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In recent readership surveys, you told us that you prefer the convenience and accessibility of a standard magazine size format. And so, effective with this 40th anniversary issue, Lab Product News has shed its decades-old tabloid size and is relaunching in this format. In this redesigned format, you’ll find the same mix of products and news to keep you up-to-date with everchanging laboratory technology. Lab Product News’ sister publication, the Lab Buyers’ Guide, will continue to bring you information about sourcing laboratory products in Canada, in print and online.

And check out our website, www.labcanada.com. It’s updated regularly with news and products, along with a host of other online features. While there, be sure to use a convenient new service – an online Reader Reply Card. Good for all the products that appear in the magazine, every subscriber can use this online request service to get more product data quickly and easily. Leslie Burt Publisher / Editor lburt@labcanada.com

LAB PRODUCT NEWS • 04/10 • labcanada.com

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Leslie Burt lburt@labcanada.com ART DIRECTION Pete Pepperman Lisa Zambri CIRCULATION MANAGER Diane Rakoff PRODUCTION MANAGER Karen Samuels ksamuels@bizinfogroup.com READER SERVICE Elizabeth Callaghan ASSOCIATE PUBLISHER Anita Havas-Stainton ahavas-stainton@labcanada.com PUBLISHER/EDITOR

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Bruce Creighton HEAD OFFICE: 12 Concorde Place, Suite 800, Toronto, Ontario M3C 4J2. Fax (416)510-5140. Telephone direct (416)510-6835. Email: lburt@labcanada.com. LAB PRODUCT NEWS is published by BIG Magazines LP, a div. of Glacier BIG Holdings Company Ltd. BIG Magazines LP is a leading Canadian information company with interests in daily and community newspapers and business-to-business information services. EDITORIAL PURPOSE: To provide concise product data for buyers, specifiers and users of laboratory equipment. Readers in industry, hospital, university, private and government laboratories are informed about the latest equipment suitable for their particular branch of science. CIRCULATION: This publication is mailed to eligible recipients in Canada who work in these Laboratory Classifications: Industrial labs (Quality Control & Research/ Development); University labs; Community College & High School labs; Hospital & Medical labs; Government labs; Private (independent) labs. Subscription rate in Canada: $35.95/year; $57.95 for two years; USA $65.95/year; other countries, $104.95/year. CHANGE OF ADDRESS: Please call (416) 442-5600, ext 3548 or email mmarasigan@bizinfogroup.ca for changes and updates to your subscription. Laboratory Product News assumes no responsibility for validity of claims in items reported.

10 Lab Product News recently visited Pittcon 2010 in Orlando, FL. See our Show Report for a sampling of the new and innovative products on display at this world-leading exhibition and conference.

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at CERN, July 2007. See story, page 6

Photo credit: The ATLAS Experiment at CERN, http://atlas.ch

INDUSTRY NEWS

labcanada.com • 04/10 • LAB PRODUCT NEWS

PARTICLE ACCELERATOR

makes record-shattering start

n March 30, beams collided at 7 TeV in the Large Hadron Collider (LHC) particle accelerator at the CERN Laboratory, which is around 100 m underground and straddles the border between France and Switzerland near Geneva. The collision fully launched the ATLAS particle physics ex-

periment and shattered existing collision records. In this first run, particles were collided at an energy level three and a half times higher than previously achieved by a particle accelerator. The goal of the project is to learn about the basic forces that have shaped our universe since the beginning of time and that will determine its fate. Among the possible unknowns are the origin of mass, extra dimensions of space, unification of fundamental forces, and evidence for dark matter candidates in the universe. “With these record-shattering collision energies, the LHC experiments are propelled into a vast region to explore, and the hunt begins for dark matter, new forces, new dimensions and the Higgs boson,” said Fabiola Gianotti, ATLAS collaboration spokesman. Following this run, CERN will shut LHC down for routine maintenance, and to complete work needed to reach its design energy of 14 TeV. After that, it is planning to run the LHC for 18-24 months before shutting it down for maintenance. CERN, the European Organization for Nuclear Research, is one of the world’s largest centres for scientific research. Its business is fundamental physics. Founded in 1954, it was one of Europe’s first joint ventures and now has 20 member states. LAB PN

View of the ATLAS detector at CERN, July 2007. Photo credit: The ATLAS Experiment at CERN, http://atlas.ch

New research institute has country’s largest biobank

he David Braley Cardiac, Vascular and Stroke Research Institute at the Hamilton General Hospital recently celebrated its grand opening. The six-storey research institute includes 200,000 sq ft of research space and labs. It also houses Canada’s largest biobank which stores more than 1.8 million tissue and genetic research samples from around 250,000 participants. Two world-class research teams will be located in the centre - the Population Health Research Institute, led by Dr Salim Yusuf, and the Thrombosis and Atherosclerosis Research Institute, led by Dr Jeffrey Weitz. The building is named after David Braley, president of Orlick Industries, who donated $10 million to the project. LAB PN

L-R: Dr Salim Yusuf, Hamilton Health Sciences and Population Health Research Institute, Mrs Wahida Yusuf, Dr Julie Masterson, Dr Eliot Phillipson, Canada Foundation for Innovation, David Braley, Orlick Industries, Dr Alain Beaudet, Canadian Institutes for Health Research, David Sculthorpe, Heart and Stroke Foundation of Ontario, Nancy Gordon, Mark Rizzo, Hamilton Health Sciences, Murray Martin, Hamilton Health Sciences, Dr Jeffrey Weitz, Thrombosis & Atherosclerosis Research Institute.

COMING EVENTS MAY 3-6, BIO 2010, Chicago, Biotechnology Industry Organization, T: 202-962-9200, F: 202-589-2545, info@bio.org, www.bio.org MAY 8, SCIENCE RENDEZVOUS, Greater Toronto Area, T: 416-978-1457, rendezvous@optics.utoronto.ca, www.sciencerendezvous.ca MAY 9-12, 21ST CANADIAN SYMPOSIUM ON CATALYSIS, Banff, Chemical Institute of Canada, T: 613-232-6252, F: 613-232-5862, conferences@cheminst.ca, www.21csc2010.ca

MAY 10-13, 8TH BIENNIAL CONFERENCE ON MONITORING AND MEASUREMENT OF THE ENVIRONMENT, Toronto, T: 416-235-5906, F: 416-235-5744, ray.clement@ontario.ca, www.enviroanalysis.ca MAY 11, NEWFOUNDLAND AND LABRADOR LABORATORY EXPOSITION, St John’s, Canadian Laboratory Suppliers Association, T: 519-579-7598, F: 519-579-8134, jhowes@clsassoc.com, www.clsassoc.com

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INDUSTRY NEWS

labcanada.com • 04/10 • LAB PRODUCT NEWS

Partnership focusses on photonics research

he Ontario Centres of Excellence (OCE) and OptoNet, a Germany-based optical technology cluster, signed a oneyear cooperation agreement in February. Under the agreement, the parties will collaborate on joint R&D activities, particularly between research centres with a

CFI the world’s best funding body

special focus on healthcare, information and laser technologies. It will also encourage exchanges of students, academic staff, researchers, post-doctoral fellows. “On behalf of Thuringia and OptoNet we are pleased to be part of this international collaboration with Ontario Centres of Excellence in this very exciting field,” said Matthias Machnig, minister of economy, labour and technology, Free State of Thurignia. LAB PN

L-R: David Choat, OCE; Tony Rockingham, Ministry of Research and Innovation; Matthias Machnig, Free State of Thurignia; and Dr Ulrich Simon, OptoNet sign the cooperation agreement.

he Canada Foundation for Innovation (CFI) is the most successful research funding organization of its kind in the world, says an internationally renowned panel of experts. “The panel is unanimously of the view that the CFI’s record of achievement to date is outstanding,” said panel chair Arthur May, who is also president emeritus and vice-chancellor of Memorial University of Newfoundland. “The CFI is widely admired internationally and, indeed, is a model that has been and will be emulated elsewhere.” KPMG conducted an overall performance evaluation and value-for-money audit and an international panel of seven experts in global research and research funding reviewed the findings and produced an independent report. The report was released in late March and can be viewed at the CFI’s website at www.innovation.ca.

$150M research centre breaks ground

roundbreaking ceremonies were held in March for the new Krembil Discovery Centre at the Toronto Western Hospital (pictured at right in artist’s conceptual image). Named for lead donors Robert and Linda Krembil, the $150-million research centre, which will open in 2013, will house research into stroke, brain tumours, Parkinson’s disease, Alzheimer’s disease, spinal-cord injury, glaucoma, and arthritis. Once completed, the 9-storey research facility will include 150,000 sqft of lab space and 50,000 sqft of clinical research space. Dr Robert Bell, president and CEO of the University Health

Network, which includes Toronto Western Hospital, says he anticipates that the Tanz Centre for Neurosciences, presently housed at the University of Toronto, will also move to the new site. LAB PN

COMING EVENTS MAY 16-19, 2010 AAPS NATIONAL BIOTECHNOLOGY CONFERENCE, San Francisco, American Association of Pharmaceutical Scientists, T: 703-243-2800, F: 703-243-9054, MayS@aaps.org, www.aapspharmaceutica.com MAY 17-18, DISCOVERY, TORONTO, Ontario Centres of Excellence, T: 416-861-1092 Email:catharine.ogilvie@oce-ontario.org, www.oce-ontario.org MAY 18-21, HUGO HUMAN GENOME MEETING, Montpellier, Human Genome Organisation, T: +44-20-7935 8085, F: +44-20-7935 8341, hugo@hugo-international.org, www.hugo-international.org MAY 23-27, 58TH ASMS CONFERENCE ON MASS SPECTROMETRY, Salt Lake

City, American Society for Mass Spectrometry, T: 505-989-4517, F: 505-989-1073, office@asms.org, www.asms.org MAY 28-JUNE 1, LABCON, Edmonton, Canadian Society for Medical Laboratory Science, T: 905-528-8642, F: 905-528-4968, Alison@csmls.org, www.csmls.org MAY 29-JUNE 2, THE 93RD CANADIAN CHEMISTRY CONFERENCE AND EXHIBITION, Toronto, Chemical Institute of Canada, T: 613-232-6252, F: 613-232-5862, conferences@cheminst.ca, www.csc2010.ca JUNE 21-25, NANOTECH 2010, Anaheim, Nano Science and Technology Institute, T: 508-357-2925, F: 925-886-8461, info@nsti.org, www.nsti.org

INDUSTRY NEWS

LAB PRODUCT NEWS • 04/10 • labcanada.com

Chemicals forum to inform about looming European deadlines

n late May, the European Chemicals Agency (ECHA) – the body responsible for managing the REACH process based in Helsinki, Finland – is providing the international chemical industry with the opportunity to find out more about its looming REACH deadlines. REACH (which stands for registration, evaluation, authorization and restriction of chemicals) was brought into force in mid2007, and is intended to protect consumers and the environment from hazardous chemicals. It shifts the responsibility of safety from governments to companies –

including all producers and importers of chemicals into Europe – which are now required to demonstrate the safety of their products. The objective is ultimately to phase out or ban the most hazardous chemicals from Europe. To be banned, a chemical must first be placed on ECHA’s Candidate List of Substances of Very High Concern. There are currently around 30 substances on the candidate list. A full list of candidate chemicals is available on ECHA’s website at http://echa.europa.eu/chem_data/ authorisation_process/candidate_list_table_en.asp. Decisions will be made later by member states of the European Union as to whether or not these substances are LEFT: Stakeholders Day sessions in progress, May 2009 (Copyright European Chemicals Agency) BELOW: ECHA headquarters in Helsinki, Finland (Copyright European Chemicals Agency)

actually banned and/or substitute chemicals required. The first deadline for registration of all chemicals being produced or imported into Europe is on December 1, 2010. Ultimately, every chemical produced or imported into Europe in significant quantities has to be tested, which will be paid for and actually done by the producer or importer. On May 19, ECHA will hold a stakeholder day in Helsinki, providing a forum for more information about REACH and its deadlines. ECHA spokespeople will also be setting aside time for one-on-one interviews with interested parties, in order to facilitate an open dialogue between industry and regulators. ECHA’s event will be followed by the second global Helsinki Chemicals Forum (HCF) on May 20-21 at the same premises. Whereas the ECHA day will focus mainly on REACH, HCF provides a high-level forum to discuss cutting-edge questions on the importance of chemical substances in our modern world and on the regulation of their use globally, as well as the possibilities brought by chemistry to contribute to safe and high-quality life. It covers issues such as chemical policies in emerging economies, competitiveness in the chemical industry, and green chemistry. REACH is a measure that will have a major impact on the worldwide chemical industry, and these events are a significant opportunity to receive advice and provide input as the regulations are finalized. More information, including the program details, on the ECHA Stakeholders’ Day and on the Helsinki Chemicals Forum, is available at http://echa.europa.eu/ news/events/4rd_stakeholders_day_en.asp and www.helsinkichemforum.eu. LAB PN

IN BRIEF Dr Calvin Stiller, Ontario Institute for Cancer Research, has won the Canada Gairdner Wightman Award. A builder of institutions that enrich Canada’s research landscape, he is also a pioneer in multiple organ transplants and diabetes.

The Society for Biomolecular Sciences and the Association for Laboratory Automation are considering a merger, and members have until May 5 to vote on the plan. The new organization will be called The Society for Laboratory Automation and Screening.

Analytical instrument maker AB Sciex has acquired the liquid chromatography business of Eksigent. “Eksigent’s portfolio of HPLC technologies is among the most innovative within the industry,” says Andy Boorn, president of AB Sciex.

PITTCON 2010

labcanada.com • 04/10 • LAB PRODUCT NEWS

PITTCON CONFERENCE & EXPO February 28-March 5 The Orange County Convention Center in Orlando, FL was the site for the 61st annual Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy. As well as an outstanding Technical Program, there were over 800 exhibitors in 2000 booths, showcasing their latest lab products. Below, and on the next six pages, are some of the products that the staff at Lab Product News thought would be of interest to our readers.

2010

DATABASE SPEEDS COMPOUNDS CHARACTERIZATION Developed for aroma and chemical characterization by gas chromatography (GC) analysis, library uses Kovats Index as a reference method and offers rapid characterization of compounds and fast sample screening. It includes 2,900 compounds of which 1,400 are with sensory attributes. Chemical information (name, formula, CAS number, molecular weight, retention index) is available for several columns, including methylpolysiloxane, methyl 5% phenyl polysiloxane, cyanopropylphenyl 14% dimethyl polysiloxane 86%, polyethylene glycol. For a selected peak on a chromatogram, the library proposes a list of possible compounds. To facilitate identification, the compounds are sorted based on a unique recognition accuracy index. Alpha MOS Reply card # 20

MS-BASED APPLICATION FOR LIPIDOMICS STUDIES

PEPTIDE SYNTHESIZER COMBINES TWO TECHNOLOGIES

The developer says this is the first mass-spectrometry (MS)-based software application specifically designed to advance the study of lipidomics. The software uses the analytical accuracy and speed of mass spectrometry to characterize molecules in studies of lipidomics, which is an emerging field of systems biology being applied for disease research, drug discovery and biomarker research for potential use in clinical settings. This automated data processing tool enables researchers to more effectively identify and quantify lipids from complex samples, providing standardized information from a catalog of more than 40 lipid classes and 23,000 possible lipid species. AB Sciex Reply card # 26

Microwave and parallel peptide synthesizer the a result of a joint development project between Biotage and MultiSynTech. It combines the performance of MultiSynTech’s robotic synthesizer with Biotage’s microwave technology. The peptide synthesis system offers both microwave and parallel peptide synthesis capabilities. To date, peptide synthesis labs have been required to invest in both standalone parallel systems for productivity and cost efficiency, and standalone microwave systems for difficult or longer peptides. The new system reduces demand for bench space, ends the duplication of computer control systems, and eliminates the need for chemists to learn and maintain multiple software platforms. Biotage Reply card # 23

PITTCON 2010

LAB PRODUCT NEWS • 04/10 • labcanada.com

rc28

rc25 rc21

rc22 LC RUNS AT COLUMN PRESSURES UP TO 10,000 PSI Microscale HPLC (high-performance liquid chromatography) system runs at column pressures up to 10,000 psi, allowing the use of sub-2 micron particle columns. Along with a new UV detection system, the system is designed to deliver the advantages of microscale LC including solvent savings, reduced sample requirements, and reduced frictional heating. The CCD-based UV detector works with microfabricated flow cells to ensure ultra-high sensitivity with no band broadening. The high UV sensitivity allows detection of impurities at levels as low as 0.05%, meeting the needs of researchers in drug discovery and many other applications. Eksigent Reply card # 25

LAB-SCALE SPRAY DRYER ADVANCES PRODUCT DEVELOPMENT Spray dryer expands spray drying possibilities into the nano range. The technology for particle generation uses minimal sample quantities and achieves very high product recovery rates. The instrument is designed to evaluate drying during the early stages of product development in the pharmaceutical, food, advanced materials, and nanotechnology industries for aqueous or solvent-based formulations. A piezoelectric driven actuator vibrates a thin, perforated membrane in a small spray cap. The actuator is driven at ultrasonic frequency, causing the membrane to vibrate, creating precisely sized droplets with very narrow droplet distribution. Buchi Reply card # 28

LABELS WITHSTAND HARSH ENVIRONMENTS Customized, high-performance labels for histology and pathology laboratories are designed to address a variety of laboratory needs including reliable performance. The labels offer an alternative to ink-jet printing or hand marking. In addition, the label system uses minimal laboratory countertop space. The labels are resistant to harsh chemicals and extreme temperatures. The line includes three core histology and pathology applications. They are available as print-ondemand in conjunction with the manufacturer’s printers and label design software. Computype Reply card # 22

LOW-ENERGY FUME HOOD HAS MODULAR FILTER DESIGN Ductless fume hood is designed for flexibility with a modular filtration column system. The filtration technology allows the use of liquids and solids individually or together. The fume hood also consumes very low levels of energy. Modular design with one-size ventilation and filtration cartridges means the user can rearrange the filtration column stack, and can add single or double layers of super-activated carbon filters with HEPA filter to meet varying needs. Manufacturer says the filters make exposure of chemicals 100 times lower than levels mandated by OSHA. Gel sealing technology on the perimeter of the cartridges uses gravity to ensure that the filtration column stays perfectly airtight. Erlab Reply card # 27

ULTRASONIC CLEANER HAS HIGH POWER AND CONTROL Dual frequency ultrasonic cleaner dissolves difficult samples and removes tenacious contaminants, allowing delicate instruments to be safely cleaned at 80 kHz. The cleaner allows total control of ultrasonic power, frequency, mode, time and temperature across a wide range of cleaning and mixing tasks. According to the manufacturer, the cleaner has the highest average and peak ultrasonic power commercially available. Available in 6 tank sizes from 0.75 to 7.5 gallons, the units operate at 37 or 80 kHz in four ultrasonic modes for cleaning, intense cleaning, dissolving and degassing. Tovatech Reply card # 21

LAB SOFTWARE SUITE UNIFIES DATA SYSTEMS Software portfolio is designed to provide a better way for labs to efficiently capture, share, review and archive scientific data. It consists of three integrated solutions: chromatography data system, and electronic lab notebook, and enterprise content manager. The system is designed for small standalone analytical labs through global networks with hundreds of locations, and is designed to grow with the lab. It is instrument vendorneutral and provides easy migration paths from existing systems, protecting customers’ investments. Agilent Technologies Reply card # 24

PITTCON 2010

labcanada.com â&#x20AC;˘ 04/10 â&#x20AC;˘ LAB PRODUCT NEWS

RAMAN SPECTROMETER HAS SMALLER, LIGHTER DESIGN

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Rugged handheld Raman spectrometer is designed for use by forensic chemistry personnel, along with first responders. The instrument allows users to quickly identify unknown chemicals from a vast sample library of more than 10,000 pure substances including: explosives, toxic industrial chemicals, toxic industrial materials, chemical warfare agents, white powders, narcotics, precursors and more. Advanced chemometric algorithms enable automatic mixture analysis with every scan and ensure the user can be confident in the accuracy and reliability of results. Ahura Scientific Reply card # 32

rc30 POLARIMETER USES RFID FOR QUICK USER ID Radio-frequency identification (RFID) technology allows polarimeter to provide rapid clearance to multiple operators when working in an FDA-controlled environment. RFID is particularly useful where a number of different operators use the instrument in a controlled environment such as those working to GLP or FDA regulation 21 CFR Part 11, where a long PIN would normally be input via the keypad for clearance and recording purposes. RFID tags store personal access data and with the simple swipe of a tag across the instrument housing, the user is verified and given the applicable access rights. Instrument also has a new blue-screen display and updated menu structure. Bellingham & Stanley Reply card # 29

DATA COLLECTOR FOR AQUATIC, CLIMATE MONITORING

CE PLATFORM IS FOR PHARMACEUTICAL ANALYSIS

String logger and real-time data collector provides synchronized and distributed oceanographic, aquatic, and climate monitoring instrumentation. Options include either a commercial off-the-shelf, self-contained unit and/or an integrated plug-andplay observation system solution. The instrument is user configurable, allowing for the creation of an observational data network without the costs associated with a custom solution. Suitable for river, lake, and ocean conditions, including current, wave, tide, temperature, salinity, CTD oxygen, 600kHz doppler current profiler, weather station, and buoy systems. Aanderaa Data Instruments Reply card # 30

Capillary electrophoresis (CE) platform was designed in collaboration with biopharmaceutical development and QC groups and provides quantitative determination of biologic purity and heterogeneity. The robust and easy-to-use characterization platform integrates quantitative, qualitative and automated solutions for analysis of protein purity, charge isoform distribution and glycan structure. An emphasis on the portability of assays between laboratories enhances system utility in multi-user/multi-instrument facilities. Universal methods address gradient stability and protein solubility, and new synthetic pI markers attain high levels of precision in pI calculation and isoform quantitation. Beckman Coulter Reply card # 31

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FIRE PROTECTION FOR FUME HOODS AND CABINETS Stand-alone automatic fire detection and suppression systems are designed for fume hoods and cabinets and hazardous material storage cabinets. The detection and suppression system is located behind the baffles and across the exhaust duct openings. It uses purpose-designed leak-resistant polymer tubing that is linked to an extinguishing agent cylinder via a custom-engineered valve. The tubing is actually a linear pneumatic heat and flame detector that ruptures anywhere along its length immediately when fire is detected and automatically releases the suppression agent. Firetrace International Reply card # 34

PITTCON 2010

LAB PRODUCT NEWS • 04/10 • labcanada.com

INSTRUMENTS MONITOR THERMOSENSITIVE PRODUCTS Mini-wireless cold-chain monitor and wired temperature recorder with a colourchanging face are designed for easy readout measure and control temperature and hygrometry during storage and transport of thermosenswwitive products. They can be used in biological and medical chambers (blood bags, reagents, medicines, vaccines), ultra-low freezers, ovens, incubators, diagnosis machines, liquid nitrogen tanks (-196°C), vehicles or isothermal boxes for blood transport. The recorders enable wireless communication and can be adapted to any mobile chamber. The unbreakable and splash-proof data logger is for cold-chain monitoring. JRI Maxant Reply card # 35

GAS MONITORING SYSTEMS WORK REMOTELY Three models of remote gas monitoring systems for laboratory gases are available at different price points, including a wired, low-cost system and two wireless solutions to efficiently monitor gas pressure or liquid levels in cylinders. The basic system uses a wired connection and monitors gas pressure from up to 16 sources. The second model is completely wireless and can monitor data from any device with a gauge face or that produces a 4 to 20 ma or a 0 to 5 vdc signal. The third is part of a line of fully automatic PLC-based changeover manifolds that can be connected to a laboratory computer network. Airgas Reply card # 33

MICROWAVE SYSTEM SPEEDS DIGESTION Available in two configurations, microwave digestion system is designed to improve sample throughput and speed of digestion and to reduce labour and human intervention. The instrument has a tunnel system employing 12 dynamically operating micro cavities to process 12 samples simultaneously. Other features include individual sample temperature control and monitoring; seamless microwave power control with no duty cycle; built-in EPA and DIN methods; and USB/Ethernet port connectivity for data processing and storage. The system handles up to 168 samples at once. SCP Science Reply card # 36

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PITTCON 2010

LAB PRODUCT NEWS • 04/10 • labcanada.com

WOOD FURNITURE BRINGS TRADITION TO LABS Traditional quality craftsmanship combined with computerized engineering processes and high-tech machinery bring aesthetics and durability to the lab. A full range of cabinetry and components is available in wood veneers, with various cuts, matching and sequencing options. Multiple stains and custom staining are available for matching to existing casework. Manufacturing operation meets or exceeds strict air quality and emission level criteria, and the manufacturer’s state-of-art UV flat line system does not release VOCs. FSC-certified and sustainable materials are also available, with no added urea-formaldehyde (NAUF). Mottlab Reply card # 37

LIMS EXTENDS FUNCTIONALITY TO CLINICAL LABS Configurable off-the-shelf laboratory information management system (LIMS) is designed to manage an organization’s laboratory information across its worldwide R&D pipeline and manufacturing supply chain. A new protocol management tool supports clinical protocols, and an electronic forms feature provides a configurable approach to creating and filling out data forms electronically. Without requiring programming skills, it replaces the traditional way of interacting with paper forms and curtails the learning curve required for familiarizing with new software applications. LabVantage ReplyGenevac card # 39 Rocket LabPN halfhor 0210:Layout 1 26/2/10 14:34

MICROSCOPE OFFERS ADVANCED 3D IMAGING New-generation digital microscope system offers 3D imaging solutions, with the digital camera, light source, LCD monitor, computer and software all integrated into one unit. The microscope is easy to use, and provides a comfortable observation environment and no complex operations. A newly developed 3D modelling algorithm and high-precision motorized Z-axis stage creates accurate 3D construction of detailed height information and extended depth composition. The 3D analysis software is pre-installed for further advanced analysis. Rotary head provides 360-degree rotation of the mirror, which enables the side of the object to be thoroughly observed. Hirox Page Reply 1 card # 38

That’s another problem solved Find out more about how the extraordinary Rocket Evaporator can do the work of six rotary evaporators by going to www.genevac.com/movie/rocket

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PITTCON 2010

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rc 40 SPECTROPHOTOMETER HAS 5NM OPTICAL RESOLUTION Instrument measures both reflected and transmitted colour as well as transmission haze. In addition, it meets CIE, ASTM and USP guidelines for accurate colour measurement. The instrument’s 5nm optical resolution enables it to precisely measure colours with sharp cutoff characteristics. Its D65 illumination source is calibrated in both the ultraviolet and visible regions for the accurate measurement of whitening agents and fluorescent colours. Having an extended measurement range, into both the near infrared and near ultraviolet, permits the measurement of camouflage materials and UV blockers. It also features three sizes of sample measurement areas with automated lens change. HunterLab Reply card # 40

SENSORS ELIMINATE TRANSMITTERS FOR PROCESS CONTROL Sensor system for pH, dissolved oxygen and conductivity measurements is designed with entirely new technology. Each sensor features a built-in microprocessor that can communicate with both analog (4-20 mA) and digital modbus interfaces. Direct connectivity eliminates the need to send data through costly transmitters and manufacturer says the signals are more robust and reliable than the low currents or voltages produced in classical measurement systems. The sensors can be precalibrated and configured right in the lab, reducing costs associated with installation and downtime. Hamilton Company Reply card # 41

rc 43 SENSORS DELIVER ACCURATE DETECTION FOR CHALLENGING FLUIDS Available in two model series, capacitive liquid level sensors offer a level-sensing solution for many bottle types, including plastic, glass and fibreglass. The compact sensors are suited for medical applications such as waste, reagent or diluent liquids as well as dark, sticky or viscous fluids. Easy to calibrate, both sensor series are available for OEM orders. One model is a non-contact sensor that mounts to exterior of non-metallic tanks and bottles with wall thicknesses up to 5/8-in thick. The other model mounts via a threaded 1/2-in NPT boss in either metallic or plastic vessels. Gems Sensors Reply card # 42

rc 41 KNIFE MILL IS DESIGNED FOR FOOD SAMPLES The sample preparation of foodstuffs is expedited with this knife mill. With a capacity of 4.5 litres and a 1.1 kW motor, the mill quickly and efficiently homogenizes samples with high water, oil or fat content. Its special knife design and variety of grinding chambers allows for the homogenization of large quantities of frozen french fries, pizza and gummy candies. It features simple and convenient operation and cleaning. The grinding chamber and knife are easily attached and removed without the use of tools. In addition, all components that come in contact with the sample are removable and autoclavable. Retsch Reply card # 44

MICRO GC IS FAST AND SMART

COLUMN TECHNOLOGY DELIVERS UHPLC ON ANY HPLC

Gas chromatograph (GC) is designed to be faster, smaller, smarter, easier, and greener than traditional GCs. The flexible and versatile general-purpose GC is based on a platform suitable for laboratory, at-line, online and field use. The new micro model is configured for gas and/or liquid samples from methane up to n-C44 in boiling point equivalence, making it suitable for simulated distillation: gasoline range organics up to end boiling points of about 450 °C. Excellent hydrocarbon speciation is made possible with a range of relatively non-polar, mid and high polarity and specialty column modules using fast program temperature profiles to maximize separations and measurement capability. Falcon Analytical Systems & Technology Reply card # 43

Ultra-high-performance liquid-chromatography (UHPLC) column is based on the company’s new core-shell silica technology and is designed to improve results and increase productivity without large capital expenditures. By delivering significant improvements in speed and separation efficiency over traditional 3- and 5-micron columns, the column enables chromatographers to get performance comparable to sub-2-micron columns without investing in UHPLC systems, according to the manufacturer. As a result, the manufacturer says researchers can achieve UHPLC results on any LC instrument platform, and any chromatographic method can be completed at a fraction of the time previously required, without sacrificing performance. Phenomenex Reply card # 45

TRENDS IN MICROSCOPY

LAB PRODUCT NEWS • 04/10 • labcanada.com

IR spectroscopy in the

BY KEVIN KJOLLER, CRAIG PRATER & ROSHAN SHETTY, ANASYS INSTRUMENTS, SANTA BARBARA, CA

NANOSCALE I

nfrared nanospectroscopy is a novel technique that enables scientists and engineers to map chemical composition on previously inaccessible length scales. For many years, infrared spectroscopy has provided the ability to characterize and identify chemical species. However, it has always been restricted to spatial resolution in the order of 5-10 microns and then only when applying attenuated total reflection spectroscopy. Now, when combined with the nanoscale spatial resolution of an atomic force microscope (AFM) tip, it is possible to measure and map local chemical composition below the diffraction limit of light. The technology will also perform nanoscale topographic, mechanical and thermal analyses. The technology is provided through a new platform called nanoIR™, a probebased measurement tool that reveals the chemical composition of samples at the nanoscale (figure 1). This laboratory solution combines key elements of both infrared spectroscopy and atomic force microscopy (AFM) to enable the acquisition of infrared spectra at spatial resolutions of 50-200 nanometers, well beyond the optical diffraction limit. Potential application areas span polymer science, materials science, and life science, including detailed studies of structure-property correlations. The science behind the system applies the patent-pending technology of photothermal induced resonance (PTIR), a technique pioneered by award-winning researcher Dr Alexandre Dazzi of the Laboratoire de Chimie Physique, CLIO, Université Paris-Sud, Orsay, France. The nanoIR system uses a pulsed, tunable IR source to excite molecular absorption in a sample that has been mounted on a ZnSe prism (figures 2 and 3). Samples are prepared in one of two ways. For many samples, ultramicrotomy is used to cut sections with thicknesses between 100 nm and 1000 nm. These are then transferred to the prism surface. In other sample prepara-

FIGURE 1: The Anasys nanoIR system displaying a topographic image of a PET/polyamide composite.

This laboratory solution combines key elements of both infrared spectroscopy and atomic force microscopy. tions, it is possible to cast thin films from solvent directly on the prism. The IR beam illuminates the sample by total internal reflection similar to conventional ATR spectroscopy. As the sample absorbs radiation, it heats up, leading to rapid thermal expansion that excites resonant oscillations of the cantilever which is detected using the standard AFM photodiode measurement system. These induced oscillations decay in a characteristic ringdown which can be analyzed via Fourier techniques to extract the amplitudes and frequencies of the oscillations. Then, measuring the amplitudes of the cantilever oscillation as a function of the source wavelength, local absorption spectra are created. The oscillation frequencies of the ringdown are also related to the mechanical stiffness of the sample. With maximum flexibility, the IR source can also be tuned to a single wavelength to simultaneously

map surface topography, mechanical properties, and IR absorption in selected absorption bands. The ability to combine nanoscale spatial resolution with chemical spectroscopy provides users with the tools to quickly survey regions of a sample via AFM and then rapidly acquire high-resolution chemical spectra at selected regions on the sample. Making additional mechanical and thermal properties measurements with nanoscale resolution adds significantly to the power of the technique. The system enables researchers to harness the full power of mid-IR spectro scopy. The IR source is continuously tunable from 3600 to 1200 cm-1. This range covers a major portion of the mid-IR, including important CH, NH, and CO bands, as well as carbonyl and amide I/II bands. Polymer spectra acquired with the system have demonstrated good correlation with bulk FTIR spectra. The software also allows researchers to export nanoscale IR absorption spectra to standard analysis packages (eg, Bio-Rad’s KnowItAll®) to analyze samples and identify chemical components rapidly. The software also allows integrated thermal and mechanical property map-

TRENDS IN MICROSCOPY

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FIGURE 2: Schematics to illustrate how the nanoIR works

FIGURE 4: The multifunctional measurement capability of the nanoIR

sis was also performed on the same sample clearly identifying softening at different temperatures for the nylon and EAA layers. FIGURE 3: Sample mounted on ZnSe prism

ping in addition to its ability to provide high-resolution infrared spectra. Mechanical properties of a sample can be collected using a contact resonance method to map stiffness variations simultaneously with the topography. The platform can also perform nanoscale thermal analysis, allowing researchers to work beyond bulk thermal analysis measurement to obtain information not otherwise available. Figure 4 shows a very clear example of the technique. This figure illustrates topographic (A), spectroscopic (B), mechanical (C) and thermal (D) data sets from a composite sample of nylon and ethylene acrylic acetate. The mechanical and spectroscopic data was obtained simultaneously, thus allowing direct correlation of mechanical stiffness information with chemical composition data. Note that the transitions in contact stiffness correlate extremely well with the strength of the CH absorption. Nanothermal analy-

Applications developments Applying PTIR in the nanoIR system combines infrared spectroscopy and atomic force microscopy to provide high resolution topographic, chemical, mechanical and thermal mapping. This combination provides spatial resolution at length scales well below the diffraction limit of conventional IR spectroscopy and adds

chemical spectroscopy to the field of atomic force microscopy. The potential for future applications is very broad and includes polymer blends, multilayer films and laminates. In the life sciences, sub cellular spectroscopy and the study of tissue morphology/histology will be eagerly awaited while in materials science, prospects are good for the study of organic photovoltaics and defect analysis. Anasys Instruments LABPN Reply card # 15

ENERGY-EFFICIENT MICROSCOPE HAS 10-YEAR LAMP LIFE Ergonomically designed LED microscope system offers easy handling, ultra-long-life illumination and robust capabilities. The microscope is designed for use by medical and veterinary students, new doctors and professionals working in small laboratories, provides durable, quality performance and allows for up to 10 years or more of daily use before a lamp change is necessary. The microscope can be set up in minutes, and arrives complete with everything needed to begin imaging using brightfield illumination. It delivers crisp, bright images, and darkfield imaging is available with the addition of a darkfield stop. Olympus Reply card # 53

TRENDS IN MICROSCOPY

LAB PRODUCT NEWS • 04/10 • labcanada.com

SYSTEM COMBINES HIGH LASER POWER AND REPETITION RATES Laser microdissection tool can distinguish between relevant and non-relevant cells and tissues. It gives forensic DNA technologists the ability to selectively and routinely analyze microscopic regions of interest down to a single cell to obtain results and make determinations that are relevant, reproducible, and specific. The system’s laser beam movement is controlled by high-precision optics, while the microscope stage and the sample are both fixed. This allows precise cutting accuracy at high magnifications, as well as high cutting speed at low magnifications. Both are prerequisites to obtain homogeneous material for downstream analysis and reliable results. Leica Microsystems Reply card # 54

NEW MODELS EXTEND RAMAN MICROSCOPE LINE Several new microscope versions have been added to the manufacturer’s modular Raman microscope line. A new baseline micro Raman system offers single-point spectrum acquisitions and depth profiling. Another model is equipped with a stepper motor and allows Raman mapping experiments and large area investigations. The stepper motor can also be attached to another model, providing a flexible and powerful research tool for automated large area and high-resolution 3D chemical imaging. A further model features cost-effective high-resolution confocal Raman mapping for high spectral flexibility (UV-VIS-NIR). WITec Reply card # 55

POLARIZATION MICROSCOPE IS MODULAR With minimal effort, six different versions of microscope can be specifically and economically configured for polarization techniques. Within this modular system, each user can configure or research the system by analyzing the requirement and application. Two upper parts of the microscope stand have been developed for polarization, allowing a total of three lower parts and seven upper parts to be available. Designed for use in universities and colleges, research institutes in the fields of geosciences and mineralogy and in the exploration industry, the microscope offers both functionality and flexibility. Carl Zeiss Reply card # 56

MICROSCOPE SEES BIOLOGICAL SAMPLES IN ATMOSPHERE Correlative microscopy tool combines a high-end light microscope (LM) with a high-resolution atmospheric scanning electron microscope (ASEM). The instrument enables observation of samples in their native state, significantly reducing sample preparation time and allowing dynamic observation of real-time processes. The atmospheric SEM allows high-resolution

observation of wet biological samples such as cultured cells and imaging of materials samples in liquids. The system’s specimen dish makes it possible to add reagents, drugs, and other substances to the sample in order to perform experiments and observe reactions in both liquid and gas environments. JEOL Reply card # 57

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labcanada.com • 04/10 • LAB PRODUCT NEWS

BY CHRIS HEIL, THERMO FISHER SCIENTIFIC, MADISON, WI

Nutraceutical ingredient identification with Abstract

Dietary supplements are commonly used to provide necessary nutrients that are not consumed in sufficient quantity in a person’s diet. Nevertheless, dietary supplements may pose a risk to human health if they are not properly used. Current Good Manufacturing Practice (cGMP) regulations for dietary supplements are enforced in the United States to safeguard public health. These regulations require 100% identity testing of the ingredients used in the production of dietary supplements. FT-NIR addresses the requirements of this type of analysis in a fast, accurate and cost-effective manner. This article provides an overview of current regulations and discusses the use of FT-NIR for nutraceutical ingredient identification in dietary supplements. An experiment is outlined to further highlight the benefits of the method.

FT-NIR

Introduction

Regulatory framework

The US Congress has defined the term “dietary supplement” in the Dietary Supplement Health and Education Act (DSHEA) of 1994. According to this definition1, a dietary supplement is a product taken by mouth that contains a dietary ingredient intended to supplement the diet. Some dietary supplements can provide an adequate dietary intake of essential nutrients. However, taking such substances may also involve health risks2. Many supplements contain active ingredients that have strong biological effects in the body, making them unsafe to use. Combining supplements or using them in conjunction with medications could result in harmful, even life-threatening, consequences. It is also dangerous to substitute supplements for prescription medicines or to take too much of them. In response, legislation related to dietary supplements has been introduced by the US Food and Drug Administration (FDA) to promote and protect public health.

In recent years, the US FDA has brought companies that manufacture, package, label or hold dietary supplements under cGMP regulations. By June 2010, all companies, regardless of size, must be compliant with the cGMP’s detailed in the 21 CFR 111 guidance3. The rule establishes the minimum cGMPs necessary to ensure that companies that engage themselves in activities related to manufacturing, packaging, labeling or holding dietary supplements, do so in a manner that does not adulterate or misbrand these products. The provisions of the regulation require manufacturers to evaluate the identity, purity, quality, strength and composition of their dietary supplements. Further to the quality control system, dietary supplement manufacturers must also have all aspects of their process documented in order to show how the results from identification testing were generated and to be able to pass an FDA audit of their facility. A key requirement of the cGMP regulation is to perform 100% identity testing of the ingredients used in the production of dietary supplements. Most dietary supplement manufacturers have over 100 ingredients that need to be positively identified prior to release to production in order to meet cGMP requirements. Fourier transform near-infrared (FT-NIR) spectroscopy is an ideal technique for this type of analysis.

FT-NIR benefits Dietary supplement manufacturers have traditionally used HP-TLC, HPLC and/ or microscopy to perform identification testing of ingredients. However, these techniques create significant time, cost and labour burdens on a manufacturing facility and it is common that more than one of these methods must be used

LAB PRODUCT NEWS • 04/10 • labcanada.com

to conclusively identify a received ingredient. In addition, these techniques require sample preparation and, in the case of microscopy and thin layer chromatography, they can be subjective and involve multiple steps which can result in operator error influencing the outcome of the analysis. FT-NIR spectroscopy is rapid, non-destructive and requires no sample preparation, consumables or solvents. Using this technique saves money and hands-on analysis time and increases testing capacity. Other important benefits of using FT-NIR for ingredient identification include the ability to perform analysis in the receiving warehouse and the ease of instrument and software operation which allows even non-technical personnel to perform identification testing. Table 1 summarizes FT-NIR advantages over other technologies for ingredient identification testing. A library method was developed to demonstrate the suitability of FT-NIR for precise, fast and dependable identification testing of dietary ingredients.

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displayed is the next closest class along with the Mahalanobis distance to that class. Additionally, discriminant analysis was used to determine if all compounds could be accurately classified using one model. If the model would have shown any misclassified standards for a class, then more spectra would need to be added to the method for that class, or refinement of the chemometric model would need to be performed.

TABLE 1: FT-NIR advantages over other technologies for ingredient identification testing.

Experimental A nutraceutical ingredient library, containing 65 compounds with multiple standards for each compound, was developed using an FT-NIR analyzer (Antaris™ II FT-NIR, Thermo Fisher Scientific) and a raw material fibre optic probe (SabIR™, Thermo Fisher Scientific). The probe allowed for easy sampling of solid or liquid ingredients directly inside the original container, through packaging materials or in sampling containers. The multiple standards for each compound were collected by varying the pressure and orientation of the probe to the sample. This built-in variation resulted in a more robust library method that could be more easily and quickly implemented. The compounds in the library were grouped into several sub-categories including amino acids, vitamins, minerals and herbals. The spectral collection parameters were 32 co-averaged scans, 4 cm-1 resolution and spectral collection of 10,000-4000 cm-1. Standard normal variate (SNV) path-length treatment was applied to negate baseline shifts in the spectra caused by differences in particle size and the physical state within and between compounds in the library. SNV normalized the method standards to the same baseline scale. A discriminant analysis method for ingredient identification was developed using a chemometric software package (TQ Analyst, Thermo Fisher Scientific). A total of 17 principal components were used to explain 99.4% of the spectral variation in the library standards. The results provided by the discriminant analysis method include the class identification of the unknown and the distance from the centre of the identified (closest) class to the unknown in Mahalanobis distance units. Other information that is often

TABLE 2: Summary of average distances of each identified and the next closest class. A comparison of the identified class to next closest class distances indicates how well the model can distinguish the different classes. Larger differences indicate that the identified class is spectrally dissimilar to the next closest class. For this library, all samples were correctly identified.

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Results and discussion For the amino acid standards definitive separation was observed based on amino acid compound in a scores plot of PC1 vs. PC2 (Figure 1). The plot also showed that the intra-class separation was very small and there was no overlap between the different classes. Only three amino acid compounds did not show significant separation, namely leucine, isoleucine and methionine. These three amino acids are chemically very similar to each other which results in a more challenging discrimination. However, PC3 vs. PC4 scores plot revealed satisfactory discrimination of these amino acids (Figure 2). The method developed for the 65 nutraceutical ingredients showed good distinguishing power between the different classes (Table 2). In addition, method transfer between two FT-NIR analyzers with raw material fibre optic probes was successfully accomplished. This was highlighted by the amino acid standards collected. One standard for each class of amino acid was analyzed as an independent validation sample on both the master and host FT-NIR. For all 13 amino acid validation samples, proper classification was achieved on both instruments. The difference in distance values was very small (Table 3).

TABLE 3: Class identifications for 13 independent validation samples analyzed on a master Antaris FT-NIR used to build the method and a host Antaris FT-NIR used to test method transferability. All 13 amino acids are identified correctly by both the master and host Antaris with very similar class ID distances and distances to next closest class between instruments proving successful method transfer.

Conclusion Recent US FDA regulations require dietary supplement manufacturers, labellers and packagers of all sizes to meet cGMP requirements. One key aspect of these requirements is 100% identity testing of ingredients used in the production of dietary supplements. FT-NIR spectroscopy is a proven technology for ingredient identification based on its many years of use in the pharmaceutical industry. The technique offers many advantages over other methods including speed of analysis and the ability to analyze directly through packaging materials while also requiring no sample preparation, consumables or solvents. In addition, NIR testing requires less operator time and fewer supplies resulting in direct cost savings. LABPN

FIGURE 1: Principal Component 1 vs. 2 scores plot showing distinct separation of amino acids in the nutraceutical ingredient library.

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References 1 US Food and Drug Administration, Overview of Dietary Supplements, http://www.fda.gov/Food/DietarySupplements/ConsumerInformation/ucm110417.htm 2 US Food and Drug Administration, Dietary Supplements: What You Need to Know, http://www.fda.gov/Food/ResourcesForYou/Consumers/ucm109760.htm 3 Chapter I, Food and Drug Administration, Department of Health and Human Services, Subchapter B, Food for Human Consumption, Part 111, Current Good Manufacturing Practice in Manufacturing, Packaging, Labeling, or Holding Operations for Dietary Supplements, http://ecfr.gpoaccess.gov/cgi/t/text/ text-idx?c=ecfr&tpl=/ecfrbrowse/Title21/21cfr111_main_02.tpl

FIGURE 2: Principal Component (PC) 3 vs. 4 scores plot showing clear discrimination of the 3 amino acids that were the least separated in the PC 1 vs. PC 2 scores plot.

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LAB PRODUCT NEWS • 04/10 • labcanada.com

INSPECTION FLASHLIGHT RUNS 90 MINUTES BETWEEN CHARGES Cordless, rechargeable true UV-A (365 nm) LED inspection flashlight is suitable for photoactivation and UV-A dosing. The instrument uses special LED technology to produce a nominal steadystate UV-A intensity of up to 50,000 µW/cm² at a distance of 15 cm. Powered by a rechargeable NiMH battery, it provides 90 minutes of continuous inspection time between charges. The LED lifetime is 30,000 hours. It is extremely lightweight and compact, weighing just 335 g. Ergonomically designed to provide comfort and freedom of movement during inspections, it has a corrosionresistant anodized lamp body. Spectronics Reply card # 60

ULTRALOW-TEMPERATURE FREEZERS ARE ENERGY EFFICIENT Improved compressor and cooling systems enable ultralow-temperature freezers to provide significant energy savings. The units efficiently combine refrigeration, control, alarm, monitoring and accessibility for product safety at -86°C. Suitable for material storage in medical research facilities, repositories, hospitals, and clinics, the freezers are designed to offer maximum storage volume in the smallest possible footprint for long-term storage of stem cells, cord blood, T-cells, engineered tissue, organ/ tissue, vaccines, bone marrow, hybridomas, lymphocytes, cancer cells, clinical specimens, fibroblasts and other life science samples. SANYO Reply card # 61

ECCENTRIC PUMPS ARE SUPER SMALL With outside dimensions of 13 x 22 x 32 mm, eccentric diaphragm pumps permit the construction of miniature gas analysis devices. Further applications can be found in breath analysis, spirometry or with portable respirators. Despite their small size, the 15.5 gram precision pumps are powerful, offering 900 ml/min free flow, 560 mbar pressure or 600 mbar vacuum. They also consume minimal power, so portable device battery packs can also be significantly reduced in size. The pumps use the manufacturer’s proprietary high-response valve technology, which overcomes performance limitations that can be experienced in miniaturizing valves. For extended service life, high-quality double ball bearing skew wound or brushless dc motors are available. Schwarzer Precision Reply card # 62

REMOTE COMMUNICATION FOR TEMPERATURE CONTROL Low-volume hydraulically sealed thermostats cover temperatures from -120 to 425°C with cooling powers from 450 watts at 0°C up to 24 kW at -60°C and 2 kW at -100°C. They now offer users the option of communication via intranets and the internet, allowing organization of complex temperature profiles and file process data via USB interfaces. In addition users can now communicate with the thermostats using a ordinary mobile phone by Bluetooth or internet interface. Peter Huber Kältemaschinenbau ReplyLPNAug07BH1100MottLab card # 63 8/13/07 4:38 PM Page 1

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PUMPS

MEET DEMANDING NEEDS OF SYNCHROTRON D

ESY (Deutsches Elektronen-Synchrotron) is the largest German research centre for basic research in the natural sciences, with special emphasis on accelerators, photon science and particle physics. The centre develops, runs and uses accelerators and detectors for photon science and particle physics. The PETRA storage ring at DESY has been upgraded to the third-generation synchrotron radiation source PETRA III (PETRA III Project), with 14 beamlines operating under ultra-high-vacuum (UHV) conditions. The vacuum specification requires a hydrocarbon-free vacuum system and the acceptance of vibrations arising from the pumping system is very low. For these reasons, ion pumps are used to

Images: Above: Scroll pump used in the mobile pumping stations. Top right: DESY site, with the PETRA III storage ring hall in the foreground. (Source: DESY)

pump down the beamline continuously. As the start pressure of ion pumps is below 10-6 mbar, mobile pumping stations are used for the initial pump down of the UHV system. Once the UHV state is achieved and the ion pumps switched on, the mobile pumping

stations are turned off. When the new photon beamline system was being planned, a specialized design was required for the mobile dry pumping station with scroll pumps. The DESY team approached Edwards during this design phase because they were already using the manufacturer’s scroll pumps for a number of applications within the research centre. They chose the company’s XDS10 scroll pumps to provide quick rouging and pump down, enabling them to establish high vacuum within the photon beamlines and the experimental stations of beamline users.

an ultimate vacuum of 7 x 10-2 mbar. Pumping begins with the fore pump only working and the valve connecting the system to the turbo molecular pump closed. When both sides are high vacuum, the main valve in the system opens, the UHV pump is activated and the fore pump is switched off. A buffer switch then allows toggling so that the fore pump is automatically restarted as needed. This toggling system means that the fore pump runs for less than five percent of the overall pumping time, which extends maintenance intervals and increases lifetime.

Mobile pumping station design

Benefits of dry pumps

As the mobile pumping stations can be used whenever a dry and particlefree vacuum is required, the stations will also be provided to beamline users to pump down their experimental chambers. The stations additionally give the users the options of leak detection, residual gas analysis and control of their bake-out systems. The new mobile dry pumping station designed by the DESY team to meet these requirements uses two pumps, with the fore pump providing a bypass of the turbo molecular pump to enable rapid pump down of the attached vacuum chamber. “The fore pump is a dry pump – the Edwards XDS10 scroll pump,” says Frank Wagner, Edwards’ key account manager, Scientific Deutschland Nord. “This was ideal for DESY’s requirements because it delivers sufficiently low pressure combined with good pumping speed to create the fast pump down of the system.” The XDS10 offers a high volume flow rate of up to 10m3/hr and creates

The DESY team chose to use dry pumps in their design because they provide a number of important benefits. Dry pumps have no lubricants under vacuum, eliminating the need for regular oil changes and hence reducing maintenance and environmental impact. This also means there is no possibility of process contamination, vital for use in the synchrotron. Edwards XDS pumps use a bearing shield to isolate the vacuum environment from all forms of lubricant, making it not only totally dry but hermetically sealed. The shield also protects the bearing from any process vapours, preventing the possibility of contamination in any direction. Adjustable gas ballast allows vapours to be handled and opens up the range of applications to include many that were previously unsuited to scroll pumps. “Every single component of our mobile dry pumping stations was chosen to ensure the highest performance,” says M Hesse, DESY. “The Edwards pumps play a key role in these stations, and they have delivered exactly what we required.” LABPN Reply card # 17

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LAB PRODUCT NEWS • 04/10 • labcanada.com

INSTRUMENT ENABLES PRESSURIZED CHEMICAL REACTIONS Stirred reactors perform pressurized chemical reactions in the lab. They range in size from 50 ml to 4 litres and may be operated up to 10,000 psi and 350°C. The reactors have a magnetically coupled impeller for optimal mixing. All high-pressure components are ASME rated and protected by a rupture disk for safe operation. The laboratory bench-top models are suitable for applications where repetitive use makes convenience a necessity, such as catalytic studies, polymerization, hydrogenation, oxidation, isomerization, and dehydrogenation. The compact instruments fit easily into a fume hood. Supercritical Fluid Technologies Reply card # 64

AGITATOR BEAD MILLS IN THREE LAB-SIZED MODELS Designed for wet grinding of small batches, agitator bead mills accommodate different grinding chambers that vary in fabrication and size for specific applications. The mills can grind particles down to 10 to 20 nanometres in size. The complete line comprises three mills, each with grinding chamber parts fabricated for specific applications. One model is designed for metal-free grinding and solvent-based applications, featuring chamber parts in wear-resistant zirconium oxide. A general-purpose model is made of stainless steel and has a cooled chamber. The third model uses polyurethane parts for grinding water-based products. NETZSCH Fine Particle Technology Reply card # 65

DIGITAL FORCE GAUGE IS ECONOMICAL Loaded with features at an economical price, digital force gauge has a large, easy-to-read, high-resolution dot matrix LCD. The instrument supports a variety of standard gauge functions including normal and peak readings. It is available in seven ranges from 2 to 500 lb force and features a measurement accuracy of greater than 0.25% full scale. Loads are displayed in ozf, gf, lbf, kgf and Newtons, and the display language may be set-up to indicate in English, Spanish, French and other languages. The high-accuracy, CE-compliant product is battery operated and includes a NIST calibration certificate. Omega Reply card # 66

ANALYZER IS COMPACT, POWERFUL, RELIABLE

CHROMATOGRAPHY SYSTEM OFFERS HIGHER PRODUCTIVITY New flash purification system is designed for use by pharmaceutical and agribusiness researchers. The system streamlines the purification of new molecular entities and natural products. It is intended for researchers whose higher productivity needs and small sample sizes are not addressed by current flash technology. Productivity gains are realized through the integration of the manufacturer’s detection technology and enhanced system software. Advanced optimization features within the software speed separation and deliver efficient separation guidance needed by discovery scientist. Grace Davison Discovery Sciences Reply card # 67

Benchtop NMR analyzer is designed for determining the oil content of seeds, food, wax, and rubber. A compact size minimizes the footprint on critical laboratory benchtop workspace. It also includes a space-saving internal computer with operator interface, so no external PC is required. With the recent change to a 17-in LCD flat screen monitor mounted on the magnet, the user is provided with a clear view of data and operational instructions. New test and diagnostic software makes remote servicing of the instrument a costsaving convenience. The instrument’s permanent magnet is a small size and has a very high homogeneity. Oxford Instruments Reply card # 68

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labcanada.com • 04/10 • LAB PRODUCT NEWS

CIRCULATING WATER BATHS ARE ERGONOMIC, EFFICIENT New line of circulating water baths is lab and operator friendly. Featuring temperature ranges from -40° to +200°C, temperature stabilities to ±0.005°C, the units are available with six temperature controllers, including two programmable models. Both refrigerating/heating and heat-only baths are available. The baths include ergonomic features such as a swiveling control head that permits viewing of the temperature display anywhere within a 180° radius. An integral lid docking system provides no-mess reservoir cover storage, and a corrosion/chemical resistant top plate dampens noise and remains cooler at high temperatures. PolyScience Reply card # 69

MAILERS SAFELY CATALOGUE, STORE AND SHIP SPECIMENS Micro-slide boxes enable users to safely catalogue, store, and ship specimen slides. The boxes include colour-coded slide folders for separating slides by subject, date, or department; rigid cardboard mailing boxes with slotted foam inserts and wire tabs that protrude through the top, bend over and can be taped for tamper-evident packaging; and plastic boxes. Suited for use in a wide range of laboratories, the slide boxes come in standard sizes and styles for holding up to 100 slides each and can be custom imprinted, labelled, and developed to match customer requirements. Mason Box Reply card # 70

SCANNER PERFORMS OPEN AIR SURFACE ANALYSIS Designed for rapid chemical analysis of surfaces, scanner is interfaced to the manufacturer’s DART®-SVP open-air ionization source. The device enables rapid mass spectrometry analysis of chemicals on surfaces such as food, packaging materials, fabrics, consumer products, electrical components, and wafers. Automated surface analysis can be accomplished without placing the sample under high vacuum as in traditional surface analysis. The Apple® iPod-based controller directs the analysis of the entire surface for uniformity or allows the user to choose specific locations, thus enabling rapid characterization of contaminants with no sample preparation. IonSense Reply card # 72

BALANCE HAS ENERGY EFFICIENT POWER SUPPLIES SYSTEM OPTIMIZES SOLVENT CONCENTRATION OR REMOVAL

A lighter, smaller and more efficient power supply makes this balance fully energy efficient. The manufacturer says the durable and easy-to-use balance is suitable for every laboratory weighing need. A new high-quality robust metal housing offers reliable protection and is resistant to chemicals. A redesigned user interface allows for intuitive operation, with smart keys to offer direct access to preferred applications. Highcontrast display provides error-free reading of results and enhances the user friendliness of the balance. Built-in shock and overload protection assure a long product life. Mettler Toledo Reply card # 73

MICRO-GLOSS GLOSS METERS HAVE BLUETOOTH® New microgloss gloss meters have improved continuous and difference modes and transfer data with a USB cable interface or wireless with Bluetooth®. The micro-gloss family still has features including ergonomic and easyhandling design, multilingual display with simple-to-navigate menu, longterm, stable calibration with an automatic check of the calibration standard, several modes for basic to statistical measurements, measurement range of up to 2,000 gloss units, and temperature stable data. BYK-Gardner USA Reply card # 74

A new accessory extends the sampling versatility of the manufacturer’s evaporator to accommodate up to 18 accelerated solvent extractor tubes simultaneously. This addition makes the system suitable for environmental, food and agricultural scientists who commonly employ solvent extraction techniques and require concentration of extracted samples prior to analysis. Using special low-temperature, lowpressure steam heating technology, the evaporator can provide fast evaporation with precise temperature control, thereby accelerating the safe concentration of extraction samples. Evaporation of the tubes is fast, safe and provides good recoveries of even the most volatile analytes. Genevac Reply card # 71

SYSTEM OPTIMIZES COMPLEX SAMPLE PREP Third-generation core module automation system is designed to optimize workflow integration. It enables scientists to leverage a single automated platform to run a diverse array of laboratory applications, and gives scientists a configurable system for preparing, processing and testing intricate samples including biologic formulations, biomass samples, and other complex mixtures. The platform offers an extensive list of new features such as a larger deck, an automated tool changer, off-deck access with robotic arms, and a balance and imaging module that accommodates vials, bottles, jars, and plates. Freeslate Reply card # 75

CLINICAL & LIFE SCIENCES

Map of Germany, with Thuringia (Thuringen) highlighted in grey ellipse. Far left: The main building of Friedrich Schiller University, in Jena.

Trends & Innovations IN MEDICAL TECHNOLOGY

t a recent workshop organized by the German Chamber of Commerce in Toronto, a delegation from the German Free State of Thuringia discussed trends and innovations in medical technology. Thuringia is a hotbed of innovation and commercialization by private companies, research institutes and universities. Many of these organizations have a strong focus on collaboration, and are actively seeking worldwide partners. The event kicked off with the signing of an agreement for cooperation between the Ontario Photonics Industry Network and OptoNet, an optics cluster in Thuringia (see news story, page 8). The first workshop presenter was Dr Ulrich Simon, president and CEO of Carl Zeiss Microimaging, who spoke about current trends in life science research. The expected world population growth from 6 billion today to 10 billion by 2050 and exponential growth of the 65+ age group offers both challenges and opportunities for the medical technology industry. The opportunities will come from a focus on sickness prevention, increasing quality of life and lessening the stress on healthcare systems. The challenges come from exploding healthcare costs – for example, German healthcare costs have doubled in the past decade – a decline in the number of medical professionals, practices and hospitals merging and causing a decline in demand for purchasing medical technologies. Innovation by research, industry and healthcare professionals must address these economic realities and drivers, he said. Thuringia has a long tradition of bringing together the various stakeholders, with particular strengths in the medical technology, biotechnology and pharmaceutical areas. Starting with glass and precision technologies in the 19th century, the area is now home to 200 companies that are medical instrument manufacturers, plus 110 companies in the biotech and pharma research areas. In addition, several universities including the Friedrich Schiller University Jena are located there – the latter alone has 9 clinics and institutes in the fields of biotechnology and pharmacy. The state also has 14 other non-university research institutes, 7 business-related research institutes, 10 R&D service centres, and 7 founder centres. Some of the medical technology companies there include Carl Zeiss MicroImaging, which produces microscopes systems for

biomed research, clinical and industrial applications; Carl Zeiss Meditec, which produces medical, lasers, diagnostic / therapeutic systems; Analytik Jena, which produces analytical / bioanalytical instruments; CyBio, which makes lab systems for high-throughput screening; Bauerfeind; which makes surgical hoses and bandages; Jenoptik, which produces laser beam sources, optical systems and components; and Trumpf Medizin Systeme, which makes operating table systems. Dr Simon pointed to optical technologies in particular as an

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CLINICAL & LIFE SCIENCES

(Continued from page 27) important cross-technology player in a number of areas, including cell- and molecular biology, early diagnostics, drug development, preventive medicine, improved minimal invasive therapies, and personalized medicine. He pointed to product developments in each area from his own company as examples of the innovative medical technology research being done, such as 3D live cell microscopy on a molecular level and immuno-histochemic staining for molecular diagnostics. Prof Dr Andreas Tünnermann, director of the Fraunhofer Institute for Applied Op-

labcanada.com • 04/10 • LAB PRODUCT NEWS

tics and Precision Engineering in Jena, says his institute focuses on optical technologies which he says is key to future innovation. Along with his organization, 162 companies in Thuringia work in the photonics area, and it is the home to an innovation cluster for optical technologies called Jena Optical Innovations (JOIN). He provided an example of cooperative research being done there to treat presbyopia in a process similar to LASIK. Rounding out the discussion on innovative medical technology in Thuringia, Dr Peter Miethe, CEO of the FZMB Research Centre of Medical Technology and Biotech-

nology, outlined how the private, non-profit research centre focuses its activities on arthritis and cartilage regeneration as well as point-of-care (POC) diagnostics and food safety testing. In particular, the institute’s researchers have developed an immunofiltration assay for use in POC tests as well as all the essential components for the systems, including filters, analytes, columns and portable read-out systems. Similar products are under development for food safety testing, and in all the areas, the company is interested in finding partners to undertake collaborative projects. LABPN

WEST NILE VIRUS ANTIBODIES Five new antibodies of monoclonal antibodies to West Nile virus are all specific to the viral envelope glycoprotein (E). They function in ELISA, IFA and cross reactivities to other flaviviruses which can be found on the data sheet at www.virostat-inc.com. West Nile virus (WNV) is an insectborne virus that first appeared in North America in 1999. Since then it has spread steadily throughout the continent. This member of the flaviviruses infects animals including birds and horses as well as humans. Most human infections are asymptomatic, however some can result in serious neuroinvasive complications such as encephalitis. ViroStat Reply card # 80

WELDABLE TUBING FOR BIOPHARMACEUTICAL APPLICATIONS High-quality, weldable tube is designed to produce a connector-free fluid path that is quick, easy and secure. Capable of completely secure welding, it allows for connector-free fluid paths to be assembled in minutes. A low internal spallation allows the tube to remain pristine, making it very economical. Made of thermoplastic elastomer, the tubing contains no animal-derived components that could leach into precious duty fluids. With a high level of purity and clarity, it is suitable for use in sanitary environments in pharmaceutical and biotechnology processing applications. Watson-Marlow Pumps Reply card # 81

NEW KITS ARE FOR NUCLEIC ACID-BASED DIAGNOSTICS Over 30 new kits for nucleic-acid based diagnostics target human pathogens such as: HPV, HIV, HSV-1 & 2, HBV, Chlamydia, gonorrhea; food-borne pathogens such as: Listeria, Salmonella, Streptococcus species, and plant pathogens such as: Plum Pox Virus (PPV), Aspergillus, Penicillium, and Boytritis. The kits are based on non-invasive sample preparation, and include all the components for isolating high-quality inhibitor-free NA, as well as master mixes and controls to allow for PCR amplification and detection. The kits combine both sensitivity and specificity of detection, and include controls. Currently for research use only. Norgen Biotek Reply card # 87

INSTRUMENTS HANDLE SMALL TISSUE PROCESSING Flexible small tissue processing instruments are for clinical, life science and microbiology applications. Capable of processing samples from 250µL to 80mL, the range caters to the increased demand for smaller samples, without reducing sample quality to ensure maximal visible cell recovery. The instruments also offer 5000-fold improvement in cell recovery and viability from traditional methods, diluent-free sample processing, no cross contamination between samples, adjustable processing time and paddle speed, a 3-year warranty and 10-year service support. Seward Reply card # 83

CLINICAL & LIFE SCIENCES

LAB PRODUCT NEWS • 04/10 • labcanada.com

CLINICAL CHEMICAL ANALYZER NOW DOES DIABETES TESTING Compact, semi-automated, clinical chemistry analyzer is for routine and specialized diagnostic testing and now includes HbA1c for routine monitoring of diabetic or at-risk people. The new test offers specificity, precision and sensitivity. As a tough and reliable system, the analyzer requires little maintenance and is suited to a variety of settings including clinical laboratories, specialized clinics, research laboratories and in food and wine testing. The comprehensive test menu includes routine clinical chemistry, cardiac, lipids, diabetes, antioxidants, renal function, liver function, electrolytes, veterinary testing and food and wine testing. Randox Laboratories Reply card # 85

UV STERILIZATION CABINET FOR PCR WORK Sterilization cabinet is designed for molecular biology labs that are carrying out polymerase chain reactions (PCR). The cabinet provides decontamination of reagents and equipment before carrying out sensitive PCR reactions, particularly when amplifying DNA sequences which are either in limited supply or of low copy number. Four timercontrolled 15-watt UV bulbs enable the user to control the exposure time and dose of high energy UV irradiation required to denature nucleic acids that cause unwanted background contamination. Scie-Plas Reply card # 84

GROWTH FACTOR KITS OFFER MULTIPLE ANALYTE DETECTION Human EGF, HGF, PDGF-BB and VEGF-A can be detected simultaneously from 25 µl of serum, plasma, or cell culture supernatants. The products can be used on most available flow cytometers. Analysis software is easy to use and comes complimentary with each order. Bender MedSystems Reply card # 94

FLOW CYTOMETER HANDLES LARGE PARTICLES Particle flow cytometer can analyze, sort and dispense objects that are too large or too fragile for traditional flow cytometers. The instrument offers interchangeable flow cells to handle a 10-1,500 micron size range. Typical samples include small multicellular model organisms, delicate large cells/cell clusters, seeds and beads. Samples are analyzed one by one in a continuously flowing stream and can be sorted based on size, optical density and up to four fluorescent parameters. Using special soft-touch air-jet diverter technology, the instrument can sort and dispense even fragile samples like adipocytes while maintaining their viability. Union Biometrica Reply card # 82

KINASE ARRAY DESIGNED FOR DRUG SCREENING Protein kinase microarray includes 200 recombinant human protein kinases for screening. The microarray has wide utility including applications for drug target counter screening, to identify novel kinase substrates, establish kinase antibody specificities, and for the discovery and testing of protein kinase-protein and protein kinase-compound interactions. With these new kinase microarray services, clients can inexpensively assay the abilities of their lead compounds to inhibit any of the 200 different protein kinases for as low as $1.65 per kinase with triplicate measurements. Industry standards for these types of measurements typically cost $4-5 per kinase tracked, according to the manufacturer. Kinexus Reply card # 88

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CLINICAL & LIFE SCIENCES

labcanada.com • 04/10 • LAB PRODUCT NEWS

PLATFORM SAVES TIME AND MONEY FOR CLINICAL TRIALS Fully configurable platform allows users to design and deploy clinical trial integrated response technology (IRT) systems, and can save 40 percent on the development time of clinical trials. The platform provides pre-validated programs so developers do not have to spend valuable time re-configuring studies. For some studies, the platform will deliver a validated study program in just four weeks rather than eight weeks. Clinical program managers have more control to perform mid-study changes on the fly. The pre-validated programs allow clinical trials to move ahead more rapidly because project managers do not have to rely on custom development for each change. Endpoint Reply card # 89

SMART CUVETTES ENABLE NONINTRUSIVE pH MONITORING Optical pH sensing cuvettes turn spectrophotometers into drift-free pH meters. A sol gel coating material encapsulates pH indicator dyes into coatings applied to the cuvettes, allowing the manufacturer’s miniature fibre optic spectrometers and accessories to be used for optical pH sensing of 5.0-9.0 pH range samples. The readings can be taken quickly and accurately using existing spectrometer setups, negating the need for a dedicated pH meter. Unlike traditional pH electrode meters, the cuvettes can be used for monitoring low conductivity samples such as boiler water. Ocean Optics Reply card # 86

CLINICAL ANALYZER HANDLES COMPLEX ASSAY PROTOCOLS Multidisciplinary analyzer provides flexibility for creating unlimited complex assay protocols in clinical chemistry and coagulation, and in quantitative and qualitative ELISA. It includes microplate or strips reaction support and a flexible spectrophotometer optical system (340-700 nm). With realtime reaction curves and handling linear and nonlinear calibrations, the instrument also has quality control allowing graphical representation of performance and automatic statistics calculation. It is dedicated to haemostasis analyses for chronometric, chromogenic and turbidimetric tests. Features low reagent consumption and uses low-cost microtiter plates as reaction support. Maxmat Reply card # 90

SPECTROPHOTOMETER IS EASY TO USE

PIPETTE TIP REFILL SYSTEM IN 17 STYLES Tip refill system offers a complete refilling solution for laboratory pipetting procedures. Refills are available in 17 different tip styles to accommodate use with all brands of pipettors. With a focus on environmentally friendly construction, each refill is a complete system with a low carbon footprint. Packaging is constructed from 95% renewable material, all recyclable portions are clearly coded, and tip bases include the use of bioplastic (non-petroleum) compostable resin. VWR Reply card # 92

Designed for the rapid and accurate quantification of nucleic acids and protein samples, spectrophotometer can measure volumes as low as 0.5μl due to a “drop and measure” sample plate and does not require cuvettes or capillaries. The plate has enhanced compatibility with many chemicals and sample types and is hydrophobic which enables easy sample recovery and cleaning. Built-in software provides a user-friendly interface, with convenient drop-down lists that include methods for measuring common fluors. Researchers can also choose from a wide range of storage methods and data output options. GE Healthcare Reply card # 91

Advertisers’ Index RC#

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114................Buchi Corporation................. 13 115.................Genevac.................................. 15 116................Goodfellow . ..........................19 150................Goodfellow............................. 31 117................Mottlab...................................23 151.................Mottlab................................... 31 113.................Nuaire.......................................7

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152................Nuaire..................................... 31 112................Omega Engineering................3 153................Omega Engineering.............. 31 119................Pickering Laboratories.......... 29 154................Pickering Laboratories........... 31 118................Retsch.....................................27 155.................Retsch..................................... 31

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Company

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156................Sanyo Biomedical.................. 31 120................Sanyo Biomedical............. OBC 111.................Thermo Fisher Scientific.....IFC Also in this issue: ESBE brochure and Mottlab product card

TECHNICAL LITERATURE

LAB PRODUCT NEWS • 04/10 • labcanada.com

LABORATORY LITERATURE REVIEWS ULTRA-HIGH-PURITY PRECIOUS METALS IN A RANGE OF FORMS

Goodfellow offers ultra-high-purity precious metals — gold, silver, platinum, palladium, rhodium, ruthenium, iridium and osmium — in small quantities for research and product design. They are available in a wide range of forms including foil, wire, rod, tube, mesh, sputtering target, powder, lump and single crystal.* The company can also supply both standard and custom alloys. www.goodfellow.com *Not all metals are available in all forms.

GOODFELLOW

NEW LINE OF WOOD LAB CASEWORK FROM MOTTLAB Mottlab’s great, new line of wood lab casework offers a wide range of sustainability options, extensive custom options and very competitive pricing. This product can be seamlessly integrated with our fume hoods and mobile lab solutions. For more information visit: www.mottlab.com. MOTTLAB Circle Reply Card no. 151

Circle Reply Card No. 150

POLYPROPYLENE FUME HOODS NuAire’s Polypropylene Fume Hoods provide quality personnel protection; excellent choice for long lasting, highly corrosive resistant, metal free applications; ideal solution for professionals in chemical engineering, environmental toxic analysis, analytical chemistry, and trace metal analysis fields. www.nuaire.com NUAIRE INC. Circle Reply Card No. 152

TEMPERATURE MEASUREMENT HANDBOOK® AND ENCYCLOPEDIA VOLUME MMXIV 7th EDITION

Omega’s New Temperature Measurement Handbook® 7th Edition offers detailed information and specifications on over 40,000 products. It contains the latest technology in sanitary temperature sensors and devices, wireless connectors and instruments, profile temperature labels, thermal imagers and infrared temperature products, and automation products. www.omega.ca/literature/7thedition OMEGA ENGINEERING, INC.

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PINNACLE PCX AMINO ACID ANALYSIS WITH TEMPERATURE GRADIENT The Pinnacle PCX HPLC Post-column Derivatization system was created for analysis of Amino Acid, Carbamate, Mycotoxin, Antibiotics and other applications. Each component is specifically designed for post column analysis to optimize the sensitivity and selectivity of your analysis. www.pickeringlabs.com PICKERING LABORATORIES

RETSCH CUTTING MILL SM 300 The new Heavy Duty Cutting Mill SM 300 grinds difficult samples to an analytical fineness in one working run. Its high torque, variable speed drive allows for exceptionally effective preliminary size reduction of heterogeneous mixtures such as bone, plastics or electronic components. www.retsch-us.com RETSCH, INC. Circle Reply Card No. 155

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SANYO INTRODUCES THE TWIN GUARD SERIES™, WITH DUAL° COOL TECHNOLOGY SANYO introduces the MDF-U500VXC -86°C Ultralow Temperature Freezer, the first US model with Dual° Cool technology. Unlike traditional systems, Dual° Cool operates two refrigeration systems with two individual compressors purpose-built to operate independently upon the unusual event of unexpected failure. http://us.sanyo.com/biomedical SANYO Circle Reply Card No. 156

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