2-Methyl-3-(o-tolyl)quinazolin-4(3H)-one (Methaqualone) by Asch

Reaxys

PubChem

eMolecules

Reactions (98)

Substances (6)

Structure

Citations (226)

Structure/Compound Data Chemical Name: methaqualone Reaxys Registry Number: 211874

CAS Registry Number: 72-44-6 Type of Substance: heterocyclic Molecular Formula: C16H14N2O Linear Structure Formula: C16H14N2O Molecular Weight: 250.3

InChI Key: JEYCTXHKTXCGPB-UHFFFAOYSA-N

N° of preparations All Preps | All Reactions 26 prep out of 92 reactions.

Synthesize | Hide Details Find similar Chemical Names and Synonyms methaqualone, 2-methyl-3-o-tolyl-4(3H)-quinazolinone, Methaqualone, Aqual, 2-methyl-3-(ortho-tolyl)-4(3H)-quinazolinone, 2-methyl-3-(otolyl)quinazolin-4(3H)-one, 2-methyl-3-o-tolylquinazolin-4(3H)-one Identification Substance Label (8) Label

Reference

3eA

Shen, Guanshuo; Zhou, Haifeng; Du, Peng; Liu, Sensheng; Zou, Kun; Uozumi, Yasuhiro

RSC Advances, 2015 , vol. 5, # 104 p. 85646 - 85651 Title/Abstract Full Text View citing articles Show Details

Shen, Guanshuo; Zhou, Haifeng; Sui, Yuebo; Liu, Qixing; Zou, Kun

Tetrahedron Letters, 2016 , vol. 57, # 5 p. 587 - 590 Title/Abstract Full Text View citing articles Show Details

12a

Ghosh, Suman Kr; Nagarajan, Rajagopal

RSC Advances, 2016 , vol. 6, # 33 p. 27378 - 27387

Available Data

N° of ref.

Identification Physical Data (59) Spectra (41) Bioactivity (60) Other Data (4)

212

Title/Abstract Full Text View citing articles Show Details

Xu, Wei; Zhu, Xiao-Rui; Qian, Peng-Cheng; Zhang, Xing-Guo; Deng, Chen-Liang

Synlett, 2016 , vol. 27, # 20 art. no. ST-2016-W0432-L, p. 2851 - 2857 Title/Abstract Full Text Show Details

Kumar, Dinesh; Jadhavar, Pradeep S.; Nautiyal, Manesh; Sharma, Himanshu; Meena, Prahlad K.; Adane, Legesse; Pancholia, Sahaj; Chakraborti, Asit K.

RSC Advances, 2015 , vol. 5, # 39 p. 30819 - 30825 Title/Abstract Full Text View citing articles Show Details

Wang, Long; Wang, Ying; Chen, Min; Ding, Ming-Wu

Advanced Synthesis and Catalysis, 2014 , vol. 356, # 5 p. 1098 - 1104 Title/Abstract Full Text View citing articles Show Details

Vanparia, Satish F.; Patel, Tarosh S.; Dixit, Ritu B.; Dixit, Bharat C.

Medicinal Chemistry Research, 2013 , vol. 22, # 11 p. 5184 - 5196 Title/Abstract Full Text View citing articles Show Details

tab2, product, entry8

Salehi, Peyman; Dabiri, Minoo; Zolfigol, Mohammad Ali; Baghbanzadeh, Mostafa

Tetrahedron Letters, 2005 , vol. 46, # 41 p. 7051 - 7053 Title/Abstract Full Text View citing articles Show Details

Jeong, Jae Uk; Chen, Xiaohong; Rahman, Attiq; Yamashita, Dennis S.; Luengo, Juan I.

Organic Letters, 2004 , vol. 6, # 6 p. 1013 - 1016 Title/Abstract Full Text View citing articles Show Details

Related Structure (1) Related Structure

Reference

Zusammenfassende Darstellung.

Patel et al. bzw. Janicki; Gilpin

in K. Florey, Analytical Profiles of Drug Substances, Bd. 4 <New York 1975> S. 246 bzw. Bd. 7 <New York 1978> S. 171 Full Text Show Details

Derivative (6) Comment (Derivative)

Reference

Hydrochlorid: F = 235-237grad

Manhas; Amin; Rao

Synthesis, 1977 , vol. No. 5, p. 309 - 310 Title/Abstract Full Text View citing articles Show Details

Pikrat: F = 161-162grad

Schnellbach; Houta

Pharmaceutica Acta Helvetiae, 1972 , vol. 47, p. 75,76,78-82 Full Text Show Details

Hydrochlorid; F: 250 - 256grad

Nord. Droge and Kem. AIS

Patent: NL295501 , 1965 ; Chem.Abstr., 1965 , vol. 63, # 18113g Full Text Show Details

Chlorhydrat: B.: Acetylanthranilsaeure, 1) o-Toluidin, PCl3, 2) HCl; F. 190-193grad

Zotta et al.

Farmacia (Bucharest, Romania), 1964 , vol. 12, p. 599,603 Full Text Show Details

Hydrochlorid: 238-240grad

Andrisano; Chiesi

Ateneo Parmense, 1961 , vol. 32, p. 671 Chem.Abstr., 1963 , vol. 58, # 3428c Full Text Show Details

Hydrochlorid (C16H14N2O*HCl): F. 252-254grad; Analyse

Klosa

Journal fuer Praktische Chemie (Leipzig), 1961 , vol. 14, p. 84 Full Text Show Details

Physical Data Melting Point (25) Melting Point 119 121 °C

Solvent (Melting Point)

Location

Reference

supporting information

Shen, Guanshuo; Zhou, Haifeng; Sui, Yuebo; Liu, Qixing; Zou, Kun

Tetrahedron Letters, 2016 , vol. 57, # 5 p. 587 - 590

Title/Abstract Full Text View citing articles Show Details

Xu, Wei; Zhu, Xiao-Rui; Qian, Peng-Cheng; Zhang, Xing-Guo; Deng, Chen-Liang

Synlett, 2016 , vol. 27, # 20 art. no. ST-2016-W0432-L, p. 2851 - 2857 Title/Abstract Full Text Show Details

112 °C

Ghosh, Suman Kr; Nagarajan, Rajagopal

RSC Advances, 2016 , vol. 6, # 33 p. 27378 - 27387 Title/Abstract Full Text View citing articles Show Details

118 119 °C

ethanol

Kumar, Dinesh; Jadhavar, Pradeep S.; Nautiyal, Manesh; Sharma, Himanshu; Meena, Prahlad K.; Adane, Legesse; Pancholia, Sahaj; Chakraborti, Asit K.

RSC Advances, 2015 , vol. 5, # 39 p. 30819 - 30825 Title/Abstract Full Text View citing articles Show Details

116 118 °C

Wang, Long; Wang, Ying; Chen, Min; Ding, Ming-Wu

Advanced Synthesis and Catalysis, 2014 , vol. 356, # 5 p. 1098 - 1104 Title/Abstract Full Text View citing articles Show Details

112 114 °C

supporting information

Fang, Jie; Zhou, Jianguang

Organic and Biomolecular Chemistry, 2012 , vol. 10, # 12 p. 2389 - 2391 Title/Abstract Full Text View citing articles Show Details

114 117 °C

Schleuder; Duerrbeck; Jira

Pharmazie, 1998 , vol. 53, # 6 p. 381 - 386 Title/Abstract Full Text View citing articles Show Details

112.5 113 °C

Soliman

Synthesis, 1979 , vol. No 10, p. 803 - 804 Title/Abstract Full Text View citing articles Show Details

Soliman; Shafik; Elnenaey

Journal of Pharmaceutical Sciences, 1978 , vol. 67, # 3 p. 411 - 413 Title/Abstract Full Text View citing articles Show Details

114 116 °C

Stroh

Patent: DD65928 , 1968 ; Chem.Abstr., 1969 , vol. 71, # 124485x Full Text Show Details

Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.

Patent: AT235839 , 1962 ; Chem.Abstr., 1965 , vol. 62, # 575c Full Text Show Details

Yamamoto; Koyama; Eyanagi; Yoshida

Chemical and Pharmaceutical Bulletin, 1977 , vol. 25, # 3 p. 397 - 400 Title/Abstract Full Text View citing articles Show Details

Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.

Patent: HU150883 , 1962 ; Chem.Abstr., 1964 , vol. 60, # 6855c Full Text Show Details

113 115 °C

Klosa

Journal fuer Praktische Chemie (Leipzig), 1961 , vol. 14, p. 84 Full Text Show Details

Stefanova et al.

Pharmaceutical Chemistry Journal, 1973 , vol. 7, # 10 p. 626 Khimiko-Farmatsevticheskii Zhurnal, 1973 , vol. 7, # 10 p. 19 Full Text View citing articles Show Details

Hans Starke

Patent: DD35123 , 1962 ; Chem.Abstr., 1965 , vol. 63, # 8377d Full Text Show Details

The Sherwin-Williams Co.(USA)

Patent: FR2301524DE2556590 , 1976 ; Chem.Abstr., vol. 85, # 160115z Full Text Show Details

114 115 °C

Moehrle; Seidel

Archiv der Pharmazie (Weinheim, Germany), 1976 , vol. 309, p. 471,473,478 Full Text View citing articles Show Details

Warner Lambert Pharm. Co.

Patent: GB1114920 , 1966 ; Chem.Abstr., 1968 , vol. 69, # 59274v Full Text Show Details

113 114 °C

Orgamol

Patent: GB982207 , 1965 ; Chem.Abstr., 1965 , vol. 62, # 16268e Full Text Show Details

Nord. Droge and Kem. AIS

Patent: NL295501 , 1965 ; Chem.Abstr., 1965 , vol. 63, # 18113g

Full Text Show Details

Errede et al.

Journal of Organic Chemistry, 1976 , vol. 41, p. 1765 Full Text View citing articles Show Details

115 °C

Hisano; Ichikawa; Nakagawa; Tsuji

Chemical and Pharmaceutical Bulletin, 1975 , vol. 23, # 9 p. 1910 - 1916 Title/Abstract Full Text View citing articles Show Details

Pesson; Richer

Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1968 , vol. 266, p. 1787 Full Text Show Details

115.5 116 °C

Schnellbach; Houta

Pharmaceutica Acta Helvetiae, 1972 , vol. 47, p. 75,76,78-82 Full Text Show Details

112.2 112.9 °C

Gronowitz et al.

Acta Pharmaceutica Suecica, 1968 , vol. 5, p. 563,567,570 Full Text View citing articles Show Details

115 116 °C

Kacker; Zaheer

Journal of the Indian Chemical Society, 1951 , vol. 28, p. 344 Full Text Show Details

Petyunin; Kozhevnikov

Meditsinskaya Promyshlennost SSSR, 1966 , vol. 20, # 4 p. 13,14,15 Chem.Abstr., 1966 , vol. 65, # 7176b Full Text Show Details

113 114 °C

ethanol

Petjunin; Koshewnikow

Biol. Akt. Soedin., 1965 , p. 152,153,154,155 Full Text Show Details

112 116 °C

Brandstaetter-Kuhnert et al.

Scientia Pharmaceutica, 1963 , vol. 31, p. 140,146 Full Text Show Details

116 °C

ethanol

Akagi et al.

Chemical and Pharmaceutical Bulletin, 1963 , vol. 11, p. 58,60 Full Text Show Details

116 117 °C

Chinoin Gyog. es Veg. Termekek Gyara Rt.

Patent: HU149660 , 1960 ; Chem.Abstr., 1963 , vol. 58, # 4585d Full Text Show Details

General Anilin and Film Corp.

Patent: US3213094 , 1963 ; Chem.Abstr., 1966 , vol. 64, # 2107b Full Text Show Details

113 115 °C

aq. methanol

Klosa

Journal fuer Praktische Chemie (Leipzig), 1963 , vol. 20, p. 283 Full Text Show Details

Hide facts Melting Point

Solvent (Melting Point)

Reference

115.5 °C

BOLTZE; DELL; LEHWALD; LORENZ; RUEBERG-SCHWEER

Arzneimittel-Forschung, 1963 , vol. 13, p. 688 - 701 Title/Abstract Full Text View citing articles Show Details

120 °C

Andrisano; Chiesi

Ateneo Parmense, 1961 , vol. 32, p. 671 Chem.Abstr., 1963 , vol. 58, # 3428c Full Text Show Details

118 °C

Grammaticakis

Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1961 , vol. 252, p. 4011 Full Text Show Details

119 °C

Grammaticakis

Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1961 , vol. 252, p. 4011 Full Text Show Details

120 °C

aq. ethanol

Serventi; Marchesi

Bollettino Scientifico della Facolta di Chimica Industriale di Bologna, 1957 , vol. 15, p. 114 Full Text Show Details

Adsorption (MCS) (8) Description (Adsorption (MCS))

Partner (Adsorption (MCS))

Solvent (Adsorption (MCS))

Temperature (Adsorption (MCS))

Comment (Adsorption (MCS))

Adsorption

activated carbon ASO

aq. ethanol

25 °C

Philippson Chr.; Schmiedel

Pharmazie, 1983 , vol. 38, # 3 p. 181 - 182 Title/Abstract Full Text View citing articles Show Details

Adsorption

activated carbon R 4

aq. ethanol

25 °C

Philippson Chr.; Schmiedel

Pharmazie, 1983 , vol. 38, # 3 p. 181 - 182 Title/Abstract Full Text View citing articles Show Details

Adsorption

activated carbon walnut coal

aq. ethanol

25 °C

Philippson Chr.; Schmiedel

Pharmazie, 1983 , vol. 38, # 3 p. 181 - 182 Title/Abstract Full Text View citing articles Show Details

Adsorption

cross-linked insoluble polyvinylpyrrolidone

H2O

37 °C

Fromming; Ditter; Horn

Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 7 p. 738 - 743 Title/Abstract Full Text View citing articles Show Details

Chemisorption

cross-linked insoluble polyvinylpyrrolidone

H2O

37 °C

Fromming; Ditter; Horn

Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 7 p. 738 - 743 Title/Abstract Full Text View citing articles Show Details

Adsorption

cross-linked insoluble polyvinylpyrrolidone

H2O HCl

37 °C

Ratio of solvents: 0.01N

Fromming; Ditter; Horn

Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 7 p. 738 - 743 Title/Abstract Full Text View citing articles Show Details

Chemisorption

cross-linked insoluble polyvinylpyrrolidone

H2O HCl

37 °C

Ratio of solvents: 0.01N

Fromming; Ditter; Horn

Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 7 p. 738 - 743 Title/Abstract Full Text View citing articles Show Details

Adsorption isotherm

Sellers; Khouw; Dolman

Journal of Pharmaceutical Sciences, 1977 , vol. 66, # 11 p. 1640 - 1641 Title/Abstract Full Text View citing articles Show Details

Reference

Association (MCS) (5) Description (Association (MCS))

Partner (Association (MCS))

Solvent (Association (MCS))

Temperature (Association (MCS))

Association with compound

4-nitro-phenol

tetrachloromethane

24.84 °C

Kuila, Dilip Kumar; Lahiri

Journal of the Indian Chemical Society, 2008 , vol. 85, # 8 p. 830 - 835 Title/Abstract Full Text View citing articles Show Details

Association with compound

α-naphthol

tetrachloromethane

24.84 °C

Kuila, Dilip Kumar; Lahiri

Journal of the Indian Chemical Society, 2008 , vol. 85, # 8 p. 830 - 835 Title/Abstract Full Text View citing articles Show Details

Association with compound

β-naphthol

tetrachloromethane

24.84 °C

Kuila, Dilip Kumar; Lahiri

Journal of the Indian Chemical Society, 2008 , vol. 85, # 8 p. 830 - 835 Title/Abstract Full Text View citing articles Show Details

Association with compound

methanol

tetrachloromethane

24.84 °C

Kuila, Dilip Kumar; Lahiri

Journal of the Indian Chemical Society, 2008 , vol. 85, # 8 p. 830 - 835 Title/Abstract Full Text View citing articles

Reference

Show Details

Association with compound

ethanol

tetrachloromethane

Kuila, Dilip Kumar; Lahiri

Journal of the Indian Chemical Society, 2008 , vol. 85, # 8 p. 830 - 835 Title/Abstract Full Text View citing articles Show Details

24.84 °C

Chromatographic Data (1) Chromatographic data

Reference

TLC (Thin layer chromatography)

Ghosh, Suman Kr; Nagarajan, Rajagopal

RSC Advances, 2016 , vol. 6, # 33 p. 27378 - 27387 Title/Abstract Full Text View citing articles Show Details

Crystal Phase (1) Description (Crystal Phase)

Reference

Crystal habit

Jordan

Journal of Pharmaceutical Sciences, 1993 , vol. 82, # 12 p. 1269 - 1271 Title/Abstract Full Text View citing articles Show Details

Crystal Property Description (4) Colour & Other Properties

Location

Reference

white

supporting information

Shen, Guanshuo; Zhou, Haifeng; Sui, Yuebo; Liu, Qixing; Zou, Kun

Tetrahedron Letters, 2016 , vol. 57, # 5 p. 587 - 590 Title/Abstract Full Text View citing articles Show Details

Xu, Wei; Zhu, Xiao-Rui; Qian, Peng-Cheng; Zhang, Xing-Guo; Deng, Chen-Liang

Synlett, 2016 , vol. 27, # 20 art. no. ST-2016-W0432-L, p. 2851 - 2857 Title/Abstract Full Text Show Details

yellow

Ghosh, Suman Kr; Nagarajan, Rajagopal

RSC Advances, 2016 , vol. 6, # 33 p. 27378 - 27387 Title/Abstract Full Text View citing articles Show Details

white

Wang, Long; Wang, Ying; Chen, Min; Ding, Ming-Wu

Advanced Synthesis and Catalysis, 2014 , vol. 356, # 5 p. 1098 - 1104 Title/Abstract Full Text View citing articles Show Details

Kumar, Dinesh; Jadhavar, Pradeep S.; Nautiyal, Manesh; Sharma, Himanshu; Meena, Prahlad K.; Adane, Legesse; Pancholia, Sahaj; Chakraborti, Asit K.

RSC Advances, 2015 , vol. 5, # 39 p. 30819 - 30825 Title/Abstract Full Text View citing articles Show Details

white

supporting information

Fang, Jie; Zhou, Jianguang

Organic and Biomolecular Chemistry, 2012 , vol. 10, # 12 p. 2389 - 2391 Title/Abstract Full Text View citing articles Show Details

Dissociation Exponent (1) Comment (Dissociation Exponent)

Reference

(pk')pKa = 2.35

Nowak et al.

Arzneimittel Forschung, 1966 , vol. 16, p. 407,408 Full Text Show Details

Electrochemical Behaviour (1) Description (Electrochemical Behaviour)

Reference

Polarography

Pflegel; Wagner

Pharmazie, 1967 , vol. 22, p. 643,649 Full Text Show Details

Electrochemical Characteristics (1) Description (Electrochemical Characteristics)

Reference

polarographic half-wave potential

Pricken; Pflegel

Pharmazie, 1988 , vol. 43, # 10 p. 725 - 726

Title/Abstract Full Text View citing articles Show Details

Further Information (5) Description (Further Information)

Reference

Further information

Peiker et al.

Pharmazie, 1979 , vol. 34, p. 244,245 Full Text Show Details

Further information

Kirmani; Ahmed

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1978 , vol. 16, p. 526 Full Text Show Details

Further information

Pfeifer et al.

Pharmazie, 1974 , vol. 29, p. 765,766 - 769 Full Text View citing articles Show Details

Further information

Fazzari et al.

Journal - Association of Official Analytical Chemists, 1968 , vol. 51, p. 1154,1157 Full Text Show Details

Further information

Zotta et al.

Farmacia (Bucharest, Romania), 1964 , vol. 12, p. 599,603 Full Text Show Details

Liquid/Liquid Systems (MCS) (2) Description (Liquid/Liquid Systems (MCS))

Partner (Liquid/Liquid Systems (MCS))

Reference

Distribution between solvent 1 + 2

octanol; H2O

Hansch; Bjorkroth; Leo

Journal of Pharmaceutical Sciences, 1987 , vol. 76, # 9 p. 663 - 687 Title/Abstract Full Text View citing articles Show Details

Distribution between solvent 1 + 2

1) aqueous buffer solution 2) ether

Muller

Pharmazie, 1983 , vol. 38, # 9 p. 596 - 597 Title/Abstract Full Text View citing articles Show Details

Liquid/Solid Systems (MCS) (1) Description (Liquid/Solid Systems (MCS))

Reference

Eutectic

Brandstaetter-Kuhnert et al.

Scientia Pharmaceutica, 1963 , vol. 31, p. 140,146 Full Text Show Details

Optics (2) Description (Optics)

Reference

Crystal refractive indices

Jordan

Journal of Pharmaceutical Sciences, 1993 , vol. 82, # 12 p. 1269 - 1271 Title/Abstract Full Text View citing articles Show Details

Natural birefringence

Jordan

Journal of Pharmaceutical Sciences, 1993 , vol. 82, # 12 p. 1269 - 1271 Title/Abstract Full Text View citing articles Show Details

Solubility (MCS) (2) Comment (Solubility (MCS))

Reference

Schnellbach; Houta

Pharmaceutica Acta Helvetiae, 1972 , vol. 47, p. 75,76,78-82 Full Text Show Details

ll. in Ethylenchlorid; l. in Hexan, Alkoholen u. Saeuren; unl. in W. (S.62,65)

Akagi et al.

Chemical and Pharmaceutical Bulletin, 1963 , vol. 11, p. 58,60 Full Text Show Details

Spectra

NMR Spectroscopy (17) Description (NMR Spectroscopy)

Nucleus (NMR Spectroscopy)

Solvents (NMR Spectroscopy)

Chemical shifts

Chemical shifts Spectrum

Temperature (NMR Spectroscopy)

Frequency (NMR Spectroscopy)

Location

Comment (NMR Spectroscopy)

chloroform-d1

400 MHz

Kumar, Dinesh; Jadhavar, Pradeep S.; Nautiyal, Manesh; Sharma, Himanshu; Meena, Prahlad K.; Adane, Legesse; Pancholia, Sahaj; Chakraborti, Asit K.

RSC Advances, 2015 , vol. 5, # 39 p. 30819 30825 Title/Abstract Full Text View citing articles Show Details

Ghosh, Suman Kr; Nagarajan, Rajagopal

RSC Advances, 2016 , vol. 6, # 33 p. 27378 27387 Title/Abstract Full Text View citing articles Show Details

chloroform-d1

21.04 °C

400 MHz

supporting information

Shen, Guanshuo; Zhou, Haifeng; Sui, Yuebo; Liu, Qixing; Zou, Kun

Tetrahedron Letters, 2016 , vol. 57, # 5 p. 587 - 590 Title/Abstract Full Text View citing articles Show Details

Chemical shifts Spectrum

13C

chloroform-d1

21.14 °C

100 MHz

supporting information

Shen, Guanshuo; Zhou, Haifeng; Sui, Yuebo; Liu, Qixing; Zou, Kun

Tetrahedron Letters, 2016 , vol. 57, # 5 p. 587 - 590 Title/Abstract Full Text View citing articles Show Details

Chemical shifts

13C

chloroform-d1

100 MHz

Ghosh, Suman Kr; Nagarajan, Rajagopal

RSC Advances, 2016 , vol. 6, # 33 p. 27378 27387 Title/Abstract Full Text View citing articles Show Details

Chemical shifts Spectrum

chloroform-d1

500 MHz

supporting information

Xu, Wei; Zhu, Xiao-Rui; Qian, Peng-Cheng; Zhang, Xing-Guo; Deng, Chen-Liang

Synlett, 2016 , vol. 27, # 20 art. no. ST-2016W0432-L, p. 2851 - 2857 Title/Abstract Full Text Show Details

Chemical shifts Spectrum

13C

chloroform-d1

125 MHz

supporting information

Xu, Wei; Zhu, Xiao-Rui; Qian, Peng-Cheng; Zhang, Xing-Guo; Deng, Chen-Liang

Synlett, 2016 , vol. 27, # 20 art. no. ST-2016W0432-L, p. 2851 - 2857 Title/Abstract Full Text Show Details

Chemical shifts Spectrum

13C

chloroform-d1

100 MHz

supporting information

Xu, Lanting; Jiang, Yongwen; Ma, Dawei

Organic Letters, 2012 , vol. 14, # 4 p. 1150 1153 Title/Abstract Full Text View citing articles Show Details

Wang, Long; Wang, Ying; Chen, Min; Ding, Ming-Wu

Advanced Synthesis and Catalysis, 2014 , vol. 356, # 5 p. 1098 - 1104 Title/Abstract Full Text View citing articles Show Details

Chemical shifts Spectrum

chloroform-d1

600 MHz

supporting information

Wang, Long; Wang, Ying; Chen, Min; Ding, Ming-Wu

Advanced Synthesis and Catalysis, 2014 , vol. 356, # 5 p. 1098 - 1104 Title/Abstract Full Text View citing articles Show Details

Chemical shifts Spectrum

chloroform-d1

400 MHz

supporting information

Xu, Lanting; Jiang, Yongwen; Ma, Dawei

Organic Letters, 2012 , vol. 14, # 4 p. 1150 1153 Title/Abstract Full Text View citing articles Show Details

Chemical shifts Spectrum

dimethylsulfoxided6

400 MHz

supporting information

Fang, Jie; Zhou, Jianguang

Organic and Biomolecular Chemistry, 2012 , vol. 10, # 12 p. 2389 - 2391 Title/Abstract Full Text View citing articles

Reference

Show Details

Chemical shifts Spectrum

13C

dimethylsulfoxided6

100 MHz

supporting information

Fang, Jie; Zhou, Jianguang

Organic and Biomolecular Chemistry, 2012 , vol. 10, # 12 p. 2389 - 2391 Title/Abstract Full Text View citing articles Show Details

Spectrum

CDCl3

26.85 °C

400.132 MHz

Jeong, Jae Uk; Chen, Xiaohong; Rahman, Attiq; Yamashita, Dennis S.; Luengo, Juan I.

Organic Letters, 2004 , vol. 6, # 6 p. 1013 1016 Title/Abstract Full Text View citing articles Show Details

Chemical shifts

13C

CDCl3

Jeong, Jae Uk; Chen, Xiaohong; Rahman, Attiq; Yamashita, Dennis S.; Luengo, Juan I.

Organic Letters, 2004 , vol. 6, # 6 p. 1013 1016 Title/Abstract Full Text View citing articles Show Details

Chemical shifts

dimethylsulfoxided6

400 MHz

Jeong, Jae Uk; Chen, Xiaohong; Rahman, Attiq; Yamashita, Dennis S.; Luengo, Juan I.

Organic Letters, 2004 , vol. 6, # 6 p. 1013 1016 Title/Abstract Full Text View citing articles Show Details

Chemical shifts

various solvent(s)

Mannschreck; Koller; Stuhler; et al.

European Journal of Medicinal Chemistry, 1984 , vol. 19, # 4 p. 381 - 383 Title/Abstract Full Text View citing articles Show Details

NMR

Preuss; Hoffmann-Pinther; Achenbach; Friebolin

Die Pharmazie, 1970 , vol. 25, # 12 p. 752 759 Title/Abstract Full Text View citing articles Show Details

Soliman; Shafik; Elnenaey

Journal of Pharmaceutical Sciences, 1978 , vol. 67, # 3 p. 411 - 413 Title/Abstract Full Text View citing articles Show Details

Brine; Coleman; Carroll

Journal of Heterocyclic Chemistry, 1979 , vol. 16, # 1 p. 25 - 28 Title/Abstract Full Text View citing articles Show Details

Singh; Parmar; Stenberg; Akers

Journal of Heterocyclic Chemistry, 1978 , vol. 15, # 1 p. 53 - 56 Title/Abstract Full Text View citing articles Show Details

Spectrum

Untersuchung

AKAGI; OKETANI; YAMANE

Chemical and pharmaceutical bulletin, 1963 , vol. 11, p. 1216 - 1217 Title/Abstract Full Text View citing articles Show Details

IR Spectroscopy (4) Description (IR Spectroscopy)

Solvent (IR Spectroscopy)

Bands

potassium bromide

Kumar, Dinesh; Jadhavar, Pradeep S.; Nautiyal, Manesh; Sharma, Himanshu; Meena, Prahlad K.; Adane, Legesse; Pancholia, Sahaj; Chakraborti, Asit K.

RSC Advances, 2015 , vol. 5, # 39 p. 30819 - 30825 Title/Abstract Full Text View citing articles Show Details

Ghosh, Suman Kr; Nagarajan, Rajagopal

RSC Advances, 2016 , vol. 6, # 33 p. 27378 - 27387 Title/Abstract Full Text View citing articles Show Details

Bands

film

Jeong, Jae Uk; Chen, Xiaohong; Rahman, Attiq; Yamashita, Dennis S.; Luengo, Juan I.

Organic Letters, 2004 , vol. 6, # 6 p. 1013 - 1016 Title/Abstract Full Text View citing articles Show Details

Reference

Poehlmann; Pfeifer

Pharmazie, 1975 , vol. 30, # 2 p. 87 - 91 Title/Abstract Full Text View citing articles Show Details

Soliman

Synthesis, 1979 , vol. No 10, p. 803 - 804 Title/Abstract Full Text View citing articles Show Details

Brown; Smart

Journal of Pharmacy and Pharmacology, 1969 , vol. 21, p. 466,467 Full Text Show Details

Soliman; Shafik; Elnenaey

Journal of Pharmaceutical Sciences, 1978 , vol. 67, # 3 p. 411 - 413 Title/Abstract Full Text View citing articles Show Details

Preuss et al.

Arzneimittel Forschung, 1966 , vol. 16, p. 395,400 Full Text Show Details

Murata; Yamamoto

Chemical and Pharmaceutical Bulletin, 1970 , vol. 18, p. 133,134 Full Text Show Details

Spectrum

Pflegel; Wagner

Pharmazie, 1967 , vol. 22, p. 643,649 Full Text Show Details

Toyoshima et al.

Yakugaku Zasshi, 1965 , vol. 85, p. 507,510 Chem.Abstr., 1965 , vol. 63, # 7009 Full Text Show Details

Fazzari et al.

Journal - Association of Official Analytical Chemists, 1968 , vol. 51, p. 1154,1157 Full Text Show Details

Mass Spectrometry (8) Comment (Mass Spectrometry)

Description (Mass Spectrometry)

Location

high resolution mass spectrometry (HRMS) electrospray ionisation (ESI) fragmentation pattern spectrum

supporting information

Shen, Guanshuo; Zhou, Haifeng; Sui, Yuebo; Liu, Qixing; Zou, Kun

Tetrahedron Letters, 2016 , vol. 57, # 5 p. 587 - 590 Title/Abstract Full Text View citing articles Show Details

high resolution mass spectrometry (HRMS) electrospray ionisation (ESI) time-of-flight mass spectra (TOFMS) spectrum

Ghosh, Suman Kr; Nagarajan, Rajagopal

RSC Advances, 2016 , vol. 6, # 33 p. 27378 - 27387 Title/Abstract Full Text View citing articles Show Details

electron impact (EI) spectrum

supporting information

Xu, Wei; Zhu, Xiao-Rui; Qian, Peng-Cheng; Zhang, Xing-Guo; Deng, Chen-Liang

Synlett, 2016 , vol. 27, # 20 art. no. ST-2016-W0432-L, p. 2851 - 2857 Title/Abstract Full Text Show Details

APCI (atmospheric pressure chemical ionization) liquid chromatography mass spectrometry (LCMS) spectrum

Kumar, Dinesh; Jadhavar, Pradeep S.; Nautiyal, Manesh; Sharma, Himanshu; Meena, Prahlad K.; Adane, Legesse; Pancholia, Sahaj; Chakraborti, Asit K.

RSC Advances, 2015 , vol. 5, # 39 p. 30819 - 30825 Title/Abstract Full Text View citing articles Show Details

HRMS (High resolution mass spectrometry) ESI (Electrospray ionisation) Spectrum

supporting information

Xu, Lanting; Jiang, Yongwen; Ma, Dawei

Organic Letters, 2012 , vol. 14, # 4 p. 1150 - 1153 Title/Abstract Full Text View citing articles Show Details

Fang, Jie; Zhou, Jianguang

Organic and Biomolecular Chemistry, 2012 , vol. 10, # 12 p. 2389 - 2391 Title/Abstract Full Text View citing articles Show Details

MALDI-TOF (Matrix assisted laser desorption ionization - time of flight) QIT (quadrupole ion trap) CID (collision-induced dissociation) Spectrum

Porta, Tiffany; Grivet, Chantal; Knochenmuss, Richard; Varesio, Emmanuel; Hopfgartner, Gerard

Journal of Mass Spectrometry, 2011 , vol. 46, # 2 p. 144 - 152 Title/Abstract Full Text View citing articles Show Details

spectrum electron impact (EI)

collisional activation

Ramana; Kantharaj

Journal of Mass Spectrometry, 1995 , vol. 30, # 2 p. 262 - 268 Title/Abstract Full Text View citing articles Show Details

Preuss; Hoffmann-Pinther; Achenbach; Friebolin

Die Pharmazie, 1970 , vol. 25, # 12 p. 752 - 759 Title/Abstract Full Text View citing articles Show Details

Pfeifer et al.

Pharmazie, 1974 , vol. 29, p. 765,766 - 769 Full Text View citing articles Show Details

Reference

Bogentoft; Ericsson; Danielsson

Acta Pharmaceutica Suecica, 1974 , vol. 11, # 6 p. 513 - 522 Title/Abstract Full Text View citing articles Show Details

Kirmani; Ahmed

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1978 , vol. 16, p. 526 Full Text Show Details

Peiker et al.

Pharmazie, 1979 , vol. 34, p. 244,245 Full Text Show Details

Soliman; Shafik; Elnenaey

Journal of Pharmaceutical Sciences, 1978 , vol. 67, # 3 p. 411 - 413 Title/Abstract Full Text View citing articles Show Details

UV/VIS Spectroscopy (12) Description (UV/VIS Spectroscopy)

Solvent (UV/VIS Spectroscopy)

Absorption Maxima (UV/VIS)

water

265 nm

Kuila, Dilip Kumar; Lahiri

Journal of the Indian Chemical Society, 2008 , vol. 85, # 8 p. 830 - 835 Title/Abstract Full Text View citing articles Show Details

methanol

275 nm

Kuila, Dilip Kumar; Lahiri

Journal of the Indian Chemical Society, 2008 , vol. 85, # 8 p. 830 - 835 Title/Abstract Full Text View citing articles Show Details

ethanol

277 nm

Kuila, Dilip Kumar; Lahiri

Journal of the Indian Chemical Society, 2008 , vol. 85, # 8 p. 830 - 835 Title/Abstract Full Text View citing articles Show Details

isopropyl alcohol

266 nm

Kuila, Dilip Kumar; Lahiri

Journal of the Indian Chemical Society, 2008 , vol. 85, # 8 p. 830 - 835 Title/Abstract Full Text View citing articles Show Details

chloroform

235 nm 240 nm 268 nm

Kuila, Dilip Kumar; Lahiri

Journal of the Indian Chemical Society, 2008 , vol. 85, # 8 p. 830 - 835 Title/Abstract Full Text View citing articles Show Details

Spectrum

tetrachloromethane

270 nm 307 nm 319 nm

Kuila, Dilip Kumar; Lahiri

Journal of the Indian Chemical Society, 2008 , vol. 85, # 8 p. 830 - 835 Title/Abstract Full Text View citing articles Show Details

hexane

250 nm 256 nm 262 nm 268 nm

Kuila, Dilip Kumar; Lahiri

Journal of the Indian Chemical Society, 2008 , vol. 85, # 8 p. 830 - 835 Title/Abstract Full Text View citing articles Show Details

benzene

256 nm 269 nm 272 nm 279 nm

Kuila, Dilip Kumar; Lahiri

Journal of the Indian Chemical Society, 2008 , vol. 85, # 8 p. 830 - 835 Title/Abstract Full Text View citing articles Show Details

UV/VIS

Poehlmann; Pfeifer

Pharmazie, 1975 , vol. 30, # 2 p. 87 - 91 Title/Abstract Full Text View citing articles Show Details

Nowak et al.

Arzneimittel Forschung, 1966 , vol. 16, p. 407,408 Full Text Show Details

Schnellbach; Houta

Pharmaceutica Acta Helvetiae, 1972 , vol. 47, p. 75,76,78-82 Full Text Show Details

Preisser

Arzneimittel-Forschung/Drug Research, 1975 , vol. 25, # 3 p. 363 - 365 Title/Abstract Full Text View citing articles Show Details

Murata; Yamamoto

Chemical and Pharmaceutical Bulletin, 1970 , vol. 18, p. 133,134 Full Text Show Details

Absorption maxima

AKAGI; OKETANI; YAMANE

Chemical and pharmaceutical bulletin, 1963 , vol. 11, p. 1216 - 1217 Title/Abstract Full Text View citing articles Show Details

Brown; Smart

Journal of Pharmacy and Pharmacology, 1969 , vol. 21, p. 466,467 Full Text Show Details

Spectrum

Pflegel; Wagner

Pharmazie, 1967 , vol. 22, p. 643,649 Full Text Show Details

Reference

Grammaticakis

Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1961 , vol. 252, p. 4011 Full Text Show Details

Di Renzo

Bollettino chimico farmaceutico, 1969 , vol. 108, # 3 p. 200 - 204 Title/Abstract Full Text View citing articles Show Details

Toyoshima et al.

Yakugaku Zasshi, 1965 , vol. 85, p. 507,510 Chem.Abstr., 1965 , vol. 63, # 7009 Full Text Show Details

Fazzari et al.

Journal - Association of Official Analytical Chemists, 1968 , vol. 51, p. 1154,1157 Full Text Show Details

Akagi et al.

Chemical and Pharmaceutical Bulletin, 1963 , vol. 11, p. 58,60 Full Text Show Details

Absorption maxima

ethanol

226 nm 265 nm 305 nm 315.5 nm

Serventi; Marchesi

Bollettino Scientifico della Facolta di Chimica Industriale di Bologna, 1957 , vol. 15, p. 114 Full Text Show Details

Bioactivity Pharmacological Data (60) 1 of 60

Comment (Pharmacological Data)

Bioactivities present

Reference

Hisano; Ichikawa; Nakagawa; Tsuji

Chemical and Pharmaceutical Bulletin, 1975 , vol. 23, # 9 p. 1910 - 1916 Title/Abstract Full Text View citing articles Show Details

The Sherwin-Williams Company

Patent: US3989698 A1, 1976 ; Title/Abstract Full Text Show Details

Sianesi; Redaelli; Magistretti; Massarani

Journal of Medicinal Chemistry, 1973 , vol. 16, # 10 p. 1133 - 1137 Title/Abstract Full Text View citing articles Show Details

Ager; Harrison; Kennewell; Taylor

Journal of Medicinal Chemistry, 1977 , vol. 20, # 3 p. 379 - 386 Title/Abstract Full Text View citing articles Show Details

Preuss; Hoffmann-Pinther; Achenbach; Friebolin

Die Pharmazie, 1970 , vol. 25, # 12 p. 752 - 759 Title/Abstract Full Text View citing articles Show Details

BOLTZE; DELL; LEHWALD; LORENZ; RUEBERG-SCHWEER

Arzneimittel-Forschung, 1963 , vol. 13, p. 688 - 701 Title/Abstract Full Text View citing articles Show Details

Aventis Pharmaceuticals, Inc.

Patent: US6984620 B1, 2006 ; Title/Abstract Full Text Show Details

Renshaw, Perry F.; Cohen, Bruce M.

Patent: US2006/39890 A1, 2006 ; Title/Abstract Full Text Show Details

Kacker; Zaheer

Journal of the Indian Chemical Society, 1951 , vol. 28, p. 344 Full Text Show Details

Patel et al. bzw. Janicki; Gilpin

in K. Florey, Analytical Profiles of Drug Substances, Bd. 4 <New York 1975> S. 246 bzw. Bd. 7 <New York 1978> S. 171 Full Text Show Details

Serventi; Marchesi

Bollettino Scientifico della Facolta di Chimica Industriale di Bologna, 1957 , vol. 15, p. 114 Full Text Show Details

Pfeifer et al.

Pharmazie, 1974 , vol. 29, p. 765,766 - 769 Full Text View citing articles Show Details

Poehlmann; Pfeifer

Pharmazie, 1975 , vol. 30, # 2 p. 87 - 91 Title/Abstract Full Text View citing articles Show Details

Poehlmann; Pfeifer

Pharmazie, 1975 , vol. 30, # 3 p. 162 - 167 Title/Abstract Full Text View citing articles Show Details

Hardtmann et al.

Journal of Medicinal Chemistry, 1971 , vol. 14, p. 878,881 Full Text Show Details

Pflegel; Wagner

Pharmazie, 1967 , vol. 22, p. 643,649 Full Text Show Details

Klosa

Journal fuer Praktische Chemie (Leipzig), 1961 , vol. 14, p. 84

Full Text Show Details

Brandstaetter-Kuhnert et al.

Scientia Pharmaceutica, 1963 , vol. 31, p. 140,146 Full Text Show Details

Stefanova et al.

Pharmaceutical Chemistry Journal, 1973 , vol. 7, # 10 p. 626 Khimiko-Farmatsevticheskii Zhurnal, 1973 , vol. 7, # 10 p. 19 Full Text View citing articles Show Details

Andrisano; Chiesi

Ateneo Parmense, 1961 , vol. 32, p. 671 Chem.Abstr., 1963 , vol. 58, # 3428c Full Text Show Details

2 of 60

Comment (Pharmacological Data)

Bioactivities present

Reference

Soliman

Synthesis, 1979 , vol. No 10, p. 803 - 804 Title/Abstract Full Text View citing articles Show Details

Bogentoft; Ericsson; Danielsson

Acta Pharmaceutica Suecica, 1974 , vol. 11, # 6 p. 513 - 522 Title/Abstract Full Text View citing articles Show Details

Nowak et al.

Arzneimittel Forschung, 1966 , vol. 16, p. 407,408 Full Text Show Details

Sellers; Khouw; Dolman

Journal of Pharmaceutical Sciences, 1977 , vol. 66, # 11 p. 1640 - 1641 Title/Abstract Full Text View citing articles Show Details

Kirmani; Ahmed

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1978 , vol. 16, p. 526 Full Text Show Details

Grammaticakis

Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1961 , vol. 252, p. 4011 Full Text Show Details

MURATA; YAMAMOTO

Chemical and pharmaceutical bulletin, 1964 , vol. 12, p. 631 - 632 Title/Abstract Full Text View citing articles Show Details

AKAGI; OKETANI; YAMANE

Chemical and pharmaceutical bulletin, 1963 , vol. 11, p. 1216 - 1217 Title/Abstract Full Text View citing articles Show Details

Di Renzo

Bollettino chimico farmaceutico, 1969 , vol. 108, # 3 p. 200 - 204 Title/Abstract Full Text View citing articles Show Details

Moehrle; Seidel

Archiv der Pharmazie (Weinheim, Germany), 1976 , vol. 309, p. 471,473,478 Full Text View citing articles Show Details

Brown; Smart

Journal of Pharmacy and Pharmacology, 1969 , vol. 21, p. 466,467 Full Text Show Details

Orgamol

Patent: GB982207 , 1965 ; Chem.Abstr., 1965 , vol. 62, # 16268e Full Text Show Details

Hans Starke

Patent: DD35123 , 1962 ; Chem.Abstr., 1965 , vol. 63, # 8377d Full Text Show Details

Peiker et al.

Pharmazie, 1979 , vol. 34, p. 244,245 Full Text Show Details

Chinoin Gyog. es Veg. Termekek Gyara Rt.

Patent: HU149660 , 1960 ; Chem.Abstr., 1963 , vol. 58, # 4585d Full Text Show Details

The Sherwin-Williams Co.(USA)

Patent: FR2301524DE2556590 , 1976 ; Chem.Abstr., vol. 85, # 160115z Full Text Show Details

Stroh

Patent: DD65928 , 1968 ; Chem.Abstr., 1969 , vol. 71, # 124485x Full Text Show Details

Schnellbach; Houta

Pharmaceutica Acta Helvetiae, 1972 , vol. 47, p. 75,76,78-82 Full Text Show Details

Warner Lambert Pharm. Co.

Patent: GB1114920 , 1966 ; Chem.Abstr., 1968 , vol. 69, # 59274v Full Text Show Details

Nord. Droge and Kem. AIS

Patent: NL295501 , 1965 ; Chem.Abstr., 1965 , vol. 63, # 18113g Full Text Show Details

3 of 60

4 of 60

Comment (Pharmacological Data)

Bioactivities present

Reference

Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.

Patent: AT235839 , 1962 ; Chem.Abstr., 1965 , vol. 62, # 575c Full Text Show Details

Petyunin; Kozhevnikov

Meditsinskaya Promyshlennost SSSR, 1966 , vol. 20, # 4 p. 13,14,15 Chem.Abstr., 1966 , vol. 65, # 7176b Full Text Show Details

Soliman; Shafik; Elnenaey

Journal of Pharmaceutical Sciences, 1978 , vol. 67, # 3 p. 411 - 413 Title/Abstract Full Text View citing articles Show Details

Yamamoto; Koyama; Eyanagi; Yoshida

Chemical and Pharmaceutical Bulletin, 1977 , vol. 25, # 3 p. 397 - 400 Title/Abstract Full Text View citing articles Show Details

Preuss et al.

Arzneimittel Forschung, 1966 , vol. 16, p. 395,400 Full Text Show Details

Toyoshima et al.

Yakugaku Zasshi, 1965 , vol. 85, p. 507,510 Chem.Abstr., 1965 , vol. 63, # 7009 Full Text Show Details

Brine; Coleman; Carroll

Journal of Heterocyclic Chemistry, 1979 , vol. 16, # 1 p. 25 - 28 Title/Abstract Full Text View citing articles Show Details

Singh; Parmar; Stenberg; Akers

Journal of Heterocyclic Chemistry, 1978 , vol. 15, # 1 p. 53 - 56 Title/Abstract Full Text View citing articles Show Details

Zotta et al.

Farmacia (Bucharest, Romania), 1964 , vol. 12, p. 599,603 Full Text Show Details

Errede et al.

Journal of Organic Chemistry, 1976 , vol. 41, p. 1765 Full Text View citing articles Show Details

Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.

Patent: HU150883 , 1962 ; Chem.Abstr., 1964 , vol. 60, # 6855c Full Text Show Details

Klosa

Journal fuer Praktische Chemie (Leipzig), 1963 , vol. 20, p. 283 Full Text Show Details

General Anilin and Film Corp.

Patent: US3213094 , 1963 ; Chem.Abstr., 1966 , vol. 64, # 2107b Full Text Show Details

Preisser

Arzneimittel-Forschung/Drug Research, 1975 , vol. 25, # 3 p. 363 - 365 Title/Abstract Full Text View citing articles Show Details

Manhas; Amin; Rao

Synthesis, 1977 , vol. No. 5, p. 309 - 310 Title/Abstract Full Text View citing articles Show Details

Fazzari et al.

Journal - Association of Official Analytical Chemists, 1968 , vol. 51, p. 1154,1157 Full Text Show Details

Gronowitz et al.

Acta Pharmaceutica Suecica, 1968 , vol. 5, p. 563,567,570 Full Text View citing articles Show Details

Akagi et al.

Chemical and Pharmaceutical Bulletin, 1963 , vol. 11, p. 58,60 Full Text Show Details

Parmar; Kishor; Seth; Arora

Journal of medicinal chemistry, 1969 , vol. 12, # 1 p. 138 - 141 Title/Abstract Full Text View citing articles Show Details

Pesson; Richer

Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1968 , vol. 266, p. 1787 Full Text Show Details

Comment (Pharmacological Data)

Bioactivities present

Reference

Moskalenko; Savel'eva

Chemistry of Heterocyclic Compounds (New York, NY, United States), 1969 , vol. 5, p. 264 Khimiya Geterotsiklicheskikh Soedinenii, 1969 , vol. 5, p. 348 Full Text Show Details

Murata; Yamamoto

Chemical and Pharmaceutical Bulletin, 1970 , vol. 18, p. 133,134 Full Text Show Details

Petjunin; Koshewnikow

Biol. Akt. Soedin., 1965 , p. 152,153,154,155 Full Text Show Details

Wolfe, James F.; Rathman, Terry L.; Sleevi, Mark C.; Campbell, James A.; Greenwood, Thomas D.

Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 161 - 166

Title/Abstract Full Text View citing articles Show Details

Rathman, Terry L.; Sleevi, Mark C.; Krafft, Marie E.; Wolfe, James F.

Journal of Organic Chemistry, 1980 , vol. 45, # 11 p. 2169 - 2176 Title/Abstract Full Text View citing articles Show Details

Mannschreck; Koller; Stuhler; et al.

European Journal of Medicinal Chemistry, 1984 , vol. 19, # 4 p. 381 - 383 Title/Abstract Full Text View citing articles Show Details

Pohlmann; Theil; Otto

Pharmazie, 1986 , vol. 41, # 6 p. 390 - 394 Title/Abstract Full Text View citing articles Show Details

Pohlmann; Theil; Pfeifer

Pharmazie, 1985 , vol. 40, # 4 p. 269 - 269 Title/Abstract Full Text View citing articles Show Details

Theil; Pohlmann; Pfeifer; Franke

Pharmazie, 1985 , vol. 40, # 5 p. 328 - 331 Title/Abstract Full Text View citing articles Show Details

Philippson Chr.; Schmiedel

Pharmazie, 1983 , vol. 38, # 3 p. 181 - 182 Title/Abstract Full Text View citing articles Show Details

Fatmi, Aqeel A.; Vaidya, Niteen A.; Iturrian, W. B.; Blanton, C. DeWitt

Journal of Medicinal Chemistry, 1984 , vol. 27, # 6 p. 772 - 778 Title/Abstract Full Text View citing articles Show Details

Buyuktimkin; Ekinci; Otuk

Journal of Pharmaceutical Sciences, 1992 , vol. 81, # 11 p. 1092 - 1094 Title/Abstract Full Text View citing articles Show Details

Pricken; Pflegel

Pharmazie, 1988 , vol. 43, # 10 p. 725 - 726 Title/Abstract Full Text View citing articles Show Details

Hilmy, Khalid Mohamed Hassan; Mogensen, Joergen; Pedersen, Erik B.

Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1987 , vol. 41, p. 467 - 468 Title/Abstract Full Text Show Details

Nielsen, Knud Erik; Pedersen, Erik B.

Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1980 , vol. 34, # 9 p. 637 - 642 Title/Abstract Full Text Show Details

Vaidya; Panos; Kite; Iturrian; Blanton Jr.

Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1422 - 1425 Title/Abstract Full Text View citing articles Show Details

Soliman; Stadlbauer; Kappe

Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1981 , vol. 36, # 2 p. 252 - 256 Title/Abstract Full Text View citing articles Show Details

Muller

Pharmazie, 1983 , vol. 38, # 9 p. 596 - 597 Title/Abstract Full Text View citing articles Show Details

Fromming; Ditter; Horn

Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 7 p. 738 - 743 Title/Abstract Full Text View citing articles Show Details

Houlihan, William J.; Gogerty, John H.; Ryan, Eileen A.; Schmitt, Gemma

Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 28 - 31 Title/Abstract Full Text View citing articles Show Details

5 of 60

Comment (Pharmacological Data)

Bioactivities present

Reference

Jordan

Journal of Pharmaceutical Sciences, 1993 , vol. 82, # 12 p. 1269 - 1271 Title/Abstract Full Text View citing articles Show Details

Hansch; Bjorkroth; Leo

Journal of Pharmaceutical Sciences, 1987 , vol. 76, # 9 p. 663 - 687 Title/Abstract Full Text View citing articles Show Details

Gupta; Bhargava; Ali

Journal of Pharmacy and Pharmacology, 1982 , vol. 34, # 11 p. 744 - 746 Title/Abstract Full Text View citing articles Show Details

Ramana; Kantharaj

Journal of Mass Spectrometry, 1995 , vol. 30, # 2 p. 262 - 268 Title/Abstract Full Text View citing articles Show Details

Shivarama Holla; Akberali; Shivananda

Bollettino Chimico Farmaceutico, 1996 , vol. 135, # 5 p. 351 - 354 Title/Abstract Full Text View citing articles Show Details

Schleuder; Duerrbeck; Jira

Pharmazie, 1998 , vol. 53, # 6 p. 381 - 386 Title/Abstract Full Text View citing articles Show Details

Holla, B. Shivarama; Akberali; Shivananda

Journal of the Indian Chemical Society, 1998 , vol. 75, # 9 p. 534 - 535 Title/Abstract Full Text View citing articles Show Details

Chenard; Menniti; Pagnozzi; Shenk; Ewing; Welch

Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 11 p. 1203 - 1205 Title/Abstract Full Text View citing articles Show Details

Welch; Ewing; Huang; Menniti; Pagnozzi; Kelly; Seymour; Guanowsky; Guhan; Guinn; Critchett; Lazzaro; Ganong; DeVries; Staigers; Chenard

Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 2 p. 177 - 181 Title/Abstract Full Text View citing articles Show Details

Jeong, Jae Uk; Chen, Xiaohong; Rahman, Attiq; Yamashita, Dennis S.; Luengo, Juan I.

Organic Letters, 2004 , vol. 6, # 6 p. 1013 - 1016 Title/Abstract Full Text View citing articles Show Details

Obach, R. Scott; Huynh, Phuong; Allen, Mary C.; Beedham, Christine

Journal of Clinical Pharmacology, 2004 , vol. 44, # 1 p. 7 - 19 Title/Abstract Full Text View citing articles Show Details

White, David C.; Greenwood, Thomas D.; Downey, Aaron L.; Bloomquist, Jeffrey R.; Wolfe, James F.

Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 21 p. 5711 - 5717 Title/Abstract Full Text View citing articles Show Details

Salehi, Peyman; Dabiri, Minoo; Zolfigol, Mohammad Ali; Baghbanzadeh, Mostafa

Tetrahedron Letters, 2005 , vol. 46, # 41 p. 7051 - 7053 Title/Abstract Full Text View citing articles Show Details

Ator, Nancy A.; Griffiths, Roland R.

Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 282, # 3 p. 1442 - 1457 Title/Abstract Full Text View citing articles Show Details

Votano, Joseph R.; Parham, Marc; Hall, L. Mark; Hall, Lowell H.; Kier, Lemont B.; Oloff, Scott; Tropsha, Alexander

Journal of Medicinal Chemistry, 2006 , vol. 49, # 24 p. 7169 - 7181 Title/Abstract Full Text View citing articles Show Details

Research Corporation

Patent: US4183931 A1, 1980 ; Title/Abstract Full Text Show Details

PFIZER LIMITED

Patent: WO2008/135830 A1, 2008 ; Title/Abstract Full Text Show Details

Bristol, David William; King, Clifford Riley; Mitchener, JR., Joseph Pike; Audia, Vicki Haynes

Patent: US2008/293695 A1, 2008 ; Title/Abstract Full Text Show Details

Kuila, Dilip Kumar; Lahiri

Journal of the Indian Chemical Society, 2008 , vol. 85, # 8 p. 830 - 835 Title/Abstract Full Text View citing articles Show Details

Hydra Biosciences, Inc.

Patent: US2007/179164 A1, 2007 ; Title/Abstract Full Text Show Details

6 of 60

Comment (Pharmacological Data)

Bioactivities present

Reference

Porta, Tiffany; Grivet, Chantal; Knochenmuss, Richard; Varesio, Emmanuel; Hopfgartner, Gerard

Journal of Mass Spectrometry, 2011 , vol. 46, # 2 p. 144 - 152 Title/Abstract Full Text View citing articles Show Details

El-Azab, Adel S.; Eltahir, Kamal E.H.

Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 327 - 333 Title/Abstract Full Text View citing articles Show Details

Xu, Lanting; Jiang, Yongwen; Ma, Dawei

Organic Letters, 2012 , vol. 14, # 4 p. 1150 - 1153 Title/Abstract Full Text View citing articles Show Details

Fang, Jie; Zhou, Jianguang

Organic and Biomolecular Chemistry, 2012 , vol. 10, # 12 p. 2389 - 2391 Title/Abstract Full Text View citing articles Show Details

El-Azab, Adel S.; Eltahir, Kamal E.H.

Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 5 p. 1879 - 1885 Title/Abstract Full Text View citing articles Show Details

El-Azab, Adel S.; ElTahir, Kamal E.H.; Attia, Sabry M.

Monatshefte fur Chemie, 2011 , vol. 142, # 8 p. 837 - 848 Title/Abstract Full Text View citing articles Show Details

Benet, Leslie Z.; Broccatelli, Fabio; Oprea, Tudor I.

AAPS Journal, 2011 , vol. 13, # 4 p. 519 - 547 Title/Abstract Full Text View citing articles Show Details

El-Azab, Adel S.; ElTahir, Kamal E. H.

Medicinal Chemistry Research, 2012 , vol. 21, # 11 p. 3785 - 3796 Title/Abstract Full Text View citing articles Show Details

Hofrichter; Roesch; Schenk

Arzneimittel-Forschung, 1967 , vol. 17, # 2 p. 242 - 245 Title/Abstract Full Text View citing articles Show Details

Wolfe; Rathman; Sleevi; Campbell; Greenwood

Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 161 - 166 Title/Abstract Full Text Show Details

Houlihan; Gogerty; Ryan; Schmitt

Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 28 - 31 Title/Abstract Full Text Show Details

Fatmi; Vaidya; Iturrian; Blanton Jr.

Journal of Medicinal Chemistry, 1984 , vol. 27, # 6 p. 772 - 778 Title/Abstract Full Text Show Details

Bennett; Babington; Deacon; Eden; Kerestan; Leslie; Ryan; Mason; Minor

Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 490 - 496 Title/Abstract Full Text Show Details

Ekwall

Toxicology, 1980 , vol. 17, # 3 p. 273 - 295 Title/Abstract Full Text Show Details

Rastogi; Sinha; Bhargava

Indian Journal of Medical Research, 1979 , vol. 69, # 6 p. 1008 - 1010 Title/Abstract Full Text View citing articles Show Details

Tani; Yamada; Oine; Ochiai; Ishida; Inoue

Journal of Medicinal Chemistry, 1979 , vol. 22, # 1 p. 95 - 99 Title/Abstract Full Text Show Details

Hardtmann; Huegi

Journal of medicinal chemistry, 1971 , vol. 14, # 9 p. 878 - 882 Title/Abstract Full Text Show Details

Zayed, Mohamed F.; Ahmed, Hany E. A.; Omar, Abdel-Sattar M.; Abdelrahim, Adel S.; El-Adl, Khaled

Medicinal Chemistry Research, 2013 , vol. 22, # 12 p. 5823 - 5831 Title/Abstract Full Text View citing articles Show Details

Vanparia, Satish F.; Patel, Tarosh S.; Dixit, Ritu B.; Dixit, Bharat C.

Medicinal Chemistry Research, 2013 , vol. 22, # 11 p. 5184 - 5196 Title/Abstract Full Text View citing articles Show Details

Type: Review, Lab: EFF_071212, Owner: EFFECT, Number: 000, Revision: 07.12.2012 00:00:00 2012 Full Text Show Details

7 of 60

8 of 60

Comment (Pharmacological Data)

Bioactivities present

Reference

Jeffrey M. Liebman; Josef A. Schneider

Annual reports in medicinal chemistry, 1985 , vol. 20, p. 11 - 20 Title/Abstract Full Text Show Details

Joel G. Berger; Louis C. Iorio

Annual reports in medicinal chemistry, 1980 , vol. 15, p. 22 - 31 Title/Abstract Full Text Show Details

Cornelius K. Cain

Annual reports in medicinal chemistry, 1966 , vol. 2, p. 24 - 32 Title/Abstract Full Text Show Details

GELDMACHER-MALLINCKRODT; LAUTENBACH

Archiv für Toxikologie, 1963 , vol. 20, p. 31 - 37 Title/Abstract Full Text Show Details

ZILBERMINTS

Farmakologiia i toksikologiia, 1964 , vol. 27, p. 413 - 418 Title/Abstract Full Text View citing articles Show Details

Pharm Chem J, 1973 , vol. 7, p. 626 Full Text Show Details

Clarke's Analysis of Drugs and Poisons Full Text Show Details

Toxicology and applied pharmacology, 1959 , vol. 1, p. 42 Full Text Show Details

http://www2.siri.org/msds/tox/f/q122/q566.html Full Text Show Details

http://www.sdrl.com/druglist/methaqualone.html Full Text Show Details

Wang, Long; Wang, Ying; Chen, Min; Ding, Ming-Wu

Advanced Synthesis and Catalysis, 2014 , vol. 356, # 5 p. 1098 - 1104 Title/Abstract Full Text View citing articles Show Details

Kumar, Dinesh; Jadhavar, Pradeep S.; Nautiyal, Manesh; Sharma, Himanshu; Meena, Prahlad K.; Adane, Legesse; Pancholia, Sahaj; Chakraborti, Asit K.

RSC Advances, 2015 , vol. 5, # 39 p. 30819 - 30825 Title/Abstract Full Text View citing articles Show Details

Karinen, Ritva; Vindenes, Vigdis; Hasvold, Inger; Olsen, Kirsten Midtbøen; Christophersen, Asbjørg S.; Øiestad, Elisabeth

Drug Testing and Analysis, 2015 , vol. 7, # 7 p. 634 - 644 Title/Abstract Full Text View citing articles Show Details

Hammer, Harriet; Bader, Benjamin M.; Ehnert, Corina; Bundgaard, Christoffer; Bunch, Lennart; Hoestgaard-Jensen, Kirsten; Schroeder, Olaf H.-U.; Bastlund, Jesper F.; Gramowski-Voß, Alexandra; Jensen, Anders A.

Molecular Pharmacology, 2015 , vol. 88, # 2 p. 401 - 420 Title/Abstract Full Text View citing articles Show Details

Shen, Guanshuo; Zhou, Haifeng; Du, Peng; Liu, Sensheng; Zou, Kun; Uozumi, Yasuhiro

RSC Advances, 2015 , vol. 5, # 104 p. 85646 - 85651 Title/Abstract Full Text View citing articles Show Details

Rees Catalán, Andrés K.

Environmental Development, 2015 , vol. 16, p. 90 - 103 Title/Abstract Full Text View citing articles Show Details

Brown, Stanley S.; Goenechea, Sabino

Clinical Pharmacology and Therapeutics, 1973 , vol. 14, # 3 p. 314 - 324 Title/Abstract Full Text Show Details

Shen, Guanshuo; Zhou, Haifeng; Sui, Yuebo; Liu, Qixing; Zou, Kun

Tetrahedron Letters, 2016 , vol. 57, # 5 p. 587 - 590 Title/Abstract Full Text View citing articles Show Details

Tang, Magdalene H.Y.; Ching; Lee, Caroline Y.W.; Lam, Ying-Hoo; Mak, Tony W.L.

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2014 , vol. 969, p. 272 - 284 Title/Abstract Full Text View citing articles Show Details

Irei; Takami; Sadanaga; Nozoe; Yonemura; Bandow; Yokouchi

Atmospheric Chemistry and Physics Discussions, 2016 , vol. 2016 Title/Abstract Full Text Show Details

Comment (Pharmacological Data)

Bioactivities present

Reference

Uhlmann, Anne; Fouche, Jean-Paul; Koen, Nastassja; Meintjes, Ernesta M.; Wilson, Don; Stein, Dan J.

Psychiatry Research - Neuroimaging, 2016 , vol. 248, p. 30 - 38 Title/Abstract Full Text View citing articles Show Details

Issa, Mohamad; McHenry, Michael; Issa, Abdul Aziz; Blackwood, Roland Alexander

Infectious Disease Reports, 2015 , vol. 7, # 4 p. 81 - 86 Title/Abstract Full Text View citing articles Show Details

Komatsuh, Hiroko; Yagasaki, Kaori; Yamauchi, Hideko; Yamauchi, Teruo

Clinical Journal of Oncology Nursing, 2016 , vol. 20, # 1 p. 13 - 16 Title/Abstract Full Text View citing articles Show Details

Skalickova, Sylvie; Nejdl, Lukas; Kudr, Jiri; Ruttkay-Nedecky, Branislav; Jimenez, Ana Maria Jimenez; Kopel, Pavel; Kremplova, Monika; Masarik, Michal; Stiborova, Marie; Eckschlager, Tomas; Adam, Vojtech; Kizek, Rene

Sensors (Switzerland), 2016 , vol. 16, # 3 art. no. 290 Title/Abstract Full Text View citing articles Show Details

Liveri, Katerina; Constantinou, Maria A.; Afxentiou, Maria; Kanari, Popi

Forensic Science International, 2016 , vol. 265, p. 160 - 165 Title/Abstract Full Text View citing articles Show Details

Dahl, Ronald; Roberts, Graham; De Blic, Jacques; Canonica, G. Walter; Kleine-Tebbe, Jörg; Nolte, Hendrik; Lawton, Simon; Nelson, Harold S.

Allergy and Asthma Proceedings, 2016 , vol. 37, # 2 p. 92 - 104 Title/Abstract Full Text View citing articles Show Details

Kuang, Zhiming; Yung, Yuk L.

Geophysical Research Letters, 2000 , vol. 27, # 16 p. 2501 - 2504 Title/Abstract Full Text Show Details

Broséus, Julian; Gentile, Natacha; Esseiva, Pierre

Forensic Science International, 2016 , vol. 262, p. 73 - 83 Title/Abstract Full Text View citing articles Show Details

Ghosh, Suman Kr; Nagarajan, Rajagopal

RSC Advances, 2016 , vol. 6, # 33 p. 27378 - 27387 Title/Abstract Full Text View citing articles Show Details

Ullrich, Martin; Haša, Jan; Hanuš, Jaroslav; Šoóš, Miroslav; Štěpánek, František

Powder Technology, 2016 , vol. 295, p. 115 - 121 Title/Abstract Full Text View citing articles Show Details Eweas, Ahmad F.

Der Pharma Chemica, 2016 , vol. 8, # 2 p. 210 - 215 Title/Abstract Full Text View citing articles Show Details

Deb, Dipankar; Datta; Debbarma, Jaba; Deb, Sourabh

Biodiversitas, 2016 , vol. 17, # 1 p. 256 - 269 Title/Abstract Full Text View citing articles Show Details

Sampat, Andjoe; Lopatka, Martin; Sjerps, Marjan; Vivo-Truyols, Gabriel; Schoenmakers, Peter; van Asten, Arian

TrAC - Trends in Analytical Chemistry, 2016 , vol. 80, p. 345 - 363 Title/Abstract Full Text View citing articles Show Details

Rohokale, Rajendra S.; Kshirsagar, Umesh A.

Synthesis (Germany), 2016 , vol. 48, # 9 p. 1253 - 1268 Title/Abstract Full Text View citing articles Show Details

Bietz, Matthew J.; Hayes, Gillian R.; Morris, Margaret E.; Patterson, Heather; Stark, Luke

IEEE Pervasive Computing, 2016 , vol. 15, # 2 art. no. 7445780, p. 82 - 85 Title/Abstract Full Text View citing articles Show Details

Bardram, Jakob E.; Frost, Mads

IEEE Pervasive Computing, 2016 , vol. 15, # 2 art. no. 7445786, p. 70 - 78 Title/Abstract Full Text View citing articles Show Details

Khan, Imtiaz; Zaib, Sumera; Batool, Sadaf; Abbas, Naeem; Ashraf, Zaman; Iqbal, Jamshed; Saeed, Aamer

Bioorganic and Medicinal Chemistry, 2016 , vol. 24, # 11 p. 2361 - 2381 Title/Abstract Full Text View citing articles Show Details

Shirakawa, Seiji; Liu, Shiyao; Kaneko, Shiho

Chemistry - An Asian Journal, 2016 , vol. 11, # 3 p. 330 - 341 Title/Abstract Full Text View citing articles Show Details

Jimenez, Ana Maria Jimenez; Ruttkay-Nedecky, Branislav; Dostalova, Simona; Krejcova, Ludmila; Michalek, Petr; Richtera, Lukas; Adam, Vojtech

International Journal of Molecular Sciences, 2016 , vol. 17, # 5 art. no. 585 Title/Abstract Full Text View citing articles Show Details

Saloň, Ivan; Hanuš, Jaroslav; Ulbrich, Pavel; Štěpánek, František

Food and Bioproducts Processing, 2016 , vol. 99, p. 128 - 135 Title/Abstract Full Text View citing articles Show Details

9 of 60

Comment (Pharmacological Data)

Bioactivities present

Reference

Yang, Yunyun; Deng, Jiewei

TrAC - Trends in Analytical Chemistry, 2016 , vol. 82, p. 68 - 88 Title/Abstract Full Text View citing articles Show Details

Patel, Harun M.; Noolvi, Malleshappa N.; Shirkhedkar, Atul A.; Kulkarni, Abhijeet D.; Pardeshi, Chandrakantsing V.; Surana, Sanjay J.

RSC Advances, 2016 , vol. 6, # 50 p. 44435 - 44455 Title/Abstract Full Text View citing articles Show Details

Belkin, V. Sh.; Dyurgerov; Finaev; Soroko

Human Physiology, 2016 , vol. 42, # 2 p. 119 - 127 Title/Abstract Full Text View citing articles Show Details

Chen, Ming-Yi

Journal of Electronic Commerce Research, 2016 , vol. 17, # 2 p. 188 - 204 Title/Abstract Full Text View citing articles Show Details

Polyudin

Radiochemistry, 2016 , vol. 58, # 3 p. 329 - 332 Title/Abstract Full Text View citing articles Show Details

Al-Sabahi, Jamal Nasser; Hanif, Muhammad Asif; Al-Maskari, Ahmed Yahya; Al Busaidi, Muna Said Mohamed; Al-Maskari, Masoud Yahya; Al-Haddabi, Mansour Hamed

Journal of Essential Oil-Bearing Plants, 2016 , vol. 19, # 3 p. 719 - 726 Title/Abstract Full Text View citing articles Show Details

Mercurio, Isabella; Troiano, Gianmarco; Melai, Paola; Simone, Rosaria; Nante, Nicola; Bacci, Mauro

Epidemiology Biostatistics and Public Health, 2016 , vol. 13, # 2 art. no. E11732, p. 7 Title/Abstract Full Text View citing articles Show Details

Zubarevich

Regional Research of Russia, 2016 , vol. 6, # 2 p. 95 - 104

Title/Abstract Full Text View citing articles Show Details

Dave, Rutwij A.; Morris, Marilyn E.

International Journal of Pharmaceutics, 2016 , vol. 511, # 1 p. 111 - 126 Title/Abstract Full Text View citing articles Show Details

Bowman-Bowen, Lisa C.; Menard, Scott

Journal of Drug Issues, 2016 , vol. 46, # 3 p. 178 - 197 Title/Abstract Full Text View citing articles Show Details

Carter, R. Colin; Jacobson, Joseph L.; Molteno, Christopher D.; Dodge, Neil C.; Meintjes, Ernesta M.; Jacobson, Sandra W.

Pediatrics, 2016 , vol. 138, # 2 art. no. E20160775 Title/Abstract Full Text View citing articles Show Details

Robertson, Frances C.; Narr, Katherine L.; Molteno, Christopher D.; Jacobson, Joseph L.; Jacobson, Sandra W.; Meintjes, Ernesta M.

Cerebral Cortex, 2016 , vol. 26, # 7 p. 3083 - 3095 Title/Abstract Full Text View citing articles Show Details

Deepakumari, Hemavathi N.; Jayanna, Bidarur K.; Prashanth, Maralekere K.; Revanasiddappa, Hosakere D.; Veeresh, Bantal

Archiv der Pharmazie, 2016 , p. 566 - 571 Title/Abstract Full Text View citing articles Show Details

Sommer, Jessica; Hinsberger, Martina; Elbert, Thomas; Holtzhausen, Leon; Kaminer, Debra; Seedat, Soraya; Madikane, Solomon; Weierstall, Roland

Addictive Behaviors, 2017 , vol. 64, p. 29 - 34 Title/Abstract Full Text View citing articles Show Details

Harker Burnhams, Nadine; Laubscher, Ria; Howell, Simon; Shaw, Mark; Erasmus, Jodilee; Townsend, Loraine

Substance Abuse: Treatment, Prevention, and Policy, 2016 , vol. 11, # 1 art. no. 31 Title/Abstract Full Text Show Details

Mowry, James B.; Spyker, Daniel A.; Cantilena, Louis R.; McMillan, Naya; Ford, Marsha

Clinical Toxicology, 2014 , vol. 52, # 10 p. 1032 - 1283 Title/Abstract Full Text Show Details

Okrouhlá, Monika; Stupka, Roman; Čítek, Jaroslav; Urbanová, Daniela; Vehovský, Karel; Kouřimská, Lenka

Chemicke Listy, 2016 , vol. 110, # 8 p. 593 - 597 Title/Abstract Full Text Show Details

Kumar, Rajeev; Sirohi; Singh, Hariram; Yadav, Ramji; Roy; Chaudhary; Pandeya

Mini-Reviews in Medicinal Chemistry, 2014 , vol. 14, # 2 p. 168 - 207 Title/Abstract Full Text Show Details

Cernei, Natalia; Lackova, Zuzana; Guran, Roman; Hynek, David; Skladanka, Jiri; Horky, Pavel; Zitka, Ondrej; Adam, Vojtech

International Journal of Environmental Research and Public Health, 2016 , vol. 13, # 9 art. no. 904 Title/Abstract Full Text Show Details

Ajani, Olayinka Oyewale; Aderohunmu, Damilola Victoria; Umeokoro, Ejike Nzube; Olomieja, Ayodele Ojo

Bangladesh Journal of Pharmacology, 2016 , vol. 11, # 3 p. 716 - 733 Title/Abstract Full Text Show Details

10 of 60

Comment (Pharmacological Data)

Bioactivities present

Reference

Liebenberg; du Toit-Prinsloo; Steenkamp; Saayman

South African Medical Journal, 2016 , vol. 106, # 10 p. 1051 - 1055 Title/Abstract Full Text Show Details

Corcoran, Peter

IEEE Potentials, 2016 , vol. 35, # 5 art. no. 7563505, p. 30 - 35 Title/Abstract Full Text Show Details

Zhai, Zhiqiang (John); Johnson, Mary-Hall; Mankibi, Mohamed El; Stathopoulos, Nikolaos

International Journal of Ventilation, 2016 , vol. 15, # 3-4 p. 186 - 204 Title/Abstract Full Text Show Details

Lan, Wei; Wang, Jianxin; Li, Min; Liu, Jin; Li, Yaohang; Wu, Fang-Xiang; Pan, Yi

Neurocomputing, 2016 , vol. 206, p. 50 - 57 Title/Abstract Full Text Show Details

Bumbrah, Gurvinder Singh; Sharma, Rakesh Mohan

Egyptian Journal of Forensic Sciences, 2016 , vol. 6, # 3 p. 209 - 215 Title/Abstract Full Text Show Details

Vidlářová, Lucie; Hanuš, Jaroslav; Veselý, Martin; Ulbrich, Pavel; Štěpánek, František; Zbytovská, Jarmila

European Journal of Pharmaceutics and Biopharmaceutics, 2016 , vol. 108, p. 289 - 296 Title/Abstract Full Text Show Details

Heimes, Rita

IEEE Security and Privacy, 2016 , vol. 14, # 5 art. no. 7676168, p. 68 - 72 Title/Abstract Full Text Show Details

Solinas-Saunders, Monica; Stacer, Melissa J.

Victims and Offenders, 2017 , vol. 12, # 1 p. 138 - 173 Title/Abstract Full Text Show Details

Pittermannová; Ruberová; Zadražil; Bremond; Bibette; Štěpánek

RSC Advances, 2016 , vol. 6, # 105 p. 103532 - 103540 Title/Abstract Full Text Show Details

Shoemaker, Michael J.; Roper, Sarah E.; Calkins, Tonya N.

Heart International, 2016 , vol. 11, # 1 p. e25 - e31 Title/Abstract Full Text Show Details

Wisniewski, Julia A.; McLaughlin, Anne P.; Stenger, Philip J.; Patrie, James; Brown, Mark A.; El-Dahr, Jane M.; Platts-Mills, Thomas A.E.; Byrd, Nora J.; Heymann, Peter W.

Allergy and Asthma Proceedings, 2016 , vol. 37, # 6 p. 475 - 481 Title/Abstract Full Text Show Details

Bluth, Martin H.; Pincus, Matthew R.

Clinics in Laboratory Medicine, 2016 , vol. 36, # 4 p. 603 - 634 Title/Abstract Full Text Show Details

Harris, Benjamin H L; Wilson, David J

Medical Education, 2016 , vol. 50, # 12 p. 1227 - 1228 Title/Abstract Full Text Show Details

Al-Eraky, Mohamed; Marei, Hesham

Medical Education, 2016 , vol. 50, # 12 p. 1253 - 1257

Title/Abstract Full Text Show Details

Patel, Misari; Kothari, Charmy

TrAC - Trends in Analytical Chemistry, 2017 , vol. 86, p. 206 - 221 Title/Abstract Full Text Show Details

Attali, Valérie; Chaumereuil, Charlotte; Arnulf, Isabelle; Golmard, Jean-Louis; Tordjman, Fabienne; Morin, Laurent; Goudot, Patrick; Similowski, Thomas; Collet, Jean-Marc

Sleep Medicine, 2016 , vol. 27-28, p. 107 - 114 Title/Abstract Full Text Show Details

Sileo, Katelyn M.; Simbayi, Leickness C.; Abrams, Amber; Cloete, Allanise; Kiene, Susan M.

Drug and Alcohol Dependence, 2016 , vol. 167, p. 103 - 111 Title/Abstract Full Text Show Details

Xu, Wei; Zhu, Xiao-Rui; Qian, Peng-Cheng; Zhang, Xing-Guo; Deng, Chen-Liang

Synlett, 2016 , vol. 27, # 20 art. no. ST-2016-W0432-L, p. 2851 - 2857 Title/Abstract Full Text Show Details

Dadeya, Subhash; Dangda, Sonal

Strabismus, 2016 , vol. 24, # 4 p. 146 - 152 Title/Abstract Full Text Show Details

Katselou, Maria; Papoutsis, Ioannis; Nikolaou, Panagiota; Spiliopoulou, Chara; Athanaselis, Sotiris

Biomedical Chromatography, 2017 , vol. 31, # 1 art. no. E3727 Title/Abstract Full Text Show Details

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13 of 60

Comment (Pharmacological Data)

Bioactivities present

Reference

Kominkova, Marketa; Milosavljevic, Vedran; Vitek, Petr; Polanska, Hana; Cihalova, Kristyna; Dostalova, Simona; Hynstova, Veronika; Guran, Roman; Kopel, Pavel; Richtera, Lukas; Masarik, Michal; Brtnicky, Martin; Kynicky, Jindrich; Zitka, Ondrej; Adam, Vojtech

Journal of Biotechnology, 2017 , vol. 241, p. 193 - 200 Title/Abstract Full Text Show Details

Lederer, Katharina; Fouche, Jean-Paul; Wilson, Don; Stein, Dan J.; Uhlmann, Anne

Metabolic Brain Disease, 2016 , vol. 31, # 1 p. 53 - 62 Title/Abstract Full Text Show Details

Carson, Mariah; Kerrigan, Sarah

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2017 , vol. 1040, p. 289 - 294 Title/Abstract Full Text Show Details

Warner, Laura A.; Chaudhary, Anil Kumar; Galindo-Gonzalez, Sebastian

HortTechnology, 2016 , vol. 26, # 6 p. 852 - 861 Title/Abstract Full Text Show Details

Vegesna, Ashok; Tran, Melody; Angelaccio, Michele; Arcona, Steve

Telemedicine and e-Health, 2017 , vol. 23, # 1 p. 3 - 17 Title/Abstract Full Text Show Details

Gong, Youhui; Diao, Qingyun

Ecotoxicology, 2017 , vol. 26, # 1 Title/Abstract Full Text Show Details

Chandrasekhar, Sneha; Pradhan, Suresh M.; Bhattacharya, Madhumita; Pradeep, Ratna; Datta, Debabrata

Nuclear Technology and Radiation Protection, 2016 , vol. 31, # 4 p. 388 - 392 Title/Abstract Full Text Show Details

Wadström, Jonas; Ericzon, Bo-Göran; Halloran, Philip F.; Bechstein, Wolf O.; Opelz, Gerhard; Serón, Daniel; Grinyó, Josep; Loupy, Alexandre; Kuypers, Dirk; Mariat, Christophe; Clancy, Marc; Jardine, Alan G.; Guirado, Lluís; Fellström, Bengt; O'Grady, John; Pirenne, Jacques; O'Leary, Jacqueline G.; Aluvihare, Varuna; Trunečka, Pavel; Baccarani, Umberto; Neuberger, James; Soto-Gutierrez, Alejandro; Geissler, Edward K.; Metzger, Monty; Gray, Muir

Transplantation, 2017 , vol. 101, # 2 p. S1 - S41 Title/Abstract Full Text Show Details

Kim, Yongseok; Min, Hophil; Sung, Changmin; Park, Ju-Hyung; Son, Junghyun; Lee, Kang Mi; Kim, Ho Jun; Lee, Jaeick; Kwon, Oh-Seung; Kim, Ki Hun

Mass Spectrometry Letters, 2016 , vol. 7, # 4 p. 111 - 115 Title/Abstract Full Text Show Details

Kong, Tae Yeon; Kim, Ju Hyun; Kim, Jin Young; In, Moon Kyo; Choi, Kyung Ho; Kim, Hee Seung; Lee, Hye Suk

Archives of Pharmacal Research, 2017 , vol. 40, # 2 p. 180 - 196 Title/Abstract Full Text Show Details

Zayed, Mohamed F.; Ihmaid, Saleh K.; Ahmed, Hany E.A.; El-Adl, Khaled; Asiri, Ahmed M.; Omar, Abdelsattar M.

Molecules, 2017 , vol. 22, # 2 art. no. 188 Title/Abstract Full Text Show Details

Moodie, Lindon W. K.; Trepos, Rozenn; Cervin, Gunnar; Larsen, Lesley; Larsen, David S.; Pavia, Henrik; Hellio, Claire; Cahill, Patrick; Svenson, Johan

Journal of Natural Products, 2017 , vol. 80, # 2 p. 515 - 525 Title/Abstract Full Text Show Details

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Patel, Harun M.; Noolvi, Malleshappa N.; Shirkhedkar, Atul A.; Kulkarni, Abhijeet D.; Pardeshi, Chandrakantsing V.; Surana, Sanjay J.

RSC Advances, 2016 , vol. 6, # 50 p. 44435 - 44455 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Deepakumari, Hemavathi N.; Jayanna, Bidarur K.; Prashanth, Maralekere K.; Revanasiddappa, Hosakere D.; Veeresh, Bantal

Archiv der Pharmazie, 2016 , p. 566 - 571 Title/Abstract Full Text View citing articles Show Details

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16 of 60

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Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Molecular Pharmacology, 2015 , vol. 88, # 2 p. 401 - 420 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Zayed, Mohamed F.; Ahmed, Hany E. A.; Omar, Abdel-Sattar M.; Abdelrahim, Adel S.; El-Adl, Khaled

Medicinal Chemistry Research, 2013 , vol. 22, # 12 p. 5823 - 5831 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Vanparia, Satish F.; Patel, Tarosh S.; Dixit, Ritu B.; Dixit, Bharat C.

Medicinal Chemistry Research, 2013 , vol. 22, # 11 p. 5184 - 5196 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

PTZ-induced convulsion; inhibition of

Species or TestSystem (Pharmacological Data)

Swiss albino mouse

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

200 mg/kg

Kind of Dosing (Pharmacological Data)

title comp. dissolved 10percent DMSO

Further Details (Pharmacological Data)

PTZ: pentylenetetrazol

Type (Pharmacological Data)

protection rate

Value of Type (Pharmacological Data)

100 percent

Reference

El-Azab, Adel S.; Eltahir, Kamal E.H.

Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 327 - 333 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

MES-induced seizure; inhibition of

Species or TestSystem (Pharmacological Data)

Swiss albino mouse

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

200 mg/kg

Kind of Dosing (Pharmacological Data)

title comp. dissolved 10percent DMSO

19 of 60

20 of 60

Further Details (Pharmacological Data)

MES: maximal electroshock test

Type (Pharmacological Data)

protection rate

Value of Type (Pharmacological Data)

100 percent

Reference

El-Azab, Adel S.; Eltahir, Kamal E.H.

Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 327 - 333 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

PTZ-induced convulsion; inhibition of

Species or TestSystem (Pharmacological Data)

Swiss albino mouse

Sex

male

Route of Application

intraperitoneal

Kind of Dosing (Pharmacological Data)

title comp. dissolved 10percent DMSO

Further Details (Pharmacological Data)

PTZ: pentylenetetrazol; effective dose (ED)

Type (Pharmacological Data)

ED50

Value of Type (Pharmacological Data)

200 mg/kg

Reference

El-Azab, Adel S.; Eltahir, Kamal E.H.

Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 327 - 333 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

neurotoxic

Species or TestSystem (Pharmacological Data)

Swiss albino mouse

Sex

male

Route of Application

intraperitoneal

Further Details (Pharmacological Data)

chimney test; toxic dose (TD)

Type (Pharmacological Data)

TD50

Value of Type (Pharmacological Data)

400 mg/kg

Reference

El-Azab, Adel S.; Eltahir, Kamal E.H.

Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 327 - 333 Title/Abstract Full Text View citing articles Show Details

Show next 20

21 of 60

Hide facts

Effect (Pharmacological Data)

toxic

Species or TestSystem

Swiss albino mouse

(Pharmacological Data)

22 of 60

23 of 60

24 of 60

Sex

male

Further Details (Pharmacological Data)

lethal dose (LD)

Type (Pharmacological Data)

LD50

Value of Type (Pharmacological Data)

500 mg/kg

Reference

El-Azab, Adel S.; Eltahir, Kamal E.H.

Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 327 - 333 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

MES-induced seizure; inhibition of

Species or TestSystem (Pharmacological Data)

mouse

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

1.4 mmol/kg

Further Details (Pharmacological Data)

MES: maximal electroshock

Type (Pharmacological Data)

protection rate

Value of Type (Pharmacological Data)

100 percent

Location

supporting information

Reference

El-Azab, Adel S.; Eltahir, Kamal E.H.

Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 5 p. 1879 - 1885 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

PTZ-induced seizure; inhibition of

Species or TestSystem (Pharmacological Data)

mouse

Route of Application

intraperitoneal

Further Details (Pharmacological Data)

PTZ: pentylenetetrazol; protection rate(sodium valproate): 100 percent at 1.5 mmol/kg at dose; protection rate(methaqualone): 100 percent at 1.4 mmol/kg dose

Type (Pharmacological Data)

ED50

Value of Type (Pharmacological Data)

1.4 mmol/kg

Location

supporting information

Reference

El-Azab, Adel S.; Eltahir, Kamal E.H.

Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 5 p. 1879 - 1885 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological

PTZ-induced seizure; inhibition of

Data)

25 of 60

26 of 60

27 of 60

Species or TestSystem (Pharmacological Data)

mouse

Route of Application

intraperitoneal

Further Details (Pharmacological Data)

PTZ: pentylenetetrazol; protection rate: 100 percent at 1.0 mmol/kg dose; protection rate(sodium valproate): 100 percent at 1.5 mmol/kg at dose; protection rate(methaqualone): 100 percent at 1.4 mmol/kg dose

Type (Pharmacological Data)

ED50

Value of Type (Pharmacological Data)

1.4 mmol/kg

Location

supporting information

Reference

El-Azab, Adel S.; Eltahir, Kamal E.H.

Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 5 p. 1879 - 1885 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

lethal

Species or TestSystem (Pharmacological Data)

mouse

Further Details (Pharmacological Data)

lethal dose (LD)

Type (Pharmacological Data)

LD50

Value of Type (Pharmacological Data)

2 mmol/kg

Location

supporting information

Reference

El-Azab, Adel S.; Eltahir, Kamal E.H.

Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 5 p. 1879 - 1885 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

neurotoxic

Species or TestSystem (Pharmacological Data)

mouse

Route of Application

intraperitoneal

Further Details (Pharmacological Data)

chimney test; toxic dose (TD)

Type (Pharmacological Data)

TD50

Value of Type (Pharmacological Data)

1.6 mmol/kg

Location

supporting information

Reference

El-Azab, Adel S.; Eltahir, Kamal E.H.

Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 5 p. 1879 - 1885 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological

picrotoxin-induced seizure; inhibition of

Data)

28 of 60

29 of 60

Species or TestSystem (Pharmacological Data)

mouse

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

1.4 mmol/kg

Type (Pharmacological Data)

protection rate

Value of Type (Pharmacological Data)

50 percent

Location

supporting information

Reference

El-Azab, Adel S.; Eltahir, Kamal E.H.

Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 5 p. 1879 - 1885 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

lethal

Species or TestSystem (Pharmacological Data)

white Swiss albino mouse

Sex

male

Further Details (Pharmacological Data)

mass of species: 20 - 25 g; lethal dose (LD)

Type (Pharmacological Data)

LD50

Value of Type (Pharmacological Data)

2 mmol/kg

Reference

El-Azab, Adel S.; ElTahir, Kamal E. H.

Medicinal Chemistry Research, 2012 , vol. 21, # 11 p. 3785 - 3796 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

maximal electroshock-induced seizures; prevention of

Species or TestSystem (Pharmacological Data)

white Swiss albino mouse

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

0.5 mmol/kg

Further Details (Pharmacological Data)

mass of species: 20 - 25 g

Type (Pharmacological Data)

protection rate

Value of Type (Pharmacological Data)

100 percent

Reference

El-Azab, Adel S.; ElTahir, Kamal E. H.

Medicinal Chemistry Research, 2012 , vol. 21, # 11 p. 3785 - 3796 Title/Abstract Full Text View citing articles Show Details

30 of 60

31 of 60

32 of 60

Effect (Pharmacological Data)

neurotoxic

Species or TestSystem (Pharmacological Data)

white Swiss albino mouse

Sex

male

Method (Pharmacological Data)

name of assay/method: chimney test

Further Details (Pharmacological Data)

mass of species: 20 - 25 g; toxic dose (TD)

Type (Pharmacological Data)

TD50

Value of Type (Pharmacological Data)

1.6 mmol/kg

Reference

El-Azab, Adel S.; ElTahir, Kamal E. H.

Medicinal Chemistry Research, 2012 , vol. 21, # 11 p. 3785 - 3796 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

phenylenetetrazole-induced seizure

Species or TestSystem (Pharmacological Data)

white Swiss albino mouse

Sex

male

Route of Application

intraperitoneal

Further Details (Pharmacological Data)

mass of species: 20 - 25 g; effective dose (ED)

Type (Pharmacological Data)

ED50

Value of Type (Pharmacological Data)

1.4 mmol/kg

Reference

El-Azab, Adel S.; ElTahir, Kamal E. H.

Medicinal Chemistry Research, 2012 , vol. 21, # 11 p. 3785 - 3796 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

phenylenetetrazole-induced seizure; prevention of

Species or TestSystem (Pharmacological Data)

white Swiss albino mouse

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

1.5 mmol/kg

Further Details (Pharmacological Data)

mass of species: 20 - 25 g

Type (Pharmacological Data)

protection rate

100 percent

Value of Type (Pharmacological Data)

33 of 60

34 of 60

35 of 60

Reference

El-Azab, Adel S.; ElTahir, Kamal E. H.

Medicinal Chemistry Research, 2012 , vol. 21, # 11 p. 3785 - 3796 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

MES-induced seizure; protection of

Species or TestSystem (Pharmacological Data)

Swiss albino mouse

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

1.4 mmol/kg

Further Details (Pharmacological Data)

maximal electroshock (MES) model

Type (Pharmacological Data)

protection rate

Value of Type (Pharmacological Data)

100 percent

Reference

El-Azab, Adel S.; ElTahir, Kamal E.H.; Attia, Sabry M.

Monatshefte fur Chemie, 2011 , vol. 142, # 8 p. 837 - 848 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

PTZ-induced seizure; protection of

Species or TestSystem (Pharmacological Data)

Swiss albino mouse

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

1.4 mmol/kg

Further Details (Pharmacological Data)

pentylentetrazole (PTZ) model

Type (Pharmacological Data)

protection rate

Value of Type (Pharmacological Data)

100 percent

Reference

El-Azab, Adel S.; ElTahir, Kamal E.H.; Attia, Sabry M.

Monatshefte fur Chemie, 2011 , vol. 142, # 8 p. 837 - 848 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

PTZ-induced seizure; protection of

Species or TestSystem (Pharmacological Data)

Swiss albino mouse

Sex

male intraperitoneal

Route of Application

36 of 60

37 of 60

38 of 60

Concentration (Pharmacological Data)

1.4 mmol/kg

Further Details (Pharmacological Data)

pentylentetrazole (PTZ) model; ED50: median effective dose providing anticonvulsant protection in 50percent of mice against PTZ-induced seizures

Type (Pharmacological Data)

protection rate

Value of Type (Pharmacological Data)

100 percent

Reference

El-Azab, Adel S.; ElTahir, Kamal E.H.; Attia, Sabry M.

Monatshefte fur Chemie, 2011 , vol. 142, # 8 p. 837 - 848 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

PTZ-induced seizure; protection of

Species or TestSystem (Pharmacological Data)

Swiss albino mouse

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

1.4 mmol/kg

Further Details (Pharmacological Data)

pentylentetrazole (PTZ) model; ED50: median effective dose providing anticonvulsant protection in 50percent of mice against PTZ-induced seizures; effective dose (ED)

Type (Pharmacological Data)

ED50

Value of Type (Pharmacological Data)

1.4 mmol/kg

Reference

El-Azab, Adel S.; ElTahir, Kamal E.H.; Attia, Sabry M.

Monatshefte fur Chemie, 2011 , vol. 142, # 8 p. 837 - 848 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

neurotoxic

Species or TestSystem (Pharmacological Data)

Swiss albino mouse

Sex

male

Route of Application

intraperitoneal

Further Details (Pharmacological Data)

chimney test; TD50: median toxic dose producing minimal neurological toxicity in 50percent of mice subjected to the chimney test; toxic dose (TD)

Type (Pharmacological Data)

TD50

Value of Type (Pharmacological Data)

1.6 mmol/kg

Reference

El-Azab, Adel S.; ElTahir, Kamal E.H.; Attia, Sabry M.

Monatshefte fur Chemie, 2011 , vol. 142, # 8 p. 837 - 848 Title/Abstract Full Text View citing articles Show Details

picrotoxin-induced seizure; protection of

Effect (Pharmacological Data)

39 of 60

40 of 60

Species or TestSystem (Pharmacological Data)

Swiss albino mouse

Sex

male

Route of Application

intraperitoneal

Concentration (Pharmacological Data)

1.4 mmol/kg

Further Details (Pharmacological Data)

picrotoxin model

Type (Pharmacological Data)

protection rate

Value of Type (Pharmacological Data)

50 percent

Reference

El-Azab, Adel S.; ElTahir, Kamal E.H.; Attia, Sabry M.

Monatshefte fur Chemie, 2011 , vol. 142, # 8 p. 837 - 848 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

toxic

Species or TestSystem (Pharmacological Data)

Swiss albino mouse

Sex

male

Route of Application

intraperitoneal

Further Details (Pharmacological Data)

LD50 : median lethal dose that causes 50percent mortality in mice; lethal dose (LD)

Type (Pharmacological Data)

LD50

Value of Type (Pharmacological Data)

11.9 mmol/kg

Reference

El-Azab, Adel S.; ElTahir, Kamal E.H.; Attia, Sabry M.

Monatshefte fur Chemie, 2011 , vol. 142, # 8 p. 837 - 848 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

enzyme; inhib. of

Species or TestSystem (Pharmacological Data)

human liver cytosol

Concentration (Pharmacological Data)

50 μmol/l

Kind of Dosing (Pharmacological Data)

DMSO stock; final solvent conc. 1 percent (v/v)

Method (Pharmacological Data)

aldehyde oxidase study; phthalazine (2 μmol/l) preincubated with title comp. at 37 deg C; reaction mixture containing cytosol, EDTA and potassium phosphate buffer (pH 7.4) added; 2.5 min incubation; 1-phthalazinone in filtrate analysed by HPLC-MS

Further Details (Pharmacological Data)

EDTA: ethylenediaminetetraacetic acid

41 of 60

42 of 60

43 of 60

Results

enzyme activity was inhibited to 68 percent

Reference

Obach, R. Scott; Huynh, Phuong; Allen, Mary C.; Beedham, Christine

Journal of Clinical Pharmacology, 2004 , vol. 44, # 1 p. 7 - 19 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

behavioural symptoms

Species or TestSystem (Pharmacological Data)

Papio anubis LE baboon

Sex

male

Route of Application

peroral

Concentration (Pharmacological Data)

1 - 56 mg/kg

Kind of Dosing (Pharmacological Data)

title comp. blended for 3 min into a volume of 60 ml of a matrix prepared with 1-2 g/l of BIO-Serv Agent K in distilled water flavored with orange-drink powder (52 g/l)

Method (Pharmacological Data)

baboon trained to discriminate lorazepam (1.8 mg/kg, p.o.); treated with title comp. or vehicle (quinine SO4); post 60 min lever responses counted; generalization and drug-discrimination performance determined

Further Details (Pharmacological Data)

control: without title comp.; generalization: peak mean percentage of lorazepam-lever responding by 80 percent or more

Results

title comp. at 10 mg/kg occasioned 92 percent of lorazepam-lever responding; diagram

Reference

Ator, Nancy A.; Griffiths, Roland R.

Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 282, # 3 p. 1442 - 1457 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

behavioural symptoms

Species or TestSystem (Pharmacological Data)

Papio cynocephalus LO baboon

Sex

male

Route of Application

peroral

Concentration (Pharmacological Data)

1 - 56 mg/kg

Kind of Dosing (Pharmacological Data)

title comp. blended for 3 min into a volume of 60 ml of a matrix prepared with 1-2 g/l of BIO-Serv Agent K in distilled water flavored with orange-drink powder (52 g/l)

Method (Pharmacological Data)

Further Details (Pharmacological Data)

control: without title comp.; generalization: peak mean percentage of lorazepam-lever responding by 80 percent or more

Comment (Pharmacological Data)

No effect

Reference

Ator, Nancy A.; Griffiths, Roland R.

Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 282, # 3 p. 1442 - 1457 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

behavioural symptoms

Species or TestSystem (Pharmacological

Papio anubis ML baboon

Data)

44 of 60

45 of 60

Sex

male

Route of Application

peroral

Concentration (Pharmacological Data)

1 - 56 mg/kg

Kind of Dosing (Pharmacological Data)

title comp. blended for 3 min into a volume of 60 ml of a matrix prepared with 1-2 g/l of BIO-Serv Agent K in distilled water flavored with orange-drink powder (52 g/l)

Method (Pharmacological Data)

Further Details (Pharmacological Data)

control: without title comp.; generalization: peak mean percentage of lorazepam-lever responding by 80 percent or more

Comment (Pharmacological Data)

No effect

Reference

Ator, Nancy A.; Griffiths, Roland R.

Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 282, # 3 p. 1442 - 1457 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

behavioural symptoms

Species or TestSystem (Pharmacological Data)

Papio anubis MS baboon

Sex

male

Route of Application

peroral

Concentration (Pharmacological Data)

1 - 56 mg/kg

Kind of Dosing (Pharmacological Data)

title comp. blended for 3 min into a volume of 60 ml of a matrix prepared with 1-2 g/l of BIO-Serv Agent K in distilled water flavored with orange-drink powder (52 g/l)

Method (Pharmacological Data)

Further Details (Pharmacological Data)

control: without title comp.; generalization: peak mean percentage of lorazepam-lever responding by 80 percent or more

Comment (Pharmacological Data)

No effect

Reference

Ator, Nancy A.; Griffiths, Roland R.

Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 282, # 3 p. 1442 - 1457 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

behavioural symptoms

Species or TestSystem (Pharmacological Data)

Papio anubis RA baboon

Sex

male

Route of Application

peroral

Concentration (Pharmacological Data)

1 - 56 mg/kg

Kind of Dosing

title comp. blended for 3 min into a volume of 60 ml of a matrix prepared with 1-2 g/l of BIO-Serv Agent K in distilled water flavored with orange-drink powder (52 g/l)

(Pharmacological Data)

46 of 60

47 of 60

48 of 60

49 of 60

50 of 60

Method (Pharmacological Data)

Further Details (Pharmacological Data)

control: without title comp.; generalization: peak mean percentage of lorazepam-lever responding by 80 percent or more

Comment (Pharmacological Data)

No effect

Reference

Ator, Nancy A.; Griffiths, Roland R.

Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 282, # 3 p. 1442 - 1457 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

behavioural symptoms

Species or TestSystem (Pharmacological Data)

Papio anubis RF baboon

Sex

male

Route of Application

peroral

Concentration (Pharmacological Data)

1 - 56 mg/kg

Kind of Dosing (Pharmacological Data)

title comp. blended for 3 min into a volume of 60 ml of a matrix prepared with 1-2 g/l of BIO-Serv Agent K in distilled water flavored with orange-drink powder (52 g/l)

Method (Pharmacological Data)

Further Details (Pharmacological Data)

control: without title comp.; generalization: peak mean percentage of lorazepam-lever responding by 80 percent or more

Comment (Pharmacological Data)

No effect

Reference

Ator, Nancy A.; Griffiths, Roland R.

Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 282, # 3 p. 1442 - 1457 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

acute tocicity (LD50 400 mg/kg) in mice

Reference

Buyuktimkin; Ekinci; Otuk

Journal of Pharmaceutical Sciences, 1992 , vol. 81, # 11 p. 1092 - 1094 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

anticonvulsant (ED50 = 24.9 mg/kg) and spontaneous locomotor (TD50 = 59 mg/kg) activity in mice

Reference

Buyuktimkin; Ekinci; Otuk

Journal of Pharmaceutical Sciences, 1992 , vol. 81, # 11 p. 1092 - 1094 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

LD50(rats) = 565 mg/kg, ip

Reference

Houlihan, William J.; Gogerty, John H.; Ryan, Eileen A.; Schmitt, Gemma

Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 28 - 31 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

active as sleep-inducer (monkey)

Reference

Houlihan, William J.; Gogerty, John H.; Ryan, Eileen A.; Schmitt, Gemma

Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 28 - 31 Title/Abstract Full Text View citing articles Show Details

51 of 60

52 of 60

53 of 60

54 of 60

55 of 60

56 of 60

57 of 60

58 of 60

59 of 60

60 of 60

Comment (Pharmacological Data)

central nervous system depressant (mice); behavior ED50(mg/kg ip): ataxia 34.4, docility 35.6, LRR 39.8; anticonvulsant activity (antagonism to N-SA) ED50 = 31.5 mg/kg ip; rotarod ND50 = 31.5 mg/kg ip; barbiturate reinduction RD50 = 21.9 mg/kg ip

Reference

Houlihan, William J.; Gogerty, John H.; Ryan, Eileen A.; Schmitt, Gemma

Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 28 - 31 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

activity in minimal metrazol seizure threshold to persistent clonus and maximal metrazol threshold to tonic flexion tests (mice)

Reference

Fatmi, Aqeel A.; Vaidya, Niteen A.; Iturrian, W. B.; Blanton, C. DeWitt

Journal of Medicinal Chemistry, 1984 , vol. 27, # 6 p. 772 - 778 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

anticonvulsant activity in the maximal electroshock (MES) seizure test and activity in the pentylenetetrazol (sc Met) seizure threshold test (ED50 = 33.5 mg/kg) in mice; activity in the acute neurotoxicity with rotorod test (TD50 = 55 mg/kg) in mice

Reference

Fatmi, Aqeel A.; Vaidya, Niteen A.; Iturrian, W. B.; Blanton, C. DeWitt

Journal of Medicinal Chemistry, 1984 , vol. 27, # 6 p. 772 - 778 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

neurotoxic dose: TD50=55 mg/kg (mice; ip)

Reference

Vaidya; Panos; Kite; Iturrian; Blanton Jr.

Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1422 - 1425 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

anticonvulsant activity (mice; ip): maximal electroshock (MES): ED50=52 mg/kg; pentylenetetrazol test (sc Met): ED50=33.5 mg/kg

Reference

Vaidya; Panos; Kite; Iturrian; Blanton Jr.

Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1422 - 1425 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

pharmacokinetics modification by concomitant or chronic intraperitoneal administration of diphenhydramine in rats

Reference

Gupta; Bhargava; Ali

Journal of Pharmacy and Pharmacology, 1982 , vol. 34, # 11 p. 744 - 746 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

Hypnotic effect

Reference

Hisano; Ichikawa; Nakagawa; Tsuji

Chemical and Pharmaceutical Bulletin, 1975 , vol. 23, # 9 p. 1910 - 1916 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

extrem bitterer Geschmack

Reference

Schnellbach; Houta

Pharmaceutica Acta Helvetiae, 1972 , vol. 47, p. 75,76,78-82 Full Text Show Details

Comment (Pharmacological Data)

Tab.II

Reference

Hardtmann et al.

Journal of Medicinal Chemistry, 1971 , vol. 14, p. 878,881 Full Text Show Details

Comment (Pharmacological Data)

Nach Verabfolgung an Kaninchen enthaelt deren Harn nach Behdl. mit β-Glucuronidase 2-Methyl-3-<2-hydroxymethyl-phenyl>-4(3H)chinazolinon

Reference

AKAGI; OKETANI; YAMANE

Chemical and pharmaceutical bulletin, 1963 , vol. 11, p. 1216 - 1217

Title/Abstract Full Text View citing articles Show Details

Other Data Use (4) Use Pattern

Reference

Sedative

PFIZER LIMITED

Patent: WO2008/135830 A1, 2008 ; Title/Abstract Full Text Show Details

Bristol, David William; King, Clifford Riley; Mitchener, JR., Joseph Pike; Audia, Vicki Haynes

Patent: US2008/293695 A1, 2008 ;

Anti-abuse

Title/Abstract Full Text Show Details

Renshaw, Perry F.; Cohen, Bruce M.

Patent: US2006/39890 A1, 2006 ;

depressant

Title/Abstract Full Text Show Details

sedative or hypnotic agent

Aventis Pharmaceuticals, Inc.

Patent: US6984620 B1, 2006 ; Title/Abstract Full Text Show Details

Chemical Name: (+)-methaqualone

Reaxys Registry Number: 5747457

CAS Registry Number: 72-44-6, 81718-89-0, 81882-39-5, 93240-42-7 Type of Substance: heterocyclic Molecular Formula: C16H14N2O Linear Structure Formula: C16H14N2O Molecular Weight: 250.3

InChI Key: JEYCTXHKTXCGPB-UHFFFAOYSA-N

5 prep out of 6 reactions.

Identification Physical Data (2) Spectra (2)

Synthesize | Hide Details Find similar Chemical Names and Synonyms (+)-methaqualone, methaqualone Identification Substance Label (2) Label

Reference

Hirai, Motohiro; Terada, Shumpei; Yoshida, Hiroaki; Ebine, Kenki; Hirata, Tomoaki; Kitagawa, Osamu

Organic Letters, 2016 , vol. 18, # 21 p. 5700 - 5703 Title/Abstract Full Text Show Details

(+)-1

Mannschreck; Koller; Stuhler; et al.

European Journal of Medicinal Chemistry, 1984 , vol. 19, # 4 p. 381 - 383 Title/Abstract Full Text View citing articles Show Details

Purification (1) Purification (method)

Reference

separation of the enantomers by HPLC on triacetylcellulose

Mannschreck; Koller; Stuhler; et al.

European Journal of Medicinal Chemistry, 1984 , vol. 19, # 4 p. 381 - 383 Title/Abstract Full Text View citing articles Show Details

Physical Data

Chromatographic Data (1) Chromatographic data

Location

Reference

HPLC (High performance liquid chromatography)

supporting information

Hirai, Motohiro; Terada, Shumpei; Yoshida, Hiroaki; Ebine, Kenki; Hirata, Tomoaki; Kitagawa, Osamu

Organic Letters, 2016 , vol. 18, # 21 p. 5700 - 5703 Title/Abstract Full Text Show Details

Optical Rotatory Power (1) Type (Optical Rotatory Power)

Concentration (Optical Rotatory Power)

Enantiomeric excess

Solvent (Optical Rotatory Power)

Optical Rotatory Power

Wavelength (Optical Rotatory Power)

[alpha]

0.17 g/100ml

42 %ee

chloroform

31.8 deg

589 nm

Location

Reference

supporting information

Hirai, Motohiro; Terada, Shumpei; Yoshida, Hiroaki; Ebine, Kenki; Hirata, Tomoaki; Kitagawa, Osamu

Organic Letters, 2016 , vol. 18, # 21 p. 5700 5703 Title/Abstract Full Text Show Details

Spectra NMR Spectroscopy (2) Description (NMR Spectroscopy)

Nucleus (NMR Spectroscopy)

Solvents (NMR Spectroscopy)

Temperature (NMR Spectroscopy)

Frequency (NMR Spectroscopy)

Chemical shifts Spectrum

chloroform-d1

21.8 °C

Chemical shifts Spectrum

13C

chloroform-d1

22.7 °C

Location

Reference

400 MHz

supporting information

Hirai, Motohiro; Terada, Shumpei; Yoshida, Hiroaki; Ebine, Kenki; Hirata, Tomoaki; Kitagawa, Osamu

Organic Letters, 2016 , vol. 18, # 21 p. 5700 - 5703 Title/Abstract Full Text Show Details

100 MHz

supporting information

Hirai, Motohiro; Terada, Shumpei; Yoshida, Hiroaki; Ebine, Kenki; Hirata, Tomoaki; Kitagawa, Osamu

Organic Letters, 2016 , vol. 18, # 21 p. 5700 - 5703 Title/Abstract Full Text Show Details

Chemical Name: (-)-methaqualone

Reaxys Registry Number: 5747458

CAS Registry Number: 72-44-6, 81718-89-0, 81882-39-5, 93240-42-7 Type of Substance: heterocyclic Molecular Formula: C16H14N2O Linear Structure Formula: C16H14N2O Molecular Weight: 250.3

InChI Key: JEYCTXHKTXCGPB-UHFFFAOYSA-N

6 prep out of 6 reactions.

Synthesize | Hide Details Find similar Chemical Names and Synonyms (-)-methaqualone, methaqualone Identification Substance Label (2) Label

Reference

Hirai, Motohiro; Terada, Shumpei; Yoshida, Hiroaki; Ebine, Kenki; Hirata, Tomoaki; Kitagawa, Osamu

Organic Letters, 2016 , vol. 18, # 21 p. 5700 - 5703 Title/Abstract Full Text Show Details

(-)-1

Mannschreck; Koller; Stuhler; et al.

European Journal of Medicinal Chemistry, 1984 , vol. 19, # 4 p. 381 - 383 Title/Abstract Full Text View citing articles Show Details

Identification Physical Data (1) Spectra (2)

Purification (1) Purification (method)

Reference

separation of the enantomers by HPLC on triacetylcellulose

Mannschreck; Koller; Stuhler; et al.

European Journal of Medicinal Chemistry, 1984 , vol. 19, # 4 p. 381 - 383 Title/Abstract Full Text View citing articles Show Details

Physical Data Chromatographic Data (1) Chromatographic data

Location

Reference

HPLC (High performance liquid chromatography)

supporting information

Hirai, Motohiro; Terada, Shumpei; Yoshida, Hiroaki; Ebine, Kenki; Hirata, Tomoaki; Kitagawa, Osamu

Organic Letters, 2016 , vol. 18, # 21 p. 5700 - 5703 Title/Abstract Full Text Show Details

Spectra NMR Spectroscopy (2) Description (NMR Spectroscopy)

Nucleus (NMR Spectroscopy)

Solvents (NMR Spectroscopy)

Temperature (NMR Spectroscopy)

Frequency (NMR Spectroscopy)

Chemical shifts Spectrum

chloroform-d1

21.8 °C

Chemical shifts Spectrum

13C

chloroform-d1

22.7 °C

Location

Reference

400 MHz

supporting information

Hirai, Motohiro; Terada, Shumpei; Yoshida, Hiroaki; Ebine, Kenki; Hirata, Tomoaki; Kitagawa, Osamu

Organic Letters, 2016 , vol. 18, # 21 p. 5700 - 5703 Title/Abstract Full Text Show Details

100 MHz

supporting information

Hirai, Motohiro; Terada, Shumpei; Yoshida, Hiroaki; Ebine, Kenki; Hirata, Tomoaki; Kitagawa, Osamu

Organic Letters, 2016 , vol. 18, # 21 p. 5700 - 5703 Title/Abstract Full Text Show Details

Chemical Name: 3-o-tolyl-2-trideuteriomethyl-3H-quinazolin-4-one

Reaxys Registry Number: 820010

Type of Substance: heterocyclic Molecular Formula: C16H14N2O Linear Structure Formula: C16H11D3N2O Molecular Weight: 253.276

InChI Key: JEYCTXHKTXCGPB-BMSJAHLVSA-N

Synthesize | Hide Details Find similar Chemical Names and Synonyms 3-o-tolyl-2-trideuteriomethyl-3H-quinazolin-4-one Identification Substance Label (1) Label

Reference

2-C%2&H3-MTQ

Bogentoft; Ericsson; Danielsson

Acta Pharmaceutica Suecica, 1974 , vol. 11, # 6 p. 513 - 522 Title/Abstract Full Text View citing articles Show Details

Spectra

1 prep out of 1 reactions.

Identification Spectra (1)

Mass Spectrometry (1) Reference Bogentoft; Ericsson; Danielsson

Acta Pharmaceutica Suecica, 1974 , vol. 11, # 6 p. 513 - 522 Title/Abstract Full Text View citing articles Show Details

Chemical Name: Methaqualone hydrochloride

no reactions.

Reaxys Registry Number: 3734596

CAS Registry Number: 340-56-7 Type of Substance: heterocyclic Molecular Formula: C16H14N2O*ClH Linear Structure Formula: C16H14N2O*ClH Molecular Weight: 286.761

InChI Key: KJUHIXIWKSVBKB-UHFFFAOYSA-N

Synthesize | Hide Details Find similar Chemical Names and Synonyms Methaqualone hydrochloride, Hyminal monohydrochloride, 2-methyl-3-o-tolyl-3H-quinazolin-4-one; hydrochloride, 2-Methyl-3-o-tolyl-3H-chinazolin-4on; Hydrochlorid, methaqualone hydrochloride, Somnium Physical Data Melting Point (1) Melting Point

Reference

248 - 250 °C

Kacker; Zaheer

Journal of the Indian Chemical Society, 1951 , vol. 28, p. 344 Full Text Show Details

Bioactivity Pharmacological Data (2) 1 of 2

2 of 2

Comment (Pharmacological Data)

Bioactivities present

Reference

Kacker; Zaheer

Journal of the Indian Chemical Society, 1951 , vol. 28, p. 344 Full Text Show Details

Hindmarsh; Wallace; Schneider; Korchinski

Journal of Pharmaceutical Sciences, 1983 , vol. 72, # 2 p. 176 - 180 Title/Abstract Full Text View citing articles Show Details

Borbe; Mueller; Wollert

Brain Research, 1980 , vol. 182, # 2 p. 466 - 469 Title/Abstract Full Text Show Details

Type: Review, Lab: EFF_071212, Owner: EFFECT, Number: 000, Revision: 07.12.2012 00:00:00 2012 Full Text Show Details

Otranto, Rosa

Aegyptus, 2012 , # 1 p. 157 - 172 Title/Abstract Full Text View citing articles Show Details

Miller, Richard S.; Lawrence, David J.

Astrophysical Journal Letters, 2016 , vol. 823, # 2 art. no. L31 Title/Abstract Full Text View citing articles Show Details

Orbán, Áron

Acta Antiqua Academiae Scientiarum Hungaricae, 2014 , vol. 54, # 2-3 p. 215 - 234 Title/Abstract Full Text Show Details

Bíró, Csilla

Acta Antiqua Academiae Scientiarum Hungaricae, 2014 , vol. 54, # 2-3 p. 309 - 318 Title/Abstract Full Text Show Details

Comment (Pharmacological Data)

pharmacokinetics in humans, effect of diphenhydramine additions

Reference

Hindmarsh; Wallace; Schneider; Korchinski

Physical Data (1) Bioactivity (2)

Journal of Pharmaceutical Sciences, 1983 , vol. 72, # 2 p. 176 - 180 Title/Abstract Full Text View citing articles Show Details

Chemical Name: mandrax Reaxys Registry Number: 29694141

Molecular Formula: C16H14N2O*C17H21NO*ClH Linear Structure Formula: C16H14N2O*C17H21NO*ClH Molecular Weight: 542.121

InChI Key: WDGXQSVUSMTYNG-UHFFFAOYSA-N 6

Synthesize | Hide Details Find similar Chemical Names and Synonyms mandrax

no reactions.