2-(Methylamino)-1-phenylpropan-1-one [Methcathinone]

Page 1

Reaxys

PubChem

eMolecules

Reactions (25)

Yield

Substances (7)

Citations (29)

Conditions

References

1

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With chromium(VI) oxide

Rx-ID: 333850 Find similar reactions

Parke, Davis and Co.

Patent: US2802865 , 1954 ; Full Text Show Details

Stage #1: With sodium dichromate; sulfuric acid in water

T=15 - 20°C; 12.3333 h; Stage #2: With sodium hydroxide in water; toluene

T=20°C; pH=10.5; Further stages;

Hitesh Kumar, Borkatte N.; Murugesan, Velayudham; Prakasam, Tangirala; Srinivasan, Pathangi S.; Ramana, Devalla V.

Tetrahedron Asymmetry, 2009 , vol. 20, # 24 p. 2773 - 2779 Title/Abstract Full Text View citing articles Show Details

With potassium permanganate

Mohr, Stefan; Taschwer, Magdalena; Schmid, Martin G.

Chirality, 2012 , vol. 24, # 6 p. 486 - 492 Title/Abstract Full Text View citing articles Show Details

With (R)-epinephrine dehydrogenase; Reduced nicotinamide-adenine

He, Shengbin; Wang, Zhenshou; Zou, Yang; Chen, Shaofang; Xu, Xiaoping


dinucleotide in aq. phosphate buffer

T=45°C; pH=6; Enzymatic reaction;

Process Biochemistry, 2014 , vol. 49, # 7 p. 1107 - 1112 Title/Abstract Full Text View citing articles Show Details

2

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Rx-ID: 437426 Find similar reactions

Takamatsu

Yakugaku Zasshi, 1956 , vol. 76, p. 1227 Chem.Abstr., 1957 , p. 4304 Full Text Show Details

Parke, Davis and Co.

Patent: US2802865 , 1954 ; Full Text Show Details

3

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Rx-ID: 437427 Find similar reactions

Takamatsu

Yakugaku Zasshi, 1956 , vol. 76, p. 1227 Chem.Abstr., 1957 , p. 4304 Full Text Show Details

4

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Rx-ID: 438154 Find similar reactions

Merck

Patent: DE495534 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 16, p. 2467


Full Text Show Details

5

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With hydrogenchloride; palladium on activated charcoal

Hydrogenation;

Rx-ID: 441936 Find similar reactions

Takamatsu

Yakugaku Zasshi, 1956 , vol. 76, p. 1227 Chem.Abstr., 1957 , p. 4304 Full Text Show Details

6

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With hydrogenchloride

T=100 - 110°C;

Rx-ID: 505904 Find similar reactions

I.G. Farbenind. Patent: DE468305 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 16, p. 2835 Full Text Show Details

7

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Rx-ID: 667336 Find similar reactions

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Fourneau; Kanao

Bulletin de la Societe Chimique de France, 1924 , vol. <4> 35, p. 620 Full Text Show Details

Hyde; Browning; Adams

Journal of the American Chemical Society, 1928 , vol. 50, p. 2290 Full Text Show Details


Eberhard

Archiv der Pharmazie (Weinheim, Germany), 1920 , vol. 258, p. 104 Full Text Show Details

Merck,E.

Patent: DE472466 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 16, p. 2834 Full Text Show Details

Kurashima, Naoki; Makino, Yukiko; Sekita, Setsuko; Urano, Yasuteru; Nagano, Tetsuo

Analytical Chemistry, 2004 , vol. 76, # 14 p. 4233 - 4236 Title/Abstract Full Text View citing articles Show Details

With benzene

T=0°C;

Eberhard

Archiv der Pharmazie (Weinheim, Germany), 1915 , vol. 253, p. 89 Full Text Show Details

Schmidt,E.

Chem. Zentralbl., 1911 , vol. 82, # II p. 33 Full Text Show Details

in ethanol

T=0°C; 1.5 h;

Findlay; Warren; Hill; Welch

Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 6 p. 624 - 631 Title/Abstract Full Text View citing articles Show Details

8

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Rx-ID: 724513 Find similar reactions

With water; bromine; benzene

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Kamlet

Patent: US2155194 , 1938 ; Full Text Show Details

With sodium hydroxide; ethanol; bromine

Kamlet

Patent: US2155194 , 1938 ; Full Text Show Details

Stage #1: 1-phenyl-propan-1-one With bromine

Stage #2: methylamine

9

Salouros, Helen; Sutton, Gordon J.; Howes, Joanna; Hibbert, D. Brynn; Collins, Michael

Analytical Chemistry, 2013 , vol. 85, # 19 p. 9400 - 9408 Title/Abstract Full Text View citing articles Show Details


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Rx-ID: 772698 Find similar reactions

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With water; palladium

Hydrogenation;

Skita; Keil; Baesler

Chemische Berichte, 1933 , vol. 66, p. 865 Full Text Show Details

Knoll A.G.

Patent: DE634002 , 1930 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 23, p. 481 Full Text Show Details

With water; platinum

Hydrogenation;

Skita; Keil; Baesler

Chemische Berichte, 1933 , vol. 66, p. 865 Full Text Show Details

Knoll A.G.

Patent: DE634002 , 1930 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 23, p. 481 Full Text Show Details

10

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With manganese(IV) oxide; oxonium

Yield given. Multistep reaction;

Rx-ID: 2177585 Find similar reactions

Tytgat, D.; Gelbcke, M.

Bulletin des Societes Chimiques Belges, 1989 , vol. 98, # 4 p. 243 - 256 Title/Abstract Full Text Show Details

11

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With trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in dimethyl sulfoxide

2.5 h; Ambient temperature;

Rx-ID: 4459789 Find similar reactions

Frigerio, Marco; Santagostino, Marco; Sputore, Simona; Palmisano, Giovanni

Journal of Organic Chemistry, 1995 , vol. 60, # 22 p. 7272 - 7276 Title/Abstract Full Text View citing articles Show Details


12

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Rx-ID: 7788614 Find similar reactions

Bekett et al.

Journal of Pharmacy and Pharmacology, 1978 , vol. 30, p. 14,17 Full Text Show Details

Ephedrin, Ag2CO3;

1) Propiophenon, Br2, Bzl.; 2) Methylamin-hydrochlorid, wss. NaOH;

Fel'dman et al.

J. Appl. Chem. USSR (Engl. Transl.), 1962 , vol. 35, p. 1364,1309 Chem.Abstr., 1962 , vol. 57, # 11064 Full Text Show Details

13

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Rx-ID: 7993925 Find similar reactions

Merck,E.

Patent: DE495534 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 16, p. 2467 Full Text Show Details

14

Synthesize Find similar With methoxybenzene; trifluoroacetic acid in dichloromethane

0.75 h;

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Rx-ID: 9993677 Find similar reactions

Fraser, David S.; Park, Sheldon B.; Chong, J. Michael

Canadian Journal of Chemistry, 2004 , vol. 82, # 2 p. 87 - 101 Title/Abstract Full Text View citing articles Show Details


15

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Multi-step reaction with 2 steps 1: 92 percent / N-methylmorpholine-N-oxide; 4 Angstroem molecular sieves; tetrapropylammonium perruthenate / CH2Cl2 / 1 h 2: anisole; TFA / CH2Cl2 / 0.75 h View Scheme

Rx-ID: 12805480 Find similar reactions

Fraser, David S.; Park, Sheldon B.; Chong, J. Michael

Canadian Journal of Chemistry, 2004 , vol. 82, # 2 p. 87 - 101 Title/Abstract Full Text View citing articles Show Details

16

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Multi-step reaction with 3 steps 1.1: BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C 1.2: 91 percent / tetrahydrofuran; hexane / 0.25 h / -78 °C 2.1: 92 percent / N-methylmorpholine-N-oxide; 4 Angstroem molecular sieves; tetrapropylammonium perruthenate / CH2Cl2 / 1 h 3.1: anisole; TFA / CH2Cl2 / 0.75 h View Scheme

Rx-ID: 12832364 Find similar reactions

Fraser, David S.; Park, Sheldon B.; Chong, J. Michael

Canadian Journal of Chemistry, 2004 , vol. 82, # 2 p. 87 - 101 Title/Abstract Full Text View citing articles Show Details

17

Synthesize Find similar Multi-step reaction with 2 steps 1: Br2

View Scheme

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Rx-ID: 12878677 Find similar reactions

Kurashima, Naoki; Makino, Yukiko; Sekita, Setsuko; Urano, Yasuteru; Nagano, Tetsuo

Analytical Chemistry, 2004 , vol. 76, # 14 p. 4233 - 4236 Title/Abstract Full Text View citing articles Show Details


18

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Multi-step reaction with 2 steps 1: Br2 / CH2Cl2 / 1 h / Heating 2: ethanol / 1.5 h / 0 °C View Scheme

Rx-ID: 18577003 Find similar reactions

Findlay; Warren; Hill; Welch

Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 6 p. 624 - 631 Title/Abstract Full Text View citing articles Show Details

19

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Multi-step reaction with 2 steps 1: palladium/charcoal; aqueous methanol. HCl / Hydrogenation View Scheme

Rx-ID: 22222165 Find similar reactions

Takamatsu

Yakugaku Zasshi, 1956 , vol. 76, p. 1227 Chem.Abstr., 1957 , p. 4304 Full Text Show Details

20

Synthesize Find similar Multi-step reaction with 2 steps 1: palladium/charcoal; aqueous methanol. HCl / Hydrogenation View Scheme

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Rx-ID: 22222166 Find similar reactions

Takamatsu

Yakugaku Zasshi, 1956 , vol. 76, p. 1227 Chem.Abstr., 1957 , p. 4304 Full Text Show Details


21

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Rx-ID: 29130431 Find similar reactions

Stage #1: With sodium dichromate; sulfuric acid in water

T=15 - 20°C; 12.3333 h; Stage #2: With sodium hydroxide in water; toluene

T=20°C; pH=10.5; Further stages;

Hitesh Kumar, Borkatte N.; Murugesan, Velayudham; Prakasam, Tangirala; Srinivasan, Pathangi S.; Ramana, Devalla V.

Tetrahedron Asymmetry, 2009 , vol. 20, # 24 p. 2773 - 2779 Title/Abstract Full Text View citing articles Show Details

With potassium permanganate

Mohr, Stefan; Taschwer, Magdalena; Schmid, Martin G.

Chirality, 2012 , vol. 24, # 6 p. 486 - 492 Title/Abstract Full Text View citing articles Show Details

22

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With potassium permanganate; acetic acid

T=20 - 60°C; 0.5 h;

Rx-ID: 33584347 Find similar reactions

Smoluch, Marek; Reszke, Edward; Ramsza, Andrzej; Labuz, Krzysztof; Silberring, Jerzy

Rapid Communications in Mass Spectrometry, 2012 , vol. 26, # 13 p. 1577 - 1580 Title/Abstract Full Text View citing articles Show Details

23

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Rx-ID: 7790490 Find similar reactions

/BRN= 941041/, 1) Br2, CS2, 2) CH3NH2, /BRN= 969212/;

Nagase et al.

Yakugaku Zasshi, 1961 , vol. 81, p. 1479 Chem.Abstr., 1962 , vol. 56, # 8608 Full Text Show Details


24

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Rx-ID: 5056819 Find similar reactions

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With triethylamine in methanol; toluene

T=100°C; Methylation; 0.25 h;

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Cozzi, Nicholas V.; Ruoho, Arnold E.

Journal of Labelled Compounds and Radiopharmaceuticals, 1998 , vol. 41, # 10 p. 927 - 933 Title/Abstract Full Text View citing articles Show Details

25

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Rx-ID: 34581570 Find similar reactions

Stage #1: in tetrahydrofuran

Stage #2: With hydrogenchloride in diethyl ether; water

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Power, John D.; McDermott, Sean D.; Talbot, Brian; O'Brien, John E.; Kavanagh, Pierce

Rapid Communications in Mass Spectrometry, 2012 , vol. 26, # 22 p. 2601 - 2611 Title/Abstract Full Text View citing articles Show Details


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