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ASPET 25 Year Members

ASPET thanks the following members who have devoted 25 years of service to ASPET and their commitment to the growth of our discipline.

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Nathan M. Appel, PhD William T. Beck, PhD Michael P. Blanton, PhD John N. Buchholz, PhD Lisa A. Cassis, PhD Thomas K. Chang, PhD Olivier Civelli, PhD Susan P. Cole, PhD Nissar A. Darmani, PhD Daryl L. Davies, PhD Martha I. Davila-Garcia, PhD Xinxin Ding, PhD Stephen W. Edwards, PhD Ayman O. El-Kadi, PhD Tim A. Esbenshade, PhD Javier Garzon, PhD Joel M. Goodman, PhD Julie G. Hensler, PhD Yoshiaki Hikasa, PhD Herbert Himmel, MD Keren I. Hulkower, PhD Peter C. Isakson, PhD Linda G. Jones, PhD Irwin Lucki, PhD David R. Luthin, PhD David J. Mangelsdorf, PhD John D. Minna, MD Sidney S. Negus, PhD Stephen T. O’Rourke, PhD Ebenezer T. Oriaku, PhD Tom J. Parry, PhD Margaret A. Phillips, PhD Arthur V. Prancan, PhD John D. Scott, PhD Dana E. Selley, PhD Laura Sim-Selley, PhD Quentin R. Smith, PhD Alan V. Smrcka, PhD Douglas K. Spracklin, PhD Kelly M. Standifer, PhD Yuichi Sugiyama, PhD Michael D. Swedberg, PhD Stephen F. Traynelis, PhD John R. Traynor, PhD Xinkang Wang, PhD James H. Wible, Jr, PhD Paula A. Witt-Enderby, PhD Yung H. Wong, PhD John D. York, PhD

ASPET 50 Year Members

ASPET thanks the following members who have devoted 50 years of service to ASPET and their commitment to the growth of our discipline.

Khalil Ahmed, PhD Desiree A. Armstrong, PhD Jack D. Barchas, MD William Stephen S. Brimijoin, PhD Gerald W. Camiener, PhD David E. Clarke, PhD Frank N. Dost, DVM Cristobal G. Duarte, MD Donald C. Dyer, PhD Carlton K. Erickson, PhD Morris D. Faiman, PhD Ralph I. Freudenthal, PhD Duane G. Gallo, PhD James E. Gibson, PhD Thomas M. Glenn, PhD Stanley D. Glick, MD, PhD Irving H. Goldberg, MD, PhD Joseph P. Hanig, PhD Israel Hanin, PhD Enrique Hong, DSc Susan Band Horwitz, PhD Garland A. Johnson, PhD Harvey R. Kaplan, PhD Gopal A. Krishna, PhD Atul R. Laddu, MD, PhD Yien-Hwei Lee, MD, PhD Ole J. Lorenzetti, PhD Myron A. Mehlman, PhD Thomas W. Mittag, PhD Alan S. Nies, MD Domenico C. Regoli, MD, PhD D. V. Sankar, PhD John H. Sanner, PhD Nguyen B. Thoa, PhD David J. Triggle, PhD Richard M. Weinshilboum, MD James H. Woods, PhD Raymond L. Woosley, Jr, MD, PhD

New Members

Postdoctoral Members

Pouria Fattahi, Univ of Pennsylvania Churchill J. Ihentuge, Univ of Pikeville, KY Monica R. Langley, Mayo Clinic, MN Antonio G. Soares, UT Health Science Center at

Houston, TX Shang Su, The Univ of Toledo, OH Wenli Yang, The Univ of Texas Health Science Center at Houston

Regular Members

Hosam G. Abdelhady, College of Osteopathic

Medicine Sam Houston Univ, TX Farzana Alam, Texas Tech Univ Health Sciences

Center El Paso Jacqueline Barker, Drexel Univ College of Medicine, PA Arti Bhujade, NJ Biopharmaceuticals LLC, NJ Jeremy W. Chambers, Florida International Univ Abhijit Date, Univ of Arizona Narsimhaswamy Dubasi, Belcher Pharmaceuticals LLC, FL Douglas C. Eaton, Emory University Medical School, GA Amber Frick, Univ of North Carolina Eshelman School of Pharmacy Peter J. Gaskill, Drexel Univ College of Medicine, PA Kristine Griffett, Auburn Univ, AL Saadet Inan, Lewis Katz School of Medicine at Temple

Univ, PA Sani M. Ismaila, The Univ of the West Indies, Trinidad

And Tobago Roger A. Laine, Louisiana State Univ Josh Lott, miLEAD Consulting, MI Subhi Marwari, Univ of Pennsylvania, PA Bryan McCranor, US Army Medical Research Institute of Chemical Defense, William D. McGuinn, Jr, Drug Development Services, IN Brooks McPhail, Univ of South Carolina School of

Medicine Greenville Shona A. Mookerjee, Touro Univ California Andreia C. Mortensen, Drexel Univ College of

Medicine, PA Khawla Nuseir, Jordan Univ of Sci & Tech= Emmanuel U. Onyekwelu, Legacy Univ & Classics/

Revits in Sci Med, Gambia Mayur S. Parmar, Nova Southeastern Univ, FL Kelsey Retting, Crinetics, CA Cai M. Roberts, Midwestern Univ, IL Vinay K. Sharma, NICHD, NIH, MD Bing Yang, The Univ of Tennessee Health Science Center Ling Yang, Shanghai Univ of Traditional Chinese

Medicin, China Yara Zayed, St. Michael’s Hospital, Canada Huiliang Zhang, Univ of Arkansas for Medical Sciences

Graduate Student Members

Sifat M. Alam, Univ of California San Diego Ashline Paul Manoucheca Amilcar, Instituto Nacional de Cardiología, Mexico Christina Besada, Drexel College of Medicine, PA Joanna A. Canagarajah, Drexel Univ, PA Breana Channer, Drexel Univ, NJ Matt Coban, Mayo Clinic, FL Laura Danner, Medical Coll of Wisconsin Paramita Gayen, Indian Inst of Sci Educ and Res

Kolkata Simran Gill, Drexel Univ College of Medicine, PA Gregory J. Grumbar, NIH/NIMH, MD Laura Huerta Sanchez, Univ of California Santa

Barbara Jennings Luu, Case Western Reserve Univ, CA Peter Nwokoye, University of Cambridge, United

Kingdom Emmanuel O. Okwuofu, III, Univ Putra Malaysia Nicholas Oldberg, Univ of California, Davis Katelyn L. Reeb, Drexel University College of Medicine, PA Daihyun Song, Univ of Minnesota Yearam Tak, St. Louis College of Pharmacy, MO Aruvi Vijikumar, West Virginia Univ

Undergraduate Student Members

Alexdiel Figueroa, Univ of Puerto Rico, Rio Piedras Megan E. Kohout, College of Saint Benedict, MN Md. Rasel Mahmud, University, Bangladesh Keelin Norman-Klatt, Beloit College, WI Caitlyn Nuehring, Univ of Northern Iowa Diandra Panasis, Rowan Univ, NJ Tanvikhaa Saravanan, Univ of Texas at Tyler, TX Hyogun Yi, Rutgers State Univ, NJ

Post-baccalaureate Student Members

Aanu Ayeni, Oregon Health and Science Univ Rebecca Schelling, NIH, MD

In Memoriam

ASPET notes with sympathy the passing of the following members:

Sue Piper Duckles, PhD, FASPET Marc G. Caron, PhD, FASPET

In Memoriam: Sue Piper Duckles, PhD, FASPET, 1946-2022

Submitted by Diana Krause, PhD

On January 24, 2022, Sue Piper Duckles passed away and we lost a distinguished and well-loved member of ASPET (1979-2022). Sue was an exceptional leader, an outstanding researcher, an invaluable collaborator, a sage mentor, an inspiring role model and a dear friend and colleague. She was a world-renown pharmacologist and a tireless advocate for advancing the discipline of pharmacology and the careers of pharmacology students and professionals.

A native Californian, Sue Piper Duckles grew up in the hills of Oakland which instilled in her a lifelong love of nature, hiking, camping, and native plant restoration. She obtained her B.A., cum laude, in Philosophy from UC Berkeley in 1968. At that time, she married Lawrence Duckles, a professional flutist, and also made the fateful decision to pursue a Ph.D. in Pharmacology & Toxicology at UC San Francisco. In 1973, Dr. Duckles moved to UCLA as an NIH Postdoctoral Fellow and then Assistant Professor in the Department of Pharmacology. From 1979 -1985, she was a pharmacology faculty member at the University of Arizona College of Medicine, Tucson, in the department of Dr. Thomas Burks, a key mentor in her career. In 1985, Sue was recruited to the Department of Pharmacology in the School of Medicine at UC Irvine, where she remained until her retirement as Professor Emerita in 2010.

In 2019, Sue Duckles was named to the inaugural class of ASPET Fellows for her overall impact on pharmacology and the Society. She provided outstanding leadership and guidance to ASPET, serving as President (19971998), Councilor (1992-1995) and on numerous committees. In recognition of her achievements, Sue was presented the ASPET Torald Sollmann Award in Pharmacology (2007) and the Paul M. Vanhoutte Award in Vascular Pharmacology (2014). Sue also received the PhRMA Foundation Award in Excellence in Pharmacology/Toxicology (2007) and was named an honorary fellow of the British Pharmacological Society (2005).

A gifted administrator and organizer, Sue Duckles also served as President (2006-2010), Secretary General (2002-2006) and General Assembly Delegate of the International Union of Pharmacology (IUPHAR). In addition, she was President of the Western Pharmacology Society (1992) and a member of the Board of Directors and Vice President for Science Policy for the Federation of American Societies for Experimental Biology (1997-2001). During her career, she helped organize numerous meetings and symposia; most notably, she was Congress President for the XIVth World Congress of Pharmacology held in San Francisco (2002). In addition, Sue provided strong leadership within her own institution, serving as Chair of the UCI Academic Senate (1990-1992), Interim Chair of the UCI Department of Pharmacology (2000-2005) and Associate Dean for Faculty Affairs and Development in the UCI School of Medicine (1993-2010).

As a cerebrovascular pharmacologist, Sue Duckles was world renown for her pioneering research on

the influence of sex hormones on the vasculature. Together with her long-time collaborator, Diana Krause, Sue discovered that estrogen acts directly on receptors in brain blood vessels to influence a variety of cellular and contractile responses. Groundbreaking studies by her research team established that estrogen protects vascular mitochondria by increasing mitochondrial efficiency and suppressing free radicals. Her studies elucidated mechanisms that underlie sex differences and hormonal influences in vascular function and age-related diseases such as stroke. In 1996, she helped organize a seminal ASPETsponsored colloquium, “Effects of gonadal steroids on vascular function” that brought hormone experts together with vascular biologists for the first time. For over 20 years, Sue contributed to and promoted the importance of the study of sex and hormonal influences in cardiovascular research.

When Sue joined ASPET in 1979, only about 10% of the members were women. To become a successful woman in science, Sue often had to break gender barriers and persevere with few role models and little mentorship. Sue constantly moved forward with confidence, smarts, a warm smile and laser focus on her goals. She was an excellent communicator, gifted writer and a natural leader who embraced collaboration. She was always firm, fair, respectful and kind.

Throughout her life and career, Sue Duckles had a profound influence on others. She was a powerful role model, especially for women in science. Sue was an outstanding advisor and example – of how to think critically and do good science, how to advance your career, and how to maintain balance and enjoy life. She modeled how to prioritize her interests and passions, which included her role as wife and mother. Sue used her position and experience to guide and support junior scientists and faculty members. A pioneer in promoting diversity and inclusion, she was an encouraging and supportive mentor for all.

Maybe because she started off studying philosophy, Sue had a unique perspective on a career in science. When asked to give a retrospective lecture on her journey, Sue titled it “A career in pharmacology: In search of beauty and joy”.

Sue Duckles is survived by her husband of 54 years, Lawrence Duckles, and her sons Ian (wife Heather) and Galen. She will be greatly missed and fondly remembered by her many students, mentees, co-workers and colleagues.

In Memoriam: Marc Caron, PhD, FASPET 1946-2022

Submitted by Laura M. Bohn, PhD

“Let’s read it out loud with feeling” is how Professor Marc Caron would begin a paper writing session. Every word read out loud, pausing to rewrite for clarity and flow, each paper receiving his attention and care. And indeed, there were many publications, all written with the desire to engage the reader and to share the science that Marc loved so much. Professor Marc Caron, passed away on April 25, 2022.

Dr. Caron held the title of a James B. Duke Distinguished Professor of Cell Biology at Duke University, where he also served as the Vice-Chair for Science and Research in the department. He received his PhD in 1973 from the University of Miami and had made Duke his academic home since 1977. Dr. Caron’s scientific accomplishments were wide in scope and impactful. He approached science with a desire to not only delineate mechanisms, but to understand the physiological impact of molecular-level findings. Marc published over 650 manuscripts and was awarded the Julius Axelrod Award in Pharmacology (2005) as well as the Goodman and Gilman Award in Receptor Pharmacology (2018) from the American Society of Pharmacology and Experimental Therapeutics (ASPET). He was a Howard Hughes Medical Institute Investigator for over a decade, a member of the American Academy of Arts & Sciences, and a fellow of the American Association for the Advancement of Science.

Many knew Marc for his seminal work on G protein couple receptor (GPCR) pharmacology; his early contributions include pioneering work cloning GPCRs and regulatory proteins and demonstrating their function in cellular models. Marc was the first to clone the D1 and D5 dopamine receptors and was the first to show that the dopamine D2 receptor signals through arrestins. Moreover, he was the first to show that morphine differentially regulated mu opioid receptor trafficking compared to enkephalins, laying the foundation for examining biased opioid receptor signaling. In more recent years, Marc identified new drug candidates for the neurotensin 2A receptor. Dr. Caron was known for extending his biochemical findings into biologically relevant neurological systems.

In addition to his work on GPCRs, Marc made seminal contributions to understanding neurotransmitter homeostasis. He famously described the hyperactivity of the dopamine transporter knock out (DAT-KO) mouse. This important model, along with others mouse models described in the laboratory, has served as an important model for studying Parkinson’s Disease, Huntington Disease, schizophrenia and attention deficit hyperactivity disorder. Indeed, Marc embraced new technological approaches and employed genetic models to understand the impact of molecular interactions on physiological responses; he was also known to be generous in sharing many of these models.

In addition to his highly productive research career, Marc was a true academic, serving his university and the scientific community in many ways: as a Center of Scientific Review study section member; course director; faculty mentor and recruiter; graduate student mentor and teacher. In 2018, he was honored for his mentorship, receiving the Research Mentoring Award for Basic Science at Duke. Dr. Caron was an editor for the Journal of Clinical Investigation and served as the editor for Biochemistry. Marc welcomed scientists from around the world to his laboratory and had an extensive network of collaborators. He was a welcomed addition to scientific programs as he was an excellent speaker, his passion and excitement for his research were readily shared.

Family was always very important to Marc and those of us who had the fortune to spend time in his lab, either as a trainee or a visiting scientist, can attest to that. He launched the careers of so many of us and we are grateful for his mentorship. Marc pushed us to be our best and to work hard, setting a strong example by his own dedication to research. Each Friday evening, he would leave the lab to say: “Have a good weekend, see you tomorrow…” We will miss you, Marc.

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