RESEARCH BRIEFS Infant Health Inequality Returns
U.S. must solve food insecurity, the high cost of health care, and homelessness to create equality of opportunity. Emily Rauscher, associate professor of sociology
David Rangel, assistant professor of education
THROUGHOUT THE 1990s AND 2000s, infant health inequality was improving. But that trend began to reverse in 2010, creating an ever-widening gulf whose ramifications could be felt for generations. That’s according to a study authored by EMILY RAUSCHER and DAVID RANGEL , two researchers affiliated with Brown’s Population Studies and Training Center. Their findings were published in December 2020 in the journal Social Science & Medicine – Population Health. The pair found that between 1989 and 2010, the health gap between infants born to the most socially advantaged mothers—those who are married, highly educated, and white—and infants born to the least socially advantaged mothers—those who are unmarried, without a high school diploma, and Black—steadily decreased. But beginning in 2010, that positive trend reversed course. The change is a concern, the authors explained, because multiple studies have shown that when infants are born underweight or more than three weeks before their due date, they may face complications that could affect mental, physical, and economic well-being for years to come. Research literature shows that those health complications are more likely to occur in infants born to mothers who face social and economic disadvantages. “Lots of Americans view the U.S. as a land of equal opportunity where hard work pays off,” said Rauscher, an associate professor of sociology at Brown. “But equality of opportunity is fundamentally impossible to achieve as long as there is inequality in infant health. When babies are born in underresourced communities, they are more likely to be born underweight or malnourished. They’re already at a disadvantage before they’ve even had an opportunity to do anything in the world.”—jill kimball
Disrupting Cancer Progression ONE CHALLENGE FACED by researchers and medical professionals working to develop new treatments for cancer is the presence of multiple kinds of cancer cells within the same tumor. Often these “mosaic” tumors include cells, such as polyploid giant cancer cells (PGCCs), that have evolved to become aggressive and resistant to chemotherapy and radiation. A study by Brown researchers published in Proceedings of the National Academy of Sciences expands the 12
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understanding of these previously overlooked cancer cells and identifies a potential target for treating them. Unlike most cancer cells that divide by mitosis, PGCCs undergo amitotic budding and then rapidly spread using filaments called vimentin. When replicating cells proliferate and become jammed together, vimentin provides PGCCs with a more flexible, elastic structure, which helps protect them from damage and allows them to squeeze past neighboring cells to escape to less-crowded areas.
UNSPLASH; NICK DENTAMARO/BROWN UNIVERSITY
Filaments called vimentin may be key to the spread of aggressive, chemoresistant cancer cells.
