APRIL 9–15, 2015
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VOL. 40 NO. 14
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MADISON, WISCONSIN
BAD TRIP
A new wave of psychedelic drugs puts teens and police in peril JOE ANDERSON
Winner of the 2013 Tony Award for Best Play
by Christopher Durang APRIL 9 –26, 2015 | OVERTURE CENTER FORWARDTHEATER . COM
for tickets www.OVERTURECENTER.org or 608.258.4141
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Samuel Hutchison in Recital
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ISTHMUS.COM APRIL 9–15, 2015
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$20 at madisonsymphony.org/hutchisonrecital, TICKETS Overture Box Office, or (608) 258-4141. Student rush $10 day of concert
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n COVER STORY
BADTRIP The drug 25I — or ‘smiles’ — is becoming increasingly popular among teens BY NOAH PHILLIPS
Carol Carlson was home one afternoon late last fall
JOE ANDERSON
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APRIL 9–15, 2015 ISTHMUS.COM
chopping vegetables when her 16-year-old son, Alex, started running up and down the basement stairs. “His pupils were really dilated, and he was clearly not sober, but his behavior was nothing like being stoned and nothing like being drunk,” remembers Carol. “It was like ecstatic happiness, combined with punching.” When she questioned her older son, Peter, about what was going on, he confessed that he and Alex had taken a psychedelic drug called “25I.” “I had never heard of 25I; I just was told that it was ‘like acid,’” says Carol (the family has been given pseudonyms for this article). When Carol’s husband, Greg, came home, Alex ran up to him, nearly knocking him over. The teen was frantic, repeatedly shouting phrases such as “Thank you!” and “Get in my belly!” Greg knew he was in for a long night. “I realized that I was going to have to monitor him,” remembers Greg. “My wife and I knew that in the state he was in we needed to maintain a continual state of calmness and de-escalation.” 25I, which is in a family of drugs also known as “n-bomb” and “smiles,” is part of a new wave of synthetic street psychedelics that have been gaining in popularity among young, white Madisonians. Lt. Jason Freedman, a Madison police officer who is part of the Dane County Narcotics Task Force, says that in coming years these drugs may overshadow heroin as the focus of his unit.
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n COVER STORY
“I think five years from now we might be having those conversations, especially if these drugs continue into our market and they start killing people or causing real distress,” he says. “We’re not seeing it a lot, but I think it’s more prevalent than people think, and I think that trend is increasing.” Use of the drug in Madison has coincided with growing concern over use of deadly force by police officers engaging with individuals behaving irrationally. On March 6, a Madison police officer killed unarmed 19-year-old Tony Robinson, who his family says was under the influence of hallucinogenic mushrooms. Robinson had been acting erratically, running into traffic and allegedly assaulting two people, before officer Matt Kenny shot him. The situation at the Carlson house got scary when Alex punched his mother in the back of the head. Carol, Greg and Alex all emphasize that there was no anger or aggression in this act — his mood was cheerful, although he seemed to have little control over his body. Alex thought he was “petting” his mother. However Peter, who also on the drug, perceived Alex’s behavior much differently. He angrily picked up Alex, held him against a cabinet and broke his nose. As the blood began to flow, Greg and Carol grew frightened for their son. “At that point, of course, is when we started thinking, ‘do we call 911?’” remembers Carol, who was worried how a police officer might react to her son’s erratic behavior. “If any police officer were to walk into that scene and see all the blood,” agrees Greg, “they would instantly be in trigger mode, and that was just too dangerous.”
The drug Alex dosed on is known to the scientific
LAUREN JUSTICE
ISTHMUS.COM APRIL 9–15, 2015
Lt. Jason Freedman, a Madison police officer who is part of the Dane County Narcotics Task Force, fears synthetic hallucinogens like 25I may overshadow heroin in a few years as the biggest drug menace.
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JOE ANDERSON
community as “25I-NBOMe,” but is known colloquially as 25 n-bomb. Like other psychedelic compounds, 25 n-bomb binds to a serotonin receptor in the brain called 5ht2a, which is situated on cell membranes. When certain compatible chemicals bind to 5ht2a on the outside of the cell, the portion of the receptor located inside the cell changes shape, which leads to biochemical reactions — reactions that no one yet understands. “Inside the cell, that’s where you wave your hands and say, ‘then something happens,’” says Dave Nichols, a retired Purdue chemistry professor who has been working with psychedelics since 1969. “We don’t actually know [what happens]. We [only] know the parts of the brain that are involved.” The 5ht2a receptor is involved in regulating mood as well as processing sensory information. When psychedelic chemicals bind to these receptors, it changes the way the brain experiences sight, sound and touch. When Alex took 25I, for instance, he hallucinated that clouds and flowers were coming out of his cell phone. 25 n-bomb was never intended for human use — the compound was first discovered in Germany in 2003 by Ralf Heim, a chemist doing work for his doctorate with arteries in rabbit ears. “He was taking molecules that were known to bind to [5ht2a] and dissecting [them] piece by piece trying to find out what part of the molecule was necessary,” says Nichols. “He wasn’t trying to make a new psychedelic or anything, he was trying to understand another type of drug that binds to a receptor, but doesn’t have any activity.” But his chemical compounds did have activity; not only did they activate the receptors, they stayed attached much longer than most chemicals. At Purdue, Nichols took notice. His research involved trying to understand the function of the 5ht2a receptors, and he hoped studying the chemical that alters them might help him figure that out.
2015/16 SEASON AT OVERTURE SUBSCRIBE NOW! The drugs were simple to make, and after giving them to rats he found the drugs in the 25 n-bomb family to be drastically more potent than anything he had ever seen. “They probably have the highest affinity for the serotonin receptor of any compound that’s ever been discovered,” Nichols says. “I think it has something to do with the degree to which they stick to those receptors.” Outside of the molecular pharmaceutical biochemist community, however, the chemical remained largely unknown until Nichols published his results in 2006. “It was kind of obscure until we published a paper that showed these things were extremely potent, and I think that’s where the street chemists picked up on it,” says Nichols. “They were essentially mining the literature.”
Consumption of 25 n-bomb became illegal in fall 2013, reflecting its growing recreational use. No literature exists on its effects on the human body. “Synthetic drugs like these have no consistent manufacturing and packaging processes,” reads a 2013 U.S. Drug Enforcement Agency press release, which also notes that the drug has been implicated in 19 deaths. “[They] may contain drastically differing dosage amounts, a mix of several drugs, and unknown adulterants. Users are playing Russian roulette when they abuse them.” Teenager Alex Carlson describes its effects as quite frightening. “I took two 1,500 microgram tabs, a total of three milligrams, and completely lost my ego and went into a severe time loop,” Alex says. “I had no control of myself; I thought I could astral-project, I was trying to teleport, I thought I lived in a world where my actions were completely inconsequential, like I lived in kind of a matrix-like world where I could do whatever, like a dreamland.” In addition to these effects, 25 n-bomb has caused several overdoses since its arrival on the street. Nobody in either the scientific or the medical community knows why. “Most psychedelics are not that dangerous,” says Nichols. “LSD has never killed anybody, psychedelics have a reputation of being nontoxic. It’s only these n-bomb compounds that have ended up being lethal, and no one really understands what’s going on there.” Taking this drug is “definitely not a good idea,” Nichols warns. “Even people who have experience with street drugs have [had] serious adverse effects and even death after taking this.”
been part of a police unit that investigates drug dealers and drug activity. “We see everything here,” he says. “It’s just a question
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Since the late ’90s, Lt. Freedman has
of when we see it, how much we see it, how often we see it.” During the last few years the task force has focused on tackling heroin dealers, but Freedman has registered the uptick in synthetic drug use. “Based on everything I’ve seen, that will be our next major issue in terms of health and safety,” he says. Freedman says that most of these drugs are mailed here from China. “If you try to ship 40 pounds of marijuana, that’s going to raise some flags. If you ship 100 hits of a synthetic or LSD, it weighs as much as a sheet of paper, and it’s much easier to get that through the mail than a bulk of cocaine or marijuana,” says Freedman. “The ones that I’m concerned about are the ones where no one knows what the ingredient list is, except for the people who are making it.” Tabs of hallucinogens like LSD or 25 nbomb are less than one square centimeter and come on blotter paper or coated onto candy. Research chemicals like 25 n-bomb, on which you can overdose, are frequently sold as LSD, on which you cannot. Alex Carlson, who got the drug from friends, says: “You never really know precisely what you’re getting, and that’s a danger with liquid drugs.” Over the last few years, the Narcotics Task Force has busted 10 to 20 synthetic dealers. Dealers are generally white, college-aged, and male, he says. At the moment, the police are better at catching dealers of heroin than psychedelics. “It’s an iceberg,” says Freedman, using the example of MDMA, also known as ecstasy. “For every heroin dealer we catch there are 10 we don’t, and we’re looking for them. So for every MDMA intercept that happens, my experience says there are dozens and dozens, maybe scores, maybe hundreds, that we don’t.” “They’re only popular because everyone wants LSD,” says Alex, referring to his high school peers. “Everyone who has ever wanted to find LSD has taken them.” Alex estimates that up to 30% of Madison high school students have taken 25 n-bomb or another research chemical. Freedman thinks that’s an exaggeration and the number is closer to 5%. “If we’re talking just what they think is actual acid, or an acid analog, I would think it would be in single-digit percentages,” says Freedman. “As jaded and cynical as I am, I’d be surprised if 30% of high school kids are trying acid.” Freedman says Madison needs to be vigilant about hard drugs. “There’s more drug use in the United States per capita than any other country in the world, and [Madison is] reflective of that,” he says. “Hard drugs are like almost any hard crime — it doesn’t take very
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