Pink Science Spring 2012

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PINKSCIENCE BREAST CANCER CAMPAIGN MAGAZINE / SPRING 2012

GIRLS V BOYS Challenge your friends to raise funds for women and men with breast cancer

PINK TUTUS AND BIG BRAS

How you got involved with Breast Cancer Awareness Month

FIRST FELLOW

Looking back over five years of pioneering research

A WHOLE NEW YOU

Change your life and help save lives

PLUS

Fabulous gift ideas, your letters, pink pictures and more

The pace of living WHY EVERY STEP YOU TAKE HELPS IN THE RACE TO FIND A CURE FOR BREAST CANCER

GET TO KNOW US OUR MISSION

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TOGETHER, WE WILL FIND A CURE Welcome to the spring issue of Pink Science, where we look at the many achievements of last October’s Breast Cancer Awareness Month, as well as the ongoing work we’re doing to find a cure for breast cancer. This year is set to be a busy one for Breast Cancer Campaign – we’ll be launching a new five-year research strategy shortly, and our groundbreaking initiative, the Tissue Bank, has entered a new phase with much-needed tissue now being made available to all breast cancer scientists in the UK and Ireland. Turn to page 19 to read more about one researcher who’s benefiting from the Tissue Bank. We aim to fund world-class research and support the best scientists in the field. Our first Campaign fellow, Dr Rob Clarke, is an excellent example, and you can find out more about his successes over the past five years on page 16. We couldn’t fund this vital research without your support. With spring coming soon, there are lots of ways you can make a difference – see page 12 for inspiration on how you can BE PART OF THE CURE, and do tell us how you get on.

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Baroness Delyth Morgan Chief Executive, Breast Cancer Campaign

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N OT E B O OK BREAST CANCER CAMPAIGN NEWS FROM AROUND THE UK

Annual celebrations

HAVING A BALL FOR SCIENCE The stars came out for Breast Cancer Campaign

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PAINT THE TOWN PINK

Our fantastic volunteers turned towns and cities pink for Breast Cancer Awareness Month

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Doing your bit

RAGS TO RICHES Students hit the capital’s streets in the ultimate university challenge

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BUSTING THE WORLD RECORD

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BRIGHT PINK AND BREAST AWARE

Across the nation people wore as much pink as possible to raise money for Campaign. Here are some of our wear it pink highlights

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IT STARTS AT THE TOP

Breast Cancer Campaign is committed to raising the profile of breast cancer research in British politics. Here’s a quick round-up of our latest activity

POLITICIANS WEAR IT PINK FOR CAMPAIGN

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Survey results

GETTING OLD IS GREATEST RISK

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The bigger picture

70 Women over 70 are most at risk of developing breast cancer but very few check themselves regularly

53% Just over half of women aged over 70 are aware that they can request an appointment to continue to be screened

15,000 A third of all breast cancer diagnoses every year are in women aged 70 or older – over 15,000 cases

50-70 Women aged between 50 and 70 years old are invited to attend an NHS breast screening every three years

THE HEALTH BILL Baroness Morgan debates the new Bill in the House of Lords

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RESEARCHING THE CURE

READING THE SIGNALS Dr Keith Brennan at the University of Manchester has been funded by Campaign since 2002

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Supporting innovative science

MAKE A CHANGE FOR LIFE From giving up coffee to taking on a challenge, there are plenty of ways to make a difference. Take inspiration from these great fundraising ideas

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MAKE A SMALL CHANGE

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GIVE UP AN HOUR Help out and volunteer with a local group

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GIRLS VS BOYS

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REACHING THEIR PEAK $QG\ OHIW $QJHOD LQ SLQN FDS DQG IHOORZ FOLPEHUV

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Reach the heights to raise funds for Campaign

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Getting to the root of the problem DR ROB CLARKE HAS MADE GROUND-BREAKING DISCOVERIES THANKS TO HIS CAMPAIGN FELLOWSHIP

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t Breast Cancer Campaign, we cells in a breast tumour, it’s thought they fail DUH IXOO\ FRPPLWWHG WR ÂżQGLQJ D to kill the CSCs, which then continue to divide, cure for the disease. There’s still forming a new breast tumour. so much to discover about how ‘It’s like leaving the roots of a weed behind,’ and why cancers develop, and explains Dr Clarke. ‘By not destroying it, you VFLHQWLÂżF UHVHDUFK LV YLWDOO\ LPSRUWDQW increase the chances of the plant growing back. The charity has been supporting research for This evasion of breast cancer treatments by 23 years and has given more than ÂŁ37 million CSCs may explain why the disease returns in grants. However, there has been growing in around 30 per cent of people.’ concern that scientists are leaving medical 7KDQNV WR 'U &ODUNHÂśV FXWWLQJ HGJH UHVHDUFK research, and we realised more needed to be we now have a better understanding of how done to ensure they were able to research breast CSCs work and interact, which is crucial in cancer full time. So in 2006 we ÂżQGLQJ ZD\V WR HUDGLFDWH WKHP ,Q LQWURGXFHG RXU 6FLHQWLÂżF )HOORZVKLS particular, his research has focused 7KH ÂżYH \HDU JUDQW RI on a molecule called Notch, which he LV DZDUGHG WR XS DQG FRPLQJ LGHQWLÂżHG LQ DV EHLQJ LPSRUWDQW I HOPE MY scientists to help them develop into in controlling breast cancer stem cells. RESEARCH ZRUOG FODVV LQGHSHQGHQW EUHDVW In recent years, scientists have WILL LEAD TO developed drugs that block the activity cancer researchers. 7KH ÂżUVW RI WKHVH SUHVWLJLRXV TREATMENTS of the Notch molecule, and these grants was awarded to Dr Rob Notch inhibitors are currently being THAT WILL Clarke of the Paterson Institute in clinical trials in the US. STOP BREAST tested at the University of Manchester It is hoped they will be able to treat CANCER to investigate breast cancer stem tumours by destroying the cancer RETURNING stem cell ‘roots’, opening up more cells. Believed to be key players in the disease returning in nearly a treatment options and saving many third of patients, making progress in thousands of lives. discovering more about stem cells The guaranteed funding provided seemed a perfect place to start. by the fellowship has given Dr Clarke the time And Dr Clarke, who completed his fellowship to apply for grants to support a team of highly in September last year, has made some skilled researchers, as well as train students VSHFWDFXODU DGYDQFHV LQ KLV VSHFLDOLVW ÂżHOG who will become the next generation of Researchers already knew that the breast breast cancer scientists. It has also given contains many different types of cells, all him the opportunity to meet and share new thought to have come from a single type of discoveries with experts around the world. breast cell known as a stem cell. These stem Îź%HLQJ D %UHDVW &DQFHU &DPSDLJQ )HOORZ KDV cells are unique as they are always present, been fantastic, and I’m honoured to have been and continue to divide to produce other types WKH ÂżUVW Âś VD\V 'U &ODUNH Îź7KHUHÂśV EHHQ KDUG of breast cells required over a lifetime. work and the excitement of new challenges, Scientists believe breast cancer originates people and places. I’ve learnt a lot and hope IURP VWHP FHOOV FDOOHG FDQFHU LQLWLDWLQJ VWHP that my continuing research will lead to new cells (CSCs). While current treatments kill the treatments that will stop breast cancer returning.’

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Photography: Michael Thomas Jones

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The path of progress 1914

John S Dexter noticed a notch in WKH ZLQJV RI WKH IUXLW À\ FDXVHG by a mutated Notch gene

1980

Research shows a role for the Notch gene in breast cancer in mice

1998

US researchers discover breast stem cells that can grow new tissue when transplanted between mice

2000

Dr Rob Clarke chooses the Notch gene as his research speciality

2003

US researchers discover breast cancer stem cells, thought to be a source of cancer cells in breast tumours

2006

Dr Clarke is awarded Breast &DQFHU &DPSDLJQÂśV ÂżUVW HYHU 6FLHQWLÂżF )HOORZVKLS

2011

Dr Clarke shows that the Notch gene regulates breast cancer stem cells

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K AN B 0 6 [ B R E A SU TE AWA R E S E ] S I T DAT UP

Deryn with great niece Iris Edwards Finnegan BELOW: with friends Sue Pepper and Louise Buckle

THE GIFT OF LIFE After Deryn Howard discovered she had breast cancer, she donated her tissue to research via our new Tissue Bank

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eryn Howard was taking a shower when she felt a lump in her left breast. Both her grandmothers, her mother and her aunt had breast cancer, so she went to her GP immediately. The lump was mobile, so it could have been nothing, but because of her family history Deryn’s GP arranged for it to be checked out. A month later she went to a clinic at Barts and the London hospital, BREASTCANCERCAMPAIGN.ORG

where she was given a mammogram, an XOWUDVRXQG D ¿QH QHHGOH aspiration (biopsy), and D VDPSOH RI ÀXLG ZDV taken from two areas of her breast. When the test results came back Deryn found out she had cancerous cells in her breast and her surgeon recommended a mastectomy, removal of the nipple and immediate reconstruction. Before the operation, Dr Sally Smith, one of the researchers at the Breast Cancer Campaign Tissue Bank at Barts, asked her if she’d be happy to donate her breast tissue to the Tissue Bank. Sally explained that using the tissue in this way wouldn’t affect her diagnosis or treatment, and that only tissue that wasn’t needed for her treatment would be stored.

Deryn was happy to donate her affected breast tissue. Ο, KDYH VL[ QLHFHV DQG D JUHDW niece, so I hope that donating tissue will help future generations of women like me,’ she says. Since opening in February last year, the Breast Cancer Campaign Tissue Bank has collected samples from over 1,000 people. From January 2012 the tissue will be available to all breast cancer researchers, whatever their location or funding stream. You can see Deryn tell her story in a video on our website at breastcancertissuebank.org

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STUDY SHOWS BREAST CANCER ON THE RISE – IN MEN Around 340 men in the UK develop breast cancer each year – how aware are you?

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ew research reveals that the number of cases of male breast cancer in the UK is increasing. Dr Valerie Speirs at the University of Leeds led the study, which reviewed hundreds of male breast cancer cases in England, Scotland, Canada and Australia. Each year around 340 men are diagnosed with the disease, and around 70 of them will die. Dr Speirs

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THE INCIDENCE OF BREAST CANCER IN MEN IS RISING

study, funded by Campaign and Yorkshire Cancer Research, has given new impetus to scientists studying male breast cancer. Our Tissue Bank is collecting and storing samples of male breast tissue, which are invaluable to researchers working to understand the disease. Dr Speirs now plans to focus on examining the genes and proteins involved in male breast cancer to determine whether there are similarities or differences with female breast cancer. This may highlight JHQGHU VSHFLÂżF GLIIHUHQFHV WKDW can be exploited to improve and develop treatments targeted at men. ‘While cases of male breast cancer are increasing, it must be stressed that the numbers are still small – 150 times less than in women,’ says Dr Speirs. ‘But men need to be more aware of the risks as early diagnosis increases the chances of survival.’

discovered that in England the incidence of male breast cancer increased from 185 cases in 1986 to 277 cases in 2006. Pinpointing an exact cause IRU WKLV LQFUHDVH LV GLI¿FXOW according to Dr Speirs. Lifestyle changes over the past few decades have led to increased obesity, physical inactivity and the GHYHORSPHQW RI D ELQJH drinking culture, which could all be contributing factors. Some of the same inherited genetic changes that increase the risk of women developing the disease are also thought WR LQÀXHQFH WKH ULVN LQ PHQ Due to the relatively small number of cases of men with the disease, UHVHDUFK KDV EHHQ GLI¿FXOW Most of the information INVALUABLE used to diagnose and treat The Tissue Bank is vital to Dr Valerie men comes from studies Speirs’ research of female breast cancer, but data from this new

MALE BREAST CANCER IN NUMBERS

47,700 women in the UK are diagnosed with breast cancer each year

340 men in the UK are diagnosed with breast cancer each year

70 men in the UK die from the disease each year

33% increase in male breast cancer cases in England over a 20-year period

Symptoms to look out for‌ If you discover discharge from the nipple that may be blood stained, swelling of the breast, a sore or ulcer in the skin of the breast, a nipple that is pulled or retracted into the breast or a lump under the arm, contact your GP straight away.

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“

At 22 miles, I remember everything my wife’s gone through, and I know what I feel is nothing in comparison – it’s a great motivator

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WORDS Johanna Derry PHOTOGRAPHY Michael Thomas Jones BREASTCANCERCAMPAIGN.ORG

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Pounding pavements and pathways week after week, Kevin Hunt and Pat Walkington are just two of the incredible people who run to raise money for Breast Cancer Campaign. Pink Science went to meet them to find out what motivates them to go the extra mile

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YOUR POINT OF VIEW

We love getting your letters, questions and stories. Here’s a pick of our favourites. Write to us and you could win one of our fabulous pink products‌ YOUR FACEBOOK COMMENTS

STAR LETTER GIFT FOR THE FUTURE

Q

I’m thinking about leaving Campaign a gift in my will but I’m unsure of what can be left to a charity. Can you leave valuable items as well as money? Iris Singer, via email

A

A gift of any kind can be left in your will, and we are always incredibly grateful for all gifts left to us by supporters. Always seek advice from a solicitor when writing or updating your will, but whether you leave

D VSHFL¿F DPRXQW LWHPV RI YDOXH or a residuary gift of what is left after your friends and family have been taken care of, we’ll ensure we use your gift to fund world-class, life-saving breast cancer research. Congratulations Iris! Your star letter wins you this stylish Coral cutlery set from Viners worth £60

Last issue we featured Emma Parlons, who discovered she had the BRCA1 gene mutation and decided to have a double mastectomy and her ovaries removed. Here are some of your messages on Facebook‌

ANIMAL FRIENDLY?

FEELING LEFT OUT

Do you think using animals for research is still necessary? Yvonne Williams, Newcastle

Why is your website so pink and female focused? Men get breast cancer and are affected by the disease too. Robert Johnson, Norwich

Q A

Campaign acknowledges that despite developments in areas such as cell culture and computer modelling, some research still depends on the use of animals. This isn’t an issue we or our scientists take lightly. All new medicines, no matter what they are, are required by law to be tested on animals. Campaign supports the Association of Medical Research Charities (AMRC) position on the use of animals, and will not fund animal research unless it is essential and there is no alternative.

Q A

We use the colour pink because of its strong association with the breast cancer cause, but the website is designed to focus on the disease as a whole and the range of people it affects. In all our communications we aim to help people understand that breast cancer affects both women and men. We’re also funding research into male breast cancer – see page 19 for more details.

I know someone who has just been told they have the BRCA1 gene mutation too and they have some hard decisions to make. I hope Emma’s story helps them. Valerie Stimpson I’m glad she talked about breast reconstruction. I’m having that done and it’s been worrying me. Well done for sharing your story, Emma. Michelle White Emma’s story helped me to train hard for my epic cycle ride in India for Campaign in December. You can still donate at justgiving.com/ carolynandjanetgomadinindia Carolyn Hobbs Very good article which helps to clear up any doubts. Thank you.. Rosana Dirkin

WE’D LOVE TO HEAR FROM YOU, SO PLEASE GET IN TOUCH WRITE TO US AT:

CALL US ON:

visit OUR WEBSITE:

TWEET US:

Breast Cancer Campaign, Clifton Centre, 110 Clifton Street, London EC2A 4HT

020 7749 4114

breastcancercampaign.org/ aboutus

@BCCampaign

EMAIL US AT: info@breastcancer campaign.org

FACEBOOK AT: facebook/breast cancercampaign

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