Land of opportunities for biosciences startup companies
Bilbao Bizkaia Startup
Strengths and drivers of Bilbao Bizkaia for biosciences startups
Strengths
Drivers
1
Macroeconomic Situation
1
Entrepeneur driven public institutions
2
Strategical Position
2
Friendly towards investment
3
Market Strength
3
Biosciences Incubators, space for entrepreneurs
4
R&D&i
4
Investment, introducing your best partners
5
Human Capital
5
Access to the most talented human capital
6
Infrastructures and Connectivity
6
International events related to biosciences economy
7
Working and Living in Biscay
7
Public advisory, all you need is us
Strengths of Bilbao Bizkaia for Biosciences startups
1. Macroeconomic Situation
Population
Metropolitan Bilbao: 1,100,000
Foreign population
7%
GDP per capita
â‚Ź 28,461
122% EU average
Biosciences companies
70 Basque companies
Employment in biosciences industry
26,500
2. Strategical Position
Thanks to its location in the European Union, Bilbao Bizkaia is a strategic hub for the establishment of your biosciences startup
Direct flights to European cities Paris London Brussels Berlin Frankfurt Munich Dusseldorf Sttutgart Milan Rome Oslo Lisbon Amsterdam Barcelona Madrid Istanbul Geneva Manchester
3. Market Strength
Spain´s 3rd strongest region for foreign direct investment, behind Madrid and Catalonia
700 Almost 700 foreign companies settled in the Basque Country
1000 M
13
20
12 20
11 20
10 20
09 20
08
People Employed in FDI companies = 11% of working population
500 M
20
61.000
999 M Basque Gross Investment Flow
3. Market Strength
Basque Biocluster exerts itself to stay a dynamic and open association that reflects the goals of its members
Almost
300
companies involved
BASQUE BIOCLUSTER
1,632
employees
268M turnover
211M exports
31M
investment R&D&i
Health-related (human or animal) biotechnologies
Bio-solutions for agro/food chains and environmental safety
Advanced materials and engineering
Turn-key lab/plant construction and systems
4. R&D&i Advanced science, technology and innovation system.
Technology Park of Bizkaia Workforce
7,647
R&D employees
27%
Global income
â‚Ź 2,455 mill.
Re s
219
Supporting infraestructures
Universities
on
Stablished companies
evelopment & In D & no h va c r a ti 4 3 e 9
Basic & excelence research centres
28 Intermediate bodies
Innovation Support Sub System
University and Scientifici Sub-System
7 Centres for cooperative research
ue
Eco
64
syste
19 Technological centres
n m : Bi o s ci e
ce
r
sq
Research & innovaction bussiness units
to
â‚Ź 170 mill.
More than per year allocated for Research, Development and Innovation in Bilbao Bizkaia
Technological Development Sub-System
14
Ba
First region in Spain according to GDP Invested in R&D&i 2,19% Above EU 2020 objectives
Laboratories & health r+d centres
e sS
c
4. R&D&i Specialised Technology and Research Centres: key factor in industrial competitiveness Technology Centres
123Mâ‚Ź
1,831
turnover
Staff Members
335
1,280
patents
Research Centres
145 105Mâ‚Ź
patents
turnover
researchers
1,310
Staff Members
CIC bioGUNE CIC biomaGUNE CIC microGUNE CIC nanoGUNE BIOEF Biocruces Onkologikoa, cancer CITA, Alzheimer Inbiomed, Regenerative Medicine
Key research areas: Personalised medicine and diagnostics.
Regenerative medicine.
Drug discovery.
Medical and CNS & different surgical devices. diseases
Biosensors and analytics.
Equipment and instrumentation.
Agrochemical uses of Biotechnology.
5. Human Capital
The Basque University Education is referent within the European Higher Education Area.
Deusto
MONDRAGON UNIBERTSITATEA
3rd European Region with the highest number of university graduates
67,551 University Students 8,769 biosciences sector related university studies
Young people with university degree
Bizkaia 43% Europe 24%
5. Human Capital
Degree
• • • • • • • • • •
Biology Biochemistry and Molecular Biology Biotechnology Science and Food Technology Environmental Sciences Physics Geology Mathematics Chemistry Medicine
• • • • • • • • •
Master
• • • • • • •
Forensic analysis Biomedical engineering Biomedical research Microbiology and health Molecular biology and biomedicine Neuroscience Pharmacology, development, evaluation and rational use of medicines Food quality and safety Nutrition and health Applied chemistry and polymeric materials Nanoscience New materials Physics and materials technologies Synthetic and industrial chemistry
• Theoretical chemistry and computational modelling • Advanced materials engineering • Chemical engineering • Control engineering, automation and robotics • Engineering physics • Environmental engineering • Renewable materials engineering • Research in environmental engineering • Photovoltaic devices and systems • Sustainable energy engineering
• • • • • • •
Human Nutrition and Dietetics Dentistry Nursing Pharmacy Environmental Engineering Chemical Engineering Industrial Chemical Engineering Manufacturing Ecotechnologies Biomedical Engineering
Deusto
MONDRAGON UNIBERTSITATEA
6. Infrastructures and connectivity
Metro & city tram
Network of railway lines
Road connections
Bilbao international airport
Metro and tram:
High Speed Train,
Road Connections:
Airport:
1.000 million users per year. Three minutes frequency. Complete coverage of metropolitan area.
will start operating in 2018: Madrid in 2 hours, Paris 5 hours.
Excellent transport links, which connects all municipalities in less than 40 minutes by road or public transport.
more than 4 million passengers per year. 10 minutes from Bilbao city center (12 Km).
6. Infrastructures and connectivity
Innovative infrastructures at the service of talent Animal facilities and animal models Cell Reprogramming and Differentiation core facility Structural Biology Platform (NMR, protein crystallisation, X-ray, electron microscopy) Pharma and biomanufacturing Basque Biobank, O+ehun (brains, tumours, peripheral blood - DNA, RNA, etc. - and other fluids) Metabolomics platform, mass spectrometry based Inbiobank (adult stem cells and primary cells), node of the National Bank of Cell Lines Genome analysis and gene silencing platforms Proteomics core facilities Molecular Imaging Facility (radiochemistry, MRI, SPECT, PET, CT, optical tomography) Dedicated biomedical Effectiveness Demonstration Unit and other clinical resources
6. Infrastructures and connectivity Cutting edge TIC infrastructures that cover all Bilbao-Bizkaia.
88% of the population access NGAs and 3G /4G technologies.
â‚Ź 72 mill. public budget allocated for the digital agenda.
Secure and trustable network
Cloud Computing boosted from the public institutions
Broad Band access 95% of the population
7. Working and Living in Bilbao-Bizkaia
1st
LivCom Prize in the category of Enhancement of the Natural and Built Landscapes
• High quality health care • Longest life expectancy in the EU. • Free and universal health system, reference as a quality service.
78,2 85,1 1st
1
st
Lee Kuan Yew World City Prize 2010 (Nobel Prize of Cities)
Best Urban Practices Award (Expo 2010)
1st
• Human Development Index Bizkaia • Above UE average rate, 0,738.
Città d´Acqua, Biennale di Venezia Architecture
7. Working and Living in Bilbao-Bizkaia
Culture 1 M annual visitors at Guggenheim Museum
Nature Beach 10 minutes away from city centre
Cultural Assets declared World Heritage by UNESCO
Bilbao is a reference in the European Art Network, and it complements the Bilbao-Bordeaux-Madrid Ant Axis.
Gastronomy 28 Michelin Stars in 2014
Bilbao is the 3rd most sustainable City in Spain 53% of its surface covered with trees. Natural Assets declared as Biosphere Reserve by UNESCOÂ
Drivers for a biosciences startup in Bilbao Bizkaia
1. Entrepreneur driven public institutions
1st
City with the best e-Administration in Spain according to the Internet Users Association (2010)
Openness
1st
Most transparent city in Spain in 2008, 2009, 2011 and 2012 according to Transparency International
Transparency
1st
Rigorous economic policies and strategic budget to ensure a stable economic network (zero debt, paid in 30 days)
4
th
Security
Southern European city in the overall and FDI strategy categories in the FDI European Cities and regional of the future ranking (2014)
Investment
Winner of the EPSA-European Public Service Award (2011)
1. Entrepreneur driven public institutions
Three public companies committed to digital contents startups in Bilbao Bizkaia.
Advice in obtaining licenses and permits Obtaining visa Connectivity Trademark Patenting
A consultant beside you 24/7 Funding & subsidies Constitution (PAE) Location Advisory Hiring
Centralised Point to help entrepreneurs Expedited incorporation: 2-3 days. Cheap incorporation: 100 â‚Ź Accompanying notary signature Administrative documentation Advice on legal forms
2. Friendly towards investment
Bizkaia legislates on direct taxes and establishes tax incentives and deductions for its businesses. Research Development 30-50% General tax 28%
New Non-Current Assets 10% (5% in asset improvement) Projects involving sustainable taxation 10-30%
Reduced to 24% for SMEs
Patent Box 30-60% (acquired or developed) Creation of employment 4,900€ per person Incentives related to funding (all companies)
Tax Deductions
Technological Innovation 15-20% (with Technological Centres) Tax Incentives for companies investing in startups: • Reduction in the tax base (60% of the invested amount) • Purchase of shares: maximum 100.000€ per investment
3. Biosciences Incubators, space for entrepreneurs
An advanced business incubator specialised in value added sectors Specialitation High Value added sectors and technologies: Bio-micronano technologies, Clean technologies and Advanced manufacturing
Installations Fully equiped with workrooms and laboratories for the development of the industrial and research activities.
Services
Kabi 612.
Focused on the growth 5.600m2 (4.5â‚Ź/m2/month) and 20MB the continuity of the companies: Elkartegiak. Acceleration, access (3-9â‚Ź/m2/month) 20MB to experts, training, investment rounds.
4. Investment, introducing your best partners
Specific public funding for every stage of the company life cycle. VCs Acquisitions/Mergers & Strategic Alliances Early Stage
250k
5,000-4,0000k Ekarpen
Later Stage
REVENUE
Gaitek
Angels, FFF Seed Capital
1500k 500k
Ekintzaile XXI
Ezten
400k
250k
Seed Capital Bizkaia
Pre-Seed Capital
95k
Incorporation
110k
project concept
180k
Corporate constitution
Valley of Death
Etorgai
Bideratu
Gauzatu
2,000k
1,000k
1,000k 50k
70k
Innovative Equipment projects Purchase
250k
Elkartzen
Basque Fondo II
120k
Internationalisation
500k Lanpar
500k
Elkano XXI
25k
Micro credits
100k
Basque Fondo
Grant TIME
Loan Capital
* Maximum amounts for each funding tool. Some of them would be subject to the European minimis rule.
4. Investment, introducing your best partners
Private funding agents in Bilbao Bizkaia are extremely proactive in searching startups to invest in. Private investment funds operating in Bilbao Bizkaia:
VCs Acquisitions/Mergers & Strategic Alliances Early Stage Angels, FFF
REVENUE
Seed Capital
>150k
CDTI Innovation
200k
Business Angels Network
Seed Funds
Later Stage
50k
Financial Entities
300k 150k
1,500k
Mutual Guarantee Societies
250k
Specialised funds
START DMC Argi Industrial Partners / UPLIFT S.L. MicroWave Ventures Emprendiza Samsung Venture Investment Kereon partners Abra Invest S.L. Crecer + Bulka Business Angels Inception Onza Vitamina k Entrecanales Sitka Capital Faraday Ventures Partners OnetoOne Corporate Finance DUMA Asociados Talde Ekarpen Caixa Capital Risk
ENISA
Entrepeneurs
25k
Social Entities
Endorsament Valley of Death
TIME * Maximum amounts for each funding tool. Some of them would be subjet to the European minimis rule.
Loan Capital
4. Investment, introducing your best partners Financial institutions in Bilbao-Bizkaia offer much more than just funds.
Finance
Advice
Training
Prizes
Micro credits and other BBVA Innovation instruments Centre
Yo soy empleo
BBVA Open Talent
Micro credits and other Startup advice instruments
BBK Fundazioa
BBK Ideas competition
Diverse financial products
Entrepreneur advice
Gaztelanbidean
New business ideas competition
Caixa Capital Risk MicroBanck
Advice for different entrepreneur profiles
Entrepreneurship programmes
XXI Entrepreneur awards
Financial instruments
Specialized advice
Trainning Courses
Bstart up
5. Access to the most talented human capital Benefits of hiring talent A digital contents company can take advantage of tax benefits from employement. Public Institutions promote Training on the job
Subsidies for training and development of human capital 1M€ aids/year. 120 professionals/year.
30% of the gross salary (Up to € 9,000 per person). Up to 90.000€ subsidy per company when employing staff.
Enterprises paying Social Security generate a credit in order to invest in training for employees. Public Institutions also offer subsidised training programmes for Basque employees, including specific programmes in R&D&i. Up to € 20,000 on Human capital training and specialitation Up to € 30,000 /person for hiring senior R&D&I employees Up to € 20,000 /person for hiring junior R&D&I employees Through our subsidiary Bizkaia Talent, we attract foreign qualified personnel.
* In addition to all this bonus in Social Security Tax for researchers: 40% of the company¨s contribution for common contingenices
5. Access to the most talented human capital
UE
No work permit needed
Non UE
Work permit + Visa
Foreign Employees
Foreign Entrepreneurs
Job Offer
Company Registration
Residence and Work Permit
Residence and Work Permit
Visa
Visa 14/2013 Law for Entrepreneurs support and their interntionalization WHO: Investors Entrepreneurs Highly qualified professionals R&D&I development In company transfer
WHERE
(one-stop-shop): Residence authorisation: Strategic Collective UnitMinistery (resolution in 20 days) Visa: Spanish consulate country of origin (resolution in 10 days)
HOW: Passport or identity document (applicants must be over 18) Medical insurance accreditation document Criminal record certificate Economic means accreditation
6. International events related to biosciences economy
International events in Bilbao
Facilities to host international events
7. Public Advisory, all you need is us
Beaz S.A.U. is the company
Bilbao Ekintza is a
SPRI S.A. is the Business
of the Department of
Local Business Public
Development agency of the
Economic Promotion of
Entity (EPEL) created to
Autonomous Region of the
Biscay´s Provincial Council,
generate economic and
Basque Country, to promote
responsible for the
social wealth in the city,
the country as an attractive
development of innovative
enhancing its capabilities
place to invest in, and the
business projects and the
as a destination for
promotion of business
fostering of high growth
investment, business
dealings between foreign
startups, both local and
creation and growth,
and Basque companies.
foreign.
attracting visitors and talent.
For further information contact: foreignstartups@beaz.net
European Union European Regional Development Fund