PRODUCT INFORMATION
ketalean®
N
Ketamine Hydrochloride Injection USP Sterile DIN 00612316
INDICATIONS
Description
A general anaesthetic for use in cats only.
Ketamine HCl injection. Rapid acting, non-barbituate general anesthetic. Recommended as the sole anesthetic agent for diagnostic and surgical procedures. Although best suited for short procedures, it can be used, with additional doses, in procedures requiring anesthesia for periods of six hours or longer.
PACKAGING See reverse side for Administration and Dosage.
ITEM NO.
UNIT PACKAGE
CASE SIZE
1KET002
50 mL
12
Bimeda - MTC Animal Health, Inc. • Beaverdale Road, Cambridge, Ontario N3C2W4 Tel.: (519) 654-8000 / Fax.: (519) 654-8001/ sales@bimedamtc.com / www.bimedamtc.com
TECHNICAL INFORMATION
ketalean®
N
Ketamine Hydrochloride Injection USP Sterile
DIN 00612316
Caution: For intramuscular use in cats only.
Veterninary Use Only ACTIVE INGREDIENT: Ketalean is a rapid acting, non-barbiturate, general anesthetic for cats. It contains 115.4 mg/ML ketamine hydrochloride (2-(o-chlorophenyl)-2-methylamino-cyclohexanone hydrochloride) providing the equivalent of 100 mg/mL ketamine base. Ketalean is supplied as a slightly acidic (pH 3.5-5.5) solution for intramuscular injection and contains 0.01% benzethonium chloride as preservative. Ketalean is available in 10 mL and 50 mL vials. Action: Ketalean is a rapid acting anesthetic producing an anesthetic state characterized by profound analgesia, normal pharyngeal-laryngeal reflexes and skeletal muscle tone, mild cardiac stimulation and some respiratory depression. The anesthetic state produced by ketamine has been termed “dissociative anesthesia” in that it appears to selectively interrupt association of the brain before producing somesthetic sensory blockade. Following administration of recommended doses of Ketalean, blood pressure and heart rate are usually moderately and transiently increased. Respiratory rate on the other hand, is usually decreased in cats. The pharyngeal reflexes are maintained thus adding in maintenance of a patient airway. Although some salivation is occasionally noted, the persistence of the swallowing reflex effectively reduces the hazards of salivation. Other reflexes, e.g. corneal, pedal, etc., are maintained under Ketalean anesthesia, and should not be used as criteria for depth of anesthesia. Moreover, the eyes normally remain open with the pupil dilated, making it prudent to apply a bland ointment if anesthesia is to be prolonged. By single intramuscular injection in cats, Ketalean has a wide margin of safety. Following administration of recommended doses of Ketalean, most cats become ataxic in about 5 minutes, and anesthesia will normally last 30-45 minutes. Recovery is generally smooth and uneventful, especially if animals are not stimulated by sound or handling during the recovery period. At the lower doses, complete recovery usually occurs in 4-5 hours, but with higher levels of Ketalean, recovered time is more prolonged and less predicable. With high levels, complete recovery may take 24 hours or more in some selected cases especially if the patient is in poor condition or suffering from nephritis. Indications: Ketalean is recommended as the sole anesthetic agent for diagnostic and surgical procedures. Although best suited to short procedures, it can be used, with additional doses, in procedures requiring anesthesia for periods of six hours or longer.
Contraindications: The use of Ketalean is not indicated in kittens under 12 weeks of age as it is not unusual in immature cats for anesthesia to be of shorter duration. Ketamine hydrochloride is contraindicated for procedures in cats requiring complete skeletal muscle relaxation. Precautions: Because the drug is excreted in the urine by cats, largely unchanged, caution should be exercised in dosing subjects with severe renal impairment. Caution should also be exercised in administering the drug to animals with cardiovascular abnormalities due to its hypertensive effect in cats. Premedication with atrophine may, to some degree, deepen and prolong anesthesia in the cat. Adverse Reactions: At high dose, respiratory depression may occur. If at any time cyanosis occurs, or if respiration becomes excessively depressed, resuscitative measures should be instituted promptly, e.g. artificial respiration, oxygen administration, etc. Dosage and Administration: Ketalean is well tolerated by cats when administered by intramuscular injection. Fasting prior to induction of anesthesia by Ketalean is not essential, however, when preparing for elective surgery, it is prudent to withhold food for at least six hours prior to induction of anesthesia. As with other anesthetic agents, the individual response to Ketalean is somewhat varied depending on the dose, general condition, and age of subject so that dosage recommendations can not be absolutely fixed. The following schedule of dosage is recommended: 11-22 mg/kg body weight: MINOR SURGERY, SUTURING, ETC., MINOR DENTAL PROCEDURES, SIMPLE DIAGNOSTIC X-RAY, RESTRAINT FOR EXAMINATION (INCLUDING INTERIOR OF EYE), DRESSING, GROOMING, ETC. 22-33 mg/kg body weight: CASTRATION, CATHETERIZATION, DECLAWING. 33-44 mg/kg body weight: GENERAL SURGERY, ABDOMINAL SURGERY (INCLUDING OVARIOHYSTERECTOMY) ORTHOPEDIC SURGERY, MAJOR DENTISTRY. Storage: Store at room temperature between 15°C-25°C. DO not freeze. Protect from light. Color of solution may vary from colourless to very slightly yellowish and may darken upon prolonged exposure to light. This darkening does not affect the potency. Do not use if precipitate appears. 1KET002/8KET004B
Bimeda - MTC Animal Health, Inc. • Beaverdale Road, Cambridge, Ontario N3C2W4 Tel.: (519) 654-8000 / Fax.: (519) 654-8001/ sales@bimedamtc.com / www.bimedamtc.com
8KET004B Ketalean_Tech_03/11