cells at work performance task e. coli cells | enzymes for glycolysis CAPSULE FIMBRIAE
CELL MEMBRANE
PLASMIID DNA
CYTOPLASM
NUCLEOID DNA
RIBOSOMES FLAGELLUM
CELL WALL
FIRST COMIC OF THE PROTEIN SYNTHESIS SERIES submitted by john bangyao character design ernest joshua cabayao layout artist cyril andre durango storyboard artist leigh angeli libradilla story writer duane ydrian tuico character design
THIS IS A WORK OF FICTION. NAMES, CHARACTERS, PLACES, AND EVENTS ARE USED FICTITIOUSLY. ANY RESEMBLANCE TO ACTUAL NAMES OF PEOPLE, PLACES AND EVENTS IS ENTIRELY COINCIDENTAL. COPYRIGHT © 2021 BY STEM 12 BLOCK M1 E. COLI GROUP
RNA POLYMERASE COMMANDING OFFICER, PRT-E-1123, HAS GOTTEN THE MESSAGE TO PRODUCE ENZYMES FOR GLYCOLYSIS. HE HAS TRAVELLED THROUGH THE NUCLEOID TO FIND THE PARTICULAR GENE TO CODE FOR THE NEEDED ENZYME.
TATA BOX located. I repeat. TATA box located.
Initiating transcription sequence. Transcription Factors, get into position
THE TATA BOX IS A DNA SEQUENCE THAT INDICATES WHERE A GENETIC SEQUENCE CAN BE READ AND DECODED.
CLI
CK
TFIID Complex is in position. TFIIA is in position.
TFIIB
TFIID COMPLEX
TFIID COMPLEX TFIID COMPLEX
TFIIB is in position.
TFIIB
RNA Polymerase attached. ATP missile is now approaching.
K
TFIIB
CLIC
CLIC
K
Contact in 3...
TFIIB
TFIID COMPLEX
TFIIB
TFIIA TFIIA
TFIIA
Copy that. Attaching RNA Polymerase now.
RNA P RNA 1...
RNA RNA POLYMERA AD POLY P
CLICK
TFIIA
2...
P AT
P AT
PI
AFTER ENERGY IS ADDED THROUGH THE REDUCTION OF ATP INTO ADP AND PI, RNA POLYMERASE PICKS UP FREE-FLOATING NUCLEOTIDES AND BINDS THEM TOGETHER TO FORM MESSENGER RNA
TFIIB
TFIID COMPLEX
TFIIA
RNA POLYMERASE ADP
PI
TFIIA
TFIIB
FIID OMPLEX
RNA POLYMERA
ONE MINUTE LATER...
We have reached the termination sequence. Detaching RNA polymerase now. Drone 5’ Cap will now deliver the mRNA to Ribosome City.
And I can hear you goofing from the radio, TFs. We still have other genes to replicate.
5’
CAP PROTECTS THE MESSENGER RNA FROM BEING BROKEN DOWN.
Like I said, tRNA-324, you do not match. A FEW MINUTES LATER...
I’ve been waiting too many hours and this Aspartate is getting heavier by the minute!!! I don’t care. So either you back off or I’ll throw you out.
E THROUGH THE INITIATION FACTORS, THE RIBOSOME SPLITS UP INTO TWO, AND THE SMALLER SUBUNIT (CONTAINING 16S RIBOSOMAL RNA) BINDS INTO THE MESSENGER RNA’S SHINE-DELGARNO’S SEQUNECE
ETIS-A
The last thing I need is someone delaying my work.
THE A-SITE IS RESPONSIBLE FOR MATCHING THE TRANSLATION RNA ANTICODONS WITH THE CODONS OF THE MESSENGER RNA.
Now I see what the problem is...
I don’t see why I have to wait for my turn just because my codons don’t match!
ETIS-A
You’re new, arent you?
Yeah, how did you know?
While you are just sitting in here, we, on the outside, are tired carrying this amino acid in our hands.
*scoffs* It’s always the new ones...
AMINO ACIDS ARE BUILDING BLOCKS OF PROTEINS.
This series of codons is replicated from the True Source. True Source never lies, you know that.
True Source, as in, Source of all the information. The code to life?
Yes.
Imagine if I wasn’t here to check if the codon’s matched.
Imagine if there were no transcription factors to successfully replicate the True Source.
In both situations, this cell would cease to exist.
We would cease to exist.
I understand that you’re new. But know this. Remember your purpose. A small act as simple as skipping your codon match could destroy this world we live in. I see... Thank you for making me understand. Now, get out of my sight. My protein shipment has been delayed because of you.
A FEW MINUTES LATER, TRNA-324 HAD MATCHED THE CODON OF THE MESSENGER RNA AND HAS BEEN DRAGGED INTO THE P-SITE WHERE HE CAN BIND HIS ASPARTATE AMINO ACID WITH OTHER AMINO ACIDS.
P-SITE PLACE YOUR
AMINO
ASPARTATE
ACID INSIDE HERE
ALTHOUGH, HE MIGHT BE STAYING INSIDE THE P-SITE FOR A WHILE AFTER OVERHEARING A NEWLY HIRED TRANSEFER RNA ARGUING WITH THE RIBOSOMAL RNA IN THE A-SITE.
AFTER ANOTHER FEW MINUTES, THE STOP CODON HAS NOW BEEN READ INSIDE THE RIBOSOME, SIGNALLING THE HALT AND END OF TRANSLATION PROCESS. THE RIBOSOME THEN DISASSOCIATES WITH THE MESSENGER RNA
SECONDARY STRUCTURE
PRIMARY STRUCTURE TERTIARY STRUCTURE
E SOM O B I R THE POLYPEPTIDE WILL THEN START TO FOLD, FORMING THE NECESSARY PROTEINS FOR THE CELL. THIS TIME, ENZYMES FOR GLYCOLYSIS.
THE END CHARACTER DESIGN LAYOUT ARTIST STORYBOARD ARTIST STORY WRITER
JOHN BANGYAO DUANE YDRIA TUICO ERNEST JOSHUA CABAYAO CYRIL ANDRE DURANGO LEIGH ANGELI LIBRADILLA
EACH AND EVERY ONE OF US HAS A PURPOSE IN THIS WORLD. FIND THAT PURPOSE, AND SOON YOU WILL UNDERSTAND. TWO DIFFERENT WORK ENVIRONMENTS, ONE PURPOSE. THAT PURPOSE IS TO PRODUCE ENZYMES. INSIDE THE E. COLI, THERE ARE HUNDREDS OF ENZYMES AND PROTEINS WORKING TO MAKE ENZYMES FOR THE CELL’S GLYCOLYSIS. WHILE ONE WORKPLACE SMOOTHLY DOES THEIR JOB, THE OTHER... NOT SO MUCH.