Eili Y. Klein Center for Disease Dynamics, Economics & Policy 1616 P Street NW, Suite 430, Washington, DC 20036 732.266.7732 • klein@cddep.org • www.eiliklein.com
EDUCATION Princeton University, Princeton, NJ PhD in Ecology and Evolutionary Biology, 2012 Thesis: Anti-malarial Drug Resistance Johns Hopkins University School of Advanced International Relations, Washington, DC Master of Arts, International Health Policy, 2005 Columbia University, New York, NY Bachelor of Arts, Economics, 1998 PROFESSIONAL EXPERIENCE Center for Disease Dynamics, Economics & Policy 2012Fellow 2010-2012 Research Associate Johns Hopkins University 2012Faculty, Department of Emergency Medicine Resources for the Future 2005-2010 Research Associate; Research Assistant RESEARCH INTERESTS Impact of behavior and social structure on the spread of infectious disease. Impact of antimicrobial drug resistance on ecology and epidemiology of disease. Economic epidemiology. Mathematical and theoretical ecology. Evolution of pathogen-host interactions. Pathogen competition across space and scale. Influenza viral evolution. HONORS & AWARDS Hartwell Foundation Biomedical Research Fellowship (2015) NIH Loan Repayment Program (2013) Johns Hopkins Emergency Department Research Day Award for Best Research Presentation (2012) The May Fellowship, Princeton University (2008-09,2010-11) Harold W. Dodds Honorific Fellowship, Princeton University (2011-12) C. Grove Haines Prize, JHU-SAIS (2004) PUBLICATIONS JOURNAL ARTICLES 2015 Cole, Gai, Dicky Stefanus, Heather Gardner, Matthew J Levy, Eili Y Klein (2015) “The impact of interruptions on the duration of nursing interventions: a direct observation study in an academic emergency department BMJ Quality & Safety” (doi:10.1136/bmjqs-2014-003683). Klein, Eili Y., David L. Smith, Justin M. Cohen, Ramanan Laxminarayan (2015) “Cost-effectiveness Analysis of Targeting Children Compared to the Whole Population for Continuing Subsidies for
Eili Y. Klein Page 2 ACTs Using a Bioeconomic Malaria Model” Journal of the Royal Society Interface 12(107): 20141356. Klein, Eili Y., Michael Makowsky, Megan Orlando, Erez Hatna, Nikolay P. Braykov, Ramanan Laxminarayan (2015) “Influence of provider and urgent care density across different socioeconomic strata on outpatient antibiotic prescribing in the USA” Journal of Antimicrobial Chemotherapy 70(5): 1580-1587. 2014 Broniatowski, David A., Eili Y. Klein, Valerie Reyna (2014) “Germs are Germs, and Why Not Take a Risk?: Patients’ Expectations for Prescribing Antibiotics in an Inner City Emergency Department” Medical Decision Making 35(1):60-67. Kouyos, Roger D., C. Jessica E. Metcalf, Ruthie Birger, Eili Y. Klein, Pia Abel zur Wiesch, Peter Ankomah, Nimalan Arinaminpathy, Tiffany L. Bogich, Sebastian Bonhoeffer, Charles Brower, Geoffrey Chi-Johnston, Ted Cohen, Troy Day, Bryan Greenhouse, Silvie Huijben, Joshua Metlay, Nicole Mideo, Laura C Pollitt, Andrew F. Read, David L. Smith, Claire Standley, Nina Wale, Bryan Grenfell (2014) “The path of least resistance: aggressive or moderate treatment?” Proceedings of the Royal Society, Series B: Biological Sciences 281(1794): 20140566. May, Larissa, Gudger G, Armstrong P, Brooks G, Hinds P, Bhat R, Moran G, Schwartz L, Cosgrove SE, Klein EY, Rothman RE, Rand C (2014) “Multisite Exploration of Clinical Decision-Making for Antibiotic Use by Emergency Medicine Providers Using Quantitative and Qualitative Methods” Infection Control and Hospital Epidemiology 35(9): 1114-1125. Klein, Eili Y., Serohijos AWR, Choi J-M, Shakhnovich EI, Pekosz A (2014) “Influenza A H1N1 Pandemic Strain Evolution - Divergence and the Potential for Antigenic Drift Variants” PLoS ONE 9(4): e93632. Smith, David L., T. Alex Perkins, Robert C Reiner, Christopher M. Barker, Tianchan Niu, Luis Fernando Chaves, Alicia M. Ellis, Dylan B George, Arnaud Le Menach, Juliet R. C. Pulliam, Donal Bisanzio, Caroline Buckee, Christinah Chiyaka, Derek A. T. Cummings, Andres J. Garcia, Michelle L. Gatton, Peter W. Gething, David M. Hartley, Geoffrey Johnston, Eili Y. Klein, Edwin Michael, Alun L. Lloyd, David M. Pigott, William K. Reisen, Nick Ruktanonchai, Brajendra K. Singh, Jeremy Stoller, Andrew J. Tatem, Uriel Kitron, H. Charles J. Godfray, Justin M. Cohen, Simon I. Hay, Thomas W. Scott (2014) “Recasting the Theory of Mosquito-Borne Pathogen Transmission Dynamics and Control” Transactions of the Royal Society of Tropical Medicine and Hygiene 108(4): 185-197. May, Larissa, Eili Y. Klein, Richard E. Rothman, Ramanan Laxminarayan (2014) “Trends in Antibiotic Resistance in Coagulase Negative Staphylococci, United States, 1999-2012” Antimicrobial Agents and Chemotherapy 58(3): 1404-1409. Walker, Josephine G., Eili Y. Klein, and Simon A. Levin (2014) “Disease at the wildlife-livestock interface: Acaricide use on domestic cattle does not prevent transmission of a tick-borne pathogen with multiple hosts” Veterinary Parasitology 199(3-4): 206-214. Klein, Eili Y. (2014) “Cross-Reactive Immune Responses as Primary Drivers of Malaria Chronicity” Infection and Immunity 82(1):140-151. Klein, Eili Y. (2014) “The Impact of Heterogeneous Transmission on the Establishment and Spread of Antimalarial Drug Resistance” Journal of Theoretical Biology 340:177-185.
Eili Y. Klein Page 3 2013 Klein, Eili Y., Ramanan Laxminarayan (2013) “The potential impact of age and season on methicillin-resistant Staphylococcus aureus prevalence” Future Microbiology 8(7):809-812. Wells, Chad R., Eili Y. Klein, and Chris T. Bauch (2013) “Policy Resistance Undermines Superspreader Vaccination Strategies for Influenza” PLoS Computational Biology 9(3):e1002945. Kouyos, Roger, Eili Klein, Bryan Grenfell (2013) “Hospital-Community Interactions foster coexistence between methicillin-resistant strains of Staphylococcus aureus” PLoS Pathogens 9(2): e1003134. Klein, Eili Y., Lova Sun, David L. Smith, Ramanan Laxminarayan (2013) “The changing epidemiology of methicillin-resistant Staphylococcus aureus in the United States: A national observational study” The American Journal of Epidemiology 177(7): 666-674. Klein, Eili Y. (2013) “Antimalarial Drug Resistance: A Review of the Biology and Strategies to Delay Emergence and Spread” International Journal of Antimicrobial Agents 41(4): 311-317. Reiner Jr., Robert C., T. Alex Perkins, Christopher M. Barker, Tianchan Niu, Luis Fernando Chaves, Alicia M. Ellis, Dylan B. George, Arnaud Le Menach, Juliet R. C. Pulliam, Donal Bisanzio, Caroline Buckee, Christinah Chiyaka, Derek A. T. Cummings, Andres J. Garcia, Michelle L. Gatton, Peter W. Gething, David M. Hartley, Geoffrey Johnston, Eili Y. Klein, Edwin Michael, Steven W. Lindsay, Alun L. Lloyd, David M. Pigott, William K. Reisen, Nick Ruktanonchai, Brajendra K. Singh, Andrew J. Tatem, Uriel Kitron, Simon I. Hay, Thomas W. Scott, and David L. Smith (2013) “A Systematic Review of Mathematical Models of Mosquito-Borne Pathogen Transmission: 19702010” Journal of the Royal Society Interface 10(81): 20120921. Braykov, Nikolay, Michael R. Eber, Eili Y. Klein, Daniel J. Morgan, and Ramanan Laxminarayan (2013) “Trends in resistance to carbapenems and third-generation cephalosporins among clinical isolates of Klebsiella pneumoniae in the United States, 1999-2010” Infection Control & Hospital Epidemiology 34(3): 259-68. 2012 Klein, Eili and Ramanan Laxminarayan (2012) “Resistance movement” Modern Healthcare 42(32):22. Klein, Eili Y., David L. Smith, Ramanan Laxminarayan, and Simon Levin (2012) “Superinfection and the evolution of resistance to antimalarial drugs” Proceedings of the Royal Society, Series B: Biological Sciences 279(1743):3834-3842. Sun, Lova, Eili Y. Klein, and Ramanan Laxminarayan (2012) “Seasonality and Temporal Correlation between Community Antibiotic Use and Resistance in the United States” Clinical Infectious Diseases 55(5):687-694. Klein, Eili Y., Ian A. Lewis, Christina Jung, Manuel Llins, and Simon A Levin (2012) “Relationship between treatment-seeking behaviour and artemisinin drug quality in Ghana” Malaria Journal 11:10. 2007-2011 Tozan, Ye¸sim, Eili Y. Klein, Sarah Darley, Rajashree Panicker, Ramanan Laxminarayan, and
Eili Y. Klein Page 4 Joel G. Breman (2010) “Prereferral Rectal Artesunate for Treatment of Severe Childhood Malaria: a Cost-Effectiveness Analysis” Lancet 376(9756):1910-1915. Smith, David L., Eili Y. Klein, F. Ellis McKenzie, and Ramanan Laxminarayan (2010) “Prospective Strategies to Delay the Evolution of Antimalarial Drug Resistance: Weighing the Uncertainty” Malaria Journal 9:217. Chow, Jeffrey, Eili Y. Klein, and Ramanan Laxminarayan (2010) “Cost-Effectiveness of ‘Golden Mustard’ for Treating Vitamin A Deficiency in India” PLoS One 5(8):e12046 Laxminarayan, Ramanan, Ian W.H. Parry, David L. Smith, and Eili Y. Klein (2010) “Should New Antimalarial Drugs be Subsidized?” Journal of Health Economics 29(3):445-456. Klein, Eili, David L. Smith, and Ramanan Laxminarayan (2009) “Community-associated MethicillinResistant Staphylococcus aureus in Outpatients, United States, 1999-2006” Emerging Infectious Diseases 15(12):1925-1930. Saranath Lawpoolsri, Eili Y. Klein, Pratap Singhasivanon, Surapon Yimsamran, Nipon Thanyavanich, Wanchai Maneeboonyang, Laura L Hungerford, James H Maguire, and David L Smith (2009) “Optimally timing primaquine treatment to reduce Plasmodium falciparum transmission in low endemicity Thai-Myanmar border populations” Malaria Journal 8:159. Laxminarayan, Ramanan, Eili Klein, Sarah Darley, and Olusoji Adeyi (2009) “Economic Benefits of Global Investments in Tuberculosis Control” Health Affairs 28(4):w730-42. Klein, Eili, David L. Smith, Maciej F. Boni, and Ramanan Laxminarayan (2008) “Clinically Immune Hosts as a Refuge for Drug-Sensitive Malaria Parasites” Malaria Journal 7:67. Reik, Rebecca, Fred Tenover, Eili Klein, and Lawrence Clifford McDonald (2008) “The Burden of Vancomycin-Resistant Enterococcal Infections in U.S. Hospitals, 2003-2004” Diagnostic Microbiology and Infectious Disease 62(1):81-85. Klein, Eili, David L. Smith, and Ramanan Laxminarayan (2007) “Hospitalizations and Deaths Caused by Staphylococcus aureus and MRSA, United States, 1999-2004” Emerging Infectious Diseases 13(12):1840-46. Klein, Eili, Ramanan Laxminarayan, David L. Smith, and Christopher Gilligan (2007) “Economic Incentives and Mathematical Models of Disease” Environment and Development Economics 12(5):707-32. BOOK CHAPTERS Klein, Eili Y., Julia Chelen, Michael D. Makowsky, and Paul E. Smaldino (2015) “The need for more integrated epidemic modeling, with emphasis on antibiotic resistance” In R. Melnik (ed). Mathematical and computational modeling: With applications in the natural and social sciences, engineering, and the arts pp. 121-134. New York: Wiley. Klein, Eili (2013) “How Misaligned Incentives Influence Antibiotic Prescribing and Resistance” In Emerging and Persistent Infectious Diseases: Focus on Antimicrobial Resistance (pp. 24-28). Washington, DC: Institute on Science for Global Policy (ISGP). Laxminarayan, Ramanan, Eili Klein and Sarah Darley (2010). “Controlling Tuberculosis: What is the Benefit, at What Cost?” In I. W. Parry and F. Day (eds). Issues of the Day: 100 Com-
Eili Y. Klein Page 5 mentaries on Climate, Energy, the Environment, Transportation, and Public Health (pp. 184-185). Washington, DC: Resources for the Future. BOOKS AND REPORTS Centers for Disease Control (2013) “Vital Signs: Carbapenem-Resistant Enterobacteriaceae” MMWR. Morbidity and Mortality Weekly Report 62:1-6. Laxminarayan, Ramanan, Jeffrey Chow, Eili Klein and Paula Whitacre (2007) Closing India’s Nutrition Gap: The Role of Golden Mustard in Fighting Vitamin A Deficiency Resources for the Future, Washington, DC. WORKING PAPERS Makowsky, Michael and Eili Y. Klein (2014) “Identifying the Relationship between Length of Hospital Stay and the Probability of Readmission” Available at SSRN: http://ssrn.com/abstract=2463856 or http://dx.doi.org/10.2139/ssrn.2463856. Laxminarayan, Ramanan, Eili Klein, Christopher Dye, Katherine Floyd, Sarah Darley and Olusoji Adeyi (2007) “Economic Benefit of Tuberculosis Control” World Bank Policy Research Working Paper No. 4295, World Bank, Washington, DC Laxminarayan, Ramanan, Ian W.H. Parry, David L. Smith, and Eili Klein (2006) “Should New Antimalarial Drugs Be Subsidized?” RFF Discussion Paper 06-43. OTHER PUBLICATIONS Laxminarayan, R., Jeffrey Chow, Eili Klein, and Paula Tarnapol Whitacre (2008) “A Recipe to Fight Vitamin A Deficiency in India: Add Mustard and Stir?” Resources 167 (Fall/Winter). REFEREE American Journal of Infection Control American Journal of Tropical Medicine & Hygiene BMC Infectious Diseases Bulletin of Mathematical Biology Clinical Infectious Diseases Health Affairs Infectious Diseases of Poverty Journal of Infection Lancet Global Health Malaria Journal MalariaWorld Journal PLoS One PLoS Computational Biology PLoS Medicine Proceedings of the National Academy of Sciences (PNAS)