by chromogenex ™
FOR OVER TWENTY FIVE YEARS CHROMOGENEX HAS BEEN A WORLD LEADER IN LASER AND LIGHT AESTHETIC TREATMENTS
INTRODUCING REGENLITE Regenlite offers non-ablative skin treatment using the latest generation of laser technology and is the result of over ten years of research and practical experience in the medical and cosmetic sectors. Regenlite provides a fast, effective treatment for acne vulgaris together with skin rejuvenation and vascular treatments. with exclusive Smartpulse technology,
Regenlite stimulates the body’s natural responses to produce a new collagen or to alleviate skin problems. Regenlite is backed by extensive clinical research and practical experience from more than 500 aesthetic practices worldwide. With no need for cooling or anaesthesia and with little or no visible after-effects or recovery time it offers easy and convenient treatment options for patients and clinics.
THE REGENLITE TECHNOLOGY Regenlite can be used to stimulate collagen production and enhance skin rejuvenation by selectively targeting healthy dermal capillaries at sub-pupuric doses. Pulsed dye lasers were originally developed to destroy unwanted blood vessels that manifest in a variety of vascular irregularities. Treatments for these conditions typically involve a 450Âľs pulse duration, which delivers energy outside the thermal damage threshold for the target vessels. Regenlite has been engineered to deliver a patented short pulse where 80% of the supplies exactly the right amount of energy to the vessels at exactly the right time, taking them to the brink of damage and maximising collagen stimulation without causing long term impairment. Smartpulse technology has been developed for this purpose.
The Smartpulse is generated by a unique, ultra-stable laser cavity which produces the all-important fast rise pulse and pure 585nm yellow light. Research on the characteristics of oxyhaemoglobin has shown 585nm to be the perfect wavelength of light for maximising tissue penetration and absorption. Wavelength stability is crucial in order to maximise absorption and to minimise unwanted purpura. A 585nm wavelength also requires a lower energy level, is less painful and is more accurate in targeting the tissue zone for treatment. The effectiveness of the Regenlite treatment has been evaluated using biochemical analysis, electron microscopy histology, ultrasound imaging and clinical studies and has been described in Lancet publications and in The British Journal Of Dermatology. Electron microscopy work by Dr T Omi MD of Yokohama, Japan, shows the progressive, post-treatment production of new collagen
VERSATILE TECHNOLOGY PRACTICE APPEAL Using Regenlite is easy. Treatments can be delivered simply and quickly with minimal intra-operative discomfort or post-operative effects, enabling fast patient turn-around times to be achieved. The equipment is operated using touch-screen controls and an ergonomic hand-piece. Regenlite can be used to treat all grades of acne vulgaris together with skin rejuvenation, Vascular Treatment and Acne: Skin Rejuvenation Dermal re-modelling and skin tightening Reduction of lines and wrinkles Improvement of irregular pigmentation Collagen stimulation for traumatic or surgical scarring Eyelid lifts
Vascular Treatments Port-Wine stains Telangiectasia Angioma Warts and verrucae
Acne Actual acne all grades Acne scarring
Psoriasis Pigmentation
“Regenlite is the biggest breakthrough in the treatment of Acne Vulgaris in 20 years� Leading Consultant Dermatologist, Prof. Tony Chu
55 PERCENT 50 PERCENT REDUCTION IN.. REDUCTION IN.. Wrinkle depth
Acne lesion count
A single Regenlite treatment results in an 84 percent increase in Type III collagen production with a 5mm hand-piece. This rises to 99.5 percent increase in Type III
In tests on acne vulgaris a single Regenlite treatment results in a 50 percent reduction in average lesion count within two weeks of treatment. This gives lasting improvement up to and beyond twelve weeks after the single laser session and produces a 500 percent increase in TGFĂ&#x; in the dermis (3).
piece. Regenlite increases overall collagen laser session two weeks later and results in, on average, a 55 percent reduction in wrinkle depth after 90 days. Research was carried out at the University Hospital of Aarhus, Denmark. Ultrasound treatment highlights the dramatic remodelling in dermal collagen structure.
Research was carried out at Imperial College London and published in the Lancet and British Journal of Dermatology.
SKIN REJUVENATION: There is no better way of evaluating the success of the Regenlite product than through physical evidence of its use. Here are some examples.
Before treatment
After 4 treatments
Before treatment
After 4 treatments
Before treatment
After treatment
Before treatment
After treatment
Before treatment
After 3 treatments
ACNE/ ACNE SCARRING:
Before treatment
After 2 treatments
Before treatment
After 2 treatments
Before treatment
VASCULAR/ WARTS:
Before treatment
After 6 treatments
Before treatment
Before treatment
After 5 treatments
HOW IT WORKS rejuvenation and acne reduction is simple and well-proven.
TGFß is known to provide a potent stimulus for neocollagenesis and a pivotal immuno-suppressive cytokine. The combined
the microvasculature of the dermis and to stimulate the tissue’s natural wound-healing response without any residual cell necrosis. When the Regenlite laser beam targets a small capillary, absorption by the oxyhaemoglobin results in mild heating of the capillary walls.
resolution within early acne lesions and to prevent microcomedone formation, which occurs as a result of keratinocyte hyperprofoliation at the pilosebaceous unit.
that produce new collagen. Unlike other treatments, which use indirect methods to produce collagen and cause dermal wounds, Regenlite works from the ‘inside out’ to and the production of collagen without The release of these molecules – in particular TGFß – is also responsible for the unique treatment results which have been achieved
More important is the association of TGFß to acquired immunity within the tissue, which prevents microcomedone formation in the future and provides durable results from a single laser treatment. Typically patients can remain acne-free after just two or three laser sessions and occasional maintenance. Regenlite’s ability to produce a stable, even 585nm wavelength beam of laser light generated is crucial to the effectiveness wavelength makes a 300% reduction in the absorption rate in oxyhaemoglobin.
Energy
TWO MODES OF OPERATION
F1
Dye Cell
F2
Regenlite Smartpulse Traditional PDL Pulse
F4
H20 Coolant
remodelling, skin rejuvenation, acne and acne scarring
F3
Energy
of vascular lesions pigmentation and wart removal
Time
Target capillaries for stimulation of collagen
Regenlite Smartpulse Traditional PDL Pulse
A pure 585nm laser 300% more absorption in Oxyhaemoglobin than 595nm. It is critical for clinical results that the wavelength remains 585nm.
Target vessels for vascular damage
Time
EXTENSIVE STUDIES 3hrs Post
2 Weeks Post
4 Weeks Post
5 Weeks Post
Courtesy of Dr T. Omi, M.D. Yokohama, Japan Swollen Capillary With marked oedema
Normal Capillary
New Elastic Fibres Mast Cell
Biochemical Analysis Prof. Peter Bjerring, M.D. Marselisborg Hospital, Aarhus, Denmark
EXTENSIVE RESEARCH The Lancet
87% of patients had a substantial improvement 58% had greater than 50% improvement The most rapid improvements There were no reported side effects.
“Over 92% of patients reviewed after a single treatment had a of patients had a 50% reduction in lesions after a single treatment.�
Pulsed-dye laser treatment for inflammatory acne vulgaris: randomised controlled trial
LANCET VOL. 362
Saturday 25 October 2003 Vo l . 3 6 2 N o . 9 3 9 3 Pages 1347 -1352
RESEARCH RESULTS British Journal of Dermatology at Imperial college to look at the pathogenesis of acne shown some
20MegaHz ultrasound images showing result of laser: Before
increased quantities
After 30 days 2000
1500
1000
500
0
Baseline
Courtesy of George J. Hruza, MD. Laser & Dermatologic Surgery Centre,
3 Hours
24 Hours
modulates the bodies immune response
WHY REGENLITE?
WHAT THE EXPERTS SAY “The most versatile laser you will ever purchase” Dr Shapiro, Florida, USA.
“The biggest breakthrough in Acne in the last 30 years” Prof. Chu, Hammersmith Hospital, UK.
“Better results than my fraxel but without the side effects” Dr. Kopleston, LA, USA.
TECHNICAL SPEC WAVELENGTH PULSE DURATION: DELIVERY SYSTEM: MODE STRUCTURE: SMARTRIDGE® LIFE: AIMING BEAM: REPETITION RATE: SPOT SIZE: ELECTRICAL REQUIREMENTS: COOLING REQUIREMENTS: SAFETY:
USER INTERFACE: SYSTEM STATUS & FAULT DIAGNOSTICS:
585nm Up To 450µs FWHM (Vascular) Flexible Optical Fibre Top Hat, ±2% of Mean Monitored by intelligent computer system, with life warning Slow, medium, fast 220V AC @ 24A 60Hz or 230V AC @ 20A 50Hz Single Phase Self contained, de-ionised water-cooled integral Chiller Class 4-Laser Product Electrical Class I, BF type, stationary equipment CE approvals On board computer based self-diagnostics Colour LCD for User Instructions Touch Screen Input Interface Autocalibration system for accurate energy to tissue calibration Internal Energy Meter with display of energy density On board computer based self-diagnostics
ENVIRONMENTAL REQUIREMENTS: DIMENSIONS: WEIGHT: EQUIPMENT INCLUDED: Case OPTIONAL ACCESSORIES:
Laser Training Course, Surgical handpiece
The Company
Contact us
Chromogenex Technologies Limited has been
All email enquiries to: sales@chromogenex.com www.chromogenex.com www.regenlite.com
During this time it has grown from a manufacturing and repair service to a global business offering expertise in clinical training, customer support, design and development, manufacturing and research.
Chromogenex Technologies Ltd. United Kingdom
Commitment to Quality Chromogenex devices are designed and manufactured in the United Kingdom and meet all product, system and regulatory requirements for a worldwide market. Chromogenex applies a Medical
United States Chromogenex US Inc. 5896 Sterling Drive, Howell, MI 48843
Device Directives, United States FDA and GMP, and Canadian Medical Device Regulations.
OR DE M E PR O
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Phone: All other international enquiries: +44 (0)1554 755 444 Made in Great Britain.