UIC Bioengineering Annual Report 2015-2016

ANNUAL REPORT 2015-2016

IN THE ISSUE

Message from Department Head Faculty Research Funding Enrollment Student Chapters Book Review Seminar Series UIC Bioengineering Student Journal Bioengineering Experience for Science Teachers Guaranteed Internship Program Clinical Immersion Internship Senior Design Expo

Institute for Biomaterials, Tribocorrosion, and Nanomedicine Microfabricated Tissue Models Laboratory In-Situ Nanomedicine Laboratory Cell Mechanics and Signaling Laboratory for Neurodegenerative Diseases Bioengineering Industry Day Faculty News Student News Archival Journal Publications 50 Years UIC Bioengineering

MESSAGE FROM DEPARTMENT HEAD

Dear Friends of the UIC Richard and Loan Hill Department of Bioengineering, For the past five years we have published two newsletters, Fall and Spring, highlighting recent activities. These are archived on our website at “Newsletter” under the “About us” link. This is our first annual report providing more detail on activities and accomplishments of our students, staff and faculty over the past year, including this past summer.

While we continue to move forward with expanding undergraduate and graduate programs, new educational initiatives involving the UIC Medical School, College of Engineering and Innovation Center, new faculty hires and research projects, we also took some time this past year on our 50th anniversary to look back and recognize those who came before us at UIC, pioneers of the exciting new field of bioengineering.

We commemorated their contributions to the field through a symposium held this past Fall, highlights of which have been published in a special issue of “Critical Reviews in Biomedical Enginneering”. We are now continuing with live interviews of our founding faculty and students that will become part of a dedicated website we plan to launch later this year. My predecessor as department head and mentor, University Distinguished Professor Richard L. Magin, has been leading this effort. More information about this endeavor and many other exciting developments can be found inside.

As always, thank you for helping support our continued pursuit of excellence. Gifts targeted to the department continue to help us achieve our strategic goals, and could include opportunities to endow a named professorship, scholarship, laboratory, or special facility or program. Recently, with your generous support to the department we have been able to increase the number of scholarships we can offer to deserving incoming undergraduates. For more information on giving see “Give to BioE” under “About us” on our website. In addition to financial support, I know that the network of UIC BioE alumni and friends will continue to help our students find internship and employment opportunities. Perhaps you would like to participate in our next Bioengineering Industry Day, tentatively scheduled for November 18, 2016? (Learn about it inside.) I am always happy to meet our alumni and friends and welcome your visit. And, please join our Facebook group; see the link on the cover.

Best wishes for a great new school year,

Thomas J. Royston

CORE FACULTY Jun Cheng, PhD

Dieter Klatt, PhD

Live-cell imaging, Ultrafast laser microsurgery, Stem cell regulations.

Email: juncheng@uic.edu

Elastography, MRI, Motion-sensitive imaging Email: dklatt@uic.edu

Assistant Professor

Assistant Professor

Yang Dai, PhD

Miiri Kotche, PhD

Associate Director of Graduate Studies Bioinformatics Email: yangdai@uic.edu

Interdisciplinary medical product development (IMPD), Senior design, Global health Email: mkotch2@uic.edu

Associate Professor

Clinical Associate Professor

Urmila Diwekar, PhD

Mrignayani Kotecha, PhD

Stochastic Modeling, Optimization Uncertainty Email: urmila@uic.edu

Biomedical Imaging Email: mkotecha@uic.edu

Professor

Research Assistant Professor

David Eddington, PhD

Terry Layton, PhD

Microfluidics Email: dte@uic.edu

Senior design, Medical device design, FDA regulations.

Email: tnl@uic.edu

Hananeh Esmailbeigi, PhD

James Lee, PhD

Associate Professor, Director of Graduate Studies

Clinical Assistant Professor, Associate Director of Undergraduate Studies

Neural and biological signal processing, Bioinstrumentation Email: hesmai2@uic.edu

Senior Lecturer

Associate Professor

Alzheimer’s disease, Membrane physics, Cell Signaling Email: leejam@uic.edu

John R. Hetling, PhD

Alex Leow, MD, PhD

Electrophysiology of vision, Functional im aging Email: jhetli1@uic.edu

Neural Imaging Email: aleow@psych.uic.edu

Associate Professor, Director of Undergraduate Studies

Associate Professor of Psychiatry and Bioengineering

Salman Khetani, PhD

Xue-Jun Li, PhD

Tissue engineering, Biomaterials, Micro-fabrication & Micro-fluidics, Liver physiology, Drug development Email: skhetani@uic.edu

Stem cells, Neural development and degeneration Email: xjli23@uic.edu

Associate Professor

Associate Professor

2

Jie Liang, PhD

Mathew T. Mathew, PhD

Bioinformatics, Computational systems biology Email: jliang@uic.edu

Corrosion and tribocorrosion aspects of implant bio-materials in dentistry and orthopaedics Email: mtmathew@uic.edu

Richard and Loan Hill Professor

Associate Professor

Andreas Linninger, PhD

Craig Niederberger, MD

Drug delivery, Hemodynamics of the brain, Metabolic engineering, Bioprocess design, Biomechanics Email: linninge@uic.edu

Urology Email: craign@uic.edu

Professor

Professor of Urology and Bioengineering

Hui Lu, PhD

Jose Oberholzer, MD

Bioinformatics, Computational proteomics Email: huilu@uic.edu

Surgery, Transplantation Email: jober@uic.edu

Associate Professor

Professor of Surgery and Bioengineering

Cristian Luciano, PhD

William O’Neill, PhD

Haptic virtual reality, Surgical simulation Email: clucia1@uic.edu

Neuroscience, Pupillography Email: woneill@uic.edu

Research Assistant Professor

Professor

Ao Ma, PhD

Ian Papautsky, PhD

Bioinformatics, Microtubules dynamic modeling Email: aoma@uic.edu

Point-of-Care Electrochemical Sensors, Inertial Microfluidics Email: papauts@uic.edu

Associate Professor

Professor

Richard Magin, PhD

James Patton, PhD

MRI, Targeted drug delivery, Bioelectromagnetics Email: rmagin@uic.edu

Robotics for therapeutic neuro-rehabilitation, Haptics, Human-machine interfaces, Neural control Email: pattonj@uic.edu

University Distinguished Professor

Professor

G. Ali Mansoori, PhD

Richard Penn, MD

Nanotechnology, Thermodynamics Email: mansoori@uic.edu

Neurological diseases, Hydrocephalus, Drug delivery, Neurological imaging

Professor

Professor

Email: rpenn@uic.edu

AFFILIATED Thomas Royston, PhD

Professor and Department Head

Biomedical acoustics, MR elastography Email: troyston@uic.edu

Jae-won Shin, PhD

Assistant Professor of Pharmacology and Bioengineering Tissue engineering, Stem cell biology Email: shinjw@uic.edu

Tolou Shokuhfar, PhD Associate Professor

Nanotechnology and nanomedicine, Orthopedic implants Email: tolou@uic.edu

Michael Stroscio, PhD

University Distinguished Professor

Nanobiotechnology, Nanoelectronics, Integrated bio-nano complexes Email: stroscio@uic.edu

Christos Takoudis, PhD Professor

Biomaterials and nanotechnology, Chemical and biochemical interfacial engineering Email: takoudis@uic.edu

Daniela Valdez-Jasso, PhD Assistant Professor

Soft-tissue biomechanics, Cardiovascular physiology, Pulmonary hypertension Email: dvj@uic.edu

Xincheng Yao, PhD Professor

Biomedical optics instrumentation, Optical imaging of retinal function Email: xcy@uic.edu

Zhuming Ai, PhD Dept/Company: Biomedcal Health Information Belinda Akpa, PhD Dept/Company: Chemical Engineering Kenneth Alexander, PhD Dept/Company: Ophthalmology & Visual Sciences Farid Amirouche, PhD Dept/Company: Mechanical Engineering Robert Anderson, PhD Dept/Company: Rush OB/GYN Gunnar Andersson, MD, PhD Dept/Company: Rush Orthopedics Anjum Ansari, PhD Dept/Company: Physics Alexander Aruin, PhD Dept/Company: Physical Therapy Boaz Avitall MD, PhD Dept/Company: Cardiac Electrophysiology Dimitri Azar, MD, MBA Dept/Company: Ophthalmology & Visual Sciences Amelia Bartholomew MD, MPH, FACS Dept/Company: Surgery William Beck, PhD Dept/Company: Biopharmaceutical Sciences Anakarina Bedran-Russo, PhD Dept/Company: Dentistry Tanya Berger-Wolf, PhD Dept/Company: Computer Science Dulal Bhaumik, PhD Dept/Company: Epidemiology & Biostatistics Alan Boghosian, DDS Dept/Company: Northwestern University Dental School Scott T Brady, PhD Dept/Company: Anatomy and Cell Biology Kenneth Brezinsky, PhD Dept/Company: Industrial Engineering Elisa Budyn, PhD Dept/Company: Mechanical & Industrial Engineering Kejia Cai, PhD Dept/Company: Radiology David Carley, PhD Dept/Company: Medicine Sabri Cetinkunt, PhD Dept/Company: Mechanical & Industrial Engineering Donald Chambers, PhD Dept/Company: Biochemistry Michael Cho, PhD Dept/Company: UT Arlington Daniel Corcos, PhD Dept/Company: Northwestern University Bhaskar Das Gupta, PhD Dept/Company: Computer Science Pieter de Tombe, PhD Dept/Company: Loyola Physiology John Daugirdas, PhD Dept/Company: Medicine Thomas Diekwisch, DMD, PhD Dept/Company: Orthodontics

4

AFFILIATED Carmen DiGiovine, PhD Dept/Company: 6 Degrees of Freedom, LLC Carla Evans, DDS Dept/Company: Orthodontics Christopher Fall, PhD Dept/Company: Georgetown Computer Science Alan Feinerman, PhD Dept/Company: Electrical and Computer Engineering Douglas Feinstein, PhD Dept/Company: Anesthesiology Jesus Garcia-Martinez, MD, PhD Dept/Company: Physiology & Biophysics Richard Gemeinhart, PhD Dept/Company: Pharmaceutics / Pharmacodynamics Anne George, PhD Dept/Company: Oral Biology Ben Gerber, MD Dept/Company: Medicine Maryellen L. Giger, PhD Dept/Company: University of Chicago, Radiology Mark Grabiner, PhD Dept/Company: Kinesiology Oliver Graudejus, PhD Dept/Company: Princeton Physiology Daniel Graupe, PhD Dept/Company: Electrical and Computer Engineering Anil Gulati, PhD Dept/Company: Midwestern University Pharmacy Ogan Gurel, PhD Dept/Company: Aesis Research Group Nadim Hallab, PhD Dept/Company: Rush Orthopedics Luke Hanley, PhD Dept/Company: Chemistry Glenn Hedman, MS Dept/Company: Disability and Human Development Daniel Hier, MD Dept/Company: Neurology Seungpyo Hong, PhD Dept/Company: Biopharmaceutical Sciences Anton J. Hopfinger, PhD Dept/Company: Medicinal Chemistry Constance Jeffery, PhD Dept/Company: Biological Sciences Michael Johnson, PhD Dept/Company: Pharmaceutical Biotechnology Greg Jursich, PhD Dept/Company: Bioengineering Lon Kaufman, PhD Dept/Company: Biological Sciences Robert Kenyon, PhD Dept/Company: Computer Science Timothy Koh, PhD Dept/Company: Kinesiology Prakash Kotecha, PhD Dept/Company: Vishwamitra Research Institute Mary Jo Ladu, PhD Dept/Company: Anatomy & Cell Biology Andrew Larson, PhD Dept/Company: Northwestern University

Irena Levitan, PhD Dept/Company: Pulmonary, Critical Care, Sleep Medicine Fei Li, PhD Dept/Company: Pharmacology Jianxun Li, PhD Dept/Company: Oral Biology Qingbo Li, PhD Dept/Company: Pharmaceutical Biotechnology Aiming Lu, PhD Dept/Company: MR Research Center Nadim Mahmud, PhD Dept/Company: Medicine Asrar Malik, PhD Dept/Company: Pharmacology Natalia Maltsev, MD, PhD Dept/Company: University of Chicago Hansen Mansy, PhD Dept/Company: University of Central Florida Jeremy Mao, PhD Dept/Company: Columbia University Medical Center Phillip Marucha, DMD, PhD Dept/Company: Periodontics Farzad Mashayek, PhD Dept/Company: Mechanical &Industrial Engineering J. Jason McAnany, PhD Dept/Company: Ophthalmology & Visual Sciences Irving Miller, PhD Dept/Company: Chemical Engineering David Mogul, PhD Dept/Company: IIT Biomedical Engineering Pirooz Mohazzabi, PhD Dept/Company: Univeristy Wisconsin Parkside Raghu Natarajan, PhD Dept/Company: Rush Hammad Naveed, PhD Dept/Company: Toyota Technological Institute at Chicago S. Jay Olshansky, PhD Dept/Company: Epidemiology and Biostatistics Steven Olson, PhD Dept/Company: Oral Diseases Hayat Onyuksel, PhD Dept/Company: Pharmaceutics Alejandro Espinoza Orias, PhD Dept/Company: Rush Marc Ovadia, MD Dept/Company: University of Chicago Clive Pai, PhD Dept/Company: Physical Therapy Philip Patston, PhD Dept/Company: Oral Medicine Avinash Patwardhan G, PhD Dept/Company: Edward Hines Jr. VA Hospital, Loyola University Stritch School of Medicine Dan Pavel, PhD Dept/Company: Radiology / Nuclear Medicine David R. Pepperberg, PhD Dept/Company: Ophthalmology Pavel Petukhov, PhD Dept/Company: Medicinal Chemistry & Pharmacognosy William Pietrzak, PhD Dept/Company: Biomet, Inc

AFFILIATED Stephen W. Porges, PhD Dept/Company: Psychiatry Kim Reisinger, PhD Dept/Company: Ctr. for International Rehabilitation Susan Renner, PhD Dept/Company: Hines VA Hospital Brian Roman, PhD Dept/Company: University of Chicago Patrick Rousche, PhD Dept/Company: Ensis Scientific Consulting Charles Rhodes, PhD Dept/Company: Physics Brenda Russell, PhD Dept/Company: Physiology & Biophysics Aheda Saber, PhD Dept/Company: Governors State University Juan Salazer, PhD Dept/Company: KSU Chemical Engineering Patrick Salmon, PharmD, PhD Dept/Company: Neurosciences, Geneva School of Medicine (CMU) Hee-Jeong Sampen, PhD Dept/Company: Rush Biochemistry Laxman Saggere, PhD Dept/Company: Mechanical & Industrial Engineering Dan Schonfeld, PhD Dept/Company: Electrical and Computer Engineering Joel Schwartz, DMD, DMSc Dept/Company: Oral Medicine Stanley Sclove, PhD Dept/Company: Information & Decision Sciences Michael Scott, PhD Dept/Company: Mechanical & Industrial Engineering Kotaro Sena, PhD Dept/Company: Rush Anatomy & Cell Biology Ahmed Shabana, PhD Dept/Company: Mechanical & Industrial Engineering Mahnaz Shahidi, PhD Dept/Company: Ophthalmology Sadhana Sharma, PhD Dept/Company: Ohio State University Scott Shippy, PhD Dept/Company: Chemistry Brenda Sposato, MEBME, ATP Dept/Company: Assistive Technology Glenn Stebbins, PhD Dept/Company: Rush Neurological Sciences Rick Sumner, PhD Dept/Company: Rush Anatomy & Cell Biology Janet Szlyk, PhD Dept/Company: Ophthalmology & Visual Sciences Peter Tek, MS, DO Dept/Company: Midwestern University Keith Thulborn, MD, PhD Dept/Company: MR Research Center Joseph Towles, PhD Dept/Company: Rehabilitation Institute of Chicago Matthew Tresch, PhD Dept/Company: Northwestern University Karen Troy, PhD Dept/Company: Worcester Polytechnic Institute

David Ucker, PhD Dept/Company: Microbiology & Immunology Amarjit Virdi, PhD Dept/Company: Rush Anatomy & Cell Biology Vincent Wang, PhD Dept/Company: Virginia Tech Kishore Wary, PhD Dept/Company: Pharmacology Jamie Williams, PhD Dept/Company: Robson Forensic Markus Wimmer, PhD Dept/Company: Rush Orthopedics Shaolin Yang, PhD Dept/Company: Psychiatry, Radiology X. Joe Zhou, PhD Dept/Company: MR Research Center Bert Zuber, PhD Dept/Company: Professor Emeritus

Clinical Associate Professor Miiri Kotche, recipient of the Association for Women in Science (AWIS) Chicago Region 2016 Motivator of the Year Award

The Award was bestowed at a recognition banquet held at Athena Restaurant in Greektown on July 14. Here Dr. Kotche is seen with Karen Chien, outgoing president of AWIS Chicago.

From left to right: Marina Damiano (newly appointed president of AWIS Chicago), Sarayu Ratnam (VP for Outreach), Barbara Di Eugenio (VP for Finance and UIC Professor of Computer Science), Miiri Kotche, Karen Chien, Ana Shulla (VP for Communication), Amy Barry (VP for Membership)

6

RESEARCH FUNDING NATIONAL INSTITUTES OF HEALTH (NIH) PI (Co-I’s in the Dept) Jose Oberholzer

(David Eddington)

Salman Khetani

(David Eddington)

Salman Khetani Miiri Kotche Miri Kotche

TITLE OF PROJECT

PERIOD

AMOUNT

A Novel Beta Cell Specific Microfluidic Perfusion and Imaging Device for Islet Potency Testing Engineering Zonal Human Liver Functions in Vitro Using Microfluidics

9/1/2011-6/30/2016

$1,657,000

8/16/2015-6/30/2016

$158,865

12/01/14-11/30/2016

$150,000

1/1/2016-12/31/2020

$539,177

1/1/2016-12/31/2020

$215,840

Exploring HCV Infection in Engineered Cultures of iPSC-Derived Human Liver Bioengineering Summer Research Experience for High School Teachers Translational Design of Medical Devices

James Lee

Cytosolic Phospholipase A2 in Amyloid-Beta Peptide-Stimulated Cerebral Endothelium

5/1/2014 - 4/30/2019

$1,538,304

Jie Liang

Computational Assembly of Beta Barrel Membrane Protein

9/1/2013-8/31/2017

$1,200,000

Ao Ma

Determining the spindle dynamics regulatory network with an integrated approach

9/30/2010-8/31/2016

$1,551,920

James Patton

Error Enhanced Learning and Recovery 2 and 3 Dimensions

7/1/2013-6/30/2018

$1,600,000

Thomas Royston

Noninvasive tools for assessing muscle structure and function (Sub-

8/01/16-7/31/21

$700,000

Thomas Royston

The Audible Human Project

Xincheng Yao

Super Resolution Opthalmoscopy For In Vivo Retinal Imaging

Xincheng Yao

Functional Imaging of Retinal Photoreceptors

(Dieter Klatt, Richard Magin) contract through NU)

9/01/2010 – 8/31/2015

$1,310,440

5/1/2015-8/31/2017

$1,044,860

4/1/2015-3/31/2019

$1,727,050

NATIONAL SCIENCE FOUNDATION (NSF) TITLE OF PROJECT

PERIOD

AMOUNT

David Eddington

IDBR-B - Precise Oxygen Landscapes for Cells and Tissues in Culture

6/1/2013-5/31/2016

$597,850

David Eddington

EAGER Collaborative Proposal A Microfluidic Platform for the Disco very of New Life like Chemical Systems Inthrathecal Magnetic Drug Targeting To The Central Nervous System With Superparamagnetic Nanoparticles EAGER: Computational Investigation of the Distributed Decentralized Control of Cerebral Blood Flow RET in Engineering and Computer Science Site Chicago Science Teacher Research CSTR Program Using Empirical and Mathematical Approaches to Model Yeast Gradient Sensing CAREER Towards a Stem Cell-Derived 3D Human Liver Array for High-Throughout HCC Medium Collaborative Research Force Feedback for Fingertips

8/1/2016-7/31/2018

$150,000

5/1/2014-4/30/2017

$310,848

1/1/2013-12/31/2015

$94,000

4/1/2012-3/31/2016

$499,433

8/1/2014-7/31/2018

$204,109

7/1/2014-3/31/2019

$405,886

6/1/2013-5/31/2017

$399,669

9/1/2014-6/30/2019

$400,000

9/1/2013-8/1/2016

$119,738

8/1/2011-7/31/2016

$400,000

PI (Co-I’s in the Dept)

Andreas Linninger Andreas Linninger Andreas Linninger Jie Liang (Co-I) Salman Khetani Thomas Royston (Dieter Klatt) Tolou Shokuhfar Christos Takoudis Xincheng Yao

CAREER A New Perspective on Biomineralization in Healthy and Dysfunctional Ferritins Computational Design and Atomic Layer Deposition Synthesis of Stereochemically Active Multifunctional Oxicle Nanostructures CAREER Simultaneous imaging of photoreceptor and post-photoreceptor responses in the retina

OTHER AGENCIES AND INDUSTRY PI (Co-I’s in the Dept)

TITLE OF PROJECT

PERIOD

GRANTING AGENCY

AMOUNT

Daniela Valdez-Jasso

Ventriculo Vascular Coupling in PAH Significance of Large Vessel Remodeling on Cardiac and Pulmonary Vascular Multi Objective Optimal Sensor Deployment Under Uncertainity For Advanced Power Systems New Approaches and Routes to Battle Neurodegenerative Disorders Promoting Healing of Tendinopathies Using Therapeutic Mechanobiologic Stimulation for Targeted Removal of Aggrecan-Rich Deposits All Printable Real Time Airframe Monitoring Systems ARAMS

7/1/2016-6/30/2019

AHA

$228,323

9/1/2013-8/31/2016

US Dept of Energy

$300,000

2/16/2016-2/15/2017

$168,957

1/1/2016-12/31/2016

USA Prime Business LLC VATech

2/24/2015-9/12/2017

ARAMS

$110,552

AHA

$52,000

Urmila Diwekar Megha Agrawal Thomas Royston Gregory Jursich Paras Parikh Richard Magin

A Geometric Based Estimation Of Atrial Wall Stress For 7/1/2014-6/30/2016 the Prediction Of Remodeling In Patients With Atrial Fibrillation Orthopaedic Research Fund 8/16/2015-8/15/2016 10/01/2012-9/30/2018

James Patton

Machines Assisting Recovery From Stroke And Spinal Cord Injury For Reintegration Into Society

Tolou Shokuhfar

9/1/15-8/31/17 Direct Observation of Fiber Fluid Hygrophobic Interactions with Liquid Cell TEM Bacteria-Surface Adhesion Interactions: New Perspec- 8/15/2016-8/14/2019 tives in Antifouling Surface Design 2/1/2016-1/31/2017 Network Models of Rat Liver and Kidney Metabolism for Toxicology Predictions

Tolou Shokuhfar Salman Khetani

NIH $13,393,456

$35,539

Rush

$51,218

NIDRR

$5,700,000

Nonwovens Institute Nonwovens Institute University of Virginia

$79,513

NSF

OTHER

$3,581,533

$6,930,095

$164,106 $39,887

$23,905,084 in active research grants in AY 2015-2016 8

ENROLLMENT

DEGREES AWARDED (2009-2016) PHD

23 18

18

16

7

7

6

11

10

2009-10

Female Male

11

11

12

11

11

11

4

4

5

7

7

6

2010-11 2011-12 2012-13 2013-14 2014-15 2015-16

MS

33 21

12

15 3

7

12

17

16

10

13

9

8

12 4

26 11

18

5

Female Male

15

7

2009-10 2010-11 2011-12 2012-13 2013-14 2014-15 2015-16

BS

57 51

33 19

36 14

22

39

40

13

14

26

26

24

33

14

37

Female Male

46 12

34

14 2009-10 2010-11 2011-12 2012-13 2013-14 2014-15 2015-16

TOTAL POPULATION FOR FALL 2009

TOTAL POPULATION FOR FALL 2016 PHD (96)

PHD (106) BS (186)

BS (306) MS (49)

MS (74)

Institute for Biomaterials, Tribocorrosion, and Nanomedicine (IBTN) In 2012, Drs. Christos Takoudis, Tolou Shokuhfar, Mathew Mathew and Cortino Sukotjo together founded the Institute for Biomaterials, Tribocorrosion, and Nanomedicine (IBTN) which has two branches: A US branch and a Brazilian branch (co-founded by Dr. Luis Rocha from Universidade Estadual Paulista (UNESP)). IBTN serves as a research and educational institute with its main focus on the research and teaching related to the development and characterization of biomaterials for clinical applications. The team consists of clinicians, material scientists and engineers from bioengineering, chemical engineering and restorative dentistry at the University of Illinois at Chicago (UIC), Orthopedics at Rush University Medical Center (RUMC) and UNESP and Instituto Nacional de Metrologla (INMETRO) in Brazil with more than 15 universities involved as associate members of the Brazilian branch of IBTN. IBTN’s Mission is to contribute to the advance of scientific knowledge in biomaterials (development, surface modifications and characterization) for versatile clinical applications for generating and maintaining implants with required durability and multifunctional performance. IBTN aims to be a leading research institute in the area of biomaterial and bioengineering for multifunctional, durable and safer implants in the health care sector, particularly in dentistry and orthopedics. Currently, IBTN researchers meet on a weekly basis to discuss findings from the ongoing projects.

Each year, within its mission and vision, IBTN holds a symposium that is free and open where invited speakers and IBTN members present their research and discoveries. IBTN students are heavily involved in organizing the event. IBTN symposia are supported by Bioengineering and Dentistry at UIC and sponsored by TMJ Concepts, UIC-Office of International Affairs, ORAL-B, College of Dentistry, UIC, DUCOM Instruments and Springer. This year on Friday, February 19, 2016, IBTN held its 3rd international symposium at the UIC-College of Dentistry, which was attended by about 50 researchers from different universities in the Chicago area and a team from IBTN - Brazil. The opening ceremony started with remarks by Dr. Thomas Royston, Head of UIC Bioengineering, Dr. Stephan Campbell, Head of Restorative Dentistry at UIC-COD, Dr. Ramaswamy Kalyanasundaram, Chair of Biomedical Science, UI-School of Medicine, Rockford, and Dr. Markus Wimmer, Associate Chair of Research, Rush University Medical Center, Chicago. The symposium was followed by 11 invited lectures given by researchers from the UIC College of Engineering, College of Medicine, College of Dentistry, Rush Orthopedics, INMETRO, and the State University of Sao Paolo; the IBTN student members presented their research posters and participated in the student poster competition. In 2016, the winners of the student competition were Sweetu Patel (PhD Candidate, Advisor Dr. Tolou Shokuhfar), and Luciana Trino (PhD Student, Advisors, Drs Mathew Mathew and Paulo Filho (UNESP-Brazil)). The IBTN team is looking forward to seeing enhanced participation from bioengineering faculty and students in the next IBTN symposium (early in 2017).

For more details please see: http://ibtn.lab.uic.edu/. Email contact: ibtn.usa@gmail.com

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GRADUATES 2015-2016 DOCTORAL Moria Fisher Bittmann

Joseph R Lancaster

Customized Robotic Training Approaches Using the Statistics of Reaching Errors

Identification of Motor Impairments Using Movement Distributions

Matthew Adam Bochenek

Biswajit Maharathi

Immuno-Isolation Strategies for Islet Transplantation into Rodent and Non-Human Primate Models

Non Stochastic Propagation of Interictal Spikes as a Measure of Human Brain Connectivity

Diana Gutierrez

Carlos Francisco Ng Pitti

The Study of Non-Viral Nanoscale Delivery Systems for Islet Transplantation

Characterization Of A Microfluidic Bubble Removal System Using A Converging-Diverging Nozzle

Justin Horowitz

Abdul Rahman A, Abutaleb

Movement Intent and Its Construction

Saeed Khayatzadeh

Effect of Sagittal Malalignment on Cervical Spine Biomechanics

Gerardo Mauleon Ramos

3D Oxygen Microfluidic Platform for In Vitro Hypoxic Studies

Xenia Meshik

Quantum Dot- and Aptamer-Based Nanostructures for Biological Applications

Mohammad Nourmohammadzadeh

Application of Microfluidics in the Field of Diabetes and Islets

Ke Tang

Efficient Biased Sampling Methods for Biomacromolecules: Protein Loops and RNA Thermodynamic Prediction

Katie Josephine Trella

Hypoxia in Tendinopathies: From Epigenomics to Chondroid Metaplasia

Julia Zelenakova

Effect of Binge Alcohol Exposure on Intervertebral Disc Structure and Mechanical Properties in Adult Rats

MASTER’S

Sithichai Chaichanavitchakij

Comparison of Lumbar Disc Degeneration, Fusion and Disc Arthroplasty on Biomechanics of Adjacent Segment

Hemanti R Chavada

In Vitro Magnetic Resonance Assessment of Tissue Engineered Bone and Cartilage

Tanvishri Jatla

A Non-Invasive Method for Tracking Retinal Motion During Pars Plana Vitrectomy

Johnwesly A Kanagaraj

Cellular Reparative Effects of Poloxamer P188 in Blunt Force Trauma to Brain Tissue

David Zumba

Haptic Simulation of Prostate Cancer Based on Magnetic Resonance Elastography

Predictors Of Outcomes And Cost After Spinal Fusion Surgery And Construction Of Patient Risk Calculators

Esther Jeeyoung Shin

Characterizing the Parameter Space of an Oxygen Gradient between Hypoxic and Normoxic Gas Networks

Michael R Tan

Movement Learning With Isometric Training Through Virtual Reality

Mengqi Xing

Connectome Analyses of Functional Brain Networks in Patients with Psychiatric Disorders

Undarmaa Bat-Erdene Lauren Ann Curie Pratik Dilip Chaudhari Shweta Gopaulakrishnan Palash Jha Elena M Kulikova Mounika Reddy Kata Jarrett A Mickens Pooja Neogi Yahia Zakaria Rawash Catherine Santis James B Steele Martin J Strama Faisal M Waseem

BACHELOR’S Ahmad Khaled Abualleil Nathan J Albaugh Ossama Anis Wali Badar Genesis A Contreras Samuel John Dreyer Ramon A Espino Jesse W Gerringer Gizzel Gomez Erik A Gottardo Richard James Hickey Mark Edward Hillstrom Nazir S Hussain Mohammed Said Hussein Jagan Jimmy Christine R Joseph Raihaan Khan Sharif Kurdi Gary L Ling Mark Lopez Natalia E Lyda Jeff F Marsh Michael S Moauro Marisol Montoya Mananga Mutombo Lavanya Nese Michael J Oneill Marianne B Palczewski Arjav M Patel Binit Nitin Patel Tirth S Patel Ray Pizarro Jaskaran S Rajput Gregory R Roytman Namrata Saha Raaed Shaban Kyle S Sierzega Lovepreet Singh Nirav D Soni Adithyan Subramanian Steven C Taylor Dan Andrei Gloda Teleron Julie Catherine Wagner Jinying Weng Taiylar Jordane White Tiana Jasmine Wong

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STUDENT CHAPTERS

Engineering World Health (EWH) The past six months have signaled an immensely progressive time for our organization as a whole. As members of the board, we have been hard at work re-establishing our goals and focusing on expanding our reach - both in terms of our projects and the involvement of our members.

One of our projects, the laminar flow hood, has developed from a concept on paper to a complete operational product. The hood was constructed with the goal of reducing the infection rate of a pediatrics hospital our organization visited in Vietnam.

Over the past couple of months, we are working with UIC machine/electrical shop faculty to acquire and manipulate the components needed for construction. Multiple group meetings assured that we had enough hands helping with construction to assure timely construction as well as to help our members obtain the knowledge/skills associated with a project of this scale.

We are currently wrapping up the testing stage (making sure the flow hood passes a series of threshold tests) and preparing for the shipment of the hood over to the hospital it was built for in Vietnam.

EWH is also preparing to take part in this year’s national BMES conference taking place this in October. We will be discussing our flow hood and our future ambitions for the project. In addition to the above project, we have been putting a vast majority of our efforts into establishing new projects and partnerships. We are currently working with Urban Autism Solutions to possibly aid them in construction of a wash pack for their farm where adults with autism are hired to gain real world working experience. Additionally, we have partnered up with the Biomedical Engineering Society (BMES) in their tutoring program to assure our members are able to have the option of tutoring experience. Lastly, we are once again participating in Project C.U.R.E. which involves our members commuting to a warehouse housing medical supplies and aiding in the packaging and repair of the equipment.

Everything mentioned above summarizes our efforts this past spring /summer; currently we are working on making sure that each of our plans go smoothly and are managed properly. We are also putting together additional projects (such as the flow hood) for our members. And last but not least, we will also be searching for various volunteering opportunities for our members to give back to society. For more information please visit: https://ewhuic.wordpress.com/

Biomedical Engineering Society (BMES)

While the student chapter of the Biomedical Engineering Society (BMES) at UIC is primarily focused on student projects, they are also committed to student engagement and empowerment. In the Fall 2015 semester, BMES sent 10 students to the Biomedical Engineering Midwest Regional Conference in Akron, Ohio to attend workshop sessions on careers in bioengineering and to network with employers. BMES hosted a field trip for its members to the International Museum of Surgical Science located in Chicago. Members of BMES volunteered to monitor the health status of participants during the Chicago Marathon and hosted a number of guest speakers, including Dr. Laura Miller, a prosthetist at the Rehabilitation Institute of Chicago. Last year, the 3D Printed Prosthetics team capped the year by designing and building a prosthetic arm for Drew, a six year old boy in North Carolina. This year, they updated the designs to fit Drew as he grows while also increasing functionality.

In summer 2015, BMES acquired EEG hardware to start a Brain-Computer-Interface (BCI) team. The BCI team has spent the fall semester isolating brain waves, 3D printing their headset, and learning signal processing software. The team plans to have a neurally controlled prosthetic arm by the end of next semester.

Beginning of the Spring 2016 semester, BMES members partnered with Be the Match to add people to their registry of potential bone marrow donors. They were able to enroll over 35 people, which is the second most successful day the organization has had on UIC campus. With the help of the Engineering Career Center, BMES was proud to assist in hosting the very first Bioengineering Industry Day. This was an opportunity for students to meet and network with alumni and local employers and engage in a discussion about life after graduation. In their final event of the semester, a group of BMES members visited the Round Lake campus of Baxter for a tour of the facilities.

Active projects for the year: 1) The 3D printed prosthetics team has designed, manufactured, and delivered two different prosthetic arms. One prosthetic arm was built for a young boy in North Carolina, and the second prosthetic was built for a young girl in Vietnam.

2) The Brain-Computer Interface (BCI) group has developed multipole projects to harness the power of EEG brain waves in order to control external devices and perform various cognitive tasks.

3) The Tongue-Computer Interface (TCI) team has developed a device that allows for a computer mouse to be controlled via the tongue muscle. This group received a provisional patent for their design. The TCI project was also accepted for presentation during the Student Design Competition at the American Society for Artificial Internal Organs (ASAIO) 62nd Annual Conference in San Francisco, and at this point they are guaranteed to be placed amongst the top three finalists.

For more information please visit: http://uic-bmes.weebly.com/

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Consilience of Conscience – A Book Review of “Lab Girl” by Hope Jahren, published by Alfred A. Knopf, New York, 2016 As an academic, a research engineer and a committed tree hugger, I found much to like in the 2016 memoir, “Lab Girl” by Hope Jahren, currently a Geology and Geophysics professor at the University of Hawaii. The book intertwines three themes that span her life and career: a love of plants, a passion for hard work, and a commitment to her friend Bill, her first and only laboratory manager. The themes develop chronologically, beginning with Hope’s first experience as a toddler in her father’s community college physics laboratory. They mature as she tries to live up to her mother’s keen intellect and high expectations, and reach full flower as she finds a home in the geology and soil science research laboratories at the University of Minnesota and the University of California at Berkeley. It is at Berkeley where she meets Bill and they become engaged in a shared pursuit of new knowledge, academic excellence, and a whole lot of just plain fun. This sense of fun pervades the book. It is fun for Hope to ‘explain’ the intricacies of photosynthesis to undergraduates.

It is fun for Hope to ‘think like a tree’ in trying to develop research proposals that probe how trees must learn to cope with global warming and rising carbon dioxide levels. And it is fun for Bill and Hope to dig a six-foot deep hole that exposes the innermost secrets of soil.

The book is divided into three sections (Roots and Leaves, Wood and Knots, Flowers and Fruit) that are each a metaphor for stages in her life and career. Unlike her first love – a blue spruce that grew outside her bedroom window – she can move on when snow and gales blow, so she charts a course as an academic research scientist that forces her to reseed her mass spectrometry laboratory three times; first at Georgia Tech, second at Johns Hopkins and currently at the University of Hawaii. In each microclimate she absorbs nutrients (and an occasional toxin), basks in the sunshine of surprising discoveries, goes dormant enduring the cold shoulders of a few colleagues and more than a few granting agencies, but ultimately prevails. Along her life’s trajectory, Hope learns, as we all do, more about herself and more about how to symbiotically interact with her surroundings. Spoiler alert: This is a thoroughly honest memoir that speaks directly to the reader on an up-close-and-personal level.

Hope is too good of a scientist and too skilled as a writer to cut corners or prune unflattering branches from the edges of her story. Nevertheless, there is a tone of consilience, in the sense that biologist Edward O. Wilson used it (“a conviction, far deeper than a mere working proposition, that the world is orderly and can be explained by a small number of natural laws.”) that flows through her life and career. Thus, now successful and settled professionally, happily married with a young son, and with time to write about her journey, she can look back with a clear vision and conscience.

Looking back, she reflects on the love and devotion that her parents, her mentors, her husband, Clint, and her lab partner, Bill, have showered on her. She mentions near the end of the book that, “I used to pray to be made stronger; now I pray to be made grateful.” I certainly am grateful to her for sharing her book and her life. In closing, as a scientist, I feel obligated to quantify my opinion of this book. Since, unlike temperature, there is not an absolute scale of literature, I will place this book in the warm colors of the spectrum of nature writing that spans, in my experience, the writers Rachael Carson (“Silent Spring”) for her lyrical scientific style, Annie Dillard (“Pilgrim at Tinker Creek) for her poetic description of the natural world, Roger Deakin (“Wildwood: A Journal Through Trees”) for his immersive love of trees and soil, Aldo Leopold (“A Sand County Almanac”) for his commitment to conservation and environmental restoration, and Helen Macdonald (H is for Hawk) for her fierce honesty in confronting all living things. I enjoyed the book very much, and I hope that you will also make its acquaintance.

UIC Bioengineering Student Journal (UBSJ)

Written by co-editors Cierra Hall, Brynne Nicolsen and Christine Joseph The UBSJ was founded by former department head and University Distinguished Professor Richard Magin in Fall 2008 and has been published in six subsequent issues with the goal of providing students with more opportunities to practice all aspects of the technical writing, reviewing and editing process.

The journal has succeeded in bringing together students at different levels of education, from freshman undergraduates to the graduate members of the editorial board. Students submit articles that discuss original research or review research published elsewhere. This allows students to hone their writing skills without being limited by a lack of data. The journal also provides students with an opportunity to be involved as editors and reviewers, giving students an overall appreciation of the processes involved in disseminating scientific findings. Finally, the journal serves to expose the authors, reviewers and readers to current trends in the bioengineering field.

Completed research projects are not necessary for publication, nor does publication in the UBSJ preclude later publication of the results in a more complete presentation. Articles are intended to document research accomplishments to date, and it is expected that many of the articles that appear in the journal will later be expanded to full-length studies and published elsewhere. Submissions can range from original research articles and technical reviews to book reviews relevant to bioengineering. Students often publish papers which were written to fulfill a class assignment, and a few of the issues have focused primarily on a single course, such as Biomedical Imaging (BIOE 421) or Biological Systems Analysis (BioE 310). By using a previously written paper, students are able to further experience the process of reviewing and revising their written work, an opportunity which is not often presented within the context of a class.

After submitting an article, authors work closely with a number of students to improve their work through a number of review processes. Authors, reviewers and editors meet at biweekly meetings to review the progress of the articles and discuss any suggestions about which reviewers and authors disagree. After this process is completed, the editorial board performs the final review of the articles and composes the official document which is sent to the printing company. The editorial board also works together to locate and work with a graphic designer for the unique cover art of each issue. At the end of the year, the authors, reviewers and editors celebrate another successful issue at the publication party, where students and professors alike can discuss the articles over refreshments.

A number of professors also vote on the recipient of the Best Author award, which is presented at the party.

Through peer review, personal authorship and management of the publication by the board, students are able to hone a wide degree of the type of skills needed by professional engineers and scientists post-graduation. These include learning to incorporate constructive feedback during article review, learning to manage one’s time well, developing attention to detail during the review process and working well together in groups, among many others. We hope that the UBSJ continues to flourish in the years to come through the hard work and dedication of UIC bioengineering students.

Download the newest version at: http:// bioe.uic.edu/ubsj/

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Microfabricated Tissue Models Lab

- Salman Khetani, PhD

Our Mission The liver has many functions, such as breakdown of food, detoxification of drugs, and production of proteins that allow proper clotting after a wound. In liver failure, a person can die within hours unless a liver transplant becomes available; however, there is a severe shortage of donor organs. Additionally, liver injury caused by drugs is a major reason behind drug withdrawal from the market, which affects patients’ lives and the economy since it takes $13-15B and 12-15 years to develop a single drug. Testing drugs on animals or using animal livers for transplantation is not ideal because of evolutionary differences across species. Therefore, the Microfabricated Tissue Models (MTM) lab at UIC engineers human liver tissues that have utility in: screening toxic drugs in vitro (in a dish) before they reach humans, mimicking liver diseases for developing novel drugs, and cell-based therapies for patients suffering from liver disease. We utilize tools from engineering and biology, and collaborate with researchers from various disciplines to accomplish our goals. Our team is made up of bioengineers with backgrounds in engineering design, life sciences, biomaterials and microfabrication. We are grateful for funding support from the DOD, FDA, NIH and NSF.

Our Impact We use a micropatterned co-culture (MPCC) platform comprised of micropatterned islands of human liver cells (hepatocytes, Figure 1) surrounded by fibroblasts. Without fibroblasts, hepatocytes quickly die off, but they can survive for 4 weeks in MPCCs, which enables their use in different applications. The micropatterning of cells is accomplished using tools adapted from the semiconductor industry, allowing for a precision (Figure 2) not possible with conventional methods. MPCCs have shown great promise for studying global liver diseases. In particular, when exposed to excessive glucose as in diabetes, the hepatocytes within MPCCs become resistant to insulin’s effects on reducing liver glucose output, a hallmark of diabetes. Novel drugs can be discovered using this feature of MPCCs. Additionally, when cultured in MPCCs, hepatocytes derived from induced pluripotent stem cells (iPSCs) from patients can be infected with hepatitis C virus over several weeks, which allows investigations into why some patients respond to treatment while others do not. We continue to improve the physiological relevance of the MPCC system to make it more sensitive for applications. For instance, we have discovered ways to prolong MPCC longevity to 2+ months, which is useful for understanding how taking drugs over a longer time period can cause liver toxicity. Furthermore, we are designing a microfluidic system to allow perfusion of MPCCs with fresh nutrients and removal of waste products, towards mimicking the heart pumping blood through the liver in the body. Beyond MPCCs, we are exploring growing hepatocytes in vitro, building a 3D human liver tissue for implantation, and devising strategies to make iPSCs into more functional hepatocytes.

Our Students The MTM lab fosters creativity in research and design using state-of-the-art tools in engineering and biology. We teach collaboration, scientific communication, and a passion for making a difference. Below, our graduate students comment on why they chose the MTM lab and the impact they are making through research.

I joined the MTM lab to help solve real-world problems, and because Dr. Khetani’s advising style fits what I needed from a mentor. I have worked on several projects towards the goal of engineering complex liver models for screening drugs and studying infectious diseases. Currently, I am developing a model to enable the study of why and how hepatitis C viral (HCV) infection progresses variably in different patients, which has implications for personalized HCV treatment. Our lab also emphasizes collaboration, which has allowed me to draw on the expertise of both academic and industrial groups. The MTM lab has provided me with a deeper understanding of how to design and conduct experiments that will make an impact, and helped me develop the skills I need to be a successful professional. – Christine Lin I joined the MTM lab because Dr. Khetani and I have a similar passion for progressing medicine and health. The major advantage of working with Dr. Khetani is that he has given me the creative space to develop a new area of research in our lab around understanding diseases associated with obesity such as diabetes. My work has provided the diabetes field with a sensitive new

tool to help understand the detrimental insulin resistance that occurs in the liver, which brings me great pride as much of my family is impacted by this disease. The MTM lab has not only provided me with excellent training through many aspects of biomedical engineering, but it has also allowed me to find my passion by nurturing my interests. – Matthew Davidson My research at the MTM lab is focused on developing in vitro platforms for better understanding mechanisms of drug-induced liver toxicity using different cell sources such as primary hepatocytes, induced pluripotent stem cell-derived liver cells, mouse liver cells, and liver end-othelial cells. Currently, I am developing a microfluidic platform to perfuse liver cultures with nutrients and remove waste products. What attracted me to the MTM Lab was the interaction between engineering techniques and biological inquiries for meeting real healthcare needs. The training and mentoring I have received from Dr. Khetani will enable me to become a leader in research and science.

Most of the experiences I have in the lab, from planning experiments to advising undergraduates to presenting at conferences, are directly translatable to many future career trajectories. – Brenton Ware

Figure 1: A micropatterned colony of human liver cells surrounded by fibroblasts.

Figure2: Precise micropatterning of cells using tools from semiconductor manufacturing.

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In-Situ Nanomedicine Tolou Shokuhfar’s In-Situ Nanomedicine Laboratory (ISNL) in the Richard and Loan Hill Department of Bioengineering consists of 25 members, including 3 postdoctoral fellows, 6 PhD students, 10 master’s students and 6 undergraduate students. ISNL houses three main research domains: 1) in-situ electron microscopy of biomolecules and biomaterials to investigate the dynamics of biochemical activities in wet/hydrated environments for diagnosis and treatment of human diseases; 2) development of smart multifunctional nanobiomaterials with applications in biomedical implants including dental and orthopaedic, and cardiovascular devices, total mandibular joints and islet transplantations; and 3) 3D bioprinting technology which utilizes customized bioink infiltrated with viable cells in the printed construct to regenerate tissues or organs.

Understanding the dynamics of hydrated biomolecules and living cells without compromising their functionality at nanoscale resolution remains challenging. With the development of a novel biocompatible Graphene Liquid Cell (GLC) technique by the experts in our group, we are now not only able to obtain ultra high resolution images of biomolecules and living cells, but also to understand the structure and chemistry of proteins, bacteria, cells, fluids-polymer interactions, biomineralization of ferritins, hydroxyapatite, kidney stones and antibacterial nonwoven polymers. In collaboration with Dr. Jose Oberholzer, Chief of Transplantation Surgery and Director of the Islet and Pancreas Transplant Program at the University of Illinois Hospital & Health Sciences System and his team at The Chicago Diabetes Project, we are investigating the sub-cellular activities in islet cells with the aim to overcome diabetes. In addition, with support from the National Science Foundation and Argonne National Laboratory we are investigating the biomineralization of healthy and dysfunctional ferritins. In collaboration with Pacific Northwest National Laboratory we have also developed a novel in-situ liquid TEM platform that enables live cell imaging and and spectroscopy with unprecedented high resolution.

Furthermore, we investigate the mechanism of bacterial adhesion inhibition through nanotextured antibacterial non-wovens.

Revision surgeries or post-surgical complications in patients with biomedical implants are recurring problems resulting in costly and risky surgeries/treatments. We have developed a smart multifunctional nano biomaterial that has potential to fight infection, improve cellular interaction with implants, act as a drug delivery system, and mimic the compact bone structure. In collaboration with UNESP, INMETRO in Brazil, Northwestern University, Rehabilitation Institute of Chicago, Rush Medical Center, and Texas Heart Institute we are developing 1) Thermo sensitive scaffolds that can prevent heterotopic ossification at maxillofacial joint implants, 2) nanotextured surface for infection-free cardiovascular devices and 3) smart drug eluting nanomaterial that can provide localized treatment for prevention of post implant complications in limb prosthesis. Most of our work has attracted great media and news attention including CNN, phys.org, ABC News, Dental News Network and Science Daily.

We have been funded by the National Science Foundation NSF DMR CAREER award (#1564950), The American Academy of Implant Dentistry,

Dr.Shokufar advising students of ISNL lab on Surface Modification of a Hip Implant with multifunctional antimicrobial TiO2 nanotubes

Laboratory

-Tolou Shokuhfar, PhD

The Nonwoven Institute, Pacific Northwest National Lab, Argonne National Lab, the Chicago Biomedical Consortium, and have received recognition including 2016 TMS FMD Young Leaders Award from The Materials Society (TMS), the DSL Young Scientist Award, the INSIGHT Diversity 2015 National Award for Inspiring Women in STEM, the 2016 M&M student award, the IAB 2016 Technical Merit award. We have published 62 peer reviewed journal articles including Advance Materials, Nature Reports, and ACS Nano, 82 conference proceedings, and presented 26 invited talks.

My research at the ISNL is mostly focused on 3D bioprinting of living tissues, specifically neural tissue. In this process I’m trying to develop my own bioink with specific properties for different tissues. I started working with Dr. Shokuhfar after knowing that she’s open to working on new ideas no matter how futuristic and out of reach these ideas look like. She, in her academic career already proved that if there is a will, there is a way. I enjoy working at ISNL, because there is a lot of freedom to be creative and work on your own ideas, and have a great support even if the goal is too far to reach. When it seems impossible it can be really easy to get into a defeatist mentality and that just adds to the impossibility of it all. But, Dr. Shokufar taught me a good lesson in my research and life, if you never fail, you will never grow.

-Shayan Shafiee I joined the In Situ Nanomedicine Laboratory (ISNL) in the beginning of 2016 from Ames Laboratory. My motivation to join the lab was twofold: 1) Dr. Shokuhfar is a leading scientist in developing and using advanced electron microscopy imaging techniques for hydrated/soft biomaterials, 2) under her supervision, the ISNL Lab members have been developing nanomedicine treatments. Along with Surya Narayanan and other members of the lab, I am working on finding nano-cures/medicines for various illnesses ranging from anemia, Alzheimer’s, kidney stones to diabetes. I have been learning a lot from her in terms of professional writing, ciritical thinking and developing research ideas as a result of which I was sucessful in obtaining a CBC Post-doctoral grant just within four months from joining her lab. All this in the long run will help me transition into my next position hopefully as a faculty member.

-Emre Firlar, PhD I joined Dr. Tolou Shokuhfar’s ISNL due to our shared interests in biomaterials and bioimaging, and her deep investment in students. My current research focuses on treating kidney stones as well as antifouling nonwoven materials. In these projects I use in situ imaging techniques including Graphene Liquid Cells and liquid flow imaging. Under her guidance I’ve learned a broad range of bioimaging skills including Transmission Electron Microscopy, Scanning Electron Microscopy, chemical and material structure analysis methodologies. Developing these skills required a significant amount of both time and money on ISNL’s behalf, and will carry over into my future career. One of Dr. Shokuhfar’s unique skills is bringing together an effective team and setting an environment that is constructive for research and building professional networks and collaborations. In my first few semesters under Dr. Shokuhfar’s mentorship I’ve already developed significantly as a researcher and as a bioengineer, and I look forward to continuing to do so during my remaining time as a student in ISNL. -David J. Banner

3D Bioprinting of living scaffolds for tissue regeneration

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Cell Mechanics and Signaling Laboratory “Alzheimer’s is a very complex disease,” observed Dr. James Lee, a bioengineering associate professor at the University of Illinois at Chicago. According to Alzheimer’s Association, more than 5 million Americans are living with Alzheimer’s. By 2050, these numbers will escalate rapidly, tripling from 5.2 million to a projected 13.8 million, if there is no medical breakthrough to prevent or cure the disease. Lee’s research focuses on the roles of molecular, membrane, cellular, and tissue mechanics in the pathology of Alzheimer’s disease.

After receiving undergraduate and graduate engineering training at University of California, Berkeley and University of Pennsylvania, respectively, Lee determined to apply his previous engineering training to studying mechanisms of Alzheimer’s Disease with a hope to discover new therapeutic strategies for the treatment of the disease. Specifically, Lee employs biophysical engineering techniques, such as atomic force microscopy, to observe cellular and membrane mechanics, molecularly-specific cell adhesion, and activities at the picoNewton and nanometer levels; fluorescence microscopy of LAURDAN to characterize local membrane molecular order; molecular rotor to characterize membrane fluidity to unveil the mechanisms underlying the cell signaling and pathways involved in Alzheimer’s disease, including oxidative stress, neuroinflammation, mitochondrial dysfunction, neurovascular dysfunction, amyloid precursorprocessing that produces neurotoxic amyloid-β peptide (Aβ), and Aβ clearance in the brain.

Over the past 10 years, Lee’s research group has been supported by the National Institute of Neurological Disorders and Stroke, National Institute of Aging, Alzheimer Association, Missouri Spinal Cord Injury Research Program, and Ministry of Education in the Republic of Kazakhstan.

Tao Teng performing an experiment using atomic force microscopy (AFM) to measure cell mechanical properties.

for Neurodegenerative Diseases

- James Lee, PhD

In addition to the focus of Alzheimer’s research, another emphasis of Lee’s research group is its education and research mission to provide an excellent and friendly research environment and opportunity for students from diverse backgrounds at different education levels. At the University of Missouri, Lee was an active mentor for McNair scholars. McNair scholars are either first-generation college students with financial need, or members of a group that is traditionally underrepresented in graduate education and have demonstrated strong academic potential. As research careers can be developed starting from an early stage of education, high school students are always welcome and encouraged to gain hands-on experience in the Lee research group during summer break.

Starting as an undergraduate student, I have been doing research in Dr. James Lee’s lab for about 5 years and finished my master thesis under Dr. Lee’s supervision. Currently, I am a PhD student in his lab leading a project to investigate the responses of astrocytes to different mechanical environments, as Alzheimer’s brain tissue has been reported to be softer as the disease progresses. We employed atomic force microscopy for measuring the mechanical changes in astrocytes, such as membrane stiffness and membrane tethering force in relation with cell functions. For the cell signaling aspect, I use the western blot method for protein quantification and various fluorescence microscopy techniques for characterizations of structural organizations at the sub-cellular level. When I joined the lab as an undergraduate student, I knew nothing about cell culture. With the years in Dr. Lee’s lab, I learned a lot of techniques for cell biology study. But, the most important thing I learned is the way to think as an independent researcher. – Tao Teng As a bioengineering graduate student in Dr. James C. Lee’s Lab, I apply my engineering expertise to study the pathology of Alzheimer’s disease which entails both the nervous system and the immune system - two of the most interesting fields, at least in my opinion. My current project involves studying the chemical and mechanical responses of endothelial cells to amyloid beta, a peptide abundant in Alzheimer’s brains. Advanced equipment is required for modern analysis techniques, and my lab has provided me the resources and training for me to utilize atomic force microscopy, immunofluorescence microscopy, and western blot. Dr. Lee has welcomed me into his international network of colleagues who have provided additional advice on my experimental design, technique and project direction. In addition to innovative research projects, I have received training and practice in writing grants and giving presentations which are essential skills for a successful career.

– Stephanie Tolbert

A cell sample mounted on the AFM stage.

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Seminar Series (2015-2016)

FALL 2015

Dynamic Functional Chemical Imaging in the Chest-painting the tissue with light Jaishankar Raman, MD, FRACS, PhD Rush University Medical Center

Engineering stable liver models for applications in drug screening and disease modeling Salman Khetani, PhD Associate Professor, Department of Bioengineering University of Illinois at Chicago Inertial microfluidics for label-free separation and isolation of cells Ian Papautsky, PhD Professor of Electrical Engineering, Director, BioMicroSystems Lab Director, The Ohio Center for Microfluidic Innovation (OCMI) Department of Electronics and Computing Systems The brain as a dynamical system: An engineering perspective on neuroscience Gabriel A.Silva, PhD Department of Bioengineering, Department of Ophthalmology, Neurosciences Program University of California, San Diego Modeling motor neuron diseases with human pluripotent stem cells Xue-Jun (June) Li, PhD Assistant Professor Department of Neuroscience University of Connecticut Health Center New approaches for treatments of skeletal diseases Anja Nohe, PhD Associate Professor Director of the Laboratory of Cellular Signaling and Dynamics Department of Biological Sciences University of Delaware Bacterial Outer Membranes and Interactions with Membrane Proteins Wonpil Im, PhD Professor, Center for Computational Biology and Department of Molecular Biosciences University of Kansas An Experimental and Computational Approach to Characterize Corneal Biomechanical Properties Hamed Hatami-Marbini Professor, Department of Mechanical & Industrial Engineering University of Illinois at Chicago Engineering Advanced Biomaterials: From contrast agents for brain tumor imaging to super biocompatible hydrogels for pancreatic islet cell immunoisolation Omid Veiseh, PhD Congressionally Directed Medical Research Program Fellow Department of Chemical Engineering and The David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology (MIT) A Novel Biosensor Engineered from Outer Membrane Protein G Min Chen, PhD Department of Chemistry University of Massachusetts Amherst A Normative View of Motor Control and Learning Max Berniker, PhD Department of Mechanical and Industrial Engineering Cerenkov Imaging – faster than the speed of light Jan Grimm, MD, PhD Memorial Sloan Kettering Cancer Center Big Data Sciences for Personalized and Precision Medicine Xiaobo Zhou, PhD Professor of Diagnostic Radiology Director, Center for Bioinformatics & Systems Biology Wake Forest University - School of Medicine

Stroke in Petridish: Chocolates and Wine Megha Agrawal, PhD Department of Biology University of Arkansas at Little Rock

SPRING 2016

Neurorehabilitation of the hand following stroke Derek Kamper, PhD Associate Professor, Department of Biomedical Engineering Illinois Institute of Technology Harnessing mechanobiology to engineer novel therapeutic approaches for hematological and immune diseases Jae-Won Shin, PhD Assistant Professor,Department of Pharmacology (Primary) Department of Bioengineering (Affiliate) University of Illinois at Chicago The future of MRI: More power for research and more utility for diagnostics J. Thomas Vaughan, Jr., PhD Professor, Biomedical Engineering & Electrical Engineering Center for Magnetic Resonance ResearchUniversity of Minnesota Ions at the Nanoscale:The role of Ion-Ion correlations in biology and engineered devices Dirk Gillespie, PhD Department of Molecular Biophysics & Physiology, Rush University Medical Center Neural Injury: Strategies for detection & regeneration Sarah E. Stabenfeldt, PhD Assistant Professor School of Biological and Health Systems Engineering Arizona State University Bringing Molecular Diagnostics out of the lab to the point of care Jacqueline C. Linnes, PhD Assistant Professor Weldon School of Biomedical Engineering Purdue University Label-free Optical Micro Imaging of Tissue Histology in vivo Xingde Li, PhD Professor of Department of Biomedical Engineering Johns Hopkins University Engineering gene networks to program bacteria and their communities Ting Lu, PhD Assistant Professor, Department of Bioengineering University of Illinois at Urbana Champaign Hydrophobicity versus dipole interactions in self-assembly processes Silvina Matysiak, PhD Assistant Professor, Fischell Department of Bioengineering University of Maryland Learning why we fall and why we don’t… one step at a time Andrew Sawers, PhD Assistant Professor, Department of Kinesiology and Nutrition University of Illinois at Chicago Haptics and Virtual Reality in Surgical Simulation and Training Cristian Luciano, PhD Research Assistant Professor University of Illinois at Chicago

Bioengineering Experience for Science Teachers (BEST) The College of Engineering and College of Education are excited to offer a summer research program for CPS high school teachers starting Summer 2016. The summer research experience will provide an opportunity for pre-engineering and science teachers to spend time in bioengineering research labs and use the experience to create a curriculum for use in their own classrooms. The sixweek program matches teachers to a laboratory under the guidance of one of thirteen research-active core bioengineering faculty mentors. These lab opportunities are in diverse areas that include 3d printing laboratory equipment, tissue engineering, biomedical imaging, brain activity monitoring, computer simulation of proteins, rehabilitation engineering, bioacoustics, biomaterials, and mechanics of the pulmonary system. In partnership with faculty who are recognized experts in curriculum design and teaching in secondary education, and in particular, teaching of secondary science in urban schools, participant-tailored curricular mentoring in weekly workshops will focus on principles of effective planning, instruction, and assessment to be directly connected to teachers’ classroom curriculum.

The BEST Program is supported by the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health under award number R25EB021733­01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Program highlights > $8,000 stipend for all participants > $1000 classroom supplies allowance Who may apply >CPS high school science or engineering teachers >Underrepresented minorities and applicants committed to working with diverse student populations are encouraged to apply.

Program requirements > Teacher Fellows must commit to participating for the full 6 week program. > Teacher Fellows will participate in lab research experiences and curriculum workshops. > Teacher Fellows will participate in program evaluation.

For more information visit: https://bestbioe.uic.edu/

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Guaranteed Paid Internship Program The University of Illinois at Chicago College of Engineering is the first in the country to guarantee all incoming freshmen placement in a paid internship the summer following their first year: provided they meet the required criteria. The goal of the program is to expose students to real-life work experience in conjunction with their education and eventually making the post-graduation transition easier. Job placement rates after graduating increase dramatically with each internship.

2016 GPIP Participants: Kholoud Baste Sunil Dommaraju Jessica Espejo Celine Macaraniag Rene Mariona Mary Ann Metzger Rebecca Mitra Lara Nammari Taiwo Osinloye Equally important is the development of strategic corporate Julian Pacheco partnerships. To this effect, the Guaranteed Internship Pro- Success Story gram connects UIC’s engineering students with companies Florian finished his freshman year and organizations. Incoming engineering freshmen have the in May 2014 and was one of the highest average ACT scores in the University. As part of the first cohort of students in the Guarprogram, each incoming engineering freshman class is guar- anteed Paid Internship Program. anteed a paid internship the summer following their first He was hired by Knowles Elecyear at a collaborating company or current UIC research lab. tronics and did a good job for them The UIC College of Engineering currently has more than 150 projects funded by $66 million in grants. Each internship lasts for at least eight weeks and for students placed in outside companies and organizations, the expected pay is between $15 to $25 per hour. For students placed within UIC research labs, the expected pay is $10 per hour. Since 2012, over 300 companies and organizations have hired UIC engineering students and alumni as interns and full-time employees. For students that are interested in the program, please visit http://ecc.engr.uic.edu/guaranteed-paid-internship-program/. For companies that would like more information on how to post internships, please email engrjobs@uic.edu or call 312-996-2311.

Hita Patel Krunal Patel Meghna Peesapati Yassmin Saqri Angelica Smith Harini Sriram Tina Trinh Jude Vazhappily Katherine Xie Colin Xu

and really enjoyed it. Afterwards, he created a LinkedIn account. It just so happened that Apple, Inc. recruiters were scanning connections, looking for interns, saw his connection to Knowles, contacted him, interviewed him, and has offered him a full-time co-op to start working in Cupertino, CA in January 2015 to work through summer.

Companies which participated in GPIP “Having the hands-on experience to learn how to use Matlab and Comsol for real applications was the most satisfying part of my summer. It was my first time programming, and now I have a better understanding of the importance of running experiments while considering all outside factors.”

-Sara Mohamed (BS ’17) Bioengineering Internship: UIC Acoustics and Vibrations Laboratory

Clinical Immersion Internship The Richard and Loan Hill Department of Bioengineering offers a once in a lifetime internship opportunity to our undergraduate students. The Clinical Immersion Program is a six-week internship designed to provide intensive exposure to the clinical environment in order to conduct human-centered research focusing on observation and needs assessments. Small groups of students rotate every three weeks through two hospital clinics. Each team is provided a clinical mentor in each rotation.

This program, in preparation for the Interdisciplinary Medical Product Development class, allows students to identify real needs as they shadow medical personnel in a UIC clinical environment. Through collaborations with doctors at the UIC hospital, students will witness medical procedures, investigate the philosophy of approach by the practitioners, participate in problem-solving sessions, and identify problems or difficulties that can potentially serve as a future opportunity for improvement through bioengineering design.

The success of the program lies in exposing students to the entire medical product development cycle, beginning in the earliest stages of needs assessment. This new program is another commitment by the Department of Bioengineering to help students gain experience outside the typical classroom.

Learn more and read about actual experiences from the interns’ blogs at: https://clinicalimmersion.uic.edu/

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SENIOR DESIGN EXPO All undergraduate Bioengineering students must take the two-semester Senior Design sequence ( BIOE 396/397) toward the end of their curriculum. This course is intended to give students experience managing a project from start to finish, and applying their course knowledge to real-life design challenges. Specific course objectives include: system or component design, applying standard engineering practices, project management skills, teamwork, and both written and oral communication skills.

Every April, students present their project at EXPO, the annual College of Engineering Senior Design Competition. Historically, Bioengineering design teams are among the strongest in the College of Engineering and are well represented among the EXPO winners.

Bioengineering Winners at the 27th Annual Engineering Expo: Assisted Living Devices Reducing Heat Buildup through the Application of a Water-Based Cooling Pad on Contoured Wheelchairs Mario Castillo, Mark Lopez, Vivian Pedroza, Jaskaran Rajput Medical Devices II Resection Tool to Limit Perforation of Bladder Wall Nathan Albaugh, Ossama Anis, Ramon Espino, Gary Ling, Jeff Marsh Medical Products Novel Keratoprosthesis for Corneal Blindness Lavanya Nese, Marianne Palczewski, Tiana Wong

BIOENGINEERING INDUSTRY DAY Bioengineering Industry Day was created to help our students learn more about the types of industry opportunities available to them for internships and their future careers. It also gave them a chance to network with bioengineering professionals working in the field.

The inaugural event was attended by 15 professionals from 10 different companies: Ryan Orda, Engineer I [Abbott ] Mary Kuriakose, Study Management Associate [AbbVie] Justin Thomas, Engineer I [Baxter] Shawn Oppegard, Principal Engineer [Baxter] Subhi Saadeh - Engineer II [Baxter]

Jasen Massey, Medical Device R&D Engineer [Endotronix Inc.] Jesse Vazquez, Center for Nanoscale Materials [FDA Chicago] Greg Czaplewski, New Prodcut Development Engineer [Hollister Incorporated][ Paul C. Fletter, Innovation Manager [Hollister Incorporated] John Collins, Managing Director, Development [iBIO] Mahmoud Alsharbini, Quality Engineer [Midmark Corporation] Mohammed Farooqui, New Product Development Engineer [Pfizer (Hospira)] Catherine Kang, Sr. Associate, Global Regulatory Affairs [Pfizer (Hospira)] Tiffany Coleman, Business Development Manager [Sequence QCS] There were 86 students who attended, both from the undergraduate and graduate level. We anticipate holding this or a similar event each semester. We welcome new company representatives in the future. If you would like to participate, please contact Tom Cicero (tcicero@ uic.edu), Assistant Director of the Engineering Career Center.

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FACULTY NEWS

STUDENT NEWS

Dr. Alex Leow, Associate Professor of Psychiatry and Bioengineering at UIC, was quoted in an article in The Daily Dot on the use of smartphone apps to help track mood disorders. Leow was team leader for BiAffect, a study that uses a smartphone’s keyboard to track and predict mood episodes in bipolar disorder.

Vishal Varma was the recipient of 2015 FACSS Student Poster Award for his presentation on New Routes for Tissue Pathology using Quantum Cascade Laser Based Imaging Microscopes.

Dr. Michael Stroscio, Professor of Bioengineering and Electrical & Computer Engineering has received UIC Award for Excellence in Teaching (AET) for the 2015-16 academic year.

Alessandro Scotti was the recipient of CCTS Multidisciplinary Team Science award for his College of Medicine Research Forum project, “B0-calibrated and motion-registered dynamic CEST-MRI during calf muscle exercise.”

His project was co-authored by Drs. Rong-Wen Tain, Kejia Cai and Xiaohong Joe Zhou.

Dr. Miiri Kotche was the recipient of the 2016 Associate for Women in Science (AWIS) Chicago Area Chapter “Motivator of the Year” Award.

Dr. Jose Oberholzer’s research on effect of Encapsulated Human Islet cells on blood sugar levels in mice was published in Nature Magazine.

Dr. Jie Liang and Dr. Bhaskar DasGupta authored a graduate level textbook titled Models and Algorithms for Biomolecules and Molecular Networks.

Dr. Tolou Shokuhfar was the recipient of TMS Young Leader Award.

Dr. James Patton and Justin Horowitz were cited in an article in the online edition of the Smithsonian Magazine about their research on Psychic Robot.

Dr. Urmila Diwekar was the recipient of the 2015 Energy and Sustainability Award from AIChE.

ASTM Standard “Preclinical Assessment of Engineered Cartilage Tissue Growth Using MRI” developed by Mrignayani Kotecha New proposed ASTM standard (WK 55272) “Standard Test Method for Tissue Engineering Medical Products – Preclinical Assessment of Engineered Cartilage Tissue Growth using MRI” is based on techniques developed here at the Bioengineering department at UIC. It is intended as a standard test method for the assessment of engineered cartilage tissue growth during the early stages of tissue growth. This standard describes how T2 MRI can be used for quantification tissue growth in engineered cartilage in vitro and in vivo and how to remove the interference from scaffold in the tissue growth assessment using MRI. Currently, most engineered cartilage tissues are assessed using immunohistochemical techniques that are destructive. MRI is noninvasive and provides very high resolution images (~20 μm -100 μm) of samples in the case of in vitro and small animals.

This standard is designed to promote the use of preclinical MRI assessment in cartilage regenerative therapies. The MRI assessment of tissue engineered cartilage at preclinical stage will provide a reference MR data when these techniques move to higher animals and eventually to clinics. We expect that this standard will be widely used by scientists and engineers working on cartilage regenerative therapies in academia and in industry.

ASTM is promoting this standard in its Sept/Oct newsletter.

The link to the news can be found at : http://www.astm.org/standardization-news/?q=update/ knee-cartilage-repair

Ahmed Metwally won the Fall 2015 Chancellor’s Graduate Research award. He has also won the Graduate Research Award at the 2016 Student Research Forum. He was also a recipient of travel award to the Phylogenomics Symposium.

Maziyar M Khansari won the Student Presenter Award and the GSC Travel Award from the Graduate College.

Minhaj Nur Alam won a Fellowship of $6,000 from the Ministry of Information and Communication Technolgy, Bangladesh. This fellowship supports outstaning students to pursue their research work outside the nation.

Jesse Gerringer won the UIC Honors College Undergraduate Research Fellowship Grant for Fall 2015.

Samuel Dreyer has won the Spring 2016 Chancellor’s Student Service and Leadership Award and “Fifty for the future” by the Illinois Technology Foundation.

Vidyani Suryadevara won the 2016 Midwestern region Scholar from American Federation for Medical Research for her work on “Role of Phospholipase D in Idiopathic Pulmonary Fibrosis”. She has also won the 2016 Trainee Travel Award for the CSCTR/MWAFMR Combined Annual Meeting. She was also awarded the Chancellor’s Student Service Award 2016.

Naomi Faulk won the UIC Honors College Undergraduate Research Fellowship Grant for Spring 2016.

Recipients of Pre-doctoral Education for Clinical and Translational Scientists Scholarship: Anthony Felder Cierra Hall Brian Henry Michael Mkrtschjan Maziyar Mohammadtalab Khansari

ARCHIVAL JOURNAL PUBLICATIONS OF CORE FACULTY AND THEIR STUDENTS Azimi Nasim, Zheng Xue , Libo Hu , Christos Takoudis, Shengshui Zhang , and Zhengcheng Zhang,“Additive Effect on the Electrochemical Performance of Lithium-Sulfur Battery” Electrochimica Acta 154, 205-210 (2015) Azimi Nasim, Zheng Xue, Nancy Dietz Rago, Christos Takoudis , Mikhail L. Gordin, Jiangxuan Song, Donghai Wang, Zhengcheng Zhang, “Fluorinated Electrolytes for Li-S Battery: Suppressing the Self-discharge with an Electrolyte Containing Fluoroether Solvent” Journal of The Electrochemical Society 162, A64-A68 (2015) Azimi Nasim; Xue, Zheng; Bloom, Ira; Gordin, Mikhail; Wang, Donghai; Daniel, Tad; Takoudis, Christos; Zhang, Zhengcheng, “Understanding the Effect of Fluorinated Ether on the Improved Performance of Lithium-Sulfur Batteries,” ACS Applied Materials & Interfaces 7, 9169-9177 (2015) Bishal Arghya K, Arman Butt, Sathees K. Selvaraj, Bela Joshi, Sweetu B. Patel, Su Huang, Bin Yang, Tolou Shukohfar, Cortino Sukotjo, Christos G. Takoudis, “Atomic Layer Deposition in Bio-Nanotechnology: A brief overview,” Critical Reviews in Biomedical Engineering 43, 255-277 (2015) Brennan M.D., Rexius-Hall M.L., Eddington, D.T. (2015) “A 3D-Printed Oxygen Control Insert for a 24-Well Plate”, PLoSONE, 10(9): e0137631. doi:10.1371/journal.pone.037631 C Wang, T Shokuhfar, RF Klie, (2015), Using Graphene Liquid Cells for High-resolution Chemical Analysis of Nano-particle Reactions, Microscopy and Microanalysis 21 (S3), 1289-1290 C Wang, T Shokuhfar, RF Klie, Precision In Situ Control of Local Liquid Chemistry via Electron Irradiation,(2015), Microscopy and Microanalysis, 21 (S3), 265-266 Camp S.M., E. Ceco, C.L. Evenoski, S.M. Danilov, T. Zhou, E.T. Chiang, L. Moreno-Vinasco, B. Mapes, J. Zhao, G. Gursoy, M.E. Brown, D.M. Adyshev, S.S. Siddiqui, H. Quijada, S. Sammani, E. Letsiou, L. Saadat, M. Yousef, T. Wang, J. Liang, and J.G. Garcia. Unique Toll-like receptor 4 activation by NAMPT/PBEF Induces NFkB signaling and inflammatory lung injury. Scientific Report, 2015. doi: 10.1038/srep13135 Cao Youfang, Anna Terebus, and Jie Liang. Accurate Chemical Master Equation solution using multi-finite buffers SIAM Multiscale Modeling and Simulation , 2016. 14(2), 923–963. DOI:10.1137/15M1034180 Cao Youfang, Anna Terebus, and Jie Liang. State space truncation with quantified errors for accurate solutions to discrete Chemical Master Equation. Bulletin of Mathematical Biology , 2016. 78(4):617-661. PMCID: PMC4896403, DOI: 10.1007/s11538-016-0149-1 Carson M , J Gu, G Yu, H Lu, Identification of cancer-related genes and motifs in the human gene regulatory network IET Systems Biology 9(4):128-34, August 2015 Chang Siliang, Sathees Kannan Selvaraj, Yoon-Young Choi, Seungbum Hong, Serge M. Nakhmanson, Christos G. Takoudis, “Atomic layer deposition of environmentally benign SnTiOx as a potential ferroelectric material,” Journal of Vacuum Science & Technology, A 34, 01A119/1-5 (2016) Cui Xiaodan, Alan D. Zdunek, Gregory Jursich, and Christos G. Takoudis, “Nanostructured Ni-YSZ by Atomic Layer Deposition,” ECS Journal of Solid State Science and Technology, 4 (12) P429-P435 (2015) Dai Z, Peng Y, Mansy HA, Sandler RH, Royston TJ (2015). A Model of Lung Parenchyma Stress Relaxation Using Fractional Viscoelasticity. Med. Engin. Phys. 37(8), 752–758. http://dx.doi.org/10.1016/j.medengphy.2015.05.003 Davidson, M.D., Ballinger, K.R., and Khetani, S.R. (2016). Long-term Exposure to Abnormal Glucose Levels Alters Drug Metabolism Pathways and Insulin Sensitivity in Primary Human Hepatocytes. Scientific Reports, 6, article #28178 (online journal only) Emmadi, R., Canestrari, E., Arbieva, Z. H., Mu, W., Dai, Y., Frasor, J., & Wiley, E (2015). Correlative Analysis of miRNA Expression and Oncotype Dx Recurrence Score in Estrogen Receptor Positive Breast Carcinomas.” PLOS One, 10 (12): e0145346. DOI:10.1371/journal.pone.0145346. PMC4696739 Farid Sidra, Souvik Mukherjee, Hye-Son Jung, Michael Stroscio, and Mitra Dutta, Analysis on the structural, vibrational and defect states of chlorine treated polycrystalline cadmium telluride structures grown by e-beam evaporation, Mater. Res. Express 2 (2015) 025007 Farid Sidra, Xenia Meshik, Min Choi, Souvik Mukherjee, YiLan, Devanshi Parikh, Shripriya Poduri, Undarmaa Baterdene, Ching-En Huang, Yung Yu Wang, Peter Burke, Mitra Dutta, Michael A.Stroscio, Detection of Interferon gamma using graphene- and aptamer-based FET-like electrochemical biosensor, Biosensors and Bioelectronics, 71, 294-299 (2015). (High Impact Factor, ca. 6.6) Gould, I., Linninger, A. (2015) “Hematocrit Distribution and Tissue Oxygenation in Large Microcirculatory Networks”, Microcirculation, 22, p1-18 Grotberg J, A Hamlekhan, A Butt, S Patel, D Royhman, T Shokuhfar, Cortino Sukotjo, Christos Takoudis, Mathew T Mathew, (2016), Thermally oxidized titania nanotubes enhance the corrosion resistance of Ti6Al4V, Materials Science and Engineering: C 59, 677-689 Hamlekhan A, S.S. Ray, C.Takoudis, M.T. Mathew, C. Sukotjo, A.L. Yarin, T. Shokuhfar, (2015), Fabrication of Drug Eluting Implants: Study of Drug Release Mechanism from Titanium Dioxide Nanotubes, J. Phys. D: Appl. Phys., 48, 275401 doi:10.1088/0022-3727/48/27/275401 He K , Y Yuan, YP Lu, T Shokuhfar, R Shahbazian-Yassar, (2015), Dynamic studies of solution-based reactions using operando TEM, Microscopy and Microanalysis 21 (S3), 263-264 Horowitz JR, Madhavan T, Massie C, Patton JL (2016) “Reaching is Better When You Get What You Want: Realtime Feedback of Intended Reaching Trajectory Despite an Unstable Environment” Frontiers in Behavioral Neuroscience, fnbeh-09-00365 Horowitz JR, Patton JL (2015) I meant to do that: determining the intentions of action in the face of disturbances. PLoS ONE 10(9): e0137289 Hsu CY, Schneller B, Alaraj A, Flannery M, Zhou XJ, Linninger A, (2016) “Automatic recognition of subject-specific cerebrovascular trees”, Magnetic Resonance in Medicine Hsu Y, Tran M, Linninger A, (2015) “Dynamic regulation of aquaporin-4 water channels in neurological disorders.”, Croat Med J, 56(5): 401–421 Hu, H. Xu, JT. Xu and Y. Dai, Y. (2015), Regulatory Elements in Low-Methylated Regions Predict Directional Change of Gene Expression, IEEE Journal of Biomedical and Health Informatics,doi:10.1109/JBHI.2015.2431640. PMID: 25974955 Huang FE, Patton JL (2016) ”Movement distributions of stroke survivors exhibit distinct patterns that evolve with training,”” Journal of Neural Engineering and Rehabilitation, 13(23) (13 pages). DOI: 10.1186/s12984-016-0132-y” Im W, Liang J, Olson A, Zhou HX, Vajda S, Vakser IA. Challenges in structural approaches to cell modeling. J Mol Biol , 2016. DOI:10.1016/j.jmb.2016.05.024 PMID:27255863 Ismael Amber, Wei Tian, Nicholas Waszczak, Xin Wang, Youfang Cao, Dmitry Suchkov, Eli Bar, Metodi V. Metodiev, Jie Liang, Robert A. Arkowitz, and David E. Stone Gb promotes pheromone receptor polarization and yeast chemotropism by inhibiting receptor phosphorylation Science Signaling , 2016. 9(423):ra38, DOI: 10.1126/scisignal. aad4376

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Ivanov, A., Linninger, A., Hsu, C-Y., Amin-Hanjani, S., Aletich, V.A., Charbel, F.T., and Alaraj, A. (2015) “Correlation between angiographic transit times and neurological status on admission in patients with aneurysmal subarachnoid hemorrhage”, Journal of Neurosurgery, p1-7 Johnson T, Nandakumar N, Kenyon R, Patton JL (2016) “Sensory Recalibration from Visually Amplified Rotations while Walking,” CRC Critical Reviews in Biomedical Engineering, 43(4) 245-253. DOI: 10.1615/CritRevBiomedEng.2016016520 K Tangen, Hsu, Y., Zhu, D., Linninger, A. (2015) “CNS wide simulation of flow resistance and drug transport due to spinal microanatomy”, Journal of Biomechanics, 48, p2144-2154 Kearney SP, Khan AA, Dai Z, Royston TJ (2015). Dynamic viscoelastic models of human skin using optical elastography. Phys. Med. Biol. 60, 6975-6990 Kolli MB , NDPK Manne, R Para, SK Nalabotu, G Nandyala, T Shokuhfar, Kun He, Azhang Hamlekhan, Jane Y Ma, Paulette S Wehner, Lucy Dornon, Ravikumar Arvapalli, Kevin M Rice, Eric R Blough, (2015), Cerium oxide nanoparticles attenuate monocrotaline induced right ventricular hypertrophy following pulmonary arterial hypertension, Biomaterials 35 (37), 9951-9962 Larsen, P., Collart, F. and Dai, Y. (2015) Predicting Ecological Roles in the Rhizosphere using Metabolome and Transportome Modeling, PLOS One, 10 (9), e0132837. DOI: 10.1371/journal.pone.0132837. PMID: 26332409 Larsen, P., Collart. F., and Dai, Y. (2015). Metabolome of human gut microbiome is predictive of host dysbiosis. GigaScience, 4 (1), pp.42. DOI:10.1186/s13742-015-0084-3.

PMID: 26380076 Larsen, P., Sreedasyam, A., Trivedi,,G. Shalaka, S., Dai, Y., L. Cseke, L. and Collart, F. (2016) Multi-omics approach identifies molecular mechanisms of plant-fungus mycorrhizal interaction. Frontiers in Plant Science. DOI: 10.3389/fpls.2015.01061. PMC4717292. doi: 10.3389/fpls.2015.01061 Lin Meishan, Dennis Gessmann, Hammad Naveed, and Jie Liang Outer membrane protein folding and topology from a computational transfer free energy scale. J Am Chem Soc , 2016. 138(8):2592-601. http://dx.doi.org/10.1021/jacs.5b10307 Lin, C., Shi, J., Moore, A., and Khetani, S.R. (2016). Prediction of Drug Clearance and Drug-Drug Interactions in Microscale Cultures of Human Hepatocytes. Drug Metabolism and Disposition, 44(1), p. 127 Linninger, A., Tangen, K., Hsu, C., Frim, D. (2016) “Cerebrospinal fluid mechanics and its coupling to cerebrovascular dynamics”, Annual Review of Fluid Mechanics, 48, p219-257 Liu Y, Royston TJ, Klatt D, Lewandowski ED (2016). Cardiac Magnetic Resonance Elastography of the Mouse: Initial Results. Mag. Res. Med. DOI 10.1002/mrm.26030 Manne, Nandini D. P. K. BVSc & AH,; Arvapalli, Ravikumar; Nepal, Niraj; Thulluri, Srinivasarao; Selvaraj, Vellaisamy; Shokuhfar, Tolou; He, Kun; Rice, Kevin M.; Asano, Shinichi; Maheshwari, Mani; Blough, Eric R. (2015), Therapeutic Potential of Cerium Oxide Nanoparticles for the Treatment of Peritonitis Induced by Polymicrobial Insult in Sprague-Dawley Rats, Critical Care Medicine, 43, e477-e489, doi: 10.1097/CCM.0000000000001258 Manne, R Arvapalli, N Nepal, T Shokuhfar, KM Rice, S Asano, (2015), Cerium oxide nanoparticles attenuate acute kidney injury induced by intra-abdominal infection in Sprague–Dawley rats NDPK, Journal of nanobiotechnology 13 (1), 1-11 Mansy HA, Balk RA, Warren WH, Royston TJ, Dai Z, Peng Y, Sandler RH (2015). Effect of pneumothorax on pulmonary acoustic transmission. J. Applied Physiology. 119(3), 250-7. doi: 10.1152/japplphysiol.00148.2015 March, S., Ramanan, V., Trehan, K., Ng, S., Galstian, A., Gural, N., Scull, M.A., Shlomai, A., Mota, M.M., Fleming, H.E., Khetani, S.R., Rice, C.M., and Bhatia SN. (2015). Micropatterned Coculture of Primary Human Hepatocytes and Supportive Cells for the Study of Hepatotropic Pathogens. Nature Protocols, 10(12), p. 2027 Marques Isabella da Silva Vieira, Maria Fernanda Alfaro, Miki Taketomi Saito, Nilson Cristino da Cruz, Christos Takoudis, Richard Landers, Marcelo Ferraz Mesquita, Francisco Humberto Nociti Junior, Mathew T. Mathew, Cortino Sukotjo, Valentim Adelino Ricardo Barão, “Biomimetic coatings enhance tribocorrosion behavior and cell responses of commercially pure titanium surfaces,” Biointerfaces 11, 031008 (2016) Marques Isabella da Silva Vieira, Maria Fernanda Alfaro, Nilson Cristino da Cruz, Marcelo Ferraz Mesquita, Christos Takoudis, Cortino Sukotjo, Mathew T. Mathew, Valentim Adelino Ricardo Barão, “Tribocorrosion behavior of biofunctional titanium oxide films produced by micro-arc oxidation: Synergism and mechanisms,” Journal of the Mechanical Behavior of Biomedical Materials 60, 8-21(2016) Meshik Xenia, Xiaomeng Wu, Yiping Zhao, Joel Schwartz, Mitra Dutta and Michael Stroscio, SERS spectrum of the peptide thymosin-β4 obtained with Ag nanorod substrate, J. Raman Spectroscopy, 46, 194–196 (2015) Min S. Choi, Xenia Meshik, Souvik Mukherjee, Sidra Farid, Samuel Doan, Leigha Covnot, Mitra Dutta, and Michael A. Stroscio, Electrostatic Force Analysis, Optical Measurements, and Structural Characterization of Zinc Oxide Colloidal Quantum Dots Synthesized by Sol-gen Method, Journal of Applied Physics, 118 (19), 194304 (2015);http:// dx.doi.org.proxy.cc.uic.edu/10.1063/1.4935948 Montefiori L , R Wuerffel, D Roqueiro, B Lajoie, C Guo, T Gerasimova, S De, W Wood, KG Becker, J Dekker, J Liang, R Sen, AL Kenter. Extremely Long-Range Chromatin Loops Link Topological Domains to Facilitate a Diverse Antibody Repertoire. Cell Rep. , 2016. 14(4):896-906. doi: 10.1016/j.celrep.2015.12.083. Epub 2016 Jan 21 Moser T, T Shokuhfar, J Evans, (2015), Improved Environmental Control and Experimental Repeatability with New In-Situ Devices, Microscopy and Microanalysis 21 (S3), 949-950 Mukherjee Souvik, Xenia Meshik, Min Choi, Sidra Farid, Yi Lan, Shripriya Poduri, Debopam Datta, Ketaki Sarkar, Undarmaa Baterdene, Ching-En Huang, Yung Yu Wang, Peter Burke, Mitra Dutta, and Michael A. Stroscio, A graphene and aptamer based liquid gated FET-like electrochemical biosensor to detect Adenosine triphosphate, IEEE Transactions on Nanobioscience, 14(8) 967, (2015). Highlighted on journal web Nourmohammadzadeh M., Xing, Y., Lee, J., Bochenek, M.A., Mendoza-Elias, J.E., McGarrigle, J.J., Marchese, E., Chun-Chieh, Y., Eddington, D.T., Oberholzer, J., and Wang, Y. (2016), A microfluidic array for real-time live-cell imaging of human and rodent pancreatic islets, Lab on a Chip, 16 (8), 1466-1472, DOI: 10.1039/C5LC01173F Parthasarathy R, Chow KM, Derafshi Z, Fautsch MP, Hetling JR, Rodgers DW, Hersh LB, and Pepperberg DR. (2016). Reduction of amyloid-beta levels in mouse eye tissues by intravitreally delivered neprilysin. Experimental Eye Research, 138, 134-144 Patel Sweetu, Giovanni Francesco Solitro, Cortino Sukotjo, Christos Takoudis, Mathew T. Mathew, Farid Amirouche, Tolou Shokuhfar , “Nano-Topography and Surface Stress Analysis of Ti6Al4V Bio-Implant: An alternative Design for Stability,” Journal of Minerals, Metals and Materials Society 67(11), 2518-2533 (2015) Peng Y, Dai Z, Mansy HA, Henry BH, Sandler RH, Balk RA, Royston TJ (2015). Sound Transmission in Porcine Thorax through Airway Insonification, Med. Biol. Engin.

Comp. August. DOI: 10.1007/s11517-015-1358-8.

Qin W, G Zhao, M Carson, C Jia, H Lu, Knowledge-based three-body potential fortranscription factor binding site prediction IET Syst. Biol., 2016, Vol. 10, Iss. 1, pp. 23–29 Qin Wenyi, Cong Liu, Monsheel Sodhi, and Hui Lu, “Meta-analysis of sex differences in gene expression in schizophrenia”, BMC Systems Biology 2016, 10(Suppl 1):9 Ribeiro, A. R., Gemini-Piperni, S., Travassos, R., Lemgruber, L., C. Silva, R., Rossi, A. L., Shokuhfar. T, Granjeiro, J. M. (2016). Trojan-Like Internalization of Anatase Titanium Dioxide Nanoparticles by Human Osteoblast Cells. Nature Scientific Reports, 6, 23615. 2016, http://doi.org/10.1038/srep23615 Rogers S , KM Rice, NDPK Manne, T Shokuhfar, K He, V Selvaraj, (2015), Cerium oxide nanoparticle aggregates affect stress response and function in Caenorhabditis elegans, SAGE Open Medicine 3, 2050312115575387

Schwartz BL, Liu Y, Royston TJ, Magin RL (2016). Axisymmetric diffraction of a cylindrical transverse wave by a viscoelastic spherical inclusion. Journal of Sound and Vibration. 364, 222–233. http://dx.doi.org/10.1016/j.jsv.2015.11.023 Schwartz BL, Yin Z, Yasar TK, Liu Y, Khan AA, Ye AQ, Royston TJ, Magin RL (2016). Scattering and Diffraction of Elastodynamic Waves in a Concentric Cylindrical Phantom for MR Elastography. IEEE Trans. Biomed. Eng. doi:10.1109/TBME.2016.2527825 Selvaraj Sathees Kannan and Christos G Takoudis, “Scalable control program for multi-precursor flow-type atomic layer deposition system”, J. Vac. Sci. Technol. A 33, 013201 (2015) Selvaraj Vellaisamy, Kevin Rice, Niraj Nepal, Tolou Shokuhfar, Eric Blough, (2015), Inhibition of MAP kinase/ NF-kB mediated signaling and attenuation of lipopolysaccharide induced severe sepsis by cerium oxide nanoparticles, Biomaterials, 59, 160-171 Selvaraj Vellaisamy, Niraj Nepal, Steven Rogers, Nandini D.P.K. Manne, Ravikumar Arvapalli, Kevin M. Rice, Shinichi Asano, Erin Fankenhanel, J.Y. Ma, Tolou Shokuhfar, Mani Maheshwari, Eric R. Blough, (2015), Cerium oxide nanoparticles inhibit lipopolysaccharide induced MAP kinase/NF-kB mediated severe sepsis, Data Brief, 4, 105-115, doi: 10.1016/j.dib.2015.04.023 Selvaraj Vellaisamy, Niraj Nepal, Steven Rogers, Nandini DPK Manne, Ravikumar Arvapalli, Kevin M Rice, Shinichi Asano, Erin Fankenhanel, JY Ma, Tolou Shokuhfar, Mani Maheshwari, Eric R Blough, (2015), Lipopolysaccharide induced MAP kinase activation in RAW 264.7 cells attenuated by cerium oxide nanoparticles, Data in Brief (4), 96-99 Shirdar Mostafa Rezazadeh, Mohammad Mahdi Taheri , Hossein Moradifard, Ali Keyvanfar, Arezou Shafaghat, Tolou Shokuhfar, Sudin Izman, (2016), Hydroxyapatite–Titania nanotube composite as a coating layer on Co–Cr-based implants: Mechanical and electrochemical optimization, Ceramics International, 42, 6, 6942–6954 Taheri M, M. A. Kadir, Tolou Shokuhfar, A. Hamlekhan, M. R. Shirdar, F. Naghizadeh, (2015), Fluoridated hydroxyapatite nanorods as novel fillers for improving mechanical properties of dental composite: Synthesis and application, Materials and Design, 82, 119-125 Taheri Mohammad Mahdi, Mohammed Rafiq Abdul Kadir, Tolou Shokuhfar, Azhang Hamlekhan,Mahtab Assadian, Mostafa Rezazadeh Shirdar, Abolfazl Mirjalili, (2015), Surfactant-Assisted Hydrothermal Synthesis of Fluoridated Hydroxyapatite Nanorods” , Ceramic International, 8, 9867–9872 Thomas-Seale, L.E.J., Hollis, L., Klatt, D., Sack, I., Roberts, N., Pankaj, P. and Hoskins, P.R. (2016). The simulation of magnetic resonance elastography through atherosclerosis.

Journal of Biomechanics, 49, 1781–1788 Tobin, M., Geraghty, J., Engelhard, H., Linninger, A., Mehta, A. (2015) “Intermedullary spinal cord tumors: a review of current and future treatment strategies”, Journal of Neurosurgery, 39, p1-10 Venugopal I, Sirhan R, Basati S, Linninger A, (2016) “Prototype Biosensor for Detection of Myelin Basic Protein Biomarker in Hydrocephalus Diagnosis”, Sensor Letters 14 (1), 84-92 Venugopal, I., Pernal, S., Davalos, F., Ashkenaz, D., Linninger, A. (2016) “Quantum Dot Conjugated Magnetic Nanoparticles for Targeted Drug Delivery and Imaging”, Nano Biomedicine & Engineering 8, p24 Wang, W., Lockwood, K., Boyd, L.M., Davidson, M.D., Movafaghi, S., Vahabi, H., Khetani, S.R., and Kota, A.K. Superhydrophobic Coatings with Edible Materials. (2016).

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AWARDED PATENTS OF CORE FACULTY PATENT HOLDERS FROM THE DEPARTMENT

TITLE OF THE AWARDED PATENT

Hananeh Esmailbeigi

Tongue-Computer Interface

John Hetling

Pixelated full-field electroretinogram stimulus source for probing local retinal function

John Hetling

Pattern stimulus source for visual function testing

John Hetling

Device for electrophysiological recording from the eye

James Patton

Multi-Active-Axis, Non-Exoskeletal Rehabilitation Device

Tolou Shokuhfar

Compositions, methods and devices for generating nanotubes on a surface

Christos Takoudis

Multi - Metal Films, Alternating Film Multilayers, Formation Methods and Deposition System

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50 Years UIC Bioengineering

UIC Bioengineering Department Is 50 Years Old: Looking Back at its Founding Head Lawrence Stark On the occasion of the 50th anniversary of the undergraduate and graduate programs in bioengineering at the University of Illinois at Chicago, a special symposium was held on November 20, 2015 to review past and current contributions of faculty within the department to the research field of bioengineering and to pay tribute to the department founders, the original faculty hired by Dr. Larry Stark in 1965, some of whom were present at the symposium. This was also an opportunity to review Dr. Stark’s broad-reaching contributions to the field of bioengineering. Complementary to this symposium, faculty and former faculty of the (now) Richard and Loan Hill Department of Bioengineering have authored a special issue of Critical Reviews in Biomedical Engineering that recounts technical advances in bioengineering pioneered at UIC, and are preparing a web site that will include highlights from the recorded symposium and interviews with faculty and students, past and present, recounting their experiences at UICC/UIC.

Dr. John W. Ahlen, the first student to receive a BS degree from the newly formed UICC Department of Bioengineering in 1969 talked about his experiences as a student in those early days.

Dr. Bert L. Zuber, faculty member of UICC/UIC Bioengineering from 1965 – 1999 shared his experiences.

Faculty and students of UICC/UIC Bioengineering, past and present, gathered for a group photo.

Seated left to right: Miiri Kotche, PhD (Clinical Associate Professor of Bioengineering), Robert Kenyon, PhD (Professor of Computer Science and Bioengineering), John W. Ahlen, PhD (first BS student of UICC/UIC Bioengineering), Richard L. Magin, PhD (University Distinguished Professor and former Head of Bioengineering), Bert L. Zuber, PhD (Professor Emeritus of Bioengineering), Earl Gose, PhD (Professor Emeritus of Bioengineering), Brenda Russell, PhD (Professor Emerita of Bioengineering and Physiology & Biophysics). Standing middle row left to right: James Lee, PhD (Associate Professor of Bioengineering), John Hetling, PhD (Associate Professor of Bioengineering), Jie Liang, PhD (Richard and Loan Hill Professsor of Bioengineering), Terry Layton, PhD (Senior Lecturer of Bioengineering), William Pietrzak, PhD (BS 1977 and PhD 1988 degrees from UICC/UIC Bioengineering, member of External Advisory Board), Thomas J. Royston, PhD (Professor and Head of Bioengineering), Xincheng Yao, PhD (Professor of Bioengineering), G. Ali Mansoori, PhD (Professor of Bioengineering and Chemical Engineering). Standing back row left to right: Hananeh Esmailbeigi, PhD (Clinical Assistant Professor of Bioengineering), Salman Khetani, PhD (Associate Professor of Bioengineering), Robert Eisenberg, PhD (Chair Emeritus and Professor of Molecular Biophysics & Physiology at Rush, Professor of Bioengineering), James L. Patton, PhD (Professor of Bioengineering), Christos Takoudis, PhD (Professor of Bioengineering and Chemical Engineering) Tolou Shokuhfar, PhD (Associate Professor of Bioengineering), Richard Penn, MD (Affiliate Professor of Bioengineering), Irv Miller, PhD (Professor Emeritus of Bioengineering).

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