Clonazepam: A Benzodiazepine As An AntiDepressant
Clonazepam is a benzodiazepine that affects chemicals in the brain that may be out of balance. Benzodiazepine that acts as CNS depressants, producing all its levels of depression. It’s so efficient as you can buy clonazepam online.
Indications ● ● ● ● ●
Lennox-Gastaut syndrome (a variant of Little Evil) Akinetic crisis Myoclonic seizures Crisis or seizures of absences (Little bad) Panic attacks.
Contraindications ● Hypersensitivity to clonazepam and benzodiazepine ● Narrow-angle glaucoma
Cautions ● When used in patients with mixed-type seizures, clonazepam may precipitate or increase the incidence of generalized tonic-clonic seizures. ● It can interfere with the motor and cognitive activity of the patients under treatment, it should be suggested to carry out with caution activities that require alertness (operating machinery, driving vehicles). ● Pregnancy: crosses the placental barrier; Recent reports indicate an increase in the incidence of congenital anomalies, it is suggested to assess the benefit-risk ratio during the first trimester of pregnancy. ● Its prolonged use can cause withdrawal syndrome and near the moment of delivery, flaccidity and depression of the newborn. Risk category: C. ● Breastfeeding: excreted in breast milk, can cause sedation and sucking disorders in the infant. In newborns, clonazepam is metabolized more slowly than in adults, and an accumulation of this can occur, which can cause sedation and weight loss in the newborn. ● Geriatric or debilitated patients, children, patients with renal or hepatic dysfunction, or with hypoalbuminemia should receive a reduced initial dosage since these patients have decreased elimination, which would produce an increase in side effects on the Central Nervous System.
â—? In respiratory failure and Chronic Obstructive Pulmonary Disease (COPD), they can depress respiration, so lower doses are required for these patients.
Adverse reactions Frequent Drowsiness, fatigue, ataxia and behavioural disorders.
Occasional Abnormal eye movements, nystagmus, diplopia, chorea, dysarthria, headache, hemiparesis, muscle hypotonia, jerky language, tremor, vertigo, confusion, constipation or diarrhoea, changes in libido, urinary retention, dry mouth, increased bronchial secretions, respiratory depression, hypotension, bradycardia. By sudden suppression (high doses for long periods): seizures, irritability, nervousness, sweating, abdominal pain, nausea and vomiting, hypersensitivity and pain, photophobia, tachycardia, delirium and paranoid symptoms.
Interactions A prescription like this brings always Clonazepam For Sale but the Alcohol and other depressants of the central nervous system (antihistamines, general anaesthetics and local parenteral, tricyclic antidepressants, baclofen, benzodiazepines, barbiturates, chloral hydrate, diphenoxylate-atropine, disulfiram, magnesium sulfate, meclizine, meprobamate, methyldopa, metoclopramide, analgesic opiates, paregoric, promethazine and others) can increase the depressant effects at the central level.
Carbamazepine and diphenylhydantoin: decrease the serum concentration of clonazepam. Simultaneous use of tricyclic antidepressants with clonazepam may decrease the seizure threshold and anticonvulsant effects.
How should I take clonazepam? Adults: initial dose: 0.5 mg, every 8 h, orally, can be increased from 0.5 to 1 mg, every 3d, until seizures are controlled or until adverse effects appear. The maintenance dose should be individualized, a maximum dose of 20 mg daily. Children: infants and children under 10 years of age weighing 30 kg: initial dose of 0.01-0.03 mg/kg / d (divided into 2 or 3 doses), with increments of 0.25-0.5 mg every 3 d until reaching the maintenance dose of 0.1-0.2 mg/kg / d, or that seizures are controlled or that adverse effects appear, the daily dose should be divided into 3 doses (if not divided into equal parts, the highest dose should be administered before sleeping at night).
Treatment of overdose and serious adverse effects General measures: if there is agitation, avoid barbiturates (they aggravate excitation and cause respiratory depression), in such cases, flumazenil (a specific benzodiazepine antagonist ) is recommended.
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