Pink Science Spring 2013

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PINKSCIENCE BREAST CANCER CAMPAIGN MAGAZINE / SPRING 2013

ACTION PACKED

Find out what a fantastic job you did during Breast Cancer Action Month

A LOOK TO THE FUTURE Our researchers have been having their say on the future of breast cancer treatment

BREAST OF MATES

Our regional groups are about more than fundraising, they’re about friendship too

PLUS

All the latest news from the charity, pink products and important dates for your diary

Every step I take brings us closer to the cure THE FUNDS YOU RAISE ARE HELPING US WITH OUR GROUND-BREAKING BREAST CANCER RESEARCH


GET TO KNOW US OUR MISSION

£40 million

Everything we do at Breast Cancer Campaign is focused on one thing: beating breast cancer. The charity is bringing its unique community of supporters, scientists and those touched by breast cancer closer through a new way of thinking: Pink Science. It sums up the charity’s pioneering approach to breast cancer research, which identifies and funds the research projects with the greatest potential to save and improve lives – and, ultimately, find a cure for breast cancer.

Today, the charity supports 95 research projects, with combined funding of more than £16 million, in 34 centres of excellence across the UK and Ireland. All our donations come from the fundraising efforts of people like you – thank you. Over the past 16 years, the charity has awarded 386 grants worth a total of over £40 million to universities,

medical schools and research institutes. And the figures are rising.

UNDERSTANDING PINK SCIENCE We chose a jigsaw piece as our logo because it symbolises the missing piece of the puzzle that is the cure for breast cancer. Everyone can be part of Pink Science; not just the scientists whose work we fund but also our supporters and, of course, those touched by breast cancer.

12,000

women who die from breast cancer every year

80%

of women diagnosed with breast cancer today will still be DOLYH LQ ¿YH \HDUV

1 in 8

chance a woman will get breast cancer in her lifetime

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WHAT DO THE PINK ICONS MEAN? Pink Science covers every aspect of breast cancer research. Its eight themes Prevention mirror the cancer journey, making Pink Science accessible and relevant to all. Treatment

47,700

women diagnosed with breast cancer every year

years between screening invitations for women aged 50 to 70

Emotional

Education

TO FIND OUT MORE PLEASE VISIT OUR WEBSITE BREASTCANCERCAMPAIGN.ORG OR CALL OUR SUPPORTER CARE TEAM ON 020 7749 4114

Biology

Genetics

Diagnosis

Growth

JOIN OUR FACEBOOK GROUP OR FOLLOW US ON TWITTER @BCCAMPAIGN

340

men diagnosed with breast cancer every year – it proves fatal for around 80

Figures relate to UK and are correct at time of going to press

HOW WE SPEND YOUR MONEY

TOTAL WE HAVE AWARDED IN GRANTS TO FUND BREAST CANCER RESEARCH IN THE PAST 16 YEARS

BREAST CANCER FACTS


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Inside this issue 04-09 Notebook A round-up of Breast Cancer Action Month, including wear it pink and the Pink Ribbon Ball. Plus, three ways you showed your support in 2012

10-11

TOGETHER, WE CAN FIND A CURE Welcome to the spring issue of Pink Science. Before we venture into our exciting goals for the New Year, I would like to look back at some of our latest achievements. Thanks to your support, we have invested more than £40 million in vital breast cancer research projects across the UK and Ireland. Our scientists are spearheading research developments, finding ways to treat breast cancer and gaining a better understanding of how to diagnose breast cancer earlier. We select Campaign’s top 10 achievements of 2012 on page 26, which give us hope for the future and will help bring us closer to finding a cure for breast cancer. Hope is definitely a theme of this issue. I hope you enjoy the inspiring story of long-term supporter Jan Casson on pages 20-25, and gain some insight into our second pioneering Gap Analysis meeting on pages 16 and 17. Without your support we would not be where we are today, offering hope through research to those affected by breast cancer. Together we can BE PART OF THE CURE.

Policy We celebrate the Government’s Cancer Radiotherapy Innovation Fund, and introduce our new online breast cancer awareness quiz

12-15 Fundraising friends Meet the supporters who are putting the fun into fundraising and making a difference to Campaign with their friends

16-19 Research Dr Sue Eccles explains why Gap Analysis is vital for breast cancer research. And we present three Campaign-funded VFLHQWLVWV¶ QHZ ¿QGLQJV

20-25 Every step counts Read the inspiring story of Jan Casson, who has dedicated her time to raising money for Campaign and is determined to continue, despite her own battle with breast cancer

26-31 Pink pages See our top 10 achievements, and browse our fab Pink Picks. Plus, gallery and your letters

Baroness Delyth Morgan Chief Executive, Breast Cancer Campaign

PINK SCIENCE is produced by Northstar (thisisnorthstar.com) for Breast Cancer Campaign. Project Editor Emma Barlow Deputy Project Editor Lisa Paul Designer Pippa Hester Group Project Editor Robin Swithinbank Group Art Director Matt Warner Group Production Editor Andy Tidball Production Manager Helen Craig Managing Director Mark Beazleigh. For Breast Cancer Campaign: 0HGLD 5HODWLRQV 2I¿FHU Isabel Monk


N OT E B O OK BREAST CANCER CAMPAIGN NEWS FROM AROUND THE UK

YOU DID IT!

We called on you to take action during Breast Cancer Action Month to help us raise vital funds and awareness. And you didn’t disappoint!

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rom taking part in wear it pink, to painting the town pink, you took action across the nation to raise funds so we can continue to fund groundbreaking breast cancer research. A huge thank you to all of our ‘superheroes’ who got involved – with your support we can all BE PART OF THE CURE. Last October was especially important as we celebrated the 10th anniversary of wear it pink. Hundreds of thousands of you wore

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pink on October 26, and to date we have received £1.7 million, so we’re on track to achieve our target of £25 million raised over 10 years. Leading beauty brand nails inc. helped us spread the word with its Paint Your Pinkie Pink campaign and special-edition Pinkie Pink polish. Plus, the world’s largest bra, which we unveiled during Breast Cancer Awareness Month 2011, sold to GoldenPalace.com in an auction on eBay and raised £3,601 for breast cancer research.

We have loved seeing pictures of how you got involved – like Paulet High School in Burton on Trent (above). If you still have money to send in, visit wearitpink.co.uk or call us on 0800 107 3104. However you got involved, thank you!

IFE SERVICES DO THEIR BIT. THANK YOU!


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YOUR WEAR IT PINK PICTURES

Check out some of our amazing supporters who took part in wear it pink

YOU’RE OUR HEROES! COLLETT TRANSPORT SERVICES

CLIFFORD JONES TIMBER LTD GET INTO THE SPIRIT

PINK SCIENTISTS!

 m KLH ARCHITECTS REALLY LEAP INTO ACTION

PINK SUPERHEROES TO THE RESCUE AT IFE SERVICES

any of our scientists took part in wear it pink, but some took es it to a whole new level. Dr Jam Flanagan, a Breast Cancer Campaign Fellow at Imperial College London, and his team Kirsty Flower, Kevin Brennan and Angela Wilson dyed their hair pink after raising £1,705. Elsewhere, our scientists at the University of Birmingham helped turn the university’s iconic clock tower pink in support of Campaign.

IN THE PINK Sugababe Heidi Range and Dr James Flanagan (below left)

THANKS TO OUR PARTNERS

A

PINK IS SO YOUR COLOUR! LYMINGTON YACHT CLUB

huge thank you to staff at Veolia Environmental Services, Jigsaw, RBS/Natwest, Ladbrokes, Curves, BonmarchĂŠ and nails inc. for helping us to make this the most successful Breast Cancer Action Month yet. Staff at Debenhams held dance events nationwide and took part in a fundraiser DW WKH KHDG RIÂżFH WR UDLVH

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LONDON GOES PINK TO LAUNCH BREAST CANCER ACTION MONTH All over the capital, buildings, towers and other famous landmarks were turned pink to kick-start the beginning of Breast Cancer Action Month for Campaign

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e kicked off Breast Cancer Action Month in style on October 1, when many of London’s most famous landmarks turned pink for Breast Cancer Campaign. Among the iconic buildings in the pink were Buckingham Palace, Somerset House, the Tower of London, BT Tower, and Tower 42, where the launch party was held. 8S RQ WKH QG ÀRRU JXHVWV VLSSHG pink cocktails specially created by Levi Roots as they watched the skyline change colour. Supporters and passers-by also helped boost awareness by posting photos on Twitter, Facebook and Instagram. Check out our pick of the best photos on our Pinterest page (pinterest.com/bccampaign). Other places in the UK that turned pink

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were the Isle of Wight, Reading, North Tyneside, Newcastle-underLyme, Falmouth, Birstall and York. A huge thank you to our volunteer teams for their hard work, and everyone that took part in pink activities. Together you raised over £80,000! If you’d like to turn your town or city pink this October, visit breastcancercampaign.org


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HAVING A BALL The Pink Ribbon Ball Committee organised another great night Annual celebrations

PINK RIBBON GETS THE BALL ROLLING IÂ

LIGHT IT UP Blushing landmarks included (from top) Northwood House in the Isle of Wight, Buckingham Palace, Trafalgar Square, the Tower of London and HMS Belfast

WœV RI¿FLDO RXU WK DQQXDO Pink Ribbon Ball at London’s Dorchester was the most successful yet! The event raised more than £300,000, which will help us continue funding pioneering breast cancer research and bring us closer WR ¿QGLQJ D FXUH IRU WKH GLVHDVH Guests at the event were treated to a special performance by singer Paloma Faith (right). Breast cancer is a cause very close to Paloma’s heart after her mother beat the disease following a diagnosis ¿YH \HDUV DJR Actress and writer Morwenna Banks was the host for an evening of spectacular circus-themed entertainment, featuring magician Pete Firman, Chicks ’n’ Tricks, who performed magic at people’s

tables, Cirque du Cabaret’s high-kicking can-can dancing troupe, Kittie Kittie Kan Kan, and the fantastic hand-balancing act Vladimir Khan.

BE PART OF THE CURE There’s still plenty of time to help add to our fundraising success. If you’d like to hold your own event for Breast Cancer Campaign, or attend the next Pink Ribbon Ball, visit breastcancercampaign.org

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3 WAYS TO FUNDRAISE FOR CAMPAIGN Last year you showed your support in so many ways – including holding collections and buying our pink products (page 30). Are you ready to do it all again this year? YOU BOUGHT

DAMART 10 YEARS

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On Sunday, September 9 more than 200 of you donned your best pink RXW¿WV DQG KHDGHG WR /RQGRQ¶V Hampstead Heath to take part in the WK *HQHUDWLRQV :DON /RFDO 0(3 0DULQD <DQQDNRXGDNLV DQG ZDON IRXQGHU &KHU\O 6WDNRO NLFNHG WKLQJV RII DQG WKH GD\ ZDV D IDQWDVWLF VXFFHVV UDLVLQJ PRUH WKDQ $ KXJH WKDQN \RX WR WKH ZDON FRPPLWWHH DQG HYHU\RQH ZKR VLJQHG XS DQG SDUWLFLSDWHG

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TICKLED PINK

Asda’s campaign has raised £30 million for breast cancer charities

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sda’s Tickled Pink campaign had another huge year in 2012, and since it launched in 1996 it has raised a whopping £30 million for Breast Cancer Campaign and Breast Cancer Care, with every penny going towards supporting people across the UK affected by breast cancer. Tickled Pink started 2012 with a bang as pop stars including Alexandra Burke and The Saturdays took to the stage at London’s Shepherd’s Bush Empire to entertain the crowds at a fabulous Girls’ Night Out concert. Asda staff and customers also

backed the 16th Tickled Pink campaign, including the Tamworth store which hosted a ‘Carve a Pumpkin’ fundraising class, and an Asda colleague in Ulster who shaved her head to raise vital funds. Breast Cancer Awareness Month also saw brands such as Walkers, Jaffa Cakes, Mr Kipling and Lucozade turn pink. All products were available in Asda stores, with proceeds going to both charities. Meanwhile, George at Asda created a dedicated clothing range which included T-shirts, umbrellas and shoes. Fashion designer Julien Macdonald also designed a special

limited-edition reusable bag – all in support of Tickled Pink. Glamorous celebrities Alexandra Burke, Danielle Lineker, Lacey Turner, Zoe Hardman and Heidi Range (above, from left) took part in the 1950s-inspired Tickled Pink Ladies photoshoot to show their support for the campaign. Breast Cancer Campaign supporter Heidi says: ‘Tickled Pink has raised ÂŁ30 million, which has gone towards supporting those affected by breast cancer and ÂżQGLQJ D FXUH %\ EX\LQJ 7LFNOHG Pink items you know your money is helping to save lives.’

ROTARY CLUBS JOIN THE ÂŁ100 CHALLENGE...

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ur patron Linda Nolan joined Breast Cancer Campaign at two annual Rotary Club conferences in Bournemouth and Galway recently, to encourage Rotary Clubs to take on the ÂŁ100 Challenge. The Challenge is open to

groups and clubs of all types and could not be simpler – we ask you to set a fundraising target of ÂŁ100 or more and ÂżQG D ZD\ WR UHDFK LW 6R IDU groups and clubs taking part in the Challenge over the past eight years have raised an amazing ÂŁ1 million. Linda says: ‘I was honoured to speak at such prestigious events. Research into breast cancer is so important, so I

really hope Rotary Clubs take on the challenge and support Campaign.’

BE PART OF THE CURE 7R ÂżQG RXW KRZ \RX FDQ JHW involved in the ÂŁ100 Challenge, call 020 7749 4114 or email 100challenge@ breastcancercampaign.org

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ADD GIFT AID TO GIVE MORE Breast Cancer Campaign calls for changes to improve access to essential Gift Aid funds

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ear it pink raises millions for Breast Cancer Campaign, but half a million pounds each year is lost because of Gift Aid red tape. Campaign is taking action to change this and calling on the Government to simplify requirements for small workplace donations. In 2011, wear it pink raised over £2.2 million for Campaign but the charity only managed to reclaim £40,000 in Gift Aid. As more than 75 per cent of money raised through wear it pink comes from people giving money in the workplace, this ¿JXUH VKRXOG KDYH EHHQ PRUH than £400,000 – assuming the maximum amount of Gift Aid was reclaimed on all donations. Under current legislation, charities can claim Gift Aid on donations by UK taxpayers when donors

FRPSOHWH D GHFODUDWLRQ FRQ¿UPLQJ their name and address, and that they pay more tax in a year than they donate to charity. However, a survey completed for Campaign by Ipsos Mori revealed that 45 per cent of employees who have made D FDVK GRQDWLRQ KDYH QHYHU ¿OOHG out a Gift Aid declaration. The survey also revealed that 33 per cent of UK workers don’t know anything about Gift Aid. Campaign is now calling for the Government to make changes to raise awareness of the Gift Aid scheme, and also to amend the law to make it easier for charities to access Gift Aid.


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Policy news: spring 2013 IMRT Radiotherapy Breast Cancer Campaign has welcomed the announcement by the Government that they plan to establish the Cancer Radiotherapy Innovation Fund, worth £15 million. The fund is designed to speed up the use of Intensity Modulated Radiotherapy (IMRT), an advanced form of radiotherapy, across the NHS so that more cancer patients can EHQH¿W IURP LW <RXU ZRQGHUIXO VXSSRUW KHOSHG IXQG WKH ¿UVW 8. FOLQLFDO WULDO RI IMRT for breast cancer, and we have been calling for better access to IMRT for a number of years. It’s great that extra money has been made available for its use. According to the Government, designated radiotherapy centres will be providing IMRT from April.

Policy update

SCREENING REVIEW RESULTS An independent review into screening reveals risk of over-diagnosis

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Campaign has developed a brand new breast cancer awareness quiz (above) to help women recognise the signs and symptoms of breast cancer and to get into the habit of checking their breasts on a regular basis. We know that the earlier breast cancer is detected, the better the chances of survival, so please check out the quiz and share it with family and friends by visiting breast FDQFHUFDPSDLJQ RUJ EUHDVWTXL]

BE PART OF THE CURE If you’d like to know more about ZKDW ZH¶UH GRLQJ WR LQÀXHQFH SROLF\ YLVLW EUHDVWFDQFHUFDPSDLJQ RUJ

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Friendship through fundraising

BOSOM BUDDIES From bake sales to climbing mountains – there are lots of ways to support Campaign but it’s always easier when you’ve got a little help from your friends

“It helps that we’re close. We’re also blessed with very supportive friends and family”

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upporting Breast Cancer Campaign is not just about raising essential funds and awareness. It’s also a great way of having fun with your friends, whether you get together to form one of our regional volunteer groups, or team up to do your bit with friends at work. Here, we meet four groups of pals who are fundraising together to BE PART OF THE CURE...

Breast Mates

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udy Baskett and Terry Groom wanted to raise money for Breast Cancer Campaign in memory of their close friend Carol Southgate, who lost her battle with breast cancer aged just 40. Judy (second left) had already been fundraising for Campaign by taking part in the adidas Women’s 5k Challenge in London’s Hyde Park, as well as organising garden parties and holding her popular Tea at Three event in her beach hut in Felixstowe, Suffolk. ‘It was at one of my beach hut SDUWLHV WKDW ZH ÂżUVW GLVFXVVHG IRUPLQJ a volunteer group,’ says Judy. ‘We are all good friends and many of us know someone who has been touched by breast cancer so we were all really enthusiastic about the idea.’ Breast Mates was launched in Stowmarket in 2012, and the group set D IXQGUDLVLQJ JRDO RI IRU WKHLU ÂżUVW year. They have smashed that target – raising ÂŁ4,000 by holding quiz nights, tea parties and a handbag-swapping event, inspired by the Colchester regional volunteer group, Up Front. ‘It helps that we’re close,’ says Judy. ‘Both Terry [far right] and myself have a sister in the group, as well as Terry’s daughter Amy and my best RAISE friend Jane. We’re also blessed VITAL with supportive friends and family. FUNDS ‘We meet up each month to discuss events over a glass of wine – and this year our plans include a Frock Swap, a Sixties Dance and a Pink Dinner,’ says Judy. ‘Being in a regional volunteer group is so rewarding – it’s lovely that we make a difference together. We really are the breast of mates.’ BREASTCANCERCAMPAIGN.ORG


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Ain’t no mountain high enough‌

mma Allard had always wanted to do something for charity. So when her employer, CAA, a small company based in Ipswich, decided to organise a trip to Peru to trek the Inca Trail for charity in 2012, she jumped at the chance. And she encouraged her friend at work, Lori Dunne, to go along too. Together, Emma and Lori were part of a select group chosen to take part in the company trek in support of Breast Cancer Campaign. ‘It was very emotional when we KDG RXU ÂżUVW YLHZ RI 0DFKX 3LFFKX so it was great to have Lori’s

TAKE A CLOSE FRIEND

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support,’ says Emma. ‘We’ve been good friends ever since we met WKURXJK ZRUN DQG LW GHÂżQLWHO\ PDGH it that bit easier knowing that I had a friend I could always turn to. We helped pull each other through the tough parts of the trek.’ Emma and Lori enjoyed the experience so much that they have VLQFH KHOG HYHQWV LQ WKH RIÂżFH together, and to date they have raised over ÂŁ7,000 for Campaign. A bake sale and auction raised ÂŁ200, and their company directors even auctioned their old iPhones to help raise another ÂŁ400.

‘It was a blessing doing the trek for Campaign,’ says Emma. ‘Lori and I had so much fun fundraising together, and it felt special that we got to do something for the inspiring ZRPHQ ZKR ÂżJKW EUHDVW FDQFHU every day with courage and dignity.’

“It made it that bit easier knowing that I had a friend I could always turn to�

PEAK PERFORMANCE Lori (left) and Emma at Machu Picchu in Peru


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Hever Castle Princesses GET YOUR HANDS DIRTY

Working together

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ITIE Group, the strategic outsourcing and energy services company, was already backing the Breast Cancer Campaign Tissue Bank Appeal when Rob Earnshaw from the company decided to sign up 29 of his work friends to go the extra mile and raise vital funds for the charity. After looking at Campaign’s website for fundraising ideas, the colleagues decided to sign up for the Major Series obstacle course, which had all the elements they wanted. It was a physical challenge but they knew it would also be a laugh. And they were right. On October 21, 2012, the group (above) got wet and muddy while smashing their initial fundraising target of £1,450 to raise over £5,000 for Campaign. Rob says: ‘It was so much fun and a great team-building event – and at the same time we raised vital money for an excellent charity and a very worthy cause.’

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arah Lewis-James had been working as Day Visitor Manager at Hever Castle and Gardens in Kent for seven years when she was diagnosed with breast cancer on September 26, 2011. Only the day before she got the news, Sarah had been at the Hever Castle Triathlon, a popular annual event that she helped to organise. ‘I went through two rounds of surgery, followed by radiotherapy,’ recalls Sarah. ‘It was while I was travelling to hospital one morning for my daily treatments that I decided to set myself a goal to work towards. , ZRXOG PDUN WKH ¿UVW DQQLYHUVDU\ RI my diagnosis by taking part in the 2012 Hever Castle Triathlon. ‘I talked to my friends at work, Jane Bradley, Head of Finance, and Anna Spender, Castle Co-ordinator, and they were keen to form a team, with me running and Anna and Jane swimming and cycling respectively.’ And so the Hever Castle Princesses was formed.

SHARE THE WORK

BE PART OF THE CURE If you and your friends would like to do something together to support Campaign, please visit breastcancercampaign.org

Sarah completed her radiotherapy course at the end of January and VWDUWHG WR VORZO\ UHEXLOG KHU ¿WQHVV until she could run 4km. Then, on September 29 last year, Sarah crossed the line of the Anne Boleyn Relay Sprint – part of the Hever Castle Triathlon series – with Anna and Jane at her side and their colleagues cheering them on. The Hever Castle Princesses raised more than £3,700 for Campaign, and not only did they enjoy fundraising together but the experience has made their friendship even stronger. ‘It was such an amazing, emotional day, and I felt a fantastic sense of achievement to complete the course and achieve my goal. But I couldn’t have done it without my wonderful friends who trained so hard with me and were so supportive,’ says Sarah. ‘We wanted to give something back to the women who are dealing with the challenge of breast cancer.’

KEEP ON RUNNING (and cycling and swimming). From left: Sarah, Jane and Anna

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with drugs such as tamoxifen. Then we LGHQWLÂżHG WKH +(5 H[SUHVVLQJ VXEW\SH IRU ZKLFK ZH KDYH WUDVWX]XPDE +RZHYHU WKHUH are many cancers which don’t express these therapeutic targets, and rarer subtypes that remain elusive. We need more types of breast FDQFHU WLVVXH LQ WKH %DQN WR ÂżQG RXW ZKDW drives them and work out how to treat them.’ Access to more tissue samples could also improve our knowledge of therapy-resistant disease and cancers that have spread (metastases), which are responsible for up to 90 per cent of cancer deaths. ‘We still can’t effectively control metastases as they may respond differently from the primary cancer. Treating them is like shooting at an enemy in the dark,’ Dr Eccles explains. DR SUE ECCLES TELLS US ‘Relapse of disease in the liver, bones or WHY CAMPAIGN’S GAP brain is a major challenge to achieving cures. ANALYSIS IS SO IMPORTANT My main wish is to be able to collect more samples of metastatic/drug-resistant cancer FOR THE FUTURE OF BREAST for the Tissue Bank.’ CANCER RESEARCH 7KH VXFFHVV RI ÂżJKWLQJ FDQFHU UHOLHV RQ patients agreeing to donate tissue samples, and if that happens Dr Eccles believes that ive years ago Breast Cancer in 10 years’ time breast cancer treatment will Campaign organised a series of become more personalised. pioneering meetings with the aim of ‘Every patient’s cancer will be genotyped identifying gaps in our understanding and they will be offered a cocktail of drugs of breast cancer. These Gap Analysis WDLORUHG VSHFLÂżFDOO\ WR WKHP ZKLFK VKRXOG OHDG meetings brought together some of the UK and to fewer side effects. Biomarkers will allow us Ireland’s leading breast cancer researchers. to manage their progress so this targeted The most important outcome of their treatment can be altered quickly if it’s ground-breaking talks was the Tissue Bank, ineffective,’ she continues. a unique, innovative and vital tool in the search ‘The hope is that we’ll have found strategic for cures. Scientists now know more about ways to address the gaps in breast cancer breast cancer subtypes than ever before, but research – current and emerging – such as there’s still a long way to go. So last autumn how to deal with the disease in a diverse and Campaign carried out a second Gap Analysis, multicultural society where there could be key and once again gathered a group of experts to genetic differences.’ discuss what more needs to be done. This important ‘The last Gap Analysis was a huge success, initiative enables but it’s important that we carry on highlighting &DPSDLJQ WR UHÂżQH IN 10 YEARS any new gaps so that we can keep breast its cutting-edge CANCER cancer research moving forward,’ says Dr Sue research PATIENTS Eccles, a Campaign Trustee based at The programmes, which Institute of Cancer Research in Sutton who we fund with your WILL BE led the latest round of meetings alongside donations. ‘This OFFERED Professor Alastair Thompson, Chair of the new Gap Analysis DRUGS Tissue Bank Management Board. is a vision for the TAILORED Whatever the new Gap Analysis pinpoints future,’ says Dr in 2013, tissue banking will remain a priority SPECIFICALLY Eccles. ‘That’s for Breast Cancer Campaign. it’s so TO SUIT THEM why Îź:H XVHG WR GHÂżQH EUHDVW FDQFHU VLPSO\ DV important for oestrogen receptor positive or negative,’ she us to continue says. ‘And the former can be treated effectively fundraising.’

A vision for the future

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TISSUE BANK MILESTONES

2011 Breast Cancer Campaign brings together four leading NHS trusts and breast cancer research institutions WR FUHDWH WKH 多UVW UK Breast Cancer Tissue Bank

2012 The Tissue Bank is opened to all breast cancer scientists in the UK and Ireland. The 多UVW WLVVXHV DUH VHQW out in April

2013/14 Tissue banks will begin to collect secondary and rarer types of breast cancer samples, which will have a huge impact on research and could lead to VSHFL多FDOO\ WDLORUHG treatments

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Research update

WE ARE FUNDING THE CURE Breast Cancer Campaign funds some of the UK and Ireland’s leading breast cancer research. Here are some of the latest projects that could save lives one day

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r Jean-Christophe Bourdon is D VFLHQWLÂżF IHOORZ DW 1LQHZHOOV +RVSLWDO 8QLYHUVLW\ RI 'XQGHH +LV ZRUN IRFXVHV RQ WKH NH\ UROH WKDW S LVRIRUPV SURWHLQ YDULDQWV SOD\ LQ EUHDVW FDQFHU

What inspired you to pursue a career in science? During a visit to a hospital for a cancer conference in Paris, I met a doctor, a mother and her terminally ill child in a lift. It was the despair and tears of the dedicated doctor and the most wonderful smile of this very frail child that inspired me to dedicate my life to cancer research, rather than to general medicine. Your work focuses on a protein called p53. Why is it so important? It’s the keystone of our defence system against cancer forming and is inactivated either partially, or totally, in every kind of tumour, including breast cancer. It can be inactivated by mutation or by a virus protein and when p53 stops working, our defence system against cancer formation collapses, so cancer cells are able to grow and spread. How will your work benefit people with breast cancer in the future? I hope we’ll be able to predict the PRVW HI¿FLHQW WUHDWPHQW IRU SDWLHQWV by determining the type of breast cancer they have, the p53 mutation status and which p53 isoforms are expressed in the patient’s breast tumour after they have a biopsy or surgery. So we should be able to improve treatment, as well as avoid unnecessary treatment. We are winning battles against breast cancer and results indicate that we are not far from winning the war.

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How has Breast Cancer Campaign supported your work? Breast Cancer Campaign has played an essential role in my work. In 2006, the charity decided to fund three years of my research project into p53 – it was a unique opportunity so I seized it. Then in 2012, Campaign awarded me its prestigious Fellowship, which will support my research on p53 over WKH QH[W ¿YH \HDUV ,WœV YHU\ reassuring to know that my work will be allowed to develop over that time, despite the current ¿QDQFLDO GLI¿FXOWLHV DQG WKH Government’s cuts in the science budget. I am so grateful to Campaign and everyone who supports this fantastic cause. Dundee has a strong tradition of breast cancer research – what is it like being part of that? I moved from Paris to Dundee LQ MXVW DIWHU , ¿QLVKHG my PhD, to join the research laboratory of eminent cancer scientist Professor Sir David Lane, who actually discovered p53. Although I promised my wife that it would only be for two years, we’re still in Dundee 15 years later! I recently established my own research group on p53 in breast cancer and joined the prestigious Breast Cancer Research team, headed up by Professor Alastair Thompson, Chair of the Tissue Bank Management Board. What is your ultimate goal? I want to provide clinicians with the tools they need to identify and treat each type of breast cancer with minimal side effects, so that in the future our children and grandchildren will not suffer from this terrible disease. We can all do something to help beat breast cancer, so it’s crucial that people continue to fund research. For more on Jean-Christophe, visit breastcancercampaign.org

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Supporting science Three new projects you have helped us fund... Treating drugresistant breast cancer DR RICHARD CLARKSON When the cells in a patient’s breast tumour overproduce oestrogen receptors (ER) they are diagnosed with ER-positive breast cancer. This type of cancer is treated with antihormone therapies such as tamoxifen and fulvestrant. Sadly, about 30 to 40 per cent of patients with ER-positive cancer will become resistant to these drugs, so it’s crucial scientists develop alternatives. At Cardiff University, Dr Richard

Cancer immunotherapy PROFESSOR ANDY SEWELL Radiotherapy and chemotherapy can often result in severe side HIIHFWV VR LWœV YLWDO ZH ¿QG new and effective treatments that will improve the quality of life for patients. One solution could be cancer immunotherapy, a treatment that uses the body’s immune system WR QDWXUDOO\ ¿JKW FDQFHU FHOOV Professor Andy Sewell, who is based at Cardiff University, believes the key lies in a protein found in

Treating breast cancer in older patients Dr Alistair Ring A third of breast cancer cases in the UK are diagnosed in women over the age of 70. However, doctors can currently only make subjective decisions about which treatments to use for older patients, who might have other health problems. Dr Alistair Ring believes that decisions about treatments for older patients could be made more objectively by assessing their ‘biological age’.

Clarkson has found a way to kill the cells that have become resistant to anti-hormone therapies using drugs to activate a protein called the ‘TRAIL’ receptor on the cell’s surface. Dr Clarkson will use his Campaign grant to look at how tumours taken from antihormone resistant patients respond to TRAIL receptor drugs, and will also investigate how a protein called ‘cFlip’ controls the way breast cancer cells respond to these drugs. His research could provide patients with ER-positive breast cancer with further options if their anti-hormone drugs stop working.

breast cancer cells called MAGE-A3. Fragments from this protein, called peptides, would normally cause our immune system’s killer T-cells to attack the cancer cells. However, T-cells have been taught not to attack the body’s cells, including breast cancer. Supported by his Campaign grant, Professor Sewell aims to avoid such ‘self-tolerance’ by stimulating killer T-cells in the lab with ‘super peptides’ made from MAGE-A3. This research could eventually lead to an effective breast cancer immunotherapy.

Using his pilot grant from Campaign, he will take blood from 140 healthy volunteers of various ages and 20 breast cancer patients over 70, and measure a variety of indicators – all believed to correlate with age. The indicators include the length of a piece of DNA called the telomere, the amount of a protein called p16INK4a in blood cells, and the levels of proteins called cytokines. From this study, Dr Ring hopes to develop ways to determine a person’s ‘biological DJHÂś WR ÂżQG WKH PRVW DSSURSULDWH treatment for older patients.

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I know that fundraising will be a part of my life forever. Every step I take brings us closer to finding a cure

WORDS Emma Barlow PHOTOGRAPHY Charlie Campbell

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Jan Casson has had a tough 12 months but she’s still fighting for women with breast cancer

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ithin a matter of weeks, Jan lost her stepmother Rose to advanced breast cancer, received the news that she too had the disease, and then her older sister Cathy was diagnosed with a rare form of leukaemia, which was the result of breast cancer treatment she received seven years ago. For lots of women, this would be too much to bear. But not for Jan. ‘In many other ways 2012 was a good year – with the Olympics and the Queen’s Jubilee celebrations. I just felt so proud to be British!’ Jan says, grinning. It’s this ability to see the positives among the negatives, plus her incredible determination, that has enabled Jan to raise a vast amount for Breast Cancer Campaign over the years. These qualities have also made her a true inspiration for others. Jan, who lives in North Tyneside with her husband Ian and daughter Lori, says she’s lived with breast cancer all her life. 6KH ZDV ZKHQ KHU PXP ZDV ÂżUVW GLDJQRVHG ZLWK WKH GLVHDVH and just 23 when she died. ‘Mum was only 52 and her death left a huge void in my life,’ she says. While Jan eventually came to terms with her loss, the hereditary nature of the disease was always in the back of her mind, and when her older sister Cathy was diagnosed aged 51, Jan thought that one day it would ‘come knocking’ on her door. She decided that if she was going to get the disease, she needed some kind of game plan to prepare herself for it. Îź, ZDQWHG WR EH ÂżW Âś VKH VD\V Îź$QG LW ZDV DOVR about giving myself and Cathy something to focus on. She lives in Holland, so I visited her over there and said: “When you’re sorted, we’ll do some fundraising together.â€?’ It was Cathy who decided they should raise money for Breast Cancer Campaign. Both sisters passionately believe that research holds the key to beating breast cancer. 7KH\ UDQ WKHLU ÂżUVW *UHDW 1RUWK 5XQ IRU WKH FKDULW\ LQ D \HDU DIWHU &DWK\ ÂżQLVKHG KHU WUHDWPHQW Îź, SXOOHG KHU WR WKH ÂżQLVK OLQH RQ WKDW ÂżUVW UDFH %XW ZH ZHQW IURP RQH HYHQW WR WKH next and we did really well,’ says Jan. $IWHU ÂżYH \HDUV DQG QXPHURXV UDFHV &DWK\ decided to hang up her trainers, so Jan was on the lookout for her next challenge.

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‘I thought I’d just up the bar a bit,’ she says. ‘Upping the bar’ meant entering the London Marathon in 2011, and despite developing a stress fracture in her leg – a massive setback to her training – Jan completed the marathon and raised yet more vital funds for Campaign.

fter going it alone for the marathon, Jan decided it would be nice to get together with other Campaign supporters to fundraise. So last summer she helped put together Pink on the Tyne, a regional volunteer group dedicated to raising money for Campaign. In the short time the group has been together, the members have raised a phenomenal £18,000 through events, including walking Hadrian’s Wall and hosting regular Pink Curry Nights – which are a huge hit! In fact, over the seven years since Cathy’s diagnosis, fundraising has become an integral SDUW RI -DQœV JDPH SODQ ¹ DQG KHU OLIH $QG WKH cause became pertinent again when Jan’s


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IT WASN’T A SHOCK BECAUSE I HAD BEEN PREPARING MYSELF FOR BREAST CANCER

stepmother Rose was diagnosed with breast cancer in 2006 and sadly passed away in 2012. Unbelievably, just two weeks after Rose’s death, Jan spotted a dint in her left breast. ‘I went to the GP that day and I said: “I’ve got this problem‌â€? As soon as I said it I realised that I had breast cancer. It was logical that it was going to happen at some stage,’ says Jan. Jan hasn’t been screened for a BRCA mutation – the gene mutation that increases the risk of breast cancer – and Cathy’s test was negative, but she’s convinced that the disease

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UXQV LQ KHU IDPLO\ $QG KHU IHDUV ZHUH FRQÂżUPHG 10 days later when -DQ ZDV RIÂżFLDOO\ GLDJQRVHG with breast cancer. ‘It wasn’t a shock,’ says Jan, ‘because I had been preparing myself for breast cancer. I think my husband, my daughter and my friends got the biggest shock.’ Jan’s cancer was classed as invasive but not aggressive and was contained within the breast tissue. A lumpectomy would have been enough to remove the cancer but Jan elected to have a mastectomy. ‘I was intent on having a mastectomy and I was given a little bit of time to go down another route, which included reconstruction at the same time,’ she explains. The surgeons took away the tumour from within the breast tissue and fortunately found that the lymph nodes were clear of cancer. Then they also inserted an implant. Jan did have to go back into hospital for a further procedure DIWHU D Ă€XLG EXLOG XS EXW RWKHUZLVH WKH VXUJHU\ was a great success. BREASTCANCERCAMPAIGN.ORG


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I CAN’T CONTROL THE DRUGS I TAKE AND I CAN’T CONTROL THE SURGERY I’VE HAD. THE THING I WAS IN CONTROL OF WAS MY HAIR, SO I SHAVED IT OFF

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Campaign’s 2012 achievements Thanks to your support we have made some incredible achievements in 2012. As we move into the New Year we take a look back at some of them... DR JAMES FLANAGAN discovered strong evidence that epigenetic changes in genes can be an indicator of breast cancer risk – many years in advance of breast cancer developing. DR STEWART MARTIN found that the protein calpain-2 could help predict survival outcomes for women with triple negative breast cancer and basal-like breast cancer – the two most aggressive types of breast cancer and the two PRVW GLI¿FXOW WR WUHDW DR FIONA KENNEDY published research exploring how women’s perceptions of a DCIS diagnosis change over time, and made recommendations for information and communication needed in clinical care. EYE-OPENING Dr Fiona Kennedy shed light on DCIS

PROFESSOR ROS CORNEY carried out a study which revealed that young women with breast cancer needed more information and support on fertility issues. RECORD SUPPORT for wear it pink from MPs, MSPs and AMs, including video messages of support from Nick Clegg MP, Ian Duncan-Smith MP, Ed Miliband MP and Ed Balls MP. REPLACEMENT IMPLANTS were granted for all breast cancer patients with PIP implants (as appropriate) after Campaign called on the Department of Health to clarify the rights of breast cancer patients. DR JO MORRIS learnt more about how the BRCA1 gene interacts with other proteins, bringing us closer to the bigger picture of how cancer develops from mutated BRCA1 genes. DR OLIVIA FLETCHER DQG KHU WHDP IRXQG WKH ¿UVW direct link between breast cancer risk and genetically determined levels of oestrogen in younger women.

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GUIDING LIGHTS Professor Ros Corney studied young women with breast cancer. Below: our supporters

BREAST CANCER CAMPAIGN and wear it pink were mentioned in Prime Minister’s Questions in September, which led to the Prime Minister agreeing to meet with the Chairs of the All-Party Parliamentary Group on Breast Cancer and the leading breast cancer charities. SEVEN SCIENTIFIC AWARDS or prizes won by our scientists for their pioneering work in breast cancer research for 2012.


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YOUR POINT OF VIEW

We love it when you get in touch with your letters and questions, or to share your experiences. So here’s a few of our favourites...

I’M NOT A RUNNER! HOW CAN I HELP?

Q

I’m really keen to support your charity but I don’t want to run a marathon or do a trek. Is there anything else I can do? Eva Karlsson-Blyth, Wembley

A

There are lots of ways you can get involved with and support Breast Cancer Campaign. Maybe you feel inspired to organise your own event with your family, friends or colleagues? Start with something small such as a bake sale or clothes swap, or organise a big event such as a black-tie ball! With Valentine’s Day around the corner, why not link your fundraising event to this. For more ideas and inspiration, please visit our website, or call our Supporter Care team (details below).

I’D LIKE TO BE ON YOUR TEAM

Q

I’ve secured a place for this year’s Virgin London Marathon and I’d like to run for you and raise sponsorship to fund breast cancer research. Can I get a pink vest? Stephanie Smith, north London

A

Congratulations on securing your own place! We would really love to have you on our team, and by running for us you will be helping Campaign to beat breast cancer. If you contact our Supporter Care team they will send you a free running and fundraising pack, which includes sponsorship forms and a vest.

WHAT IS MINIMUM SPONSORSHIP?

Q

I want to take part in your Grand Canyon Trek this October. What’s the minimum sponsorship I need to raise? Isabel Good, Cardiff

A

The Grand Canyon Trek is a fantastic and unique challenge and we’d love for you to join us. The registration fee is £399, which goes towards DFFRPPRGDWLRQ IRRG ÀLJKWV DQG transfers, and we ask that you raise a minimum sponsorship of £3,350. Our Fundraising Team is here to help and support you. Call them on 020 7749 4114 for more information and advice.

GET IN TOUCH WRITE TO US AT: Breast Cancer Campaign, Clifton Centre, 110 Clifton Street, London EC2A 4HT

CALL SUPPORTER CARE: 020 7749 4114

EMAIL US AT: info@breastcancercampaign.org

VISIT OUR WEBSITE: breastcancercampaign.org/aboutus

TWEET US: @BCCampaign

FACEBOOK AT: facebook/breast cancercampaign

JOIN IN Share your photos with us on Facebook today!

Request your Campaign moneybox Your spare change can make a real difference, so save it up for Breast Cancer Campaign with a fantastic new moneybox for your home. Instead of having piles of small change lying around, why not pop it in a moneybox instead. Over time, the pennies will add up and you’ll raise vital cash to help us fund world-class and pioneering breast cancer research. To request your moneybox today, please contact us on 020 7749 4114. Raising money for Breast Cancer Campaign has never been simpler! BREASTCANCERCAMPAIGN.ORG


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Breast Cancer Campaign’s latest...

CHARITY STARS A heartfelt thank you to everyone who has been busy fundraising for Campaign. Here is just a selection of what you’ve all been up to

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1 Supporter Alison Brown completed her sixth Great North Run for Campaign – she has raised over £8,000 to date. 2 Soroptimist members took part in a sponsored walk, with personalised pink Mini in tow. 3 At just 19 days old, Sophia Morris was our youngest wear it pink participant. 4 Helen and Eric Sorrell raised almost £8,000 at their second Bridge Champ event. 5 TOPS held a coffee morning and quiz, raising £650. 6 John from Damart and Ikram from Campaign celebrated 10 years of Damart support. 7 34 of our wonderful supporters took part in the Three Peaks Challenge to raise funds for Campaign. 8 Supporter Catherine Drage held a dinner and dance, raising over £4,000. 9 The Breast of Bromley regional volunteer group kicked off their fundraising campaign with a party. 10 Dean, a butcher from Birstall, endured a chest, leg and eyebrow wax to raise £420 for Campaign. 11 Stella Carter trekked the Great Wall of China to raise funds. 12 Amanda Hyde hosted a glamorous ball at Studley Castle, raising over £5,000 for Campaign. BREASTCANCERCAMPAIGN.ORG


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UP-TO-DATE

CHOCOHOLIC

PEN PAL

TEA FOR TWO

Keep track of your social engagements with this cute pink personal organiser from Filofax

This chocolate fountain is perfect for a party and will impress your guests

A splendid partner to the pink Filofax, this liquid gel pen by Pentel is perfect for scribbling in your diary

Ideal for a his and hers morning brew, these pretty mugs by Ethos* will ensure you wake up with a smile – and the perfect cuppa

£30, filofax.co.uk £2 donation to Campaign

£23.99, call 01268 505 090 Ethos* is donating £10,000 to Campaign this year

£2.99, pentel.co.uk 25p donation to Campaign

£2.99, call 01268 505 090

Pink Picks

BAKING QUEEN You too can be a domestic goddess and give Nigella and Delia a run for their money in this heart-print apron by Ethos* £9.99, call 01268 505 090

If you’re looking for the perfect Mother’s Day gift, or simply treating yourself, why not choose one of our fab ‘pink picks’ and a contribution from your purchase will help Campaign fund life-saving research

FOUR SEASONS $GG D OLWWOH ,WDOLDQ ÀDLU to your spaghetti bolognese with this pink pepper grinder from Ethos*. Buon appetito! £12.99, call 01268 505 090

EASY SQUEEZY

IT’S A DATE

TICK TOCK

HELPING HAND

Looking for a stylish yet practical addition to your kitchen? This vintagelook citrus juicer by Ethos* ticks both boxes

Buy this beautiful diary to keep track of all your important dates and events and support research

You’ll never have to worry about burnt cakes and over-cooked dinners again with this handy 60-minute egg-shaped timer by Ethos*

Protect yourself while baking with this pretty oven mitt by Ethos* – pair it with the matching apron for top-to-toe pink hearts

£4.99, call 01268 505 090

£4.99, call 01268 505 090

£22.99, call 01268 505 090

£10.29, letts.co.uk £1 donation to Campaign

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We’re keeping busy

DATES FOR THE DIARY Exciting fundraising events, key dates to note, and a look at what’s ahead

2 Get stuck in, military-style, at the wet and muddy Major Series North

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MAY

APRIL

MARCH

6-14 Take on the challenge of a lifetime and trek the Great Wall of China

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Scale the highest mountain in Britain on the Summer Ben Nevis Trek

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8-9

Pound the streets and take in the sights at the Brighton Marathon

Hit the streets of London for the annual Moonwalk – every step counts!

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Brave the bogs and hills at the Major Series Midlands obstacle race

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Head to the Kent countryside for the challenging Major Series South

Join the masses for the Virgin London Marathon – it’s the world’s largest!

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Join our epic Sisters To The Summit Kilimanjaro Trek this spring

17 Slip on your trainers for the Mizuno Reading Half Marathon

SHOW YOUR SUPPORT Run for Campaign and you’ll get a big cheer on race day (right)

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Our annual Breast Cancer Campaign awards at the House of Lords

Get your running gear ready for the adidas Silverstone Half Marathon

Enjoy the historic sights as you run the Bath Half Marathon

JUNE/JULY MARCH 9

APRIL 6-14

Join Nightrider, a 100km moonlit cycle through the streets of London APRIL 21

Get involved in the rewarding Yorkshire Three Peaks Challenge

25-26 Run or even walk the 100km London 2 Brighton Challenge

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Spot the capital’s landmarks as you run the Bupa London 10,000

12-15 JULY

JUNE 8-9

Take on the famous trio and join us for the Three Peaks Challenge

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Swim, cycle and run in the Virgin Active London Triathlon

Coming soon 8 SEPT Run to the Beat powered by Nike+ 15 SEPT Bupa Great North Run 6 OCT Royal Parks Foundation Half Marathon 5-12 OCT Grand Canyon Trek NOV ING New York City Marathon 15-22 NOV Britain v Cancer Jordan Desert Trek

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TREK THE GRAND CANYON AND BE PART OF THE CURE

5-12 OCTOBEr 2013

Join Breast Cancer Campaign and trek the Grand Canyon to raise funds for vital, life-saving research. To receive your information pack now, call 020 7749 4114 or email treks@breastcancercampaign.org

breastcancercampaign.org

Registered Charity No: 299758


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