abstract Full Text View citing articles Show Details

Abd Razik, Basma M.; Osman, Hasnah; Basiri, Alireza; Salhin, Abdussalam; Kia, Yalda; Ezzat, Mohammed Oday; Murugaiyah, Vikneswaran

Bioorganic Chemistry, 2014 , vol. 57, p. 162 - 168 Title/Abstract Full Text View citing articles Show Details

Ruchti, Jonathan; Carreira, Erick M.

Journal of the American Chemical Society, 2014 , vol. 136, # 48 p. 16756 - 16759 Title/Abstract Full Text View citing articles Show Details

Bedos, Philippe; Baltas, Michel

Patent: US2015/31740 A1, 2015 ; Title/Abstract Full Text Show Details

Dempsey, Daniel R.; Jeffries, Kristen A.; Bond, Jason D.; Carpenter, Anne-Marie; Rodriguez-Ospina, Santiago; Breydo, Leonid; Caswell, K. Kenneth; Merkler, David J.

Biochemistry, 2014 , vol. 53, # 49 p. 7777 - 7793 Title/Abstract Full Text View citing articles Show Details

Zhu, Dan; Sun, Jing; Yan, Chao-Guo

RSC Advances, 2014 , vol. 4, # 108 p. 62817 - 62826 Title/Abstract Full Text View citing articles Show Details

Tobisu, Mamoru; Takahira, Tsuyoshi; Ohtsuki, Akimichi; Chatani, Naoto

Organic Letters, 2015 , vol. 17, # 3 p. 680 - 683 Title/Abstract Full Text View citing articles Show Details

Haduch, Anna; Bromek, Ewa; Kot, Marta; Kamińska, Katarzyna; Gołembiowska, Krystyna; Daniel, Wladyslawa A.

Journal of Neurochemistry, 2015 , vol. 133, # 1 p. 83 - 92 Title/Abstract Full Text View citing articles Show Details

Zhao, Hai-Tao; Zhong, Shu-Ming; Qin, Jiang-Ke; Tang, Huang

Journal of the Serbian Chemical Society, 2015 , vol. 80, # 2 p. 127 - 136 Title/Abstract Full Text View citing articles Show Details

Bartolucci, Silvia; Mari, Michele; Bedini, Annalida; Piersanti, Giovanni; Spadoni, Gilberto

Journal of Organic Chemistry, 2015 , vol. 80, # 6 p. 3217 - 3222 Title/Abstract Full Text View citing articles Show Details

Liu, Chuan; Yin, Qin; Dai, Li-Xin; You, Shu-Li

Chemical Communications, 2015 , vol. 51, # 27 p. 5971 - 5974 Title/Abstract Full Text View citing articles Show Details

29 of 239

Comment (Pharmacological Data)

Bioactivities present

Reference

Egea, Javier; Buendia, Izaskun; Parada, Esther; Navarro, Elisa; Rada, Patricia; Cuadrado, Antonio; López, Manuela G.; García, Antonio G.; León, Rafael

British Journal of Pharmacology, 2015 , vol. 172, # 7 p. 1807 - 1821 Title/Abstract Full Text View citing articles Show Details

Danda, Adithi; Kumar, Kamal; Waldmann, Herbert

Chemical Communications, 2015 , vol. 51, # 35 p. 7536 - 7539 Title/Abstract Full Text View citing articles Show Details

Dempsey, Daniel R.; Jeffries, Kristen A.; Handa, Sumit; Carpenter, Anne-Marie; Rodriguez-Ospina, Santiago; Breydo, Leonid; Merkler, David J.

Biochemistry, 2015 , vol. 54, # 16 p. 2644 - 2658 Title/Abstract Full Text View citing articles Show Details

VIRGINIA COMMONWEALTH UNIVERSITY; ZHANG, Shijun

Patent: WO2015/69970 A1, 2015 ; Title/Abstract Full Text Show Details

Haduch, Anna; Bromek, Ewa; Kot, Marta; Kamińska, Katarzyna; Gołembiowska, Krystyna; Daniel, Wladyslawa A.

Journal of neurochemistry, 2015 , vol. 133, # 1 p. 83 - 92 Title/Abstract Full Text Show Details

Kröger, Denis; Brockmeyer, Fabian; Kahrs, Christoph

Organic and Biomolecular Chemistry, 2015 , vol. 13, # 26 p. 7223 - 7229 Title/Abstract Full Text View citing articles Show Details

Zlotos, Darius P.; Riad, Noura M.; Osman, Mai B.; Dodda, Bala R.; Witt-Enderby, Paula A.

MedChemComm, 2015 , vol. 6, # 7 p. 1340 - 1344 Title/Abstract Full Text View citing articles Show Details

Nichols, David E.; Sassano, M. Flori; Halberstadt, Adam L.; Klein, Landon M.; Brandt, Simon D.; Elliott, Simon P.; Fiedler, Wolfgang J.

ACS Chemical Neuroscience, 2015 , vol. 6, # 7 p. 1165 - 1175 Title/Abstract Full Text View citing articles Show Details

Cheng, Shaobing; Zheng, Wei; Gong, Ping; Zhou, Qiang; Xie, Qiong; Yu, Lining; Zhang, Peiyi; Chen, Liangkang; Li, Juan; Chen, Jianxing; Chen, Hailin; Chen, Hongzhuan

Bioorganic and Medicinal Chemistry, 2015 , vol. 23, # 13 art. no. 12307, p. 3110 - 3118

Title/Abstract Full Text View citing articles Show Details

Xu, Wenqing; Wang, Wei; Wang, Xiang

Angewandte Chemie - International Edition, 2015 , vol. 54, # 33 p. 9546 - 9549 Angew. Chem., 2015 , vol. 127, p. 9682 - 9685 Title/Abstract Full Text View citing articles Show Details

Wang, Huifei; Liu, Dong; Chen, Huiyu; Li, Jing; Wang, David Zhigang

Tetrahedron, 2015 , vol. 71, # 38 p. 7073 - 7076 Title/Abstract Full Text View citing articles Show Details

Oda, Shingo; Fujiwara, Ryoichi; Kutsuno, Yuki; Fukami, Tatsuki; Itoh, Tomoo; Yokoi, Tsuyoshi; Nakajima, Miki

Drug Metabolism and Disposition, 2015 , vol. 43, # 6 p. 812 - 818 Title/Abstract Full Text View citing articles Show Details

Wang, Shengzheng; Fang, Kun; Dong, Guoqiang; Chen, Shuqiang; Liu, Na; Miao, Zhenyuan; Yao, Jianzhong; Li, Jian; Zhang, Wannian; Sheng, Chunquan

Journal of Medicinal Chemistry, 2015 , vol. 58, # 16 p. 6678 - 6696 Title/Abstract Full Text View citing articles Show Details

Luo, Xiao-Ting; Wang, Chun-Ming; Liu, Yun; Huang, Zhen-Guang

European Journal of Medicinal Chemistry, 2015 , vol. 103, p. 302 - 311 Title/Abstract Full Text View citing articles Show Details

Eagon, Scott; Anderson, Marc O.

European Journal of Organic Chemistry, 2014 , vol. 2014, # 8 p. 1653 - 1665 Title/Abstract Full Text Show Details

Jaswant S. Gidda; John M. Schaus

Patent: US5576352 A, 1996 ; Title/Abstract Full Text Show Details

Jaswant S. Gidda; John M. Schaus

Patent: US5594034 A, 1997 ; Title/Abstract Full Text Show Details

Gu, Jiaojiao; Jing, Lulu; Ma, Xiaotao; Zhang, Zhaofeng; Guo, Qianying; Li, Yong

Journal of Nutritional Biochemistry, 2015 , vol. 26, # 12 p. 1509 - 1519 Title/Abstract Full Text View citing articles Show Details

PHARMASYNTHESE; LE ROY, Pierre-Yves; LE GUEN, Yves

Patent: US2015/353469 A1, 2015 ; Title/Abstract Full Text Show Details

Sosi, Izidor; Anderluh, Marko; Sova, Matej; Gobec, Martina; Mlinari Raan, Irena; Derouaux, Adeline; Amoroso, Ana; Terrak, Mohammed; Breukink, Eefjan; Gobec, Stanislav

Journal of Medicinal Chemistry, 2015 , vol. 58, # 24 p. 9712 - 9721 Title/Abstract Full Text View citing articles Show Details

30 of 239

Comment (Pharmacological Data)

Bioactivities present

Reference

ELI LILLY AND COMPANY; Chen, Zhaogen; Cohen, Michael Philip; Fisher, Matthew Joseph; Gillig, James Ronald; McCowan, Jefferson Ray; Miller, Shawn Christopher; Schaus, John Mehnert; Giethlen, Bruno

Patent: EP1859798 B1, 2015 ; Title/Abstract Full Text Show Details

WEINSHANK Richard L.; BRANCHEK Theresa; HARTIG Paul R.

Patent: EP530265 B1, 1998 ; Title/Abstract Full Text Show Details

BARD Jonathan A.; WEINSHANK Richard L.; BRANCHEK Theresa

Patent: EP624100 B1, 2000 ; Title/Abstract Full Text Show Details

Theresa Branchek; Paul R. Hartig; Richard L. Weinshank

Patent: US2002/115149 A1, 2002 ; Title/Abstract Full Text Show Details

Richard L. Weinshank; Theresa Brancheck; Paul R. Hartig

Patent: US2003/8823 A1, 2003 ; Title/Abstract Full Text Show Details

Herington, Jennifer L.; Swale, Daniel R.; Brown, Naoko; Shelton, Elaine L.; Choi, Hyehun; Williams, Charles H.; Hong, Charles C.; Paria, Bibhash C.; Denton, Jerod S.; Reese, Jeff

PLoS ONE, 2015 , vol. 10, # 11 art. no. E0143243 Title/Abstract Full Text View citing articles Show Details

Liu, Chuan; Yi, Ji-Cheng; Zheng, Zhong-Bo; Tang, Yong; Dai, Li-Xin; You, Shu-Li

Angewandte Chemie - International Edition, 2016 , vol. 55, # 2 p. 751 - 754 Angew. Chem., 2016 , vol. 128, # 2 p. 761 - 764,4 Title/Abstract Full Text View citing articles Show Details

Tracy, Timothy S.; Chaudhry, Amarjit S.; Prasad, Bhagwat; Thummel, Kenneth E.; Schuetz, Erin G.; Zhong, Xiao-Bo; Tien, Yun-Chen; Jeong, Hyunyoung; Pan, Xian; Shireman, Laura M.; Tay-Sontheimer, Jessica; Lin, Yvonne S.

Drug Metabolism and Disposition, 2016 , vol. 44, # 3 p. 343 - 351 Title/Abstract Full Text View citing articles Show Details

Hényková, Eva; Vránová, Hana Přikrylová; Amakorová, Petra; Pospíšil, Tomáš; Žukauskaite, Asta; Vlčková, Magdaléna; Urbánek, Lubor; Novák, Ondřej; Mareš, Jan; Kaňovský, Petr; Strnad, Miroslav

Journal of Chromatography A, 2016 , vol. 1437, p. 145 - 157 Title/Abstract Full Text View citing articles Show Details

Hough; Segal

Neuroscience, 2016 , vol. 322, p. 178 - 194 Title/Abstract Full Text View citing articles Show Details

Algiert, Barbara; Rotsztejn, Helena; Mucha, Paulina; Trznadel-Grodzka, Ewa

Przeglad Dermatologiczny, 2016 , vol. 103, # 1 p. 71 - 76

Title/Abstract Full Text View citing articles Show Details

Majeed, Zana R.; Abdeljaber, Esraa; Soveland, Robin; Cornwell, Kristin; Bankemper, Aubrey; Koch, Felicitas; Cooper, Robin L.

Neural Plasticity, 2016 , vol. 2016, art. no. 7291438 Title/Abstract Full Text View citing articles Show Details

Hardeland, Rüdiger

Current Pharmaceutical Design, 2016 , vol. 22, # 8 p. 1086 - 1101 Title/Abstract Full Text View citing articles Show Details

Pacini, Nicola; Borziani, Fabio

International Journal of Molecular Sciences, 2016 , vol. 17, # 3 art. no. 341, p. 26 Title/Abstract Full Text View citing articles Show Details

Kirillova, Mariia S.; Muratore, Michael E.; Dorel, Ruth; Echavarren, Antonio M.

Journal of the American Chemical Society, 2016 , vol. 138, # 11 p. 3671 - 3674 Title/Abstract Full Text View citing articles Show Details

Zhao, Fei; Dai, Jiang-Kun; Liu, Dan; Wang, Shi-Jun; Wang, Jun-Ru

Molecules, 2016 , vol. 21, # 3 art. no. 390 Title/Abstract Full Text View citing articles Show Details

Zheng, Nan; Chang, Yuan-Yuan; Zhang, Li-Jie; Gong, Jian-Xian; Yang, Zhen

Chemistry - An Asian Journal, 2016 , vol. 11, # 3 p. 371 - 375 Title/Abstract Full Text View citing articles Show Details

Devaraj; Sollert; Juds; Gates; Pilarski

Chemical Communications, 2016 , vol. 52, # 34 p. 5868 - 5871 Title/Abstract Full Text View citing articles Show Details

Di Mascio, Paolo; Martinez, Glaucia R.; Miyamoto, Sayuri; Ronsein, Graziella E.; Medeiros, Marisa H.G.; Cadet, Jean

Archives of Biochemistry and Biophysics, 2016 , vol. 595, p. 161 - 175 Title/Abstract Full Text View citing articles Show Details

Zhao, Gaoyuan; Xie, Xingang; Sun, Haiyu; Yuan, Ziyun; Zhong, Zhuliang; Tang, Shouchu; She, Xuegong

Organic Letters, 2016 , vol. 18, # 10 p. 2447 - 2450 Title/Abstract Full Text View citing articles Show Details

31 of 239

Comment (Pharmacological Data)

Bioactivities present

Reference

Wilke, Martin; Brand, Christian; Wilke, Josefin; Schmitt, Michael

Physical Chemistry Chemical Physics, 2016 , vol. 18, # 19 p. 13538 - 13545 Title/Abstract Full Text View citing articles Show Details

Marto, Joana; Ascenso, Andreia; Gonçalves, Lídia M.; Gouveia, Luís F.; Manteigas, Patrícia; Pinto, Pedro; Oliveira, Eduardo; Almeida, António J.; Ribeiro, Helena M.

Drug Delivery, 2016 , vol. 23, # 5 p. 1594 - 1607 Title/Abstract Full Text View citing articles Show Details

Erland, Lauren A. E.; Murch, Susan J.; Reiter, Russel J.; Saxena, Praveen K.

Plant Signaling and Behavior, 2015 , vol. 10, # 11 art. no. E1096469 Title/Abstract Full Text View citing articles Show Details

Byeon, Yeong; Back, Kyoungwhan

Applied Microbiology and Biotechnology, 2016 , vol. 100, # 15 p. 6683 - 6691 Title/Abstract Full Text View citing articles Show Details

Wang, Yi-Fu; Hsu, Yu-Juei; Wu, Hsu-Feng; Lee, Guan-Lin; Yang, Ya-Sung; Wu, Jing-Yiing; Yet, Shaw-Fang; Wu, Kenneth K.; Kuo, Cheng-Chin

Circulation Research, 2016 , vol. 119, # 2 p. 222 - 236 Title/Abstract Full Text View citing articles Show Details

Letra-Vilela, Ricardo; Sánchez-Sánchez, Ana María; Rocha, Ana Maia; Martin, Vanesa; Branco-Santos, Joana; Puente-Moncada, Noelia; Santa-Marta, Mariana; Outeiro, Tiago Fleming; Antolín, Isaac; Rodriguez, Carmen; Herrera, Federico

Molecular and Cellular Endocrinology, 2016 , vol. 434, p. 238 - 249 Title/Abstract Full Text View citing articles Show Details

Spindler, Anna; Stefan, Katja; Wiese, Michael

Journal of Medicinal Chemistry, 2016 , vol. 59, # 13 p. 6121 - 6135 Title/Abstract Full Text View citing articles Show Details

Yan, Shihan; Wei, Dongshan; Tang, Mingjie; Shi, Changcheng; Zhang, Mingkun; Yang, Zhongbo; Du, Chunlei; Cui, Hong-Liang

IEEE Transactions on Terahertz Science and Technology, 2016 , vol. 6, # 4 art. no. 7497010, p. 532 - 540 Title/Abstract Full Text View citing articles Show Details

NATIONAL HEALTH RESEARCH INSTITUTES; KUO, Cheng-Chin; WU, Kenneth Kun-Yu

Patent: WO2016/115188 A1, 2016 ; Title/Abstract Full Text Show Details

Wang, Jin; Wang, Zhi-Min; Li, Xue-Mei; Li, Fan; Wu, Jia-Jia; Kong, Ling-Yi; Wang, Xiao-Bing

Bioorganic and Medicinal Chemistry, 2016 , vol. 24, # 18 p. 4324 - 4338 Title/Abstract Full Text View citing articles Show Details

Yokoo, Hidetomo; Ohsaki, Ayumi; Kagechika, Hiroyuki; Hirano, Tomoya

Tetrahedron, 2016 , vol. 72, # 39 p. 5872 - 5879 Title/Abstract Full Text Show Details

Martínez-Guerrero, Lucy J.; Morales, Mark; Ekins, Sean; Wright, Stephen H.

Molecular Pharmacology, 2016 , vol. 90, # 3 p. 254 - 264 Title/Abstract Full Text Show Details

Jiang, Yan-Hong; Yan, Chao-Guo

Synthesis (Germany), 2016 , vol. 48, # 18 art. no. SS-2016-H0064-OP, p. 3057 - 3064 Title/Abstract Full Text Show Details

Toselli, Francesca; Dodd, Peter R.; Gillam, Elizabeth M. J.

Drug Metabolism Reviews, 2016 , vol. 48, # 3 p. 379 - 404 Title/Abstract Full Text Show Details

Shmatova, Olga I.; Khrustalev, Victor N.; Nenajdenko, Valentine G.

Organic Letters, 2016 , vol. 18, # 18 p. 4494 - 4497 Title/Abstract Full Text Show Details

People's Liberation Army Second Military Medical University; Sheng, Chunquan; Zhang, Wannian; Dong, Guoqiang; Chen, Shuqiang; Li, Zhengang; Mou, Zhenyuan; Yao, Jianzhong; Liu, Na; Wu, Shanchao; Fang, Kun

Patent: CN105418610 A, 2016 ; Title/Abstract Full Text Show Details

Institute of Chemistry Chinese Academy of Sciences; Shi, Yian; Li, Jing; Liu, Mao; Tian, Hua

Patent: CN105566347 A, 2016 ; Title/Abstract Full Text Show Details

Zulfiker, Abu Hasanat Md; Sohrabi, Mohsen; Qi, Ji; Matthews, Ben; Wei, Ming Q; Grice, I. Darren

Journal of Pharmaceutical and Biomedical Analysis, 2016 , vol. 129, p. 260 - 272 Title/Abstract Full Text Show Details

Adamska, Iwona; Lewczuk, Bogdan; Markowska, Magdalena; Majewski, Pawel M.

Journal of Photochemistry and Photobiology B: Biology, 2016 , vol. 164, p. 335 - 343 Title/Abstract Full Text Show Details

Saya, Jordy M.; Oppelaar, Barry; Cioc, RǍzvan C.; Van Der Heijden, Gydo; Vande Velde, Christophe M. L.; Orru, Romano V. A.; Ruijter, Eelco

Chemical Communications, 2016 , vol. 52, # 84 p. 12482 - 12485 Title/Abstract Full Text Show Details

32 of 239

Comment (Pharmacological Data)

Bioactivities present

Reference

Back, Kyoungwhan; Tan, Dun-Xian; Reiter, Russel J.

Journal of Pineal Research, 2016 , vol. 61, # 4 p. 426 - 437 Title/Abstract Full Text Show Details

Sawant, Rajiv T.; Stevens, Marc Y.; Sköld, Christian; Odell, Luke R.

Organic Letters, 2016 , vol. 18, # 20 p. 5392 - 5395 Title/Abstract Full Text Show Details

Yang, Yajun; Zhu, Cuiju; Zhang, Min; Huang, Shijun; Lin, Jingjing; Pan, Xiandao; Su, Weiping

Chemical Communications, 2016 , vol. 52, # 87 p. 12869 - 12872 Title/Abstract Full Text Show Details

Faulkner, Katherine C.; Hurley, Katherine A.; Weibel, Douglas B.

Bioorganic and Medicinal Chemistry Letters, 2016 , vol. 26, # 22 p. 5539 - 5544 Title/Abstract Full Text Show Details

Journal of Medicinal Chemistry, 2016 , vol. 59, # 21 p. 9967 - 9973 Title/Abstract Full Text Show Details

SIGNUM BIOSCIENCES, INC.; Vafai, Scott; Voronkov, Michael; Stock, Maxwell; Stock, Jeffry B.; Lee, Seung-Yub; Li, Zhu; Gu, Haoming

Patent: US9486441 B2, 2016 ; Title/Abstract Full Text Show Details

Hanbat National University Academic Cooperation; Park, Jung Ho; Jang, Mi; Kim, Jae Kwan

Patent: KR2016/46450 A, 2016 ; Title/Abstract Full Text Show Details

Horton, William; Sood, Abha; Peerannawar, Swarada; Kugyela, Nandor; Kulkarni, Aditya; Tulsan, Rekha; Tran, Chris D.; Soule, Jessica; LeVine, Harry; Török, Béla; Török, Marianna

Bioorganic and Medicinal Chemistry Letters, 2017 , vol. 27, # 2 p. 232 - 236 Title/Abstract Full Text Show Details

Setyaningsih, Widiastuti; Saputro, Irfan E.; Carrera, Ceferino A.; Palma, Miguel; Barroso, Carmelo G.

Food Chemistry, 2017 , vol. 225, p. 1 - 9 Title/Abstract Full Text Show Details

Ramos, Eva; Patiño, Paloma; Reiter, Russel J.; Gil-Martín, Emilio; Marco-Contelles, José; Parada, Esther; los Rios, Cristobal de; Romero, Alejandro; Egea, Javier

Free Radical Biology and Medicine, 2017 , vol. 104, p. 32 - 53 Title/Abstract Full Text Show Details

Brandt, Simon D.; Kavanagh, Pierce V.; Dowling, Geraldine; Talbot, Brian; Westphal, Folker; Meyer, Markus R.; Maurer, Hans H.; Halberstadt, Adam L. Drug Testing and Analysis, 2017 , vol. 9, # 1 p. 115 - 126 Title/Abstract Full Text Show Details

Pietri, Jose E.; Pakpour, Nazzy; Napoli, Eleonora; Song, Gyu; Pietri, Eduardo; Potts, Rashaun; Cheung, Kong W.; Walker, Gregory; Riehle, Michael A.; Starcevich, Hannah; Giulivi, Cecilia; Lewis, Edwin E.; Luckhart, Shirley

Biochemical Journal, 2016 , vol. 473, # 20 p. 3487 - 3503 Title/Abstract Full Text Show Details

Aguer, Céline; Piccolo, Brian D.; Fiehn, Oliver; Adams, Sean H.; Harper, Mary-Ellen

FASEB Journal, 2017 , vol. 31, # 2 p. 814 - 827 Title/Abstract Full Text Show Details

Sanz Sharley, Daniel D.; Williams, Jonathan M. J.

Chemical Communications, 2017 , vol. 53, # 12 p. 2020 - 2023 Title/Abstract Full Text Show Details

Sun Yat-Sen University; Pi, Rongbiao; Yang, Xiaohong; Liu, Xingguo; Chen, Ziwei; Wang, Shengnan

Patent: CN105906608 A, 2016 ; Title/Abstract Full Text Show Details

Fujinoki, Masakatsu; Takei, Gen L.

Journal of Reproduction and Development, 2017 , vol. 63, # 1 p. 67 - 74 Title/Abstract Full Text Show Details

Geffard, Michel; Mangas, Arturo; Coveñas, Rafael

Biomedical Reports, 2017 , vol. 6, # 3 p. 307 - 313 Title/Abstract Full Text Show Details

Lee, Hyoung Yool; Back, Kyoungwhan

Journal of Pineal Research, 2017 , vol. 62, # 2 art. no. E12379 Title/Abstract Full Text Show Details

Barbanti, Piero; Aurilia; Egeo; Fofi; Palmirotta

Expert Opinion on Investigational Drugs, 2017 , vol. 26, # 3 p. 269 - 277 Title/Abstract Full Text Show Details

33 of 239

Comment (Pharmacological Data)

physiological behaviour discussed

34 of 239

35 of 239

36 of 239

37 of 239

38 of 239

39 of 239

40 of 239

41 of 239

Reference

Molecular and Cellular Endocrinology, 2016 , vol. 434, p. 238 - 249 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Martínez-Guerrero, Lucy J.; Morales, Mark; Ekins, Sean; Wright, Stephen H.

Molecular Pharmacology, 2016 , vol. 90, # 3 p. 254 - 264 Title/Abstract Full Text Show Details

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Faulkner, Katherine C.; Hurley, Katherine A.; Weibel, Douglas B.

Bioorganic and Medicinal Chemistry Letters, 2016 , vol. 26, # 22 p. 5539 - 5544 Title/Abstract Full Text Show Details

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Oda, Shingo; Fujiwara, Ryoichi; Kutsuno, Yuki; Fukami, Tatsuki; Itoh, Tomoo; Yokoi, Tsuyoshi; Nakajima, Miki

Drug Metabolism and Disposition, 2015 , vol. 43, # 6 p. 812 - 818 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Herington, Jennifer L.; Swale, Daniel R.; Brown, Naoko; Shelton, Elaine L.; Choi, Hyehun; Williams, Charles H.; Hong, Charles C.; Paria, Bibhash C.; Denton, Jerod S.; Reese, Jeff

PLoS ONE, 2015 , vol. 10, # 11 art. no. E0143243 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Odagaki, Yuji; Kinoshita, Masakazu; Toyoshima, Ryoichi

European Journal of Pharmacology, 2014 , vol. 726, # 1 p. 109 - 115 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Blough, Bruce E.; Landavazo, Antonio; Partilla, John S.; Decker, Ann M.; Page, Kevin M.; Baumann, Michael H.; Rothman, Richard B.

Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 19 p. 4754 - 4758 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

CYP2D18-LR of rat

Further Details (Pharmacological Data)

Michaelis constant (Km)

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

192 μmol/l

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

CYP2D18-LR of rat

Further Details (Pharmacological Data)

intrinsic clearance (CL)

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

0.0005

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

42 of 239

43 of 239

44 of 239

45 of 239

46 of 239

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

CYP2D18-LR of rat

Further Details (Pharmacological Data)

maximal velocity (Vmax)

Type (Pharmacological Data)

Vmax

Value of Type (Pharmacological Data)

0.09 pmol*min/pmol

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

CYP2D18-LR of rat

Metabolite (Pharmacological Data)

3-(2-aminoethyl)-1H-indol-5-ol [Reaxys RN: 143524]

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

CYP2D2-HR of rat

Further Details (Pharmacological Data)

Michaelis constant (Km)

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

45 μmol/l

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

CYP2D2-HR of rat

Further Details (Pharmacological Data)

intrinsic clearance (CL)

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

0.0062

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

CYP2D2-HR of rat

Further Details (Pharmacological Data)

maximal velocity (Vmax)

Type (Pharmacological Data)

Vmax

Value of Type

0.28 pmol*min/pmol

(Pharmacological Data)

47 of 239

48 of 239

49 of 239

50 of 239

51 of 239

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

CYP2D2-HR of rat

Metabolite (Pharmacological Data)

3-(2-aminoethyl)-1H-indol-5-ol [Reaxys RN: 143524]

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

CYP2D4-LR of rat

Further Details (Pharmacological Data)

Michaelis constant (Km)

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

82 μmol/l

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

CYP2D4-LR of rat

Further Details (Pharmacological Data)

intrinsic clearance (CL)

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

0.0011

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

CYP2D4-LR of rat

Further Details (Pharmacological Data)

maximal velocity (Vmax)

Type (Pharmacological Data)

Vmax

Value of Type (Pharmacological Data)

0.09 pmol*min/pmol

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

CYP2D4-LR of rat

Metabolite (Pharmacological Data)

3-(2-aminoethyl)-1H-indol-5-ol [Reaxys RN: 143524]

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59

Title/Abstract Full Text View citing articles Show Details

52 of 239

53 of 239

54 of 239

55 of 239

56 of 239

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

CYP2D6-HR of human

Further Details (Pharmacological Data)

Michaelis constant (Km)

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

20 μmol/l

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

CYP2D6-HR of human

Further Details (Pharmacological Data)

Michaelis constant (Km)

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

35 μmol/l

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

CYP2D6-HR of human

Further Details (Pharmacological Data)

intrinsic clearance (CL)

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

3.3514

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

CYP2D6-HR of human

Further Details (Pharmacological Data)

intrinsic clearance (CL)

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

7.29

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

CYP2D6-HR of human

Further Details (Pharmacological Data)

maximal velocity (Vmax)

57 of 239

58 of 239

59 of 239

60 of 239

61 of 239

Type (Pharmacological Data)

Vmax

Value of Type (Pharmacological Data)

117.3 pmol*min/pmol

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

CYP2D6-HR of human

Further Details (Pharmacological Data)

maximal velocity (Vmax)

Type (Pharmacological Data)

Vmax

Value of Type (Pharmacological Data)

145.8 pmol*min/pmol

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

CYP2D6-HR of human

Metabolite (Pharmacological Data)

3-(2-aminoethyl)-1H-indol-5-ol [Reaxys RN: 143524]

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

CYP2D6-LR of human

Further Details (Pharmacological Data)

Michaelis constant (Km)

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

57 μmol/l

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

CYP2D6-LR of human

Further Details (Pharmacological Data)

intrinsic clearance (CL)

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

0.4489

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

CYP2D6-LR of human

62 of 239

63 of 239

64 of 239

65 of 239

66 of 239

Further Details (Pharmacological Data)

maximal velocity (Vmax)

Type (Pharmacological Data)

Vmax

Value of Type (Pharmacological Data)

25.59 pmol*min/pmol

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

CYP2D6-LR of human

Metabolite (Pharmacological Data)

3-(2-aminoethyl)-1H-indol-5-ol [Reaxys RN: 143524]

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

brain microsomes of rat

Further Details (Pharmacological Data)

Michaelis constant (Km)

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

250 μmol/l

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

brain microsomes of rat

Further Details (Pharmacological Data)

intrinsic clearance (CL)

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

0.0016

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

brain microsomes of rat

Further Details (Pharmacological Data)

maximal velocity (Vmax)

Type (Pharmacological Data)

Vmax

Value of Type (Pharmacological Data)

0.39 pmol*min/mg

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

67 of 239

68 of 239

69 of 239

70 of 239

71 of 239

Species or Test-System (Pharmacological Data)

brain microsomes of rat

Metabolite (Pharmacological Data)

3-(2-aminoethyl)-1H-indol-5-ol [Reaxys RN: 143524]

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

liver microsomes allelic variant 2D6*4*4 of human

Further Details (Pharmacological Data)

Michaelis constant (Km)

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

412 μmol/l

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

liver microsomes allelic variant 2D6*4*4 of human

Further Details (Pharmacological Data)

intrinsic clearance (CL)

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

0.1184

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

liver microsomes allelic variant 2D6*4*4 of human

Further Details (Pharmacological Data)

maximal velocity (Vmax)

Type (Pharmacological Data)

Vmax

Value of Type (Pharmacological Data)

48.79 pmol*min/mg

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

liver microsomes allelic variant 2D6*4*4 of human

Metabolite (Pharmacological Data)

3-(2-aminoethyl)-1H-indol-5-ol [Reaxys RN: 143524]

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

liver microsomes of human

72 of 239

73 of 239

74 of 239

75 of 239

76 of 239

Further Details (Pharmacological Data)

Michaelis constant (Km)

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

61 μmol/l

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

liver microsomes of human

Further Details (Pharmacological Data)

intrinsic clearance (CL)

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

4.7951

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

liver microsomes of human

Further Details (Pharmacological Data)

maximal velocity (Vmax)

Type (Pharmacological Data)

Vmax

Value of Type (Pharmacological Data)

292.5 pmol*min/mg

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

liver microsomes of human

Metabolite (Pharmacological Data)

3-(2-aminoethyl)-1H-indol-5-ol [Reaxys RN: 143524]

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

liver microsomes of rat

Further Details (Pharmacological Data)

Michaelis constant (Km)

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

31 μmol/l

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

77 of 239

78 of 239

79 of 239

80 of 239

81 of 239

Species or Test-System (Pharmacological Data)

liver microsomes of rat

Further Details (Pharmacological Data)

intrinsic clearance (CL)

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

1.3016

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

liver microsomes of rat

Further Details (Pharmacological Data)

maximal velocity (Vmax)

Type (Pharmacological Data)

Vmax

Value of Type (Pharmacological Data)

40.35 pmol*min/mg

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or Test-System (Pharmacological Data)

liver microsomes of rat

Metabolite (Pharmacological Data)

3-(2-aminoethyl)-1H-indol-5-ol [Reaxys RN: 143524]

Reference

Haduch, Anna; Bromek, Ewa; Sadakierska-Chudy, Anna; Wójcikowski, Jacek; Daniel, Władysława A.

Pharmacological Research, 2013 , vol. 67, # 1 p. 53 - 59 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

De Bruyn, Tom; Van Westen, Gerard J.P.; IJzerman, Adriaan P.; Stieger, Bruno; De Witte, Peter; Augustijns, Patrick F.; Annaert, Pieter P.

Molecular Pharmacology, 2013 , vol. 83, # 6 p. 1257 - 1267 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

enzyme activity; inhibition of

Species or Test-System (Pharmacological Data)

acetylcholinesterase of electric eel

Concentration (Pharmacological Data)

0.001 mol/l

Kind of Dosing (Pharmacological Data)

title compound dissolved in buffer containing not more than 10percent MeOH

Further Details (Pharmacological Data)

inhibition rate of comparative compound at 3.4E-4 M: 100percent

Results

molecular target: acetylcholinesterase

Reference

Khorana, Nantaka; Changwichit, Kanokwan; Ingkaninan, Kornkanok; Utsintong, Maleeruk

Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2885 - 2888 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

enzyme activity; inhibition of

Species or Test-System (Pharmacological Data)

acetylcholinesterase of electric eel

Concentration (Pharmacological Data)

0.001 mol/l

Kind of Dosing

title compound dissolved in buffer containing not more than 10percent MeOH

(Pharmacological Data)

82 of 239

83 of 239

84 of 239

85 of 239

Further Details (Pharmacological Data)

inhibition rate of comparative compound at 3.4E-4 M: 100percent

Type (Pharmacological Data)

inhibition rate

Value of Type (Pharmacological Data)

7.19 percent

Reference

Khorana, Nantaka; Changwichit, Kanokwan; Ingkaninan, Kornkanok; Utsintong, Maleeruk

Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2885 - 2888 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

enzyme activity; inhibition of

Species or Test-System (Pharmacological Data)

recombinant acetylcholinesterase of human

Concentration (Pharmacological Data)

0.001 mol/l

Kind of Dosing (Pharmacological Data)

title compound dissolved in buffer containing not more than 10percent MeOH

Results

molecular target: human acetylcholinesterase

Reference

Khorana, Nantaka; Changwichit, Kanokwan; Ingkaninan, Kornkanok; Utsintong, Maleeruk

Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2885 - 2888 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

enzyme activity; inhibition of

Species or Test-System (Pharmacological Data)

recombinant acetylcholinesterase of human

Concentration (Pharmacological Data)

0.001 mol/l

Kind of Dosing (Pharmacological Data)

title compound dissolved in buffer containing not more than 10percent MeOH

Type (Pharmacological Data)

inhibition rate

Value of Type (Pharmacological Data)

14.68 percent

Reference

Khorana, Nantaka; Changwichit, Kanokwan; Ingkaninan, Kornkanok; Utsintong, Maleeruk

Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2885 - 2888 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor binding affinity

Species or Test-System (Pharmacological Data)

brain membranes of Wistar rat

Sex

male

Further Details (Pharmacological Data)

in presence of 30 μmol/l spermine; radioligand binding assay ; radioligand: [3H]MK-801

Results

molecular target: NMDA receptor

Reference

Berger; Palangsuntikul; Rebernik; Wolschann; Berner

Current Medicinal Chemistry, 2012 , vol. 19, # 18 p. 3044 - 3057 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor binding affinity

Species or Test-System (Pharmacological Data)

brain membranes of Wistar rat

Sex

male

Further Details (Pharmacological Data)

in presence of 30 μmol/l spermine; radioligand binding assay ; radioligand: [3H]MK-801; IC50 related to: NMDA receptor

Type (Pharmacological Data)

IC50

Value of Type (Pharmacological Data)

179 μmol/l

86 of 239

87 of 239

88 of 239

89 of 239

90 of 239

Reference

Berger; Palangsuntikul; Rebernik; Wolschann; Berner

Current Medicinal Chemistry, 2012 , vol. 19, # 18 p. 3044 - 3057 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor binding affinity

Species or Test-System (Pharmacological Data)

brain membranes of Wistar rat

Sex

male

Further Details (Pharmacological Data)

radioligand binding assay; radioligand: [3H]MK-801

Results

molecular target: NMDA receptor

Reference

Berger; Palangsuntikul; Rebernik; Wolschann; Berner

Current Medicinal Chemistry, 2012 , vol. 19, # 18 p. 3044 - 3057 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor binding affinity

Species or Test-System (Pharmacological Data)

brain membranes of Wistar rat

Sex

male

Further Details (Pharmacological Data)

radioligand binding assay; radioligand: [3H]MK-801; IC50 related to: NMDA receptor

Type (Pharmacological Data)

IC50

Value of Type (Pharmacological Data)

19.2 μmol/l

Reference

Berger; Palangsuntikul; Rebernik; Wolschann; Berner

Current Medicinal Chemistry, 2012 , vol. 19, # 18 p. 3044 - 3057 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor binding affinity

Species or Test-System (Pharmacological Data)

hippocampal CA1 + dentate gyrus membranes of Wistar rat

Sex

male

Further Details (Pharmacological Data)

radioligand binding assay; radioligand: [3H]-OH-DPAT

Results

molecular target: 5-HT1A receptor

Reference

Berger; Palangsuntikul; Rebernik; Wolschann; Berner

Current Medicinal Chemistry, 2012 , vol. 19, # 18 p. 3044 - 3057 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor binding affinity

Species or Test-System (Pharmacological Data)

hippocampal CA1 + dentate gyrus membranes of Wistar rat

Sex

male

Further Details (Pharmacological Data)

radioligand binding assay; radioligand: [3H]-OH-DPAT; IC50 related to: 5-HT1A receptor

Type (Pharmacological Data)

IC50

Value of Type (Pharmacological Data)

0.0049 - 0.0068 μmol/l

Reference

Berger; Palangsuntikul; Rebernik; Wolschann; Berner

Current Medicinal Chemistry, 2012 , vol. 19, # 18 p. 3044 - 3057 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor binding affinity

Species or Test-System (Pharmacological Data)

prefrontal cortex membranes of Wistar rat

91 of 239

92 of 239

93 of 239

94 of 239

Sex

male

Further Details (Pharmacological Data)

radioligand binding assay; radioligand: [3H]ketanserin

Results

molecular target: 5-HT2A receptor

Reference

Berger; Palangsuntikul; Rebernik; Wolschann; Berner

Current Medicinal Chemistry, 2012 , vol. 19, # 18 p. 3044 - 3057 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor binding affinity

Species or Test-System (Pharmacological Data)

prefrontal cortex membranes of Wistar rat

Sex

male

Further Details (Pharmacological Data)

radioligand binding assay; radioligand: [3H]ketanserin; IC50 related to: 5-HT2A receptor

Type (Pharmacological Data)

IC50

Value of Type (Pharmacological Data)

10.8 μmol/l

Reference

Berger; Palangsuntikul; Rebernik; Wolschann; Berner

Current Medicinal Chemistry, 2012 , vol. 19, # 18 p. 3044 - 3057 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

menthol-stimulated 45Ca2+ influx; inhibition of

Species or Test-System (Pharmacological Data)

T-REx-293 cells; genetically modified/infected with: pcDNA5TO-hTRPM8

Further Details (Pharmacological Data)

hTRPM8: human transient receptor potential melastatin 8

Type (Pharmacological Data)

IC50

Value of Type (Pharmacological Data)

12.4 μmol/l

Location

supporting information

Reference

Defalco, Jeff; Steiger, Daniel; Dourado, Michelle; Emerling, Daniel; Duncton, Matthew A.J.

Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 23 p. 7076 - 7079 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

menthol-stimulated 45Ca2+ influx; inhibition of

Species or Test-System (Pharmacological Data)

T-REx-293 cells; genetically modified/infected with: pcDNA5TO-hTRPM8

Further Details (Pharmacological Data)

hTRPM8: human transient receptor potential melastatin 8

Results

molecular target: TRPM8

Location

supporting information

Reference

Defalco, Jeff; Steiger, Daniel; Dourado, Michelle; Emerling, Daniel; Duncton, Matthew A.J.

Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 23 p. 7076 - 7079 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

icilin-stimulated 45Ca2+ influx; inhibition of

Species or Test-System (Pharmacological Data)

T-REx-293 cells; genetically modified/infected with: pcDNA5TO-hTRPM8

Further Details (Pharmacological Data)

hTRPM8: human transient receptor potential melastatin 8

Type (Pharmacological Data)

IC50

Value of Type (Pharmacological Data)

11.6 μmol/l

Location

supporting information

Reference

Defalco, Jeff; Steiger, Daniel; Dourado, Michelle; Emerling, Daniel; Duncton, Matthew A.J.

Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 23 p. 7076 - 7079 Title/Abstract Full Text View citing articles Show Details

95 of 239

96 of 239

97 of 239

98 of 239

99 of 239

Effect (Pharmacological Data)

icilin-stimulated 45Ca2+ influx; inhibition of

Species or Test-System (Pharmacological Data)

T-REx-293 cells; genetically modified/infected with: pcDNA5TO-hTRPM8

Further Details (Pharmacological Data)

hTRPM8: human transient receptor potential melastatin 8

Results

molecular target: TRPM8

Location

supporting information

Reference

Defalco, Jeff; Steiger, Daniel; Dourado, Michelle; Emerling, Daniel; Duncton, Matthew A.J.

Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 23 p. 7076 - 7079 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor binding affinity

Species or Test-System (Pharmacological Data)

COS-7 cell membranes; genetically modified/infected with: h5-HT4b receptor

Kind of Dosing (Pharmacological Data)

comparative comp. dissolved in phosphate buffered saline (PBS) and DMSO (max. conc. 1percent v/v)

Further Details (Pharmacological Data)

radioligand: [3H]-GR113808 at 0.25 nM

Results

molecular target: human 5-HT4b receptor

Reference

Hanna-Elias, Amir; Manallack, David T.; Levit, Alla; Nguyen, William; Ayad, Fadi; Perera, Glen; Shapiro, Marina; Irving, Helen R.; Coupar, Ian M.; Iskander, Magdy N.

Medicinal Chemistry, 2010 , vol. 6, # 6 p. 344 - 354 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor binding affinity

Species or Test-System (Pharmacological Data)

COS-7 cell membranes; genetically modified/infected with: h5-HT4b receptor

Kind of Dosing (Pharmacological Data)

comparative comp. dissolved in phosphate buffered saline (PBS) and DMSO (max. conc. 1percent v/v)

Further Details (Pharmacological Data)

radioligand: [3H]-GR113808 at 0.25 nM; displacement rate (title comp.): 99percent at 1 μM

Results

molecular target: human 5-HT4b receptor

Reference

Hanna-Elias, Amir; Manallack, David T.; Levit, Alla; Nguyen, William; Ayad, Fadi; Perera, Glen; Shapiro, Marina; Irving, Helen R.; Coupar, Ian M.; Iskander, Magdy N.

Medicinal Chemistry, 2010 , vol. 6, # 6 p. 344 - 354 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor binding affinity

Species or Test-System (Pharmacological Data)

COS-7 cell membranes; genetically modified/infected with: h5-HT4b receptor

Kind of Dosing (Pharmacological Data)

comparative comp. dissolved in phosphate buffered saline (PBS) and DMSO (max. conc. 1percent v/v)

Further Details (Pharmacological Data)

radioligand: [3H]-GR113808 at 0.25 nM; displacement rate (title comp.): 99percent at 1 μM; pKi related to: human 5-HT4b receptor

Type (Pharmacological Data)

pKi

Value of Type (Pharmacological Data)

6.83

Reference

Hanna-Elias, Amir; Manallack, David T.; Levit, Alla; Nguyen, William; Ayad, Fadi; Perera, Glen; Shapiro, Marina; Irving, Helen R.; Coupar, Ian M.; Iskander, Magdy N.

Medicinal Chemistry, 2010 , vol. 6, # 6 p. 344 - 354 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor binding affinity

Species or Test-System (Pharmacological Data)

COS-7 cell membranes; genetically modified/infected with: h5-HT4b receptor

100 of 239

101 of 239

102 of 239

Kind of Dosing (Pharmacological Data)

comparative comp. dissolved in phosphate buffered saline (PBS) and DMSO (max. conc. 1percent v/v)

Further Details (Pharmacological Data)

radioligand: [3H]-GR113808 at 0.25 nM; pKi related to: human 5-HT4b receptor

Type (Pharmacological Data)

pKi

Value of Type (Pharmacological Data)

6.83

Reference

Hanna-Elias, Amir; Manallack, David T.; Levit, Alla; Nguyen, William; Ayad, Fadi; Perera, Glen; Shapiro, Marina; Irving, Helen R.; Coupar, Ian M.; Iskander, Magdy N.

Medicinal Chemistry, 2010 , vol. 6, # 6 p. 344 - 354 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor binding affinity

Species or Test-System (Pharmacological Data)

COS-7 cell membranes; genetically modified/infected with: h5-HT4d receptor

Concentration (Pharmacological Data)

1 μmol/l

Kind of Dosing (Pharmacological Data)

comparative comp. dissolved in phosphate buffered saline (PBS) and DMSO (max. conc. 1percent v/v)

Further Details (Pharmacological Data)

radioligand: [3H]-GR113808 at 0.25 nM

Results

molecular target: human 5-HT4d receptor

Reference

Hanna-Elias, Amir; Manallack, David T.; Levit, Alla; Nguyen, William; Ayad, Fadi; Perera, Glen; Shapiro, Marina; Irving, Helen R.; Coupar, Ian M.; Iskander, Magdy N.

Medicinal Chemistry, 2010 , vol. 6, # 6 p. 344 - 354 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor binding affinity

Species or Test-System (Pharmacological Data)

COS-7 cell membranes; genetically modified/infected with: h5-HT4d receptor

Concentration (Pharmacological Data)

1 μmol/l

Kind of Dosing (Pharmacological Data)

comparative comp. dissolved in phosphate buffered saline (PBS) and DMSO (max. conc. 1percent v/v)

Further Details (Pharmacological Data)

radioligand: [3H]-GR113808 at 0.25 nM; rate of displacement related to: human 5-HT4d receptor

Type (Pharmacological Data)

rate of displacement

Value of Type (Pharmacological Data)

100 percent

Reference

Hanna-Elias, Amir; Manallack, David T.; Levit, Alla; Nguyen, William; Ayad, Fadi; Perera, Glen; Shapiro, Marina; Irving, Helen R.; Coupar, Ian M.; Iskander, Magdy N.

Medicinal Chemistry, 2010 , vol. 6, # 6 p. 344 - 354 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor binding affinity

Species or Test-System (Pharmacological Data)

COS-7 cell membranes; genetically modified/infected with: human 5-HT4b receptor

Concentration (Pharmacological Data)

1 μmol/l

Kind of Dosing (Pharmacological Data)

comparative comp. dissolved in phosphate buffered saline (PBS) and DMSO (max. conc. 1percent v/v)

Further Details (Pharmacological Data)

radioligand: [3H]-GR113808 at 0.25 nM

Results

molecular target: human 5-HT4b receptor

Reference

Hanna-Elias, Amir; Manallack, David T.; Levit, Alla; Nguyen, William; Ayad, Fadi; Perera, Glen; Shapiro, Marina; Irving, Helen R.; Coupar, Ian M.; Iskander, Magdy N.

Medicinal Chemistry, 2010 , vol. 6, # 6 p. 344 - 354 Title/Abstract Full Text View citing articles Show Details

103 of 239

104 of 239

105 of 239

106 of 239

Effect (Pharmacological Data)

receptor binding affinity

Species or Test-System (Pharmacological Data)

COS-7 cell membranes; genetically modified/infected with: human 5-HT4b receptor

Concentration (Pharmacological Data)

1 μmol/l

Kind of Dosing (Pharmacological Data)

comparative comp. dissolved in phosphate buffered saline (PBS) and DMSO (max. conc. 1percent v/v)

Further Details (Pharmacological Data)

radioligand: [3H]-GR113808 at 0.25 nM; rate of displacement related to: human 5-HT4b receptor

Type (Pharmacological Data)

rate of displacement

Value of Type (Pharmacological Data)

100 percent

Reference

Hanna-Elias, Amir; Manallack, David T.; Levit, Alla; Nguyen, William; Ayad, Fadi; Perera, Glen; Shapiro, Marina; Irving, Helen R.; Coupar, Ian M.; Iskander, Magdy N.

Medicinal Chemistry, 2010 , vol. 6, # 6 p. 344 - 354 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor binding affinity

Species or Test-System (Pharmacological Data)

COS-7 cell membranes; genetically modified/infected with: human 5-HT4g receptor

Concentration (Pharmacological Data)

1 μmol/l

Kind of Dosing (Pharmacological Data)

comparative comp. dissolved in phosphate buffered saline (PBS) and DMSO (max. conc. 1percent v/v)

Further Details (Pharmacological Data)

radioligand: [3H]-GR113808 at 0.25 nM

Results

molecular target: human 5-HT4g receptor

Reference

Hanna-Elias, Amir; Manallack, David T.; Levit, Alla; Nguyen, William; Ayad, Fadi; Perera, Glen; Shapiro, Marina; Irving, Helen R.; Coupar, Ian M.; Iskander, Magdy N.

Medicinal Chemistry, 2010 , vol. 6, # 6 p. 344 - 354 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor binding affinity

Species or Test-System (Pharmacological Data)

COS-7 cell membranes; genetically modified/infected with: human 5-HT4g receptor

Concentration (Pharmacological Data)

1 μmol/l

Kind of Dosing (Pharmacological Data)

comparative comp. dissolved in phosphate buffered saline (PBS) and DMSO (max. conc. 1percent v/v)

Further Details (Pharmacological Data)

radioligand: [3H]-GR113808 at 0.25 nM; rate of displacement related to: human 5-HT4g receptor

Type (Pharmacological Data)

rate of displacement

Value of Type (Pharmacological Data)

100 percent

Reference

Hanna-Elias, Amir; Manallack, David T.; Levit, Alla; Nguyen, William; Ayad, Fadi; Perera, Glen; Shapiro, Marina; Irving, Helen R.; Coupar, Ian M.; Iskander, Magdy N.

Medicinal Chemistry, 2010 , vol. 6, # 6 p. 344 - 354 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor binding affinity

Species or Test-System (Pharmacological Data)

COS-7 cell membranes; genetically modified/infected with: 5-HT4b receptor splice variant

Concentration (Pharmacological Data)

1e-6 mol/l

Kind of Dosing (Pharmacological Data)

dissolved in phosphate buffered saline (PBS) and DMSO

Further Details (Pharmacological Data)

[3H]-GR113808 displacement related to: 5-HT4b receptor

107 of 239

108 of 239

109 of 239

110 of 239

Type (Pharmacological Data)

[3H]-GR113808 displacement

Value of Type (Pharmacological Data)

100 percent

Reference

Hanna-Elias, Amir; Manallack, David T.; Berque-Bestel, Isabelle; Irving, Helen R.; Coupar, Ian M.; Iskander, Magdy N.

Australian Journal of Chemistry, 2009 , vol. 62, # 2 p. 150 - 156 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor binding affinity

Species or Test-System (Pharmacological Data)

COS-7 cell membranes; genetically modified/infected with: 5-HT4b receptor splice variant

Concentration (Pharmacological Data)

1e-6 mol/l

Kind of Dosing (Pharmacological Data)

dissolved in phosphate buffered saline (PBS) and DMSO

Results

molecular target: 5-HT4b receptor

Reference

Hanna-Elias, Amir; Manallack, David T.; Berque-Bestel, Isabelle; Irving, Helen R.; Coupar, Ian M.; Iskander, Magdy N.

Australian Journal of Chemistry, 2009 , vol. 62, # 2 p. 150 - 156 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor binding affinity

Species or Test-System (Pharmacological Data)

COS-7 cell membranes; genetically modified/infected with: human 5-HT4b receptor splice variant

Concentration (Pharmacological Data)

1 - 100 μmol/l

Kind of Dosing (Pharmacological Data)

title compound dissolved in phosphate buffered saline

Further Details (Pharmacological Data)

[3H]-GR113808 [(1-(2-(methylsulphonyl)amino)ethyl-4-piperidinyl)methyl-1-methyl-1H-indole-3-carboxylate] as radioligand; inhibition constant (Ki); Ki related to: human 5-HT4b receptor

Type (Pharmacological Data)

log Ki

Value of Type (Pharmacological Data)

-7.57

Reference

Hanna-Elias, Amir; Manallack, David T.; Berque-Bestel, Isabelle; Irving, Helen R.; Coupar, Ian M.; Iskander, Magdy N.

European Journal of Medicinal Chemistry, 2009 , vol. 44, # 7 p. 2952 - 2959 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor binding affinity

Species or Test-System (Pharmacological Data)

COS-7 cell membranes; genetically modified/infected with: human 5-HT4b receptor splice variant

Concentration (Pharmacological Data)

1 - 100 μmol/l

Kind of Dosing (Pharmacological Data)

title compound dissolved in phosphate buffered saline

Further Details (Pharmacological Data)

[3H]-GR113808 [(1-(2-(methylsulphonyl)amino)ethyl-4-piperidinyl)methyl-1-methyl-1H-indole-3-carboxylate] as radioligand

Results

molecular target: human 5-HT4b receptor splice variant

Reference

Hanna-Elias, Amir; Manallack, David T.; Berque-Bestel, Isabelle; Irving, Helen R.; Coupar, Ian M.; Iskander, Magdy N.

European Journal of Medicinal Chemistry, 2009 , vol. 44, # 7 p. 2952 - 2959 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor; binding activity

Species or Test-System (Pharmacological Data)

human embryonic kidney 293 cells

Method (Pharmacological Data)

competitive binding assay; cell membranes incubated in HEPES buffer containing <3H>granisetron and title comp. at 4 deg C, 1 h; reaction terminated by vaccum filtration; radioactivity detd. by using SC; binding affinity to 5-HT3A receptor detd.

Further Details (Pharmacological Data)

SC: scintillation counter; ref. comp.: 5-hydroxytrptamine, m-chlorophenylbiguanide and tryptamine

Type (Pharmacological

Data)

111 of 239

112 of 239

Value of Type (Pharmacological Data)

34.9 μmol/l

Reference

Bower, Kiowa S.; Price, Kerry L.; Sturdee, Laura E.C.; Dayrell, Mariza; Dougherty, Dennis A.; Lummis, Sarah C.R.

European Journal of Pharmacology, 2008 , vol. 580, # 3 p. 291 - 297 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor; binding activity

Species or Test-System (Pharmacological Data)

human embryonic kidney 293 cells

Method (Pharmacological Data)

Further Details (Pharmacological Data)

SC: scintillation counter; ref. comp.: 5-hydroxytrptamine, m-chlorophenylbiguanide and tryptamine

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

21.7 μmol/l

Reference

Bower, Kiowa S.; Price, Kerry L.; Sturdee, Laura E.C.; Dayrell, Mariza; Dougherty, Dennis A.; Lummis, Sarah C.R.

European Journal of Pharmacology, 2008 , vol. 580, # 3 p. 291 - 297 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

Nrf2 activity; inhibition of

Species or Test-System (Pharmacological Data)

lung adenocarcinoma cells transfected with ARE-luciferase reporter vector

Method (Pharmacological Data)

Example 2 A Novel Assay for Nrf2 Inhibitors A high throughput approach to screen compounds was developed. A cell based reporter assay was used to identify agents that can inhibit Nrf2 mediated transcription. Lung adenocarcinoma cells that are stably transfected with ARE-luciferase reporter vector were plated on to 96 well plates. After overnight incubation, cells were pretreated with 12-16 hours with candidate Nrf2 modulators. Luciferase activity was measured after 6 hours of treatment using a luciferase assay system. The decrease in luciferase activity correlates with degree of Nrf2 inhibition.The compounds identified using this assay are identified in Figure 16:Table 5. The known use of each compound is identified in the middle column and the percent luciferase activity is identified in the right hand column.

Results

title compound treatment showed inhibited luciferase activity of 63percent

Location

Page/Page column 9; 57; 16/28-22/28

Reference

THE JOHNS HOPKINS UNIVERSITY

Patent: WO2008/124660 A2, 2008 ; Title/Abstract Full Text Show Details

113 of 239

114 of 239

Effect (Pharmacological Data)

5-HT uptake; inhibition of

Species or Test-System (Pharmacological Data)

HEK-293 MSR cells transfected with hSERT

Method (Pharmacological Data)

inhibition of <3H>-5-HT uptake assayed; cells preincubated with title comp. for 30 min in PBSCM pH 7.4; uptake initiated by addition of <3H>-5-HT (50-100 nM) and continued for 10 min; cells lysed, radiolabeled 5-HT quantified by scintillation counting

Further Details (Pharmacological Data)

hSERT: human serotonin transporter

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

56 μmol/l

Reference

Celik, Leyla; Sinning, Steffen; Severinsen, Kasper; Hansen, Carsten G.; Moller, Maria S.; Bols, Mikael; Wiborg, Ove; Schiott, Birgit

Journal of the American Chemical Society, 2008 , vol. 130, # 12 p. 3853 - 3865 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

5-HT uptake; inhibition of

Species or Test-System (Pharmacological Data)

HEK-293 MSR cells transfected with hSERT, Ala173Thr mutant

Method (Pharmacological Data)

Further Details (Pharmacological Data)

hSERT: human serotonin transporter

Type (Pharmacological Data)

115 of 239

116 of 239

117 of 239

118 of 239

Value of Type (Pharmacological Data)

21 μmol/l

Reference

Celik, Leyla; Sinning, Steffen; Severinsen, Kasper; Hansen, Carsten G.; Moller, Maria S.; Bols, Mikael; Wiborg, Ove; Schiott, Birgit

Journal of the American Chemical Society, 2008 , vol. 130, # 12 p. 3853 - 3865 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

5-HT uptake; inhibition of

Species or Test-System (Pharmacological Data)

HEK-293 MSR cells transfected with hSERT, Ala173Asp mutant

Method (Pharmacological Data)

Further Details (Pharmacological Data)

hSERT: human serotonin transporter

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

13.1 μmol/l

Reference

Celik, Leyla; Sinning, Steffen; Severinsen, Kasper; Hansen, Carsten G.; Moller, Maria S.; Bols, Mikael; Wiborg, Ove; Schiott, Birgit

Journal of the American Chemical Society, 2008 , vol. 130, # 12 p. 3853 - 3865 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

5-HT uptake; inhibition of

Species or Test-System (Pharmacological Data)

HEK-293 MSR cells transfected with hSERT, Ala173Ser mutant

Method (Pharmacological Data)

Further Details (Pharmacological Data)

hSERT: human serotonin transporter

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

21 μmol/l

Reference

Celik, Leyla; Sinning, Steffen; Severinsen, Kasper; Hansen, Carsten G.; Moller, Maria S.; Bols, Mikael; Wiborg, Ove; Schiott, Birgit

Journal of the American Chemical Society, 2008 , vol. 130, # 12 p. 3853 - 3865 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

5-HT uptake; inhibition of

Species or Test-System (Pharmacological Data)

HEK-293 MSR cells transfected with hSERT, Ala173Cys mutant

Method (Pharmacological Data)

Further Details (Pharmacological Data)

hSERT: human serotonin transporter

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

22 μmol/l

Reference

Celik, Leyla; Sinning, Steffen; Severinsen, Kasper; Hansen, Carsten G.; Moller, Maria S.; Bols, Mikael; Wiborg, Ove; Schiott, Birgit

Journal of the American Chemical Society, 2008 , vol. 130, # 12 p. 3853 - 3865 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

5-HT uptake; inhibition of

Species or Test-System (Pharmacological Data)

HEK-293 MSR cells transfected with hSERT, Ala173Met mutant

Method (Pharmacological Data)

Further Details (Pharmacological Data)

hSERT: human serotonin transporter

Type (Pharmacological Data)

119 of 239

120 of 239

121 of 239

122 of 239

Value of Type (Pharmacological Data)

4.5 μmol/l

Reference

Celik, Leyla; Sinning, Steffen; Severinsen, Kasper; Hansen, Carsten G.; Moller, Maria S.; Bols, Mikael; Wiborg, Ove; Schiott, Birgit

Journal of the American Chemical Society, 2008 , vol. 130, # 12 p. 3853 - 3865 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

5-HT uptake; inhibition of

Species or Test-System (Pharmacological Data)

HEK-293 MSR cells transfected with hSERT, Tyr175Phe mutant

Method (Pharmacological Data)

Further Details (Pharmacological Data)

hSERT: human serotonin transporter

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

26 μmol/l

Reference

Celik, Leyla; Sinning, Steffen; Severinsen, Kasper; Hansen, Carsten G.; Moller, Maria S.; Bols, Mikael; Wiborg, Ove; Schiott, Birgit

Journal of the American Chemical Society, 2008 , vol. 130, # 12 p. 3853 - 3865 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

5-HT uptake; inhibition of

Species or Test-System (Pharmacological Data)

HEK-293 MSR cells transfected with hSERT, Ala169Ile mutant

Method (Pharmacological Data)

Further Details (Pharmacological Data)

hSERT: human serotonin transporter

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

6.6 μmol/l

Reference

Celik, Leyla; Sinning, Steffen; Severinsen, Kasper; Hansen, Carsten G.; Moller, Maria S.; Bols, Mikael; Wiborg, Ove; Schiott, Birgit

Journal of the American Chemical Society, 2008 , vol. 130, # 12 p. 3853 - 3865 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

5-HT uptake; inhibition of

Species or Test-System (Pharmacological Data)

HEK-293 MSR cells transfected with hSERT, Thr439Val mutant

Method (Pharmacological Data)

Further Details (Pharmacological Data)

hSERT: human serotonin transporter

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

28 μmol/l

Reference

Celik, Leyla; Sinning, Steffen; Severinsen, Kasper; Hansen, Carsten G.; Moller, Maria S.; Bols, Mikael; Wiborg, Ove; Schiott, Birgit

Journal of the American Chemical Society, 2008 , vol. 130, # 12 p. 3853 - 3865 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

5-HT uptake; inhibition of

Species or Test-System (Pharmacological Data)

HEK-293 MSR cells transfected with hSERT, Thr439Ser mutant

Method (Pharmacological Data)

Further Details (Pharmacological Data)

hSERT: human serotonin transporter

Type (Pharmacological Data)

123 of 239

124 of 239

125 of 239

126 of 239

Value of Type (Pharmacological Data)

25 μmol/l

Reference

Celik, Leyla; Sinning, Steffen; Severinsen, Kasper; Hansen, Carsten G.; Moller, Maria S.; Bols, Mikael; Wiborg, Ove; Schiott, Birgit

Journal of the American Chemical Society, 2008 , vol. 130, # 12 p. 3853 - 3865 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

5-HT uptake; inhibition of

Species or Test-System (Pharmacological Data)

HEK-293 MSR cells transfected with hSERT, Thr439Ala mutant

Method (Pharmacological Data)

Further Details (Pharmacological Data)

hSERT: human serotonin transporter

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

2.55 μmol/l

Reference

Celik, Leyla; Sinning, Steffen; Severinsen, Kasper; Hansen, Carsten G.; Moller, Maria S.; Bols, Mikael; Wiborg, Ove; Schiott, Birgit

Journal of the American Chemical Society, 2008 , vol. 130, # 12 p. 3853 - 3865 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

5-HT uptake; inhibition of

Species or Test-System (Pharmacological Data)

HEK-293 MSR cells transfected with hSERT, Tyr176Phe mutant

Method (Pharmacological Data)

Further Details (Pharmacological Data)

hSERT: human serotonin transporter

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

47 μmol/l

Reference

Celik, Leyla; Sinning, Steffen; Severinsen, Kasper; Hansen, Carsten G.; Moller, Maria S.; Bols, Mikael; Wiborg, Ove; Schiott, Birgit

Journal of the American Chemical Society, 2008 , vol. 130, # 12 p. 3853 - 3865 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

5-HT uptake; inhibition of

Species or Test-System (Pharmacological Data)

HEK-293 MSR cells transfected with hSERT, Ala173Leu mutant

Method (Pharmacological Data)

Further Details (Pharmacological Data)

hSERT: human serotonin transporter

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

4.6 μmol/l

Reference

Celik, Leyla; Sinning, Steffen; Severinsen, Kasper; Hansen, Carsten G.; Moller, Maria S.; Bols, Mikael; Wiborg, Ove; Schiott, Birgit

Journal of the American Chemical Society, 2008 , vol. 130, # 12 p. 3853 - 3865 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

transport; inhibition of

Species or Test-System (Pharmacological Data)

COS-7 cells

Concentration (Pharmacological Data)

Ca. 1 - 500 μmol/l

Method (Pharmacological Data)

cells expressing rSERT incubated with <3H>5-HT in presence of title comp. for 10 min at 37 deg C; radioactivity extracted with NaOH; measured by liquid scintillation spectrometry

Further Details (Pharmacological Data)

rSERT: rat serotonin transporter; 5-HT: serotonin; cocaine used as positive control (IC50 = 0.64 μmol/l)

127 of 239

128 of 239

129 of 239

130 of 239

Type (Pharmacological Data)

IC50

Value of Type (Pharmacological Data)

35.9 μmol/l

Reference

Sogawa; Tagawa; Fujino; Ohyama; Asanuma; Funada; Kitayama

Toxicology Letters, 2007 , vol. 170, # 1 p. 75 - 82 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

membrane currents; inhibition of

Species or Test-System (Pharmacological Data)

Xenopus laevis oocyte

Concentration (Pharmacological Data)

Ca. 0.001 - 10 mmol/l

Method (Pharmacological Data)

oocytes expressing rat NMDA receptor subunits NR1a+2B; Ca(2+)- and Mg(2+)-free solution at 18 deg C; two-electrode voltage clamp at -70 mV; bath application of title comp.; inhibition of currents induced by 100 μmol/l glutamate and 10 μmol/l glycine

Further Details (Pharmacological Data)

NMDA: N-methyl-D-aspartate; further studies using 0.1 or 0.3 mmol/l Mg(2+)

Type (Pharmacological Data)

IC50

Value of Type (Pharmacological Data)

18 μmol/l

Results

title comp. concentration-dependently inhibited glutamate-induced currents; co-application of Mg(2+) attenuated effect of title comp. (table, figure)

Reference

Kloda, Anna; Adams, David J.

British Journal of Pharmacology, 2005 , vol. 144, # 3 p. 323 - 330 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

membrane currents; inhibition of

Species or Test-System (Pharmacological Data)

Xenopus laevis oocyte

Method (Pharmacological Data)

oocytes expressing rat NMDA receptor subunits NR1a+2B; Ca(2+)- and Mg(2+)-free solution at 18 deg C; two-electrode voltage clamp at -120 mV; bath application of title comp.; inhibition of currents induced by 100 μmol/l glutamate and 10 μmol/l glycine

Further Details (Pharmacological Data)

NMDA: N-methyl-D-aspartate

Type (Pharmacological Data)

IC50

Value of Type (Pharmacological Data)

3.6 μmol/l

Results

title comp. concentration-dependently inhibited glutamate-induced currents

Reference

Kloda, Anna; Adams, David J.

British Journal of Pharmacology, 2005 , vol. 144, # 3 p. 323 - 330 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

agonist

Species or Test-System (Pharmacological Data)

CHO cells expressing human 5-HT2C receptors

Method (Pharmacological Data)

in vitro; fluorimetric imaging plate reader assay

Type (Pharmacological Data)

EC50

Value of Type (Pharmacological Data)

3 nmol/l

Results

relative efficacy at 1 μmol/l dose: 87 percent

Reference

Chimia, 2004 , vol. 58, # 9 p. 613 - 620 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

agonist

131 of 239

132 of 239

133 of 239

Species or Test-System (Pharmacological Data)

CHO cells expressing human 5-HT2A receptors

Method (Pharmacological Data)

in vitro; fluorimetric imaging plate reader assay

Type (Pharmacological Data)

EC50

Value of Type (Pharmacological Data)

6 nmol/l

Reference

Chimia, 2004 , vol. 58, # 9 p. 613 - 620 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

agonist

Species or Test-System (Pharmacological Data)

CHO cells expressing human 5-HT2B receptors

Method (Pharmacological Data)

in vitro; fluorimetric imaging plate reader assay

Type (Pharmacological Data)

EC50

Value of Type (Pharmacological Data)

2 nmol/l

Reference

Chimia, 2004 , vol. 58, # 9 p. 613 - 620 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor; binding activity

Species or Test-System (Pharmacological Data)

rat brain membranes

Concentration (Pharmacological Data)

0.01 - 10 μmol/l

Method (Pharmacological Data)

competition experiment: membranes incub. with title comp.+0.1 nmol/l <125I>DAIZAC at room temp.; bound and free radioligand separated by vacuum filtration, analysis by gamma spectrometry

Further Details (Pharmacological Data)

DAIZAC: (S)-5-chloro-3-iodo-2-methoxy-N-(1-azabicyclo<2.2.2>oct-3-yl)benzamide; title comp. effect on binding of <125I>DAIZAC to 5-HT3 receptors studied; pKi estimated using IC50 by the Cheng-Prusoff equation, Ki in mol/l

Type (Pharmacological Data)

pKi

Value of Type (Pharmacological Data)

7.39 dimensionless

Reference

Zhang, Zhang-Jin; Trivedi, Bakula L.; De Paulis, Tomas; Schmidt, Dennis E.; Hewlett, William A.

Naunyn-Schmiedeberg's Archives of Pharmacology, 2002 , vol. 365, # 2 p. 123 - 132 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor; binding activity

Species or Test-System (Pharmacological Data)

mouse neuroblastoma*chinese hamster hybrid NCB20 cells

Concentration (Pharmacological Data)

0.01 - 10 μmol/l

Method (Pharmacological Data)

competition experiment: cells incub. with title comp.+0.1 nmol/l <125I>DAIZAC at room temp.; bound and free radioligand separated by vacuum filtration, analysis by gamma spectrometry

Further Details (Pharmacological Data)

Type (Pharmacological Data)

pKi

Value of Type (Pharmacological Data)

6.05 dimensionless

Reference

Zhang, Zhang-Jin; Trivedi, Bakula L.; De Paulis, Tomas; Schmidt, Dennis E.; Hewlett, William A.

Naunyn-Schmiedeberg's Archives of Pharmacology, 2002 , vol. 365, # 2 p. 123 - 132 Title/Abstract Full Text View citing articles Show Details

134 of 239

135 of 239

136 of 239

137 of 239

Effect (Pharmacological Data)

vasoconstrictive

Species or Test-System (Pharmacological Data)

mongrel dog

Sex

male and female

Route of Application

intraarterial

Concentration (Pharmacological Data)

1 - 100 μg/min

Method (Pharmacological Data)

dogs (15-30 kg) anaesthetized (sodium pentobarbitone); bilateral cervical vagosympathectomy; 1 min intracarotid infusion of title comp.

Further Details (Pharmacological Data)

internal carotid blood flow; antagonists: GR127935 (30 μg/kg), ritanserin (100 μg/kg); 5-HT1B/1D and 5-HT2A receptors

Results

dose-response curve of internal carotid blood flow (diagram); effect of antagonists (diagrams)

Reference

Centurion, David; Ortiz, Mario I; Sanchez-Lopez, Araceli; De Vries, Peter; Saxena, Pramod R; Villalon, Carlos M

British Journal of Pharmacology, 2001 , vol. 132, # 5 p. 983 - 990 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

agonist

Species or Test-System (Pharmacological Data)

guinea pig distal colon longitudinal muscle strips

Method (Pharmacological Data)

in vitro; effect on 5-HT4 receptor-mediated contraction evaluated; strips vertically suspended in organ bath filled with Krebs' solution; 95 percent O2/5 percent CO2; 37 deg C; increasing conc. of title comp. added at 15 min intervals

Further Details (Pharmacological Data)

contractile responses recorded isometrically; responses expressed as percent of max. 5-HT (EC50: 6.3 nmol/l)-evoked contraction

Type (Pharmacological Data)

EC50

Value of Type (Pharmacological Data)

20.8 nmol/l

Results

intrinsic activity of title comp. was 1.03

Reference

Suzuki; Ohuchi; Asanuma; Kaneko; Yokomori; Ito; Isobe; Muramatsu

Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 1 p. 29 - 39 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

agonist

Species or Test-System (Pharmacological Data)

Hartley guinea pig ileal longitudinal muscle strips

Sex

male

Method (Pharmacological Data)

in vitro; ability to restore twitch response to that obtained at supramaximal voltage (serotonin 5-HT4 receptor agonist activity) evaluated; tissue vertically suspended in organ bath filled with Krebs' solution under resting tension of 0.8 g

Further Details (Pharmacological Data)

95 percent O2/5 percent CO2; 32 deg C; twitch responses evoked by transmural electrical stimulation of enteric cholinergic nerves; then voltage reduced to obtain stable submaximal response and title comp. added

Type (Pharmacological Data)

EC50

Value of Type (Pharmacological Data)

19.5 nmol/l

Reference

Suzuki; Ohuchi; Asanuma; Kaneko; Yokomori; Ito; Isobe; Muramatsu

Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 1 p. 29 - 39 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

DNA; examination of

Species or Test-System (Pharmacological Data)

DNA plasmid pBR322

Concentration (Pharmacological Data)

0.05 - 2.5 mmol/l

Method (Pharmacological Data)

in vitro; inhibition of peroxynitrite-induced plasmid DNA strand scission detected by electrophoresis; PBS; three forms of plasmid: supercoiled, open-circular, and linear detected with UV luminometer

Results

electrophoresis pattern; partly inhibited DNA strand breakage

138 of 239

139 of 239

140 of 239

Reference

Nakagawa, Hidehiko; Sumiki, Erika; Takusagawa, Mitsuko; Ikota, Nobuo; Matsushima, Yoshikazu; Ozawa, Toshihiko

Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 2 p. 261 - 265 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

hypotensive

Species or Test-System (Pharmacological Data)

Sprague-Dawley rat

Sex

male

Route of Application

intravenous

Concentration (Pharmacological Data)

< 0.01 - 0.06 μmol/kg

Kind of Dosing (Pharmacological Data)

dissolved in 0.1 ml of alcoholic saline (1 percent EtOH in 0.9 percent NaCl); cumulative doses of title comp. injected via external jugular vein at stable mean arterial blood pressure

Method (Pharmacological Data)

rat weight 260-280 g; 10 rats/group; housed at 21 deg C and 12/12 hr light/dark cycle; maintained on standard rodent chow and water ad lib.; blood pressure measured in left carotid artery; cumulative effect of title comp. accounted

Results

very potent effect at low doses; gentle decrease of blood pressure at higher doses; dose-response curve of the hypotensive effect of title comp. (figure)

Reference

Wang, Hexiang; Ng, Tzi Bun

Pharmacology and Toxicology, 2000 , vol. 86, # 3 p. 125 - 128 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor; binding activity

Species or Test-System (Pharmacological Data)

5-HT6 receptors

Method (Pharmacological Data)

receptors stably transfected to human embryonic kidney 293 cells; binding activity of title comp. determined in competition with 2 nmol/l <3H>lysergic acid diethylamide in Tris buffer (pH 7.4) at 37 deg C for 60 min; liquid scintillation

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

90 nmol/l

Reference

Lee; Rangisetty; Dukat; Slassi; Maclean; Glennon

Medicinal Chemistry Research, 2000 , vol. 10, # 4 p. 230 - 242 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

displacing of 125I-DAIZAC

Species or Test-System (Pharmacological Data)

whole brain membrane of Sprague-Dawley rat

Sex

male

Concentration (Pharmacological Data)

3 - 30 μmol/l

Method (Pharmacological Data)

cell membranes suspn. incubated with title compd. in presence of 3 nM of 125I-DAIZAC; anal. (gamma spectrometry)

Further Details (Pharmacological Data)

125I-DAIZAC - desamino-3-(125)iodo-(S)-zacopride

Results

2 percent displacement of specifically bound 125I-DAIZAC

Reference

Hewlett, William A.; Trivedi, Bakula L.; Zhang, Zhang-Jin; De Paulis, Tomas; Schmidt, Dennis E.; Lovinger, David M.; Ansari, M. Sib; Ebert, Michael H. Journal of Pharmacology and Experimental Therapeutics, 1999 , vol. 288, # 1 p. 221 - 231 Title/Abstract Full Text View citing articles Show Details

141 of 239

Effect (Pharmacological Data)

cardiovascular

Endpoint of Effect (Pharmacological Data)

prolonged decrease in diastolic blood pressure

Species or Test-System (Pharmacological Data)

fawn-hooded rat

Sex

male

Route of Application

intravenous

Concentration (Pharmacological Data)

Ca. 1E-09 - 1E-06 mol/kg

142 of 239

143 of 239

144 of 239

Kind of Dosing (Pharmacological Data)

bolus injection

Method (Pharmacological Data)

250-350 g rats; title comp. was injected via femoral vein; arterial blood flow was monitored at the left carotid artery with continuous display of the heart rate using a rate-meter

Comment (Pharmacological Data)

No effect

Reference

Hardcastle

Journal of Pharmacy and Pharmacology, 1999 , vol. 51, # 12 p. 1415 - 1421 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

cardiovascular

Endpoint of Effect (Pharmacological Data)

prolonged decrease in diastolic blood pressure

Species or Test-System (Pharmacological Data)

Wistar rat

Sex

male

Route of Application

intravenous

Concentration (Pharmacological Data)

Ca. 1E-09 - 1E-06 mol/kg

Kind of Dosing (Pharmacological Data)

bolus injection

Method (Pharmacological Data)

250-300 g rats; title comp. was injected via femoral vein; arterial blood flow was monitored at the left carotid artery with continuous display of the heart rate using a rate-meter

Type (Pharmacological Data)

ED50

Value of Type (Pharmacological Data)

56 nmol/kg

Results

title comp.-induced maximum decrease in diastolic blood pressure was 66 mmHg

Reference

Hardcastle

Journal of Pharmacy and Pharmacology, 1999 , vol. 51, # 12 p. 1415 - 1421 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

cardiovascular

Endpoint of Effect (Pharmacological Data)

increase in systolic blood pressure

Species or Test-System (Pharmacological Data)

Wistar rat

Sex

male

Route of Application

intravenous

Concentration (Pharmacological Data)

Ca. 1E-09 - 1E-06 mol/kg

Kind of Dosing (Pharmacological Data)

bolus injection

Method (Pharmacological Data)

250-300 g rats; title comp. was injected via femoral vein; arterial blood flow was monitored at the left carotid artery with continuous display of the heart rate using a rate-meter

Type (Pharmacological Data)

ED50

Value of Type (Pharmacological Data)

227 nmol/kg

Results

title comp.-induced maximum increase in systolic blood pressure was 75 mmHg

Reference

Hardcastle

Journal of Pharmacy and Pharmacology, 1999 , vol. 51, # 12 p. 1415 - 1421 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

cardiovascular

Endpoint of Effect (Pharmacological Data)

increase in systolic blood pressure

Species or Test-System (Pharmacological Data)

fawn-hooded rat

145 of 239

146 of 239

Sex

male

Route of Application

intravenous

Concentration (Pharmacological Data)

Ca. 1E-09 - 1E-06 mol/kg

Kind of Dosing (Pharmacological Data)

bolus injection

Method (Pharmacological Data)

250-350 g rats; title comp. was injected via femoral vein; arterial blood flow was monitored at the left carotid artery with continuous display of the heart rate using a rate-meter

Type (Pharmacological Data)

ED50

Value of Type (Pharmacological Data)

62 nmol/kg

Results

title comp.-induced maximum increase in systolic blood pressure was 57 mmHg

Reference

Hardcastle

Journal of Pharmacy and Pharmacology, 1999 , vol. 51, # 12 p. 1415 - 1421 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

cardiovascular

Endpoint of Effect (Pharmacological Data)

decrease in heart rate

Species or Test-System (Pharmacological Data)

Wistar rat

Sex

male

Route of Application

intravenous

Concentration (Pharmacological Data)

Ca. 1E-09 - 1E-06 mol/kg

Kind of Dosing (Pharmacological Data)

bolus injection

Method (Pharmacological Data)

250-300 g rats; title comp. was injected via femoral vein; arterial blood flow was monitored at the left carotid artery with continuous display of the heart rate using a rate-meter

Further Details (Pharmacological Data)

estimation of the effect of title comp. on heart rate

Comment (Pharmacological Data)

No effect

Reference

Hardcastle

Journal of Pharmacy and Pharmacology, 1999 , vol. 51, # 12 p. 1415 - 1421 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

cardiovascular

Endpoint of Effect (Pharmacological Data)

decrease in heart rate

Species or Test-System (Pharmacological Data)

fawn-hooded rat

Sex

male

Route of Application

intravenous

Concentration (Pharmacological Data)

Ca. 1E-09 - 1E-06 mol/kg

Kind of Dosing (Pharmacological Data)

bolus injection

Method (Pharmacological Data)

250-350 g rats; title comp. was injected via femoral vein; arterial blood flow was monitored at the left carotid artery with continuous display of the heart rate using a rate-meter

Further Details (Pharmacological Data)

estimation of the effect of title comp. on heart rate

Comment (Pharmacological Data)

No effect

Reference

Hardcastle

Journal of Pharmacy and Pharmacology, 1999 , vol. 51, # 12 p. 1415 - 1421 Title/Abstract Full Text View citing articles Show Details

147 of 239

148 of 239

149 of 239

Effect (Pharmacological Data)

secretion stimulant

Endpoint of Effect (Pharmacological Data)

change in potential difference in proximal colon

Species or Test-System (Pharmacological Data)

Wistar rat

Sex

male

Route of Application

intravenous

Concentration (Pharmacological Data)

Ca. 1E-09 - 1E-06 mol/kg

Kind of Dosing (Pharmacological Data)

bolus injection

Method (Pharmacological Data)

250-300 g rats; 3-cm segment of PC of anesth. rats was tied at the distal end and filled with 154 nM NaCl; title comp. was injected via femoral vein; potential difference across each loop was measured between 2 salt-bridge electrodes

Further Details (Pharmacological Data)

proximal colon (PC); estimation of title comp. effect on transepithelial electrical activity

Type (Pharmacological Data)

ED50

Value of Type (Pharmacological Data)

192 nmol/kg

Results

maximum response induced by title comp. was equal to 4.1 +/- 0.5; graphic representation

Reference

Hardcastle

Journal of Pharmacy and Pharmacology, 1999 , vol. 51, # 12 p. 1415 - 1421 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

secretion stimulant

Endpoint of Effect (Pharmacological Data)

change in potential difference in proximal colon

Species or Test-System (Pharmacological Data)

fawn-hooded rat

Sex

male

Route of Application

intravenous

Concentration (Pharmacological Data)

Ca. 1E-09 - 1E-06 mol/kg

Kind of Dosing (Pharmacological Data)

bolus injection

Method (Pharmacological Data)

250-350 g rats; 3-cm segment of PC of anesth. rats was tied at the distal end and filled with 154 nM NaCl; title comp. was injected via femoral vein; potential difference across each loop was measured between 2 salt-bridge electrodes

Further Details (Pharmacological Data)

proximal colon (PC); estimation of title comp. effect on transepithelial electrical activity

Type (Pharmacological Data)

ED50

Value of Type (Pharmacological Data)

204 nmol/kg

Results

maximum response induced by title comp. was equal to 7.0 +/- 0.8; graphic representation

Reference

Hardcastle

Journal of Pharmacy and Pharmacology, 1999 , vol. 51, # 12 p. 1415 - 1421 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

secretion stimulant

Endpoint of Effect (Pharmacological Data)

change in potential difference in mid-small intestine

Species or Test-System (Pharmacological Data)

fawn-hooded rat

Sex

male

Route of Application

intravenous

Concentration (Pharmacological Data)

Ca. 1E-09 - 1E-09 mol/kg

150 of 239

151 of 239

152 of 239

Kind of Dosing (Pharmacological Data)

bolus injection

Method (Pharmacological Data)

250-350 g rats; 3-cm segment of MSI of anesth. rats was tied at the distal end and filled with 154 nM NaCl; title comp. was injected via femoral vein; potential difference across each loop was measured between 2 salt-bridge electrodes

Further Details (Pharmacological Data)

mid-small intestine (MSI); estimation of title comp. effect on transepithelial electrical activity

Type (Pharmacological Data)

ED50

Value of Type (Pharmacological Data)

70 nmol/kg

Results

maximum response induced by title comp. was equal to 4.1 +/- 0.3; graphic representation

Reference

Hardcastle

Journal of Pharmacy and Pharmacology, 1999 , vol. 51, # 12 p. 1415 - 1421 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

secretion stimulant

Endpoint of Effect (Pharmacological Data)

change in potential difference in mid-small intestine

Species or Test-System (Pharmacological Data)

Wistar rat

Sex

male

Route of Application

intravenous

Concentration (Pharmacological Data)

Ca. 1E-09 - 1E-06 mol/kg

Kind of Dosing (Pharmacological Data)

bolus injection

Method (Pharmacological Data)

250-300 g rats; 3-cm segment of MSI of anesth. rats was tied at the distal end and filled with 154 nM NaCl; title comp. was injected via femoral vein; potential difference across each loop was measured between 2 salt-bridge electrodes

Further Details (Pharmacological Data)

mid-small intestine (MSI); estimation of title comp. effect on transepithelial electrical activity

Type (Pharmacological Data)

ED50

Value of Type (Pharmacological Data)

59 nmol/kg

Results

maximum response induced by title comp. was equal to 3.3 +/- 0.3; graphic representation

Reference

Hardcastle

Journal of Pharmacy and Pharmacology, 1999 , vol. 51, # 12 p. 1415 - 1421 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

muscle contractive

Species or Test-System (Pharmacological Data)

jejunum of Wistar rat

Sex

not specified

Method (Pharmacological Data)

isolated rat jejunum, 3 - 4 cm length; gassed Krebs-Henseleit solution, 37 deg C, title comp. in increasing concn. at 10 min intervals; isotonic transducer, contractions measured; control acetylcholine (1 μmol/l)

Further Details (Pharmacological Data)

experiment was carried out in the presence of ondansetrom (1 μmol/l) - blockade of 5HT3 receptors

Type (Pharmacological Data)

pEC50

Value of Type (Pharmacological Data)

5.33 dimensionless

Reference

Hemedah; Coupar; Mitchelson

British journal of pharmacology, 1999 , vol. 126, # 1 p. 179 - 188 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

agonist

Species or Test-System (Pharmacological Data)

homogenate of guinea-pig ileum

Sex

not specified

153 of 239

154 of 239

155 of 239

Kind of Dosing (Pharmacological Data)

title comp. used in the concn. range of -10 to -6 log mol/l

Method (Pharmacological Data)

phosphate buffer (50 mmol/l) with <3H>-mesulergine (10 nmol/l) and title comp. (at least 5 different concn., quadruplicate) incubated for 10 min at 37 deg C; homogenate added; incubation 60 min at 37 deg C; filtration; LSC of filter

Further Details (Pharmacological Data)

5-HT7 receptor assay; other receptors blocked by masking drugs added prior to first incubation: cinanserin (30 nmol/l), RS 102221 (3 μmol/l), raclopride (1 μmol/l), prazosin (0.1 μmol/l), and yohimbine (0.1 μmol/l)

Results

inhibition of <3H>-mesulergine binding (diagram); pKi = 7.7 to 9.6 (table)

Reference

Hemedah; Coupar; Mitchelson

British journal of pharmacology, 1999 , vol. 126, # 1 p. 179 - 188 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

agonist

Species or Test-System (Pharmacological Data)

membranes of Wistar rats whole brain minus cerebellum

Sex

not specified

Kind of Dosing (Pharmacological Data)

title comp. used in the concn. range ca. -10 to -4.5 log mol/l

Method (Pharmacological Data)

homogenized brain, membrane isolated; phosphate buffer (50 mmol/l) with <3H>-mesulergine (10 nmol/l) and title comp. (13 concn., duplicates) incub. for 10 min at 37 deg C; membrane homogenate added; incub. 60 min at 37 deg C; filtration; LSC of filter

Further Details (Pharmacological Data)

5-HT7 receptor assay; other receptors blocked by masking drugs added prior to first incubation; cinanserin (30 nmol/l), RS 102221 (3 μmol/l), raclopride (1 μmol/l), prazosin (0.1 μmol/l), and yohimbine (0.1 μmol/l)

Results

inhibition of <3H>-mesulergine binding (diagram); pKi = 6.2 to 9.2 (table)

Reference

Hemedah; Coupar; Mitchelson

British journal of pharmacology, 1999 , vol. 126, # 1 p. 179 - 188 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

agonist

Species or Test-System (Pharmacological Data)

rat jejunum

Sex

male

Concentration (Pharmacological Data)

100 μmol/l

Exposure Period (Pharmacological Data)

10 min

Method (Pharmacological Data)

desensitization; Wistar rats, 230-250 g body wt., anaesthetized with 60 mg/kg i.p. sodium pentobarbitone; potential difference (PD), short-circuit current (SCC) and tissue resistance measured across paired sheets of intact and stripped proximal jejunum

Further Details (Pharmacological Data)

37 deg C, 5-HT - 5-hydroxytryptamine

Results

second application of title compound failed to elicit an increase in SCC either in intact or stripped sheets; desensitization to title compound abolished 5-HT response in stripped sheets

Reference

Hardcastle

Journal of Pharmacy and Pharmacology, 1998 , vol. 50, # 5 p. 539 - 547 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

agonist

Species or Test-System (Pharmacological Data)

rat jejunum

Sex

male

Concentration (Pharmacological Data)

100 μmol/l

Kind of Dosing (Pharmacological Data)

jejunum treated with combination of title compound and 1-phenylbiguanide, 100 μM

Exposure Period (Pharmacological Data)

10 min

Method (Pharmacological Data)

Further Details (Pharmacological Data)

37 deg C, 5-HT - 5-hydroxytryptamine

156 of 239

157 of 239

158 of 239

159 of 239

Results

reduced 5-HT-induced increase in SCC in intact sheets and eliminated it in stripped sheets

Reference

Hardcastle

Journal of Pharmacy and Pharmacology, 1998 , vol. 50, # 5 p. 539 - 547 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

agonist

Species or Test-System (Pharmacological Data)

rat jejunum

Sex

male

Concentration (Pharmacological Data)

1E-08 - 0.0001 mol/l

Exposure Period (Pharmacological Data)

10 min

Method (Pharmacological Data)

in vitro; Wistar rats, 230-250 g body wt., anaesthetized with 60 mg/kg i.p. sodium pentobarbitone; potential difference (PD), short-circuit current (SCC) and tissue resistance measured across paired sheets of intact and stripped proximal jejunum

Further Details (Pharmacological Data)

37 deg C

Type (Pharmacological Data)

EC50

Value of Type (Pharmacological Data)

6.3 - 11 μmol/l

Results

induced conc.-dependent increases in SCC, 18.3 μA/cm2 in stripped sheets, 25.1 μA/cm2 in intact sheets

Reference

Hardcastle

Journal of Pharmacy and Pharmacology, 1998 , vol. 50, # 5 p. 539 - 547 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

intracellular cAMP stimulation

Species or Test-System (Pharmacological Data)

murine fibroblasts (LMtk-) cell line

Concentration (Pharmacological Data)

1E-09 - 1E-05 mol/l

Exposure Period (Pharmacological Data)

10 min

Method (Pharmacological Data)

cell line membrane preincubated (HEPES-buffered saline, pH 7.4, 37 deg C, 30 min), then incubated in presence of title compd.

Type (Pharmacological Data)

EC50

Value of Type (Pharmacological Data)

129 nmol/l

Results

affinity const. Ki = 2.2 nM; concn.-dependent stimulation given (diagram)

Reference

Adham, Nika; Zgombick, John M.; Bard, Jonathan

Journal of Pharmacology and Experimental Therapeutics, 1998 , vol. 287, # 2 p. 508 - 514 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

antioxidant

Species or Test-System (Pharmacological Data)

deoxyribose

Concentration (Pharmacological Data)

0.1 - 10 mmol/l

Method (Pharmacological Data)

deoxyribose (dRib) incub. without/with title comp.+FeCl3+H2O2 in phosphate buffer (pH 7.4; 37 deg C; 1 h); thiobarbituric acid reactive products (oxidative degradation of dRib) detected by spectrophotometry

Further Details (Pharmacological Data)

title comp. effect on dRib degradation studied

Results

conc.-dependent inhibition of dRib degradation (graph)

Reference

Sacco, Silvano; Aquilini, Luciano; Ghezzi, Pietro; Pinza, Mario; Guglielmotti, Angelo

European Journal of Pharmacology, 1998 , vol. 343, # 2-3 p. 249 - 255 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

antidote

160 of 239

161 of 239

162 of 239

Species or Test-System (Pharmacological Data)

Balb/C mice

Sex

female

Route of Application

subcutaneous

Concentration (Pharmacological Data)

4.9 mg/kg

Kind of Dosing (Pharmacological Data)

single dose

Method (Pharmacological Data)

18-20 g mice inj. with 160 μg i.p. E. coli lipopolysaccharide (LPS) simultaneously with title comp.; survival rate (SR) assessed daily for 4 d

Further Details (Pharmacological Data)

title comp. effect on SR studied

Results

SR significantly improved (graph)

Reference

Sacco, Silvano; Aquilini, Luciano; Ghezzi, Pietro; Pinza, Mario; Guglielmotti, Angelo

European Journal of Pharmacology, 1998 , vol. 343, # 2-3 p. 249 - 255 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

antagonist

Species or Test-System (Pharmacological Data)

CD-1 mice

Sex

male

Route of Application

subcutaneous

Concentration (Pharmacological Data)

0.02 nmol/kg

Kind of Dosing (Pharmacological Data)

single dose

Method (Pharmacological Data)

18-20 g mice; 30 min after title comp. inj. with 160 μg i.p. E. coli lipopolysaccharide (LPS); serum tumor necrosis factor (TNF measured by ELISA

Further Details (Pharmacological Data)

title comp.effect on LPS-induced TNF studied

Results

LPS-induced TNF inhibited (diagram)

Reference

Sacco, Silvano; Aquilini, Luciano; Ghezzi, Pietro; Pinza, Mario; Guglielmotti, Angelo

European Journal of Pharmacology, 1998 , vol. 343, # 2-3 p. 249 - 255 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

antagonist

Species or Test-System (Pharmacological Data)

human peripheral blood mononuclear cells

Concentration (Pharmacological Data)

1E-09 - 1E-05 mol/l

Kind of Dosing (Pharmacological Data)

single dose

Method (Pharmacological Data)

cells incub. with title comp.+10 ng/ml E. coli lipopolysaccharide (LPS) in RPMI 1640 (4 h); tumor necrosis factor (TNF) in supernatant measured by ELISA

Further Details (Pharmacological Data)

title comp. effect on LPS-induced TNF studied

Results

LPS-induced TNF conc.-dependently inhibited (diagram)

Reference

Sacco, Silvano; Aquilini, Luciano; Ghezzi, Pietro; Pinza, Mario; Guglielmotti, Angelo

European Journal of Pharmacology, 1998 , vol. 343, # 2-3 p. 249 - 255 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

agonist

Species or Test-System (Pharmacological Data)

Chinese hamster ovary FA4 cells

Concentration (Pharmacological Data)

3 μmol/l

Method (Pharmacological Data)

ability of title comp. to activate PLC-mediated IP accumulation studied; cells labeled with 1 μCi/ml myo-<3H>inositol (24 h, 37 deg C) incubated with title comp. for 10 min; mono-, di-, triphosphates of inositol separated by ion exchange chromatography

163 of 239

164 of 239

165 of 239

166 of 239

167 of 239

Further Details (Pharmacological Data)

radioactivity counted by liquid scintillation; cells expressing human 5-HT2A receptors; 5-HT: 5-hydroxytryptamine; PLC: phospholipase C; IP: inositol phosphates; 5-HT used as reference comp.; Emax: maximal response

Results

Emax title comp./Emax 5-HT ca. 0.85 (figure)

Reference

Berg, Kelly A.; Maayani, Saul; Goldfarb, Joseph; Scaramellini, Clare; Leff, Paul; Clarke, William P.

Molecular Pharmacology, 1998 , vol. 54, # 1 p. 94 - 104 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

agonist

Species or Test-System (Pharmacological Data)

Chinese hamster ovary FA4 cells

Concentration (Pharmacological Data)

3 μmol/l

Method (Pharmacological Data)

ability of title comp. to activate PLA2-mediated arachidonic acid release studied; cells labeled with 0.1 μCi/ml <14C>arachidonic acid (4 h, 37 deg C) incubated with title comp. for 10 min; radioactivity measured by liquid scintillation counting

Further Details (Pharmacological Data)

cells expressing human 5-HT2A receptors; 5-HT: 5-hydroxytryptamine; PLA2: phospholipase A2; 5-HT used as reference comp.; Emax: maximal response

Results

Emax title comp./Emax 5-HT ca. 1.30 (figure)

Reference

Berg, Kelly A.; Maayani, Saul; Goldfarb, Joseph; Scaramellini, Clare; Leff, Paul; Clarke, William P.

Molecular Pharmacology, 1998 , vol. 54, # 1 p. 94 - 104 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

agonist

Species or Test-System (Pharmacological Data)

Chinese hamster ovary FA4 cells

Concentration (Pharmacological Data)

3 μmol/l

Method (Pharmacological Data)

ability of title comp. to increase Ca(2+) conc. studied; cells loaded with Fura-2; intracellular Ca(2+) conc. determined by measuring fluorescence (340/380 nm)

Further Details (Pharmacological Data)

cells expressing human 5-HT2A receptors; 5-HT: 5-hydroxytryptamine; 5-HT used as reference comp.; Emax: maximal response

Results

Emax title comp./Emax 5-HT ca. 0.80 (figure)

Reference

Berg, Kelly A.; Maayani, Saul; Goldfarb, Joseph; Scaramellini, Clare; Leff, Paul; Clarke, William P.

Molecular Pharmacology, 1998 , vol. 54, # 1 p. 94 - 104 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

inhibition of 2-<125I>-iodomelatonin binding in membrane preparations of rat testes, IC50>100000 nmol/L

Reference

Vera; Tijmes; Valladares

Steroids, 1997 , vol. 62, # 2 p. 226 - 229 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

acetylcholine release

Species or Test-System (Pharmacological Data)

guinea-pig ileum

Sex

male and female

Concentration (Pharmacological Data)

1E-07 - 0.0001 mol/l

Exposure Period (Pharmacological Data)

15 min

Method (Pharmacological Data)

longitudinal muscle-myenteric plexus preparation; incubation with <3H>choline (7 μCi/ml); superfusion; depolarization with 50 mM KCl at 12 and 45 min after beginning sample collection; drug addition at 30 min; measuring tritium content in superfusate

Further Details (Pharmacological Data)

Tyrode's solution containing 1 μM hemicholinum-3 and 1 μM methysergide; at 37 deg C; 95 percent O2/5 percent CO2

Results

enhancement of <3H>acetyl choline release in concentration-dependent manner

Reference

Ramirez; Garcia-Garayoa; Romero; Monge; Roca; Del Rio; Lasheras

Journal of Pharmacy and Pharmacology, 1997 , vol. 49, # 1 p. 58 - 65 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

antagonist

168 of 239

169 of 239

170 of 239

Endpoint of Effect (Pharmacological Data)

inhibition of increase in neurogenic twitch response

Species or Test-System (Pharmacological Data)

guinea-pig ileum

Sex

male and female

Concentration (Pharmacological Data)

5e-07 mol/l

Exposure Period (Pharmacological Data)

30 min

Method (Pharmacological Data)

longitudinal muscle-myenteric plexus preparation; electrical field stimulation (0.2 Hz, 60 percent maximal voltage); incubation with test compound; treatment with VB20B7 (50 μM); contractions recorded isometrically

Further Details (Pharmacological Data)

in physiological solution (pH 7.4) containing 1 μM methysergide; at 37 deg C; 95 percent O2/5 percent CO2; under 0.5-g tension

Results

inhibited contraction elicited by VB20B7 by 75 percent

Reference

Ramirez; Garcia-Garayoa; Romero; Monge; Roca; Del Rio; Lasheras

Journal of Pharmacy and Pharmacology, 1997 , vol. 49, # 1 p. 58 - 65 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

muscle relaxant

Endpoint of Effect (Pharmacological Data)

relaxation of carbachol-induced tone

Species or Test-System (Pharmacological Data)

Wistar rat oesophageal tunica muscularis mucosae

Sex

male

Method (Pharmacological Data)

contracting rat oesophagus with carbachol (3 μM, 20 min); cumulative addition of test agonist; isometrical recording of response; cumulative concentration-effect curve

Further Details (Pharmacological Data)

in Tyrode's solution (pH 7.4) containing 0.1 mM pargyline, 30 μM cocaine, 30 μM corticosterone and 1 μM methysergide; at 37 deg C; 95 percent O2/5 percent CO2

Results

pEC50 8.08; intrinsic activity (relative to maximal response to 5-HT) 1.20; equipotent concentration ratio (=IC40 test agonist/IC40 5-HT) 0.26

Reference

Ramirez; Garcia-Garayoa; Romero; Monge; Roca; Del Rio; Lasheras

Journal of Pharmacy and Pharmacology, 1997 , vol. 49, # 1 p. 58 - 65 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

agonist

Species or Test-System (Pharmacological Data)

Wistar rat ileum

Sex

male

Concentration (Pharmacological Data)

1E-08 - 0.0001 mol/l

Kind of Dosing (Pharmacological Data)

at desensitization assay: two consecutive application at concn. of 100 μM with 10 min interval

Method (Pharmacological Data)

rats of 230-250 g; paired sheets of intact and stripped ileum; effect of title comp. on potential difference (PD), short-circuit current (SCC) and tissue resistance generated in intact and stripped sheets; repeated application to assess desensitization

Further Details (Pharmacological Data)

incubation in Krebs bicarbonate saline at 37 deg C under 95 percent O2-5 percent CO2; title comp. adding to serosal fluid; serosal fluid contained 10 mM glucose, mucosal fluid contained 10 mM mannitol

Type (Pharmacological Data)

EC50

Value of Type (Pharmacological Data)

3.3 - 20 μmol/l

Results

dose-dependent increase in SCC with maximum of 43.9 and 28.6 μA cm-2 in intact and stripped sheets, resp.; higher affect in stripped sheets; loss of response at 2nd application in stripped sheets, but SCC increase in intact sheets to 45 percent 1st response

Reference

Hardcastle

Journal of Pharmacy and Pharmacology, 1997 , vol. 49, # 11 p. 1114 - 1120 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

muscle contractive

Species or Test-System (Pharmacological Data)

Beagle dog colon longitudinal muscle

171 of 239

172 of 239

173 of 239

Sex

male and female

Concentration (Pharmacological Data)

Ca. 1E-07 - 0.0001 mol/l

Method (Pharmacological Data)

dogs (7-14kg) decerebrated, a piece of midcolon ca. 5 cm dissected, luminal contents removed; mucosa, submucosa and mesenterium dissected, strips of longitudinal muscle prepared; in the presence of (10nM) SB 204070

Further Details (Pharmacological Data)

pEC50 = -log (effective concentration 50)

Type (Pharmacological Data)

pEC50

Value of Type (Pharmacological Data)

5.7 mol/l

Reference

Prins, Nicolaas H.; Briejer, Michel R.; Schuurkes, Jan A.J.

British Journal of Pharmacology, 1997 , vol. 120, # 4 p. 714 - 720 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

muscle contractive

Species or Test-System (Pharmacological Data)

Beagle dog colon longitudinal muscle

Sex

male and female

Concentration (Pharmacological Data)

Ca. 1E-07 - 0.0001 mol/l

Method (Pharmacological Data)

dogs (7-14kg) decerebrated, a piece of midcolon ca. 5 cm dissected, luminal contents removed; mucosa, submucosa and mesenterium dissected, strips of longitudinal muscle prepared

Further Details (Pharmacological Data)

concentration-response curve in the presence of 10 nM SB 204070

Results

concentration-dependent contraction: title compound concentration (logM), ca. contraction percent: -7, 10; -6, 30; -5, 70; -4, 75; slope of concentration-response curve = 0.7+/-0.2

Reference

Prins, Nicolaas H.; Briejer, Michel R.; Schuurkes, Jan A.J.

British Journal of Pharmacology, 1997 , vol. 120, # 4 p. 714 - 720 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor; binding activity

Species or Test-System (Pharmacological Data)

Albino rabbit retina membranes

Method (Pharmacological Data)

ML1 melatonine presynaptic heteroreceptors binding study; membranes suspension (80-100 μg protein/tube) incubated with 2-<125I>-iodomelatonin (80 pmol/l) and title comp. at 25 deg C for 1.5 h

Further Details (Pharmacological Data)

filters counted in a γ-counter; Ki value calculated from IC50 obtained from concentration effects curves; Ki: dissociation constant;

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

27390 nmol/l

Reference

Dubocovich, Margarita L.; Masana, Monica I.; Iacob, Stanca; Sauri, Daniel M.

Naunyn-Schmiedeberg's Archives of Pharmacology, 1997 , vol. 355, # 3 p. 365 - 375 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor; binding activity

Species or Test-System (Pharmacological Data)

COS-7 cells expressing human Mel1b receptors

Method (Pharmacological Data)

COS-7 cells transiently transfected with the human Mel1b cDNAs, then cells were lysed; final suspension concentration: 20-35 μg protein/tube; lysate incubated with 2<125I>-iodomelatonin (80 pmol/l) and title comp. (25 deg C, 1.5 h)

Further Details (Pharmacological Data)

filters counted in a γ-counter; Ki value calculated from IC50 obtained from concentration effects curves; Ki: dissociation constant

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

254000 nmol/l

Reference

Dubocovich, Margarita L.; Masana, Monica I.; Iacob, Stanca; Sauri, Daniel M.

Naunyn-Schmiedeberg's Archives of Pharmacology, 1997 , vol. 355, # 3 p. 365 - 375 Title/Abstract Full Text View citing articles Show Details

174 of 239

175 of 239

176 of 239

177 of 239

Effect (Pharmacological Data)

receptor; binding activity

Species or Test-System (Pharmacological Data)

COS-7 cells expressing human Mel1a receptors

Method (Pharmacological Data)

COS-7 cells transiently transfected with the human Mel1a cDNAs, then cells were lysed; final suspension concentration: 20-35 μg protein/tube; lysate incubated with 2<125I>-iodomelatonin (80 pmol/l) and title comp. (25 deg C, 1.5 h)

Further Details (Pharmacological Data)

filters counted in a γ-counter; Ki value calculated from IC50 obtained from concentration effects curves; Ki: dissociation constant

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

244000 nmol/l

Reference

Dubocovich, Margarita L.; Masana, Monica I.; Iacob, Stanca; Sauri, Daniel M.

Naunyn-Schmiedeberg's Archives of Pharmacology, 1997 , vol. 355, # 3 p. 365 - 375 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

hypotensive

Species or Test-System (Pharmacological Data)

Wistar rat

Sex

male

Route of Application

intravenous

Concentration (Pharmacological Data)

1.7 - 5260 nmol/kg

Kind of Dosing (Pharmacological Data)

title comp. dissolved in saline, administered after raised BP had become stable; each dose of title comp. admin. as single bolus in 1 ml/kg

Method (Pharmacological Data)

in vivo; normotensive rats (350-450 g) anesthet., pithed, artificially respired, bilaterally vagotomized; catheters placed in the left femoral vein (ME infusion), the right femoral vein (title comp. admin.) and the left carotid artery (pressure record.)

Further Details (Pharmacological Data)

diastolic blood pressure (BP), heart rate measured; i.v. 0.18 μmol/kg ketanserin admin. and 10 min later contin. infusion of 60-80 nmol/kg/min methoxamine (ME), BP raised to 110 mm Hg; dose response curve to title comp.; ED50 in mol/kg

Type (Pharmacological Data)

-log ED50

Value of Type (Pharmacological Data)

7.38 dimensionless

Results

title comp. produced clear hypotensive responses, dose-dependent decreases in diastolic BP observed; biphasic hypotensive pattern; initial pressor responses to title comp. were inhibited by increasing conc. of ketanserin to 3.2 μmol/kg (diagram)

Reference

Terron

British journal of pharmacology, 1997 , vol. 121, # 3 p. 563 - 571 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

Accumulation

Species or Test-System (Pharmacological Data)

Hartley guinea pig ileum

Sex

male

Concentration (Pharmacological Data)

10 μmol/l

Method (Pharmacological Data)

pigs (250-300 g) sacrificed by asphyxiation with CO2, ilea dissected, longitudinal muscle removed; incubation with title comp. at 37 degC for 10 min; cAMP accumulation determined by measuring incorporation of (3H)adenine into (3H)ATP

Further Details (Pharmacological Data)

cAMP = cyclic AMP; inhibition by oxotremorine-M further studied

Results

title comp. caused a 1.25-fold increase in cAMP levels compared with control

Reference

Ostrom, Rennolds S.; Ehlert, Frederick J.

Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 280, # 1 p. 189 - 199 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

agonist

Species or Test-System (Pharmacological Data)

Wistar rat distal colonic mucosa

Sex

male

178 of 239

179 of 239

180 of 239

181 of 239

Concentration (Pharmacological Data)

3E-07 - 0.0003 mol/l

Method (Pharmacological Data)

in vitro; short-circuit current (Isc) responses evaluated; preparations mounted in Ussing chamber, bathed on both sides with Krebs-bicarbonate solution equilibrated with 95 percent O2/5 percent CO2 at 37 deg C, short-circuited, and Isc recorded continuously

Further Details (Pharmacological Data)

5-HT used as reference comp.

Type (Pharmacological Data)

EC50

Value of Type (Pharmacological Data)

1.2E-5 mol/l

Results

title comp. conc.-dependently increased Isc and max. response was 80.8 percent of that to 5-HT

Reference

Kiso, Tetsuo; Ito, Hiroyuki; Miyata, Keiji

European Journal of Pharmacology, 1997 , vol. 320, # 2-3 p. 187 - 192 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

peristaltic stimulant

Species or Test-System (Pharmacological Data)

Wistar rat

Sex

male

Route of Application

subcutaneous

Concentration (Pharmacological Data)

3 - 10 mg/kg

Kind of Dosing (Pharmacological Data)

title comp. suspended in a 5 percent arabic gum solution

Method (Pharmacological Data)

feces discharged by three rats 180-210 g collected and weighed 1 hr after administration of title comp.

Further Details (Pharmacological Data)

title comp. affects 5-HT4, 5-HT1-like and 5-HT2 receptors but not 5-HT3 receptors

Results

title comp. dose-dependently increased the fecal pellet output, at 3 mg/kg fecal pellet output (g/3 rats/hr) ca. 1, at 10 mg/kg ca. 1.5, control ca. 0.5

Reference

Ito, Chika; Isobe, Yoshihiko; Kawamura, Reiko; Kiuchi, Yoichi; Tsuchida, Katsuharu; Higuchi, Shohei

Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 280, # 1 p. 67 - 72 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

hypotensive

Species or Test-System (Pharmacological Data)

Wistar rat

Sex

male

Route of Application

intravenous

Concentration (Pharmacological Data)

1 - 30 μg/kg

Kind of Dosing (Pharmacological Data)

used as hydrochloride; dissolved in physiological saline; dose refers to free base

Method (Pharmacological Data)

vagosympathectomized, anaesthetized rats treated with title comp.; BP measured from right carotid artery using pressure transducer; HR measured with tachograph triggered from electrocardiogram signals; BP and HR recorded on polygraph

Further Details (Pharmacological Data)

BP: blood pressure; HR: heart rate

Results

title comp. dose-dependently decreased mean arterial BP, effect lasted for 5-10 min

Reference

De Vries; Villalon; Heiligers; Saxena

Naunyn-Schmiedeberg's archives of pharmacology, 1997 , vol. 356, # 1 p. 90 - 99 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

binding at human 5-HT1A, 5-HT1Dβ and 5-HT1Dα receptors

Reference

Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 314 - 322 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

intrinsic activity and agonist potency in the isolated rat oesophageal tunica muscularis mucosae 1.2 and pEC 50 = 8.1, resp.

182 of 239

183 of 239

184 of 239

185 of 239

Reference

Lasheras, Berta; Berjon, Angel; Montanes, Rafael; Roca, Joan; Romero, Gonzalo; Ramirez, Maria J.; Del Rio, Joaquin

Arzneimittel-Forschung/Drug Research, 1996 , vol. 46, # 4 p. 401 - 406 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

vasodilator, peripheral

Species or Test-System (Pharmacological Data)

jugular vein of Cynomolgus monkey

Sex

not specified

Method (Pharmacological Data)

weight 4-7 kg; endothelium denuded rings; pre-contraction with 10 nM U46619; after 60 min incubation in presence of ketanserin (0.1 μM), pindolol (3 μM), ondansetron (1 μM), GR 113808 (1 μM), phentolamine (1 mM)

Further Details (Pharmacological Data)

pEC50=agonist potency; n=4

Type (Pharmacological Data)

pEC50

Value of Type (Pharmacological Data)

5.7 dimensionless

Results

max. relaxation 54.5 percent of U46619-induced tone; conc.-dependent relaxation

Reference

Leung; Walsh; Pulido-Rios; Eglen

British Journal of Pharmacology, 1996 , vol. 117, # 5 p. 926 - 930 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

vasoconstrictive

Species or Test-System (Pharmacological Data)

jugular vein of Cynomolgus monkey

Sex

not specified

Concentration (Pharmacological Data)

1 - 32000 nmol/l

Method (Pharmacological Data)

weight 4-7 kg; endothelium denuded rings; in absence of spasmogen; in presence of ketanserin (0.1 μM), pindolol (3 μM), ondansetron (1 μM), GR 113808 (1 μM), phentolamine (1 mM)

Comment (Pharmacological Data)

No effect

Reference

Leung; Walsh; Pulido-Rios; Eglen

British Journal of Pharmacology, 1996 , vol. 117, # 5 p. 926 - 930 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

effect on 5-HT levels

Species or Test-System (Pharmacological Data)

rat hippocampus

Sex

female

Concentration (Pharmacological Data)

10 μmol/l

Method (Pharmacological Data)

in vivo study; Wistar rats (150-250 g) anaesthetized, cannulae stereotaxically inserted in cerebral cortex overlaying the hippocampus; after 14 d microdialysis probe inplanted

Further Details (Pharmacological Data)

baseline dialysate 5-HT levels analyzed, title comp. adm. via the microdialysis probe; dialyzate 5-HT levels quantified immediately by HPLC-electrochemical detection; in the continued presence of, and 80 min following methysergide (10 μM) pindolol

Results

enhanced extracellular levels of 5-HT (figure given) approx. 450 percent

Reference

Ge, Jian; Barnes, Nicholas M.

British Journal of Pharmacology, 1996 , vol. 117, # 7 p. 1475 - 1480 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

agonist

Species or Test-System (Pharmacological Data)

Hartley guinea-pig brain slices

Sex

male

Method (Pharmacological Data)

in vitro; slices in Krebs buffer contng. <3H>-5-HT (100 nmol/l for mesencephalic raphe, 20 nmol/l for hippocampus and frontal cortex); 37 deg C, 95 percent O2, 5 percent CO2; electrical stimulation; tritium release by liquid scintillation spectrometry

Further Details (Pharmacological Data)

effect of title comp. (5-HT1D/1B receptor agonist) on the modulation of 5-HT release in mesencephalic raphe, hippocampus and frontal cortex

186 of 239

187 of 239

188 of 239

189 of 239

Results

title comp. inhibited the electrically evoked release of tritium in a concentration-dependent manner

Reference

El Mansari; Blier

British Journal of Pharmacology, 1996 , vol. 118, # 3 p. 681 - 689 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor; binding activity

Species or Test-System (Pharmacological Data)

HEK 293 cells transfected with 5-HT3R-As cDNA

Kind of Dosing (Pharmacological Data)

as hydrochloride

Method (Pharmacological Data)

assay tubes containing 100 μl 3H-granisetron, 100 μl of title comp. and 50 μl of membrane homogenate, total reaction volume 1 ml (37 deg C, 60 min); bound and free radioligand separated by addn. of 3 ml ice cold buffer and immediate vacuum filtration

Results

specific binding remaining in the presence of title comp. = 74+/-2 percent

Reference

Hope, Anthony G.; Peters, John A.; Brown, Angus M.; Lambert, Jeremy J.; Blackburn, Thomas P.

British Journal of Pharmacology, 1996 , vol. 118, # 5 p. 1237 - 1245 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

agonist

Species or Test-System (Pharmacological Data)

human detrusor muscle

Concentration (Pharmacological Data)

10 - 30000 nmol/l

Method (Pharmacological Data)

in vitro; muscular strips in organ bath; isometric transducer; electrical field stimulation (5 Hz for 5 s every min, 0.1 ms pulse duration, 60 V); presence of methylsergide (1 μmol/l) and ondasetron (3 μmol/l); cumulative admin. of title comp.

Further Details (Pharmacological Data)

potentiation of the contractile responses to el. stimulation by title comp. (5-HT4 receptor agonist)

Type (Pharmacological Data)

pEC50

Value of Type (Pharmacological Data)

6.02 dimensionless

Results

concn.-response curve for title comp. (Fig. 2)

Reference

Candura; Messori, Eliana; Franceschetti; D'Agostino; Vicini; Tagliani, Monica; Tonini

British Journal of Pharmacology, 1996 , vol. 118, # 8 p. 1965 - 1970 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor; binding activity

Species or Test-System (Pharmacological Data)

Wistar rats

Sex

male

Method (Pharmacological Data)

whole brain dissected from animals (150-200 g), disrupted, centrifuged, freezed; binding assay at 0, 10, 20, 25, 30, 35 deg C according to Nelson and Thomas method with displacement of <3H>BRL 43694

Further Details (Pharmacological Data)

Ki = inhibitory constant obtained by displacement of 0.6 nM <3H>BRL 43694 from the same receptor

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

6360 - 31810 nmol/l

Results

Ki values (at K):31810 (273), 22730 (283), 12720 (293), 9120 (298), 8180 (303), 6360 (308); thermodynamic data for the binding equilibrium given (Γ0, ΔH0, ΔS0)

Reference

Borea, Pier Andrea; Dalpiaz, Alessandro; Gessi, Stefania; Gilli, Gastone

European Journal of Pharmacology, 1996 , vol. 298, # 3 p. 329 - 334 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

agonist

Species or Test-System (Pharmacological Data)

stripped rat distal colon (Wistar)

Concentration (Pharmacological Data)

0.1 - 100 μmol/l

Method

rats killed by CO2-induced narcosis; distal colon excised and prepared by stripping the muscularis propria and neural ganglia; mounted in Ussing chambers in Krebs

190 of 239

191 of 239

192 of 239

(Pharmacological Data)

soln. pH 7.4, 37 deg C, connected to voltage clamps, subjected to short circuit condition

Further Details (Pharmacological Data)

pretreated with 0.2 μM tetrodotoxin and with tropisetron (0.3,0, and 3 μM) 20 min prior to addition of various concns. of title comp.; title comp.-induced Cl- secretion registered as changes in short circuit current (ΔIsc)

Type (Pharmacological Data)

pA2

Value of Type (Pharmacological Data)

6.4 dimensionless

Results

tropisetron produced dextral shifts in title comp.-induced response curves; at all concns. of tropisetron significant shifts in EC50; Schild plot slope 0.8

Reference

Budhoo, Misra R.; Harris, R. Paul; Kellum, John M.

European Journal of Pharmacology, 1996 , vol. 298, # 2 p. 137 - 140 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

agonist

Species or Test-System (Pharmacological Data)

stripped rat distal colon (Wistar)

Concentration (Pharmacological Data)

0.01 - 100 μmol/l

Method (Pharmacological Data)

rats killed by CO2-induced narcosis; distal colon excised and prepared by stripping the muscularis propria and neural ganglia; mounted in Ussing chambers in Krebs soln. pH 7.4, 37 deg C, connected to voltage clamps, subjected to short circuit condition

Further Details (Pharmacological Data)

pretreated with 0.2 μM tetrodotoxin 20 min prior to addition of title comp. or 5-hydroxytryptamine (5-HT control); title comp.-induced Cl- secretion registered as changes in short circuit current (ΔIsc)

Type (Pharmacological Data)

EC50

Value of Type (Pharmacological Data)

12.0 μmol/l

Results

title comp.-induced a concn.-dependent changes in Isc; maximum response was 99 percent of the 5-HT-induced change in Isc

Reference

Budhoo, Misra R.; Harris, R. Paul; Kellum, John M.

European Journal of Pharmacology, 1996 , vol. 298, # 2 p. 137 - 140 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor; binding activity

Species or Test-System (Pharmacological Data)

cells from colliculi neurons of Swiss mouse embryos

Concentration (Pharmacological Data)

1E-9 - 1E-4 log M

Method (Pharmacological Data)

cells were generated from colliculi of 14-15-day-old Swiss mouse embryos; membrane suspension prepared (pH 7.4, 5 mg protein/ml soln.), incubated with various concns. of title comp. in presence of 0.2 nM (3H)GR 113808 for 30 min at 37 deg C

Further Details (Pharmacological Data)

competition binding expressed as percent of the specific binding in the absence of title comp.; IC50 value required to displace 50 percent of (3H)GR 113808 binding converted to Kd

Type (Pharmacological Data)

pKd

Value of Type (Pharmacological Data)

6.28 dimensionless

Reference

Ansanay; Sebben; Bockaert; Dumuis

European Journal of Pharmacology, 1996 , vol. 298, # 2 p. 165 - 174 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

agonist

Species or Test-System (Pharmacological Data)

cells from colliculi neurons of Swiss mouse embryos

Concentration (Pharmacological Data)

1E-9 - 1E-4 log M

Method (Pharmacological Data)

cells were generated from colliculi of 14-15-day-old Swiss mouse embryos; incubated with increasing concns. of title comp. conversion of (3H)ATP to (3H)cAMP detn. after 5 min at 37 deg C; results expressed as the percent stimulation over basal conversion

Further Details (Pharmacological Data)

EC50 corresponded to the concn. of title comp. required to obtain a half-maximal stimulation of adenylyl cyclase

Type (Pharmacological Data)

pEC50

Value of Type

7 dimensionless

(Pharmacological Data)

193 of 239

194 of 239

195 of 239

196 of 239

Reference

Ansanay; Sebben; Bockaert; Dumuis

European Journal of Pharmacology, 1996 , vol. 298, # 2 p. 165 - 174 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

vasodilator, coronary

Species or Test-System (Pharmacological Data)

coronary artery smooth muscle of dog

Concentration (Pharmacological Data)

1E-07 - 0.001 mol/l

Kind of Dosing (Pharmacological Data)

cumulative doses into organ bath

Method (Pharmacological Data)

precontraction with 2 μM prostaglandin F2α, application of title comp.; measurement of force

Further Details (Pharmacological Data)

mongrel dogs of either sex (weight 15-25 kg); killed; coronary arteries washed, freed of endothelium; segments of arteries 4 mm lengths in Krebs bicarbonate solution stretched to tension of 10 g over 10 min, tested by contraction with 40 μM KCl

Type (Pharmacological Data)

pD2

Value of Type (Pharmacological Data)

4.42 dimensionless

Results

small vasoconstriction at low doses, relaxation at higher doses; pD2 4.58; effects unaltered by pretreatment with 5-HT1D receptor antagonist GR127935

Reference

Terron, Jose A.

British Journal of Pharmacology, 1996 , vol. 118, # 6 p. 1421 - 1428 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor; binding activity

Species or Test-System (Pharmacological Data)

Siberian hamster tissue, melatonin ML2 receptors

Method (Pharmacological Data)

membrane pellets from whole brain or testes incubated in Tris-HCl buffer with 7 conc.s of title comp. at 4 deg C, pH 7.4, for 1 h, competing for binding with 2<125I>MCA-NAT (50 pM)

Further Details (Pharmacological Data)

Ki values from IC50 obtained from competition curves, method Cheng and Prusoff

Results

Ki (nM): 2-<125I>MCA-NAT: brain 641, testes 1926

Reference

Molinari; North; Dubocovich

European Journal of Pharmacology, 1996 , vol. 301, # 1-3 p. 159 - 168 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor; binding activity

Species or Test-System (Pharmacological Data)

h5-HT1Dβ L929sA cells

Method (Pharmacological Data)

radioligand assay; incubation at 37 deg C, for 30 min; radioactivity measured by scintillation; in presence of <3H>5-alniditan (2 nM)

Further Details (Pharmacological Data)

Ki = apparent equilibrium inhibition constant

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

47 nmol/l

Reference

Leysen; Gommeren; Heylen; Luyten; Van De Weyer; Vanhoenacker; Haegeman; Schotte; Van Gompel; Wouters; Lesage

Molecular Pharmacology, 1996 , vol. 50, # 6 p. 1567 - 1580 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor; binding activity

Species or Test-System (Pharmacological Data)

h5-HT1Dβ L929sA cells

Method (Pharmacological Data)

radioligand assay; incubation at 37 deg C, for 30 min; radioactivity measured by scintillation; in presence of <3H>5-HT (4 nM)

Further Details (Pharmacological Data)

Ki = apparent equilibrium inhibition constant

197 of 239

198 of 239

199 of 239

200 of 239

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

9.4 nmol/l

Reference

Leysen; Gommeren; Heylen; Luyten; Van De Weyer; Vanhoenacker; Haegeman; Schotte; Van Gompel; Wouters; Lesage

Molecular Pharmacology, 1996 , vol. 50, # 6 p. 1567 - 1580 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor; binding activity

Species or Test-System (Pharmacological Data)

h5-HT1Dα C6 glioma cells

Method (Pharmacological Data)

radioligand assay; incubation at 37 deg C, for 30 min; radioactivity measured by scintillation; in presence of <3H>5-HT (4 nM)

Further Details (Pharmacological Data)

Ki = apparent equilibrium inhibition constant

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

3.2 nmol/l

Reference

Leysen; Gommeren; Heylen; Luyten; Van De Weyer; Vanhoenacker; Haegeman; Schotte; Van Gompel; Wouters; Lesage

Molecular Pharmacology, 1996 , vol. 50, # 6 p. 1567 - 1580 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor; binding activity

Species or Test-System (Pharmacological Data)

h5-HT1Dα C6 glioma cells

Method (Pharmacological Data)

radioligand assay; incubation at 37 deg C, for 30 min; radioactivity measured by scintillation; in presence of <3H>alniditan (2 nM)

Further Details (Pharmacological Data)

Ki = apparent equilibrium inhibition constant

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

36 nmol/l

Reference

Leysen; Gommeren; Heylen; Luyten; Van De Weyer; Vanhoenacker; Haegeman; Schotte; Van Gompel; Wouters; Lesage

Molecular Pharmacology, 1996 , vol. 50, # 6 p. 1567 - 1580 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor; binding activity

Species or Test-System (Pharmacological Data)

5-HT1D calf substantia nigra

Method (Pharmacological Data)

radioligand assay; incubation at 37 deg C, for 30 min; radioactivity measured by scintillation; in presence of <3H>alniditan (2 nM)

Further Details (Pharmacological Data)

Ki = apparent equilibrium inhibition constant

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

9.6 nmol/l

Reference

Leysen; Gommeren; Heylen; Luyten; Van De Weyer; Vanhoenacker; Haegeman; Schotte; Van Gompel; Wouters; Lesage

Molecular Pharmacology, 1996 , vol. 50, # 6 p. 1567 - 1580 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor; binding activity

Species or Test-System (Pharmacological Data)

5-HT1D calf substantia nigra

Method (Pharmacological Data)

radioligand assay; incubation at 37 deg C, for 30 min; radioactivity measured by scintillation; in presence of <3H>5-HT (4 nM)

Further Details (Pharmacological Data)

Ki = apparent equilibrium inhibition constant

201 of 239

202 of 239

203 of 239

204 of 239

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

3.2 nmol/l

Reference

Leysen; Gommeren; Heylen; Luyten; Van De Weyer; Vanhoenacker; Haegeman; Schotte; Van Gompel; Wouters; Lesage

Molecular Pharmacology, 1996 , vol. 50, # 6 p. 1567 - 1580 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

agonist

Species or Test-System (Pharmacological Data)

Y-1 adrenocortical tumor cells

Method (Pharmacological Data)

recombinant human 5-HT1Dβ receptor subtype stably expressed in cells; potency to inhibit forskolin-stimulated cAMP accumulation; radioimmunoassay

Type (Pharmacological Data)

EC50

Value of Type (Pharmacological Data)

8.1 nmol/l

Reference

Zgombick, John M.; Schechter, Lee E.; Adham, Nika; Kucharewicz, Stefan A.; Weinshank, Richard L.; Branchek, Theresa A.

Naunyn-Schmiedeberg's Archives of Pharmacology, 1996 , vol. 354, # 3 p. 226 - 236 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

agonist

Species or Test-System (Pharmacological Data)

NIH-3T3 fibroblast

Method (Pharmacological Data)

recombinant human 5-HT1Dα receptor subtype stably expressed in fibroblasts; potency to inhibit forskolin-stimulated cAMP accumulation; radioimmunoassay

Type (Pharmacological Data)

EC50

Value of Type (Pharmacological Data)

1.0 nmol/l

Reference

Zgombick, John M.; Schechter, Lee E.; Adham, Nika; Kucharewicz, Stefan A.; Weinshank, Richard L.; Branchek, Theresa A.

Naunyn-Schmiedeberg's Archives of Pharmacology, 1996 , vol. 354, # 3 p. 226 - 236 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor; binding activity

Species or Test-System (Pharmacological Data)

monkey kidney cells

Method (Pharmacological Data)

membranes harvested from cells (Cos-7) transiently expressing gene encoding rabbit 5-HT1Dα (A) or 5-HT1Dβ (B) receptor subtypes; radioligand binding assay; competition experiments with <3H>5-hydroxytryptamine at 37 deg C for 30 min

Type (Pharmacological Data)

pKi

Value of Type (Pharmacological Data)

7.58 - 7.81 dimensionless

Results

pKi for A 7.81, for B 7.58

Reference

Bard, Jonathan A.; Kucharewicz, Stefan A.; Zgombick, John M.; Weinshank, Richard L.; Branchek, Theresa A.; Cohen, Marlene L.

Naunyn-Schmiedeberg's Archives of Pharmacology, 1996 , vol. 354, # 3 p. 237 - 244 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor; binding activity

Species or Test-System (Pharmacological Data)

rat cortex membranes

Method (Pharmacological Data)

membranes incub. with title comp.+<3H>8-hydroxy-N,N-dipropyl-2-aminotetralin in Tris-HCl-containing buffer (pH 7.7; 0-35 deg C; 20-60 min); inhibition of radioligand binding determined by liquid scintillation

Further Details (Pharmacological Data)

parameter of competitive binding (inhibitory binding const., Ki) calculated from IC50 (title comp. conc. displacing 50 percent of radioligand) values; thermodynamic parameters of binding (ΔG0, ΔH0, ΔS0 for 298.15 K) also determined

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

1.62 - 29 nmol/l

205 of 239

206 of 239

207 of 239

208 of 239

Results

single-site binding; ΔG0=-44.6 KJ/mol; ΔH0=-65 KJ/mol; ΔS0=-67 J/T(K)*mol

Reference

Dalpiaz, Alessandro; Borea, Pier Andrea; Gessi, Stefania; Gilli, Gastone

European Journal of Pharmacology, 1996 , vol. 312, # 1 p. 107 - 114 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

vasoconstrictive

Species or Test-System (Pharmacological Data)

jejunum from Hooded Wister rat

Concentration (Pharmacological Data)

0.003 - 100 μmol/l

Method (Pharmacological Data)

tissue from 200-250 g male rats incub. with title comp.+tetrodotoxin in Krebs-Henseleit sol. (O2:CO2=95:5; 37 deg C; 10 min); isotonic contractions measured with transducer

Further Details (Pharmacological Data)

conc.-response curve (CRC) obtained cumulatively; Emax: max. response expressed as percent of max. response to 1 μM acetylcholine; pEC50=-logEC50: potency

Results

conc.-dependent contractions with monophasic CRC; Emax=83.2 percent; pEC50=6.95 (graph)

Reference

McLean, Peter G.; Coupar, Ian M.

European Journal of Pharmacology, 1996 , vol. 312, # 2 p. 215 - 225 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

inhibition of binding to receptor

Species or Test-System (Pharmacological Data)

human 5-HT1B receptor

Method (Pharmacological Data)

C6-glial cells (CCL 107, rat), ATCC, stably transfected with pcDNA3/5-HT1B plasmid; cellular membranes prepared; radioligand binding with 0.5 nM <3H>-5carboxamidotryptamine in presence of title comp., 25 deg C, 30 min

Further Details (Pharmacological Data)

5-HT=serotonin

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

2.18 nmol/l

Reference

Pauwels; Palmier; Wurch; Colpaert

Naunyn-Schmiedeberg's Archives of Pharmacology, 1996 , vol. 353, # 2 p. 144 - 156 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

inhibition of nucleotide formation

Species or Test-System (Pharmacological Data)

human 5-HT1B receptor

Method (Pharmacological Data)

C6-glial cells (CCL 107, rat), ATCC, stably transfected with pcDNA3/5-HT1B plasmid; incub. with 100 μM forskolin plus title comp., 37 deg C, 5 min; cellular cAMP content by radioimunoassay

Further Details (Pharmacological Data)

EC50: conc. of title comp. yielding 50 percent of the inhibition by 1 μM serotonin (5-HT)

Type (Pharmacological Data)

EC50

Value of Type (Pharmacological Data)

21.00 nmol/l

Reference

Pauwels; Palmier; Wurch; Colpaert

Naunyn-Schmiedeberg's Archives of Pharmacology, 1996 , vol. 353, # 2 p. 144 - 156 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

inhibition of nucleotide formation

Species or Test-System (Pharmacological Data)

human 5-HT1D receptor

Method (Pharmacological Data)

C6-glial cells (CCL 107, rat), ATCC, stably transfected with pRcRSV/5-HT1D plasmid; incub. with 100 μM forskolin plus title comp., 37 deg C, 5 min; cellular cAMP content by radioimunoassay

Further Details (Pharmacological Data)

EC50: conc. of title comp. yielding 50 percent of the inhibition by 1 μM serotonin (5-HT)

Type (Pharmacological Data)

EC50

Value of Type

0.97 nmol/l

(Pharmacological Data)

209 of 239

210 of 239

211 of 239

212 of 239

Reference

Pauwels; Palmier; Wurch; Colpaert

Naunyn-Schmiedeberg's Archives of Pharmacology, 1996 , vol. 353, # 2 p. 144 - 156 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

inhibition of nucleotide formation

Species or Test-System (Pharmacological Data)

human 5-HT1D receptor

Method (Pharmacological Data)

C6-glial cells (CCL 107, rat), ATCC, stably transfected with pcDNA3/5-HT1D plasmid; incub. with 100 μM forskolin plus title comp., 37 deg C, 5 min; cellular cAMP content by radioimunoassay

Further Details (Pharmacological Data)

EC50: conc. of title comp. yielding 50 percent of the inhibition by 1 μM serotonin (5-HT)

Type (Pharmacological Data)

EC50

Value of Type (Pharmacological Data)

4.90 nmol/l

Reference

Pauwels; Palmier; Wurch; Colpaert

Naunyn-Schmiedeberg's Archives of Pharmacology, 1996 , vol. 353, # 2 p. 144 - 156 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

inhibition of binding to receptor

Species or Test-System (Pharmacological Data)

human 5-HT1D receptor

Method (Pharmacological Data)

C6-glial cells (CCL 107, rat), ATCC, stably transfected with pcDNA3/5-HT1D plasmid; cellular membranes prepared; radioligand binding with 3 nM <3H>-sumatriptan in presence of title comp., 25 deg C, 30 min

Further Details (Pharmacological Data)

5-HT=serotonin

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

1.65 nmol/l

Reference

Pauwels; Palmier; Wurch; Colpaert

Naunyn-Schmiedeberg's Archives of Pharmacology, 1996 , vol. 353, # 2 p. 144 - 156 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

inhibition of binding to receptor

Species or Test-System (Pharmacological Data)

human 5-HT1D receptor

Method (Pharmacological Data)

C6-glial cells (CCL 107, rat), ATCC, stably transfected with pcDNA3/5-HT1D plasmid; cellular membranes prepared; radioligand binding with 0.5 nM <3H>-5carboxamidotryptamine (5-CT) in presence of title comp., 25 deg C, 30 min

Further Details (Pharmacological Data)

5-HT=serotonin

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

1.33 nmol/l

Reference

Pauwels; Palmier; Wurch; Colpaert

Naunyn-Schmiedeberg's Archives of Pharmacology, 1996 , vol. 353, # 2 p. 144 - 156 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

inhibition of binding to receptor

Species or Test-System (Pharmacological Data)

human 5-HT1D receptor

Method (Pharmacological Data)

C6-glial cells (CCL 107, rat), ATCC, stably transfected with pRcRSV/5-HT1D plasmid; cellular membranes prepared; radioligand binding with <3H>-5carboxamidotryptamine in presence of title comp., 25 deg C, 30 min

Further Details (Pharmacological Data)

5-HT=serotonin

Type (Pharmacological Data)

1.38 nmol/l

Value of Type (Pharmacological Data)

213 of 239

214 of 239

215 of 239

216 of 239

Reference

Pauwels; Palmier; Wurch; Colpaert

Naunyn-Schmiedeberg's Archives of Pharmacology, 1996 , vol. 353, # 2 p. 144 - 156 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

antagonist

Species or Test-System (Pharmacological Data)

rat Cos-7 cells

Concentration (Pharmacological Data)

1E-09 - 0.0001 mol/l

Method (Pharmacological Data)

the affinity of title comp. that compete for <3H>GR113808 binding at the cloned 5-HT4L receptor was measured; membranes were incubated with 0.4 nmol/l <3H>GR113808 for 30 min at 37 deg C

Further Details (Pharmacological Data)

affinity values are given as Kis, were determined from IC50 values

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

401 nmol/l

Reference

Adham, Nika; Gerald, Christophe; Schechter, Lee; Vaysse, Pierre; Weinshank, Richard; Branchek, Theresa

European Journal of Pharmacology, 1996 , vol. 304, # 1-3 p. 231 - 235 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

antagonist

Species or Test-System (Pharmacological Data)

rat Cos-7 cells

Concentration (Pharmacological Data)

1E-08 - 1E-05 mol/l

Method (Pharmacological Data)

the affinity of title comp. that compete for <3H>5-HT binding at the cloned 5-HT4L receptor was measured; membranes were incubated with 10 nmol/l <3H>5-HT for 30 min at 37 deg C

Further Details (Pharmacological Data)

affinity values are given as Kis, were determined from IC50 values

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

112 nmol/l

Reference

Adham, Nika; Gerald, Christophe; Schechter, Lee; Vaysse, Pierre; Weinshank, Richard; Branchek, Theresa

European Journal of Pharmacology, 1996 , vol. 304, # 1-3 p. 231 - 235 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

muscle contractive

Species or Test-System (Pharmacological Data)

Wistar rat stomach

Sex

male

Concentration (Pharmacological Data)

1E-09 - 1E-05 mol/l

Kind of Dosing (Pharmacological Data)

title comp. was dissolved in Tyrode solution

Method (Pharmacological Data)

stomach fundus strips incubated with <M-3H>CC for 60 min and then superfused (1 ml/min) with Tyrode containing H-3; title comp. added 5 min after start; superfusates collected; radioactivity determined by LSS; contractility recorded isometrically

Further Details (Pharmacological Data)

contractile activity and <3H> outflow determined simultaneously; H-3: hemicholinium-3; <M-3H>CC: <methyl-3H>choline chloride; LSS: liquid scintillation spectrometer; further investigations with tetrodotoxin, atropine or SDZ 205-557

Results

title comp. increased contractions in conc.-dependent manner and evoked <3H>acetylcholine release in a 'bell-shaped' manner with maximum stimulation at 1E-7 mol/l; effects were decreased by tetrodotoxin and SDZ 205-557; atropine inhibited contraction

Reference

Amemiya, Norihito; Hatta, Shinichi; Takemura, Haruo; Ohshika, Hideyo

European Journal of Pharmacology, 1996 , vol. 318, # 2-3 p. 403 - 409 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

muscle contractive

Species or Test-System

Wistar rat stomach

(Pharmacological Data)

217 of 239

218 of 239

219 of 239

220 of 239

Sex

male

Concentration (Pharmacological Data)

1E-09 - 1E-05 mol/l

Kind of Dosing (Pharmacological Data)

title comp. was dissolved in Tyrode solution

Method (Pharmacological Data)

stomach fundus strips placed in organ bath with Tyrode; tension 2 g applied to strips; 60 min later pretreatment with 1 μmol/l atropine for 5 min; incubation with title comp. for 10 min in presence of atropine; contractility recorded isometrically

Results

contractile response to title comp. (1E-8 - 1E-6) was reduced in presence of atropine

Reference

Amemiya, Norihito; Hatta, Shinichi; Takemura, Haruo; Ohshika, Hideyo

European Journal of Pharmacology, 1996 , vol. 318, # 2-3 p. 403 - 409 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

muscle contractive

Species or Test-System (Pharmacological Data)

Wistar rat stomach

Sex

male

Concentration (Pharmacological Data)

0.1 μmol/l

Kind of Dosing (Pharmacological Data)

title comp. was dissolved in Tyrode solution

Method (Pharmacological Data)

stomach fundus strips placed in organ bath with Tyrode; tension 2 g applied; 60 min later 1 μmol/l atropine (ATR) added for 5 min; incubation with title comp. for 10 min in presence of atropine; contractility recorded isometrically

Further Details (Pharmacological Data)

further invest. with (1 μmol/l each) ATR/tetrodotoxin (TTX), ATR/SDZ 205-557 (SDZ, 5-HT4 receptor antagonist), ATR/TTX/SDZ, ATR/yohimbine (YOH, 5-HT2B receptor antagonist), ATR/TTX/YOH or ATR/SDZ/YOH

Results

contractile response to title comp. was reduced in presence of ATR, ATR/TTX, ATR/SDZ or ATR/YOH but in presence of TTX contraction was further inhibited by YOH but not SDZ; title comp. as believe involves ATR-sensitive and ATR-resistant components

Reference

Amemiya, Norihito; Hatta, Shinichi; Takemura, Haruo; Ohshika, Hideyo

European Journal of Pharmacology, 1996 , vol. 318, # 2-3 p. 403 - 409 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

muscle contractive

Species or Test-System (Pharmacological Data)

Wistar rat stomach

Sex

male

Concentration (Pharmacological Data)

0.1 μmol/l

Kind of Dosing (Pharmacological Data)

title comp. was dissolved in Tyrode solution

Method (Pharmacological Data)

stomach fundus strips placed in organ bath with Tyrode; tension 2 g applied; electrical stimulation (ES) for 4 min; SDZ added for 10 min; incubation with title comp. for 10 min in presence of SDZ; ES repeated; contractility recorded isometrically

Further Details (Pharmacological Data)

ES: 45 V, 5 Hz, 5-ms pulse duration, for 5 s, intervals 30 s; SDZ: SDZ 205-557, 1 μmol/l (SDZ, 5-HT4 receptor antagonist); further invest. with 1 μmol/l yohimbine (YOH, 5-HT2B receptor antagonist)

Results

title comp. alone enhanced electrically evoked contractions by 40 percent of control but this stimulatory effect was antagonized by SDZ and YOH

Reference

Amemiya, Norihito; Hatta, Shinichi; Takemura, Haruo; Ohshika, Hideyo

European Journal of Pharmacology, 1996 , vol. 318, # 2-3 p. 403 - 409 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

effect on the transintestinal electrical activity of rat small intestine and colon in-vivo

Reference

Hardcastle

Journal of Pharmacy and Pharmacology, 1995 , vol. 47, # 9 p. 744 - 749 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

muscle relaxant

Species or Test-System (Pharmacological Data)

Dunkin-Hartley guinea-pig ileum

Sex

male

Method

250-350 g pigs killed, ileal segments suspended in Krebs solution + (μM) cocaine 10, corticosterone 10, pargyline 5, indomethacin 1, atropine 1 at 37 deg C, pH 7.4;

(Pharmacological Data)

H: without/with desensitization by 60 min equilibr. with 3 μM 5-carboxamidotryptamine

Further Details (Pharmacological Data)

contractions induced by 1 μM histamine (H) or 30 nM substance P (SP) for 30 s, 5 min dose-cycle; when stable contractions, title comp. added 3 min before spasmogen; change in isometric tension recorded

Results

concentration-dependent relaxation; contraction by H: pEC50: < 4.5; desens.: no effect; SP: pEC50: 5.7, relaxation: 43 percent

Reference

Carter; Champney; Hwang; Eglen

European Journal of Pharmacology, 1995 , vol. 280, # 3 p. 243 - 250 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

electrophysiological

Species or Test-System (Pharmacological Data)

neurons of guinea pig ileum

Sex

male

Concentration (Pharmacological Data)

0.1 - 3 μmol/l

Method (Pharmacological Data)

small piece longitudinal muscle-myenteric plexus pinned out flat and superfused with oxygenated Krebs-bicarbonate solution with 1 μM nifedipine and 1 μM scopolamine; Grass S44 stimulator; intracellular recordings obtained using amplifier Axoclamp 2A

Further Details (Pharmacological Data)

glass electrode filled with Krebs solution was used to evoke slow excitatory postsynaptic potentials (EPSP); stimulating electrode positioned on an interganglionic nerve strand; cumulative addition of title compound

Type (Pharmacological Data)

IC50

Value of Type (Pharmacological Data)

0.4 μmol/l

Results

caused concentration-dependent membrane depolarization in 6 of 9 neurons; conc.-dependent inhibition of spike afterhyperpolarization

Reference

Pan, Hui; Galligan, James J.

European Journal of Pharmacology, 1995 , vol. 278, # 1 p. 67 - 74 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

receptor; binding activity

Species or Test-System (Pharmacological Data)

calf striatum homogenate

Exposure Period (Pharmacological Data)

30 min

Method (Pharmacological Data)

radioligand binding assay; 37 deg C; liquid scintillation counter analysis in ecoscint cocktail

Further Details (Pharmacological Data)

affinity to bovine 5-HT1D receptors

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

4.1 nmol/l

Reference

Hong, Seoung-Soo; Dukat, Malgorzata; Teitler, Milt; Herrick-Davis, Kathy; McCallum, Kirk; et al.

Medicinal Chemistry Research, 1995 , vol. 5, # 9 p. 690 - 699 Title/Abstract Full Text Show Details

Effect (Pharmacological Data)

receptor; binding activity

Species or Test-System (Pharmacological Data)

human 5-HT1Dβ receptors, cloned

Exposure Period (Pharmacological Data)

30 min

Method (Pharmacological Data)

radioligand binding assay; membrane homogenates from cells transfected with human 5-HT1Dβ genes; receptors labeled with 2 nM (3H)serotonin; 37 deg C

Further Details (Pharmacological Data)

liquid scintillation counter analysis in ecoscint cocktail

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

3.5 nmol/l

Reference

Hong, Seoung-Soo; Dukat, Malgorzata; Teitler, Milt; Herrick-Davis, Kathy; McCallum, Kirk; et al.

Hide facts 221 of 239

222 of 239

223 of 239

Medicinal Chemistry Research, 1995 , vol. 5, # 9 p. 690 - 699 Title/Abstract Full Text Show Details

224 of 239

225 of 239

226 of 239

227 of 239

228 of 239

Effect (Pharmacological Data)

receptor; binding activity

Species or Test-System (Pharmacological Data)

human 5-HT1A receptors, cloned

Exposure Period (Pharmacological Data)

30 min

Method (Pharmacological Data)

radioligand binding assay; membrane homogenates from cells transfected with human 5-HT1A genes; receptors labeled with 0.2 nM (3H)-8-OH DPAT; 37 deg C

Further Details (Pharmacological Data)

liquid scintillation counter analysis in ecoscint cocktail

Type (Pharmacological Data)

Value of Type (Pharmacological Data)

3.2 nmol/l

Reference

Hong, Seoung-Soo; Dukat, Malgorzata; Teitler, Milt; Herrick-Davis, Kathy; McCallum, Kirk; et al.

Medicinal Chemistry Research, 1995 , vol. 5, # 9 p. 690 - 699 Title/Abstract Full Text Show Details

Effect (Pharmacological Data)

receptor; binding activity

Species or Test-System (Pharmacological Data)

guinea-pig ileum

Sex

male

Method (Pharmacological Data)

Hartley guinea-pig, distal ileum isolated, mucosal segments prepared, tissues bathed in Ussing system for measurement of short-circuit current, title comp., methysergide and 5-HT added, concentration-response curve measured

Results

title comp. alone stimulatd short-circuit current; title comp. mimicked only the high potency 5-HT response in the presence of methysergide

Reference

Leung; Blissard; Jett; Eglen

Naunyn-Schmiedeberg's Archives of Pharmacology, 1995 , vol. 351, # 6 p. 596 - 602 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

agonist

Species or Test-System (Pharmacological Data)

rat C6-glial cells expressing human 5-HT1Dβ receptor

Concentration (Pharmacological Data)

1E-10 - 1E-05 mol/l

Method (Pharmacological Data)

in vitro; inhibition of forskolin-stimulated cAMP formation evaluated; 100 μmol/l forskolin; 1 mmol/l isobutylmethylxanthine; controlled salt solution, pH 7.4; humidified 95 percent air/5 percent CO2; 37 deg C; incubated for 5 min

Further Details (Pharmacological Data)

cellular cAMP content assayed using RIA; EC50: conc. yielding 50 percent of inhibition of forskolin-induced cAMP formation produced by 1 μmol/l 5-HT; Emax: max. percent inhibition of forskolin-induced cAMP formation vs. that obtained with 1 μmol/l 5-HT

Type (Pharmacological Data)

EC50

Value of Type (Pharmacological Data)

21.0 nmol/l

Results

Emax: 99 percent (conc.-response curve)

Reference

Pauwels, Petrus J.; Colpaert, Francis C.

Biochemical Pharmacology, 1995 , vol. 50, # 10 p. 1651 - 1658 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

affinity and selectivity in 5-HT2A and 5-HT2C serotonin receptor binding

Reference

Glennon; Dukat; El-Bermawy; Law; De los Angeles; Teitler; King; Herrick-Davis

Journal of Medicinal Chemistry, 1994 , vol. 37, # 13 p. 1929 - 1935 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

antifouling activity

Reference

Kon-Ya, Kazumi; Shimidzu, Nobuyoshi; Miki, Wataru; Endo, Mamoru

Bioscience, Biotechnology, and Biochemistry, 1994 , vol. 58, # 12 p. 2178 - 2181 Title/Abstract Full Text Show Details

229 of 239

230 of 239

231 of 239

232 of 239

233 of 239

234 of 239

235 of 239

236 of 239

237 of 239

238 of 239

239 of 239

Comment (Pharmacological Data)

receptor binding affinities (pKl) for 6 subtypes of serotonin/tryptamin receptors: 5-HT1A: 8.42; 5-HT1B: 7.98; 5-HT1C: 8.15; 5-HT1D: 8.30; 5-HT2: 5.77; 5-HT3: 5.40; tryptamine: 6.48.

Reference

Dijkstra, Gerard D. H.; Tulp, Martin Th. M.; Hermkens, Pedro H. H.; Maarseveen, Jan H. van; Scheeren, Hans W.; Kruse, Chris G.

Recueil des Travaux Chimiques des Pays-Bas, 1993 , vol. 112, # 2 p. 131 - 136 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

binding activity at 5-HT2 type receptors, IC50: 11 (5-HT1A), 49 (5-HT1D), 250 (5-HT1C), 130 (5-HT2(DOI)), 1800 (5-HT2(ket)) nM

Reference

Macor; Fox; Johnson; Koe; Lebel; Zorn

Journal of Medicinal Chemistry, 1992 , vol. 35, # 20 p. 3625 - 3632 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

binding affinities at <3H>ketanserin- or <3H>-DOB-labeled 5-HT2 serotonin receptors in brains of male Sprauge-Dawley rats: Ki

Reference

Glennon, Richard A.; Chaurasia, Chandra; Titeler, Milt

Journal of Medicinal Chemistry, 1990 , vol. 33, # 10 p. 2777 - 2784 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

Serotonergic agonist of central serotonin (5-HT) binding sites.

Reference

Glennon; Titeler; Lyon; Slusher

Journal of Medicinal Chemistry, 1988 , vol. 31, # 4 p. 867 - 870 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

ability to display <3H>ketanserin and <3H>serotonin from rat brain frontal cortex homogenate as an indication of affinity for 5-HT2 and 5HT1B receptors, (pKi = 5.99; 8.19), respectively

Reference

Nichols; Lloyd; Johnson; Hoffman

Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1406 - 1412 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

hypoglycemic activity: dose 300 mg/kg (rat, orally)

Reference

Grin, L. M.; Khlaponina, L. N.; Pivnenko, N. S.; Selichenko, A. G.; Brutov, V. D.

Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 7 p. 476 - 479 Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 7 p. 819 - 822 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

Ld 50: 102.5 mg/kg, intravenously (mouse); spasmogenic activity (isolated uterus horn of rat); hypertensic activity; causes contraction of the third eyelid, constricts the ear vessels (rabbit)

Reference

Partsvaniya, D. A.; Akhvlediani, R. N.; Gordeev, E. N.; Vigdorchik, M. M.; Kuleshova, L. N.; et al.

Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 12 p. 833 - 838 Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 12 p. 1454 - 1459 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

causes flabbiness, hyperthermia, tremor, and diarrhea, intensify the activity of hexenal, and weaken the hyperthermic activity of phenamine, subcutaneously (mouse); prolongation of the duration of the soporific activity of hexenal

Reference

Partsvaniya, D. A.; Akhvlediani, R. N.; Gordeev, E. N.; Vigdorchik, M. M.; Kuleshova, L. N.; et al.

Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 12 p. 833 - 838 Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 12 p. 1454 - 1459 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

LD50=2.3 mM, Rhopalosiphum maidis

Reference

Corcuera, Luis J.

Phytochemistry (Elsevier), 1984 , vol. 23, # 3 p. 539 - 542 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

inhib. of pituitary and hypothalamic progesterone 5α-reductase activity of female Holtzman rat

Reference

Krause; Halls; Karavolas

Steroids, 1980 , vol. 36, # 3 p. 305 - 320 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

Zum Metabolismus in vitro durch Rattenleber-homogenate

Reference

Iskric; Kveder

Croatica Chemica Acta, 1965 , vol. 37, p. 233 Full Text Show Details

Ecotoxicology (2)

1 of 2

2 of 2

Effect (Ecotoxicology)

enzyme; inhibition of

Species or Test-System (Ecotoxicology)

purified AChE of Electrophorus electricus, electric eel

Method (Ecotoxicology)

substrate (o-NAA) was incub. at 37 deg C, 1 h in potassium phosphate buffer (0.1 mol/l), pH 8.0, containing 0.15-0.25 U of AChE in presence of title comp.; reaction stopped; AChE associated AAA activity was measured by spectrophotometer at 410 nm

Further Details (Ecotoxicology)

AAA: aryl acylamidase; AChE: acetylcholineesterase; o-NAA: 2'-nitroacetanilide

Type (Ecotoxicology)

IC50

Value of Type (Ecotoxicology)

> 1000 μmol/l

Reference

Costagli, Chiara; Galli, Alessandro

Biochemical Pharmacology, 1998 , vol. 55, # 10 p. 1733 - 1737 Title/Abstract Full Text View citing articles Show Details

Effect (Ecotoxicology)

receptor; binding activity

Species or Test-System (Ecotoxicology)

quail (Coturnix coturnix)

Sex

male and female

Exposure Period (Ecotoxicology)

50 min

Method (Ecotoxicology)

quails, 8-10 week old, decapitated; hearts dissected; fresh heart tissues homogenized in Tris-HCl; 2.0-2.5 mg/ml heart membrane incubated with 22-30 pM <125I>iodomelatonin and title comp. at 37 deg C

Further Details (Ecotoxicology)

radioligand binding assay; radioactivity was determined by gamma counter; Ki: inhibition constant

Type (Ecotoxicology)

Value of Type (Ecotoxicology)

> 10000 nmol/l

Reference

Pang; Tang; Song; Brown

Life Sciences, 1996 , vol. 58, # 13 p. 1047 - 1057 Title/Abstract Full Text View citing articles Show Details

Other Data Use (6) Laboratory Use and Handling

Use Pattern

Reference

active ingredient of a liposomal topical formulation

GUILFORD, F., Timothy

Patent: WO2008/36979 A2, 2008 ;

itching

GUILFORD, F., Timothy

Patent: WO2008/36979 A2, 2008 ;

Title/Abstract Full Text Show Details

histamine and non-histamine related inflammatory skin changes

GUILFORD, F., Timothy

Patent: WO2008/36979 A2, 2008 ;

Comparative compound for investigation of inhibition of lipid peroxidation

Board of Trustees of Michigan State University

Patent: US2005/59727 A1, 2005 ;

used as inhibitor in reaction of peroxidation of 1-stearoyl 2-linoleoyl sn-glycerol 3phosphocholine induced by FeCl2*4H2O

Jayaprakasam, Bolleddula; Strasburg, Gale A.; Nair, Muraleedharan G.

Tetrahedron, 2004 , vol. 60, # 13 p. 3109 - 3121 Title/Abstract Full Text View citing articles Show Details

inhibitory activity on nitration (IC50 0.44 mM) of L-tyrosine to 3-nitrotyrosine (37 deg C, 10 min, pH 7.4); enhancement of oxidation of L-tyrosine to 2,2'-dityrosine

Nakagawa, Hidehiko; Sumiki, Erika; Takusagawa, Mitsuko; Ikota, Nobuo; Matsushima, Yoshikazu; Ozawa, Toshihiko

Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 2 p. 261 - 265 Title/Abstract Full Text View citing articles Show Details

Reaxys Registry Number: 25679244

Title/Abstract Full Text Show Details

no reactions.

Bioactivity (1)

CAS Registry Number: 137375-67-8 Molecular Formula: C11H14N2O*H Linear Structure Formula: C11H14N2O*H(1+)

Molecular Weight: 191.253

InChI Key: JTEJPPKMYBDEMY-UHFFFAOYSA-O

Synthesize | Hide Details Find similar

Bioactivity Pharmacological Data (1) 1 of 1

Comment (Pharmacological Data)

Bioactivities present

Reference

Vermeulen, Erik S.; Schmidt, Anne W.; Sprouse, Jeffrey S.; Wikstroem, Hakan V.; Grol, Cor J.

Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5365 - 5374 Title/Abstract Full Text View citing articles Show Details

Pratuangdejkul; Schneider; Jaudon; Rosilio; Baudoin; Loric; Conti; Launay; Manivet

Current Medicinal Chemistry, 2005 , vol. 12, # 20 p. 2393 - 2410 Title/Abstract Full Text View citing articles Show Details

Chemical Name: 5-methoxytryptamine-α,α,β,β-d4

Reaxys Registry Number: 482899

CAS Registry Number: 96236-05-4 Type of Substance: heterocyclic Molecular Formula: C11H14N2O Linear Structure Formula: C11H10D4N2O Molecular Weight: 194.213

InChI Key: JTEJPPKMYBDEMY-CQOLUAMGSA-N

Synthesize | Hide Details Find similar Chemical Names and Synonyms 5-methoxytryptamine-α,α,β,β-d4, 5-Methoxy-(α,α,β,β-2H(4))-tryptamin, 5-Methoxy-(α,α,β,β-D4)-tryptamin Identification Substance Label (3) Label

Reference

2-d&4%

Gynther, Jukka; Peura, Pekka; Salmi, Seija

Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1985 , vol. 39, # 10 p. 849 - 860 Title/Abstract Full Text Show Details

Beck; Bosin

Biomedical Mass Spectrometry, 1979 , vol. 6, p. 19,20 Full Text Show Details

Shaw; Wright; Milne

Biomedical mass spectrometry, 1977 , vol. 4, # 6 p. 348 - 353 Title/Abstract Full Text View citing articles Show Details

Derivative (2)

5 prep out of 5 reactions.

Identification Physical Data (2) Spectra (3)

Comment (Derivative)

Reference

Pentafluorpropionylderivat: MS

Beck; Bosin

Biomedical Mass Spectrometry, 1979 , vol. 6, p. 19,20 Full Text Show Details

Hydrochlorid: F:235-240grad

Shaw; Wright; Milne

Biomedical mass spectrometry, 1977 , vol. 4, # 6 p. 348 - 353 Title/Abstract Full Text View citing articles Show Details

Physical Data Melting Point (2) Melting Point

Reference

118 - 121 °C

Gynther, Jukka; Peura, Pekka; Salmi, Seija

Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1985 , vol. 39, # 10 p. 849 - 860 Title/Abstract Full Text Show Details

246 - 248 °C

Beck; Bosin

Biomedical Mass Spectrometry, 1979 , vol. 6, p. 19,20 Full Text Show Details

Spectra Mass Spectrometry (3) Description (Mass Spectrometry)

Reference

spectrum electron impact (EI)

Gynther, Jukka; Peura, Pekka; Salmi, Seija

Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1985 , vol. 39, # 10 p. 849 - 860 Title/Abstract Full Text Show Details

spectrum chemical ionization (CI)

Gynther, Jukka; Peura, Pekka; Salmi, Seija

Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1985 , vol. 39, # 10 p. 849 - 860 Title/Abstract Full Text Show Details

Shaw; Wright; Milne

Biomedical mass spectrometry, 1977 , vol. 4, # 6 p. 348 - 353 Title/Abstract Full Text View citing articles Show Details

Chemical Name: 5-methoxytryptamine hydrochloride

Reaxys Registry Number: 3717598

CAS Registry Number: 66-83-1 Type of Substance: heterocyclic Molecular Formula: C11H14N2O*ClH Linear Structure Formula: C11H14N2O*ClH Molecular Weight: 226.706

InChI Key: TXVAYRSEKRMEIF-UHFFFAOYSA-N

Synthesize | Hide Details Find similar Chemical Names and Synonyms 5-methoxytryptamine hydrochloride, 2-(5-methoxy-1H-indol-3-yl)ethylamine hydrochloride, 5-Methoxytryptamine hydrochloride, 5Methoxytryptamine HCl, 5-methoxytryptamine hydrochloric acid, 3-methoxytryptamine hydrochloride, o-methylserotonin hydrochloride Identification Substance Label (14) Label

Reference

Megyesi, Rita; Forró, Enikő; Fülöp, Ferenc

ChemistryOpen, 2016 , vol. 5, # 3 p. 254 - 260 Title/Abstract Full Text View citing articles Show Details

2 prep out of 137 reactions.

Identification Physical Data (4) Spectra (4) Bioactivity (45)

114

Chen, Jing; Tao, Ling-Xue; Xiao, Wei; Ji, Sha-Sha; Wang, Jian-Rong; Li, Xu-Wen; Zhang, Hai-Yan; Guo, Yue-Wei

Bioorganic and Medicinal Chemistry Letters, 2016 , vol. 26, # 15 p. 3765 - 3769 Title/Abstract Full Text View citing articles Show Details

5-MT

Odagaki; Fuxe

Journal of Pharmacology and Experimental Therapeutics, 1995 , vol. 274, # 1 p. 337 - 344 Title/Abstract Full Text View citing articles Show Details

Davison, Emma K.; Sperry, Jonathan

Organic and Biomolecular Chemistry, 2015 , vol. 13, # 29 p. 7911 - 7914 Title/Abstract Full Text View citing articles Show Details

A43

Vendrell-Navarro, Glòria; Rúa, Federico; Bujons, Jordi; Brockmeyer, Andreas; Janning, Petra; Ziegler, Slava; Messeguer, Angel; Waldmann, Herbert

ChemBioChem, 2015 , vol. 16, # 11 p. 1580 - 1587 Title/Abstract Full Text View citing articles Show Details

Liew, Lydia P.P.; Fleming, Jessica M.; Longeon, Arlette; Mouray, Elisabeth; Florent, Isabelle; Bourguet-Kondracki, Marie-Lise; Copp, Brent R.

Tetrahedron, 2014 , vol. 70, # 33 p. 4910 - 4920 Title/Abstract Full Text View citing articles Show Details

KD30

BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; OZPOLAT, Bulent; LOPEZ-BERESTEIN, Gabriel; DALBY, Kevin N.; JOSE, Jiney

Patent: WO2013/63492 A1, 2013 ; Title/Abstract Full Text Show Details

Schott, Yvonne; Decker, Michael; Rommelspacher, Hans; Lehmann, Jochen

Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 22 p. 5840 - 5843 Title/Abstract Full Text View citing articles Show Details

5-MeOT

Berner Hansen

Pharmacology and Toxicology, 1995 , vol. 76, # 2 p. 136 - 140 Title/Abstract Full Text View citing articles Show Details

Steward; Ge Jian; Stowe; Brown; Bruton; Stokes; Barnes

British Journal of Pharmacology, 1996 , vol. 117, # 1 p. 55 - 62 Title/Abstract Full Text View citing articles Show Details

Chesnoy-Marchais; Barthe

British Journal of Pharmacology, 1996 , vol. 117, # 1 p. 133 - 141 Title/Abstract Full Text View citing articles Show Details

Briejer, Michel R.; Akkermans, Louis M. A.; Lefebvre, Romain A.; Schuurkes, Jan A. J.

European Journal of Pharmacology, 1995 , vol. 279, # 2-3 p. 123 - 134 Title/Abstract Full Text View citing articles Show Details

Messori; Rizzi; Candura; Lucchelli; Balestra; Tonini

British Journal of Pharmacology, 1995 , vol. 115, # 4 p. 677 - 683 Title/Abstract Full Text View citing articles Show Details

Molderings; Froelich; Likungu; Goethert

Naunyn-Schmiedeberg's Archives of Pharmacology, 1996 , vol. 353, # 3 p. 272 - 280 Title/Abstract Full Text View citing articles Show Details

Kitazawa, Takio; Kubo, Osamu; Satoh, Masami; Taneike, Tetsuro

British Journal of Pharmacology, 1998 , vol. 123, # 2 p. 173 - 182 Title/Abstract Full Text View citing articles Show Details

Bach; Bach, Trond; Syversveen; Syversveen, Trygve; Kvingedal; Kvingedal, Ane Marit; Krobert; Krobert, Kurt Allen; Brattelid; Brattelid, Trond; Kaumann; Kaumann, Alberto Julio; Levy; Levy, Finn Olav

Naunyn-Schmiedeberg's Archives of Pharmacology, 2001 , vol. 363, # 2 p. 146 - 160 Title/Abstract Full Text View citing articles Show Details

Krobert, Kurt A.; Bach, Trond; Syversveen, Trygve; Kvingedal, Ane Marit; Levy, Finn Olav

Naunyn-Schmiedeberg's Archives of Pharmacology, 2001 , vol. 363, # 6 p. 620 - 632 Title/Abstract Full Text View citing articles Show Details

Yamada, Jun; Sugimoto, Yumi; Yoshikawa, Tomoko; Horisaka, Kazuyoshi

European Journal of Pharmacology, 1997 , vol. 323, # 2-3 p. 235 - 240 Title/Abstract Full Text View citing articles Show Details

May, Jesse A.; McLaughlin, Marsha A.; Sharif, Najam A.; Hellberg, Mark R.; Dean, Thomas R.

Journal of Pharmacology and Experimental Therapeutics, 2003 , vol. 306, # 1 p. 301 - 309 Title/Abstract Full Text View citing articles Show Details

Fokas, Demosthenes; Patterson, Jean E.; Slobodkin, Gregory; Baldino, Carmen M.

Tetrahedron Letters, 2003 , vol. 44, # 27 p. 5137 - 5140 Title/Abstract Full Text View citing articles Show Details

1, R=CH3O, R1=R2=H

Novak; Hanania; Kovacs; Kolonits; Szantay

Synthesis, 2001 , # 1 p. 108 - 118 Title/Abstract Full Text View citing articles Show Details

8*HCl

Sapi, Janos; Patigny, Dominique; Laronze, Jean-Yves

Heterocycles, 1999 , vol. 51, # 2 p. 361 - 364 Title/Abstract Full Text View citing articles Show Details

Glennon, Richard A.; Bondarev, Mikhail; Roth, Bryan

Medicinal Chemistry Research, 1999 , vol. 9, # 2 p. 108 - 117 Title/Abstract Full Text View citing articles Show Details

Shen, Shuren; Bremont, Beatrice; Serraz, Isabelle; Andrieux, Jean; Poncet, Annie; Mathe-Allainmat, Monique; Chanut, Evelyne; Trouvin, Jean-Hugues; Langlois, Michel

European Journal of Pharmacology, 1996 , vol. 307, # 2 p. 133 - 140 Title/Abstract Full Text View citing articles Show Details

Table 1, 5-MeOT

Buhlen; Fink; Boing; Gothert

Naunyn-Schmiedeberg's Archives of Pharmacology, 1996 , vol. 353, # 3 p. 281 - 289 Title/Abstract Full Text View citing articles Show Details

Patent-Specific Data (2) Related Markush Structure (RN)

Location in Patent

Reference

Claim

Wurtman, Richard J.; Lee, Robert K. K.

Patent: US2002/173511 A1, 2002 ; Title/Abstract Full Text Show Details

19816211

Les Laboratoires Servier

Patent: US6350757 B1, 2002 ;

Title/Abstract Full Text Show Details

Physical Data Melting Point (4) Melting Point

Solvent (Melting Point)

Comment (Melting Point)

Reference

120 °C

diethyl ether

Guengoer, Timur; Malabre, Patrice; Teulon, Jean-Marie; Camborde, Francoise; Meignen, Joelle; et al.

Journal of Medicinal Chemistry, 1994 , vol. 37, # 25 p. 4307 - 4316 Title/Abstract Full Text Show Details

121 °C

benzene

Alapishvili, M. G.; Popova, G. V.; Vorontsov, E. D.; Kireev, V. V.; Suvorov, N. N.

J. Gen. Chem. USSR (Engl. Transl.), 1983 , vol. 53, # 5 p. 1040 - 1044,919 - 923 Title/Abstract Full Text Show Details

234 - 235 °C

Quadbeck; Roehm

Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1954 , vol. 297, p. 229,233 Full Text Show Details

245 °C

ethanol

Decomp.

Hoshino; Kobayashi

Justus Liebigs Annalen der Chemie, 1935 , vol. 516, p. 81,88 Justus Liebigs Annalen der Chemie, 1935 , vol. 520, p. 11,19 Full Text Show Details

Spectra NMR Spectroscopy (2) Description (NMR Spectroscopy)

Nucleus (NMR Spectroscopy)

Solvents (NMR Spectroscopy)

Chemical shifts

dimethylsulfoxided6

Frequency (NMR Spectroscopy) 400 MHz

Original Text (NMR Spectroscopy)

Location

Reference

Paragraph 0550

BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; OZPOLAT, Bulent; LOPEZ-BERESTEIN, Gabriel; DALBY, Kevin N.; JOSE, Jiney

Patent: WO2013/63492 A1, 2013 ;

NMR (400 MHz, DMSO-i?) ? 10.60 (s, 1H), 8.01 (br, 2H), 7.27 - 7.1 1 (m, 1H), 7.05 (d, J= 2.0 Hz, 1H), 6.98 (d, J= 2.0 Hz, 1H), 6.75 - 6.62 (dd, J= 6.3 Hz, 2.0 Hz, 1H), 3.73 (s, 3H), 2.86 - 2.61 (m, 4H).

Title/Abstract Full Text Show Details

Chemical shifts

13C

dimethylsulfoxided6

101 MHz

13C

NMR (101 MHz, DMSO-i?) ? 153.29, 131.82, 128.06, 123.69, 1 12.81, 112.36, 11 1.37, 100.57, 55.76, 43.13, 30.08.

Paragraph 0550

BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; OZPOLAT, Bulent; LOPEZ-BERESTEIN, Gabriel; DALBY, Kevin N.; JOSE, Jiney

Patent: WO2013/63492 A1, 2013 ; Title/Abstract Full Text Show Details

Mass Spectrometry (2) Description (Mass Spectrometry)

Location

Reference

electrospray ionisation (ESI) liquid chromatography mass spectrometry (LCMS) spectrum

Paragraph 0550

BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; OZPOLAT, Bulent; LOPEZ-BERESTEIN, Gabriel; DALBY, Kevin N.; JOSE, Jiney

Patent: WO2013/63492 A1, 2013 ;

Title/Abstract Full Text Show Details

high resolution mass spectrometry (HRMS) spectrum

Paragraph 0550

BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; OZPOLAT, Bulent; LOPEZ-BERESTEIN, Gabriel; DALBY, Kevin N.; JOSE, Jiney

Patent: WO2013/63492 A1, 2013 ; Title/Abstract Full Text Show Details

Bioactivity Pharmacological Data (45) 1 of 45

Comment (Pharmacological Data)

Bioactivities present

Reference

E. R. Squibb and Sons, Inc.

Patent: US4104467 A1, 1978 ; Title/Abstract Full Text Show Details

Novo Nordisk A/S

Patent: US5126363 A1, 1992 ; Title/Abstract Full Text Show Details

Eli Lilly and Company

Patent: US5688807 A1, 1997 ; Title/Abstract Full Text Show Details

THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

Patent: WO2002/48150 A2, 2002 ; Title/Abstract Full Text Show Details

FAUST PHARMACEUTICALS

Patent: WO2004/85392 A1, 2004 ; Title/Abstract Full Text Show Details

WARNER-LAMBERT COMPANY LLC

Patent: WO2005/100305 A1, 2005 ; Title/Abstract Full Text Show Details

Hoshino; Kobayashi

Justus Liebigs Annalen der Chemie, 1935 , vol. 516, p. 81,88 Justus Liebigs Annalen der Chemie, 1935 , vol. 520, p. 11,19 Full Text Show Details

Logemann et al.

Chemische Berichte, 1955 , vol. 88, p. 1952,1954 Full Text Show Details

Quadbeck; Roehm

Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1954 , vol. 297, p. 229,233 Full Text Show Details

Misztal, Stanislaw; Bielecka, Zofia; Mokrosz, Jerzy L.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 8 p. 1871 - 1874 Title/Abstract Full Text View citing articles Show Details

Elswood; Bunce

Journal of Pharmacy and Pharmacology, 1992 , vol. 44, # 3 p. 264 - 266 Title/Abstract Full Text View citing articles Show Details

Biswas, Kshetra M.; Jackson, Anthony H.; Kobaisy, Mozaina M.; Shannon, Patrick V. R.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 4 p. 461 - 468 Title/Abstract Full Text View citing articles Show Details

Burov, Yu. V.; Zagorevskii, V. A.; Zhukov, V. N.; Novikova, N. N.; Silenko, I. D.

Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 8 p. 559 - 563 Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 8 p. 936 - 940 Title/Abstract Full Text View citing articles Show Details

Gynther, Jukka; Peura, Pekka; Salmi, Seija

Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1985 , vol. 39, # 10 p. 849 - 860 Title/Abstract Full Text Show Details

Copinga, Swier; Tepper, Pieter G.; Grol, Cor J.; Horn, Alan S.; Dubocovich, Margarita L.

Journal of Medicinal Chemistry, 1993 , vol. 36, # 20 p. 2891 - 2898 Title/Abstract Full Text View citing articles Show Details

Alapishvili, M. G.; Popova, G. V.; Vorontsov, E. D.; Kireev, V. V.; Suvorov, N. N.

J. Gen. Chem. USSR (Engl. Transl.), 1983 , vol. 53, # 5 p. 1040 - 1044,919 - 923 Title/Abstract Full Text Show Details

Mokrosz, Maria J.; Kowalski, Piotr; Bojarski, Andrzej J.; Mokrosz, Jerzy L.

Heterocycles, 1994 , vol. 37, # 1 p. 265 - 274 Title/Abstract Full Text View citing articles Show Details

Depreux; Lesieur; Mansour; Morgan; Howell; Renard; Caignard; Pfeiffer; Delagrange; Guardiola; Yous; Demarque; Adam; Andrieux

Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3231 - 3239 Title/Abstract Full Text View citing articles Show Details

Guengoer, Timur; Malabre, Patrice; Teulon, Jean-Marie; Camborde, Francoise; Meignen, Joelle; et al.

Journal of Medicinal Chemistry, 1994 , vol. 37, # 25 p. 4307 - 4316 Title/Abstract Full Text Show Details

Franks; Hardcastle; Sanger

Journal of Pharmacy and Pharmacology, 1995 , vol. 47, # 3 p. 213 - 218 Title/Abstract Full Text View citing articles Show Details

2 of 45

3 of 45

Comment (Pharmacological Data)

Bioactivities present

Reference

Kawashima; Horiguchi; Taguchi; Tuyuki; Karasawa; Araki; Hatayama

Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 5 p. 783 - 787 Title/Abstract Full Text View citing articles Show Details

Audia, James E.; Evrard, Deborah A.; Murdoch, Gwyn R.; Droste, James J.; Nissen, Jeffrey S.; Schenck, Kathy W.; Fludzinski, Pawel; Lucaites, Virginia L.; Nelson, David L.; Cohen, Marlene L.

Journal of Medicinal Chemistry, 1996 , vol. 39, # 14 p. 2773 - 2780 Title/Abstract Full Text View citing articles Show Details

Cantrell, Amanda S.; Engelhardt, Per; Hoegberg, Marita; Jaskunas, S. Richard; Johansson, Nils Gunnar; Jordan, Christopher L.; Kangasmetsae, Jussi; Kinnick, Michael D.; Lind, Peter; Morin Jr., John M.; Muesing; Noreen, Rolf; Oeberg, Bo; Pranc, Paul; Sahlberg, Christer; Ternansky, Robert J.; Vasileff, Robert T.; Vrang, Lotta; West, Sarah J.; Zhang, Hong

Journal of Medicinal Chemistry, 1996 , vol. 39, # 21 p. 4261 - 4274 Title/Abstract Full Text View citing articles Show Details

Li, Jianxiong; Chen, Genhui; Webster, John M.

Bioorg. Med. Chem. Lett., 1997 , vol. 7, # 10 p. 1349 - 1352 Title/Abstract Full Text Show Details

Bezuglov; Manevich; Archakov; Bobrov; Kuklev; Petrukhina; Makarov; Buznikov

Russian Journal of Bioorganic Chemistry, 1997 , vol. 23, # 3 p. 190 - 198 Title/Abstract Full Text View citing articles Show Details

Yamano, Mayumi; Kamato, Takeshi; Miyata, Keiji

Arzneimittel-Forschung/Drug Research, 1997 , vol. 47, # 11 p. 1242 - 1246 Title/Abstract Full Text View citing articles Show Details

Leclerc, Veronique; Fourmaintraux, Eric; Depreux, Patrick; Lesieur, Daniel; Morgan, Peter; Howell, H. Edward; Renard, Pierre; Caignard, Daniel-Henri; Pfeiffer, Bruno; Delagrange, Philippe; Guardiola-Lemaitre, Beatrice; Andrieux, Jean

Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 10 p. 1875 - 1887 Title/Abstract Full Text View citing articles Show Details

Berner Hansen

Pharmacology and Toxicology, 1995 , vol. 76, # 2 p. 136 - 140 Title/Abstract Full Text View citing articles Show Details

Steward; Ge Jian; Stowe; Brown; Bruton; Stokes; Barnes

British Journal of Pharmacology, 1996 , vol. 117, # 1 p. 55 - 62 Title/Abstract Full Text View citing articles Show Details

Chesnoy-Marchais; Barthe

British Journal of Pharmacology, 1996 , vol. 117, # 1 p. 133 - 141 Title/Abstract Full Text View citing articles Show Details

Briejer, Michel R.; Akkermans, Louis M. A.; Lefebvre, Romain A.; Schuurkes, Jan A. J.

European Journal of Pharmacology, 1995 , vol. 279, # 2-3 p. 123 - 134 Title/Abstract Full Text View citing articles Show Details

Sapi, Janos; Patigny, Dominique; Laronze, Jean-Yves

Heterocycles, 1999 , vol. 51, # 2 p. 361 - 364 Title/Abstract Full Text View citing articles Show Details

Messori; Rizzi; Candura; Lucchelli; Balestra; Tonini

British Journal of Pharmacology, 1995 , vol. 115, # 4 p. 677 - 683 Title/Abstract Full Text View citing articles Show Details

Chesnoy-Marchais

British Journal of Pharmacology, 1996 , vol. 118, # 8 p. 2115 - 2125 Title/Abstract Full Text View citing articles Show Details

Odagaki; Fuxe

Journal of Pharmacology and Experimental Therapeutics, 1995 , vol. 274, # 1 p. 337 - 344 Title/Abstract Full Text View citing articles Show Details

Novak; Hanania; Kovacs; Kolonits; Szantay

Synthesis, 2001 , # 1 p. 108 - 118 Title/Abstract Full Text View citing articles Show Details

Shen, Shuren; Bremont, Beatrice; Serraz, Isabelle; Andrieux, Jean; Poncet, Annie; Mathe-Allainmat, Monique; Chanut, Evelyne; Trouvin, JeanHugues; Langlois, Michel

European Journal of Pharmacology, 1996 , vol. 307, # 2 p. 133 - 140 Title/Abstract Full Text View citing articles Show Details

Briejer; Schuurkes

European journal of pharmacology, 1996 , vol. 308, # 2 p. 173 - 180 Title/Abstract Full Text View citing articles Show Details