/ Competence in the Pharmaceutical Sector / Like many sectors, the pharmaceutical industry is also undergoing digital change. Medicines have to be manufactured in ever faster time-to-market cycles, and pharmaceutical plants have to work more efficiently, more sustainably and more intelligently, without jeopardising the highly sensitive process reliability.
Inside this brochure you will find an overview of our strategic approach to serving your business needs, an insight into some unique products which provide the chance to enhance overall plant performance, make the very best of your space, reduce and even eliminate dead space to optimise cleaning and ultimately achieve a higher product yield. Through Bürkert’s customer oriented approach we have combined our knowledge and brought together an extended portfolio allowing us to offer our customers a more comprehensive and attuned range of customised products and system solutions.
Pharma 4.0
Our systems drive the digitisation of production processes in the pharmaceutical, healthcare and life science sectors. To do this, we adjust the process automation and device networking in order to optimise diagnostic, start-up or maintenance processes.
Extensive pharmaceutical expertise
Whatever media are fermented, filtered, separated or bottled in your systems – our fluid control experts and dedicated consultants develop needsbased and application-related systems for your company.
Everything from a single source
We offer you concepts from a single source with reliable delivery performance. This is because we think comprehensively and therefore of everything: a high level of vertical integration, optimally coordinated components for complete solutions, construction and approval of control cabinets in-house and a large portfolio of valves, sensors and controllers.
The hydroformed, lightweight diaphragm tube valve body will change the way you think about plant design and operation – as it helps you create more sustainable processes while meeting the industry’s demanding regulations. During operation, it can increase overall productivity of your plant.
Manual operated 2-way valves
Type 3233
2/2-way diaphragm valve offers a flow-efficient valve body with little dead space that enables high flow rates and a wide range of possible uses.. Product wetted surfaces in Ra ≤ 0.38 µm...1.6 µm (optionally electropolished).
Explosion-proof ATEX / IECEx available.
CLASSIC Pneumatically operated 2/2-way valves
Type 3234
T-diaphragm valve comes with optional plastic or stainless steel handwheel, ensures use in hygienic or aggressive ambient conditions. Product wetted surfaces in Ra ≤ 0.38 µm...1.6 µm (optionally electropolished). Explosionproof ATEX / IECEx available.
Type 3235
Tank bottom diaphragm valve offers a compact and autoclavable designed actuator. Product wetted surfaces in Ra ≤ 0.38 µm...1.6 µm (optionally electropolished).
Explosion-proof ATEX / IECEx available.
Type
2031
Externally controlled diaphragm valve consists of a pneumatically operated piston actuator, a diaphragm and a 2-way valve body. The proven and robust actuator with a plastic housing ensures use in hygienic or aggressive ambient conditions.
Type
2032
T-diaphragm valve with pneumatic plastic actuator has a compact, autoclavable design (PPS variant). The integration of the automation units 8690/8697 is possible in all configuration levels (can be retrofitted).
Type
2033
Tank bottom diaphragm valve with pneumatic plastic actuator ensures use in hygienic or aggressive ambient conditions. The flow-efficient valve bodies with little dead space enable high flow rates and a wide range of possible uses.
Type 2063
2/2 way diaphragm valve with pneumatic actuator in stainless steel (INOX). The proven and robust actuator with stainless steel valve body ensures use under hygienic or aggressive environmental conditions.
ELEMENT Pneumatically operated 2/2-way valves
Type 2103
2/2-way diaphragm valve with pneumatic stainless steel actuator (ELEMENT) for decentralised automation. The integration of automation units is possible in all configuration levels (can be retrofitted); a fieldbus interface can also be integrated.
Type 8801
ELEMENT On/Off Valve Systems with decentralised automation enables the easy integration of automation modules whether they are electrical/optical position feedback, pneumatic control units, an optional integrated fieldbus interface or even an explosion proof control head.
Type 8802
ELEMENT continuous control valve systems enables the easy integration of digital automation modules in all extension stages. The fully integrated system with control valve and automation unit has a compact and smooth design, integrated pneumatic lines, IP65/67/NEMA 4X degree of protection and superior chemical resistance..
Type 2036
Robolux Multiway/multiport diaphragm valve pneumatically operated
This multiway diaphragm valve was designed to control ultra-pure, sterile, aseptic, steam and CIP media. It enables optimum sampling, draining and distribution of critical process media. The valve programme is based on the patented Robolux technology, wherein the diaphragm
actuates two crossbars. With this concept, dead spaces are avoided and the flow volume is reduced. The valve body is carved from a stainless steel block. The highquality diaphragms are available in various materials with USP Class VI certification. The valve is operated
with compressed air. With the special position feedback indicators and control heads, Robolux can be perfectly integrated into Bürkert’s decentralised automation concept.
The multiCELL is the perfect device to collect and control all of the CIP cleaning processes.
Purity under control – the multicell collects and logs data from up to twelve sensors. You can check temperature, pH, conductivity, ORP, chlorine or any analogue parameter at a glance. If required, this device can also perform a range of
dosing and control functions with a simple, intuitive user interface.
The FLOWave is based on SAW (Surface Acoustic Waves) technology and designed for applications with the highest hygienic demands. This is achieved by using: suitable stainless steel materials and a measuring tube free of any wetted parts except for the actual tube. This flowmeter
offers a range of integrated functions, including flexibility, ease of cleaning, compact dimensions, lightweight, easy installation and handling. Optimal measurement results can be achieved with homogeneous liquids, free of air and solid particles.
EVA is available as both open/close and modulating control
Type 3323
Electromotive 2/2 way diaphragm valve (ON/OFF)
The externally controlled diaphragm valve consists of an electrically controlled linear actuator (open/close) with recirculating ball screw ensures use under hygienic or aggressive environmental conditions. To protect the
diaphragm the actuator has a drive force adjustment. A correspondingly high IP protection IP65/IP67 ensures adequate splash protection. High speeds of up to 6 mm/s.
Type 2100
Pneumatically operated 2/2-way angle seat valve ELEMENT
This valve is specially optimised for decentralised process automation and fulfils the tough criteria in process environments. Its unique design allows easy the integration of automation units in all expansion stages, from electrical/optical position feedback to pneumatic control and
integrated fieldbus interface. High flow rates, long service life and easy integration utilising ELEMENT control heads for networked connectivity.
Type 8619 Transmitters & Controllers Type 8098 FLOWave SAW flowmeter
Block & tank valve solutions for pharmaceutical applications
/ New thinking, new technology, new design / Main diaphragm valve configurations have largely been replaced by modern Block Valve Solutions. The key advantages of Block Valve Solutions is the reduced hold up of volume, reduced footprint and compactness for tight installs. The design is without internal welding which enables complex designs that are not feasible with traditional welded configurations. The unique patented advanced Robolux twin-weir diaphragm valve system even exceeds the single weir block solutions in its compactness. This further evolution of the design virtually eliminates dead legs in some configurations completely and reduces the internal hold up volume to its absolute minimum. Due to the further reduced weight this design is quicker to heat up and cool down.
Block Valve Solutions
Traditional Conventional Robolux
Type 2034
Multifunction block and weld solution
Minimum deadleg. Hermetical separation of fluids from the operating mechanism by diaphragm. Easy integration of automation units with ELEMENT. Variable block and weld bodies. Quality certifications FDA/3A
/ Understanding the process / In the world of pharmaceutical manufacturing; compactness, smart communications, plant footprints, cleaning and sterilisation, dead legs, cross-contamination, and validation are everyday concerns. Through the sterile process area the scope of systems and components from the alliance cover all the different application environments –effective and efficient in each application whilst working harmoniously together to provide a reliable total plant solution. Pharmaceutical manufacturing relies on utilities liquids and gasses being readily available and of the desired quality. This means controlled conditions, accurate pressures and temperatures and variations of other measurements according to specific duty. These applications are critical in upstream integrity as well as overall plant performance. Each area demands strict control and yet flexibility is often a key desire – you can be certain that both mechanical and instrumentation equipment are system designed to realise these goals offering enhanced plant lifecycle with high integrity and satisfaction.
Type 8745
Mass flow controller
Mass flow meter
• Suitable for mass flow control of high flow rates
• Thermal inline sensor located directly in the main gas stream provides for very fast response times while causing very low pressure drop.
Type 8741
Mass flow control
Mass flow meter
• CANopen based Bürkert system bus (büS) is suitable for the integration into existing CANopen networks, as well as Industrial Ethernet or fieldbus networks in combination with the fieldbus gateway of Type ME43
Type 8742
Mass flow controller
Mass flow meter for multichannel gas flow systems
• Suitable for a wide range of applications
• High accuracy and repeatability
• Especially designed for use in harsh environments due to high protection class and explosion-proof
Future-proof automation solutions
Type 8746
Mass flow controller for multi-channel gas flow systems (multi-MFC system)
• Particularly efficient mass flow controllers for use in multi-MFC systems.
• Easy integration and a high level of efficiency if a plant is equipped with a higher number of flow control loops.
/ Is the pressure in the tank correct? / Filling or emptying tanks often presents you with challenges. For example, the valuable medium must be screened or the exchange of liquid and air must be compensated for. In many cases, you need constant overpressure to safeguard product quality. In processes such as fermentation, organisms in the tank are continuously releasing gases. To control the prevailing pressure, they must be precisely released over time. In this scenario, hygienic pressure control systems provide maximum safety – ensuring the pressure in the tank is correct.
Type 2380
Pressure control system
Better process reliability
Since the response time is decisive, we have integrated the functionality directly in the system. The signal from the controller reaches the actuator in half the time – thereby improving the reliability of your process.
Optimum pressure control
Stable gas pressure control protects sensitive media against the ingress of air. With the Bürkert solution, you can maintain the ideal overpressure in every situation, even if the tank is moving.
Precise filling
No matter how full or empty your tank is: The pressure on the product can be so finely adjusted that a precisely dosed volume is filled at all times.
Reduced maintenance workload
The compact system solution can be attached directly to the tank. During cleaning, the components are not damaged – this saves maintenance costs and guarantees constant performance throughout the product life cycle.
/ Precise gas control / With mass flow controllers (MFCs) by Bürkert, the fermentation process is reproducible. With their help, you can adjust the flow rate automatically and repeatably. The devices conform to USP Class VI, FDA and can be supplied with acceptance test certificate 3.1. In contrast to the measurement with variable area flowmeters using needle valves, they guarantee high quality and identical processes. Thanks to the high turn-down ratio, you can control very small to large gas flow rates with extreme precision.
Measurement points
• ORP
• Temperature
• pH
• Pressure
• pO2
Conventional solution
Rotameters are mechanical devices that measure the flow rate of a fluid in a closed tube. However, the principle used is based neither on mass-flow nor volume-flow measurement. They must be precisely calibrated and only function at the pressure and temperature for which they have been set.
Approval
To ensure the quality of the final product, the components used must conform to the applicable approvals.
WFI circuit: Increasing security and saving operating costs with local control loops of valves and sensors
Water for injection (WFI) for the pharmaceutical industry requires special handling. Quality needs to be controlled and documented and flow velocities need to be measured and regulated so that purity and availability can be consistently guaranteed. The amounts of energy required for the production, distribution and storage of WFI result in significant operating costs. At the same time, environmental protection and sustainability are becoming increasingly important at many pharmaceutical companies. This makes the energy efficiency of a plant an important issue in the overall investment decision, a decision we are happy to help you with. Watch our video for more information.
Water quality monitoring
The challenge - to ensure high water quality for formulating high-quality cosmetics and body care products. The Bürkert solution: the water quality can be continuously monitored in an efficient manner with our state-of-the-art type 8905 online analysis system and its analysis sensors. Your Benefits through our Water Quality Monitoring System is that all measurement data available at a glance thanks to digital interfaces and an easily read display including pH, free chlorine, turbidity, conductivity and ORP. This complete unit provides consistent monitoring for high quality water. Watch our video for more information.
Ensure the quality of your pharmaceutical product with the help of optimum flow measurements in ultrapure water and Clean in Place (CIP) applications
In pharmaceutical production, safe processes are the key to guaranteeing safe drugs. Bürkert’s innovative FLOWave flowmeter helps you meet hygienic safety standards while increasing productivity in Clean in Place and ultrapure water applications. The burkert solution enables precise measurment of the flow in the auxiliary cycles of pharmaceutical production. Watch our video for more information.
