Biomedical Science and Engineering by Katharine Bale

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The following sectional catalogs are available from CRC Press. For a copy, please contact your local representative or CRC Press office. Agricultural and Life Sciences Catalog no. CATAGL • ISBN: 978-0-8493-3864-9

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Table of Contents Biomedical Science Cell Biology........................................................................................................................................................3 Developmental Biology......................................................................................................................................6 Genetics............................................................................................................................................................8 Immunology.....................................................................................................................................................10 Lab Animal Science.........................................................................................................................................13 Microbiology....................................................................................................................................................17 Molecular Biology............................................................................................................................................25 Neuroscience...................................................................................................................................................27 Nutrition Science.............................................................................................................................................41 Biomedical Engineering Biochemistry....................................................................................................................................................47 Biomaterials & Medical Devices......................................................................................................................56 Biomechanics..................................................................................................................................................64 Biomedical Engineering..................................................................................................................................67 Biomedical Imaging.........................................................................................................................................75 Biophysics.......................................................................................................................................................80 Biotechnology..................................................................................................................................................83 Methods & Instrumentation..............................................................................................................................88 Nanobiotechnology.........................................................................................................................................92 Tissue Engineering..........................................................................................................................................94

Biomedical Science and Engineering â&#x20AC;&#x201C; 2009

Product Listings

Pharmacology Biopharmaceuticals.........................................................................................................................................96 Drug Discovery & Development......................................................................................................................98 Manufacturing & Quality Assurance..............................................................................................................104 Pharmaceutical Science................................................................................................................................105 Pharmacology................................................................................................................................................106 Pharmacy.......................................................................................................................................................113 Math & Statistics in Biomedicine Bioinformatics................................................................................................................................................115 Biostatistics....................................................................................................................................................123 Mathematics for Biology & Medicine.............................................................................................................131 Title Index.............................................................................................................................................................133 Author Index.........................................................................................................................................................137 Sales Agents........................................................................................................................................................142 Order Form...........................................................................................................................................................144 Ordering Information / Call for Authors........................................................................................ Inside Back Cover

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Advances in Biopreservation

Animal Lectins

Edited by

A Functional View

Institute of Biomedical Technology, New York, USA

John M. Baust

Cell Preservation Services, Inc., Owego, New York, USA

Written by recognized international leaders in biopreservation, this book expertly integrates recent molecular-based discoveries with classically-based biopreservation basics, offering a new look at advances in the emerging regenerative medicine arena. In addition to general concepts of biopreservation, it includes chapters detailing subspecialty principles, such as biologically active macromolecules, stem cells, and gene therapy, as well as new protocols for cell, tissue, and organ preservation. Integrating the concepts of first generation cryopreservation with the new paradigm, this book is a fundamental reference to the latest advances in the field. Catalog no. 2772, ISBN: 978-0-8493-2772-8 2007, 7 x 10, 426 pp. Suggested Price: $209.95 / £117.00

Edited by

Gerardo R. Vasta and Hafiz Ahmed

University of Maryland and Biotechnology Institute, College Park, USA

Lectins are currently of interest in the research community because of their wide variety of properties and potential applications in pharmacology, immunology, and cancer therapy. Identifying lectins and their ligands is the particular focus of intense study. Featuring contributions from recognized experts, Animal Lectins: A Functional View presents up-to-date knowledge of the biological roles of animal lectins, including glycoprotein folding, sorting, and targeting; cell adhesion; embryogenesis; cell-cell interactions and signaling; as well as recognition and effector functions in innate immunity. This book also explores the structural basis of proteincarbohydrate interactions.

Cell Biology

John G. Baust

Catalog no. 7269, ISBN: 978-0-8493-7269-8 January 2009, 7 x 10, 596 pp. Suggested Price: $199.95 / £111.00

Antiangiogenic Cancer Therapy

Angiogenesis

From Basic Science to Clinical Applications

Edited by

Napoleone Ferrara

Roy S. Herbst and James L. Abbruzzese

Genentech Inc., South San Francisco, California, USA

University of Texas, M.D. Anderson Cancer Center, USA

Integrating the latest advances in basic science, this book reviews the status of the clinical applications of angiogenic growth factors and inhibitors. Angiogenesis: From Basic Science to Clinical Applications explores current molecular and genetic findings on the regulation of angiogenesis, discusses the results of clinical trials, and identifies the pathological conditions that are most likely to benefit from such treatments. Edited by a foremost researcher in the field, the book includes contributions from experts in a variety of disciplines, supplemented by illustrations and photographs. This unique combination of information offers a truly a state-of-the-art review of the science.

AntiAngiogenic Cancer Therapy provides information on the process of angiogenesis and its role in tumor growth and metastasis. It compiles the work of leading experts to explore angiogenesis inhibitors under clinical investigation, as well as early agents used in preclinical studies. It discusses the unique aspects of targeting and inhibiting angiogenesis and the challenges associated with clinical development of angiogenesis inhibitors including trial design and surrogate marker endpoints. The chapters are organized to allow readers easy access to the fundamental concepts of angiogenesis and information on the complexities associated with targeting angiogenesis for specific types of cancer.

Catalog no. 2844, ISBN: 978-0-8493-2844-2 2007, 6-1/8 x 9-1/4, 280 pp. Suggested Price: $164.95 / £92.00

Catalog no. 2799, ISBN: 978-0-8493-2799-5 2008, 7 x 10, 864 pp. Suggested Price: $209.95 / £117.00

Darren W. Davis

Apocell, Inc., Houston, Texas, USA

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For more information and a complete list

Artificial Cells, Cell Engineering and Therapy Edited by

Edited by

Wolfram Siede

University of North Texas, Fort Worth, USA

Yoke Wah Kow and Paul W. Doetsch

S. Prakash

Cell Biology 4

DNA Damage Recognition

McGill University, Montreal, Quebec, Canada

Emory University School of Medicine, Atlanta, Georgia, USA

This authoritative reference provides a detailed study of the most up-to-date developments in artificial cells, cell engineering, and cell therapy. Broken down into four sections, the book covers the design, engineering, and uses of artificial cells and assesses the clinical relevance of artificial cells and cell engineering. Highlights include liposomes, nanocapsules, stem cell engineering for therapy, cell therapy approaches for spinal cord injury, treatment of cancer, insulin delivery, and pharmaceutical and industry to name just a few. This is a highly dynamic sector with growing interest in the use of engineered cells in controlled release of active drugs and other therapeutic agents.

Covering an array of topics, this authoritative work summarizes recent developments, while providing timely reviews on the molecular mechanisms employed by cells to distinguish between damaged and undamaged sites and stimulate the appropriate repair pathways. Richly illustrated, this guide discusses the theoretical aspects of DNA damage recognition, exploring those that are relevant for various regulatory responses, such as transcriptional regulation or checkpoint arrest. It also details key concepts in the recognition of bulky DNA base damage, reviews the excision repair of non-bulky base damage, and covers short-patch repair and the recognition and repair of single- and double-strand breaks.

Catalog no. WP9111, ISBN: 978-0-8493-9111-8 2007, 6 x 9, 516 pp. Suggested Price: $259.95 / £144.00

Catalog no. DK3110, ISBN: 978-0-8247-5961-2 2006, 7 x 10, 872 pp. Suggested Price: $209.95 / £117.00

Dietary Modulation of Cell Signaling Pathways

Gene and Cell Therapy

Edited by

Young-Joon Surh, Zigang Dong, Enrique Cadenas, and Lester Packer

Therapeutic Mechanisms and Strategies, Third Edition

University of Southern California, Los Angeles, USA

Edited by

Series: Oxidative Stress and Disease

Baylor College of Medicine, Houston, Texas, USA

A comprehensive review of recent research findings, Dietary Modulation of Cell Signaling Pathways focuses on nutrient-gene interactions and the intracellular signaling network. Comprehensively covering dietary modulation of cell signaling, leading experts address the dietary modulation of particular gene expression systems. The book highlights the underlying molecular and cellular mechanisms that involve upstream signaling molecules, such as kinases and transcription factors in the context of their therapeutic potential. It describes nutrients’ actions on the activation of an antioxidant and inflammatory transcription factor and the induction of their target gene expression. Catalog no. 8148, ISBN: 978-0-8493-8148-5 January 2009, 6 x 9, 504 pp. Suggested Price: $149.95 / £83.00

Nancy Smyth Templeton

This latest edition of Gene and Cell Therapy provides comprehensive coverage of all aspects of the tools and state-of-theart technologies that are currently available in this field. Written by international leaders, this third edition features 12 additional chapters that address such new topics as gene and cell therapies for diabetes and cardiovascular disease, relevant nanotechnologies, siRNA therapeutics, dendrimers, clinical trials, human embryonic stem cell research, tissue engineering, and novel polymers. All chapters in the text have been substantially updated and revised to reflect the latest information available in the field. Catalog no. 8768, ISBN: 978-0-8493-8768-5 January 2009, 8-1/2 x 11, 1120 pp. Suggested Price: $229.95 / £128.00

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

Lipid-Mediated Signaling

Osmotic and Ionic Regulation

Eric J. Murphy and Thad A. Rosenberger

Edited by

Cells and Animals

Methods in Signal Transduction Series

David H. Evans

University of Florida, Gainesville, USA

Reviewing the most current research in this rapidly expanding yet resource-limited field, Lipid-Mediated Signaling provides a much needed examination of a decade’s worth of research tying pathologic disorders such as cancer and autoimmunity problems to aberrant or deregulated signal transduction processes. It considers particular cells, tissues, and organ systems, and discusses recent efforts to identify the various signaling proteins that govern their behavior. The book divides its material under five topics: fatty acid metabolism, eicosanoid formation, acyl hydrolase activity, phospholipids and nuclear signaling, and gene expression. It includes contributions from a number of pioneering experts in this emerging field.

Osmotic and Ionic Regulation: Cells and Animals not only fills a 40 year gap in the literature, but also presents a markedly changed field with new approaches, outlooks, and findings. After discussing the chemistry of ions in solution, membrane transporters, and cellular ion and volume regulation, the book is organized around various animal taxa. The text provides a thorough discussion of the physiology and molecular biology of the membrane transporters. Each chapter reviews everything from the basic anatomy and ecophysiology to the molecular mechanisms and control. The extensive references contained in the book provide an access point to the primary literature.

Catalog no. 8141, ISBN: 978-0-8493-8141-6 May 2009, 6-1/8 x 9-1/4, 480 pp. Suggested Price: $159.95 / £97.00

Catalog no. 8030, ISBN: 978-0-8493-8030-3 January 2009, 7 x 10, 606 pp. Suggested Price: $129.95 / £72.99

Nucleotides and Regulation of Bone Cell Function

Signal Transduction in the Retina Edited by

Steven J. Fliesler

Edited by

VA Western New York Healthcare System, Buffalo New York, USA

Geoffrey Burnstock

Oleg G. Kisselev

Autmonomic Neuroscience Institute, London, UK

Timothy R. Arnett

Saint Louis University Eye Institute, Missouri, USA

University College London, UK

Methods in Signal Transduction Series

Written by the pioneers who have energized the research, Nucleotides and Regulation of Bone Cell Function covers all aspects of purinergic signaling with regard to osteoblasts, osteoclasts, and chondrocytes, providing an exploration into how nucleotides act on skeletal cells. It reveals the distribution of receptors for purines and pyrimidines in both neuronal and non-neuronal cells, considers purinergic and P2 nucleotide receptor signaling in osteoclasts, and examines the role of signaling in regulating cartilage metabolism and chondrocyte function. It also considers the pathophysiologic implications of the findings, and discusses the potential of purinerelated therapies for a variety of diseases.

Beginning with the molecular mechanisms of vertebrate phototransduction, this volume presents the structure of phototransduction cascade components at atomic resolution, as well as molecular interactions in multi-protein complexes and novel cell-based strategies for understanding signal shut-off and light adaptation. It discusses non-visual phototransduction and the role of melanopsin in adaptive photoresponses and circadian clock regulation. It also compares the visual signaling processes of vertebrates and invertebrates; investigates signaling in progenitor cells and cell-cell communication in developing cells, and discusses lipid-derived mediators as well as the participation of retinal pigment epithelium in neuronal survival.

Catalog no. 3368, ISBN: 978-0-8493-3368-2 2007, 6-1/8 x 9-1/4, 207 pp. Suggested Price: $185.95 / £103.00

Cell Biology

University of North Dakota, Grand Forks, USA

Catalog no. 7315, ISBN: 978-0-8493-7315-2 2008, 6-1/8 x 9-1/4, 408 pp. Suggested Price: $169.95 / £98.00

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For more information and a complete list Atlas of Human Central Nervous System Development Cell Biology / Developmental Biology

Signaling by Toll-Like Receptors Edited by

Gregory W. Konat

West Virginia University, Morgantown, USA Methods in Signal Transduction Series

The recent discovery of an ancient family of toll-like receptors (TLRs) in the immune system has substantially enhanced the potential for a variety of therapies, for failing immune systems, which leaves the body open to infection, or over-active ones, which can lead to chronic inflammation. Signaling by Toll-Like Receptors provides a comprehensive review of important techniques in molecular biology, cell biology, biochemistry, genetics, and immunology, and their critical application to the study of toll-like receptor structure, biological function, and the intracellular signaling triggered by these receptors, as well as their promise in uncovering effective pharmaceutical targets. Catalog no. 43188, ISBN: 978-1-4200-4318-1 2008, 6-1/8 x 9-1/4, 224 pp. Suggested Price: $149.95 / £83.00

Analysis of Growth Factor Signaling in Embryos

5 Volume Set

Shirley A. Bayer and Joseph Altman Indianapolis, Indiana, USA

Available now as a set, this award-winning series provides a complete record of the development of the human central nervous system from spinal cord gestation through the third trimester. The contents are organized by coronal, sagittal, and horizontal planes of sectioning, ensuring pictorial representation of nearly every structure in the developing brain. Each volume provides two-page spreads containing high resolution black and white images on one side and ghost images on the other with unabbreviated labels that clearly identify each structure. The final volume summarizes major events of CNS development and offers a theoretical account of the morphogenetic processes involved.

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Five Volume Set Catalog no. 68008, ISBN: 978-1-4200-6800-9 2008 Suggested Price: $749.00 / £416.00

The Spinal Cord from Gestational Week 4 to the 4th Postnatal Month Catalog no. 1420, ISBN: 978-0-8493-1420-9 2002, 8-1/2 x 11, 256 pp. Suggested Price: $219.95 / £122.00

Edited by

The Human Brain During the Third Trimester

Harvard Medical School, Boston, Massachusetts, USA

Catalog no. 1421, ISBN: 978-0-8493-1421-6 2004, 392 pp. Suggested Price: $199.95 / £117.00

6 Malcolm Whitman Amy Sater

University of Houston, Texas, USA Series: Methods in Signal Transduction Series, 8

Focusing on specific pathways or pathway components, Analysis of Growth Factor Signaling in Embryos provides the methods and guidelines for experimental design to study cell signaling in vertebrate embryos. With contributions from top researchers, the book incorporates molecular, cellular, and systems analysis while discussing signal transduction, protein phosphorylation, embryogenesis, pattern formation, and morphogenesis. It also covers multiple types of signaling components, including receptors, GTPases, and effector kinases, and discusses all of the major vertebrate embryonic model systems, such as Xenopus, mouse, zebrafish, and chick. This book provides a foundation for further explorations of the cellular regulatory mechanisms governing vertebrate embryonic development. Catalog no. 3165, ISBN: 978-0-8493-3165-7 2007, 6-1/8 x 9-1/4, 435 pp. Suggested Price: $175.95 / £98.00

The Human Brain During the Second Trimester Catalog no. 1422, ISBN: 978-0-8493-1422-3 2005, 8-1/2 x 11, 384 pp. Suggested Price: $179.95 / £103.00

The Human Brain During the Late First Trimester Catalog no. 1423, ISBN: 978-0-8493-1423-0 2006, 8-1/2 x 11, 592 pp. Suggested Price: $189.95 / £109.00

The Human Brain During the Early First Trimester Catalog no. 1424, ISBN: 978-0-8493-1424-7 2008, 8-1/2 x 11, 536 pp. Suggested Price: $169.95 / £98.00

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Medicine and Evolution Clinical Embryology A Color Atlas and Text Murray Brookes

Current Applications, Future Prospects Edited by

Sarah Elton and Paul O’Higgins

Hull York Medical School , University of York, UK

Anthony Zietman

Massachusetts General Hospital, Salem, USA

Series: Society for the Study of Human Biology

Clinical Embryology: A Color Atlas and Text unravels and illuminates the complex process of both normal and abnormal prenatal human developments. Vivid color drawings and photographs, many in three dimensions, clarify difficult concepts and bring contemporary clinical examples to life. Each section of the atlas includes pertinent case reports, clinical photographs, radiologic studies, and examples from the pathology lab that emphasize the importance of embryology across the field of medicine.

Highlighting exciting areas of research into the evolutionary basis of health and disease, this book employs a multidisciplinary perspective to emphasize practical applications and address how evolutionary medicine may inform clinical practice as well as medical education. Presenting new data and weighing relevant evidence, the book introduces novel viewpoints on nutrition, diabetes, fertility, pediatrics, immune response, and psychiatry. It discusses when evolutionary viewpoints might and might not be useful and conducts critical debates on controversial areas such as race-based pharmaceuticals.

Catalog no. 1255, ISBN: 978-0-8493-1255-7 1999, 8-1/2 x 11, 352 pp., Migration Error Code Suggested Price: $57.95 / £31.99

Human Variation

From the Laboratory to the Field Edited by

C.G. Nicholas Mascie-Taylor

Catalog no. 51342, ISBN: 978-1-4200-5134-6 2008, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $129.95 / £72.99

Methods in Reproductive Aquaculture

Marine and Freshwater Species

University of Cambridge, UK

Edited by

Akira Yasukouchi

Elsa Cabrita and Vanesa Robles

Kyushu University, Fukuoka, Japan

University of Algarve, Faro, Portugal

Stanley Ulijaszek

Paz Herráez

University of Oxford, UK

University of Leon, Spain

Series: Society for the Study of Human Biology

Series: Marine Biology

Unique in its approach, this work updates our understanding of human variation by employing both laboratory and field perspectives. Written by a team of scientists representing four continents, it reviews the way we examine and analyze human variation with special reference to genetics, growth and development, and physiology. In describing the main factors influencing human variation, it delves into environmental plasticity, lifestyle, and heritability of characteristics. A significant part of the focus is on the methodology and analytical techniques, detailing field and laboratory approaches, and looking at how the two perspectives complement each other.

Providing an overview of available techniques for fish farmers and researchers, Methods in Reproductive Aquaculture addresses ways to improve depleted stocks of endangered fish and other species. This practical guide provides a review of gamete extraction, sperm collection, and egg stripping in different species. It then focuses on sperm and egg quality characteristics before presenting information on the materials and facilities required for gamete preparation and freeze-thawing procedures. It includes guidance on cryopreservation as a technique for gamete management. A final section reviews important aspects of gamete handling, before, during, and after fertilization and incubation.

Catalog no. 84712, ISBN: 978-1-4200-8471-9 July 2009, 6-1/8 x 9-1/4, 250 pp. Suggested Price: $99.95 / £60.99

Developmental Biology

University of London, UK

Catalog no. 8053, ISBN: 978-0-8493-8053-2 January 2009, 6-1/8 x 9-1/4, 568 pp. Suggested Price: $109.95 / £59.99

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For more information and a complete list Textbook

The Physiology of Fishes Third Edition Edited by

Developmental Biology / Genetics

David H. Evans

University of Florida, Gainesville, USA

Cancer Epigenetics

James B. Claiborne

Edited by

Georgia Southern University, Statesboro, USA Series: Marine Biology

Trygve Tollefsbol

University of Alabama at Birmingham, USA

With the genomic revolution and a heightened understanding of molecular biology, we now have the tools and the knowledge to apply a fresh approach to the study of fishes. Consequently, The Physiology of Fishes, Third Edition is not merely another updating, but an entire reworking of the original. To satisfy that need for a fresh approach, the editors have employed a new set of expert contributors steeped in the very latest research. In addition to new chapters on gas transport, temperature physiology, and stress, as well as one dedicated to functional genomics, readers will discover that many of these new contributors approach their material with a contemporary molecular perspective.

It has become increasingly apparent during the past few decades that heredity is not the sole determining factor in disease development. As a result, the field of epigenetics is now the focus of many of the most exciting and significant advances in cancer research. Providing the most up-to-date and relevant information available, this text presents in-depth discussions of DNA methylation analysis and cancer, histone modifications and cancer, and other epigenetic aspects of cancer. This book explores the role of epigenetics in the diagnosis, prognosis, and therapy of cancer and offers a comprehensive overview of current and potential new epigenetics advancements.

Catalog no. 2022, ISBN: 978-0-8493-2022-4 2006, 7 x 10, 616 pp. Suggested Price: $119.95 / £69.99

Catalog no. 45792, ISBN: 978-1-4200-4579-6 January 2009, 7 x 10, 472 pp. Suggested Price: $149.95 / £83.00

The Aspergilli

Genomics, Medical Aspects, Biotechnology, and Research Methods 8

Edited by

Gustavo H. Goldman

Universidade de Sao Paolo, Brazil

Epigenetics in Biology and Medicine

Stephen A. Osmani

Edited by

Ohio State University, Columbus, USA Series: Mycology

Manel Esteller

Spanish National Cancer Centre, Madrid, Spain

Based on recently revealed genomic sequences, this pioneering text provides a comprehensive analysis of research that explains the main biological attributes of this species. Including the contributions of elite researchers, the text moves from basic biology to examine genomic structure, and includes a comparison of metabolic abilities among different Aspergillus, as well as other species. It fills the need for centralized information on a genus that in addition to offering significant genetic insight, has a profound impact on agriculture, human health, industry, and pharmacology. The book comes with a CD containing color illustrations to supplement the text. Catalog no. 9080, ISBN: 978-0-8493-9080-7 2008, 7 x 10, 576 pp. Suggested Price: $149.95 / £86.00

Epigenetic changes are essential to normal development, but these changes can also cause problems including the disabling of genes that suppress tumors. At present more than a dozen drugs that target epigenetic changes are in clinical trials. This volume offers a comprehensive overview of epigenetics, both in normal functions and disease states. It presents contributions from international experts, addressing both theoretical and methodological issues. It discusses cell biology and the role of epigenetics in human, animal, and plant diseases. The text also covers DNA methylation inhibitors, histone modifications, and epigenomics, as well as the impact that diet has on epigenetic changes. Catalog no. 7289, ISBN: 978-0-8493-7289-6 January 2009, 6-1/8 x 9-1/4, 312 pp. Suggested Price: $149.95 / £83.00

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Genomic Approaches for Cross-Species Extrapolation in Toxicology

Gaucher Disease

Edited by

William H. Benson

Anthony H. Futerman

Weizmann Institute of Science, Rehovot, Israel

National Health & Environmental Effects Research Laboratory, Gulf Breeze, Florida, USA

Ari Zimran

Richard T. Di Giulio

The most current and comprehensive reference available, Gaucher Disease outlines current research on the biochemistry and pathology of lysosomal storage disorders and covers diverse topics including animal models, crystallography, imaging, and radionuclide evaluation. It addresses treatments such as enzyme replacement therapy, as well as emerging therapies. With contributions from world-renowned experts, this book includes discussions on patient management, the ethics of research, and the use of expensive therapies in treating orphan diseases. In September of 2007, this book received a commendation in the Haematology category of the 2007 British Medical Association Medical Book Competition.

Covering computational approaches and cross-species extrapolations, Genomic Approaches for Cross-Species Extrapolation in Toxicology outlines a research agenda utilizing emerging technologies in omics and computational biology in order to elucidate similarities and differences among species, relate stressormediated responses to adverse outcomes, and extend this science into innovative approaches to risk assessment and regulatory decisionmaking. The book provides a meaningful starting point for future work regarding the use of emerging molecular and computational approaches for cross-species extrapolations.

Duke University, Durham, North Carolina, USA

Catalog no. 3816, ISBN: 978-0-8493-3816-8 2007, 6-1/8 x 9-1/4, 544 pp. Suggested Price: $179.95 / £103.00

Catalog no. 4334X, ISBN: 978-1-4200-4334-1 2007, 6-1/8 x 9-1/4, 216 pp. Suggested Price: $114.95 / £63.99

Handbook of New Technologies for Genetic Improvement of Legumes

Genetics and Randomness

Genetics

Gaucher Clinic, Jerusalem, Israel

Edited by

Anatoly Ruvinsky

P. B. Kirti

University of New England, Australia

University of Hyderabad, India

With the revolutionary explosion of genetic information in recent decades, it is important to realize the underlying limitations of scientific predictions in genetics. Avoiding unnecessary technical details, this book helps readers accept and embrace a probabilistic view and understand the role of randomness in critical biological processes. It explores the nature of genetic uncertainty from different points of view and at different levels of biological organization. The book also traces the origin of some ideas of randomness starting from the basics of quantum mechanics and molecular genetics to modern evolutionary genetics and the philosophy of mathematics. Catalog no. 78852, ISBN: 978-1-4200-7885-5 June 2009, 6-1/8 x 9-1/4, 176 pp. Suggested Price: $89.95 / £54.99

Comprehensive in its approach, this book presents the latest research on all aspects of genetically modified legume production. With contributions from over 90 international experts, this eyeopening resource offers an in-depth exploration of key topics such as genetic transformation technology, suppression-subtractive hybridization, c-DNA micro arrays, molecular mapping, tagging regulatory elements, and real-time PCR. The text also features a wealth of detailed references and informative tables to clearly explain pertinent data. With groundbreaking essays from some of the discipline’s most renowned experts, it is a source for up-to-date accounts of genetic manipulation but their uses. Catalog no. HW13935, ISBN: 978-1-56022-308-5 2008, 6 x 9, 680 pp. Suggested Price: $139.95 / £77.99 Also Available in Soft Cover

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For more information and a complete list Nonhuman DNA Typing Theory and Casework Applications Edited by

Heather Miller Coyle

Genetics / Immunology 10

Regulation of Gene Expression by Small RNAs

University of New Haven, West Haven, Connecticut, USA

Edited by

Series: International Forensic Science and Investigation, 16

Beckman Research Institute, Duarte, California, USA

Rajesh K. Gaur and John J. Rossi

Combining science, case examples, legal decisions, and references, Nonhuman DNA Typing: Theory and Casework Applications provides an introduction to the basic science underlying the emerging field of non-human DNA typing. It demonstrates the recognition, collection, and preservation of biological evidence, techniques of DNA fingerprinting, and DNA profiling. The book describes the STR analysis of canine and feline samples, insects, and fungi and their function as evidence. The text considers the development of method in testing animal evidence, soil DNA typing, and the use of DNA typing in wildlife investigations. A useful appendix includes an overview of the history of forensic serology and DNA.

Recent research demonstrates that defects in the processing mechanisms of small non-coding RNAs are linked to various human diseases. This text explores the latest research on microRNAs and their functional roles in cells and organisms. Written by international experts, discussions include the identification, characterization, and structure-function analysis of microRNAs; the study of microRNAs in development, cancer, and viruses; and the applications of microRNAs with respect to gene regulation, functional genomics and therapeutics. This book is a valuable reference for established researchers and is also suitable for postdoctoral and clinical fellows and graduate students.

Catalog no. DK2451, ISBN: 978-0-8247-2593-8 2008, 6-1/8 x 9-1/4, 248 pp. Suggested Price: $144.95 / £79.99

Catalog no. 9169, ISBN: 978-0-8493-9169-9 April 2009, 6-1/8 x 9-1/4, 440 pp. Suggested Price: $149.95 / £89.00

Paramecium

Genetics and Epigenetics G.H. Beale

Chamberlain Nursing Home, Edinburgh, UK

John R. Preer, Jr.

Atlas of Immunology Second Edition

Julius M. Cruse and Robert E. Lewis

Indiana University, Bloomington, USA

University of Mississippi Medical Center, Jackson, USA

Taking a rather unconventional view of genetics, this book explores how to use paramecium as a basis for studying complex cells. It describes the morphology, reproduction, and life cycle stages of paramecium and outlines methods for studying genetic processes, such as Mendelian, caryonidal, and cytoplasmic transmissions. The authors offer detailed accounts of bygone hypotheses, such as the plasmagene and metagon hypotheses, and examine epigenetic mechanisms in antigenic expression and cortical inheritances. They also explore interesting new work on ciliate genetics, including a gene cloning method via functional complementation and homologydependent inheritance.

With more than 1,250 computer-generated figures, line drawings, and photographs, the Atlas of Immunology clearly demonstrates that “a picture is worth a thousand words.” This second edition provides a thorough and up-to-date treatment of all the concepts needed to comprehend contemporary immunology. The subject matter ranges from photographs of historical figures to molecular structures of recently characterized cytokines, major histocompatibility complex molecules, immunoglobins, and molecules of related interest. No other publication provides the breadth and detail of illustrated immunological concepts. It puts visual images of immunological information within easy reach.

Catalog no. TF1277, ISBN: 978-0-415-25785-5 2008, 6-1/8 x 9-1/4, 216 pp. Suggested Price: $99.95 / £55.99

Catalog no. 1567, ISBN: 978-0-8493-1567-1 2004, 8-1/2 x 11, 856 pp. Suggested Price: $99.95 / £57.99

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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Chemical and Biological Properties of Food Allergens

Desk Reference for Hematology

Lucjan Jedrychowski

Edited by

Series: Chemical & Functional Properties of Food Components

N.K. Shinton

University of Warwick, Coventry, UK Series: Desk References

The problem of food allergies is becoming a significant epidemiological, sociological, and economic issue. Addressing chemical, analytical, and medical aspects, Chemical and Biological Properties of Food Allergens explains the basic mechanisms of allergenic reactions in humans, the molecular background of these mechanisms, and the problems of food tolerance and intolerance. Evaluating the current research literature in a concise and userfriendly format, this book characterizes basic groups of food allergens, pinpoints the most common, and describes various technological and biotechnological methods of lowering the immunoreactive and allergenic properties of foods.

A cross between a dictionary and an encyclopedia, this second edition presents a thorough examination of hematology. The 1500 alphabetically listed articles provide quick and easy access to expert information, the 150 tables contain precise data, and the 100 figures clarify the text. The book contains 500 references on state-of-theart guidelines and recent developments. New information includes revised articles emphasizing genetics, physiology, pathological mechanisms; updated coverage of treatments for leukemia, lymphoma, coagulation, and thrombotic disorders; and a hundred completely new articles, new illustrations, and new explanatory diagrams as well as revised tables.

Catalog no. 5855X, ISBN: 978-1-4200-5855-0 June 2009, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $159.95 / £97.00

Catalog no. 3393, ISBN: 978-0-8493-3393-4 2008, 7 x 10, 1032 pp. Suggested Price: $179.95 / £103.00

Cytokines

Handbook of Human Immunology

Stress and Immunity, Second Edition

Immunology

Inst of Animal Reproduction & Food Research, Olsztyn, Poland

Second Edition

Second Edition Edited by

Edited by

Nicholas P. Plotnikoff, Robert E. Faith, Anthony J. Murgo, and Robert A. Good

Maurice R.G. O’Gorman

The Children’s Memorial Hospital, Chicago, Illinois, USA

Albert D. Donnenberg

University of South Florida All Children’s Hospital, St. Petersburg, USA

Hillman Cancer Center, Pittsburgh, Pennsylvania, USA

Completely revised, Cytokines: Stress and Immunity, Second Edition offers 16 entirely new chapters, which document developments across a number of fields, including immunology, pharmacology, and psychiatry. Delving into the cytokine relation to stress and depression, this seminal work details all clinically relevant cytokines, including interleukins, interferons, enkephalins, and endorphins. It explores cytokine-hormone interactions and the clinical implications of those interactions on the immune, endocrine, and central nervous systems, clearly documenting how cytokine activity is implicated in fueling the vicious circle of depression and illness in a variety of mental and physical diseases.

Since the publication of the first edition in 1997, major scientific achievements have elucidated our understanding of the complexities of the human immune system. This second edition compiles the major breakthroughs of the past decade including dramatic increases in the number of recognized “clusters of differentiation” on the surface of leukocytes and associated cells, establishment of an entire new chemokine and chemokine receptor nomenclature system, and discovery of more than 30 “lymphokines.” The text emphasizes clinically relevant immunological parameters, and clarifies the basic principles underlying immune system assays, as well as applications and interpretations of immune tests.

Catalog no. 2074, ISBN: 978-0-8493-2074-3 2007, 6-1/8 x 9-1/4, 405 pp. Suggested Price: $114.95 / £63.99

Catalog no. 1984, ISBN: 978-0-8493-1984-6 2008, 6-1/8 x 9-1/4, 640 pp. Suggested Price: $189.95 / £106.00

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For more information and a complete list

Handbook of Transcription Factor NF-kappaB Edited by

A Practical Handbook Edited by

Gary C. Howard

Castro Valley, California, USA

Sankar Ghosh

Matthew R. Kaser

The transcription factor NF-kB plays a critical role in human health and disease by influencing diverse cellular processes, including immunity and cell survival. Such a broad role has led to studies by researchers from a variety of disciplines. The Handbook of Transcription Factor NF-kappaB brings these studies into a single convenient reference designed to inform researchers and students about the basic mechanisms of NF-kB signaling and function. It also presents cutting-edge research on its more specialized roles across different biological systems and diseases. Edited by a pioneer in the field, it features authoritative contributions from top researchers worldwide.

Written for professionals in the fields of biomedical research, Making and Using Antibodies: A Practical Handbook uses a cookbook approach to presenting methods for the production, characterization, and use of antibodies. The book focuses on specific aspects of antibodies and takes readers on a step-by-step process from antigen preparation to immunizations, adjuvants, screening, purification, storage, and applications. Introductory material accompanies each chapter, giving readers a better understanding of the methods and applications. It covers basic techniques including enzyme-linked immunosorbent assay (ELISA), Western blotting, immunohistochemistry, and flow cytometry.

Catalog no. 2794, ISBN: 978-0-8493-2794-0 2007, 6-1/8 x 9-1/4, 232 pp. Suggested Price: $144.95 / £79.99

Catalog no. 3528, ISBN: 978-0-8493-3528-0 2007, 6-1/8 x 9-1/4, 408 pp., Soft Cover Suggested Price: $154.95 / £86.00

Yale University, New Haven, Connecticut, USA

Immunology 12

Making and Using Antibodies

Illustrated Dictionary of Immunology Third Edition

Julius M. Cruse and Robert E. Lewis

Bell & Associates, San Francisco, California, USA

Nucleic Acids in Innate Immunity Edited by

University of Mississippi Medical Center, Jackson, USA

Ken J. Ishii and Shizuo Akira

Designed for both immunologists and those from other fields seeking an accessible and informative resource in immunology, this substantially revised and expanded edition of the best-selling Illustrated Dictionary of Immunology adds nearly 300 pages to strengthen its position as the leading general reference on the essential concepts of immunology. Written by two of the most respected scientists in the field, this edition features a huge number of illustrations, while also adding additional computer-generated figures and illustrations that illustrate critical aspects of immunology. The third edition also includes terms from various subspecialties, ranging from molecular immunology to transplantation.

Providing insight into new areas of immunology, this book explains the roles of nucleic acids in immunity, describing the mechanism of discrimination based on pattern-recognition receptors (PRRs). It discusses how these PRRs recognize and respond to pathogenassociated molecular patterns (PAMPs) by activating specific signaling pathways. The book focuses on the therapeutic applications of immunomodulatory DNA to prevent or treat infectious diseases, allergic disorders, and cancer, and addresses how the immune system discriminates self and non-self RNA. It also explains what elements within DNA or RNA activate the innate immune recognition of nucleic acids and describes the resulting immune modulation.

Catalog no. 7987, ISBN: 978-0-8493-7987-1 February 2009, 8-1/2 x 11, 992 pp. Suggested Price: $99.95 / £60.99

Catalog no. 68253, ISBN: 978-1-4200-6825-2 2008, 6-1/8 x 9-1/4, 304 pp. Suggested Price: $159.95 / £89.00

Osaka University, Japan

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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A Practical Handbook for Toxicologists and Biomedical Researchers, Second Edition

Animal Models of Diabetes Frontiers in Research, Second Edition Edited by

G.O. Evans

Eleazar Shafrir

Assembling information widely dispersed throughout the literature, the second edition of this work focuses on information of relevance to experimental toxicology as separate from human medicine. It presents background information on the selection and application of biochemical tests in safety assessment studies. In addition to chapters which discuss the assessment of toxicity in specific organs, such as the liver, kidney and thyroid, the book also covers pre-analytical variables, regulatory requirements, and statistical approaches, while highlighting some of the major differences between humans and various laboratory animals.

This new edition of Animal Models of Diabetes provides researchers with updated and expanded information regarding the use of models in experiments with both Type 1 and Type 2 diabetes. It compiles relevant timesaving information on most, if not all, current wellrecognized models for both types of diabetes, including various mice, rats, minipigs and Rhesus monkeys, and provides extensive references for more in-depth study. Among several other topics, it discusses nutritionally diabetes-prone animals, and considerations of insulin resistance and obesity. It also addresses the importance of recent findings on pathogenesis of diabetes and its complications in relation to human disease.

Wellcome Research Laboratories (Retired), UK

Catalog no. 80113, ISBN: 978-1-4200-8011-7 April 2009, 6-1/8 x 9-1/4, 352 pp. Suggested Price: $79.95 / £48.99

Hadassah University Hospital, Jerusalem, Israel

Also Available in Soft Cover

Catalog no. 9534, ISBN: 978-0-8493-9534-5 2007, 6-1/8 x 9-1/4, 384 pp. Suggested Price: $189.95 / £109.00

Animal Hematotoxicology

Biodefense

A Practical Guide for Toxicologists and Biomedical Researchers

Research Methodology and Animal Models Edited by

G.O. Evans

James R. Swearengen

Wellcome Research Laboratories (Retired), UK

USAMRIID, Fort Detrick, Maryland, USA

Hematology data from in vivo toxicology studies remains one of the most predictive measures for human risk, as the same measurements made in pre-clinical toxicology studies can be made in early clinical trials. Covering the three main blood cell types, this work is designed to clarify topics for new entrants in laboratory animal hematology and toxicology. An entire chapter is devoted to immunotoxicology. The text also addresses pre-analytical and analytical variables, as these tend to be more difficult to control in animal studies. Information has been collated from published papers, textbooks and unpublished data. Key references are provided to encourage further study.

To ensure that efforts to improve our biodefensive capabilities continue in an efficient manner, this volume presents a thorough review of pertinent research, encouraging researchers to leverage relevant results, rather than duplicate them. Thus, scientists will be able to make the best use of resources and avoid unnecessary experimentation. With contributions from those who have developed the animal models presented, this book examines bacterial, viral, and toxic agents considered to pose the greatest threat. Each section on a specific agent provides background, followed by a description of those animal models employed, and a discussion of how the findings translate to human impact.

Catalog no. 80091, ISBN: 978-1-4200-8009-4 January 2009, 6-1/8 x 9-1/4, 224 pp. Suggested Price: $79.95 / £44.99

Lab Animal Science

Animal Clinical Chemistry

Catalog no. 2836, ISBN: 978-0-8493-2836-7 2006, 6-1/8 x 9-1/4, 352 pp. Suggested Price: $164.95 / £92.00

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For more information and a complete list Chemoarchitectonic Atlas of the Developing Mouse Brain David M. Jacobowitz

Laboratory of Clinical Science, NIH, Bethesda, Maryland, USA

Louise C. Abbott

Lab Animal Science

Texas A & M University, College Station, USA

With more than 500 color coronal sections, Chemoarchitectonic Atlas of the Developing Mouse Brain provides complete spatial and temporal coverage of the developing brain. Both posterior and anterior regions of the brain are included, and for each of the coronal sections, sagittal sections are provided. This allows for orientation of each coronal section with reference to the whole brain. The temporal coverage includes four gestational ages plus the newborn stage, representing the full period during which neuronal differentiation occurs in the brain. This gives researchers an accurate look at brain structures over the entire range of important stages and regions of brain development. Catalog no. 2667, ISBN: 978-0-8493-2667-7 1998, 8-1/2 x 11, 304 pp. Suggested Price: $389.95 / £217.00

Experimental Surgical Models in the Laboratory Rat Edited by

Alfredo Rigalli and Veronica Di Loreto

Rosario National University, Argentina

The design of an adequate surgical model, like the choice of the animal model itself, is extremely important for obtaining reliable valuable data. Written for biomedical researchers, this manual on the surgery of the rat summarizes a series of techniques that have been applied at the Bone Biology Laboratories of the Medical Science University of Rosario. Stopping short of an exhaustive analysis of the techniques, the manual describes the basis of each surgical technique, the necessary materials, the precautions to consider, the methodology to apply, and the possible results to be obtained. The descriptions of each technique appear with diagrams and pictures. Catalog no. 93266, ISBN: 978-1-4200-9326-1 May 2009, 7 x 10, 224 pp. Suggested Price: $149.95 / £89.00

Handbook of Laboratory Animal Science Second Edition: Volumes I, II, and III Edited by

Jann Hau

University of Copenhagen & Rigshhospitalet, Denmark

Gerald L. Van Hoosier, Jr. University of Washington, Seattle, USA

Now in its second edition, these three volumes offer contributions from eminent scientists who share knowledge gained through their own hands-on research. Taken as a whole, it provides a thorough overview on the use of the laboratory animal for veterinary and biomedical research. However, its in-depth chapters can also serve as stand-alone reference material for addressing specific concerns. Essential Principles and Practices, Volume I provides detailed information about laboratory animal genetics, diseases, health monitoring, nutrition, and environmental impact on animal experiments. It covers procedures in genetic engineering, surgical techniques, the treatment of pain and suffering in laboratory animals, and alternatives to animal experimentation, such as the use of isolated organs, cell cultures, and computer simulations. Animal Models, Volume II details criteria used to choose species and strains. It addresses the development and application of models for research in skeletal disease, xenotransplantation, dental disorders, and psychological testing. It also covers spontaneous genetic mutants and genetically modified animal models. Animal Models, Volume III covers the use of laboratory animals as models in a range of biomedical research disciplines. Individual chapters focus on AIDS, biodefense, and human behavior. Volume I, Catalog no. 1086, ISBN: 978-0-8493-1086-7 2003, 7 x 10, 568 pp. Suggested Price: $154.95 / £86.00 Volume II, Catalog no. 1084, ISBN: 978-0-8493-1084-3 2002, 7 x 10, 280 pp. Suggested Price: $114.95 / £63.99 Volume III, Catalog no. 1893, ISBN: 978-0-8493-1893-1 2005, 7 x 10, 320 pp. Suggested Price: $114.95 / £63.99

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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A Comparative Analysis Matthew Kaufman

University of Edinburgh, Scotland (Retired)

Alexander Yu. Nikitin

Infectious Diseases and Pathology of Reptiles Color Atlas and Text

Cornell University, Ithaca, New York, USA

Edited by

John P. Sundberg

Elliott Jacobson

The Jackson Laboratory, Bar Harbor, Maine, USA Series: Research Methods For Mutant Mice

University of Florida College of Veterinary Medicine, Gainesville, USA

More than 3,000 mutant mice strains have been created through genetic manipulation, and while many molecular techniques are straightforward, analysis of anatomic changes can be a challenge for even the best pathologist. To keep up with current interest in the endocrine system, this volume provides researchers with both a survey and a guide concerning use of the mutant mouse in histological studies of various glands. Applying color throughout, this atlas illustrates the similarities and differences between the mouse endocrine system and that of other species, including humans. It contains approximately 50 high magnification color plates and a variety of sectioned embryos post conception.

Featuring 1,200 high-quality, color photos of normal anatomy and histology, as well as gross, light, and electron microscopic images of pathogens and diseases, this atlas provides definitive information on every known infectious disease affecting reptiles. Beginning with a review of reptile biology, anatomy, and histology, leading authorities then address specific topics such as immunology, circulating inflammatory cells, necropsy techniques, pathogen identification and isolation, molecular diagnosis, and serodiagnostics. The atlas also catalogs specific pathologies due to viruses, bacteria, fungi, and parasites and includes never-before published electron microscope findings of reptile lesions.

Catalog no. 88181, ISBN: 978-1-4200-8818-2 June 2009, 7 x 10, 320 pp. Suggested Price: $149.95 / £89.00

Catalog no. 2321, ISBN: 978-0-8493-2321-8 2007, 8-1/2 x 11, 736 pp. Suggested Price: $199.95 / £117.00

Lab Animal Science

Histologic Basis of Mouse Endocrine System Development

The IACUC Handbook Second Edition Edited by

Jerald Silverman

University of Massachusetts Medical School, Worcester, USA

Mark A. Suckow

University of Notre Dame, Indiana, USA

Managing the Laboratory Animal Facility

Second Edition Jerald Silverman

Sreekant Murthy

University of Massachusetts Medical School, Worcester, USA

Since its establishment by USDA regulation in the 1980s, the Institutional Animal Care and Use Committee has evolved as the premiere instrument of animal welfare supervision for institutions in the United States. The IACUC Handbook provides a foundation for those attempting to understand and implement the various responsibilities of this committee. This new edition features comprehensive updates for all pertinent federal laws, regulations, and policies. It incorporates revised suggestions from experienced professionals in the field to guide IACUC members on best-practice compliance. With concise, easy-to-find information, it remains the reference of choice for researchers and professionals.

A launching pad to providing high-quality management of laboratory animal facilities in a financially sound manner, Managing the Laboratory Animal Facility provides a basic understanding of management and leadership concepts in laboratory animal science. While retaining the focus of its predecessor, this new edition contains over 100 more pages of new and expanded material. It includes an entirely new chapter on leadership, a greatly expanded chapter on the management of human resources, a new appendix on productivity goals and measurements, and a revised appendix on how to calculate per diem rates.

Drexel University, Philadelphia, Pennsylvania, USA

Catalog no. 4010, ISBN: 978-0-8493-4010-9 2007, 7 x 10, 652 pp. Suggested Price: $89.95 / £51.99

Catalog no. 55569, ISBN: 978-1-4200-5556-6 January 2009, 6-1/8 x 9-1/4, 328 pp. Suggested Price: $79.95 / £44.99

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For more information and a complete list

The Laboratory Animal Pocket Reference Series - Ten Volume Set Edited by

Mark A. Suckow, University of Notre Dame, Indiana, USA

Lab Animal Science

The Laboratory Animal Pocket Reference Series was created to assist those who work with laboratory animals, enabling them to provide the most humane, responsible care possible. These bestselling books are compact and lay flat when opened, making them perfect for bench-top use. Each one includes important husbandry, care, veterinarian, and management information with regard to the titled species along with experimental methodology and resources.

Garrett Field

Eli Lilly and Company, Indianapolis, Indiana, United States

Todd A. Jackson

Bristol-Myers Squibb, Evansville, Indiana, USA

Catalog no. 2893, ISBN: 978-0-8493-2893-0 2007, 6-1/8 x 9-1/4, 184 pp., Soft Cover Suggested Price: $52.95 / £29.99

The Laboratory Mouse Mark A. Suckow

Save on the set!

University of Notre Dame, Indiana, USA

Catalog no. 2560, ISBN: 978-0-8493-2560-1 2000, 8-1/2 x 11 Suggested Price: $470.00 / £261.00

The Jackson Laboratory, Bar Harbor, Maine, USA

The Laboratory Cat Brent J. Martin

Medical College of Ohio

Catalog no. 2567, ISBN: 978-0-8493-2567-0 1998, 6-1/8 x 9-1/4, 160 pp., Soft Cover Suggested Price: $52.95 / £29.99

The Laboratory Guinea Pig Lizabeth A. Terril-Robb

Purdue University, West Lafayette, Indiana, USA

Donna J. Clemons Sun Prairie, USA

The Laboratory Canine

Catalog no. 2564, ISBN: 978-0-8493-2564-9 1998, 6-1/8 x 9-1/4, 192 pp., Soft Cover Suggested Price: $52.95 / £29.99

The Laboratory Hamster and Gerbil Karl J. Field

Bristol Myers Veterinary Sciences, Flemington, New Jersey, USA

Amber L. Sibold

Consultant, East Hanover, New Jersey, USA

Catalog no. 2566, ISBN: 978-0-8493-2566-3 1999, 6-1/8 x 9-1/4, 168 pp., Soft Cover Suggested Price: $52.95 / £29.99

The Laboratory Swine Peter J. A. Bollen

University of Southern Denmark

Axel Kornerup Hansen

Agriculture University, Frederiksberg, Denmark

Helle J. Rasmussen

Odense University, Odense, Denmark

Catalog no. 1035, ISBN: 978-0-8493-1035-5 2000, 6-1/8 x 9-1/4, 152 pp., Soft Cover Suggested Price: $52.95 / £29.99

Peggy Danneman Cory Brayton

John Hopkins University School of Medicine, Baltimore, Maryland, USA

Catalog no. 0322, ISBN: 978-0-8493-0322-7 2001, 6-1/8 x 9-1/4, 184 pp., Soft Cover Suggested Price: $52.95 / £29.99

The Laboratory Rat Patrick E. Sharp

National University of Singapore

Marie C. LaRegina

Washington University, St. Louis, Missouri, USA

Catalog no. 2565, ISBN: 978-0-8493-2565-6 1998, 6-1/8 x 9-1/4, 240 pp., Soft Cover Suggested Price: $52.95 / £29.99

The Laboratory Rabbit Mark A. Suckow

University of Notre Dame, Indiana, USA

Fred A. Douglas

Purdue University, West Lafayette, Indiana, USA

Catalog no. 2561, ISBN: 978-0-8493-2561-8 1997, 6-1/8 x 9-1/4, 160 pp., Soft Cover Suggested Price: $52.95 / £29.99

The Laboratory Small Ruminant Matthew J. Allen

SUNY Health Science Center, Syracuse, New York, USA

Gary L. Borkowski

Consultant, Saint Louis, Missouri, USA

Catalog no. 2568, ISBN: 978-0-8493-2568-7 1999, 6-1/8 x 9-1/4, 176 pp., Soft Cover Suggested Price: $52.95 / £29.99

The Laboratory Nonhuman Primate Jeffrey D. Fortman, Terry A. Hewett, and B. Taylor Bennett University of Illinois, Chicago, Illinois, USA

Catalog no. 2562, ISBN: 978-0-8493-2562-5 2002, 6-1/8 x 9-1/4, 288 pp., Soft Cover Suggested Price: $57.95 / £31.99

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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Surgery, Anesthesia, Imaging, and Experimental Techniques, Second Edition Edited by

Advanced Quantitative Microbiology for Foods and Biosystems Models for Predicting Growth and Inactivation Micha Peleg

M. Michael Swindle

Medical University of South Carolina, Charleston, USA

To diminish the learning curve associated with using swine as models, this book provides practical technical information for the use of swine in biomedical research. It focuses on models produced by surgical and other invasive procedures, supplying the basic principles for performing experiments with an organ or system of interest. This edition contains never-before-published images, new chapters on toxicology and radiobiology, updated sections on anesthesia and perioperative care, and expanded details on anatomy and endoscopy. It also includes an accompanying DVD with 3-D color images. Catalog no. 9278, ISBN: 978-0-8493-9278-8 2007, 7 x 10, 496 pp. Suggested Price: $154.95 / £86.00

University of Massachusetts, Amherst, USA Series: Contemporary Food Science, 18

Presenting a novel view of the quantitative modeling of microbial growth and inactivation patterns in food, water and biosystems, this book describes new models to predict microbial growth and survival under a variety of conditions. The author provides coverage of both traditional and alternative models of thermal and non-thermal inactivation. Included are chapters on microbial dose response, interpretation of irregular count records, and estimating the frequencies of future outbursts. Featuring numerous illustrations, this volume is a valuable reference tool for food and water microbiologists, food technologists and engineers, government officials, public health specialists. Catalog no. 3645, ISBN: 978-0-8493-3645-4 2006, 6 x 9, 456 pp. Suggested Price: $175.95 / £98.00

Lab Animal Science / Microbiology

Swine in the Laboratory

Antimicrobial Susceptibility Testing Protocols Textbook

Edited by

Veterinary Clinical Epidemiology

Richard Schwalbe

Third Edition

Christiana Care Health Services, Wilmington, Delaware, USA

Ronald D. Smith

Avery C. Goodwin

University of Illinois College of Veterinary Medicine, Urbana-Champaign, USA

Veterinary Clinical Epidemiology, Third Edition serves as both a teaching resource and a reference on the application of epidemiologic methods in veterinary clinical research. The new edition of this successful book continues its focus on observations of naturally or spontaneously occurring diseases. This well-illustrated text includes discussion of applications of epidemiology in medical decision making at the individual and herd levels; details the relevance of epidemiology to companion animal, food animal, and population medicine; and describes applications of molecular diagnostic tools and advanced statistical techniques. It includes many case studies and examples from veterinary literature. Catalog no. 1566, ISBN: 978-0-8493-1566-4 2006, 7 x 10, 280 pp. Suggested Price: $109.95 / £57.99

University of Maryland Hospital, Baltimore, USA

Lynn Steele-Moore

FDA/CDER/OND/OAP, Silver Spring, Maryland, USA

The reported increase in the occurrence of antibiotic-resistant bacteria emphasizes the importance of accurate susceptibility testing. This timely guide examines the role of the clinical microbiology lab in integrated patient care. The first section addresses basic susceptibility disciplines such as macro and microbroth dilution, agar dilution, and disk diffusion. The second part considers specialized susceptibility protocols that may be performed by a subset of labs. Finally, the book covers antibiotic development and discusses antibiogram design and use. It includes extensive references and a table of antibiotic classes and common bug-drug susceptibilities. Catalog no. DK2238, ISBN: 978-0-8247-4100-6 2007, 7 x 10, 432 pp. Suggested Price: $154.95 / £86.00

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For more information and a complete list

Bacterial Resistance to Antimicrobials Second Edition Edited by

Richard G. Wax, Kim Lewis, Abigail Salyers, and Harry Taber

Cryptosporidium and Cryptosporidiosis Second Edition Edited by

Ronald Fayer

United States Department of Agriculture

Lihua Xiao

National Center for Disease Control & Prevention, Atlanta, USA

Microbiology

Blending scientific and practical approaches, this second edition examines the social, economic, and medical issues related to the growing problem of bacterial resistance. It outlines the forces that contributed to the abuse of antibiotics and led to the current crisis. The core chapters describe the latest findings bacterial ecology, the biomechanics of resistance and susceptibility, and the latest avenues to develop new antibiotics that are resistant to resistance mechanisms. Examining the success and limitations of complimentary approaches, the book pulls together all of the information on resistance mechanisms in different groups of bacteria to help future efforts develop effective combinations.

This latest edition of a bestseller covers every aspect of these adaptable parasites, including molecular biology, genetic regulation, and comparative genomics. It highlights practical considerations such as outbreaks, transmission dynamics; disinfection, and disease presentation in reptiles, birds, and mammals. It also discusses the treatment of drinking water and wastewater, details governmental regulations, examines host immune responses, and explores the use of structural proteins and metabolic pathways as potential drug targets. The final chapters define appropriate animal models for parasite propagation and research and describe the cells and media most useful for in vitro techniques.

Catalog no. 9190, ISBN: 978-0-8493-9190-3 2008, 6-1/8 x 9-1/4, 448 pp. Suggested Price: $185.95 / £103.00

Catalog no. 52268, ISBN: 978-1-4200-5226-8 2008, 7 x 10, 576 pp. Suggested Price: $129.95 / £74.99

Defensive Mutualism in Microbial Symbiosis 18

Cleanroom Microbiology for the Non-Microbiologist Second Edition

Edited by

James F. White

Rutgers University, New Brunswick, New Jersey, USA

Monica S. Torres

David M. Carlberg

Univ Nacional de Mar del Plata, Balcarce, Argentina

Huntington Beach, California, USA

Series: Mycology, 27

This new edition of a bestseller explains the consequences of microbiological contamination, what contamination is all about, how microorganisms grow, and how they can be controlled. The book introduces the types, sources, control, and elimination of organisms encountered in the manufacture of sterile products as well as the applications for bacterial detection, avoidance of contamination, and cleanroom design considerations. The author has rewritten the text according to new standards and practices for controlling microbial contamination in cleanrooms. Catalog no. PH1996, ISBN: 978-0-8493-1996-9 2005, 6-1/8 x 9-1/4, 216 pp. Suggested Price: $175.95 / £98.00

Although there is a general scientific consensus that endosymbionts represent a new frontier for drug discovery, this book is the first to explore that possibility. It also takes the novel approach of expanding the concept of defensive mutualisms to evaluate defense against environmental abiotic and biotic stresses. In addressing the topic of defensive mutualisms in microbial symbiosis across this wide spectrum, it includes chapters on defensive mutualistic associations involving multiple kingdoms of organisms in terrestrial and aquatic ecosystems – plant, animal, fungi, bacteria, and protozoans. Authors for the various chapters represent the world authorities in each field. Catalog no. 69314, ISBN: 978-1-4200-6931-0 May 2009, 7 x 10, 464 pp. Suggested Price: $129.95 / £78.99

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

Disinfection and Decontamination

Principles, Applications and Related Issues Edited by

Textbook

Fundamental Food Microbiology Fourth Edition Bibek Ray

University of Wyoming (Emeritus), Laramie, USA

Gurusamy Manivannan

Arun Bhunia

Taking a unique multidisciplinary approach, this book provides an overview of available antimicrobial and anti-infective materials used in different industries to prevent infection. It also examines the infection challenges faced with the use of medical devices as well as within hospital environments. Including extensive references, this text highlights the best current research practices and principles, and offers detailed insight into the issues associated with testing methods and strategies. It includes diverse applications in the pharmaceutical, personal care, medical devices and other related industries.

Maintaining the high standard set by the previous best-selling editions, this fourth edition continues to present the most upto-date information in this rapidly growing and highly dynamic field. Revised and expanded to reflect recent advances, it includes many new and emerging pathogens as well as descriptions of the mechanism of pathogenesis. An entirely new chapter on detection methods appears in this edition with evaluations of advanced rapid detection techniques using biosensors and nanotechnology. Along with many more easy-to-follow figures and illustrations, each chapter includes an introduction, conclusion, references, and questions.

Catalog no. 9074, ISBN: 978-0-8493-9074-6 2008, 6-1/8 x 9-1/4, 512 pp. Suggested Price: $144.95 / £79.99

Fermentation Microbiology and Biotechnology

Purdue University, West Lafayette, Indiana, USA

Catalog no. 7529, ISBN: 978-0-8493-7529-3 2008, 7 x 10, 536 pp. Suggested Price: $69.95 / £40.99

Second Edition

Fundamentals of Biofilm Research

Edited by

Zbigniew Lewandowski

E.M.T. El-Mansi, C.F.A. Bryce, A.L. Demain, and A.R. Allman

Montana State University, Bozeman, USA

Infors UK Ltd., Makerfield, UK

Washington State University, Pullman, USA

Retaining valuable information from the first edition, including fermentation kinetics and flux control analysis, this edition addresses numerous topics that have risen to importance. Updated chapters explore the production of primary and secondary metabolites such as amino acids, nucleotides, and vitamins, as well as antibiotics, immunosuppressants, and anti-tumor agents. The book examines advances in enzyme and co-factor engineering, cell immobilization, and sensor technology. Packed with examples and industry case studies, the text is accessible to academic and industry researchers, as well as students in applied microbiology, and pharmaceutical biotechnology.

Fundamentals of Biofilm Research discusses compatible tools and measurements that can be used to conduct biofilm studies and interpret their results in a consistent manner. The authors introduce conceptual, physical, computational, and virtual tools to help achieve reproducible results, align research specific parameters, and ease difficulties in communication. They reconcile the inability of computational methods to account for conceptual variables with the use of the stratified biofilm model. In addition to the wealth of information provided in the book, the authors also include a CD with several software packages to aid in biofilm research.

Catalog no. 5334, ISBN: 978-0-8493-5334-5 2007, 7 x 10, 576 pp. Suggested Price: $97.95 / £54.99

Catalog no. 3541, ISBN: 978-0-8493-3541-9 2007, 7 x 10, 480 pp. Suggested Price: $134.95 / £74.99

Also Available in Soft Cover

Microbiology

Steris Corporation, St. Louis, Missouri, USA

Haluk Beyenal

Rest of the World Tel: +44 (0) 1235 400 524 • Fax: +44 (0) 1235 400 525 e-mail: (UK) uk.trade@tandf.co.uk • (International) international@tandf.co.uk

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For more information and a complete list Fungal Pathogenesis in Plants and Crops

Molecular Biology and Host Defense Mechanisms, Second Edition P. Vidhyasekaran

Tamil Nadu Agric. University, Coimbatore, India Series: Books in Soils, Plants, and the Environment, 58

Microbiology

Completely updated and revised, this second edition of the widely acclaimed Fungal Pathogenesis in Plants and Crops covers the fungal infection process, molecular host-defense mechanisms, and events leading to the suppression of these defense mechanisms by fungal pathogens. This edition features three brand new chapters on disease resistance and susceptibility genes in signal perception and emission, and cell death signaling in disease susceptibility and resistance. This text also includes additional material on phytoalexins, toxins, signal perception and transduction in fungal pathogenesis, and 17 families of pathogenesis-related proteins. Catalog no. DK9867, ISBN: 978-0-8493-9867-4 2008, 7 x 10, 536 pp. Suggested Price: $175.95 / £98.00

Fungi

Multifaceted Microbes 20

Edited by

Geomicrobiology Fifth Edition

Henry Lutz Ehrlich

Rensselaer Polytechnic Institute, Troy, New York, USA

Dianne K. Newman

Massachusetts Institute of Technology and Howard Hughes Medical Institute, Cambridge, USA

Reflecting important new discoveries and advances in the field, this fifth edition presents a survey of various aspects of geomicrobiology, including the microbial role in the formation and degradation of minerals and fossil fuels and elemental cycling. It explores the role of microbes in early evolution, as well as in the lithosphere, deep subsurface, and hydrosphere. This edition includes more foundational information, covering important principles and methods for identification and function of specific microbes in a particular process. Generously laden with tables, graphics, diagrams, and photographs, the remainder of the book examines the geomicrobial aspects of a wide range of minerals. Catalog no. 7906, ISBN: 978-0-8493-7906-2 January 2009, 7 x 10, 628 pp. Suggested Price: $199.95 / £111.00

Guide to Microbiological Control in Pharmaceuticals and Medical Devices Second Edition

B.N. Ganguli

Agharkar Research Institute, Pune, Maharashtra, India

S.K. Deshmukh

Edited by

Stephen P. Denyer Cardiff University, UK

Nicholas Piramal Research Centre, Mumbai, India

Rosamund M. Baird

Offering a uniquely extensive scope of coverage, Fungi: Multifaceted Microbes delves into a wide range of topics in fungal biochemistry and biotechnology. These include classical and molecular taxonomy, as well as evolutionary aspects. It addresses fungi applications in environmental control, metabolites from marine fungi, endophytic and endolythic fungi, aquatic mycology, and lichens. It also provides a chapter on the new area of fungi in nanoparticle synthesis. Written by internationally recognized experts, this book offers a highly authoritative survey of the literature that will prove useful to academic professionals across many fields, as well as both aspiring and established industrial researchers.

This second edition covers those principal aspects of microbiology that are relevant to the preformulation, formulation, manufacturing and license application stages of the production of pharmaceuticals, while expanding the book’s focus to include medical devices. Covering good manufacturing practice in the control of contamination, the text explores monitoring microbiological quality, the preservation of pharmaceutical formulations and principles of sterilization, including microbiological specific considerations for biotechnological products and other medical devices. It also provides additional materials on package integrity testing, and the evaluation of contamination risks in clean rooms.

Catalog no. 43285, ISBN: 978-1-4200-4328-0 2007, 7 3/8 x 9 1/4, 321 pp. Suggested Price: $154.95 / £86.00

Catalog no. TF2048, ISBN: 978-0-7484-0615-9 2007, 6-1/8 x 9-1/4, 504 pp. Suggested Price: $164.95 / £92.00

University of Bath, UK

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

Handbook of Food Spoilage Yeasts Second Edition

Handbook of Listeria monocytogenes Edited by

University of Horticulture, Budapest, Hungary

Dongyou Liu

Series: Contemporary Food Science, 6

Human Genetic Signatures, North Ryde, NSW, Australia

Including new tables and figures and 20 percent more species, this second edition provides an unparalleled overview of spoilage yeasts, providing coverage of the biodiversity and ecology of yeasts in a wide variety of food types and commodities. The author incorporates new insights in taxonomy and phylogeny, molecular techniques for detection and identification, and information on the physiological and genetic background of yeast stress responses. He introduces alternative methods for the inhibition and inactivation of yeasts, and improved processing, packaging, and storage technologies. An entirely new chapter explores new industrial applications of yeasts in food fermentation and biotechnology.

Listeria monocytogenes has the capacity to survive many food processing procedures. With increased consumption of ready-to-eat products, this bacterium has accounted for a significant increase in human foodborne infections worldwide, subsequently leading to a wave of new research. Written by leading specialists in the field, the Handbook of Listeria monocytogenes provides an expert summary on the biology, virulence mechanisms, identification techniques, and recent research and development trends related to L. monocytogenes. This comprehensive reference offers complete coverage of pathgenicity, identification, detection, genomics, proteomics, immunity, and vaccine strategies.

Catalog no. 44931, ISBN: 978-1-4200-4493-5 2008, 7 x 10, 352 pp. Suggested Price: $154.95 / £86.00

Catalog no. 51407, ISBN: 978-1-4200-5140-7 2008, 7 x 10, 552 pp. Suggested Price: $169.95 / £94.00

Handbook of Helminthiasis for Public Health D.W.T. Crompton

University of Glasgow, Scotland

Handbook of Media for Clinical Microbiology

Microbiology

Tibor Deák

Second Edition

Lorenzo Savioli

Control of Neglected Tropical Diseases, Geneva, Switzerland

Ronald M. Atlas and James W. Snyder

Written by internationally respected experts, Handbook of Helminthiasis for Public Health provides information essential in the development of an integrated approach to the prevention, control and treatment of disease caused by endoparasitic helminths. The text is divided into sections dealing with the main groups of helminth infections and the diseases they induce. Each section addresses diagnostic techniques, epidemiology/distribution, pathogenesis, morbidity/pathology, treatment, prevention, and control. Emphasis is placed on methods for reducing morbidity, interrupting and reducing transmission, and techniques to prevent infection.

Handbook of Media for Clinical Microbiology, Second Edition provides an easy-to-use reference for routine and specialized media employed in the cultivation of pathogenic bacteria, fungi, and viruses in clinical diagnostic laboratories. This edition adds descriptions of newly employed media used for cultivating emerging pathogens. It also discusses the role of the clinical laboratory in the diagnosis of infectious diseases and the process for detecting infectious diseases, including specimen receipt, media selection, antibiotic susceptibility testing, and biosafety considerations. It also covers the clinical laboratory’s role within the Laboratory Response Network for detecting bioterrorism.

Catalog no. 3328, ISBN: 978-0-8493-3328-6 2007, 6-1/8 x 9-1/4, 362 pp. Suggested Price: $154.95 / £86.00

University of Louisville, Kentucky, USA

Catalog no. 3795, ISBN: 978-0-8493-3795-6 2006, 7 x 10, 544 pp. Suggested Price: $164.95 / £92.00

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For more information and a complete list

Handbook of Media for Environmental Microbiology Second Edition Ronald M. Atlas

University of Louisville, Kentucky, USA

Microbiology

The second edition of a bestseller, this book provides a comprehensive reference for the cultivation of bacteria, archaea, and fungi from diverse environments, including extreme habitats. Expanded to include 2,000 media formulations, this book compiles the descriptions of media of relevance for the cultivation of microorganisms from soil, water, and air. The format allows easy reference to the information needed to prepare media for the cultivation of microorganisms required for environmental analysis, including the determination of water safety. The media are organized alphabetically, and each listing includes medium composition, instructions for preparation, commercial sources, and uses. Catalog no. 3560, ISBN: 978-0-8493-3560-0 2005, 7 x 10, 672 pp. Suggested Price: $175.95 / £98.00

Handbook of Microbiological Media for the Examination of Food Second Edition Ronald M. Atlas

University of Louisville, Kentucky, USA

To meet society’s increasing emphasis on food safety during production and storage, this handbook provides indepth descriptions of a tremendous range of media used for the cultivation of potential foodborne pathogens and food-spoilage microorganisms. This new edition includes FDA recommendations and features newly developed media used to diagnose recently emerging foodborne diseases. In consideration of the new FDA Hazard Analysis and Critical Control Point directive, the Handbook of Microbiological Media for the Examination of Food, Second Edition also provides an appendix with charts illustrating the appropriate required analyses for the microexamination of foods. Catalog no. 3561, ISBN: 978-0-8493-3561-7 2006, 7 x 10, 464 pp. Suggested Price: $164.95 / £92.00

Insect Symbiosis Volume 3 Edited by

Kostas Bourtzis

University of Ioannina, Agrinio, Greece

Thomas A. Miller

University of California, Riverside, USA

Handbook of Microbiological Media Third Edition Ronald M. Atlas

University of Louisville, Kentucky, USA

This third edition of the best-selling Handbook of Microbiological Media carries on the tradition of CRC handbook excellence. This updated edition lists the formulation, method of preparation, and uses for over 4,000 microbiological media. With 30 percent more entries than the previous edition, the book includes recent information on international collection of microorganisms and expanded information of yeast, algae, and archaea. The book also contains formulations and uses of media for isolation, culture, identification, and maintenance of microorganisms. The entries are arranged alphabetically by medium name and includes synonyms, sources, trademarks, and more. Catalog no. 1818, ISBN: 978-0-8493-1818-4 2004, 7 x 10, 2056 pp. Suggested Price: $219.95 / £128.00

Like its predecessors in the set, Insect Symbiosis, Volume 3 illustrates the important ramifications symbiosis research has for evolutionary biology, microbiology, parasitology, physiology, genetics, and animal behavior. It is especially relevant to the control of agricultural and disease-carrying pests worldwide. This text includes pioneering chapters on paratransgenesis in termites, bacterial symbionts in Anopheles spp. and other mosquito vectors, endosymbionts of lice, and the structure and function of the bacterial community associated with the Mediterranean fruit fly. These studies suggest practical applications in pest control involving novel, pesticidefree, biologically-controlled approaches. Volume III, Catalog no. 6410X, ISBN: 978-1-4200-6410-0 January 2009, 7 x 10, 384 pp. Suggested Price: $119.95 / £66.99 Volume I, Catalog no. 1286, ISBN: 978-0-8493-1286-1 2003, 7 x 10, 368 pp. Suggested Price: $129.95 / £74.99 Volume II, Catalog no. 4194, ISBN: 978-0-8493-4194-6 2006, 7 x 10, 304 pp. Suggested Price: $129.95 / £74.99

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Listeria, Listeriosis, and Food Safety Laboratory Biosecurity Handbook Reynolds M. Salerno and Jennifer Gaudioso

Third Edition Edited by

Elliot T. Ryser

Michigan State University, East Lansing, USA

Elmer H. Marth

University of Wisconsin, Madison, USA Series: Food Science and Technology, 92

In recognition of the vital need to protect legitimate facilities from the theft and misuse of dangerous pathogens and toxins, the Laboratory Biosecurity Handbook serves as a guide to the implementation of pathogen protection programs. The first sections offer an historical overview of biological weapons activity, key principles of biosecurity and its integration into existing frameworks, as well as a discussion of biosecurity risk. Later sections discuss biosecurity risk assessments, describe detailed components of a biosecurity program, and offer a graded approach to biosecurity through multiple risk levels. The work also covers risk prioritization of biological assets and biosecurity training.

Completely revised, the latest edition of this bestseller incorporates recent findings to present a complete and current overview of foodborne listeriosis, including information on listeriosis in animals and humans, pathogenesis, methods of detection, and subtyping. Two new chapters deal with risk assessment, cost of outbreaks, regulatory control in various countries, and future directions for research. The text covers many high-risk foods including fermented and unfermented dairy products, meat, poultry, fish, seafood, and products of plant origin. This authoritative resource has proven to be a critical tool for those involved with preventing and curbing outbreaks of this dangerous pathogen.

Catalog no. 6475, ISBN: 978-0-8493-6475-4 2007, 6 x 9, 208 pp. Suggested Price: $104.95 / £57.99

Catalog no. DK3089, ISBN: 978-0-8247-5750-2 2007, 7 x 10, 896 pp. Suggested Price: $195.95 / £109.00

Microbiology

Sandia National Laboratories, Albuquerque, New Mexico, USA

Lactic Acid Bacteria

Microbiological and Functional Aspects, Third Edition

Microbial Food Contamination

Edited by

Seppo Salminen

University of Turku, Finland

Second Edition

Atte von Wright

University of Kuopio, Finland

Edited by

Arthur C. Ouwehand

Health and Nutrition, Danisco Finland

Charles L. Wilson

Series: Food Science and Technology

President & CEO, Wilson Associates International LLC, Shepherdstown, West Virginia, USA

With more than 25 percent new material, this third edition provides an excellent overview of current research on the function, utilization, and nutritional aspects of lactic acid bacteria. The book showcases the scientific, commercial, and technological findings of 37 international contributors that may impact the quality, taste, and dietary value of foods such as milk, cereal, vegetables, and meat. It contains new chapters ranging from topics on mathematical modeling and vegetable fermentation to techniques for the analysis of gut microbiota and probiotics for fish. It also features updated information of future research directions for the utilization of lactic acid bacteria.

Microbial Food Contamination, Second Edition is a comprehensive evaluation of the microbiology, biochemistry, detection, risk, and threat of foodborne illness in today’s global climate. It introduces new insights into the pathogenic effect of contaminants, presents recent advances in detecting and monitoring foodborne human pathogens, and examines control and prevention measures. Contributions discuss globalization and the increased risk for transnational contamination, the impact of food contamination on international trade, and international programs to mitigate these events. Finally, the book explores the risk of bioterrorism and considers a Food Defense Plan that can reduce vulnerability.

Catalog no. DK1291, ISBN: 978-0-8247-5332-0 2005, 7 x 10, 656 pp. Suggested Price: $259.95 / £144.00

Catalog no. 9076, ISBN: 978-0-8493-9076-0 2008, 6-1/8 x 9-1/4, 632 pp. Suggested Price: $164.95 / £92.00

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For more information and a complete list Textbook

Microbial Limit and Bioburden Tests

Validation Approaches and Global Requirements, Second Edition Lucia Clontz

Diosynth Biotechnology, a part of ScheringPlough, Morrisville, North Carolina, USA

Microbiology

Often called the “industry bible,” Microbial Limit and Bioburden Tests: Validation Approaches and Global Requirements provides a practical guide to microbial limit methodologies. This new second edition has been substantially updated and expanded to include the most recent microbial limit tests and bioburden testing mandated by USP-NF. A comprehensive reference source, it reflects current industry standards, regulatory expectations, and the latest technical and scientific information. This edition addresses new topics such as water testing and also includes new chapters that provide complete coverage of biofilms, environmental monitoring, and microbial identification. Catalog no. 53485, ISBN: 978-1-4200-5348-7 January 2009, 6-1/8 x 9-1/4, 280 pp. Suggested Price: $189.95 / £106.00

Modelling Microorganisms in Food Edited by

Stanley Brul

University of Amsterdam and Unilever Food Research Centre, The Netherlands

Suzanne van Gerwen

Unilever Foods Development Europe, The Netherlands

Modern Soil Microbiology Second Edition Edited by

Jan Dirk van Elsas

Groningen University Biological Center, Haren, The Netherlands

Janet K. Jansson

Swedish University of Agricultural Sciences, Uppsala, Sweden

Jack T. Trevors

University of Guelph, Ontario, Canada

In the ten years since the publication of Modern Soil Microbiology, the study of soil microbiology has significantly changed, both in the understanding of the diversity and function of soil microbial communities and in the research methods. Completely revised and rewritten by international experts, this second edition provides broad, cutting-edge knowledge of a discipline that encompasses ecology, physiology, genetics, molecular biology, and biotechnology, and makes use of biochemical and biophysical approaches. The chapters cover topics ranging from the fundamental to the applied, and describe the use of advanced methods that have provided a great thrust to the discipline of soil microbiology. Catalog no. DK3097, ISBN: 978-0-8247-2749-9 2007, 6 x 9, 672 pp. Suggested Price: $119.95 / £35.99

Molecular Detection of Foodborne Pathogens Edited by

Marcel Zwietering

Dongyou Liu

Wageningen University, The Netherlands

Human Genetic Signatures, North Ryde, NSW, Australia

The growing use of minimal processing techniques requires the employment of models exercising greater precision. Edited by leading authorities, this volume reviews current developments in quantitative microbiology. It offers an overview of predictive microbiology and looks at experiment design and tools. While the first section discusses the construction of quantitative models, the second part looks at specific areas regarding new approaches to modelling microbial behavior. Among other topics, it discusses experimental design, uncertainty and variability, and modelling lag time.

With international trade and the world-wide distribution of a variety of food types, new foodborne infections are continuously emerging. Currently, there are more than 250 known foodborne diseases. This comprehensive work catalogs the detection and identification methods for every major foodborne bacterial, fungal, viral, and parasitic pathogen by using state-of-art molecular techniques. Each chapter contains a concise review of the pathogen with respect to its biology, epidemiology, and pathogenesis; a detailed description of current molecular procedures for its detection and identification; and a discussion on further research needs pertaining to improved diagnosis.

Catalog no. WP9149, ISBN: 978-0-8493-9149-1 2007, 6 x 9, 294 pp. Suggested Price: $229.95 / £128.00

Catalog no. 76434, ISBN: 978-1-4200-7643-1 June 2009, 8-1/2 x 11, 776 pp. Suggested Price: $159.95 / £97.00

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Practical Handbook of Microbiology Second Edition Edited by

Comparative Genomics

University of Medicine & Dentistry of New Jersey, USA

Edited by

Lorrence H. Green

Westbury Diagnostics Inc., New York, USA

Glaxo Smith Kline, Collegeville, Pennsylvania, USA

Providing basic knowledge and practical information in a clear and concise single volume, the second edition of the best-selling Practical Handbook of Microbiology provides in-depth chapters on all aspects of the field, from classical microbiology to genomics. Reflecting the recent, sweeping changes in the field, yet retaining the popular format of the original, this second edition includes many updates and more than 20 new or expanded chapters. Various brief taxonomy sections from the first edition have been rewritten as complete chapters with descriptions of genus and species. Several tables have been updated and revised and the book also includes a new survey table of selected eubacteria.

Through comparative analysis, the genomes of a number of species are providing a deeper understanding of the human genome. This is proving to be highly useful in drug research, especially in the treatment of otherwise intractable conditions. Comparative Genomics: Basic and Applied Research compiles first-hand descriptions of the pioneering achievements of prominent researchers from diverse fields. The text focuses on revolutionary advances in DNA-sequencing technology, bold new approaches to the organization and analysis of large phylogenetic data sets, the impact of comparative genomics on our understanding of evolution, and efforts toward developing novel antimicrobial drugs.

Catalog no. 9365, ISBN: 978-0-8493-9365-5 January 2009, 7 x 10, 864 pp. Suggested Price: $159.95 / £89.00

Catalog no. 9216, ISBN: 978-0-8493-9216-0 2008, 6-1/8 x 9-1/4, 400 pp. Suggested Price: $154.95 / £86.00

Thermophiles

Textbook

Edited by

Forensic DNA Analysis

Frank Robb, Garabed Antranikian, Dennis Grogan, and Arnold Driessen

J. Thomas McClintock

Biology and Technology at High Temperatures

James R. Brown

Microbiology / Molecular Biology

Basic and Applied Research

Emanuel Goldman

A Laboratory Manual

University of Groningen, The Netherlands

DNA Diagnostics, Inc., Crofton, Maryland, USA

Much is being learned from thermophiles, especially about biology at the molecular level and the genetic mechanisms that permit adaptation and survival. This text reviews recent literature in the thermophile field written by international experts. It discusses protective strategies based on the resiliency of thermophiles, and also investigates molecular regulatory mechanisms and protein synthesis. By studying this odd organism, its exaggerated response mechanisms, and its development over many short-lived generations, we can learn about diseases linked to improper protein folding, and also more fully understand the ingenious design of DNA, and all that such an understanding implies regarding survival in a changing environment.

This introductory text provides a contextual history and overview of the science and use of DNA typing methods. Logically organized, with clear, concise language, this manual ensures a fundamental understanding of forensic DNA analysis and a thorough background of the molecular techniques used to determine an individual’s identity. The experiments cover DNA extraction, concentration, and assessment; DNA analysis using restriction fragment length polymorphisms; polymerase chain reaction and PCR-based typing tests; short tandem repeat analysis; and mitochondrial DNA analysis. There is also an extensive glossary of DNA typing terminology and basic terms used in molecular biology.

Catalog no. 9214, ISBN: 978-0-8493-9214-6 2008, 7 x 10, 368 pp. Suggested Price: $159.95 / £92.00

Catalog no. 63294, ISBN: 978-1-4200-6329-5 2008, 8-1/2 x 11, 176 pp., Soft Cover Suggested Price: $49.95 / £27.99

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For more information and a complete list

Molecular Biology

Handbook of Nucleic Acid Purification

Medicinal Protein Engineering

Edited by

Dongyou Liu

Yury E. Khudyakov

An all-encompassing volume on nucleic acid purification strategies for bacteria, viruses, fungi, parasites, mammals, and plants, this book emphasizes sample preparation methods for direct molecular applications. Each chapter provides a concise review of historical background and purification principles, a detailed description of current techniques, including several state-of-the-art protocols for large and small scale preparations, and a discussion for future development trends. A comprehensive reliable reference, the book supplies a useful roadmap for clinical, forensic, and research scientists involved in molecular analysis of biological specimens.

Medicinal Protein Engineering provides a comprehensive overview of one of the most complex areas of molecular research. Using a multidisciplinary approach, this book seeks to move readers from experiment and theory to actual applications. In particular, the text focuses on cutting-edge research in protein engineering and medicinal applications of engineered proteins. It discusses computational approaches to protein design and explores the strong connection between protein and genetic engineering. It also considers those medicinal proteins that could be improved through protein engineering, including antibodies, antigens, and a variety of vaccines.

Human Genetic Signatures, North Ryde, NSW, Australia

Catalog no. 70967, ISBN: 978-1-4200-7096-5 January 2009, 7 x 10, 584 pp. Suggested Price: $159.95 / £97.00

Division of Viral Hepatitis, National Center for Infectious Diseases, CDCP

Catalog no. 7368, ISBN: 978-0-8493-7368-8 January 2009, 7 x 10, 584 pp. Suggested Price: $179.95 / £99.00

Mechanistic Toxicology

26 The Molecular Basis of How

Chemicals Disrupt Biological Targets, Second Edition

Microarray Methods and Protocols

Urs A. Boelsterli

Robert S. Matson

Incorporating recent advances in molecular biology, this second edition features chapters on types of toxic responses, novel mechanisms derived from systems toxicology, and disruption of cellular signal transduction. Expanded chapters include the disruption of mitochondrial function, mitochondrial outer membrane permeabilization, and selective depletion of mitochondrial DNA. The book links molecular and cellular biology with xenobiotic toxicology and contains examples and illustrations to supplement material. Additional topics include oxidant stress, apoptotic and necrotic cell death, nuclear-receptor-mediated toxicity, and immune-mediated toxicity.

Microarray Methods and Protocols provides insight into present and future uses for microarray technology. This book presents an overview of companies providing arrays, the type of arrays available, array construction processes, substrate chemistry, array printing, and quality control. With a focus on nucleic acid microarrays of biomedical relevance and the use of microarrays in drug discovery, the text describes the application of gene expression arrays to identify drug targets for human diseases and to predict possible drug toxicity problems. The relatively new field of protein microarray technology is also discussed, including technical challenges and how they have been overcome.

Catalog no. 7272, ISBN: 978-0-8493-7272-8 2007, 6-1/8 x 9-1/4, 416 pp., Soft Cover Suggested Price: $69.95 / £27.99

Catalog no. 46659, ISBN: 978-1-4200-4665-6 January 2009, 6-1/8 x 9-1/4, 216 pp., Soft Cover Suggested Price: $129.95 / £78.99

University of Connecticut, Storrs, USA

Beckman Coulter Inc., Fullerton, California, USA

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

Edited by

Bradley J. Undem

Johns Hopkins Asthma Center, Baltimore, Maryland, USA

Atlas of Functional Neuroanatomy Second Edition

Daniel Weinreich

Walter J. Hendelman, M.D.

Taking a comprehensive approach in which all aspects of the vagal afferent system are considered, from the terminals in the visceral tissues to the neural pathways within the central nervous system, Advances in Vagal Afferent Neurobiology extensively reviews the development, neurochemistry, anatomy, biophysics, pharmacology, and physiology of the vagal afferent nerves. The text presents experimental techniques used to investigate the development, morphology, electrophysiology and reflex function of the vagal afferent nerves, and includes state-of-the-art reviews of vagal afferent neurobiology by some of the world’s leading experts in these fields.

Presenting a clear visual guide to understanding the human central nervous system, this second edition includes numerous four-color illustrations, photographs, diagrams, radiographs, and histological material throughout the text. Well-organized and easy to follow, the book presents new and revised material, including an overview of the CNS, sensory, and motor systems and the limbic system. It also features an updated, interactive CD-ROM with full text, color illustrations, 3-D visualization, roll-over labeling, and flash animations. Containing a glossary of terms, this is an essential reference tool for medical and allied health professionals studying neuroanatomy, neuroscience, and neurology.

University of Maryland, Baltimore, USA

Catalog no. 2131, ISBN: 978-0-8493-2131-3 2005, X, 544 pp. Suggested Price: $164.95 / £92.00

Animal Models of Cognitive Impairment

University of Ottawa, Ontario, Canada

Catalog no. 3084, ISBN: 978-0-8493-3084-1 2006, 8-1/2 x 11, 296 pp., Soft Cover Suggested Price: $59.95 / £34.99

Behavioral Pharmacology

Edward D. Levin

Duke University Medical Center, Durham, North Carolina, USA

Integrating the Experimental Analysis of Behavior & Neuroscience

Jerry J. Buccafusco

Steven I. Dworkin

Medical College of Georgia, Augusta, USA

Jacksonville State University, Alabama, USA

Series: Frontiers in Neuroscience, 30

Series: Frontiers in Neuroscience

Animal models of cognitive function, including learning, memory, and attention, are critical for determining the neurobehavioral basis for cognition and for the development of new therapeutic treatments for cognitive impairment. Animal Models of Cognitive Impairment features an integrated approach that combines molecular and neurochemical approaches in translational models with behavioral and clinical applications. The text also discusses current research on genetic, lesion, pharmacological toxicant, and aging models. The book then explores the significance of this research to the treatment of various addictions and disorders such as stroke, autism, Alzheimer’s, schizophrenia, and ADHD.

A valuable source for information on the behavioral consequences of pharmacological agents, this book presents general and advanced concepts and methods used in behavioral psychology, behavioral neuroscience, and CNS pharmacology. Practical considerations related to ethics, equipment, and the use of animals in biomedical research are addressed. With examples of neurobehavioral applications used to illustrate behavioral disorders, the text also covers the reinforcing effects of drugs, the value of stimulus properties of drugs, the behavioral mechanisms of drug action, and the acute and chronic effects of compounds on acquisition and performance.

Edited by

Catalog no. 2834, ISBN: 978-0-8493-2834-3 2006, 6-1/8 x 9-1/4, 400 pp. Suggested Price: $149.95 / £86.00

Neuroscience

Advances in Vagal Afferent Neurobiology

Catalog no. 47876, ISBN: 978-1-4200-4787-5 July 2009, 6-1/8 x 9-1/4, 480 pp. Suggested Price: $149.95 / £89.00

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For more information and a complete list Caffeine and Activation Theory Biology of the NMDA Receptor Edited by

Effects on Health and Behavior Edited by

Barry D. Smith

University of Maryland, College Park, USA

Antonius M. VanDongen

Duke University Medical Center, Durham, North Carolina, USA Series: Frontiers in Neuroscience

Uma Gupta

I.M.S., Banaras Hindu University, Varanasi, India

Bhupendra Gupta

Banaras Hindu University, Varanasi, India

Neuroscience

The NMDA receptor, a subclass of the ionotropic glutamate receptor family, plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. Biology of the NMDA Receptor describes all importance aspects of NMDA receptor biology. The text highlights exciting new discoveries that have been made over the past decade. It provides a comprehensive review of various molecular genetics studies that illustrate the importance of this class of receptors. In addition, the book presents a discussion of recent crystallographic X-ray structures of its ligand binding domains.

Caffeine is the single most widely consumed drug in the world. However, the very same chemical qualities that provide the widely perceived benefits also have both short term and long term effects on physiology and behavior. Caffeine and Activation Theory: Effects on Health and Behavior provides a balanced review of research and a clear understanding of what is known about the effects of caffeine, including effects on the cardiovascular system, reproduction, mood, performance, and psychopathology. It outlines specific areas where further research is needed and integrates literature reviews from leading experts in the field.

Catalog no. 44141, ISBN: 978-1-4200-4414-0 January 2009, 6-1/8 x 9-1/4, 350 pp. Suggested Price: $149.95 / £83.00

Catalog no. 7102, ISBN: 978-0-8493-7102-8 2007, 6-1/8 x 9-1/4, 400 pp. Suggested Price: $164.95 / £92.00

Brain Aging

Models, Methods, and 28 Mechanisms Edited by

David R. Riddle

Wake Forest University, Winston-Salem, North Carolina, USA Series: Frontiers in Neuroscience

Circadian Physiology Second Edition

Roberto Refinetti, Ph.D.

University of South Carolina, Allendale, USA

Bringing together critical studies of brain aging in animal models and new insights from human brain imaging, Brain Aging focuses on fundamental age-related changes in the brain rather than pathological neurodegeneration. Offering significant depth and breadth of coverage, it provides an overview of structural and functional changes at the molecular, systems, and cognitive levels. Written by pioneering researchers, it reviews unbiased methods for quantifying changes and stereological methods for clarifying the extent and nature of age-related neurological changes. It also explores the distinct methodological challenges inherent in investigating the aging nervous system.

Circadian Physiology highlights the basic processes and latest research findings in circadian biology and describes how this knowledge applies to the prevention of jet lag and the malaise associated with shift work, the treatment of sleep disorders and depression, and the timing for effective administration of medicines. The second edition is updated to include recent research developments such as the discovery of new retinal photoreceptors, the identification of several non-hypothalamic circadian pacemakers, and the elucidation of genomic and proteomic mechanisms of biological timing. Each chapter includes a summary, exercises, and suggestions for further reading.

Catalog no. 3818, ISBN: 978-0-8493-3818-2 2007, 6-1/8 x 9-1/4, 408 pp. Suggested Price: $149.95 / £86.00

Catalog no. 2233, ISBN: 978-0-8493-2233-4 2006, 8-1/2 x 11, 688 pp. Suggested Price: $129.95 / £74.99

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Computational Neuroscience

DNA Arrays

Technologies and Experimental Strategies

Realistic Modeling for Experimentalists

Edited by

Edited by University of Antwerp-UIA, Wilrijk, Belgium

Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts, USA

Series: Frontiers in Neuroscience, 5

Series: Frontiers in Neuroscience, 12

Designed primarily as an introduction to realistic modeling methods, Computational Neuroscience: Realistic Modeling for Experimentalists focuses on methodological approaches, the selection of appropriate methods, and the identification of potential pitfalls. What makes this resource unique is the inclusion of a CDROM that furnishes interactive modeling examples. It contains tutorials and demos, movies and images, and the scripts necessary to run the full simulations described in the examples. Each chapter includes theoretical foundations, parameters needed, appropriate software descriptions, evaluation of the models, future directions, examples linked to the CD-ROM, and references.

A quantum leap in technology took place several years ago with the introduction of cDNA arrays that have been developed in response to the need for simultaneous analysis of the patterns of expression of genes. This volume offers a view of different aspects of this developing technology, including oligonucleotide and electrochemical arrays. Distinguished investigators from academia and industry provide insights into methodological fundamentals of construction of DNA arrays, optimization of hybridization conditions, the use of expression data in bioinformatics, the use of different software tools, and the application of microarray technology for drug discovery process.

Catalog no. 2068, ISBN: 978-0-8493-2068-2 2001, 6-1/8 x 9-1/4, 368 pp. Suggested Price: $149.95 / £86.00

Catalog no. 2285, ISBN: 978-0-8493-2285-3 2002, 6-1/8 x 9-1/4, 184 pp. Suggested Price: $149.95 / £86.00

Concussive Brain Trauma

Neurobehavioral Impairment & Maladaption, Second Edition Rolland S. Parker

Neuroscience

Elena V. Grigorenko

Erik De Schutter

The Dynamic Synapse

Molecular Methods in Ionotropic Receptor Biology

Edited by

Josef T. Kittler and Stephen J. Moss University College of London, UK

New York University School of Medicine, USA

Series: Frontiers in Neuroscience, 29

Continuing the tradition of the best-selling first edition, this new version provides comprehensive coverage of neurobehavioral disorders in children and adults following impact and acceleration accidents. Completely revised and updated, the book includes comprehensive coverage of consciousness, including normal, acute, and persistent alterations. Drawing on his training, education, and experience in human physiology, neuroanatomy, and endocrinology, the author not only gives readers a solid foundation for understanding, diagnosing, and treating concussive brain trauma, but also gives them tools to increase standards of care.

Bringing together the latest information into one easily accessible resource, The Dynamic Synapse: Molecular Methods in Ionotropic Receptor Biology explores the diverse tools and technologies used to study synaptic processes. Written by worldrenowned leaders in the field, the book delineates newly developed techniques, methods, and conceptual advances used for studying neurotransmitter receptors and other synaptic proteins. Providing detailed information on cutting-edge techniques that can be applied to this area, the book is useful to both new and experienced synaptic physiologists as well as the wider neuroscience community.

Catalog no. 8039, ISBN: 978-0-8493-8039-6 July 2009, 7 x 10, 530 pp. Suggested Price: $159.95 / £97.00

Catalog no. 1891, ISBN: 978-0-8493-1891-7 2006, 6-1/8 x 9-1/4, 336 pp. Suggested Price: $159.95 / £92.00

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For more information and a complete list Electrochemical Methods for Neuroscience

Fat Detection

Edited by

Jean-Pierre Montmayeur

Taste, Texture, and Post Ingestive Effects

Adrian C. Michael and Laura M. Borland

Centre des Sciences du Hout, Dijon, France

Frontiers in Neuroengineering Series, 33

Series: Frontiers in Neuroscience

This volume provides an updated summary of the current state of the art and lays the scientific foundation for incorporating electrochemical techniques into emerging research. It explores the methodology behind the acquisition of neurochemical and neurobiological data through continuous amperometry, fast scan cyclic voltammetry, high-speed chronoamperometry, ion-selective microelectrodes, enzyme based microelectrodes, and in vivo voltammetry with telemetry. The text also introduces emerging concepts such as the correlation of electrochemical recordings with information obtained from patch clamp, electrophysiological, and behavioral techniques.

Taking a multidisciplinary approach, this volume sheds new light on critical concerns regarding dietary fat and its relation to obesity. Going far beyond the well-known concerns, it offers new scientific data on the many aspects of fat consumption including psychological, behavioral, genetic, and physiologic factors that contribute to its desirability, perception, intake, and impact on human health. Bringing together research from across various fields, it includes information on genetic predisposition, neural imaging, and endocrine function impacts on metabolism. It also provides a progressive integrated view on fat taste, fat preference, and nutrition at the molecular level.

Catalog no. 4075, ISBN: 978-0-8493-4075-8 2007, 7 x 10, 544 pp. Suggested Price: $159.95 / £92.00

Catalog no. 67753, ISBN: 978-1-4200-6775-0 June 2009, 6-1/8 x 9-1/4, 512 pp. Suggested Price: $149.95 / £89.00

University of Pittsburgh, Pennsylvania, USA

Johannes le Coutre

Nestle Research Center, Lausanne, Switerland

Neuroscience

Endocannabinoids The Brain and Body’s Marijuana and Beyond Edited by

Emmanuel S. Onaivi

William Paterson University, Wayne, New Jersey, USA

Takayuki Sugiura

Teikyo University, Kanagawa, Japan

The Female Brain Second Edition Cynthia Darlington

Vincenzo Di Marzo

University of Otago, Dunedin, NewZealand

Dirigente di Ricerca, Puzzuoli, Napoli, Italy

Series: Conceptual Advances in Brain Research, 9

This volume explores research on marijuana-like substances produced naturally by the human body and brain. These endogenous lipid molecules, or endocannabinoids, constitute a uniquely conserved and ubiquitous physiological control system in a variety of species and play fundamental roles in development and cell death. The book discusses this remarkable progress in marijuana research, including identification of gene-encoding endocannabinoid receptors, isolation of endocannabinoids and entourage ligands, and functional identification of transporters and enzymes for the biosynthesis and degradation of these endogenous substances.

In experimental disciplines such as neuroanatomy, neurophysiology, neuropharmacology, and experimental psychology, male animals have been used as subjects more than females, skewing the results. The first edition of this work laid the groundwork for gaining a better understanding of the female brain. Likewise, this volume continues to evaluate the evidence for structural and functional differences between the brains of males and females. The text leads the reader from basic principles of anatomy and physiology to complex behavioral functions that constitute the workings of the normal (and abnormal) female brain. This edition addresses a wealth of new research that has recently surfaced.

Catalog no. TF1609, ISBN: 978-0-415-30008-7 2006, 7 x 10, 584 pp. Suggested Price: $164.95 / £92.00

Catalog no. 77449, ISBN: 978-1-4200-7744-5 April 2009, 6-1/8 x 9-1/4, 248 pp. Suggested Price: $129.95 / £78.99

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Frontiers in the Neurobiology of Addiction

Indwelling Neural Implants

Cynthia M. Kuhn

Duke University Medical Center, Durham, North Carolina, USA

George F. Koob

Strategies for Contending with the In Vivo Environment Edited by

The Scripps Research Institute, La Jolla, California, USA

William M. Reichert

Series: Frontiers in Neuroscience

Frontiers in Neuroengineering Series

Featuring contributions from leading experts, this book presents an excellent overview of the available and emerging approaches used to investigate the biologic mechanisms of drug addiction. Discussion includes the behavioral strategies and characteristics of addiction as well as the mechanistic approaches to understanding the underlying neurobiology. The contributors provide information from mathematical models; model organisms; traditional, wellcharacterized animal models; and experiments conducted on humans. They deliver a comprehensive introduction to the methodologies of the field for students and beginning researchers and an essential reference source for established investigators.

A compendium of contributions from noted experts in neuroprosthetics and tissue repair, this book addresses the impact, characterization, and mitigation of the healing of tissues that surround an implant. It describes the differences among wound healing in the CNS, PNS, subcutaneous tissue, and bone. It also examines performance issues of implanted neuroprosthetics arising from the chemical, mechanical, thermal, and electrical impact on surrounding tissue. Contributions present both in vitro and in vivo approaches to assessing wound healing response to materials and describe molecular and materials strategies for intervening in CNS wound repair and enhancing the electrical communication between electrode and surrounding tissue.

Catalog no. 7391, ISBN: 978-0-8493-7391-6 June 2009, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $139.95 / £85.00

In Vivo Optical Imaging of Brain Function

Duke University, Durham, North Carolina, USA

Neuroscience

Edited by

Catalog no. 9362, ISBN: 978-0-8493-9362-4 2008, 6-1/8 x 9-1/4, 296 pp. Suggested Price: $149.95 / £86.00

Textbook

The Integrated Nervous System

Second Edition

Walter Hendelman, M.D.

Edited by

University of Ottawa, Ontario, Canada

Peter Humphreys

Ron Frostig

University of California, Irvine, Irvine, California, USA

Children’s Hospital of Eastern Ontario, Canada

Series: Frontiers in Neuroscience, 39

Ottawa Hospital, Ontario Canada

Updated to reflect continuous development in this emerging area, this new edition, like the original, reaches across disciplines to review a variety of noninvasive optical techniques used to study activity in the living brain. Leading authorities from such diverse areas as optical hardware, cognitive behavior, and neuroscience present a host of perspectives that range from a single neuron to large assemblies of neurons several million strong, captured at various temporal and spatial resolutions. Techniques are introduced that were not available just a few years ago. They allow for procedures such as imaging of mitochondria, cortical mapping, and imaging of brains fully awake and engaged.

To demonstrate the connection between academic neuroanatomy and the practice of clinical neurology, this innovative textbook presents carefully chosen clinical cases that illustrate how the nervous system is constructed and how it functions under normal circumstances. Providing the foundation needed to encounter neurological diseases, it teaches students and residents how to integrate a patient’s clinical history and examination with neuroanatomy. In addition to color illustrations throughout, the book adds animation and video clips with an included CD-ROM. It also provides links to sites that explain various examinations and special tests. An instructor’s manual is available for qualifying instructors.

Catalog no. 76841, ISBN: 978-1-4200-7684-4 April 2009, 6-1/8 x 9-1/4, 528 pp. Suggested Price: $149.95 / £89.00

Catalog no. 45970, ISBN: 978-1-4200-4597-0 August 2009, 7 x 10, 500 pp. Suggested Price: $79.95 / £48.99

Christopher R. Skinner

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For more information and a complete list Methods in AlcoholRelated Neuroscience Research Edited by

Manual of Stroke Models in Rats Edited by

Yanlin Wang-Fischer

Palatin Technologies, Cranbury, New Jersey, USA

Neuroscience

While new insights into the mechanisms and the treatment of stroke have been obtained from animal experiments over the past several years, this is the first book in more than two decades to compile research in this essential area. Calling on a group of cutting-edge researchers, it offers detailed explanations of the methods and techniques for accomplishing different stroke models in rats. As of now, no specific neuroprotective treatment for ischemic stroke is available. This book provides a starting point for those researchers employing stroke models to develop new drugs to counteract this problem. Catalog no. 9578, ISBN: 978-0-8493-9578-9 January 2009, 7 x 10, 352 pp., Soft Cover Suggested Price: $99.95 / £55.99

Methods for Neural Ensemble Recordings

32 Second Edition Edited by

Yuan Liu

National Institute of Neurological Disorders & Stroke, Bethesda, Maryland, USA

David M. Lovinger

Laboratory of Integrative Neuroscience, National Institute on Alcohole Abuse and Alcoholism, Nashville, Tennessee, USA Series: Frontiers in Neuroscience, 14

Written by a panel of experts, Methods in Alcohol-Related Neuroscience Research not only provides information of a technical nature but also gives an overview of the many areas in investigating the effects of alcohol on the brain. It presents technical guidance for investigators doing research at the molecular, cellular, systems, and behavioral levels. These techniques include a wide variety of approaches, ranging from gene mapping and examination of molecular interactions of alcohol at the sub-cellular level to recording of neural activities in freely-behaving animals and imaging alcohol effects on the living human brain. Catalog no. 0347, ISBN: 978-0-8493-0203-9 2002, 6-1/8 x 9-1/4, 416 pp. Suggested Price: $149.95 / £86.00

Methods in Chemosensory Research Edited by

Miguel A. L. Nicolelis

Sidney A. Simon and Miguel A.L. Nicolelis

Series: Frontiers in Neuroscience

Series: Frontiers in Neuroscience, 9

The second edition of this best-selling reference distills the current state-of-the-science and provides the foundation of the methods involved in this rapidly growing science. With contributions from pioneering researchers, it includes microwire array design for chronic neural recordings, new surgical techniques for chronic implantation, microelectrode microstimulation of brain tissue, multielectrode recordings in the somatosensory system and during learning, as well as recordings from the central gustatory-reward pathways. It explores the use of brain-machine interface to restore neurological function and proposes conceptual and technical approaches to human neural ensemble recordings.

Methods in Chemosensory Research describes new molecular, electrophysiological, engineering, genetic, behavioral, psychophysical, and imaging techniques that have recently been adapted to investigate the basic neuronal mechanisms underlying chemoreception. Written by leaders in the field of neuronal chemoreception specializing in olfaction, gustation, baroreception, and chemical irritation caused by environmental pollutants, this unique book combines novel methods to investigate all aspects of taste and olfaction. These methods range from the molecular level to the investigation of individual cell taste and olfactory epithelia.

Duke University Medical Center, Durham, North Carolina, USA

Catalog no. 7046, ISBN: 978-0-8493-7046-5 2008, 6-1/8 x 9-1/4, 296 pp. Suggested Price: $149.95 / £86.00

Duke University Medical Center, Durham, North Carolina, USA

Catalog no. 2329, ISBN: 978-0-8493-2329-4 2002, 6-1/8 x 9-1/4, 552 pp. Suggested Price: $149.95 / £86.00

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Methods in Drug Abuse Research

Cellular and Circuit Level Analyses Edited by

Methods in Pain Research Edited by

MCP-Hahnemann School of Medicine, Philadelphia, Pennsylvania, USA

Lawrence Kruger

University of California, Los Angeles, USA

Series: Frontiers in Neuroscience, 17

Series: Frontiers in Neuroscience, 6

Pulling information from a wide variety of resources and assembling it into one volume, this book examines cellular and molecular studies of drug actions and behavioral approaches to questions in drug abuse research. The book covers procedures, methods, and equipment used in experiments that in many cases, combine multiple technical approaches. It presents state-of-the-art technical information and critical reviews of the experimental strategies used to dissect the problem of compulsive drug use and addiction at the systems or whole brain level. It also provides insight into the pros and cons of various experimental strategies.

Addressing a rapidly growing area of neuroscience, Methods in Pain Research is a single volume survey of the methods used to study a reaction or ‘sensory report’ in humans that can only be inferred by indirect means in animal or tissues studies. It contains source material and guidance on specific details as well as examples of current usage. The book examines techniques used in studying pain, including gene linkage, brain imaging methods, the use of transgenic rodent models, painful sensory neuropathy models, and more. The material also covers conventional methods of pain study, such as anatomical and electophysiological techniques

Catalog no. 2345, ISBN: 978-0-8493-2345-4 2003, 6-1/8 x 9-1/4, 296 pp. Suggested Price: $149.95 / £86.00

Catalog no. 0035, ISBN: 978-0-8493-0035-6 2001, 6-1/8 x 9-1/4, 336 pp. Suggested Price: $159.95 / £92.00

Methods in Insect Sensory Neuroscience

Methods of Behavior Analysis in Neuroscience

Neuroscience

Barry D. Waterhouse

Second Edition

Edited by

Thomas A. Christensen

Jerry J. Buccafusco

University of Arizona, Tucson, USA

Medical College of Georgia, Augusta, USA

Series: Frontiers in Neuroscience, 25

Series: Frontiers in Neuroscience

Written by recognized experts in sensory biology, Methods in Insect Sensory Neuroscience synthesizes the latest information and reviews the most current methods for studying the specialized sensory systems of insects. Bridging the gap between experimentalists and theorists, the book covers a wide range of techniques, including anatomical pathway tracing, electrophysiological recording, genetic and pharmacological manipulations, computational modeling, and behavioral observations. Each chapter discusses the most challenging questions facing sensory neuroscience today and provides a unique synopsis of the developments that are driving the field forward.

A comprehensive reference for the most well-studied behavioral approaches in animal subjects, this book provides a better understanding of disease effects and new therapeutic treatments. The second edition features new material on the relevance of transgenic mouse models for Alzheimer’s disease, behavioral methods for assessing the cognitive impairment associated with major psychotic disorders, the revival of the scopolamine reversal model for assessing the clinical relevance of new AD drugs, and new approaches to assessing cognitive impairment in aged mice. Each chapter presents theoretical background, methodology, and data interpretation.

Catalog no. 2024, ISBN: 978-0-8493-2024-8 2005, 6-1/8 x 9-1/4, 464 pp. Suggested Price: $149.95 / £86.00

Catalog no. 52349, ISBN: 978-1-4200-5234-3 January 2009, 6-1/8 x 9-1/4, 360 pp. Suggested Price: $149.95 / £83.00

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For more information and a complete list Micronutrients and Brain Health Lester Packer and Enrique Cadenas

University of Southern California, Los Angeles, USA

Helmut Sies

Motor Cortex in Voluntary Movements A Distributed System for Distributed Functions

Heinrich-Heine-Universitaet, Dusseldorf, Germany

Edited by

Manfred Eggersdorfer

Institut de Neurosciences Cognitives De La Mediterranee - CNRS, Marseille, France

DSM Nutritional Products Ltd., Basel, Switzerland Series: Oxidative Stress and Disease

Neuroscience

Under the direction of leading experts in oxidative stress, this book addresses cutting-edge areas of research regarding micronutrients and the brain. It discusses identification of brain-specific micronutrients that support function and molecular mechanisms underlying neuroprotectant activity. The book covers age-related metabolic pathways, mitochondrial nutrients, and neurodegeneration. Additional chapters cover flavonoids, cell signaling, and neuronal functions, as well as the role of choline, amino acids, metals, and other micronutrients in brain health and function. The text places a particular emphasis on lipoic acid, which is shown to be a therapeutic agent in neuropathologies. Catalog no. 73516, ISBN: 978-1-4200-7351-5 July 2009, 6-1/8 x 9-1/4, 448 pp. Suggested Price: $169.95 / £103.00

Modern Neurosurgery

34 Clinical Translation of

Neuroscience Advances Edited by

Dennis A. Turner

Duke University Medical Center, Durham, North Carolina, USA

Focusing how increased understanding of brain function affects clinical neuroscience, Modern Neurosurgery: Clinical Translation of Neuroscience Advances explores the interface between nonclinical and clinical neuroscience advances by examining the hypotheses that drive this evolution. The book reviews the relevant underpinnings of new neurosurgical techniques, treatments, and conceptual approaches, which are likely to shape clinical neuroscience over the next decade. A critical aspect of this rational approach is to underscore what needs to be done in each field, potentially leading to further study and improvements. Catalog no. 1482, ISBN: 978-0-8493-1482-7 2004, 344 pp. Suggested Price: $149.95 / £86.00

Alexa Riehle

Eilon Vaadia

The Hebrew University, Jerusalem, Israel

This book presents the most current developments in motor cortex research that allow researchers to read and interpret neural activity and use the data to reconstruct movements. It focuses on how neuronal activity changes during learning, what the motor cortex encodes for, and the neuronal representations of voluntary movements and the mechanism of their generation during learning. Along with its detailed coverage of recent advanced approaches to motor cortex research, the book also includes early historical notes and brief descriptions of classical studies of neuronal activity in frontal sensorimotor fields. Catalog no. 1287, ISBN: 978-0-8493-1287-8 2005, 448 pp. Suggested Price: $149.95 / £86.00

Motor Neurobiology of the Spinal Cord Edited by

Timothy C. Cope

Wright State University, Dayton, Ohio, USA Series: Frontiers in Neuroscience, 7

Motor Neurobiology of the Spinal Cord provides a comprehensive description of the experimental tools available for investigating the neuronal properties that allow populations of spinal cord neurons to control muscles responsible for limb movements and posture control. By integrating data from many new approaches, this text demonstrates how spinal cord circuits operate under a variety conditions and explores the new and exciting developments that are being made in motor neurobiology of the spinal cord. It also elucidates concepts and principles relevant to function and structure throughout the nervous system and presents information about changes induced by injury and disease. Catalog no. 0006, ISBN: 978-0-8493-0006-6 2001, 6-1/8 x 9-1/4, 360 pp. Suggested Price: $159.95 / £92.00

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Neural Plasticity and Memory From Genes to Brain Imaging

Neural Prostheses for Restoration of Sensory and Motor Function Edited by

John K. Chapin

Edited by

State University of New York Health Science Center, USA

Federico Bermúdez-Rattoni

Karen A. Moxon

Series: Frontiers in Neuroscience

Series: Frontiers in Neuroscience, 4

This latest offering in the Frontiers in Neuroscience series provides a multidisciplinary review of research being conducted on the neurobiology of memory. This volume examines the synaptic communication elements identified as being susceptible to modification through the accumulation of experience. It explains how cell circuitry is modulated and ultimately modified by neurotransmitters and hormones during the process of acquiring, consolidating, and retrieving information. In each chapter, researchers present findings, while explaining their innovative methodologies. This text also addresses current memory studies involving human brain imaging.

While the creation of a bionic human may still be far into the future, neural prostheses are rapidly becoming viable for patients with injury or disease of the nervous system. This book provides information on the recent advances in neural prosthetic techniques and applications. Divided into two sections, the first section details some of the most successful sensory and motor prosthetic devices available, paying particular attention to the current usefulness and future promise of these devices. The second section explores the growing field of brain-implantable devices for the control of neural prosthetics and artificial prosthetic devices.

Catalog no. 9070, ISBN: 978-0-8493-9070-8 2007, 6-1/8 x 9-1/4, 368 pp. Suggested Price: $149.95 / £86.00

Neural Plasticity in Adult Somatic Sensory-Motor Systems Edited by

Ford F. Ebner

Vanderbilt University, Nashville, Tennessee, USA

Drexel University, Philadelphia, Pennsylvania, USA

Neuroscience

National University of Mexico, Mexico City, Distrito Federal

Catalog no. 2225, ISBN: 978-0-8493-2225-9 2001, 6-1/8 x 9-1/4, 312 pp. Suggested Price: $149.95 / £86.00

Neuroanatomical Basis of Clinical Neurology

Orhan Arslan

Series: Frontiers in Neuroscience, 27

University of South Florida, Tampa, USA

Synthesizing current information about sensory-motor plasticity, this book provides an up-to-date description of the dynamic processes that occur in somatic sensory-motor cortical circuits or somatic sensory pathways to the cortex due to experience, learning, or damage to the nervous system. The presentation emphasizes changes in the cortex that are linked to changes in movement or behavior, and it demonstrates the potential for direct brain-based interventions to improve the quality of life for people with sensorymotor disabilities. The book includes studies that document the dynamic changes in system properties that occur with normal experience or in recovery from brain damage.

Superbly illustrated and clearly written, Neuroanatomical Basis of Clinical Neurology bridges the gap between the disciplines of neuroanatomy and neurology, aiding the understanding of neurologic disorders by investigating their anatomic basis. The extensive coverage of the peripheral and central nervous systems in the context of neurological disorders and conditions sets it apart from other neuroanatomy texts. The author has skilfully integrated text and diagrams, highlighting and clarifying the numerous functionally important pathways in the central and peripheral nervous systems. This volume was chosen as an Outstanding Academic Title for 2002 by CHOICE Magazine.

Catalog no. 1521, ISBN: 978-0-8493-1521-3 2005, 6-1/8 x 9-1/4, 296 pp. Suggested Price: $149.95 / £86.00

Catalog no. PA578X, ISBN: 978-1-85070-578-9 2002, 8-1/2 x 11, 432 pp., Soft Cover Suggested Price: $67.95 / £37.99

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For more information and a complete list Neurobehavioral Genetics

Methods and Applications, Second Edition Edited by

Byron C. Jones

Pennsylvania State University, University Park, USA

Edited by

Neuroscience

Pierre Mormède

Steven B. Karch, MD, FFFLM

INRA, Head-Laboratoire de Neurogenetique et Stress, Bordeaux, France

Consultant Cardiac Pathologist & Toxicologist, Berkeley, California, USA

Neurobehavioral Genetics: Methods and Applications, Second Edition features a broad spectrum of techniques in neurobehavioral genetics. Providing solid historical background, the introductory chapters examine past conceptual streams of behavior genetics. Later chapters discuss the applications of quantitative and molecular genetics in basic and clinical research. This edition offers a contemporary approach to the study of the brain and behavior. It also serves as an excellent resource for investigators who want to incorporate genetic methods into neurobehavioral and psychiatric research.

Beginning with a detailed look at individual drugs and their mechanisms, Neurochemistry of Abused Drugs considers changes in neurotransmitter levels and discusses the relationship of these changes to the nature and phenomenon of addiction. New studies highlight the addictive capacity and neurochemical and neurobehavioral consequences of MDMA, methamphetamine, nicotine, and cocaine use. Recent discoveries regarding the neurotransmitter systems involved in each of these drugs reveal new therapeutic targets and novel compounds that may aid in alleviating addiction. Extensively referenced and citing numerous studies, this book provides unparalleled insight into the actions and potential inhibition of abused drugs.

Catalog no. 1903, ISBN: 978-0-8493-1903-7 2007, 6-1/8 x 9-1/4, 496 pp. Suggested Price: $149.95 / £86.00

Neurochemistry of Abused Drugs

The Neurobiology of Huntington’s Disease

Catalog no. 54414, ISBN: 978-1-4200-5441-5 2008, 7 x 10, 168 pp. Suggested Price: $83.95 / £46.99

New Concepts in Cerebral Ischemia

Donald C. Lo

Edited by

Robert E. Hughes

Novato, California, USA

University of Mississippi Medical Center, Jackson, USA

Series: Frontiers in Neuroscience

Series: Frontiers in Neuroscience, 13

Highlighting advances in the discovery and development of new drug therapies for neurodegenerative disorders, this volume focuses on the many aspects of the research on drugs to treat Huntington’s disease. It discusses genetics, genomics, and proteomics, and the latest in high-throughput and high-content screening. The authors provide introductory background as well as highly sophisticated information on current and future directions of research. Exploring the interplay between academic and industrial research, the investment community, and non-profit contributors, the book also examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage.

Providing a detailed description of the techniques and theories employed in both basic and clinical research, New Concepts in Cerebral Ischemia delineates the mechanisms underlying neuronal damage induced by ischemia. The book covers methods to elucidate the pathogenesis of ischemia, technologies used in the design of specific strategies to protect neurons from further injury, and new approaches to treating patients with acute ischemic episodes. It includes methods and therapeutic approaches for neuronal protection against acute and chronic ischemic episodes and describes new animal models for ischemia research, including the application of transgenic animals.

Catalog no. 9000, ISBN: 978-0-8493-9000-5 May 2009, 6-1/8 x 9-1/4, 384 pp. Suggested Price: $139.95 / £85.00

Catalog no. 0328, ISBN: 978-0-8493-0119-3 2002, 6-1/8 x 9-1/4, 328 pp. Suggested Price: $149.95 / £86.00

Durham, North Carolina, USA

Rick C.S. Lin

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

Edited by

From Infancy and Childhood through Adolescence

Edward D. Levin

Edited by

Duke University Medical Center, Durham, North Carolina, USA Series: Frontiers in Neuroscience, 8

Featuring a unique approach, Nicotinic Receptors in the Nervous System provides integrated coverage of research on neuronal nicotinic systems relevant to smoking addiction and cognitive dysfunction. By bringing together molecular and neurochemical applications, the book provides the key to understanding function and dysfunction of nicotinic systems and how they are significant for disease, addiction, and the development of novel drug treatments. The book presents readers with the basic mechanistic background for these treatments as well as the functional assessment necessary to determine therapeutic effects. Catalog no. 2386, ISBN: 978-0-8493-2386-7 2002, 6-1/8 x 9-1/4, 312 pp. Suggested Price: $149.95 / £86.00

Parkinson’s Disease Edited by

Kevin Chapman and Jong M. Rho

Barrow Neurological Institute, Phoenix, Arizona, USA

Organized chronologically, from neonate through adolescence, this unique work serves as a quick reference guide, offering insight into the various age-related pediatric epilepsy syndromes. A compilation of extensive case studies by more than 35 renowned physicians, it covers the various aspects of pediatric epilepsy, offers in-depth discussions into the disease’s pathophysiology, and explores current treatment strategies. An extensive resource section saves time by providing an authoritative guide to the most relevant findings scattered in the literature. Certain to become a classic, this is an essential resource for all pediatricians, as well as researchers and clinicians involved with epilepsy. Catalog no. 83422, ISBN: 978-1-4200-8342-2 January 2009, 6-1/8 x 9-1/4, 296 pp. Suggested Price: $79.95 / £44.99

Primate Audition

Ethology and Neurobiology

Manuchair Ebadi

University of North Dakota, Grand Forks, USA

Ronald F. Pfeiffer

Edited by

Asif A. Ghazanfar

University of Tennessee Health Science Center, Memphis, USA

Princeton University, New Jersey, USA

A new optimism that Parkinson’s disease can be defeated is energizing the research community. Halting the progression of the disease, restoring function, and even prevention are all realistic goals. This comprehensive volume provides state-of-the-art information on all aspects of Parkinson’s disease, including epidemiology, genetics, diagnosis, treatment, and social issues. Novel and attractive models are included to simplify difficult-to-understand concepts. With a focus on therapeutics and written by leaders in the field, Parkinson’s Disease emphasizes both the importance of early diagnosis and the search for more effective therapies.

Bringing together the knowledge of world experts on different aspects of primate auditory function, this book narrows the epistemological gap between primate ethologists and auditory neurobiologists. Leading ethologists, comparative psychologists, and neuroscientists who have developed new experimental approaches apply their methods to a variety of issues dealing with primate vocal behavior and the neurobiology of the primate auditory system. The synthesis of ethological and neurobiological approaches to primate vocal behavior presented in this book will yield a rich understanding of the acoustic and neural bases of primate audition and shed light on the evolutionary precursors to speech.

Catalog no. 1590, ISBN: 978-0-8493-1590-9 2005, 8-1/2 x 11, 1080 pp. Suggested Price: $229.95 / £128.00

Neuroscience

Nicotinic Receptors in the Nervous System

Pediatric Epilepsy Case Studies

Series: Frontiers in Neuroscience, 16

Catalog no. 0956, ISBN: 978-0-8493-0956-4 2003, 6-1/8 x 9-1/4, 336 pp. Suggested Price: $159.95 / £92.00

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For more information and a complete list

The Primate Visual System

Sensory-Directed Flavor Analysis

Edited by

Jon H. Kaas and Christine E. Collins

Ray Marsili

Series: Frontiers in Neuroscience, 20

Series: Food Science and Technology, 163

Discussing the neural behavior of visuomotor processing in the primate brain, this book synthesizes current knowledge on the anatomical and functional organization of the primate visual system and proposes new directions for research. It describes state-of-theart methods for investigating the visual system and includes coverage of how the visual system is formed during development. With contributions from a multidisciplinary group of leading researchers, the book considers a range of topics concerning various primates, including humans, and covers processing from the eye to neural codes for action, and from basic perception to memory.

Sensory-Directed Flavor Analysis helps chemists unlock the flavor secrets that may be hiding in their chromatograms by translating cold hard numbers into a better understanding of the sense of smell and taste. Using more ancillary techniques helps sensory scientists and analytical chemists elucidate how various chemical constituents influence food flavor and appeal. The book discusses important enabling technologies and analytical methods including GColfactometry and the application of odor activity values, as well as solid-phase dynamic extraction and preseparation techniques. The book provides a broad array of applications, in addition to dozens of gas chromatograms and illustrations.

Vanderbilt University, Nashville, Tennessee, USA

Neuroscience

Catalog no. 1243, ISBN: 978-0-8493-1243-4 2004, 6-1/8 x 9-1/4, 440 pp. Suggested Price: $149.95 / £86.00

Belvidere, Illinois, USA

Catalog no. DK3667, ISBN: 978-1-57444-568-8 2007, 6 x 9, 288 pp. Suggested Price: $209.95 / £117.00

The Role of the Nucleus of the Solitary Tract in Gustatory Processing

Serotonin Receptors in Neurobiology

Edited by

Robert M. Bradley

Amitabha Chattopadhyay

Series: Frontiers in Neuroscience, 32

Series: Frontiers in Neuroscience

The nucleus of the solitary tract (NST) provides an essential brainstem relay for three cranial nerves, coordinating highly complex sensory information. While other functions of the NST have received attention, its role in gustatory processing has received little. This work is the first reference on the NST devoted exclusively to gustatory processing. Compiling past and current research into a single volume, it documents the anatomy of the NST, explores the properties of synaptic transmitters and neurons in the NST, compares the gustatory NST with the caudal NST, and considers the challenge involved with identifying NST neural circuits, as well as other areas needing research.

Modulating mood, appetite, sexual activity, body temperature, and sleep, serotonin has implications in numerous disease states, including depression, anxiety, social phobia, schizophrenia, obsessive-compulsive disorder, and panic disorder. Providing the first comprehensive book on the subject from a multidisciplinary perspective, Serotonin Receptors in Neurobiology is among the first books to be published after serotonin receptor knock-out studies. With contributions from leading experts in their fields, this book covers a range of topics from contemporary techniques in receptor research to fundamental interactions of the 5-HT receptors with the lipid bilayer to behavioral studies.

Catalog no. 4200, ISBN: 978-0-8493-4200-4 2007, 6-1/8 x 9-1/4, 158 pp. Suggested Price: $159.95 / £92.00

Catalog no. 3977, ISBN: 978-0-8493-3977-6 2007, 6-1/8 x 9-1/4, 224 pp. Suggested Price: $144.95 / £79.99

University of Michigan, School of Dentistry, Ann Arbor, USA

Center for Cellular & Molecular Biology, Hyderabad, India

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m The Superior Colliculus

New Approaches for Studying Sensorimotor Integration

Sleep

Circuits and Functions Edited by

Edited by

William C. Hall

Duke University, Durham, North Carolina, USA

Pierre-Hervé Luppi

Adonis Moschovakis

This comprehensive book discusses the major discoveries related to the circuits responsible for slow wave sleep (SWS), rapid eye movement (REM) sleep, narcolepsy, and the possible role of sleep in memory and developmental processes. It also presents recent advances in sleep research obtained by means of emerging technologies. Sleep: Circuits and Functions includes new data obtained by differential gene expression analysis, transgenic mice, and functional imaging as well as new theoretical concepts on the mechanisms regulating sleep.

Presenting information amassed from more than 30 years of research, this book gathers together the most important pieces of evidence regarding the structure and function of the superior colliculus. It explores the involvement of the superior colliculus in the control of gaze shift and rapid eye movements and provides a detailed discussion of structural features as they relate to functional properties. Placing empirical data in the context of theory, the editors use computational models of the superior colliculus as scaffolds around which to organize psychophysical, neurological, anatomical, and physiological findings concerning its involvement in orienting movements.

University of Crete, Heraklion, Greece

Catalog no. 1519, ISBN: 978-0-8493-1519-0 2005, 272 pp. Suggested Price: $149.95 / £86.00

The Somatosensory System

Catalog no. 0643, ISBN: 978-0-8493-0097-4 2004, 344 pp. Suggested Price: $159.95 / £92.00

Edited by

A Theory of the Basal Ganglia and Their Disorders

Randall J. Nelson

Robert Miller

University of Tennessee, Memphis, USA

University of Otago, Dunedin, New Zealand

Series: Frontiers in Neuroscience, 11

Series: Conceptual Advances in Brain Research

Exploring new and past research in the understanding of how the brain deals with its own body image, this book provides a review of pertinent literature and offers comprehensive descriptions of technical approaches. The material includes new frameworks for the conceptualization of the system’s representations, scientific and clinical applications that stem from these approaches based on the new concepts, and a discussion of tools used to study the interface of the brain and the body. The book provides computational strategies for sensorimotor integration of the mammalian brain and includes algorithms for the design and implementation of haptic interfaces and tactile displacement.

Although there is a wealth of information available on basal ganglia, this research field remains controversial due in part to the diverse number of disciplines involved. A Theory of the Basal Ganglia and Their Disorders attempts to provide a clear, coherent view of basal ganglia that integrates evidence from the basic neurosciences, neurology, and psychiatry. Part I of the text develops a conceptual theory based on the normal function of basal ganglia. Part II details the mechanisms that relate basic pathology to the manifestation of symptoms for related disorders, including Huntington’s disease, Parkinson’s disease, dopamine-related psychosis, and other psychotic disorders.

Catalog no. 2336, ISBN: 978-0-8493-2336-2 2002, 6-1/8 x 9-1/4, 424 pp. Suggested Price: $149.95 / £86.00

Catalog no. 58975, ISBN: 978-1-4200-5897-0 2008, 6-1/8 x 9-1/4, 312 pp. Suggested Price: $164.95 / £92.00

Deciphering the Brain’s Own Body Image

Neuroscience

Univeristy of Lyon, France

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For more information and a complete list The Third Histamine Receptor

Selective Ligands as Potential Therapeutic Agents in CNS Disorders

From Basic Neuroscience to Treatment Edited by

Steven O. Moldin

Edited by

University of Southern California, Washington, DC, USA

Divya Vohora

John L.R. Rubenstein

Since their discovery, histamine H3 receptor ligands in various CNS disorders have received much attention. This resource presents recent advances with an emphasis on pharmacology. It covers identification and localization of receptors and the development of novel ligands incorporating pre-clinical and clinical studies indicating earliest possible stages of development. The book provides an overview of histamine as a neurotransmitter and discusses receptor pharmacology, signal transduction, selective ligands, and therapeutic potential. Several chapters address disorders involving H3, including Alzheimer’s, ADHD, sleep disorders, epilepsy, obesity, and psychiatric and neurodegenerative disorders.

Integrating basic and clinical neuroscience perspectives, Understanding Autism: From Basic Neuroscience to Treatment presents a comprehensive perspective on current autism research including epidemiology, genetics, and clinical neuroscience and neural systems. An underlying theme focuses on future genomic research, and the text also explores social, economic, and advocacy issues. With contributions from leading experts in this important and growing field of research, it stimulates new directions for research and the development of new drug treatment. The authoritative strength of this work is destined to move autism research into its rightfully prominent place in modern medicine.

Catalog no. 53922, ISBN: 978-1-4200-5392-0 January 2009, 6-1/8 x 9-1/4, 400 pp. Suggested Price: $159.95 / £89.00

Catalog no. 2732, ISBN: 978-0-8493-2732-2 2006, 6-1/8 x 9-1/4, 552 pp. Suggested Price: $175.95 / £98.00

Hamdard University, New Delhi, India

Neuroscience 40

Understanding Autism

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades Edited by

Wolfgang B. Liedtke

Duke University Medical Center, Durham, North Carolina, USA With Stefan Heller

University of California, San Francisco, USA

XIth International Symposium on Amyloidosis Edited by

Martha Skinner, John L. Berk, Lawreen H. Connors, and David C. Seldin Boston University School of Medicine, Massachusetts, USA

TRP channels have been shown to respond to a wide range of stimuli from both within and outside the cell. How we sense heat and cold, how eggs become fertile, how the heart expands and contracts is each dependent on the function of these channels. TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades offers 31 chapters written by cutting-edge researchers. It highlights progress in the elucidation of the in-vivo function of the various members of the TRP ion channel family, and examines research leading up to the development of novel pharmaceuticals for the treatment of cancer, heart disease, and immune system dysfunctions.

Edited by a stellar team of scientists, the XIth International Symposium on Amyloidosis represents the most important review of the state-of-the-science and future directions of the field. An unparalleled cast of pioneering researchers, including keynote speaker and Nobel Laureate Dr. Stanley Prusiner, present groundbreaking research in systemic amyloidosis, including the mechanisms of disease and cellular toxicity, AA amyloidosis, familial amyloidosis, AL amyloidosis, clinical trials, and emerging translational approaches. Focusing on new basic and translational medicine approaches, this book is an invaluable reference to the most up-to-date research in the field.

Catalog no. 4048, ISBN: 978-0-8493-4048-2 2007, 6-1/8 x 9-1/4, 467 pp. Suggested Price: $159.95 / £92.00

Catalog no. 42815, ISBN: 978-1-4200-4281-8 2008, 7 x 10, 432 pp. Suggested Price: $185.95 / £103.00

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Textbook

Advanced Nutrition Macronutrients, Micronutrients, and Metabolism

Carbohydrate-Active Enzymes

Carolyn D. Berdanier

Structure, Function and Applications

University of Georgia, Athens, USA

Edited by

Janos Zempleni

K-H Park

Integrating nutrition science with biochemistry, genetics, and physiology, this text presents key concepts in nutrition science, with emphasis on the role of macro- and micronutrients in metabolism. Revising and expanding information from Advanced Nutrition Micronutrients and Advanced Nutrition Macronutrients, Second Edition, this renovated work includes new chapters on the regulation of food intake, daily recommendations, nutrition assessment, metabolism, toxicology, nutrigenomics, epigenetics, gene expression, cell cycle, and lifespan nutrition. It includes a glossary, clinical correlates, diagrams, and a CD-ROM with additional material.

Carbohydrate-Active Enzymes: Stucture, Function and Applications is a comprehensive collection drawn from the proceedings of an international symposium held in Seoul, Korea. This text summarizes some of the most important research in the field of carbohydrate-active enzymes. Edited by a leading expert in the field, the book explores topics ranging from enzyme classification and structural elucidation to applications of enzymes in food processing and other industries. The coverage is divided into two distinct areas, the Structure-Function Relationship of Carbohydrate-Active Enzymes and Functions and Applications of Carbohydrate-Active Enzymes.

Catalog no. 55526, ISBN: 978-1-4200-5552-8 January 2009, 7 x 10, 552 pp., Soft Cover Suggested Price: $99.95 / £55.99

Catalog no. N10036, ISBN: 978-1-4398-0158-1 January 2009, 6 x 9, 312 pp. Suggested Price: $239.95 / £125.00

Seoul National University, Korea

Anti-Angiogenic Functional and Medicinal Foods Edited by

Jack N. Losso

Louisiana State University, Baton Rouge, USA

Fereidoon Shahidi

Carbohydrates in Food

Nutrition Science

University of Nebraska, Lincoln, USA

Second Edition

Memorial University of Newfoundland, Canada

Edited by

Debasis Bagchi

Ann-Charlotte Eliasson

Creighton University, Omaha, Nebraska, USA

Lund University, Sweden

Series: Nutraceutical Science and Technology

Series: Food Science and Technology

Drawing from an extensive list of esteemed international contributors, Anti-Angiogenic Functional and Medicinal Foods explores the history and scope of the use of functional foods around the world. It illustrates the importance of recent “ohmics” technology for understanding the molecular basis of nutrition and systems toxicology. Individual chapters explain the role of angiogenesis in various chronic diseases including tumors, cardiovascular disease, inflammatory arthritis, and obesity, and the text studies specific foods and their functional bioactive compounds. It concludes by considering the challenges faced during the development and delivery of anti-angiogenic functional food products.

Continuing in the tradition of its predecessor, the second edition of the popular Carbohydrates in Food offers comprehensive coverage of the chemical analysis, structure, functional properties, and nutritional relevance of monosaccharides, disaccharides, and polysaccharides used in food. It analyzes the significance of carbohydrates in diet using both chemical and biochemical methods. This edition includes updated information on nutritional, analytical, physicochemical, and functional aspects of mono- and disaccharides, gums/hydrocolloids, plant cell wall polysaccharides, and starch. The book also illustrates how carbohydrates are used in product development to increase health benefits.

Catalog no. DK3217, ISBN: 978-1-57444-445-2 2007, 6-1/8 x 9-1/4, 736 pp. Suggested Price: $185.95 / £103.00

Catalog no. DK3053, ISBN: 978-0-8247-5942-1 2006, 6 x 9, 560 pp. Suggested Price: $154.95 / £86.00

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CRC Desk Reference for Nutrition Second Edition

N.A. Michael Eskin

University of Manitoba, Winnipeg, Canada

Carolyn D. Berdanier

Snait Tamir

Series: Desk References

Series: Functional Foods and Nutraceuticals, 8

Thoroughly updated and expanded to reflect major advances over the past decade, the CRC Desk Reference for Nutrition concisely defines hundreds of terms used in nutrition science. This second edition also includes numerous additional terms and includes notable revisions along with new information that facilitates data accessibility; web addresses that provide access to the extensive Table of Food Composition maintained by the USDA and the Dietary Reference Intakes that contains the most current recommendations for nutrient intakes; and listings of the many drugs are used to manage nutrition-related conditions, such as cardiovascular disease, diabetes, hypertension, and obesity.

Health professionals recognize the role of nutraceuticals in health enhancement, however, there is much confusion and misinformation about these products and the science behind them. Dictionary of Nutraceuticals and Functional Foods is the first reference of its kind for this rapidly developing field. It provides concise, sciencebased information on over 470 nutraceutical and functional food products and compounds. Each entry lists the most current information on the product or compound, its role in the promotion of health or the prevention of disease, and peer-reviewed literature references. This reference also contains 172 chemical structures, 102 figures, 73 schemes, and 64 tables.

Catalog no. 3835, ISBN: 978-0-8493-3835-9 2006, 7 x 10, 536 pp. Suggested Price: $104.95 / £57.99

Catalog no. 1572, ISBN: 978-0-8493-1572-5 2006, 7 x 10, 520 pp. Suggested Price: $93.95 / £51.99

Delivery and Controlled Release of Bioactives in Foods and Nutraceuticals

Food Composition and Nutrition Tables

University of Georgia, Athens, USA

Nutrition Science 42

Dictionary of Nutraceuticals and Functional Foods

Edited by

Nissim Garti

The Hebrew University of Jerusalem, Israel

This important book reviews how to optimize delivery and controlled release systems to maximize the health-promoting properties of food products. It discusses factors affecting nutrient bioavailability and assessment methods, addresses materials and specific application techniques, and compares the benefits and drawbacks of structured lipids, micro- and nano-emulsions, food-protein-derived materials, complexes and conjugates of biopolymers, and starch. The book presents the differing parameters involved in controlled release of antioxidants, vitamins, folic acid, probiotics, fish oils, and proteins, as well as regulatory issues and future trends in bioactives and nutraceuticals. Catalog no. WP7436, ISBN: 978-1-4200-7436-9 2008, 6-1/8 x 9-1/4, 384 pp. Suggested Price: $279.95 / £147.00

Tel-Hai Academic College, Upper Galilee, Israel

7th Edition

Siegfried W. Souci, W Fachmann, and Heinrich Kraut Stuttgart, Germany

This updated edition presents the array of data needed for effective and accurate nutritional decisions in the production, marketing, and control of food products. The food composition and nutrition tables in this book, which are presented in English, German, and French, address varying nutritional requirements and allow for the constant changes in the nutritional assessment of food constituents. This seventh edition builds on the strong base of the previous volumes by incorporating new discussions on select foods, investigations in bioactive compounds, as well as additional and revised data on more than 800 foods and 300 constituents. Catalog no. V9178, ISBN: 978-0-8493-4141-0 2008, 8-1/2 x 11, 1300 pp. Suggested Price: $199.95

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

Chemistry, Nutrition, and Biotechnology, Third Edition Edited by

Handbook of Nutraceuticals and Functional Foods

Casimir C. Akoh

Second Edition

The University of Georgia, Athens, USA

Edited by

David B. Min

Robert E.C. Wildman

The Ohio State University, Columbus, USA

Pittsburgh, Pennsylvania, USA

Series: Food Science and Technology, 117

Series: Modern Nutrition, 33

Highlighting the role of dietary fats in foods, human health, and disease, the third edition of Food Lipids emphasizes lipids from the point of entry into the food supply. New chapters cover polyunsaturated lipid oxidation in aqueous systems, total antioxidant evaluation and synergism, tocopherol stability and prooxidant mechanisms of oxidized tocopherols in lipids, and the effects and mechanisms of minor compounds in oil on lipid oxidation. Addressing the chemistry of lipid and antioxidant reactions as well as applications in biotechnology, this edition presents an indepth discussion on lipid oxidation and antioxidants, with updated information and references throughout the text.

With contributions from a panel of leading international experts, the Handbook of Nutraceuticals and Functional Foods, Second Edition, provides a collection of the most current topics in nutraceuticals and functional foods. This edition features new and revised chapters, including the topics of vitamin E, nutritional supplements and inflammation, whey protein, cereals, beverages, and fruits. This authoritative guide serves as a comprehensive, allin-one reference source for professionals in food chemistry and engineering as well as nutritional, pharmaceutical, and biomedical science and makes an ideal text for students specializing in these fields.

Catalog no. 46632, ISBN: 978-1-4200-4663-2 2008, 7 x 10, 928 pp. Suggested Price: $239.95 / £133.00

Catalog no. 6409, ISBN: 978-0-8493-6409-9 2007, 7 x 10, 560 pp. Suggested Price: $164.95 / £92.00

Nutrition Science

Food Lipids

Handbook of Nutrition and Food Second Edition

Handbook of Dairy Foods and Nutrition Third Edition

Edited by

Carolyn D. Berdanier

University of Georgia, Athens, USA

Johanna Dwyer

Gregory D. Miller, Judith K. Jarvis, and Lois D. McBean

National Dairy Council, Rosemont, Illinois, USA Series: Modern Nutrition

Handbook of Dairy Foods and Nutrition, Third Edition examines the role of dairy products in diet and health, covering such areas as cardiovascular health, hypertension, and cancer, as well as bone and oral health. This edition features a new chapter on dairy foods and weight management. Other chapters address lactose digestion and the contribution of dairy foods to health throughout the lifecycle. All chapters contain updated or new data and references. With peer-reviewed chapters by nutrition and medical experts, this book remains the most authoritative reference on dairy and nutrition currently available. Catalog no. 2828, ISBN: 978-0-8493-2828-2 2007, 7 x 10, 432 pp. Suggested Price: $129.95 / £71.99

Tufts New England Medical Ctr, Boston, Massachusetts, USA

Elaine B. Feldman

Professor Emerita, Medical College of Georgia, Augusta, USA

Extensively revised and updated, the Handbook of Nutrition and Food, Second Edition covers basic nutrition concepts including food composition, labeling, and nutrient analysis systems. It explores the role of individual micronutrients, metabolic issues, and nutrient-nutrient interactions, and examines their effects on the body. Contributions from leading researchers address nutritional need throughout the lifecycle from pre-natal to old age, and discuss the nutritional evaluation and monitoring of specific age and cultural demographics. A considerable portion of the book details clinical nutrition and the prophylactic and therapeutic use of nutrition in a wide variety of disease circumstances. Catalog no. 9218, ISBN: 978-0-8493-9218-4 2008, 8-1/2 x 11, 1288 pp. Suggested Price: $299.95 / £167.00

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Handbook of Nutrition in the Aged Edited by

Health Benefits and Food Applications

Ronald Ross Watson

Edited by

Fourth Edition

University of Arizona, Tucson, USA

Nutrition Science 44

Handbook of Prebiotics and Probiotics Ingredients

Series: Modern Nutrition

Susan Sungsoo Cho

NutraSource Inc., Laurel, Maryland, USA

The Handbook of Nutrition in the Aged reviews health problems that occur in aging adults and the nutritional therapies to overcome them. This fourth edition features new sections on alcohol and beverages in health degradation as well as complementary and alternative medicines, including the use of antioxidants, botanicals, and marine oils. New chapters address arthritis, cognitive functioning, diabetes prevention, cancer, nutritional supplements in fracture care, and recent research on protein and vitamins intake. This text also provides new information on adequate diets for the aging, undernutrition, longevity, disease prevention, and nutritional supplements to improve quality of life.

While it is clear that the combination of pre- and probiotics promotes gastrointestinal health and immunity, it is crucial to find them fully compatible with the formulation, processing, packaging, and distribution of functional foods. These technical difficulties have slowed the progress toward functional foods that take advantage of the benefits of these factors in combination. This comprehensive handbook provides up-to-date biological and physiological research findings on various pre- and probiotic ingredients. International experts discuss safety regulations and a wide range of food applications. An appendix offers food labeling guidelines for global suppliers of these products.

Catalog no. 59718, ISBN: 978-1-4200-5971-7 January 2009, 7 x 10, 368 pp. Suggested Price: $129.95 / £72.99

Catalog no. 62131, ISBN: 978-1-4200-6213-7 May 2009, 6-1/8 x 9-1/4, 352 pp. Suggested Price: $159.95 / £97.00

Handbook of Prebiotics Edited by

Glenn R. Gibson

The University of Reading, UK

Marcel B. Roberfroid

Handbook of Vitamins Fourth Edition Edited by

Robert B. Rucker, Janos Zempleni, John W. Suttie, and Donald B. McCormick

Université Catholique de Louvain, Brussels, Belgium

Series: Clinical Nutrition in Health and Disease, 3

Presenting a balanced view of many different areas of the field, this handbook discusses the concept, definition and criteria for classification as prebiotics and describes their interactions with gut microbiota. Contributions discuss the biomechanics of prebiotics and their effects on immune status, serum lipid concentrations, mineral bioavailability, and satiety modulation. They consider the health implications of prebiotic intake such as reduced incidence of gastroenteritis and chronic pathogenic gut disorders. The book also explores the varying effects of prebiotics in different populations and age groups and describes potential food avenues and the safety implications for prebiotic use.

Thoroughly revised and updated, Handbook of Vitamins highlights the most recent research in vitamins and gene expression, vitamin-dependent genes, and vitamin effect on DNA stability. This fourth edition includes new chapters on vitamin-dependent modification of chromatin, analysis of vitamin metabolism using accelerated mass spectrometry, and dietary reference intakes for vitamins. It encompasses traditional and modern approaches, focusing on human nutrition, vitamin analysis, and vitamin action at the molecular level. Featuring contributions from international experts, this remains an ideal reference for nutritional scientists, food scientists, and graduate students.

Catalog no. 8171, ISBN: 978-0-8493-8171-3 2008, 6-1/8 x 9-1/4, 504 pp. Suggested Price: $149.95 / £83.00

Catalog no. 4022, ISBN: 978-0-8493-4022-2 2007, 7 x 10, 608 pp. Suggested Price: $154.95 / £86.00

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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Lipid Metabolism and Health

Textbook

Introducing Food Science

Edited by

Robert L. Shewfelt

Bryant Stamford

With a compelling new approach to introductory food science, this textbook is designed to excite and encourage students studying this topic. It proceeds from a non-technical discussion of food issues that concern today’s consumer to an in-depth technical overview of the basic principles of the study of food. The book dicusses commercial products and processes and explores the functions and roles of food scientists. Each section builds on the previous one, providing greater technical depth. Depending on the course, professors can choose to use select chapters or all chapters in the book. This volume provides a comprehensive introduction to food science for the major and non-major alike.

This book comprehensively explores the links between lipids and health. It offers an accessible background on basic lipodology and lipid measurement, including lipid/lipoprotein metabolism and the biology of atherosclerosis. It discusses medical conditions affected by lipids and lipoproteins, such as diabetes and metabolic syndromes. Several chapters are devoted to how lipoproteins are affected by lifestyle practices including diet, exercise, and tobacco use. This is the first text to address the prevention and treatment of lipoprotein abnormalities in a comprehensive way, and is an invaluable tool for nutrition scientists, researchers, and dieticians.

Florida State University, Tallahassee, USA Hanover College, Indiana, USA

Catalog no. TX285, ISBN: 978-1-58716-028-8 February 2009, 6-1/8 x 9-1/4, 352 pp. Suggested Price: $59.95 / £36.99

Nutrition Science

University of Georgia, Athens, USA

Robert J. Moffatt

Catalog no. 2680, ISBN: 978-0-8493-2680-6 2006, 6-1/8 x 9-1/4, 376 pp. Suggested Price: $134.95 / £74.99

Nutrients and Epigenetics

Textbook

Introduction to Nutrition and Metabolism

Edited by

Sang-Woon Choi

Fourth Edition

Jean Mayer USDA Human Nutrition Research Center on Aging

David A. Bender

Simonetta Friso

University College London, UK

University of Verona School of Medicine, Italy

This fourth edition of a bestseller has been thoroughly updated and provides a clear introduction to the science of nutrition and metabolism. Using basic biochemistry, it explains the scientific principles underlying our current understanding of the interactions between diet and health, examines nutrient function and metabolic pathways, and explores the scientific basis of dietary goals and recommendations. New features include a list of key points at the end of each chapter and the addition of open-ended case-based problems. The accompanying CD-ROM contains PowerPoint® presentations, self-assessment exercises, a virtual laboratory, and a nutrient analysis program.

Presenting up-to-date research on the relationship between nutrition and the evolving field of epigenetics, this work takes a close look at current findings and the potential impact of this research on our understanding of aging, embryonic growth, and the development of cancer. With the aid of numerous color illustrations and photographs, it effectively describes how nutrients modulate physiologic and pathologic processes. Providing a starting point for further research, it covers a range of cutting-edge topics that include current findings on DNA methylation, histone modification, and chromatin remodeling. It also details methods to measure epigenetic phenomena.

Catalog no. 43129, ISBN: 978-1-4200-4312-9 2008, 7 x 10, 440 pp., Soft Cover Suggested Price: $67.95 / £37.99

Catalog no. 63545, ISBN: 978-1-4200-6354-7 May 2009, 6-1/8 x 9-1/4, 240 pp. Suggested Price: $129.95 / £78.99

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For more information and a complete list Oxidative Stress and Inflammatory Mechanisms in Obesity, Diabetes, and the Metabolic Syndrome Edited by

Phytochemicals

Nutrient-Gene Interactions Edited by

Mark S. Meskin and Wayne R. Bidlack

Lester Packer

California State Polytechnic University, Pomona, USA

Helmut Sies

Access Business Group, Ada, Michigan, USA

University of Southern California, Los Angeles, USA

Nutrition Science

Heinrich-Heine-Universitaet, Dusseldorf, Germany

This groundbreaking work offers a comprehensive view of the different components of metabolic stress and its association with oxidative stress and inflammation. It reports on cutting-edge research on the intracellular events mediating or preventing oxidative stress and pro-inflammatory processes in obesity and type 2 diabetes. The book also addresses the molecular mechanisms inherent in the progression of metabolic stress and considers phenotypic perspectives, as well as dietary factors and micronutrients. This book encourages evidence-based nutritional and pharmacological therapies to attenuate the impact of obesity-induced insulin resistance and ensuing metabolic syndrome. Catalog no. 43781, ISBN: 978-1-4200-4378-5 2008, 6 x 9, 344 pp. Suggested Price: $164.95 / £92.00

R. Keith Randolph

This book analyzes the mechanisms of action and impact of phytochemical-gene interactions on health, aging, and disease. It covers experimental methodologies for identifying significant interactions between diet, genetic variants, and different markers of cardiovascular disease, inflammation, and obesity. It examines the role of resveratrol in cardiovascular health; the preventative mechanisms of whole grains and omega-3 fatty acids; epidemiological research on plant-based foods; the non-antioxidant cellular properties of vitamin E; and controlled clinical trials. It also explores the role of nutrigenomics in developing safe and effective phytochemical products. Catalog no. 4180, ISBN: 978-0-8493-4180-9 2006, 6-1/8 x 9-1/4, 232 pp. Suggested Price: $144.95 / £79.99

Phytochemicals Aging and Health Edited by

46 Mark S. Meskin and Wayne R. Bidlack

California State Polytechnic University, Pomona, USA

R. Keith Randolph

Access Business Group, Alda, Michigan USA

With the increase in the aging population, researchers are focusing on the role of nutrition, plant-based diets, and phytochemicals in healthy aging. This volume illustrates the role of phytochemicals in disease prevention, providing an understanding of their relationship to healthy aging in an effort to promote optimal health and disease prevention. This text presents information on polyphenols, flavonoid analysis, botanical therapeutics and chronic disease prevention, carotenoids and visual function, green tea and skin care, pomegranate and cardiovascular disease, nutrient-gene interactions, and personalized nutrition, with a focus on nutrigenetics as a means of nutrition therapy. Catalog no. 61372, ISBN: 978-1-4200-6137-6 2008, 6-1/8 x 9-1/4, 232 pp. Suggested Price: $129.95 / £72.99

Phytochemicals in Nutrition and Health Edited by

Mark S. Meskin, Wayne R. Bidlack, and Audra J. Davies, and Stanley T. Omaye Supported by solid scientific research, Phytochemicals in Nutrition and Health explores the mechanisms of action associated with beneficial phytochemical groups. This volume examines new areas such as the efficacy and safety of medicinal herbs, the use of biotechnology to manipulate and enhance the phytochemical profiles of various plants, and the pharmacokinetics of phytochemicals in humans. The editors of this authoritative resource also explore new research on phytochemicals in the Vaccinium family (cranberries, blueberries and bilberries), wine, and oilseeds, as well as the biological activity of Echinacea in humans. Catalog no. TX838, ISBN: 978-1-58716-083-7 2002, 6-1/8 x 9-1/4, 224 pp. Suggested Price: $144.95 / £79.99

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Vitamin Analysis for the Health and Food Sciences Second Edition Lin Ye

Analysis, Bioavailability, and Stability

W.O. Landen, Jr

George F.M. Ball

The University of Georgia, Athens, USA The Coca-Cola Company, Atlanta, Georgia, USA Consultant, Lavonia, Georgia, USA

Series: Food Science and Technology, 156

Employing a uniform, easy-to-use format, this second edition explores methods of vitamin analysis applicable to foods, supplements, and pharmaceuticals. Highlighting the rapid advancement of vitamin assay methodology, the book emphasizes the use of improved and sophisticated instrumentation including the widely adopted LC-MS. Designed as a bench reference, this volume covers basic chemistry and biochemistry and discusses available analytical methods, emphasizing regulatory methods and advanced methods of current significance. It also supplies insight into practical problem solving involving the stability of vitamins and their extraction from different biological matrices.

Vitamins in Foods: Analysis, Bioavailability, and Stability presents information on vitamin chemistry, absorption, and metabolism. The first of two sections discusses the effects of food processing on vitamin retention, the physiology of vitamin absorption, and the physiochemical properties of individual vitamins. Factors affecting vitamin bioavailability are also discussed in detail including the development of suitable analytical methods. The second section describes the principles of analytical methods and provides detailed methods for depicting individual vitamins in foods. It includes discussion of vitamin stability from post-harvest handling to meal preparation.

Catalog no. 9771, ISBN: 978-0-8493-9771-4 2008, 7 x 10, 664 pp. Suggested Price: $154.95 / £86.00

Catalog no. DK4945, ISBN: 978-1-57444-804-7 2006, 6 x 9, 824 pp. Suggested Price: $209.95 / £117.00

Vitamin K in Health and Disease

Advances in Conjugated Linoleic Acid Research

Volume 3

Professor Emeritus, University of WisconsinMadison, USA

Martin P. Yurawecz, John K.G. Kramer, Ola Gudmundsen, Michael W. Pariza, and Sebastiano Banni

Studied since the 1930s, Vitamin K is a fat-soluble vitamin available from vegetable and animal sources. Vitamin K in Health and Disease provides a comprehensive summary of the latest scientific evidence regarding Vitamin K’s health-promoting activities. This book offers complete coverage of the chemistry of Vitamin K, deficiency signs and nutritional assessment, metabolism and biochemistry, and pharmacology. It presents up-to-date scientific studies on the nutritional, metabolic, and medical aspects along with an overview of the history of Vitamin K research. This text also reviews current dietary requirements and discusses both plasma and non-plasma Vitamin K-dependent proteins.

Interest in the chemistry, biological properties and health benefits of conjugated linoleic acid (CLA) continues to grow. The number of peer-reviewed publications produced on CLA since the 2003 publication of Advances in Conjugated Linoleic Acid Research, Volume 2 has more than doubled. It is likely that CLA will be used in the future in many more studies related to diseases such as cancer, atherosclerosis, and diabetes. This text provides comprehensive coverage of this area of research. Sections include material on biosynthesis and metabolic processes, techniques of determination of individual isomers, diversity of CLA, and the effects of CLA isomers in humans.

Catalog no. 3392, ISBN: 978-0-8493-3392-7 April 2009, 6-1/8 x 9-1/4, 328 pp. Suggested Price: $129.95 / £78.99

Catalog no. AO9787, ISBN: 978-1-893997-87-5 2007, 256 pp., Soft Cover Suggested Price: $124.95 / £69.99

John W. Suttie

Nutrition Science / Biochemistry

Vitamins in Foods

Ronald R. Eitenmiller

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Application of Solution Protein Chemistry to Biotechnology

Biochemistry and Molecular Biology Compendium

Roger L. Lundblad

Relying upon his broad view of biotechnology, pioneering scientist Roger Lundblad draws from both traditional protein science and proteomics to include a great deal of material not found in electronic format. He includes chapters on the use of classical protein chemistry in food, the protein and carbohydrate chemistry of adhesives, glues and sealants, protein chemistry and hydrogels, and the use of chemical modification to prepare protein therapeutics. While demonstrating current use and the development of biotech applications, the book separates what is truly new from that which has merely been renamed, providing time-saving research on which others can build.

This unique compendium provides researchers with a range of information not found in more database-oriented resources. The renowned author provides a list of acronyms with definitions, as well as a glossary for systems and techniques used in biochemistry, molecular biology, biotechnology, proteomics, genomics, and systems biology. Coverage also includes analytical procedures and chemicals commonly employed in biochemistry and molecular biology, complete with properties and structure drawings. It also provides listings of protease inhibitors, Log P values, water solubility, organic name reactions, and buffers with references to specific uses.

Lundblad Biotechnology, Chapel Hill, North Carolina, USA

Biochemistry

Catalog no. 73419, ISBN: 978-1-4200-7341-6 April 2009, 6-1/8 x 9-1/4, 576 pp. Suggested Price: $169.95 / £103.00

Lundblad Biotechnology, Chapel Hill, North Carolina, USA

Catalog no. 43471, ISBN: 978-1-4200-4347-1 2007, 7 x 10, 424 pp. Suggested Price: $104.95 / £57.99

Bioactive Natural Products

Detection, Isolation, and Structural Determination, Second Edition Edited by

Steven M. Colegate

CSIRO/Plant Toxins Unit, Division of Animal Healt, Geelong, Australia

Russell J. Molyneux

Biomolecular EPR Spectroscopy

Western Regional Research Center, Albany, California, USA

Wilfred Raymond Hagen

Following the successful format of its predecessor, this second edition presents applications of the most recent techniques for the detection, isolation, and structural determination of bioactive natural products. This edition features new case studies and illustrations that demonstrate practical applications of techniques covered in the book. The text includes updates on bioactive chemical extraction and NMR-based structure determination, along with new contributions on liquid chromatography linked with mass spectrometry and NMR spectroscopy, dereplication approaches, assessment of source material for bioactive natural products, and novel bioassay development.

Biomolecular EPR spectroscopy is widely used for the structural, functional, and analytical analysis of paramagnetic molecules in the biochemistry of all species and in related fields. This volume presents comprehensive, up-to-date coverage of the theory of spectroscopy and its applications to biological systems. The underlying quantum mechanics is introduced, assuming no previous knowledge but offering rigorous treatment. The author provides practical tricks as well as do’s and don’ts based on his 30 years of experience in the field. The text also includes supporting software with simple graphical user interfaces to allow readers to tackle most of the problems faced in spectral analysis.

Catalog no. 7258, ISBN: 978-0-8493-7258-2 2008, 7 x 10, 624 pp. Suggested Price: $209.95 / £117.00

Catalog no. 59572, ISBN: 978-1-4200-5957-1 January 2009, 6-1/8 x 9-1/4, 248 pp. Suggested Price: $139.95 / £77.99

Delft University of Technology, The Netherlands

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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Cancer and the Search for Selective Biochemical Inhibitors Second Edition

The Chemical Components of Tobacco and Tobacco Smoke Alan Rodgman

Winston-Salem, North Carolina, USA

Thomas A. Perfetti

Perfetti and Perfetti, LLC, Winston-Salem, North Carolina, USA

E.J. Hoffman

Catalog no. 45938, ISBN: 978-1-4200-4593-2 2007, 6-1/8 x 9-1/4, 480 pp. Suggested Price: $149.95 / £86.00

Cataloging over 8400 tobacco and tobacco smoke components, this book provides the most comprehensive, single-source reference published on the subject since 1968. It reviews every chemical class of components found in tobacco and tobacco smoke and presents more than 6000 cited references that deal with many topics pertinent to the components in question. The authors list the corresponding Chemical Abstracts Registry Number for most cataloged components. They also examine adverse healthrelated problems assigned to specific tobacco smoke components and the components reported to negate such harmful effects. The accompanying CD-ROM contains a searchable, 300-page alphabetical component index.

Biochemistry

Laramie, Wyoming, USA

Elucidating the underlying biochemical principles for alternative cancer therapies, this second edition of a bestseller discusses complementary, alternative, and integrative treatments in comparison to chemotherapy. It examines the link between concepts and practices of alternative and conventional medicine. The author analyzes the activity of anticancer plant substances and other alternatives such as Vitamin C, essiac tea, shark cartilage, and cat’s claw. The text also addresses the problem of determining selective and non-toxic enzyme inhibitors for cancer cell metabolic pathways, an area of research in which new developments have given renewed hope to cancer patients.

Catalog no. 78836, ISBN: 978-1-4200-7883-1 January 2009, 8-1/2 x 11, 928 pp. Suggested Price: $299.95 / £167.00

Textbook

Carotenoids

Physical, Chemical, and Biological Functions and Properties Edited by

Chemistry for the Life Sciences

Second Edition

Raul Sutton and Peter G. Swindells University of Wolverhampton, UK

John T. Landrum

Bernard Rockett

Florida International University, Miami, USA

Formerly of University of Wolverhampton, UK

Carotenoids are of great interest due to their essential biological functions in both plants and animals. However, the properties and functions of carotenoids in natural systems are surprisingly complex. With an emphasis on the chemical aspects of these compounds, Carotenoids: Physical, Chemical, and Biological Functions and Properties presents a broad overview and recent developments on carotenoid structure, electronic and photochemical properties, and the use of novel analytical methods in the detection and characterization of carotenoids and their actions. The text also explores LC/MS and LC/MS/MS techniques as well as new applications of PCR and molecular biology methodologies.

Retaining the user-friendly style that made the original popular, this updated edition continues to provide a foundation in the aspects of chemistry that developing life scientists need in order to understand biochemical and biomedical research. This edition adds new chapters, including one on water, covering the mole concept and colloids; another on gases, discussing pressure, solubility, and diffusion; and still another chapter on metals, examining properties, carriers, biocatalysis, and toxicity. Critical information is reinforced through worked examples and questions, and a solutions manual is available for qualifying instructors.

Catalog no. 52306, ISBN: 978-1-4200-5230-5 July 2009, 7 x 10, 1184 pp. Suggested Price: $215.95 / £131.00

Catalog no. 69357, ISBN: 978-1-4200-6935-8 January 2009, 7 x 10, 280 pp., Soft Cover Suggested Price: $39.95 / £22.99

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For more information and a complete list Chemistry of Natural Products Amino Acids, Peptides, Proteins, and Enzymes

Indira Gandhi National Open University, New Delhi, India

Comprehensive Handbook of Chemical Bond Energies

Sanjiv Kumar

Yu-Ran Luo

An authoritative text covering different areas of natural product chemistry, this volume offers detailed, individual chapters on the chemistry of amino acids, peptides, proteins and enzymes. The book covers nomenclature, classification, stereochemistry, physical and chemical properties, and synthesis and reaction mechanisms, along with industrial applications for each item. Topics include the formation of peptide bonds, peptide synthesis, and the structure and functions of biologically important peptides. Comprensive in scope, the book also discusses the structural determination of proteins, the mode of action of enzymes, and the structure and function of different coenzymes.

Drawn from over 5,500 sources, the Comprehensive Handbook of Chemical Bond Energies compiles the most recent experimental BDE data for more than 19,600 bonds and 102 elements. Organized by bond type, functional group, bond order, bond degree, molecular size, and structure, the data can also be located using the Periodic Table. The book presents data for organics, biochemicals, and radicals as well as clusters, ions, hydrogen- and surface-bonded species, Van der Waals complexes, and halogen-clusters/complexes. It also introduces entirely new data for inorganics and organometallics and summarizes the heats of formation for atoms, free radicals, and monoatomic ions in the gas phase.

Catalog no. AB5917, ISBN: 978-1-4200-5917-5 2007, 6 x 9, 224 pp. Suggested Price: $73.95 / £40.99

Catalog no. 7366, ISBN: 978-0-8493-7366-4 2007, 7 x 10, 1688 pp. Suggested Price: $450.00 / £250.00

V. K. Ahluwalia

University of Delhi, India

Lalita S. Kumar

Deshbandhu College, University of Delhi, India

University of Science and Technology of China

Biochemistry

Copper Amine Oxidases

Structures, Catalytic Mechanisms and Role in Pathophysiology

Chemistry of Peptide Synthesis

Edited by

N. Leo Benoiton

Bruno Mondovi

This book is a complete overview of how peptides are synthesized and what techniques yield the most desirable reactions, encompassing all factors affecting synthesis and peptide formation. Developed from the author’s extensive teaching career, the book emphasizes learning rather than memorization. Topics include stereomutation, the applicability of coupling reactions, solid-phase synthesis, protection of functional groups, aminolysis, acidolysis, and the use of scavengers. It uses clear language and schematics to present concepts methodically and progressively, from basic theory that can be approached by non-chemists to in-depth coverage that can be appreciated by experienced peptidologists.

Although the amount of research on copper amine oxidases has grown rapidly and substantially in the past decade, the field unfortunately suffers from lack of cohesion and significant confusion surrounds aspects as simple as confirmation of enzyme identities. This book describes the structure of the enzymes, the role of copper, and of the unusual cofactor 6-hydroxydopa quinine derived from a posttranslational modification of a tyrosine residue. It also covers the differences in amine oxidases from bacteria, plants, and mammals. Finally, the text examines the importance of this ubiquitous class of enzymes in physiology and in metabolism of biogenic amines.

Ottawa, Ontario, Canada

Catalog no. DK3236, ISBN: 978-1-57444-454-4 2006, 6-1/8 x 9-1/4, 304 pp. Suggested Price: $154.95 / £86.00

Giovanni Floris

University of Cagliari, Monserrato (CA), Italy University of Rome, La Sapienza, Italy

Catalog no. 76809, ISBN: 978-1-4200-7680-6 February 2009, 6-1/8 x 9-1/4, 280 pp. Suggested Price: $149.95 / £89.00

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CRC Handbook of Chemistry and Physics 90th Edition

Design of Caspase Inhibitors as Potential Clinical Agents Edited by

Tom O’Brien

Sunesis Pharmaeuticals, San Francisco, California, USA

Steven D. Linton

National Institute of Standards & Technology (Retired), Gaithersburg, Maryland, USA

San Diego, California, USA

Mirroring the growth and direction of science for nearly a century, the CRC Handbook of Chemistry and Physics, now in its 90th edition, adds several new tables that will be among the most accessed in the world. These include Structure and Functions of Common Drugs, Solubility Parameters of Polymers, Major World Earthquakes, and Equilibrium Constants of Selected Enzyme Reactions. It adds major updates to several more, including Threshold Limits for Airborne Contaminants, Mass Spectral Peaks of Common Organic Solvents, and Properties of the Solar System. Also included is a table of the Handbook’s greatest fans: Nobel Laureates in Chemistry and Physics.

Caspases (cysteine aspartyl proteases) represent one of the most specific protease families described to date. As caspase family members are involved in pro-inflammatory responses, inhibition of caspase activity represents a novel yet core approach to disease treatment. Design of Caspase Inhibitors as Potential Clinical Agents discusses the role of caspases in inducing cell death. It reviews recent efforts to develop small molecule inhibitors that are capable of modulating caspase activity. The text also examines the difficulties encountered in transitioning small molecule inhibitors from the lab to clinical use, and discusses how these challenges can best be overcome to allow continued progress.

Catalog no. 90844, ISBN: 978-1-4200-9084-0 June 2009, 8-1/2 x 11, 2700 pp. Suggested Price: $149.95 / £89.00 Also available as a CD and in a web version

Cyclic Nucleotide Phosphodiesterases in Health and Disease Edited by

Joseph A. Beavo

University of Washington, Seattle, USA

Sharron H. Francis

Vanderbilt University School of Medicine, Nashville, Tennessee, USA

Enzyme Inhibitors Series

Catalog no. 45407, ISBN: 978-1-4200-4540-6 January 2009, 6-1/8 x 9-1/4, 312 pp. Suggested Price: $169.95 / £94.00

Dictionary of Carbohydrates with CD-ROM

Second Edition Edited by

Miles D. Houslay

Peter M. Collins

University of Glasgow, Scotland

Birkbeck College, London, UK

Presenting a modern, comprehensive reference book on cyclic nucleotide phosophodiesterases (PDE), this text appeals to scientists in academia, the pharmaceutical industry, and related clinical disciplines. In the last 15 years, information relating to PDE genetics, physiological functions, roles in disease states, regulation, structure and interaction with pharmacologically active agents has burgeoned. This book covers the current information and its potential for future development. It describes the fundamental biochemical features of each of the known PDE families and the advances being made in developing selective inhibitors for these various enzymes.

The new edition of this authoritative reference includes 3000 new compounds, bringing the total to 26,000. All existing entries have been carefully reviewed and updated where necessary. The data included in each entry includes chemical names and synonyms, including CAS and IUPAC names, trade names, and trivial names; full and clear description of equilibrium studies, cyclic forms, and their derivatives; extensive occurrence and use data; structure diagrams showing stereochemistry and configuration; and physical properties including melting point, optical rotation, and mutarotation data. This edition also features a structure-searchable CD-ROM providing quick, convenient access.

Catalog no. DK9668, ISBN: 978-0-8493-9668-7 2007, 7 x 10, 728 pp. Suggested Price: $209.95 / £117.00

Biochemistry

David R. Lide

Catalog no. 3829, ISBN: 978-0-8493-3829-8 2006, 8-1/2 x 11, 1304 pp. Suggested Price: $519.00 / £288.00

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For more information and a complete list Encyclopedia of Supramolecular Chemistry Edited by

Jerry L. Atwood

University of Missouri, Columbia, Missouri, USA

Jonathan W. Steed

Biochemistry 52

Textbook

Fundamentals of Biochemical Calculations Second Edition Krish Moorthy

University of Durham, UK

Formerly of RMIT University, Melbourne, Australia

The two-volume Encyclopedia of Supramolecular Chemistry offers authoritative, centralized information on crystallizing, a rapidly expanding interdisciplinary field. In this comprehensive text, user-friendly and high-quality articles parse the latest supramolecular advancements and methods in the areas of chemistry, biochemistry, biology, environmental and materials science and engineering, physics, computer science, and applied mathematics. Designed for specialists and students alike, the two-volume set covers the fundamentals of supramolecular chemistry and sets the standard for relevant future research.

Drawing attention to the widely applicable Ratio method for performing biochemical calculations, this fully updated text encourages scientists to learn, rather than memorize, the processes involved by developing their mathematical logic and problem solving skills. The book’s user-friendly style requires no advanced knowledge of mathematics. Featuring new solved problems, useful comments, and mathematical hints, this edition also introduces three new chapters on calculations related to experimental biochemistry, molecular biology, and pharmacy. It also includes a supplementary CD-ROM with additional questions and answers.

Catalog no. DK056X, ISBN: 978-0-8247-5056-5 2004, 8-1/2 x 11, 1744 pp. Suggested Price: $560.00 / £311.00

Catalog no. 53574, ISBN: 978-1-4200-5357-9 2008, 7 x 10, 192 pp., Soft Cover Suggested Price: $41.95 / £22.99

Endocrine Disruption Modeling Edited by

James Devillers

Handbook of Capillary and Microchip Electrophoresis and Associated Microtechniques Third Edition

CTIS, Rillieux La Pape, France

Edited by

Series: QSAR in Environmental and Health Sciences

James P. Landers

Based on the research of an international panel of contributors from industry, academia, and regulatory agencies, this book provides an excellent overview of current approaches for modeling the endocrine activity of chemicals and the related potential adverse effects they may induce on environmental and human health. It focuses on chemicals accidentally released into the environment and also on the specific design of chemicals acting on the endocrine system of insects. An interesting feature of the book is the uniting of these two aspects of endocrine disruption, which are based on the same modeling concepts. It also includes a review of the available e-resources in this field.

Now in its third edition, this best-selling work continues to offer state-of-the-art information on the development and employment of capillary electrophoresis. With special emphasis on microseparations and microfluidics, it features new chapters describing the use of microchip electrophoresis and associated microtechniques, with a focus on the extraordinary breadth of work undertaken to expand CE methodologies in recent years. Enhanced by contributions from leading international experts, the Handbook of Capillary and Microchip Electrophoresis and Associated Microtechniques, Third Edition remains a seminal reference for the chemistry, biology, and engineering fields.

Catalog no. 76353, ISBN: 978-1-4200-7635-6 March 2009, 6-1/8 x 9-1/4, 424 pp. Suggested Price: $139.95 / £85.00

Catalog no. 3329, ISBN: 978-0-8493-3329-3 2008, 7 x 10, 1592 pp. Suggested Price: $209.95 / £117.00

University of Virginia, Charlottesville, USA

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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Hansen Solubility Parameters A User’s Handbook, Second Edition

Textbook

Insect Physiology and Biochemistry Second Edition

Charles M. Hansen Consulting, Hoersholm, Denmark

James L. Nation

In this new edition, Charles M. Hansen invites five renowned experts to share their innovative work on novel topics such as using statistical thermodynamics to confirm existing HSPs, reconciling HSP with other thermodynamic theories, predicting the behavior of carbon dioxide, environmental stress cracking, and absorption and diffusion in polymers. It also provides insight on future applications in biological materials, controlled release, nanotechnology, and selfassembly. The book highlights recent findings on interactions with DNA, and other novel applications of HSPs, such as ozone-safe solvents, protective clothing, drug delivery systems, and petroleum applications.

This new edition of a best-selling text presents new findings that challenge the conventional wisdom and considers their impact on not just the field of entomology, but also across species. It features new chapters on insect immunity, insect flight, insect vision, and diapause in insects, and includes updated and additional information on insect hormones and development. Providing a clear description of the principles, fundamentals, and terminology of insect physiology, this comprehensive resource offers an indepth discussion of the relationship between insect physiology and animal behavior and ecology. This volume contains more than 2000 updated references and new color illustrations.

Catalog no. 7248, ISBN: 978-0-8493-7248-3 2007, 7 x 10, 544 pp. Suggested Price: $164.95 / £92.00

Catalog no. 61771, ISBN: 978-1-4200-6177-2 2008, 7 x 10, 560 pp. Suggested Price: $79.95 / £44.99

Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents

Textbook

Edited by

Paul J. Smith

Cardiff University, UK

Eddy W. Yue

Incyte Corporation, Wilmington, Delaware, USA Series: Enzyme Inhibitors Series, 3

One of few books to cover all aspects of cyclin-dependent kinases (CDKs), this volume examines CDKs as molecular and functional entities, their role in various disease processes, and their potential for pharmacological modulation. The book first explains the integration of cell cycle control pathways, opportunities for targeting, targets of inhibitors, and the evaluation of CDK inhibitors. Then it examines the design, development, and chemistry of small molecule CDK inhibitors. The final section assesses the current status of CDK inhibitors in clinical trials, the therapeutic deployment challenges of small molecule inhibitors, and the future prospects of CDK inhibitors as anticancer agents. Catalog no. 3774, ISBN: 978-0-8493-3774-1 2007, 6-1/8 x 9-1/4, 448 pp. Suggested Price: $175.95 / £98.00

University of Florida, Gainesville, Florida, USA

Introduction to Peptides and Proteins

Biochemistry

Charles M. Hansen

Ulo Langel, Tamas Bartfai, Benjamin F. Cravatt, Nils Arne Elofsson, Astrid Graslund, N.G.H. von Heijne, and Matjaz Zorko Authored by key players in the field, this volume offers a relevant presentation of peptide and protein chemistry. It provides key insight into the fast-developing field of proteomics, including structural and functional aspects, biochip development, and clinical potential. The authors present the latest information on concerns over protein degradation as well as the post-translational modifications of proteins and peptides. The book also includes a section on protein-coupled diseases that presents increasing evidence of the impact of protein misfolding and various deviations in neurodegenerative diseases. It also examines the role of proteins in cancer. Catalog no. 64126, ISBN: 978-1-4200-6412-4 June 2009, 7 x 10, 560 pp. Suggested Price: $99.95 / £60.99

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For more information and a complete list

Ion-Radical Organic Chemistry

Principles and Applications, Second Edition Zory Vlad Todres

The Organic Chemistry of Sugars Edited by

Daniel E. Levy

Scios, Fremont, California, USA

Biochemistry

American Chemical Society, Columbus, Ohio, USA

Péter Fügedi

Consolidating knowledge from a number of disciplines, this treatise presents the recent changes that have occurred in the field since the publication of the first edition. Avoiding complex mathematics, the book explains the principles of ion-radical organic chemistry and presents an overview of organic ion-radical reactions. Methods of determining ion-radical mechanisms and controlling ion-radical reactions are also reviewed. Wherever applicable, issues relating to ecology and biomedical concerns are addressed, and inorganic participants of the ion-radical organic reactions are also considered. The book concludes with practical applications and a future outlook.

Intrigued as much by its complex nature as by its outsider status in traditional organic chemistry, the editors of the critically acclaimed The Organic Chemistry of Sugars compile a groundbreaking resource in carbohydrate and sugar chemistry that illustrates the ease with which sugars can be manipulated in a variety of organic reactions. Presenting the organic chemistry of sugars as a solution to many complex synthetic challenges, the book focuses on reactions, including the substitution of sugar hydroxyl groups, chiral catalysis, and the syntheses of monosaccharides. It also covers the latest concepts in combinatorial carbohydrate chemistry, glycopeptides, and glycomimetics.

Catalog no. 9068, ISBN: 978-0-8493-9068-5 January 2009, 7 x 10, 496 pp. Suggested Price: $189.95 / £106.00

Catalog no. DK3103, ISBN: 978-0-8247-5355-9 2006, 7 x 10, 904 pp. Suggested Price: $209.95 / £117.00

Hungarian Academy of Sciences, Budapest

Lipoic Acid

Energy Production, Antioxidant Activity and Health Effects Edited by

54 Mulchand S. Patel

University at Buffalo, The State University of New York, USA

Lester Packer

University of Southern California, Los Angeles, USA

Practical Handbook of Biochemistry and Molecular Biology

Second Edition, CD-ROM Roger L. Lundblad

Series: Oxidative Stress and Disease

Lundblad Biotechnology, Chapel Hill, North Carolina, USA

Unique in its two-fold protective function, alpha-lipoic acid has drawn unprecedented interest for its role as a coenzyme in mitochondrial energy metabolism and as an antioxidant and cell redox modulator. This book covers the latest discoveries in the chemistry, biological action, and significance of alpha-lipoic acid in energy production, antioxidant activity, and health. First, it reviews the discovery, molecular structure, biosynthesis, and characterization of lipoic acid. Then it describes metabolic aspects and human pharmacodynamics. Finally, the book discusses clinical aspects and the treatment of metabolic syndrome, along with the loss of mitochondrial function and lipoic acid supplementation.

Presented in a concise, logical, and easy-to-follow format, the revised and expanded second edition of the Practical Handbook of Biochemistry and Molecular Biology provides essential reference information that cannot be easily obtained from another single source. This new edition features all information on CD-ROM to offer even faster and more convenient access to the most important topics that are relevant to each reader’s needs. With physical and chemical data, this updated disk offers complete coverage of proteins, nucleic acids, lipids, carbohydrates, amino acids, peptides, vitamins, proteomics, genomics, as well as cell biology, among other critical topics.

Catalog no. 45377, ISBN: 978-1-4200-4537-6 2008, 8-1/2 x 11, 556 pp. Suggested Price: $169.95 / £94.00

Catalog no. 8744, ISBN: 978-0-8493-8744-9 June 2009, CD-ROM Suggested Price: $199.95 / £121.00

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Textbook

Principles and Practice of Bioanalysis Second Edition

Surfactants in Personal Care Products and Decorative Cosmetics Third Edition Edited by

Richard F. Venn

Pfizer Central Research, Kent, UK

Series: Surfactant Science, 135

Principles and Practice of Bioanalysis, Second Edition provides an updated guide to the techniques currently used in developing and running ultra-trace analyses for drugs, metabolites and other substances. Extensively revised, this volume reflects the dynamic growth in methodologies that has occurred over the past five years. Experts in the field offer a logical path through the problems of small molecule bioanalysis, enabling researchers to choose the appropriate methods of analysis across a number of fields, including the agrochemical and pharmaceutical industries. Scientists and graduate students in biology, biochemistry, and chemistry will also find this to be a valuable reference.

This book provides the scientific basis necessary for understanding, formulating, and testing surfactant-based personal care products, cosmetics, and cosmeceuticals. The new edition re-examines the function of emulsions, microemulsions, micelles, and nanostructures in formulation and delivery. It presents the latest noninvasive in vivo and in vitro methods for verifying product benefit claims, optimal formulation strategies using specific surfactant raw materials for enhancing pigmented products, and ways to assess the effectiveness of UV sunscreens and self-tanners. Coverage includes surfactant solutions, cleanser/conditioner systems, pigment dispersions, and finished products.

Catalog no. 3857, ISBN: 978-0-8493-3857-1 2008, 7 x 10, 344 pp. Suggested Price: $89.95 / £49.99

Catalog no. DK3394, ISBN: 978-1-57444-531-2 2007, 6 x 9, 504 pp. Suggested Price: $199.95 / £109.00

Protein Misfolding in Neurodegenerative Diseases

Thin Layer Chromatography in Chiral Separations and Analysis

Mechanisms and Therapeutic Strategies Edited by

Edited by

Biochemistry

Linda D. Rhein, Mitchell Schlossman, Anthony O’Lenick, and P. Somasundaran

Edited by

Teresa Kowalska

H. John Smith, Claire Simons, and Robert D.E. Sewell

University of Silesia, Katowice, Poland

Cardiff University, UK

Lafayette College, Easton, Pennsylvania, USA

Enzyme Inhibitors Series

Chromatographic Science Series

Current research suggests that neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s, and Creutzfeldt-Jacob’s may be linked to disorders in protein shape referred to as “protein misfolding.” Continued study in this area could lead to promising advances in future treatment of these diseases. This groundbreaking text describes the latest findings regarding protein misfolding in the context of it being a marker, and perhaps a cause, in neurodegenerative diseases. Comprehensive coverage includes the diverse biochemical targets/markers for each disease, the currently limited success of drug therapies, and the cutting-edge research that could lead to potentially more promising treatments.

Thin Layer Chromatography in Chiral Separations and Analysis is the first book to focus solely on the theory, capabilities, and applications of TLC for direct and indirect enantioseparations. The first part of the book examines the fundamental principles of chirality and TLC. It describes the necessary materials, laboratory equipment, procedures, and strategies for the separation, quantification, isolation, and analysis of chiral compounds. Emphasizing pharmaceutical applications, the second part evaluates the real-world enantioseparations and densitometric analyses. Topics include chiral separation mechanisms, analyzing chiral purity, chiral stationary phases, and chiral modifiers of mobile phases.

Catalog no. 7310, ISBN: 978-0-8493-7310-7 2008, 6-1/8 x 9-1/4, 592 pp. Suggested Price: $164.95 / £92.00

Catalog no. 4369, ISBN: 978-0-8493-4369-8 2007, 6 x 9, 436 pp. Suggested Price: $175.95 / £98.00

Joseph Sherma

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For more information and a complete list

Water and Life Biochemistry / Biomaterials & Medical Devices

The Unique Properties of H20

Two-Dimensional Optical Spectroscopy Minhaeng Cho

Edited by

Ruth M. Lynden-Bell, Simon Conway Morris, John D. Barrow, John L. Finney, and Charles Harper

Korea University, Seoul, South Korea

Effectively introducing the newly-developed and exciting research field of two-dimensional optical spectroscopy, this volume offers valuable information on applying spectroscopic techniques to a wide range of problems in physical chemistry, biophysics, and biochemistry. The book touches on two of the most thrilling techniques and one of the most exciting developments in recent history: 2D IR and 2D electronic spectroscopies, providing the many researchers moving into the field every year with the first authoritative reference on this subject. It presents readers with detailed theoretical and experimental techniques that are currently being explored by researchers. Catalog no. 84291, ISBN: 978-1-4200-8429-0 April 2009, 6-1/8 x 9-1/4, 304 pp. Suggested Price: $139.95 / £85.00

Searching beyond our planet, scientists have focused on the idea that evidence of water is evidence of life. However, even if one believes that life is impossible without water, one should consider whether other forms of life may be possible where some variation of water exists. Taking nothing for granted, this volume brings together great thinkers from across disciplines who discuss whether or not the physiochemical properties of water are biocentrically “fine-tuned” for the existence and evolution of life. Exceptionally rigorous in its approach, this book lays a foundation for exploring some of the deepest quandaries in biochemistry. Catalog no. K10200, ISBN: 978-1-4398-0356-1 July 2009, 6 x 9, 400 pp. Suggested Price: $89.95 / £54.99

Vanadium

Chemistry, Biochemistry, Pharmacology and Practical Applications 56

Alan S. Tracey

Artificial Muscles

Applications of Advanced Polymeric Nanocomposites

Simon Fraser University,(Retired) Burnaby, British Columbia,

Mohsen Shahinpoor

Gail R. Willsky and Esther S. Takeuchi

Kwang J. Kim

State University of New York at Buffalo, USA

University of New Mexico, Albuquerque, USA University of Nevada, Reno, USA

Mehran Mojarrad

Eli Lilly & Company, Indiana, USA

Written by leading authorities, this unique work examines the aqueous chemistry of vanadium (V). Focusing on its oxidation state, the book highlights the use of 51V NMR spectroscopy. It covers reactions of vanadium with biologically important ligands such as amino acids, peptides, and sulfhydryl ligands. It reviews vanadium’s role in biological systems and pharmacological effects and addresses the importance of ligand electronic properties in determining speciation, coordination geometry, and heteroligand reactivity. It also describes recent advances in practical applications such as in the non-aqueous vanadium oxide bronze battery systems, which are particularly suited to medical applications.

Using an interdisciplinary approach to smart materials and structures, this book explores the powerful new technology of electroactive polymeric nanosensors, nanoactuators, and artificial muscles. It highlights the experimental results of their properties and characteristics and describes several apparatuses for modeling and testing various artificial muscles. It also presents the theories, modeling, and numerical simulations of ionic polymeric artificial muscles’ electrodynamics and chemodynamics, and features current industrial and medical applications of IPMNCs. The book contains a CD-ROM with color images, muscle systems in action, and a presentation on state-of-the-art research.

Catalog no. 46136, ISBN: 978-1-4200-4613-7 2007, 6-1/8 x 9-1/4, 250 pp. Suggested Price: $154.95 / £86.00

Catalog no. C7133, ISBN: 978-1-58488-713-3 2007, 6-1/8 x 9-1/4, 480 pp. Suggested Price: $104.95 / £57.99

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Bioceramics and Their Clinical Applications Edited by

Fundamentals of Biocompatibility, Fourth Edition Jonathan Black

Tadashi Kokubo

Clemson University (Professor Emeritus), South Carolina, USA

Chubu University, Japan

With contributions from leading international academics, this book reviews the range of bioceramics, their properties, and spectrum of clinical uses. It begins with a discussion of structure, mechanics, and biological interactions, then reviews fabrication, microstructure, and properties of specific bioceramics and glasses, concentrating on the most promising materials. The final group of chapters covers the clinical application of bioceramics in joint replacement, bone grafts, tissue engineering and dentistry. Bioceramics and Their Clinical Applications is a useful resource for biomaterials scientists and engineers, as well as for clinicians and the academic community. Catalog no. WP7207, ISBN: 978-1-4200-7207-5 2008, 6-1/8 x 9-1/4, 600 pp. Suggested Price: $339.95 / £179.00

Bio-Implant Interface

Biological Performance of Materials: Fundamentals of Biocompatibility, Fourth Edition focuses on principles of biological performance at a fundamental level, analyzing interactions between organisms and nonliving materials used in medical devices. The book is divided into three sections: the material response to biological systems, host response to biomaterials, and test methods for determining biological response in vitro as well as in animal models and clinical settings. Subsections summarize the physical properties of commonly used metallic, polymeric, and ceramic biomaterials and provide a guide to understanding the clinical performance of implanted biomaterials. Catalog no. 3959, ISBN: 978-0-8493-3959-2 2006, 6-1/8 x 9-1/4, 520 pp. Suggested Price: $109.95 / £60.99

Improving Biomaterials and Tissue Reactions

Biologically Inspired Textiles

Jan Erik Ellingsen and S. Petter Lyngstadaas

Edited by

A. Abbott and M. Ellison

University of Oslo, Norway

Clemson University, South Carolina, USA

Bringing together a remarkable group of scientists, Bio-Implant Interface: Improving Biomaterials and Tissue Reactions describes interactions at the interface between biomaterials and living tissue. Much of the focus is on the importance of the implant surface’s topography and chemistry to its interaction with the biological environment. The book also pays particular attention to biomineralization, along with the biological content of the interface and its role in directing cellular response along desired pathways. It includes a section that explores the potential of advances on the horizons of current research and more than 175 illustrations, many in color.

Written by a distinguished team of international authors, Biologically Inspired Textiles explores the current state of the art in this research arena and examines how biomimetics are increasingly applied to new textile technologies. It discusses the principles, production and properties of biomimetics. Chapters include recombinant DNA technologies and their application for protein production, spinning of fibres from protein solutions, and structure and function in relationships in spider silk. Building on this foundation, the book then provides a review of the application of biomimetics to a range of textile applications, including the design of clothing and self cleaning textiles.

Catalog no. 1474, ISBN: 978-0-8493-1474-2 2003, 6-1/8 x 9-1/4, 464 pp. Suggested Price: $185.95 / £103.00

Catalog no. WP7985, ISBN: 978-1-4200-7985-2 January 2009, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $219.95 / £115.00

Biomaterials & Medical Devices

Biological Performance of Materials

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Biomaterials Biomaterials

Edited by

Biomaterials & Medical Devices

Joyce Y. Wong

Joon B. Park

Joseph D. Bronzino

For medical devices that must be placed inside the body, the right choice of material is the most important aspect of design. To make sure such devices are safe, reliable, economical, and biologically and physiologically compatible, the modern biomedical engineer must have a broad knowledge of currently available materials and the properties that affect their in-service performance. With one-third new material along with chapters drawn from the third edition of the best-selling Biomedical Engineering Handbook, Biomaterials surveys the wide variety of biomaterials in present use as well as materials resulting from novel micro- and nanoscale technologies.

With contributions from international experts, Biomaterials: Principles and Applications offers an accessible, comprehensive review of all the major biomaterials in this rapidly growing field. The book provides readers with an understanding of the uses of biomaterials in medicine and dentistry and the rational basis for these applications. It covers biodegradable polymeric materials and their relation to tissue engineering, biologic materials, and biomaterial applications in soft and hard tissues. Concise, topical, yet not overly technical, with nearly 100 figures and tables, no other book covers the entire field of biomaterials so succinctly.

Catalog no. 7888, ISBN: 978-0-8493-7888-1 2007, 7 x 10, 296 pp. Suggested Price: $93.95 / £51.99

Catalog no. 1491, ISBN: 978-0-8493-1491-9 2003, 7 x 10, 250 pp. Suggested Price: $134.95 / £74.99

Boston University, Massachusetts, USA Trinity College, Hartford, Connecticut, USA

Textbook

Principles and Applications

Biomaterials

A Nano Approach Seeram Ramakrishna, Murugan Ramalingam, T.S. Sampath Kumar, and Winston O. Soboyejo Using a multi-disciplinary approach, this book examines basic concepts, various processing methodologies, and techniques involved in the preparation and characterization of nanobiomaterials that are specific to biomedical applications. Biomaterials: A Nano Approach spans the historical development of biomaterials to current advances in the field. It describes how basic concepts in nanotechnology are applied to the processing of novel nanobiomaterials, including nanostructured metals and alloys. Presenting illustrative examples and a variety of applications, this text offers a solid framework for understanding present and future trends of biomaterials in human health care systems. Catalog no. 47817, ISBN: 978-1-4200-4781-3 March 2009, 6-1/8 x 9-1/4, 265 pp. Suggested Price: $99.95 / £44.99

University of Iowa, Iowa City, USA Trinity College, Hartford, Connecticut, USA

Biomaterials Fabrication and Processing Handbook Edited by

Paul K. Chu

City University of Hongkong, China

Xuanyong Liu

Shanghai Institute of Ceramics, China

This volume focuses on a variety of production and processing aspects of the latest biomaterials. It discusses how scaffolds are used in tissue engineering and describes common implant materials, such as hard tissue, blood contacting, and soft tissue. The book also examines the important role nanotechnology plays in the preparation of drugs, protein delivery, tissue engineering, cardiovascular biomaterials, hard tissue replacements, biosensors, and bio-MEMS. With contributions from renowned international experts and extensive reference lists in each chapter, this book provides detailed, practical information to produce biomaterials and employ them in biomedicine. Catalog no. 7973, ISBN: 978-0-8493-7973-4 2008, 7 x 10, 720 pp. Suggested Price: $149.95 / £83.00

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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Bio-MEMS

D. Orgill

Brigham and Women’s Hospital, Boston, Massachusetts, USA

Technologies and Applications

C. Blanco

Edited by

University Hospital Maastricht, The Netherlands

Wanjun Wang and Steven A. Soper

Louisiana State University, Baton Rouge, USA

A comprehensive review of the range of biomaterials for treating skin loss, this book begins with a discussion of the basics of skin replacement with chapters on such topics as markets and regulation, biomechanics, and the biological environment of skin. It then reviews epidermal and dermal replacement technology with chapters on alternative delivery of keratinocytes, collagen-based and human origin-based dermal replacement, and lyophilized xenogenic products. The book closes with an exploration of combined dermis and epidermal replacement technologies and provides a summary of skin replacement principles. Catalog no. N10002, ISBN: 978-1-4200-9989-8 February 2009, 6 x 9, 320 pp. Suggested Price: $239.95 / £125.00

Biomedical Polymers Edited by

This book considers both the unique characteristics of biological samples and the challenges of microscale engineering. Divided into three main sections, it first examines fabrication technologies using non-silicon processes, which are suitable for the materials more commonly used in medical/biological analyses. These include UV lithography, LIGA, nanoimprinting, and hot embossing. Attention then shifts to microfluidic components and sensing technologies for sample preparation, delivery, and analysis in microchannels and microchambers. The final section outlines various applications and systems at the leading edge of bio-MEMS technology in a variety of areas such as drug delivery and proteomics. Catalog no. DK532X, ISBN: 978-0-8493-3532-7 2007, 6-1/8 x 9-1/4, 488 pp. Suggested Price: $144.95 / £79.99

Bone Repair Biomaterials

Biomaterials & Medical Devices

Biomaterials for Treating Skin Loss

Edited by

Mike Jenkins

University of Birmingham, UK

J.A. Planell, S.M. Best, D. Lacroix, and A. Merolli

A review of the latest research on biomedical polymers, this book discusses natural, synthetic, biodegradable and non bio-degradable polymers and their applications. Chapters discuss polymeric scaffolds for tissue engineering and drug delivery systems, the use of polymers in cell encapsulation, their role as replacement materials for heart valves and arteries, and their applications in joint replacement. The book also discusses the use of polymers in biosensor applications. Containing contributions from pioneers throughout the field, this volume is an essential reference for scientists and all those developing and using this important group of biomaterials.

A fundamental aspect of the rapidly expanding medical care sector, bone repair continues to benefit from emerging technological developments. This text provides researchers and students with a comprehensive review of the materials science and engineering principles behind these developments. The first part reviews the fundamentals of bone repair and regeneration. Further chapters discuss the science and properties of biomaterials used in bone repair, including both metals and biocomposites. Finaly, the book analyzes device considerations such as implant lifetime and failure, and discusses potential applications and the ethical issues that continually confront researchers and clinicians.

Catalog no. WP4451, ISBN: 978-1-4200-4451-5 2008, 6 x 9, 224 pp. Suggested Price: $299.95 / £167.00

Catalog no. N10044, ISBN: 978-1-4398-0195-6 May 2009, 6 x 9, 320 pp. Suggested Price: $239.95 / £126.00

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Biomaterials & Medical Devices

Cellular Response to Biomaterials

Imaging, Testing and Modelling

Edited by

L. Di Silvio

Richard Curtis and Timothy Watson

Written by international experts under the guidance of a pioneering editor, this volume discusses the response of cells to a wide range of biomaterials targeted at specific medical applications. It first examines cell responses to a variety of polymers and ceramics, with discussions on degradable polymers and biocompatibility. The next section examines cell responses and regenerative medicine, with topics such as vascular grafts, nerve repair and Bioglass®. Lastly, the text explores the effect of surfaces and proteins on cell response. Specific chapters review nano-engineered surfaces, the influence of plasma proteins on bone cell adhesion, and surface modification of titanium implants.

A review of the biomaterials used in dentistry, this book explores their performance and how it can be measured and optimized. The text covers optical and electron microscopy imaging techniques for dental biomaterial interfaces, along with specific materials such as dental cements, fibre-reinforced composites, metals and alloys. It provides an analysis of stresses, fracture, wear, and aging in dental biomaterials and evaluates the performance of dental adhesives and resin-dentin bonds. It also discusses ways of assessing the effectiveness of dental handpieces, crowns, implants, and prostheses, and examines the use of computer models.

Kings College London, UK

Catalog no. WP9373, ISBN: 978-1-4200-9373-5 February 2009, 6-1/8 x 9-1/4, 500 pp. Suggested Price: $289.95 / £153.00

Dental Biomaterials

Degradation Rate of Bioresorbable Materials

Prediction and Evaluation Edited by

King’s College, London, UK

Catalog no. WP7209, ISBN: 978-1-4200-7209-9 2008, 6-1/8 x 9-1/4 Suggested Price: $289.95 / £153.00

Design Controls for the Medical Device Industry Marie B. Teixeira

QA/RA Compliance Connection, Inc., Odessa, Florida, USA

Richard Bradley

F. J. Buchanan

Global Consulting Network, Inc., Palm Harbor, Florida, USA

Bioresorbable materials can be employed to provide significant advances in drug delivery systems and medical implants. The rate of material degradation is critical to performance of both implants and the controlled release of drugs; Degradation Rate of Bioresorbable Materials: Prediction and Evaluation addresses the practicalities of this subject in detail. The first section provides an overview of bioresorbable materials and the biological environment. Degradation mechanisms are reviewed in the second group of chapters in the book, followed by bioresorption test methods in the third part. The fourth section discusses factors influencing bioresorption, and finally, clinical applications are reviewed.

Design Controls for the Medical Device Industry provides realworld examples, strategies, and templates for the implementation of effective design control programs that meet ISO 9000 and FDA QSR standards and regulations. It also offers product development models for the production of safe, durable, and cost-efficient medical devices and systems. The book details procedures utilized by leading companies to successfully meet FDA and end-user requirements, manufacture high-quality products, and improve and generate profit. It presents blueprints for the application, evaluation, and refinement of quality assurance and performance practices, from product launch through engineering and assembly.

Catalog no. WP7971, ISBN: 978-1-4200-7971-5 January 2009, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $259.95 / £135.00

Catalog no. DK5666, ISBN: 978-0-8247-0830-6 2003, 6 x 9, 254 pp. Suggested Price: $175.95 / £98.00

Queen’s University Belfast, UK

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Textbook

Design of Biomedical Devices and Systems Second Edition Paul H. King

Vanderbilt University, Nashville, Tennesee, USA

Richard C. Fries

An Introduction to Biomaterials Edited by

Scott A. Guelcher and Jeffrey O. Hollinger

Carnegie Mellon University, Pittsburgh, Pennsylvania, USA

Baxter Healthcare, Round Lake, Illinois, USA

Series: Biomedical Engineering, 11

The design and functional complexity of medical devices have increased over the past 50 years, evolving from cardiac pacemakers to magnetic resonance imaging. Design of Biomedical Devices and Systems provides a comprehensive overview of this area — including topics related to databases, process analysis, and device improvement — from a strong design perspective. Aimed at senior undergraduates, this text covers all aspects of design that must be considered for complex biomedical projects. This new second edition features additional information on device definition and reliability, as well as testing and hardware verification. All chapters are updated to reflect the latest advances in the field.

An Introduction to Biomaterials emphasizes applications of biomaterials for patient care. Written by leading authorities on key biomaterial types, this book underscores the process of biomaterial design, development directed toward clinical application, and testing that leads to therapies for clinical targets. It provides a lucid perspective on the standards available and the logic behind the standards in which biomaterials address clinical needs. This volume offers well-rounded chapters on consensus standards and regulatory approaches to testing paradigms, specific classes of biomaterials, and clinical topics that integrate materials sciences and patient applications.

Catalog no. 61798, ISBN: 978-1-4200-6179-6 January 2009, 7 x 10, 424 pp. Suggested Price: $119.95 / £66.99

Catalog no. 2282, ISBN: 978-0-8493-2282-2 2006, 7 x 10, 576 pp. Suggested Price: $104.95 / £57.99

Designing Usability into Medical Products Michael E. Wiklund

Wiklund Research & Design, Inc., Concord, Massachusetts, USA

Joint Replacement Technology

Biomaterials & Medical Devices

Textbook

Edited by

Stephen B. Wilcox

P.A. Revell

Design Science, Philadelphia, Pennsylvania, USA

Eastman Dental Institute, London, UK

Advocating a user-centered approach to medical technology design, this book covers the essential processes and specific techniques necessary to produce safe, effective, usable, and appealing medical systems and products. Written by experts on user-centered research, design, and evaluation, the book provides a range of alternative approaches. The authors explore how to make medical devices safe and effective by involving users in the design process. They discuss specific design and evaluation methods and tools, present case studies of user-friendly medical technologies and corporate human factors programs, and supply related resources for medical design professionals.

Increasing numbers of joint revision and replacement operations drive the demand for improved prostheses. This book reviews developments in joint replacement technology, covering the most pertinent materials science and engineering issues as well as specific joints, clinical trial results and sterilization techniques. It discusses biomechanics, tribology, and the chemical environment of the body, and surveys the engineering of joint replacement. The second part of the book reviews specific materials, bearing surfaces and bone cements, in addition to the failure mechanisms and lifetime prediction of joints. It also discusses the biological environment and the interaction of replacement joints.

Catalog no. 2843, ISBN: 978-0-8493-2843-5 2005, 6-1/8 x 9-1/4, 376 pp. Suggested Price: $124.95 / £69.99

Catalog no. WP7962, ISBN: 978-1-4200-7962-3 January 2009, 6-1/8 x 9-1/4, 600 pp. Suggested Price: $299.95 / £163.00

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Medical Devices and Systems

Textbook

Biomaterials & Medical Devices 62

A Laboratory Course in Biomaterials

Edited by

Wujing Xian

Series: The Biomedical Engineering Handbook, Third Edition

This book presents a complete laboratory course suitable for undergraduate curriculum in biomaterials and bioengineering at the senior or junior level. A laboratory manual, it provides step-by-step instructions that can easily be adapted in many different laboratory settings. This is a practical guide for instructors to train students in laboratory skills, data analysis, problem solving, and scientific writing, giving them insight to the connection between scientific principles and laboratory practices. Most of the experiments are adapted from recent research papers and reflect the forefront of progress in various disciplines of bioengineering and biomaterials science.

Already referred to as a “bible” of biomedical engineering, the third edition of The Biomedical Engineering Handbook includes so much revised and updated material that it has expanded from two volumes into a three-volume set. From theory to state-of-the-art applications, the second volume of the set, Medical Devices and Systems, has been updated to reflect the most recent advances in both research and practice in all pertinent fields. The book contains new sections on medical informatics and bioinformatics and authoritatively covers medical instruments and devices, clinical engineering, medical sensor and imaging technologies, and biomedical signal analysis.

Catalog no. 75829, ISBN: 978-1-4200-7582-3 May 2009, 7 x 10, 216 pp., Soft Cover Suggested Price: $59.95 / £36.99

Catalog no. 2122, ISBN: 978-0-8493-2122-1 2006, 7 x 10, 1376 pp. Suggested Price: $134.95 / £74.99

University of Illinois at Urbana-Champaign, USA

The Medical Device R&D Handbook Theodore R. Kucklick

TRKD Medical Devices, Los Gatos, California, USA

The Medical Device R&D Handbook is a practical, hands-on digest of medical device engineering that presents information that is often hard to find or gained by on-the-job experience. Highlights include using rapid-prototyping methods to develop medical devices and how to choose the best methods for certain applications, such as form, fit and function, and meeting device regulatory requirements. It offers special techniques for iterating devices with the best possible results at the lowest cost. This book, which also includes interviews showcasing innovative principles in application by pioneers in the medical device field, will shorten the time it takes for engineers to become productive medical device designers. Catalog no. 2717, ISBN: 978-0-8493-2717-9 2006, 6-1/8 x 9-1/4, 376 pp. Suggested Price: $144.95 / £79.99

Joseph D. Bronzino

Trinity College, Hartford, Connecticut, USA

For information on the complete Handbook, see page 68.

Natural Fibers, Biopolymers, and Biocomposites Edited by

Amar K. Mohanty, Manjusri Misra, and Lawrence T. Drzal Michigan State University, East Lansing, USA

This book discusses the combination of fibers with polymer matrices from both non-renewable and renewable resources. The first source to focus on biobased materials, it explains the rise of petrochemical and plastic products, the problems associated in their disposal, and how biopolymers offer a realistic solution to these problems. The text discusses recent trends and opportunities for the future use of biocomposites as alternatives to petroleum-based composites, integrating the principles of sustainability, industrial ecology, ecoefficiency, and green chemistry and engineering into developing next-generation materials, products, and processes. Catalog no. 1741, ISBN: 978-0-8493-1741-5 2005, 6-1/8 x 9-1/4, 896 pp. Suggested Price: $175.95 / £98.00

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Natural-Based Polymers for Biomedical Applications Edited by

R.L. Reis, N.M. Neves, Joao F. Mano, Manuela E. Gomes, Alexandra P. Marques and Helena S. Azevedo

Second Edition, Revised and Expanded Edited by

Severian Dumitriu

University of Sherbrooke, Canada

Natural origin biopolymers are attractive for use in biomedical applications, partly due to their biocompatibility and degradation characteristics. This book comprehensively reviews this important subject in six in-depth sections. Part 1 discusses the sources, properties, modification, and processing of natural-based polymers. Surface aspects are reviewed in the second section, and parts 3 and 4 cover natural-origin materials for tissue engineering and regenerative medicine, discussing scaffolds, hydrogels and injectable systems. The sustained release of molecules is reviewed in the fifth part of the book, followed by the biocompatibility of natural-based polymers in the final section.

Offering nearly 7000 references-3900 more than the first editionPolymeric Biomaterials, Second Edition is an up-to-the-minute source for plastics and biomedical engineers, polymer scientists, biochemists, molecular biologists, macromolecular chemists, pharmacists, cardiovascular and plastic surgeons, and graduate and medical students in these disciplines. Completely revised from the previous edition, it includes coverage of genetic engineering, synthesis of biodegradable polymers, hydrogels, and mucoadhesive polymers, as well as polymers for dermacosmetic treatments, burn and wound dressings, orthopedic surgery, artificial joints, vascular prostheses, and in blood contacting systems.

Catalog no. WP7607, ISBN: 978-1-4200-7607-3 January 2009, 6 x 9, 760 pp. Suggested Price: $319.95 / £175.00

Catalog no. DK1811, ISBN: 978-0-8247-0569-5 2002, 1168 pp. Suggested Price: $299.95 / £170.00

Biomaterials & Medical Devices

Polymeric Biomaterials

Polymers for Dental and Orthopedic Applications Orthopaedic Bone Cements

Edited by

Ulrich Salz

Shalaby W. Shalaby

Poly-Med Inc., Anderson, South Carolina, USA Ivoclar-Vivident, A.G., Schaan, Liechtenstein

S. Deb

King’s College London, UK

Series: Advances in Polymeric Biomaterials

With an increasing number of bone cements available, it is vital that the correct material is selected for specific clinical procedures. A review of the most recent research in this field, this book covers such topics as hip replacements, verteboplasty and wear particles and osteolysis. It reviews materials and types of cement such as acrylic, polymethylmethacrylate and calcium phosphate cements, and addresses the mechanical properties of bone cements such as fracture toughness and dynamic creep. The book closes with an examination of methods to enhance the properties of bone cements such as antibiotic loaded bone cements and bioactive cements.

Surveying major progress in polymer science and technology for dental, maxillofacial, and orthopedic applications, this book provides a unique illustration of the conceptual development of novel biomaterials and processes designed to meet targeted clinical needs. Preeminent experts with extensive experience in product development, bioengineering, education, and clinical applications cover topics ranging from polymeric materials for dental and maxillofacial application to joint repair and replacement, polymeric composites, and tissue engineering. The book also examines topics that are common to both dental and orthopedic fields, such as osseointegration and infection management.

Catalog no. WP9302, ISBN: 978-1-4200-9302-5 January 2009, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $279.95 / £156.00

Catalog no. 1530, ISBN: 978-0-8493-1530-5 2007, 6-1/8 x 9-1/4, 440 pp. Suggested Price: $175.95 / £98.00

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Biomaterials & Medical Devices / Biomechanics 64

Reliable Design of Medical Devices Second Edition

Smart Textiles for Medicine and Healthcare Materials, Systems and Applications Edited by

Richard Fries

L. Van Langenhove

As medical devices increase in complexity, concerns about efficacy, safety, quality, and longevity increase in stride. The second edition of Reliable Design of Medical Devices presents the basic concepts and the major issues involved in the design of medical devices, updating the information to stay at the forefront of developments in the industry. This edition includes topics such as Six Sigma philosophy, electronic signature, material selection and biocompatibility, and quick response manufacturing. The book helps manufacturers implement a reliability assurance program while conforming to current regulations and will also help purchasers formulate effective vendor evaluation methods.

With its distinguished editor and team of international contributors, Smart Textiles for Medicine and Healthcare provides unique insight into recent developments in how smart textiles are being used in the medical field. The book covers topics such as wound care materials, drug-based release systems, and electronic sensors for health care. It discusses the role of smart textiles in monitoring the health of particular groups such as pregnant women, children, the elderly, and those with particular physical disabilities. This volume is an essential resource for researchers working on intelligent textiles in the medical and healthcare fields.

Baxter Healthcare, Round Lake, Illinois, USA

Catalog no. DK3104, ISBN: 978-0-8247-2375-0 2006, 6-1/8 x 9-1/4, 504 pp. Suggested Price: $164.95 / £92.00

Shape Memory Alloys for Biomedical Applications

University of Ghent, Belgium

Catalog no. WP4448, ISBN: 978-1-4200-4448-5 2007, 6 x 9, 312 pp. Suggested Price: $249.95 / £139.00

Textbook

Nihon University, Chiyoda-ku, Tokyo

Applied Biomedical Engineering Mechanics

S. Mayazaki

Dhanjoo N. Ghista

Shape memory metals are suitable for a wide range of biomedical devices including applications in dentistry, bone repair, urology and cardiology. This book provides a thorough review of shape memory metals and devices for medical applications. The first part of the book discusses the materials, primarily Ti-Ni based alloys; the text covers mechanical properties, thermodynamics, and composition as well as fabrication of parts, chemical reactivity, surface modification, and biocompatibility. It book also examines stents, orthodontic devices and endodontic instruments. Finally, future developments in this area are discussed including alternatives to Ti-Ni based shape memory alloys.

Presenting the latest innovations, this text highlights advances in tissue, musculoskeletal, locomotive, orthopedic, occupational, ergonomic, sports, cardiovascular, cardiac, and pulmonary biomechanics. Based on years of teaching experience, the author uses illustrative examples and detailed explanations to show how mechanics disciplines can be applied to a wide range of clinical applications, including the analysis of physiological and organsystem processes; the creation of physiologically compatible organassist systems and devices; the performance of pre-surgical analysis in order to develop optimal surgical approaches; and the design of vehicle-occupant systems for occupant comfort.

Catalog no. WP7966, ISBN: 978-1-4200-7966-1 January 2009, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $239.95 / £126.00

Catalog no. DK8315, ISBN: 978-0-8247-5831-8 January 2009, 6-1/8 x 9-1/4, 552 pp. Suggested Price: $139.95 / £77.99

Edited by

T. Yoneyama

University of Tsukuba, Japan

Parkway College, Singapore

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Textbook

Biofluid Mechanics

Textbook

Krishnan B. Chandran

Biomechanics and Exercise Physiology

University of Iowa, Iowa City, USA

Ajit P. Yoganathan

Georgia Institute of Technology, Atlanta, USA

Stanley E. Rittgers

Quantitative Modeling Arthur T. Johnson

University of Akron, Ohio, USA

University of Maryland, College Park, Maryland, USA

Based on the authors’ courses on cardiovascular fluid mechanics, this textbook is ideal for an introductory course on fluid mechanics in the human circulation. It covers fluid and solid mechanics as well as cardiovascular physiology; vascular implants and measurement techniques in the cardiovascular system; design and fluid mechanical evaluation of artificial heart valves; and fluid mechanical alterations related to vascular graft and stent implants. The book includes models illustrating fluid mechanics in the human circulation at the arterial level and detailed derivations of classic solutions and real-life applications.

Using numerous worked examples to demonstrate what and when to calculate, this text covers more than just the fundamentals of exercise physiology; it demonstrates the vast amount of physiological material that can be quantitatively predicted and describes how to translate this information into applications. The book examines the energetics of exercise, biomechanics, circulation, respiration, and thermoregulation, and includes numerical examples and homework problems. With an emphasis on quantitative description, it contains tables and illustrations which make this book helpful for estimating magnitudes, determining trends, and illustrating concepts.

Catalog no. 7328, ISBN: 978-0-8493-7328-2 2007, 6 x 9, 432 pp. Suggested Price: $104.95 / £57.99

Catalog no. DK5813, ISBN: 978-1-57444-906-8 2007, 7 x 10, 688 pp. Suggested Price: $124.95 / £69.99

Biomechanical Engineering of Textiles and Clothing Edited by

Biomechanics

The Human Circulation

Biomechanics

Principles and Applications

Edited by

Donald R. Peterson

Y. Li X-Q. Dai

University of Connecticut, Farmington, USA

Joseph D. Bronzino

Hong Kong Polytechnic University, Hong Kong

Trinity College, Hartford, Connecticut, USA

Biomechanical Engineering of Textiles and Clothing addresses issues of designing and producing textiles and clothing for optimum interaction and contact with the body. It covers the fundamental theories, principles and models behind design and engineering for the human body’s biomechanics, contact problems arising between textiles/clothing and the body, and the mechanics of fibers, yarns, textiles, and clothing. Material properties are discussed in relation to mechanical performance. The book concludes with practical examples of clothing applications to illustrate how to carry out biomechanical engineering design for specific applications.

Drawn from the third edition of the widely acclaimed Biomedical Engineering Handbook, Biomechanics is a comprehensive presentation of the current principles and applications of biomechanics, integrating both systems and subsystems models. Presenting substantial updates and revisions and a new chapter on current methods and strategies for modeling cellular mechanics, the book covers musculoskeletal mechanics, biofluid mechanics and circulatory dynamics, the functioning of the ear, and the performance characteristics of the human body during exercise and exertion. It includes more than 140 illustrations, 60 tables, and a variety of useful equations to assist in modeling biomechanical behaviors.

Catalog no. WP9094, ISBN: 978-0-8493-9094-4 2007, 6 x 9, 412 pp. Suggested Price: $279.95 / £156.00

For information on the complete Handbook, see page 68.

Catalog no. 8534, ISBN: 978-0-8493-8534-6 2008, 7 x 10, 352 pp. Suggested Price: $93.95 / £51.99

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For more information and a complete list

Biomechanics in Ergonomics Second Edition Edited by

Ergonomics for Rehabilitation Professionals Edited by

Shrawan Kumar

University of North Texas, Fort Worth, USA

Two of the most important goals of ergonomics are the comfort, and the health and safety of the working population. Written by leaders in the field, this second edition of Biomechanics in Ergonomics presents thoroughly updated and new material regarding the biomechanics of tissues and organs in the workplace. This text establishes a foundation for the understanding of gross biomechanical loads on the human system at the tissue level. It describes biomechanical risk factors and supplies exposure assessment tools and techniques. Comprehensive in scope, the book is suitable for use by ergonomic engineers and physical therapists, and as a textbook for ergonomics courses.

Designed to meet the diverse needs of therapists, this book presents a new approach to rehabilitation that integrates ergonomics concepts to address the wide range of problems commonly encountered by professionals. The first section addresses general concepts such as anthropometry and tissue mechanics. The next part explores whole body biomechanics, demonstrating the ergonomic effects of physiological and biomechanical factors. The third section focuses on regional biomechanics, explaining the rationale for ergonomic intervention. Finally, the book offers a detailed discussion of the ergonomic paradigm in rehabilitation, including the use of physical demands analysis.

Catalog no. 7908, ISBN: 978-0-8493-7908-6 2008, 7 x 10, 744 pp. Suggested Price: $99.95 / £55.99

Catalog no. 8146, ISBN: 978-0-8493-8146-1 April 2009, 6-1/8 x 9-1/4, 728 pp. Suggested Price: $99.95 / £60.99

University of North Texas, Fort Worth, USA

Biomechanics

Foot and Ankle Motion Analysis Textbook

Biomechanics of the Upper Limbs

Mechanics, Modelling and Musculoskeletal Injuries Andris Freivalds

Clinical Treatment and Technology Edited by

Gerald F. Harris

Marquette University, Milwaukee, Wisconsin, USA

Peter A. Smith

Shriners Hospital for Children, Chicago, Illinois, USA

Richard M. Marks

Penn State University, University Park, USA

Medical College of Wisconsin, Milwaukee, USA Series: Biomedical Engineering, 12

Combining basic biomechanics with practical bioengineering issues, this book provides more than the general introductions to cumulative trauma disorders and medical management-related books currently on the market. The author covers the musculoskeletal components, their models, and the measurement and prediction of injury potential. The author sets the stage with a basic introduction to biomechanical principles and goes on to cover gross structure of the musculoskeletal system, organization of muscles and muscle anatomy, modeling of muscle mechanics, models of the upper limbs, types of musculoskeletal disorders, and the scientific evidence of risk factors.

Originating as a one-day workshop sponsored by the Shriner’s Hospitals and the National Institutes of Health, Foot and Ankle Motion Analysis: Clinical Treatment and Technology provides a single source reference for the latest assessment technologies and their clinical applications. Presenting basic and advanced clinical applications in pediatric and adult cases, the book also introduces the technological advances themselves from a quantitative perspective. It describes novel approaches and emerging horizons related to mechanical paradigms, imaging, kinetics, robotics and simulation, tri-planar force sensing, and more. The book also includes a chapter of references and sources of support for future research and development prospects.

Catalog no. TF2279, ISBN: 978-0-7484-0926-6 2004, 6-1/8 x 9-1/4, 624 pp. Suggested Price: $114.95 / £63.99

Catalog no. 3971, ISBN: 978-0-8493-3971-4 2008, 6-1/8 x 9-1/4, 704 pp. Suggested Price: $185.95 / £103.00

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

Biological and Bioenvironmental Heat and Mass Transfer

Principles of Biomechanics Ronald Huston

University of Cincinnati, Ohio, USA Series: Dekker Mechanical Engineering

Ashim K. Datta

Cornell University, Ithaca, New York, USA

Presenting the fundamental concepts that are required for further study and research in this field, Principles of Biomechanics focuses on biosystems and the human body in particular. After a brief introduction to the concepts of biosystem modeling, the book discusses elementary mechanics, including methods of analysis, and introduces the human skeletal anatomy. Subsequent chapters address the mechanics of deformable bodies, dynamics, tissue biomechanics, ergonomics, kinematics, fluid mechanics, and circulatory systems. With a wide range of examples and problems, this complete text also provides numerical procedures and specific applications in performance, injury, and rehabilitation.

Providing a solid foundation in heat and mass transport, this book covers engineering principles of heat and mass transfer. The author discusses biological content, context, and parameter regimes and supplies practical applications for biological and biomedical engineering, industrial food processing, environmental control, and waste management. The book contains end-of-chapter problems, sections highlighting key concepts and important terminology, cross-references for easy access to key concepts and formulas, detailed examples of transport phenomena, and descriptions of physical processes. It covers mechanisms of diffusion, capillarity, convection, and dispersion.

Catalog no. DK494X, ISBN: 978-0-8493-3494-8 January 2009, 6-1/8 x 9-1/4, 442 pp. Suggested Price: $99.95 / £60.99

Catalog no. DK1966, ISBN: 978-0-8247-0775-0 2002, 8-1/2 x 11, 424 pp. Suggested Price: $93.95 / £51.99

Biomechanics / Biomedical Engineering

Textbook

Biofluid Dynamics

Principles and Selected Applications

Textbook

Clement Kleinstreuer

Arthur T. Johnson

North Carolina State University

University of Maryland, College Park, USA

Biofluid Dynamics builds a solid understanding of medical implants and devices from a bioengineering standpoint. The text features extensive worked examples and mathematical appendices; exercises and project assignments to stimulate critical thinking and build problem solving skills; numerous illustrations, including a 16-page full-color insert; computer simulations of biofluid dynamics processes and medical device operations; tools for solving basic biofluid problems; and a glossary of terms. The text can be used as a primary selection for a comprehensive course or for a twocourse sequence, and it is also a suitable reference for professionals in biomedical engineering and medicine.

Intended as an introductory text on biology from an engineering perspective, this resource elaborates on concepts and technology with an emphasis on the utilization of living things. Rather than treating biology as a science requiring memorization of connections and classifications, the book explores its relevance as an application area for engineering analysis and design. The author takes a broad approach, encompassing everything from genetics and cellular structure to grand ecological systems. Because it is an introductory text, ideas and concepts are primary. Except for a unique chapter on scaling, there are few equations and little quantitative analysis.

Catalog no. 2221, ISBN: 978-0-8493-2221-1 2006, 6-1/8 x 9-1/4, 528 pp. Suggested Price: $104.95 / £57.99

Biology for Engineers

Catalog no. 77635, ISBN: 978-1-4200-7763-6 July 2009, 8-1/2 x 11, 850 pp. Suggested Price: $99.95 / £44.99

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For more information and a complete list Textbook

Biomedical Engineering Fundamentals

Biomedical Engineering Principles Arthur B. Ritter

Edited by

Stevens Institute of Technology, Hoboken, New Jersey, USA

Joseph D. Bronzino

Stanley Reisman

Series: The Biomedical Engineering Handbook, Third Edition

Bozena B. Michniak

The first of three volumes in The Biomedical Engineering Handbook, Biomedical Engineering Fundamentals builds a strong foundation in the underlying concepts of biomedical engineering. Beginning with an overview of physiology and physiological modeling, simulation, and control, this volume explores bioelectric phenomena, biomaterials, and biomechanics. It also discusses human factors with sections on rehabilitation and human performance engineering. The final section delves into ethical issues. Preeminent experts from around the world share their expertise with many new and updated chapters representing state-of-the-art technologies and practices, including a section on neuroengineering.

Integrating engineering, medicine, biology, and physics, this book clearly defines basic principles in image processing and biomechanics, modeling physiological processes, and bioelectric signal analysis to build a solid understanding of devices and designs for improved functioning of the human body. It includes cutting-edge discussions of tissue engineering, cardiovascular components, bone regrowth, and nerve regeneration. Other topics include technologies at the forefront of cardiac care, such as total artificial hearts, left ventricular assist devices, and stents, along with issues related to minimally invasive and robotic surgery, next-generation imaging devices, and nanodevices.

For information on the complete Handbook, see the following entry.

Catalog no. DK1283, ISBN: 978-0-8247-9616-7 2005, 6 x 9, 680 pp. Suggested Price: $104.95 / £57.99

Trinity College, Hartford, Connecticut, USA

Biomedical Engineering

Catalog no. 2121, ISBN: 978-0-8493-2121-4 2006, 7 x 10, 1560 pp. Suggested Price: $154.95 / £86.00

New Jersey Institute of Technology, Newark, USA Rutgers University, Pisacataway, New Jersey, USA

The Biomedical Engineering Handbook 68

Third Edition – Three-Volume Set Edited by

Joseph D. Bronzino

Trinity College, Hartford, Connecticut, USA

Already referred to as the “bible” of biomedical engineering, the third edition of The Biomedical Engineering Handbook is even more vast in its scope and depth than the previous two editions. Covering the breadth of the field, this edition includes so much updated material that it has expanded into a three-volume set. Individually, each volume provides a convenient, sharply focused guide to specialized information. Together, these three volumes form the most comprehensive, authoritative, and interdisciplinary reference available, conveniently organized for quick access. This edition includes new sections on neuroengineering, infrared imaging, bioinformatics, molecular biology, and bionanotechnology. For information on individual volumes, see the preceeding entry, as well as pages 62, 65 and 95.

Catalog no. 2124, ISBN: 978-0-8493-2124-5 2006, 7 x 10, 4232 pp. Suggested Price: $229.95 / £125.00

Biomedical Nanotechnology Edited by

Neelina H. Malsch

Malsch TechnoValuation, Utrecht, The Netherlands

This cutting-edge work focuses on the biomedical applications of nanotechnology in three disciplines: nanodrugs and drug delivery; prostheses and implants; and diagnostics and screening technologies. Describing the nanotechnology applications associated with each, leading experts discuss recent research including their own, which involves gene therapy, cancer treatments, hip replacement coatings, cantilever biochemical sensors, and lab-on-a-chip techniques. Along with this technical discussion, Biomedical Nanotechnology presents an illuminating discourse on this technology, discussing potential and perceived risks, while also addressing the social and economic context of nanotech research. Catalog no. DK2453, ISBN: 978-0-8247-2579-2 2005, 6-1/8 x 9-1/4, 232 pp. Suggested Price: $144.95 / £79.99

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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Biomimetics Biomedical Photonics Handbook Edited by

Biologically Inspired Technologies Edited by

Duke University, Durham, North Carolina, USA

An authoritative source of reference for a broad audience, this handbook integrates interdisciplinary research and development on instrumentation, methods, and clinical applications of interest to scientists, engineers, manufacturers, teachers, students, and clinical providers. Editor-in-Chief Tuan Vo-Dinh and an advisory board of distinguished scientists and medical experts ensure that each of the 65 chapters represents the most accurate and modern information currently available. More than 150 scientists, engineers, and physicians discuss instrumentation, methods, and protocols, ensuring that readers have a comprehensive source for the latest research and applications. Catalog no. 1116, ISBN: 978-0-8493-1116-1 2003, 7 x 10, 1872 pp. Suggested Price: $229.95 / £128.00

Biomedical Technology and Devices Handbook Edited by

Jet Propulsion Laboratory, Pasadena, California, USA

This book examines pioneering methods in biomimetics. Introducing the principles of using biology to inspire designs as well as biological mechanisms as models for technology, this book surveys the field of biomimetics, from modeling to applications. Biomimetics: Biologically Inspired Technologies discusses the biological models useful to engineering, the current state of the field, and the progress and challenges awaiting future researchers. Taking a systems approach to design, it reflects the interdisciplinary nature of the science, integrating materials, structures, actuators, sensors, interfaces, control, adaptability, and intelligence, among others. Catalog no. 3163, ISBN: 978-0-8493-3163-3 2006, 7 x 10, 552 pp. Suggested Price: $164.95 / £92.00

Clinical Engineering Edited by

University of Houston, Texas, USA

Yadin David Wolf W. von Maltzahn Michael R. Neuman Joseph D. Bronzino

Series: Handbook Series for Mechanical Engineering, 12

Series: Principles and Applications in Engineering, 13

Concise yet comprehensive, the Biomedical Technology and Devices Handbook illuminates the equipment, devices, and techniques used in modern medicine to diagnose, treat, and monitor human illnesses. With topics ranging from the basic procedures like blood pressure measurement to cutting-edge imaging equipment, biological tests, and genetic engineering, the book is organized to navigate smoothly from simple procedures and concepts to more sophisticated and complex ones. Each section contains a description of the technique, its technical considerations, and its use according to its applications and relevant body systems. The book includes relevant web references, protocols, problems, and solutions.

Clinical Engineering focuses on managing the deployment of medical technology and integrating it appropriately with desired clinical practices. It provides a description of the wide range of responsibilities clinical engineers encounter, describes technology management and assessment in detail, and reviews the standards and regulatory agencies of interest. The book then examines various biomedical sensors, considering both biologic and electronic factors in sensor performance. Finally, the text covers bioinstrumentation, addressing traditional topics and recently developed instruments and devices such as pulse oximeters and home-care monitoring devices.

Catalog no. 1140, ISBN: 978-0-8493-1140-6 2004, 7 x 10, 840 pp. Suggested Price: $209.95 / £117.00

Catalog no. 1813, ISBN: 978-0-8493-1813-9 2003, 7 x 10, 432 pp. Suggested Price: $134.95 / £74.99

James Moore

Texas A&M University, College Station, USA

George Zouridakis

Biomedical Engineering

Yoseph Bar-Cohen

Tuan Vo-Dinh

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For more information and a complete list Computational Intelligence in Biomedical Engineering Rezaul Begg

Victoria University, Melbourne, Australia

Biomedical Engineering 70

Daniel T.H. Lai and Marimuthu Palaniswami

University of Melbourne, Australia

Handbook of Anatomical Models for Radiation Dosimetry Edited by

Xie George Xu

Rensselaer Polytechnic Institute, Troy, New York, USA

Keith F. Eckerman

Oak Ridge National Laboratory, Tennessee, USA

In recent years, there has been an explosion of interest in computational intelligence (CI) techniques as evidenced by numerous applications in various fields. Biomedical research and applications have benefited enormously as a result of applications of such tools and techniques. However, most of the scientific literature on the application of CI for modeling and pattern recognition is scattered in different journals and conference proceedings. Computational Intelligence in Biomedical Engineering provides a comprehensive account of the recent research efforts in this emerging area. In a single volume, it brings together cutting-edge research and applications of computational intelligence.

Covering the 40-year history of human model development, the Handbook of Anatomical Models for Radiation Dosimetry presents all of the major anatomical and physical models that have been developed for human body radiation protection, diagnostic imaging, and nuclear medicine therapy. This comprehensive reference explores how these models have evolved over time and the role that modern technology has played in this development. In addition, it evaluates the specific strengths of each model, discusses the wide range of applications available for these models, and addresses technical aspects of human modeling and computer simulations. The book also covers external radiation treatment.

Catalog no. 4080, ISBN: 978-0-8493-4080-2 2008, 6-1/8 x 9-1/4, 392 pp. Suggested Price: $134.95 / £74.99

Catalog no. C5979, ISBN: 978-1-4200-5979-3 June 2009, 7 x 10, 576 pp. Suggested Price: $129.95 / £78.99

Textbook

Handbook of Optical Sensing of Glucose in Biological Fluids and Tissues

Engineering Genetic Circuits

Edited by

Chris J. Myers

Valery V. Tuchin

Series: Chapman & Hall/CRC Mathematical & Computational Biology

Series: Series in Medical Physics and Biomedical Engineering

This book explores the key steps involved in systems biology. It introduces basic biochemistry principles underpinning the study of genetic circuits and presents one of the best understood circuits from the phage virus, which is used as an example throughout the text. The author then turns to modern experimental techniques and methods for developing genetic circuit models using experimental data. He also examines particular methods for the analysis of genetic circuit models, from stochastic analysis to deterministic differential equation models. The book concludes with the design of synthetic genetic circuits using those models.

With an extensive list of references on glucose sensing, glucose monitoring, and light-tissue interaction, this handbook analyzes trends in noninvasive optical glucose sensing and discusses its impact on tissue optical properties. It presents an up-to-date review of commercialized glucose sensors and the underlying science behind their functionality, discusses the fundamentals and basic research of light-tissue interaction, and describes biological fluids that contain glucose on physiological and hyperphysiological levels. The book also details new optical techniques for glucose diffusion coefficient measurements in human tissues and explains glucoseinduced optical clearing effects in tissue and blood.

University of Utah, Salt Lake City, USA

Catalog no. C3244, ISBN: 978-1-4200-8324-8 July 2009, 6-1/8 x 9-1/4, 300 pp. Suggested Price: $69.95 / £42.99

Saratov State University, Russia

Catalog no. C9748, ISBN: 978-1-58488-974-8 January 2009, 6-1/8 x 9-1/4, 744 pp. Suggested Price: $129.95 / £72.99

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Intelligent and Adaptive Systems in Medicine Edited by

Olivier C. L. Haas

Textbook

An Introduction to Biomedical Optics R. Splinter

Coventry University, UK Coventry University, UK

B.A. Hooper

Series: Series in Medical Physics and Biomedical Engineering

Series: Series in Optics and Optoelectronics, 3

This book clearly and concisely explains a range of adaptive and intelligent systems, highlighting their benefits and limitations with realistic medical examples. It illustrates how these systems can be used in all stages of medical treatment. Each chapter presents an intelligent and adaptive system, explains the techniques and algorithms behind the system, and explores how to solve medical and biomedical problems using the system. The book focuses on the tools of fuzzy logic, artificial neural networks, neuro-fuzzy modeling, adaptive and predictive control, systems and statistical modeling, and image processing. Catalog no. IP385, ISBN: 978-0-7503-0994-3 2008, 6-1/8 x 9-1/4, 400 pp. Suggested Price: $149.95 / £83.00

Areté Associates, Arlington, Virginia, USA

This is the first comprehensive, introductory book describing both diagnostic and therapeutic optical methods in medicine. The first section covers the history of optics theory and the basic science behind light-tissue interactions. It also introduces the relevant approaches and approximations used to describe light propagation in turbid biological media. In the second section, the authors look more closely at light-tissue interactions and their applications in different medical areas, such as wound healing and tissue welding. The final section examines the various diagnostic methods that are employed using optical techniques. Throughout, the text employs numerical examples of clinical and research requirements.

Biomedical Engineering

University of North Carolina at Charlotte, USA

Keith J. Burnham

Catalog no. IP128, ISBN: 978-0-7503-0938-7 2007, 6-1/8 x 9-1/4, 632 pp. Suggested Price: $83.95 / £38.99

Textbook

Introduction to Molecular Biology, Genomics and Proteomics for Engineers

Textbook

Introduction to Biomedical Engineering Technology

Robert B. Northrop

University of Connecticut, Storrs, USA

Laurence J. Street

Chilliwack General Hospital, Rosedale, British Columbia, Canada

Anne N. Connor

Providing the information that students and practitioners need to function effectively in a variety of healthcare settings, Introduction to Biomedical Engineering Technology describes current technological devices, the physiological and anatomical basis of their function, their practical applications, and their common locations in hospitals. The text also discusses tools and test equipment, examines the integration of equipment within the hospital system, and presents an overview of various kinds of hardware related to medical equipment. Each chapter includes a summary, questions, and suggestions for further reading.

An introductory text, this book has been written for engineers and scientists who have not studied molecular biology, genomics, and proteomics, and who are working with, or planning to work with, living systems. The authors assume readers are familiar with basic calculus, physics, and linear algebra. They describe the very complex biochemical relations that permit life to exist, highlighting the specialized organic molecules in living organism, and how they interact and react. This is a primer, not intended as an academic short-cut or a replacement for formal, in-depth course work, but intended to broaden the background and pique the interest of undergraduate students.

Catalog no. 8533, ISBN: 978-0-8493-8533-9 2008, 6-1/8 x 9-1/4, 344 pp. Suggested Price: $83.95 / £46.99

University of Connecticut, Storrs, USA

Catalog no. 61194, ISBN: 978-1-4200-6119-2 January 2009, 7 x 10, 480 pp. Suggested Price: $99.95 / £44.99

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For more information and a complete list Textbook

An Introduction to Rehabilitation Engineering Edited by

Textbook

Medical Physics and Biomedical Engineering

Biomedical Engineering

Rory A. Cooper , Hisaichi Ohnabe and Douglas A. Hobson University of Pittsburgh, Pennsylvania, USA

B.H. Brown, R.H. Smallwood, D.C. Barber, P.V. Lawford, and D.R. Hose

Series: Series in Medical Physics and Biomedical Engineering

This resource focuses on the principles, modeling, standards, devices, and technologies of rehabilitation engineering and assistive technology. It describes numerous design models and processes, including participatory action design and service delivery models. The book also discusses the components of devices such as cushions, wheelchairs, prostheses, orthoses, hearing aids, and TTYs. The contributors assess industry standards and explore innovative technology aids, such as sensors, robot-assisted therapy, and speech recognition software. The text contains a set of learning objectives and study questions in each chapter as well as a list of definitions at the end of the book.

Appropriate for senior undergraduates and graduates, this text presents the underlying physics, electronics, anatomy, and physiology and addresses practical applications. The structured approach of the text builds and broadens the material of opening chapters in the later chapters. The book covers biomechanics, image formation techniques, biomedical devices, physiological signals and responses, and respiratory and cardiovascular function and measurement. It includes chapter problems with short questions to test understanding of the main principles and longer questions to test more in-depth knowledge, along with detailed bibliographies that provide references to introductory texts and research materials.

Catalog no. IP834, ISBN: 978-0-8493-7222-3 2007, 6-1/8 x 9-1/4, 472 pp. Suggested Price: $73.95 / £40.99

Catalog no. IP447, ISBN: 978-0-7503-0368-2 1998, 7 x 10, 768 pp., Soft Cover Suggested Price: $93.95 / £48.99

Medical Modelling

The Application of Advanced 72 Design and Development Techniques in Medicine Edited by

Mobile Telemedicine A Computing and Networking Perspective Edited by

Yang Xiao

The University of Alabama, Tuscaloosa, USA

Richard Bibb

Hui Chen

Providing a source of information relating to the technological challenges and solutions encountered in the accurate capture of anatomical data, this book covers computer-aided techniques and physical replication as used in a variety of medical disciplines. It comprehensively reviews the state of the art in the application of advanced design and development technologies in medicine. It also includes a reference source of peer-reviewed case studies describing the practical application of anatomical scanning, computer-aided design (CAD), rapid prototyping (RP), and computer-aided manufacturing (CAM) techniques in a broad range of research, medical, and surgical applications.

Advances in the area of wireless and mobile telemedicine to diagnose and treat patients have drawn growing attention from healthcare providers and recipients, industry, researchers, and governments. This volume examines computing and network dilemmas which arise from wireless and mobile telemedicine. Comprised of the contributions of many prominent international researchers, the book gives an overview of patient care and monitoring, discusses the use of telemedicine in cardiology and diabetes, analyzes security and privacy considerations, examines issues relating to networking support, and concludes with a section on the opportunities and challenges that are faced by those involved in this exciting technology.

Catalog no. WP9106, ISBN: 978-0-8493-9106-4 2007, 6 x 9, 297 pp. Suggested Price: $239.95 / £133.00

Catalog no. AU6046, ISBN: 978-1-4200-6046-1 2008, 6-1/8 x 9-1/4, 440 pp. Suggested Price: $79.95 / £44.99

University of Wales, UK

Virginia State University, Petersburg, USA

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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Optimization in Medicine and Biology

Monitoring of Respiration and Circulation

Edited by

Gino J. Lim

Eindhoven University of Technology, The Netherlands

Eva K. Lee

There are books covering medical instrumentation, modeling, physiological models, and signal processing, but this is the first to offer a broad integration of all these subjects. Monitoring of Respiration and Circulation provides a survey of the field, a review of the necessary fundamentals on which deeper study can be based, and an overview of possible search terms. The early chapters refresh and deepen knowledge and introduce modeling. The middle chapters describe important clinical measurement methods and the information they provide about a patient, including approaches, possibilities, limitations and accuracies. Finally, the book discusses clinical therapeutic instruments.

Integrating foundational theory, modeling techniques, algorithms, and applications, this comprehensive reference highlights the recent advances in optimization techniques for solving complex problems in medical and biological research. It discusses mathematical programming techniques for medical decision-making processes and applies them to pediatric vaccine formularies, cancer treatment planning models, and the cost-effectiveness of HIV programs. It also examines optimization in biology and discusses algorithms for genomic analysis; probe design and selection; and algorithms and software packages to aid in probe selection and design. The appendix provides a tutorial on Integer Programming (IP).

Catalog no. 2083, ISBN: 978-0-8493-2083-5 2004, 6-1/8 x 9-1/4, 200 pp. Suggested Price: $104.95 / £57.99

Catalog no. AU0563, ISBN: 978-0-8493-0563-4 2008, 6-1/8 x 9-1/4, 592 pp. Suggested Price: $149.95 / £83.00

Neuroengineering

Georgia Institute of Technology, Atlanta, USA

Pervasive Computing in Healthcare Edited by

Jakob E. Bardram

Edited by

IT University of Copenhagen, Denmark

Daniel J. DiLorenzo

Biomedical Engineering

University of Houston, Texas, USA

J.A. Blom

DiLorenzo Biomedical, LLC, Houston, Texas, USA

Alex Mihailidis

Joseph D. Bronzino

Dadong Wan

Trinity College, Hartford, Connecticut, USA

Accenture Technology Labs, Chicago, Illinois, USA

Comprehensive, practical, and broad in scope, Neuroengineering offers clinical insights on revolutionary technologies from prominent neurosurgeons and neurologists. This book presents a wide range of new developments in the field and high-impact emerging technologies poised to change the industry, described in detail by the experts who invented them. It provides a thorough understanding of the fundamental science and technology behind neural modulation and neurophysiology. Including features that make it a great reference for students, this book also includes more than 150 figures that allow readers to visualize the anatomy, technologies, and surgical procedures discussed in the text.

With a holistic view, Pervasive Computing in Healthcare offers an overview of the subject and its application to problems in healthcare and disability. This book covers the basics, including various types of computer science tools and techniques, and introduces important models in applying technology to healthcare, disease, and disability. It presents specific examples of pervasive computing applications in various contexts, such as in the home or in the hospital, and describes how it can be applied as proactive or preventative methods to help with diseases. This text also provides an understanding of research and methodological issues related to developing technologies and evaluating their performance.

Catalog no. 8174, ISBN: 978-0-8493-8174-4 2008, 7 x 10, 408 pp. Suggested Price: $93.95 / £51.99

Catalog no. 3621, ISBN: 978-0-8493-3621-8 2007, 6-1/8 x 9-1/4, 336 pp. Suggested Price: $144.95 / £79.99

University of Toronto, Ontario, Canada

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For more information and a complete list

Polyolefin Fibres

Industrial and Medical Applications S.C.O. Ugbolue

Biomedical Engineering 74

A Short Introduction to Biomedical Engineering

The Hong Kong Polytechnic University, Hong Kong University of Massachusetts, USA

S.N. Sarbadhikari

Polyolefins are among the most widely used commercial polymers. These versatile fibers are durable, chemically resistant, lightweight, economical, and functional. This work provides researchers in materials, as well as product development specialists in industry and biomedical engineering with a comprehensive resource that will assist them with material improvement and product development. The first chapters discuss the structural and chemical properties of different types of polyolefins, as well as production methods. Middle chapters delve into functionality improvement. The final sections address how polyolefins can be incorporated into specific industrial, medical, and automotive products.

Presenting a bird’s eye view of the important components in biomedical engineering, this book explores how bioengineering has emerged as an important aid to diagnosis, therapy, and rehabilitation. The author discusses the application of electrical, mechanical, chemical, optical, and other engineering principles to understand, modify or control biological systems. He covers the design and manufacture of products for monitoring physiological functions, assisting in diagnoses, assessing prognoses, and helping in treatment of patients. It also provides a glimpse of emerging trends in biomedical engineering like telemedicine and the wider use of computers in health care.

Catalog no. N10000, ISBN: 978-1-4200-9985-0 April 2009, 6 x 9, 320 pp. Suggested Price: $239.95 / £125.00

Catalog no. UN6011, ISBN: 978-1-4200-6011-9 2008, 276 pp. Suggested Price: $41.95 / £22.99

Shape Memory Alloys for Biomedical Applications

Tunable Laser Applications

Edited by

Amrita Vishwa Vidyapeetham; AIMS; Kochi, India

Second Edition Edited by

T. Yoneyama

Nihon University, Chiyoda-ku, Tokyo

F.J. Duarte

S. Mayazaki

Interferometric Optics, Rochester, New York, USA

University of Tsukuba, Japan

Series: Optical Science and Engineering

Shape memory alloys are suitable for a wide range of biomedical applications, such as dentistry, bone repair and cardiovascular stents. Shape Memory Alloys for Biomedical Applications provides a comprehensive review of the use of shape memory alloys in these and other areas of medicine. Part One discusses fundamental issues with chapters on such topics as mechanical properties, fabrication of materials, the shape memory effect, superelasticity, surface modification and biocompatibility. Part Two covers applications of shape memory alloys in areas such as stents and orthodontic devices as well as other applications in the medical and dental fields.

With an emphasis on biological and medical applications, the second edition of Tunable Laser Applications reflects the significant developments in tunable lasers and tunable laser applications that have taken place over the past decade. Written by leading international experts, this edition covers various types of tunable laser sources, including tunable semiconductor lasers, solid-state dye lasers, fiber lasers, table-top lasers, free-elctron lasers, and interferometric imaging-based lasers. It also provides a practical overview of a wide range of scientific applications for in the biological and medical fields, including MEMS and x-ray imaging.

Catalog no. WP9303, ISBN: 978-1-4200-9303-2 January 2009, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $239.95 / £133.00

Catalog no. 60279, ISBN: 978-1-4200-6009-6 January 2009, 6-1/8 x 9-1/4, 480 pp. Suggested Price: $149.95 / £83.00

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Data, Equations, and Their Practical Uses

Biomedical Image Analysis

Edited by

Dale Ensminger

Rangaraj M. Rangayyan

Sunnyvale, California, USA

Foster B. Stulen

University of Calgary, Alberta, Canada

Ethicon Endo-Surgery, Ohio, USA

Series: Biomedical Engineering, 10

A unique treatment, Ultrasonics presents data and functions gathered from several areas of science and technology. It provides coverage ranging from sensors to systems across the spectrum from industrial to medical, and both low and high power. The book evaluates the practicality of new ideas and explores how to make important data available for the design of ultrasonic systems to meet present and new developments, including applications in standard and harsh environments. Additional coverage includes design equations, piezoelectric materials, magnetostrictive transducer design data, materials evaluation, and mechanical effects of ultrasonic energy.

Biomedical Image Analysis demonstrates the benefits reaped from the application of digital image processing, computer vision, and pattern analysis techniques to biomedical images. These include the improvement of diagnostic confidence through quantitative analysis. The book focuses on post-acquisition challenges including image enhancement, detection of edges and objects, analysis of shape, quantification of texture and sharpness, and pattern analysis. Each chapter addresses several problems associated with imaging or image analysis, outlining the typical processes and then detailing more sophisticated methods directed to the specific problems of interest.

Catalog no. DK8307, ISBN: 978-0-8247-5830-1 January 2009, 6-1/8 x 9-1/4, 508 pp. Suggested Price: $139.95 / £77.99

Automated Image Detection of Retinal Pathology Herbert Jelinek

Charles Sturt University, Albury, NSW, Australia

Michael J. Cree

Catalog no. 9695, ISBN: 978-0-8493-9695-3 2005, 6-1/8 x 9-1/4, 1312 pp. Suggested Price: $104.95 / £57.99

Biomedical Engineering / Biomedical Imaging

Ultrasonics

Biomedical Imaging in Experimental Neuroscience Edited by

Nick van Bruggen

Genentech Incorporated, San Francisco, California, USA

Timothy Roberts

University of Toronto, Ontario, Canada

University of Waikato, Hamilton, New Zealand

Series: Frontiers in Neuroscience, 18

Providing background on the impact of eye disease on the community, Automated Image Detection of Retinal Pathology discusses the effect of automated assessment programs on health care provision. This book offers examples and analyzes the use of automated computer techniques, such as pattern recognition, in detecting retinal images as well as diabetic retinopathy. Addressing the benefits and challenges of automated health care in the field of ophthalmology, it details the increasing practice of telemedicine screening along with other advanced applications including arteriolar-venous ration, which has been shown to be an early indicator of cardiovascular, diabetes, and cerebrovascular risk.

With the emergence of genetically-manipulated laboratory mice as one of the most powerful tools for neuroscientists, imaging techniques capable of providing anatomical and functional information of small animals have become extremely important. Emphasizing data analysis and interpretation, Biomedical Imaging in Experimental Neuroscience presents a comprehensive review of the noninvasive biomedical imaging techniques available for laboratory animal research. It covers the scope and limitations of these methods and analyzes their impact on in vivo neuroscience research. The book also provides a concise theoretical description of the pertinent physics.

Catalog no. 7556, ISBN: 978-0-8493-7556-9 July 2009, 6 x 9, 400 pp. Suggested Price: $139.95 / £85.00

Catalog no. 0335, ISBN: 978-0-8493-0122-3 2003, 6-1/8 x 9-1/4, 368 pp. Suggested Price: $159.95 / £92.00

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For more information and a complete list Color Image Processing

Textbook

Biosignal and Biomedical Image Processing John L. Semmlow

Biomedical Imaging 76

Methods and Applications Edited by

Rastislav Lukac

Epson Edge, Epson Canada Ltd., Ontario, Canada

Rutgers University, Piscataway, New Jersey, USA

Konstantinos N. Plataniotis

Series: Signal Processing and Communications, 22

Image Processing Series, 7

University of Toronto, Ontario, Canada

Relying heavily on MATLAB problems and examples as well as on simulated data, this text surveys a vast array of signal and image processing tools for biomedical applications, providing a working knowledge of the technologies addressed while showcasing valuable implementation procedures, common pitfalls, and essential application concepts. The first textbook to supply a hands-on tutorial in biomedical signal and image processing, it offers a unique and proven approach to signal processing instruction, unlike any other competing source on the topic. The text is accompanied by a CDROM with support data files and software including all MATLAB examples and figures found in the text.

With advances in image sensors, digital TV, image-enabled consumer electronics, and much more, color image processing is of paramount interest in the computer vision community. This book details recent advances in digital color image acquisition, analysis, processing, and display, exploring emerging color image, video, multimedia, and biomedical processing applications. It examines the latest techniques, algorithms, and solutions for digital color imaging, emphasizing emerging topics such as secure imaging, semantic processing, and digital camera image processing. In addition, the text comprehensively covers the system design, implementation, and application aspects of digital color imaging.

Catalog no. DK1299, ISBN: 978-0-8247-4803-6 2004, 6 x 9, 448 pp. Suggested Price: $104.95 / £57.99

Catalog no. 9774, ISBN: 978-0-8493-9774-5 2007, 7 x 10, 600 pp. Suggested Price: $154.95 / £86.00

Textbook

Computational Intelligence in Medical Imaging

Biosignal and Medical Image Processing Second Edition

Techniques and Applications Edited by

G. Schaefer

Aston University, Birmingham, UK

John L. Semmlow

A. Hassanien

Series: Signal Processing and Communications, 22

J. Jiang

This second edition of a popular volume provides a complete set of signal processing tools including diagnostic decision-making tools and classification methods. New chapters cover adaptive neural nets, linear discriminators, and support vector machines. Examples and problems in MATLAB® encourage exploration of important properties of signal and image processing tools. An accompanying CD-ROM features data, support subroutines, and source code from examples in the text. An educational support CD-ROM that contains a solutions manual, a suggested syllabus, and PowerPoint® presentations of all chapters is also available for qualified instructors.

Operating at the intersection of computer science and diagnostic radiology, medical imaging continues to evolve with new modalities and improved devices, many of these based on artifical intelligence. This work provides an authoritative source of research and methodology in soft computing as it relates to imaging. The book presents developments in image visualization, and imageguided procedures authored by pioneers in the field. It also covers the physics of imaging; the physiology of medical images; image processing; imaging informatics; and ultrasonic signal processing. In addition, the editors include disucssions on clinical decision making, artificial intelligence in medical education, and medical knowledge engineering.

Rutgers University, Piscataway, New Jersey, USA

Catalog no. 62301, ISBN: 978-1-4200-6230-4 January 2009, 7 x 10, 472 pp. Suggested Price: $99.95 / £39.99

Kuwait University, Safat University of Bradford, West Yorkshire, UK

Catalog no. C6059, ISBN: 978-1-4200-6059-1 March 2009, 6-1/8 x 9-1/4, 464 pp. Suggested Price: $99.95 / £60.99

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Textbook

Fundamentals of MRI An Interactive Learning Approach

Computerized Tomography for Scientists and Engineers

Elizabeth Berry

Elizabeth Berry Ltd, Leeds, UK

Andrew Bulpitt

Prabhat Munshi

Series: Series in Medical Physics and Biomedical Engineering

This volume provides examples of applications of tomography in engineering from leading CT experts. Typical problems include monitoring of multiphase flows, crystal growth, blast furnaces, stirred vessels, non-destructive testing, plasma diagnostics, and determining the strength of bones. X and Y- rays, electrical impedance and resistance measurements, ultrasound, and lasers are all covered. Various mathematical issues are addressed as are various physical problems. As the book provides an account of current developments in imaging, it is quite useful applied to other fields where identical mathematical techniques are employed. Imaging has evolved into an interdisciplinary field with mathematics as a common language.

Covering all the basics, this self-contained introduction explores the physical principles that underpin the technique of MRI. It links key principles to the main components of an MRI system, such as radio frequency coils and gradient coils, and outlines the steps of spatial localization: slice selection, frequency encoding, and phase encoding. The text also illustrates how an image is generated. The authors integrate exercises and detailed solutions within the text, include 150 multiple-choice questions with answers in the back of the book, and provide a CD-ROM with worked examples, animations, exercises, and interactive programs.

Indian Institute of Technology, Kanpur, India

Catalog no. AN4793, ISBN: 978-1-4200-4793-6 2007, 7 3/8 x 9 1/4, 240 pp. Suggested Price: $124.95 / £69.99

Diagnostic Ultrasound

Imaging and Blood Flow Measurements K. Kirk Shung

Biomedical Imaging

University of Leeds, School of Computing, Leeds, UK

Edited by

Catalog no. C9012, ISBN: 978-1-58488-901-4 January 2009, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $59.95 / £33.99

The Image Processing Handbook

Fifth Edition

University of Southern California, Los Angeles, USA

John C. Russ

Keeping mathematical derivations to a minimum, Diagnostic Ultrasound: Imaging and Blood Flow Measurements begins with an overview of the field, the strengths and weaknesses of the technology, and its role relative to other imaging modalities. The focus then moves to the fundamental physics involved, a detailed discussion of the transducer, conventional imaging approaches, and Doppler measurements. The next chapters explore new developments such as flow, displacement, contrast, harmonic, intracavity, and 4-D imaging. The author concludes by reviewing current status and standards on bioeffects along with a unique chapter on measuring ultrasonic properties of tissues that can be found nowhere else.

Image processing is used in a wide variety of applications to improve the visual appearance of images and to prepare images for measurement. Covering techniques for both tasks, this best-selling handbook presents an extensive collection of image processing tools to help readers understand methods used in packaged software and learn to program additions for applications. With more than 600 new and revised illustrations, this edition expands discussions on deconvolution, extended dynamic range images, and multichannel imaging with new material on principal components analysis. It also includes a new chapter on human vision and discusses the latest technologies for image capture and printing.

Catalog no. DK1305, ISBN: 978-0-8247-4096-2 2006, 6-1/8 x 9-1/4, 232 pp. Suggested Price: $124.95 / £69.99

Catalog no. 7254, ISBN: 978-0-8493-7254-4 2007, 7 x 10, 832 pp. Suggested Price: $164.95 / £92.00

North Carolina State University, Raleigh, USA

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For more information and a complete list Textbook

Image Processing with MATLAB® Omer Demirkaya

Medical Image Processing, Reconstruction and Restoration

Musa Hakan Asyali

Jiˇrí Jan

Erciyes University, Kayseri, Turkey

Brno University of Technology, Czech Republic

Prasanna K. Sahoo

University of Louisville, Kentucky, USA

Series: Signal Processing and Communications, 25

This text explains complex, theory-laden topics in image processing through examples and MATLAB® algorithms. It provides these algorithms to help scientists and researchers quickly identify the most effective solution method for a particular problem at hand. The authors emphasize three-dimensional processing and analysis as well as statistical and stochastic modeling. They cover the new areas of nonlinear diffusion filtering and PDE-based image filtering, address relatively advanced topics, such as Markov random fieldbased image segmentation, and highlight applications with images from medicine and biology. They also include real-world examples and exercises in every chapter.

Development of new medical image processing methods and the interpretation of complicated results require deep understanding of the underlying theory and methods involved in image processing and analysis. This text provides a firm grounding in the principles and insight into the way of treating the image material. It demonstrates consistent reasoning based on a firm grasp of image processing fundamentals, favoring continuous, understandable explanation over strict mathematical formalism. The author first considers images as multidimensional signals, then as data sources, and finally delves into individual image processing topics such as tomographic image reconstruction and image fusion.

Catalog no. 9246, ISBN: 978-0-8493-9246-7 January 2009, 6-1/8 x 9-1/4, 468 pp. Suggested Price: $99.95 / £42.99

Catalog no. DK1212, ISBN: 978-0-8247-5849-3 2006, 6 x 9, 760 pp. Suggested Price: $164.95 / £92.00

Applications in Medicine and Biology King Faisal Specialist Hospital & Res. Ctr, Riyadh, Saudi Arabia

Biomedical Imaging 78

Medical Image Analysis Methods

Concepts and Methods

Medical Image Registration Edited by

Joseph V. Hajnal

Edited by

Lena Costaridou

Hammersmith Hospital, London, UK

University of Patras, Greece

Derek L.G. Hill and David J. Hawkes

Electrical Engineering & Applied Signal Processing Series, 18

Series: Biomedical Engineering, 5

Medical Image Analysis Methods details the primary methods, techniques, and approaches used to improve the quality of visually perceived images as well as quantitative detection and diagnostic decision aids. This comprehensive volume illustrates analytical techniques such as computer-aided diagnosis (CAD), adaptive wavelet image enhancement, and data-driven optimized image segmentation and registration. Paradigms of the analysis methods used in bioinformatics and neurosciences are also provided in respective chapters. In addition, this reference reviews techniques that are used to evaluate these major medical-image processing and analysis methods. Catalog no. 2089, ISBN: 978-0-8493-2089-7 2006, 6-1/8 x 9-1/4, 504 pp. Suggested Price: $175.95 / £98.00

Guy’s Hospital, London, UK

This reference details the theory, technology, and practical implementations of image registration in a variety of medical settings. International experts thoroughly explain why image registration is important, describe its applications in a nonmathematical way, and provide rigorous analysis for those who plan to implement algorithms themselves. It is accessible and informative to those new to the field, yet it provides in-depth treatment for the expert. With its practical examples, extensive illustrations, and comprehensible approach, Medical Image Registration is a must-have guide for medical physicists, clinicians, and researchers. Catalog no. 0064, ISBN: 978-0-8493-0064-6 2001, 6-1/8 x 9-1/4, 392 pp. Suggested Price: $124.95 / £69.99

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Medical Infrared Imaging

Molecular and Cellular MR Imaging

Edited by

Nicholas A. Diakides

Michel M.J. Modo

Joseph D. Bronzino

Trinity College, Hartford, Connecticut, USA

Edited by the inventor of the MedATR concept that lead to the first IR-CAD for the early detection of breast cancer, Medical Infrared Imaging presents many of the concepts and technologies that are key to the acceptance of infrared imaging as a non-invasive, low-cost, first-line detection modality. Presenting revolutionary advances and their medical applications, the book examines the resulting technology and hardware. It covers the fundamentals of thermal imaging, novel processing techniques, and new applications in diagnostics and therapeutic monitoring. The text emphasizes the importance of standardization, calibration, and protocols; databases for storage and retrieval of images; and ethical obligations. Catalog no. 9027, ISBN: 978-0-8493-9027-2 2008, 7 x 10, 448 pp. Suggested Price: $93.95 / £51.99

MicroComputed Tomography

University of London, Dept. of Psychiatry, UK

Jeff W.M. Bulte

Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

In this book, the editors bring together a select group of internationally recognized authors, each drawing on their specific expertise, to highlight the diversity of skills necessary for the effective utilization and advancement of molecular and cellular imaging. The book provides a state-of-the-science overview of the various approaches that have been used to visualize cells and molecules by MR imaging and illustrates their application and translation into clinical settings. It examines the various contrast agents used, covers molecular imaging of genes and a range of disease states, discusses cellular imaging, and presents the future directions of the field.

Biomedical Imaging

Advanced Concepts Analysis, Inc., Falls Church, Virginia, USA

Catalog no. 2526, ISBN: 978-0-8493-7252-0 2007, 7 x 10, 440 pp. Suggested Price: $175.95 / £98.00

Methodology and Applications

Optical Imaging Techniques in Cell Biology

Stuart R. Stock

Guy Cox

Northwestern University, Evanston, Illinois, USA

University of Sydney, New South Wales, Australia

Due to the availability of commercial laboratory systems and the emergence of user facilities at synchrotron radiation sources, studies of microcomputed tomography (or microtomography) have increased exponentially. MicroComputed Tomography provides a complete introduction to microCT, describing how to use this technique effectively and how to understand its results. The first part of the book focuses on methodology, covering experimental methods, data analysis, and visualization approaches, while the second part addresses various microCT applications, including porous solids, microstructural evolution, soft tissue studies, multimode studies, and indirect analyses.

Covering the basics of optical microscopy, as well as recent techniques such as fluorescent lifetime imaging and Förster resonance energy transfer, Optical Imaging Techniques in Cell Biology serves as a comprehensive guide for researchers and students. The author, a renowned scientist known internationally as an instructor in optical imaging, employs a highly accessible and uniform style. He discusses basic microscopes and their underlying principles, image optimization, and extensions to the confocal principle, including their value to the biologist. He also covers advanced techniques such as deconvolution and fluorescent probes, and offers a preview of future imaging tools and techniques.

Catalog no. 58762, ISBN: 978-1-4200-5876-5 January 2009, 6-1/8 x 9-1/4, 336 pp. Suggested Price: $129.95 / £72.99

Catalog no. 3919, ISBN: 978-0-8493-3919-6 2007, 6-1/8 x 9-1/4, 288 pp. Suggested Price: $144.95 / £79.99

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For more information and a complete list

Photoacoustic Imaging and Spectroscopy Biomedical Imaging / Biophysics

Edited by

Lihong Wang

Washington University, St. Louis, USA Series: Optical Science and Engineering, 144

Second Edition

Cynthia Furse, Douglas A. Christensen, and Carl H. Durney

University of Utah, Salt Lake City, USA

Photoacoustic imaging combines electromagnetic and ultrasonic waves to provide deep speckle-free imaging with high electromagnetic contrast at a high resolution. By means of spectroscopy, photoacoustics can also provide functional sensing of physiological parameters such as the oxygen saturation of hemoglobin. This book presents the state of the art in this exciting new area of research, offering complete coverage of photoacoustic, optoacoustic, and thermoacoustic imaging. Featuring 200 illustrations, the text compares x-ray and ultrasonic images with photoacoustic images. It also discusses all potential applications of photoacoustic technology, including biomedical applications.

Completely revised and updated, Basic Introduction to Bioelectromagnetics facilitates the process of interdisciplinary research by introducing life scientists to the basic concepts of electromagnetic fields. This new edition outlines elements of EM that are helpful to life scientists working with physicists and electrical engineers. Each concept is presented with an associated application and discussion. Example applications include MRI, NMR, ultrasound, hyperthermia, neural stimulation, and cardiac pacing/ defibrillation. With the liberal use of diagrams and graphs, this text covers the entire frequency spectrum through optical frequencies from a qualitative perspective beneficial to life scientists.

Catalog no. 59912, ISBN: 978-1-4200-5991-5 March 2009, 8-1/2 x 11, 492 pp. Suggested Price: $149.95 / £89.00

Catalog no. 55429, ISBN: 978-1-4200-5542-9 January 2009, 7 x 10, 288 pp. Suggested Price: $99.95 / £60.99

Textbook

Basic Introduction to Bioelectromagnetics

A Practical Approach to Medical Image Processing Elizabeth Berry

Elizabeth Berry Ltd, Leeds, UK

Bioeffects and Therapeutic Applications of Electromagnetic Energy

Series: Series in Medical Physics and Biomedical Engineering

Riadh W.Y. Habash

Using an interactive workbook approach to introduce the concept in a nonmathematical way, A Practical Approach to Medical Image Processing explains the techniques through worked examples, exercises, and problems and validates each technique with a corresponding case study, which originates from a published journal article. The examples and exercises are supplied on an accompanying CD-ROM that uses well-known, readily available software such as the software package ImageJ. With an emphasis on the effects of a technique on an image, this text provides a thorough understanding of medical image processing that allows readers to make a reasoned choice of method.

Taking a multidisciplinary approach drawn from several different intellectual streams that include physics, epidemiology, medicine, environment, risk assessment, and various disciplines of engineering, this book ventures into three main areas related to bioeffects and therapeutic applications of EM energy. First, it provides a review of cutting-edge research in EM health effects as well as risk assessment of low frequency fields and radio frequency radiation. Second, it addresses standards and protection guidelines related to EM human exposure. Finally, it highlights recent advances in therapeutic applications of EM energy, EM and thermal dosimetry, and imaging techniques.

Catalog no. C8245, ISBN: 978-1-58488-824-6 2008, 6-1/8 x 9-1/4, 304 pp. Suggested Price: $83.95 / £39.99

Catalog no. 62840, ISBN: 978-1-4200-6284-7 2008, 6-1/8 x 9-1/4, 400 pp. Suggested Price: $144.95 / £79.99

University of Ottawa, Ontario, Canada

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Textbook

Biomolecular Action of Ionizing Radiation Shirley Lehnert

Montreal General Hospital/McGill University, Canada

Two-Volume Set, Third Edition Edited by

Frank S. Barnes, University of Colorado, Boulder, USA Ben Greenebaum, University of Wisconsin, Kenosha, USA Entering its third edition, the bestselling Handbook of Biological Effects of Electromagnetic Fields is the definitive reference for researching bioeffects of static, low-, and high-frequency fields. It incorporates extensive new material and up-to-date data, results, and discussions into two cohesive volumes.

Order the set and save!

Raising the standard for radiation biology textbooks, this graduatelevel text offers an up-to-date analysis of molecular responses in the body induced by ionizing radiation. It presents an in-depth perspective on clinical applications for the treatment of cancer and radiation injuries. Based on a popular course at McGill University, the book clarifies the underlying mechanisms of radiation effects on signal transduction pathways using terms that non-experts in molecular biology can understand. With an emphasis on medical physics, it relates principles of radiobiophysics and key advances with potential applications of ionizing radiation for diagnosis and treatment.

Biophysics

Handbook of Biological Effects of Electromagnetic Fields

Series: Series in Medical Physics and Biomedical Engineering

Catalog no. IP164, ISBN: 978-0-7503-0824-3 2008, 6-1/8 x 9-1/4, 560 pp., Soft Cover Suggested Price: $83.95 / £44.99

Catalog no. 2952, ISBN: 978-0-8493-2952-4 2007, 7 x 10, 960 pp. Suggested Price: $154.95 / £86.00

Also available as individual volumes Suggested Price for each: $114.95 / £63.99

Bioengineering and Biophysical Aspects of Electromagnetic Fields This first volume discusses the physics, engineering, and chemical aspects of electromagnetic (EM) fields at both the molecular level and larger scales, and investigates their interactions with biological systems. It now includes material describing recent theoretical developments, as well as new data on material properties and interactions with weak and strong static magnetic fields. Catalog no. 9538, ISBN: 978-0-8493-9538-3, 480 pp.

Biological and Medical Aspects of Electromagnetic Fields Examining potential health hazards, exposure standards, and medical applications of electromagnetic (EM) fields, the second volume draws from the latest studies on the possible health effects of exposure to electric and magnetic fields. In addition to extensive reviews of physiological effects, it contains separate reviews of behavioral and cognitive responses to various exposures.

Coarse-Graining of Condensed Phase and Biomolecular Systems

Edited by

Gregory A. Voth

University of Utah, Salt Lake City, USA

Assembling some of the most influential, world-renowned researchers in the field, this book covers the latest developments in the coarsegrained molecular dynamics simulation and modeling of condensed phase and biomolecular systems. Each chapter focuses on specific examples of evolving coarse-graining methodologies and presents results for a variety of complex systems. The contributors discuss the minimalist, inversion, and multiscale approaches to coarse-graining, along with the emerging challenges. They also connect atomic-level information with new coarse-grained representations of complex systems, such as lipid bilayers, proteins, peptides, and DNA. Catalog no. 59556, ISBN: 978-1-4200-5955-7 January 2009, 7 x 10, 456 pp. Suggested Price: $159.95 / £89.00

Catalog no. 9539, ISBN: 978-0-8493-9539-0, 440 pp. Rest of the World Tel: +44 (0) 1235 400 524 • Fax: +44 (0) 1235 400 525 e-mail: (UK) uk.trade@tandf.co.uk • (International) international@tandf.co.uk

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For more information and a complete list Soft Condensed Matter Physics in Molecular and Cell Biology Edited by

Textbook

W.C.K. Poon

Edinburgh University, Scotland

Molecular and Cellular Biophysics

D. Dandelman

Jack A. Tuszynski

Scottish Graduate Series, Vol. 59

Series: Pure and Applied Physics

The focus of Soft Condensed Matter Physics in Molecular and Cell Biology is based on the poignant realization that biology is soft matter come alive. The chapters in this volume originated as lectures in the NATO Advanced Science Institute and Scottish Universities Summer Schools in Physics. The book provides a thorough grounding in the fundamental nature and properties of soft matter, and then explores its application in biology, especially with regard to DNA investigations, and the study of protein behavior. The final section of the book considers experimental techniques, covering single molecule force spectroscopy of proteins, the use of optical tweezers, and solution scattering.

Logically organized from small-scale to large-scale systems, this text provides comprehensive coverage of both molecular and cellular biophysics using a quantitative approach. It first discusses the characteristics of living things and the evolution of life. The book then covers small-scale structures that include DNA, RNA, and hydrogen bonds, followed by large-scale systems, such as basal bodies, mitochondria, and vesicles. The author also examines the biophysical processes of oxidative phosphorylation, diffusion, exciton energy transfer, and cell division. In addition, the text includes numerous worked examples, exercises, references, and illustrations.

Catalog no. IP658, ISBN: 978-0-7503-1023-9 2006, 6 1/8 x 9 1/4, 344 pp. Suggested Price: $88.95 / £49.99

Catalog no. C6757, ISBN: 978-1-58488-675-4 2008, 6-1/8 x 9-1/4, 544 pp. Suggested Price: $73.95 / £34.99

TelAviv University, Israel

University of Alberta, Edmonton, Canada

Biophysics

Optical Tweezers

Methods and Applications

Textbook

Edited by

Introduction to Macromolecular Binding Equilibria Charles P. Woodbury

University of Illinois at Chicago, Chicago, Illinois, USA

This compact, graduate-level text focuses on a key area of biophysical chemistry. Introduction to Macromolecular Binding Equilibria first describes the features of binding sites for small molecules and then presents a discussion of the formulation of binding isotherms for simple mathematical models. The book addresses special problems in describing isotherms for linear polymers and examines the complications of binding cooperativity and thermodynamic linkage interactions among multiple ligands. It highlights important aspects of experimental designs, key aspects of ligand binding to planar arrays of sites, and methods for model-free analysis data used to reveal the binding isotherm. Catalog no. 52985, ISBN: 978-1-4200-5298-5 2008, 6-1/8 x 9-1/4, 272 pp. Suggested Price: $99.95 / £39.99

Miles J. Padgett

University of Glasgow, Scotland

Justin Molloy

MRC Institute for Medical Research, London, UK

David McGloin

University of Dundee, Scotland Series: Series in Optics and Optoelectronics

Using light to manipulate microscopic objects as small as a single atom, optical tweezers have revolutionized several areas of physics, especially biophysics, through the manipulation of cells, bacteria, and DNA. Bringing together key papers on optical tweezers and their applications, this collection covers the creation, design, use, and applications of optical tweezers. In this unique volume, the contributors discuss key developments in each area of physics that has been impacted by these tweezers and traps. The editors, well-known pioneers in the field, also provide an introduction and overview of each topic. Catalog no. C7412, ISBN: 978-1-4200-7412-3 January 2009, 7 x 10, 622 pp. Suggested Price: $149.95 / £83.00

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

Proteins

Energy, Heat and Signal Flow Edited by

Biocatalysis and Agricultural Biotechnology Edited by

Ching T. Hou

University of Nevada, Reno, USA

Jei-Fu Shaw

John Edward Straub

Boston University, Massachusetts, USA

National Chung Hsing University, Taichung, Taiwan

Proteins are the molecular machines of the cell, and computational modeling provides insight into how energy flow in proteins mediates protein function. The first book devoted to energy flow in proteins, this volume provides a broad overview of techniques used in the study of energy flow in biological molecules in general, in addition to its particular focus on proteins. It collects and connects a variety of computational approaches developed in distinct fields of research to reveal information central to our understanding of how proteins function, while also demonstrating methods that can be used to study energy and heat transport in condensed phase systems.

With contributions from 55 distinguished international experts comprising all sectors of academia, industry, and government research institutes, a virtual who’s who among biocatalysis scientists, this book brings together current advances and in-depth reviews of biocatalysis and agricultural biotechnology, emphasizing bio-based products and agricultural biotechnology. Divided into two sections, it covers the latest research on improvements of agronomic and microbial traits and bio-based industry products. It is an excellent reference for teachers, graduate students, and industrial scientists who conduct research in biosciences and biotechnology.

Catalog no. 87037, ISBN: 978-1-4200-8703-1 July 2009, 6-1/8 x 9-1/4, 424 pp. Suggested Price: $129.95 / £78.99

Catalog no. 77031, ISBN: 978-1-4200-7703-2 March 2009, 6-1/8 x 9-1/4, 448 pp. Suggested Price: $179.95 / £109.00

Advanced Signal Processing

Biocatalysis and Biotechnology for Functional Foods and Industrial Products

Theory and Implementation for Sonar, Radar, and NonInvasive Medical Diagnostic Systems, Second Edition

Edited by

Biophysics / Biotechnology

United States Department of Agriculture, Peoria, Illinois, USA

David M. Leitner

Ching T. Hou

United States Department of Agriculture, Peoria, Illinois, USA

Edited by

Stergios Stergiopoulos

University of Western Ontario, Cananda Series: Electrical Engineering & Applied Signal Processing Series

Jei-Fu Shaw

National Chung Hsing University, Taichung, Taiwan

Continuing in the best-selling tradition of the first edition, this book integrates topics of signal processing from sonar, radar, and medical system technologies by identifying their concept similarities. The second edition continues to gather the most pertinent information in advanced signal processing and provides substantial updates to the section on noninvasive medical diagnostic system applications, including intracranial ultrasound, an emerging technology that attempts to address noninvasive detection on brain injuries and stroke. The chapter entitled “Adapting Systems in Signal Processing” represents a coherent summary of Simon Haykin’s work in the relevant field.

The most current compendium available on functional foods and industrial products through bioprocesses, this book compiles selected papers from the International Symposium on Biocatalysis and Biotechnology held in October 2005. It covers the latest applications for enzyme catalysis, biotransformation, bioconversion, fermentation, genetic engineering, and product recovery. The first section focuses on functional food research including health food, nutritional supplements, and nutraceuticals. The second section is devoted to industrial applications such as biodegradable industrial lubricants, and the stabilization of living microbial biological control agents for insecticides.

Catalog no. 62387, ISBN: 978-1-4200-6238-0 March 2009, 7 x 10, 768 pp. Suggested Price: $159.95 / £97.00

Catalog no. AO9282, ISBN: 978-0-8493-9282-5 2007, 6-1/8 x 9-1/4, 563 pp. Suggested Price: $195.95 / £109.00

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For more information and a complete list

Biotechnology

A Comprehensive Training Guide for the Biotechnology Industry Syed Imtiaz Haider and Anika Ashtok

Biotechnology 84

Brewing

New Technologies Edited by

Julphar Gulf Pharm. Industries, United Arab Emirates

C.W. Bamforth

This comprehensive manual provides concise information covering the basic concepts, principles, and techniques used to ensure product quality, potency, efficacy, and safety in the biotechnology industry. Serving as a valuable tool for both new and existing biotechnology and biopharmaceutical manufacturers, this book also includes a CD-ROM with customizable features that offers hands-on training information. The text presents step-by-step guidance for optimizing research and development expenditures, avoiding marketing delays, gaining a competitive advantage, reducing product development failures, developing skilled manpower, and maintaining both local and international regulatory compliance.

Brewing continues to be one of the most competitive and innovative sectors in the food and drink industry. Brewing: New Technologies summarizes recent technological changes in brewing and their impact on product range and quality. The book begins with a review of the improvements in ingredients, including cereals, adjuncts, malt, and hops, and examines ways of optimizing the use of water. It discusses developments in technologies from fermentation and accelerated processing to filtration and stabilization processes, as well as packaging. It concludes with analyses of improvements in safety and quality control, including control systems responsible for chemical, microbiological, and sensory analysis.

Catalog no. 84488, ISBN: 978-1-4200-8448-1 March 2009, 7 x 10, 416 pp., Soft Cover Suggested Price: $99.95 / £60.99

Catalog no. WP9159, ISBN: 978-0-8493-9159-0 2007, 6 x 9, 484 pp. Suggested Price: $259.95 / £144.00

Biotechnology in Textile Processing Edited by

Georg M. Guebitz, Artur Cavaco-Paulo, and Ryszard Kozlowski Biotechnology in Textile Processing examines recent trends, techniques, and developments in the finishing and processing of natural fibers. The industry’s foremost experts present current research findings on textile biotechnology, bio-treatment, and waste water management, with an emphasis on developing environmentally friendly production technologies that use enzymatic processes. This vital book examines bio-technical methods that save chemicals and energy and improve the quality of the final product, using enzyme applications that act on both cellulose- and protein-based textiles. Catalog no. HW15744, ISBN: 978-1-56022-142-5 2007 Suggested Price: $52.95 / £29.99 Also Available in Soft Cover

University of California, Davis, California, USA

Development and Uses of Biofortified Agricultural Products Edited by

Gary S. Bañuelos

USDA, ARS, Fresno, California, USA

Zhi-Qing Lin

Southern Illinois University, Edwardsville, USA

Using a multidisciplinary approach, this volume provides new strategies and techniques for the production of biofortified agricultural products from different soils. Contributors from 12 countries explore the effects of environmental and biological factors on the accumulation and speciation of nutritionally important trace elements in agricultural products. They explore novel strategies regarding the functional foods and animal feed and other forms of biofortified agricultural products. The text also addresses alternative biosources and bioproducts produced from phytoremediation processes as well as the bioavailability and the effects of bioproduct compounds. Catalog no. 60058, ISBN: 978-1-4200-6005-8 January 2009, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $119.95 / £66.99

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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Synthesis, Testing, and Reconfiguration Techniques Krishnendu Chakrabarty

Duke University, Durham, North Carolina, USA

Fei Su

Functional Foods and Biotechnology Edited by

Kalidas Shetty, Gopinadhan Paliyath, Anthony L. Pometto, and Robert E. Levin

Intel Corporation, Folsom, California, USA

Series: Food Science and Technology, 165

This book focuses on the automated design of microfluidic-based biochips for large-scale bioassays and safety-critical applications. Highlighing a new generation of biochips that offer dynamic reconfigurability, system scalability, system integration, and defect tolerance, the authors present a system-level design automation framework that addresses key issues in the design, analysis, and testing of digital microfluidic biochips. Topics include: operation scheduling, test resource optimization, fault detection while running normal bioassays, and reconfiguration-based techniques designed to increase the yield and dependability of digital microfluidic biochips.

This volume focuses the information from the recently published Food Biotechnology to illuminate the role of biochemical processing in the improvement of foods. Applying scientific concepts, the text explores the design of functional food ingredients, the biomobilization of major nutrients, and the use of specific phenolic metabolites in disease prevention. Specialty topics include oxidation and disease, antibodies from eggs, phytochemicals as antimicrobials, and passive immune improvement with pro- and pre-biotics. The text provides key emerging techniques for improving food production, enhancing food safety, and increasing nutritional values and functional aspects of food.

Catalog no. 9009, ISBN: 978-0-8493-9009-8 2007, 6-1/8 x 9-1/4, 228 pp. Suggested Price: $144.95 / £79.99

Catalog no. 7527, ISBN: 978-0-8493-7527-9 2007, 7 x 10, 670 pp. Suggested Price: $164.95 / £92.00

Illustrated Dictionary of Biotechnology

Essentials of Biotechnology

Biotechnology

Digital Microfluidic Biochips

Himanshu Arora

R.C. Sobti and Suparna S. Pachouri

Ane Books, India

A comprehensive treatise on biotechnology, this volume starts with an overall review of early applications that scientists employed long before the field was defined. It then moves on to examine the emergence of current methods and specialized tools in the field, as well as cell culture and nucleic acid based technologies. It devotes individual chapters to biotechnology in the areas of health, agriculture, environment, aquaculture, and food. These are followed by chapters on the status of biotechnology in developing countries with special reference to India. It also discusses debated ethical considerations and explores ongoing issues regarding intellectual property rights and patents.

Illustrated Dictionary of Biotechnology includes a range of terms wide enough to satisfy the needs of any biologist, clinician, biochemist, lawyer, physician, scientist or scholar who requires easy reference to current usage of biotechnology. The concept of this dictionary originated from the need for a glossary for use in undergraduate teaching. It is written in a clear and lucid style that provides straightforward definitions and invaluable background information, so that the definitions can be understood by anyone with a minimum background of biological knowledge. Extensive cross-referencing expands individual definitions and enables a chosen theme to be followed through the book.

Catalog no. AB8284, ISBN: 978-1-4200-8284-5 January 2009, 7 x 9, 750 pp. Suggested Price: $119.95 / £66.99

Catalog no. N10040, ISBN: 978-1-4398-0173-4 January 2009, 6-1/8 x 9-1/4, 450 pp., Soft Cover Suggested Price: $59.95 / £33.99

Punjab University

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For more information and a complete list Macroporous Polymers

Production Properties and Biotechnological/Biomedical Applications Edited by

Bo Mattiasson

Lund University, Sweden

Ashok Kumar

Indian Institute of Technology, Kampur, India

Igor Galaev

Biotechnology

Lund University, Lund, Sweden

Macroporous polymers are rapidly becoming the material of choice for many tissue engineering, bioseparation, and bioprocessing applications. Presented in a systematic way, this book addresses the production, characterization, and application of macroporous polymers. The text considers traditional methods of production, including phase separation polymerication, leaching, foaming, and double emulstion, as well as newly merging methods such as cryogelation. With extensive references, the chapters also discuss in detail the various applications of macroporous gels for the separation of biomolecules and for the cultivation of mammalian cells in bioreactors and in tissue engineering. Catalog no. 84615, ISBN: 978-1-4200-8461-0 July 2009, 6-1/8 x 9-1/4, 450 pp. Suggested Price: $129.95 / £78.99

Textbook

Molecular Biotechnology

Principles and Practices Channarayappa

Vydehi Institute for Biotechnical Sciences, Genetics Department, Bangalore, India

Providing a strong base in this emerging and highly promising field, Molecular Biotechnology: Principles and Practice strikes a balance between two important aspects of the science: the theory of molecular biology and the experimental approach to the study of biological processes. The main feature of this book is that it covers a wide range of molecular techniques in biotechnology and is designed to be a student- and teacher-friendly textbook. Each technique is described conceptually, followed by a detailed experimental account of the steps involved. The book can also serve as reference for newcomers to the field of biotechnology. Catalog no. UN5157, ISBN: 978-1-4200-5157-5 2007, 7 x 10, 1228 pp. Suggested Price: $114.95 / £63.99

The Metabolic Pathway Engineering Handbook Two-Volume Set Christina D. Smolke

California Institute of Technology, Pasadena, USA

Christina Smolke, who recently developed a novel way to churn out large quantities of drugs from genetically modified brewer’s yeast, is regarded as one of the most brilliant new minds in biomedical engineering. In this handbook, she brings together pioneering scientists from dozens of disciplines to provide a complete record of accomplishment in metabolic pathway engineering. With a wealth of cutting edge research and analysis, this work also serves as an invaluable resource for those seeking to add their own contributions. Organized by topic, this 3000 page reference is available as two volumes that can be purchased individually or as a set.

Fundamentals The first volume provides an overview of metabolic pathway engineering with a look towards the future. It discusses cellular metabolism, including transport processes inside the cell and energy generating reactions, as well as rare metabolic conversions. This volume also explores balances and reaction models, the regulation of metabolic pathways, and genome scale and multiscale modeling tools. It also covers developing appropriate hosts for metabolic engineering including the use of Escherichia coli, yeast, bacillus subtilis, streptomyces, filamentous fungi, and mammalian cells using cell culture. Catalog no. K10164, ISBN: 978-1-4398-0296-0 July 2009, 7 x 10, 1000 pp. Suggested Price: $159.95 / £97.00

Tool and Applications The second volume delves into evolutionary tools as well as gene expression tools for metabolic pathway engineering. It covers applications of emerging technologies, including recent research genome-wide technologies, DNA and phenotypic microarrays, and proteomics tools for experimentally determining flux through pathways. This volume also looks at emerging applications for producing fine chemicals, drugs, and alternative fuels. Catalog no. 77651, ISBN: 978-1-4200-7765-0 July 2009, 7 x 10, 1500 pp. Suggested Price: $159.95 / £97.00

Order the Two Volume Set and Save! Catalog no. 3923, ISBN: 978-0-8493-3923-3 July 2009, 7 x 10, 2500 pp. Suggested Price: $199.95 / £121.00

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Plant Biotechnology in Ornamental Horticulture Edited by

Yi Li

University Of Connecticut, Storrs, Connecticut, USA

Smart Polymers

Applications in Biotechnology and Biomedicine, Second Edition Edited by

Yan Pei

Igor Galaev and Bo Mattiasson

Plant Biotechnology in Ornamental Horticulture presents an in-depth overview of the key scientific and technical advances, issues, and challenges in one of the fastest growing segments of the agriculture industry. This comprehensive book covers 19 different topics related to the use of transgenic plant technology to improve ornamental plants. Unique and focused in its approach, the book examines the metabolic engineering of flower color and scent, explores ways of improving cold, drought, and disease tolerance in horticultural and ornamental crops, and explores the economics of horticultural biotechnology.

Smart polymers have an extensive range of applications in the biotechnology and biomedical industries. Although polymers have always been considered passive participants, the second edition of Smart Polymers: Applications in Biotechnology and Biomedicine promotes a more active role for smart polymers within the process of bioseparation than previously envisioned. This book addresses the major developments in the field that have taken place since the previous edition. With contributions from leading researchers as well as extensive end-of-chapter references, this volume offers a comprehensive overview of the current state-of-the-art in the field and the potential for future developments.

Lund University, Sweden

Catalog no. HW14894, ISBN: 978-1-56022-150-0 2007 Suggested Price: $93.95 / £51.99 Also Available in Soft Cover

Catalog no. 9161, ISBN: 978-0-8493-9161-3 2008, 6-1/8 x 9-1/4, 496 pp. Suggested Price: $134.95 / £74.99

Smart Biosensor Technology

Therapeutic Peptides and Proteins

Edited by

George K. Knopf and Amarjeet S. Bassi

The University of Western Ontario, London, Canada

Biotechnology

Willington, Connecticut, USA

Formulation, Processing, and Delivery Systems, Second Edition Ajay K. Banga

Series: Optical Science and Engineering, 118

Mercer University, Macon, Georgia, USA

This book examines the design, applications, and future directions of smart biosensor technologies. Following an introduction to fundamental characteristics and functions, it explores the role materials play in developing smart biosensors. Next, the book devotes an entire section to bioelectronics, focusing on a biophotonic material called bacteriorhodopsin and its application to photoelectric biosensing, chemical sensing, and color imaging. It also examines the design and fabrication of new bioelectronic sensing arrays on flexible substrates and explores a variety of smart biosensor applications in detecting food pathogens, monitoring toxicity, and detecting allergens and viruses.

Reflecting the explosive growth of biotechnology medications, this edition of Therapeutic Peptides and Proteins contains more than 50 percent new material. It provides hard-to-find information addressing therapeutic drugs made from proteins and protein-based vaccines. Embracing an industrial perspective, it examines the origin of recombinant proteins, explores structural and analytical aspects, discusses protein and peptide stability, and offers a new chapter on recombinant protein subunit vaccines and delivery systems. By presenting complex information in a simple style with minimal overlap, the book utilizes extensive cross-referencing to enhance its value as a resource.

Catalog no. DK6041, ISBN: 978-0-8493-3759-8 2007, 7 x 10, 664 pp. Suggested Price: $154.95 / £86.00

Catalog no. 1630, ISBN: 978-0-8493-1630-2 2006, 6-1/8 x 9-1/4, 376 pp. Suggested Price: $209.95 / £117.00

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For more information and a complete list Advances in Chromatography Hebrew University of Jerusalem, Israel

A Concise Guide to Intraoperative Monitoring

Nelu Grinberg

George Zouridakis

Edited by

Eli Grushka

Methods & Instrumentation

Boehringer-Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA Series: Advances in Chromatography

Volume 47 For more than four decades, scientists and researchers have relied upon the Advances in Chromatography series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. Covering the state-of-the-art in separation science, this volume continues to present timely and cutting-edge reviews in the fields of bio, analytical, organic, polymer, and pharmaceutical chemistry. Compiled from leading researchers around the world, new chapters cover countercurrent chromatography and large-scale genotyping as well as cyclic voltammetry, a powerful tool for determining the electrochemical characteristics of organic compounds. Catalog no. 60368, ISBN: 978-1-4200-6036-2 February 2009, 6-1/8 x 9-1/4, 470 pp. Suggested Price: $189.95 / £115.00

University of Houston, Texas, USA

Andrew C. Papanicolaou

University of Texas, Houston, USA

The use of electrophysiological recordings to assess the functional integrity of the nervous system during surgery is gradually becoming part of standard medical practice. This book provides a general but comprehensive introduction to intraoperative monitoring. It includes pictures and drawings that show the exact placement of stimulation and recording electrodes, and contains tables that show exact stimulation and recording parameters and the detailed effects of anesthetic agents on neurophysiological signals. It offers examples of normal recordings and presents discussion of problems that can occur during surgery along with the corresponding abnormal recordings. Catalog no. 0886, ISBN: 978-0-8493-0886-4 2001, 6-1/8 x 9-1/4, 216 pp. Suggested Price: $114.95 / £63.99

Volume 46

This volume covers advances in twodimensional gas chromatography, reversed phase liquid chromatography/shape selectivity, and supercritical fluid chromatography. It highlights enantioselective separations with emphasis on chiral recognition mechanisms, screening approaches, and separation speed. It also explores hyphenated techniques and enhanced fluidity chromatography. Catalog no. 60252 ISBN: 978-1-4200-6025-6 2008, 6-1/8 x 9-1/4, 488 pp. Suggested Price: $189.95 / £100.00

Volume 45 Volume 45 discusses the use of alternative solvents and reagents, minimum requirements for utilizing readily available instrumentation for new applications, combinatorial library design strategies and high-throughput purification methods for obtaining higher quality leads, and new chromatographic data on organic endocrine disrupters. Catalog no. DK4478 ISBN: 978-1-57444-735-4 2007, 6-1/8 x 9-1/4, 285 pp. Suggested Price: $189.95 / £100.00

FLIM Microscopy in Biology and Medicine Edited by

Ammasi Periasamy

University of Virginia, Charlottesville, Virginia, USA

Robert M. Clegg

University of Illinois, Urbana, USA

Suitable for a variety of applications in biology and biomedical research, fluorescence lifetime imaging (FLIM) is a powerful new tool for advanced quantitative analysis. Its high contrast and sensitivity allow for the detection of signals at the single molecule level. After an overview of basic principles of fluorescence, microscopy, and FLIM, this book discusses probes, dynamic and video rate FLIM imaging, laser scanning confocal FLIM, spectral lifetime imaging, nonlinear curve-fitting methods, global FLIM data analysis, and new approaches in data analysis. Widely recognized as pioneers in the field, the editors offer a summary chapter on current FLIM applications. Catalog no. C7890, ISBN: 978-1-4200-7890-9 June 2009, 7 x 10, 352 pp. Suggested Price: $99.95 / £60.99

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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Fluorescence Detection Techniques for Biomedical Research

Handbook of Food Analysis Instruments

Iain D. Johnson

Semih Otles

Fluorescence is the most versatile detection technique currently available for biomedical research. No other technique can be used to address as many different types of samples using as many different instrumentation platforms. This volume describes the technical basis for this versatility and provides a complete look at the wide span of resulting applications. The first part of the text examines basic photophysics of the fluorescence process, explains the properties of fluorescent molecules, and presents instrumentation platforms. Organized by classes of biological molecules, the second part of the text focuses on applications.

The presence and interactions of various compounds in foods during storage and processing impact all aspects of quality. Therefore, applying proper methods for the analysis of foods is a critical endeavor. During the past century, analytical methods have evolved considerably to include the use of increasingly sophisticated instruments. The Handbook of Food Analysis Instruments focuses on the origin, concept, and use of these instruments. Each chapter presents a specific type of instrument, nuclear magnetic resonance spectroscopy, microwave-assisted processes, and more. The operating principles, definitions, theory, and applications to food analysis are examined for every instrument covered in the text.

Invitrogen Corporation, Eugene, Oregon, USA

Catalog no. 7478, ISBN: 978-0-8493-7478-4 May 2009, 7 x 10, 352 pp. Suggested Price: $149.95 / £89.00

Handbook of CryoPreparation Methods for Electron Microscopy

Edited by Ege University, Izmir, Turkey

Catalog no. 45660, ISBN: 978-1-4200-4566-6 January 2009, 7 x 10, 544 pp. Suggested Price: $169.95 / £94.00

Handbook of NearInfrared Analysis

Edited by

Third Edition

Annie Cavalier

Edited by

University de Rennes, France

Donald A. Burns

Daniele Spehner

NIR Resources, Los Alamos, New Mexico, USA

University of Strasbourg, Illkirch, France

Bruno M. Humbel

Methods & Instrumentation

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

Emil W. Ciurczak

Utrecht University, The Netherlands

Cadrai Technologies, Goldens Bridge, New York, USA

Series: Methods in Visualization

Series: Practical Spectroscopy

The last two decades have seen exponential growth in cryoelectron microscopy, resulting in exciting advances and a better understanding of the ultrastructure of living and inert matter. Using a step-by-step format, this handbook presents the most sophisticated methods used in research laboratories. It describes the principles of cryo-fixation, cryo-ultramicrotomy, embedding at low temperatures, and freeze-fracture. It also explores applications such as electron crystallography, 2D/3D structure analysis, cryo-electron tomography, and techniques for protein localization. Each chapter covers a specific method, including detailed protocols, summary tables, and illustrations to clarify the techniques.

Presenting nearly 50 percent new and revised material, this edition combines concise theoretical foundations with the latest advances in instrumentation, computerization, calibration, and methods in NIR spectroscopy. Drawing on the experience of more than 60 experts in the field, it underscores accurate as well as time- and cost-effective current trends in sample preparation, calibration transfer, process control, data analysis, and commercial NIR instrumentation. New chapters highlight novel applications in pharmaceuticals, polymers, plastics, petrochemicals, textiles, foods and beverages, baked products, agricultural products, biomedicine, neutraceuticals, and counterfeit detection.

Catalog no. 7227, ISBN: 978-0-8493-7227-8 January 2009, 7 x 10, 704 pp. Suggested Price: $179.95 / £99.00

Catalog no. 7393, ISBN: 978-0-8493-7393-0 2008, 7 x 10, 826 pp. Suggested Price: $229.95 / £127.00

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For more information and a complete list Hyphenated and Alternative Methods of Detection in Chromatography Edited by

R. Andrew Shalliker

Methods & Instrumentation 90

University of Western Sydney, Center for Biostructural & Biomolecular Research, Australia

Textbook

An Introduction to Microscopy Suzanne Bell and Keith Morris

Series: Chromatographic Science Series

West Virginia University, Morgantown, Virginia, USA

Widely employed for separating and detecting chemicals in solution, separation techniques are most often applied in tandem, subsequently referred to as hyphenated methods. Hyphenated and Alternative Methods of Detection in Chromatography details the development and application of mass spectral detection techniques coupled with gas phase and liquid phase chromatographies. The book details the advantages and disadvantages of various separation techniques and addresses methods for cutting-edge applications such as proteomics research. This book provides a detailed reference for experienced readers as well as for those who are new to the field of separation and analysis.

An Introduction to Microscopy provides a foundation in the basics of light and polarizing microscopy. Highlighting key terms and background material, the book details topics ranging from basic theoretical knowledge to advanced subjects, such as electron and confocal microscopy, as well as fluorescence. The authors provide an accompanying CD-ROM, which features color images, videos, and additional supporting material. An instructor’s guide for qualifying professors includes solutions to homework and laboratory exercises intended for undergraduate and graduate students. This volume focuses on forensic science but also explores the various disciplines that benefit from microscopy applications

Catalog no. 9077, ISBN: 978-0-8493-9077-7 May 2009, 6 x 9, 330 pp. Suggested Price: $169.95 / £103.00

Catalog no. 8450X, ISBN: 978-1-4200-8450-4 July 2009, 6-1/8 x 9-1/4, 256 pp. Suggested Price: $69.95 / £42.99

Immunoassay and Other Bioanalytical Techniques

Liquid ChromatographyMass Spectrometry Third Edition

Wilfried M.A. Niessen

Edited by

Jeanette M. Van Emon

US Environmental Protection Agency, Las Vegas, Nevada, USA

Using an interdisciplinary approach, Immunoassay and Other Bioanalytical Techniques describes the strength and the versatility of immunochemical and related bioanalytical methods for a wide range of environmental and biological measurement applications. This book explores the wide base of immunoassay methods and discusses the evolution of the technology. It presents both standard and innovative applications of immunochemical and related methods as well as quality assurance guidelines. It also offers insight into recently developed products and procedures. With the field expanding rapidly, this text presents updates on breakthrough research, including the impact of nanotechnology. Catalog no. DK9421, ISBN: 978-0-8493-3942-4 2007, 7 x 10, 536 pp. Suggested Price: $149.95 / £85.00

Hyphen MassSpec Consultancy, Leiden, The Netherlands Series: Chromatographic Science Series

Featuring new chapters and extensive revisions throughout, this classic work explains how to use LC–MS and interpret data for various disciplines. This edition places a stronger emphasis on applications, dedicating more than two-thirds of the text to examining new developments of LC–MS in emerging application areas, including environmental, food-safety, and clinical analysis as well as proteomics, pharmaceutical drug discovery and natural products research. Supported by most relevant literature available, each chapter examines how the strategies, technologies, and recent advances in LC–MS continue to shape many disciplines. Catalog no. DK2272, ISBN: 978-0-8247-4082-5 2007, 6 x 9, 632 pp. Suggested Price: $185.95 / £103.00

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Medical Instrumentation

Accessibility and Usability Considerations

Textbook

Measurement and Detection of Radiation

Edited by

Nicholas Tsoulfanidis

University of Nevada, Reno, USA

Human Spectrum Design, LLC, Santa Rosa, California, USA

Assuming a basic knowledge of calculus, differential equations and some atomic physics, this classic bestseller enables students to select the proper detector, analyze the results of counting experiments, and perform radiation measurements following proper health physics procedures. Examples and problems in each chapter ensure that students understand the concepts presented. The book covers longrange alpha detector LRAD, pure geranium detectors, magnetic and electrostatic spectrometers, position-sensitive detectors, the LSL-M2 unfolding code, compensated ion chambers, self-powered neutron detectors, new protection guides, and exposure limits. A solutions manual is available for qualifying instructors.

This forward-looking resource focuses on how usability and accessibility pose problems for designers and users and explores how to overcome these limitations. Divided into five broad sections, it begins by addressing the nature and extent of the problem by identifying access barriers, human factors, and policy issues focused on the existing infrastructure. The subsequent sections explore tools for usability and accessibility analysis, considerations for design guidelines, and emerging trends and future technologies. Finally, the book presents the results of the recent Workshop on Accessible Interfaces for Medical Instrumentation that outlines key challenges, knowledge gaps, and recommendations.

Catalog no. GS857, ISBN: 978-1-56032-317-4 1995, 6 x 9, 636 pp. Suggested Price: $175.95 / £98.00

Catalog no. 651X, ISBN: 978-0-8493-7165-3 2007, 7 x 10, 474 pp. Suggested Price: $144.95 / £79.99

Jack M. Winters

Molly Follette Story

The Measurement, Instrumentation and Sensors Handbook Edited by

NMR Primer

John G. Webster

Edited by

University of Wisconsin, Madison, USA

Supriyo Ghosh

Series: Electrical Engineering Handbook, 14

Bruker Optics, Woodlands, Texas, USA

Edited by one of the most renowned instrumentation experts in the world, this best-selling handbook contains nearly 150 contributions covering all aspects of the design and implementation of instrumentation. It describes the use of instruments and techniques for performing practical measurements in engineering, physics, chemistry, and the life sciences. Organized according to measurement problem, each section addresses the different ways of making a measurement for a given variable. Each chapter presents basic information, a detailed mathematical treatment, and advanced applications, evaluative opinions, and areas for future study.

Nuclear magnetic resonance technology uses portable instrumentation to quantify the physicochemical properties of materials. Focusing on practical applications, this book presents a clear and concise introduction to NMR fundamentals, with a particular emphasis on time-domain NMR. The text is suitable for those without a technical background and avoids complex math and physics; instead, the chapters give brief details of the math and physics involved as needed. Original scientific diagrams are artfully employed to aid understanding. The book also discusses various applications of NMR, explains advanced data processing techniques, and includes a comprehensive list of references.

Catalog no. 8347, ISBN: 978-0-8493-8347-2 1999, 7 x 10, 2608 pp. Suggested Price: $209.95 / £117.00

Methods & Instrumentation

Marquette University, Milwaukee, Wisconsin, USA

Catalog no. K10064, ISBN: 978-1-4398-0079-9 July 2009, 6-1/8 x 9-1/4, 350 pp. Suggested Price: $89.95 / £54.99

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Methods & Instrumentation / Nanobiotechnology 92

Spectral Techniques in Proteomics

Chromosome Nanoscience and Technology Edited by

Kiichi Fukui

Edited by

Osaka University, Japan

Daniel S. Sem

Marquette University, Milwaukee, Wisconsin, USA

Tatsuo Ushiki

Providing insight into future directions in the application of spectral techniques in proteomics, this book presents a cutting edge view of the techniques used to analyze proteomes. Tailored for those new to proteomics, it is also useful to the experienced researcher wishing to expand his or her toolbox. Spectral Techniques in Proteomics begins with an overview of structural proteomics and chemical proteomics, followed by an in-depth presentation of widely used methods like ESI, MALDI, SELDI, ICAT, tandem MS, and shotgun proteomics. The book also presents spectroscopic tools like SPR, EPR, NIR fluorescence, x-ray crystallography and NMR, providing a uniquely broad perspective of the field.

Reviewing new trends and techniques for future chromosome research, this volume draws upon scientists from many disciplines to introduce various nano devices and applications that have been developed for handling the smallest biological materials, especially chromosomes. It details the visualization of chromosomes at nano and micro levels, including the most advanced applications ever employed for scanning probe microscopy; discusses the development of a sustainable chromosome imaging database; examines isolation, comparative proteome analyses, and structural/functional analyses including a new 3-dimensional model; and describes a new antibody production method for chromosomal proteins.

Catalog no. DK3714, ISBN: 978-1-57444-580-0 2007, 8-1/2 x 11, 464 pp. Suggested Price: $139.95 / £76.99

Catalog no. 44915, ISBN: 978-1-4200-4491-1 2008, 6-1/8 x 9-1/4, 288 pp. Suggested Price: $144.95 / £79.99

Bionanotechnology

Niigata University, Japan

Global Prospects

DNA Nanotechnology

Edited by

Satyam Priyadarshy

David E. Reisner

RKR Group, Inc., Herndon, Virginia, USA

The Nano Group, Inc., Farmington, Connecticut, USA

Latha Shankar

As the impact of nanotechnology continues to grow, it is important for the modern biomedical engineer to have a deeply rooted understanding of bionanotechnologies. Featuring chapters drawn from the third edition of the best-selling Handbook of Biomedical Engineering as well as new contributions not found in the Handbook, Bionanotechnology takes a broad survey of the current research and activities that are shaping this burgeoning field. Covering both technical and non-technical areas, the book discusses the role of nanotechnology in novel medical devices, bioanalytical technologies, and nano-biomaterials, as well as intellectual property issues that are unique to nanotechnologies.

DNA is a versatile molecule, ideal for building complex structures at the nanometer scale, yet until now scientists have lacked a cohesive reference that details nanotechnology applications in which DNA plays a key role. A tremendous aid to researchers, this work describes current applications across many fields including robotics, lithography, computation, electronics, and fabrication. Whether you are building biomedical scaffolds, designing molecular motors, or producing nanowires, sensors, solar cells or new fuels, this work will inform you as to what has been accomplished, while expanding understanding of what is possible.

Catalog no. 7528, ISBN: 978-0-8493-7528-6 January 2009, 7 x 10, 368 pp. Suggested Price: $89.95 / £49.99

Herndon, Virginia, USA

Catalog no. 86332, ISBN: 978-1-4200-8633-1 July 2009, 6-1/8 x 9-1/4, 464 pp. Suggested Price: $149.95 / £89.00

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Nanotechnology 2008 Three-Volume Set Edited by

Nano Science & Technology Institute

Fundamentals of Nanotechnology Gabor L. Hornyak, John J. Moore, Harry F. Tibbals, and Joydeep Dutta Nanotechnology is no longer a subdiscipline of chemistry, engineering, or any other field. It represents the convergence of many fields, and therefore demands a new paradigm for teaching. This textbook is for the next generation of nanotechnologists. It surveys the field’s broad landscape, exploring the physical basics such as nanorheology, nanofluidics, and nanomechanics as well as industrial concerns such as manufacturing, reliability, and safety. The authors explore the vast range of nanomaterials and systematically outline devices and applications in various industrial sectors. This color text is an ideal companion to Introduction to Nanoscience by the same group of esteemed authors. Catalog no. 48031, ISBN: 978-1-4200-4803-2 January 2009, 7 x 10, 786 pp. Suggested Price: $89.95 / £49.99

Nano-Biophotonics Applications in Advanced Cellular and Molecular Imaging Edited by

The NSTI Nanotech conference offers the most prestigious forum in the world for leading nano scientists. These volumes contain papers from the 2008 conference, making them the most authoritative and comprehensive compendium available across all of disciplines of nanotechnology. Including the latest information on industrial development, investments, and ventures, each volume explores cutting-edge research and applications.

Order the Three Volume Set and Save! Catalog no. 85077, ISBN: 978-1-4200-8507-5 January 2009, 8-1/2 x 11, 2749 pp. Suggested Price: $550.00 / £306.00

Also available on CD-ROM Catalog no. 85115, ISBN: 978-1-4200-8511-2 January 2009, 8-1/2 x 11, 2800 pp. Suggested Price: $550.00 / £306.00

Materials, Fabrication, Particles, and Characterization Volume I covers structures, materials, surfaces, fabrication, nanolithography, and characterization, along with various novel applications. This volume also examines worldwide research initiatives and education policies.

Stephen M. Lane

Catalog no. 85034, ISBN: 978-1-4200-8503-7 January 2009, 8-1/2 x 11, 1120 pp., Soft Cover Suggested Price: $199.95 / £111.00

Thomas Huser

Life Sciences, Medicine, and Bio Materials

Lawrence Livermore National Laboratories, California, USA University of California, Davis, USA Series: Biophotonic Science and Engineering

Part of the new Biophotonic Science and Engineering series, NanoBiophotonics Applications in Advanced Cellular and Molecular Imaging provides up-to-date coverage of biophotonics techniques ranging from probes for cellular and molecular imaging to imaging at the single-cell and single molecule-level. Extensively illustrated, this book features contributions from leading experts from various national research institutions. Additional topics include plasmonic probes, quantum dots, fluorescent proteins, multiphoton microscopy, ultra-sensitive spinning-disk confocal microscopy, soft X-ray imaging of individual cells and organisms, nonlinear imaging, and stimulated emission depletion microscopy. Catalog no. 7275, ISBN: 978-0-8493-7275-9 July 2009, 6-1/8 x 9-1/4, 400 pp. Suggested Price: $139.95 / £85.00

Nanobiotechnology

Cambridge, Massachusetts, USA

Textbook

Volume II explores various aspects of cancer treatment, biomarkers, nanoparticles, drug delivery systems, nanobiotechnology, nanomedicine, nanoneurology, sensors, and soft nanotechnology. Catalog no. 85042, ISBN: 978-1-4200-8504-4 January 2009, 8-1/2 x 11, 810 pp., Soft Cover Suggested Price: $199.95 / £111.00

Microsystems, Photonics, Sensors, Fluidics, Modeling and Simulation Volume III discusses photonics, nanowires, lab-on-a-chip, nanofluidics, MEMS, and NEMS. In addition, this volume explores the modeling and simulation of microsystems, computational nanoscience, and compact modeling. Catalog no. 85050, ISBN: 978-1-4200-8505-1 January 2009, 8-1/2 x 11, 946 pp., Soft Cover Suggested Price: $199.95 / £111.00

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Nanobiotechnology / Tissue Engineering 94

Nanotechnology in Biology and Medicine

3D Fibrous Assemblies

Edited by

Properties, Applications and Modelling of Three-Dimensional Textile Structures

Tuan Vo-Dinh

Jinlian Hu

The latest generation of nanodevices enables scientists to more accurately detect, analyze, and manipulate nanostructures at the molecular level. With emphasis on the application and design of nanomaterials, devices, and sensors, Nanotechnology in Biology and Medicine carefully details current methods, protocols, and instrumentation for biomedical applications including stem cell research, gene diagnostics, targeted drug delivery, and tissue engineering. Pioneers in the field offer a cohesive compilation of data, practical tool kits, references, and experimental insight on relevant topics, including self-assembly, bio-inspired materials, and biomanufacturing.

Written by a distinguished author, 3D Fibrous Assemblies summarizes key developments and their applications in the textile industry. The book begins with an introduction to the concepts and types of 3D fibrous assemblies. The author then discusses how 3D fabrics can be applied in textiles products. These range from composites and protective clothing to medical textiles. The remainder of the text reviews the two main 3D fabrics; multiaxial warp knitted fabrics and multi-layer woven fabrics, exploring themes such as structure, manufacture, properties, and modeling for both fabrics. This highly comprehensive volume is destined to be a pioneering guide for a broad spectrum of readers.

Catalog no. 2949, ISBN: 978-0-8493-2949-4 2007, 7 x 10, 792 pp. Suggested Price: $154.95 / £86.00

Catalog no. WP7986, ISBN: 978-1-4200-7986-9 January 2009, 6-1/8 x 9-1/4, 256 pp. Suggested Price: $219.95 / £115.00

Methods, Devices, and Applications

Duke University, Durham, North Carolina, USA

Hong Kong Polytechnic University, China

Biomaterials and Tissue Engineering in Urology Nanotechnology and Human Health

Edited by

Ineke Malsch

A. Atala

Addressing medium- and long-term expectations for human health, this book reviews current scientific and technical developments in nanotechnology for biomedical, agrofood, and environmental applications. This collection of perspectives on the ethical, legal, and societal implications of bionanotechnology provides unique insight into contemporary technological developments. Readers with a technical background will benefit from the overview of the state-of-the-art research in their field, while those from social sciences will appreciate the discussion of the realistic prospects of nanotechnology. The text also includes a glossary as well as extensive end-of-chapter references.

An invaluable resource for clinicians as well as for researchers in materials and biomedical devices, this text summarizes recent research on the use of biomaterials and tissue engineering in the treatment of urological disorders. The first section reviews the fundamentals including biofilms and encrustation formation. The next part discusses recent advances in biomaterials and the design of urological devices such as metal ureteral stents, self-lubricating catheter materials, and penile implants. The final section addresses urological tissue engineering, covering artificial and natural biomaterials, nanotechnology, and placental stem cells used for the regeneration of urological tissue and organs.

Catalog no. 8144, ISBN: 978-0-8493-8144-7 July 2009, 6-1/8 x 9-1/4, 300 pp. Suggested Price: $119.95 / £72.99

Catalog no. N10041, ISBN: 978-1-4398-0177-2 May 2009, 6 x 9, 500 pp. Suggested Price: $289.95 / £153.00

Malsch Techno Valuation, Utrecht, The Netherlands

J. Denstedt

University of Western Ontario, Canada Wake Forest University, Winston-Salem, North Carolina, USA

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

Nanotechnology and Tissue Engineering The Scaffold

Tissue Engineering John P. Fisher

Edited by

University of Maryland, College Park, USA

Cato T. Laurencin

Antonios G. Mikos

Lakshmi S. Nair

Joseph D. Bronzino

With chapters written by world famous researchers involved with various facets of nanostructured scaffolds, this is the first resource that brings together current research and background information on a complete range of engineering processes that have led to the development of a number of highly useful tissues. It details the fundamental and advanced aspects of nanofabrication and includes an examination of cellular interactions at the nanoscale level. This highly comprehensive resource also discusses clinical implications and applications, making it a work of importance for clinicians, as well as an essential reference for engineers and other scientists seeking to further advance the field.

The ability to engineer biocompatible tissue is the hallmark of modern biomedical engineering, integrating all aspects of every sub-discipline in the field. Featuring chapters drawn from the third edition of the best-selling Handbook of Biomedical Engineering as well as new contributions not found in the Handbook, Tissue Engineering surveys the latest advances in this relatively young area. The book discusses the fundamental concepts of tissue engineering, enabling technologies, and tissue engineering applications. It examines strategies that incorporate scaffolds, nanocomposites, bioreactors, drug delivery systems, and gene therapy techniques that are being applied in regenerative medicine.

Catalog no. 51822, ISBN: 978-1-4200-5182-7 2008, 7 x 10, 384 pp. Suggested Price: $149.95 / £83.00

Catalog no. 9026, ISBN: 978-0-8493-9026-5 2007, 7 x 10, 600 pp. Suggested Price: $93.95 / £51.99

University of Connecticut, Farmington, USA

Scaffolding in Tissue Engineering Edited by

Peter X. Ma

University of Michigan, Ann Arbor, USA

Jennifer Elisseeff

Johns Hopkins University, Baltimore, Maryland, USA

Reflecting the growing interest in scaffolding design and increasing research programs dedicated to regenerative medicine, Scaffolding in Tissue Engineering reviews the general principles of tissue engineering and examines methods and applications for a broad range of tissue engineering scaffolds. It presents an in-depth exploration of traditional and novel materials, fabrication technologies, including three-dimensional scaffold design, structural and functional scaffold modification, and various tissue engineering applications. This book offers insight into new trends and directions for scaffold development and for an ever-expanding range of tissue engineering applications. Catalog no. DK3367, ISBN: 978-1-57444-521-3 2006, 7 x 10, 656 pp. Suggested Price: $195.95 / £109.00

Rice University, Houston, Texas, USA Trinity College, Hartford, Connecticut, USA

Tissue Engineering and Artificial Organs

Tissue Engineering

University of Virginia, Charlottesville, USA

Edited by

Joseph D. Bronzino

Trinity College, Hartford, Connecticut, USA

The Biomedical Engineering Handbook enters its third edition as a set of three carefully focused and conveniently organized books. Reviewing applications at the leading edge of modern biomedical engineering, Tissue Engineering and Artificial Organs explores transport phenomena, biomimetics systems, biotechnology, prostheses, artificial organs, and ethical issues. The book features approximately 90% new material in the tissue engineering section, integrates coverage of life sciences with a new section on molecular biology, and includes a new section on bionanotechnology. Prominent leaders from around the world share their expertise in their respective fields with many new and updated chapters. For information on the complete handbook, see page 68

Catalog no. 2123, ISBN: 978-0-8493-2123-8 2006, 7 x 10, 1304 pp. Suggested Price: $134.95 / £74.99

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Tissue Engineering / Biopharmaceuticals 96

Tissue Engineering Using Ceramics and Polymers

Cell Culture Technology for Pharmaceutical and Cell-Based Therapies Edited by

Sadettin Ozturk

Edited by

Aldo R. Boccaccini

Centocor Inc., Nottingham, Pennsylvania, USA

Julie E. Gough

University of Minnesota, Minneapolis, USA

The University of Manchester, UK

Series: Biotechnology and Bioprocessing, 30

Bringing together an international team of highly respected contributors, this book reviews the latest research and advances in tissue engineering and explores how they can be used to develop treatments for disease states. An innovative and up-to-date reference, it begins with a discussion of general issues and then moves on to review characterization. Building on this foundation, later chapters analyze bone regeneration and specific types of tissue engineering and repair such as cardiac, intervertebral disc, skin, kidney and bladder tissue. The book concludes with coverage of themes such as nerve bioengineering and the micromechanics of hydroxyapatitebased biomaterials and tissue scaffolds.

This reference presents a comprehensive overview of the state-of-theart in cell culture technology. The book describes manipulations and the genetic engineering of cells for the production of biotechnology products, tissue engineering, and cell-based therapies. Each expertly written chapter covers research, principles, and equipment currently affecting advances in the discovery of genes, host cell selection, cloning and gene amplification, bioreactor design, protein purification, optimization and scale-up, product quality, and facility design. This volume showcases the importance of genomic and cellbased technologies in the pharmaceutical industry.

Imperial College London, UK

Catalog no. WP4454, ISBN: 978-1-4200-4454-6 2008, 6 x 9, 604 pp. Suggested Price: $339.95 / £189.00

Biocatalysis in the Pharmaceutical and Biotechnology Industries Edited by

Ramesh N. Patel

Wei-Shou Hu

Catalog no. DK1481, ISBN: 978-0-8247-5334-4 2006, 7 x 10, 776 pp. Suggested Price: $195.95 / £109.00

Chemicals from Microalgae

Bristol Myers Squibb Pharmaceutical Institute, New Brunswick, New Jersey, USA

Zvi Cohen

This book illustrates the practical advantages and methods for using biocatalysts to produce enantiospecific pharmaceuticals and fine chemicals. It offers detailed mechanisms for enzyme-catalyzed modification reactions, analyzing syntheses for over 60 brand-name pharmaceuticals. It also describes instrumentation, solvent selection, and techniques for enzyme immobilization and highlights recent advances such as the use of microbial cells and isolated biocatalysts, gene shuffling, and generating novel molecules for high-throughput screening. The book contains more than 4000 references and 1000 tables, equations, drawings, and color micrographs.

The production of chemicals from microalgae is becoming a significant area of biological research. Chemicals from Microalgae covers a number of various topics that relate to the use of microalgae as a source of chemicals. This authoritative reference discusses the occurrence and physiological role of these chemicals and concentrates on the methods aimed at enhancing their content. It also reviews large-scale algal biomass production and examines down-stream processing. A highly comprehensive resource, this timeless volume provides a thorough review of the major algal chemicals of interest, namely pigments and lipids.

Catalog no. DK6020, ISBN: 978-0-8493-3732-1 2007, 7 x 10, 893 pp. Suggested Price: $175.95 / £98.00

Catalog no. TF2006, ISBN: 978-0-7484-0515-2 1999, 6-1/8 x 9-1/4, 419 pp. Suggested Price: $229.95 / £128.00

Ben-Gurion University of the Negev, Israel

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Pharmaceutical Biotechnology

Fundamentals and Applications, Third Edition

Emerging Protein Biotherapeutics

Edited by

Daan J.A. Crommelin

Utrecht University, The Netherlands

Edited by

Robert D. Sindelar

Iqbal S. Grewal

Bernd Meibohm

Vice President, Preclinical Therapeutics, Seattle Genetics, Bothell, Washington, USA

Given the speed at which antibody therapy is becoming readily accepted, a comprehensive industry guide is sorely needed. Written by leading international authorities, this book maintains an overall emphasis on various therapeutic approaches and applications and provides critical discussions on the most significant areas of research in biologics. It also addresses pre-clinical safety testing of biologics and focuses on the applications of protein biologics in autoimmunity and inflammation, hematological malignancies, and solid tumors. The thorough nature of this volume makes it an unrivaled reference source beneficial to those in both academia and biotechnology industries. Catalog no. 63200, ISBN: 978-1-4200-6320-2 June 2009, 6-1/8 x 9-1/4, 392 pp. Suggested Price: $159.95 / £97.00

University of Tennessee Health Science Center, Memphis, USA

A completely revised text that reflects emergent trends and cutting-edge advances in pharmaceutical biotechnology, this third edition provides a well-balanced framework for understanding every major aspect of pharmaceutical biotechnology, including drug development, production, dosage forms, administration, and therapeutic developments. New chapters cover evolving areas regarding biopharmaceuticals, including oligonucleotides, siRNA and various monoclonal antibodies, immunogenicity, gene therapy, and the regulatory issues factoring into the biopharmaceutical approval process. This text sets the standard for biopharmaceutical education in the 21st century.

Biopharmaceuticals

University of British Columbia, Vancouver, Canada

Catalog no. H6752, ISBN: 978-1-4200-6752-1 2008, 8-1/2 x 11, 496 pp. Suggested Price: $249.95 / £125.00 Also Available in Soft Cover

Handbook of Pharmaceutical Controlled Release Technology Edited by

Process Scale Bioseparations for the Biopharmaceutical Industry Edited by

Abhinav A. Shukla

Bristol-Myers Squibb, East Syracuse, New York, USA

Mark R. Etzel

University of Wisconsin-Madison, USA

Donald L. Wise

Shishir Gadam

Reviewing the design, fabrication, methodology, administration, and classifications of various drug delivery systems, the bestselling Handbook of Pharmaceutical Controlled Release Technology provides exhaustive coverage on a huge range of systems and devices. It fully examines the cost, comfort, disease control, side effects, and patient compliance involved with the oral, transdermal, parenteral, and implantable delivery of drugs. Among a wealth of topics, it discusses controlled release systems, examines matrices and membrane-controlled reservoir systems, evaluates polymers as drug delivery carriers, and describes peptide, protein, micro, and nanoparticulate release systems. Catalog no. DK1638, ISBN: 978-0-8247-0369-1 2001, 7 x 10, 902 pp. Suggested Price: $279.95 / £156.00

Merck, Inc., West Point, Pennsylvania, USA

Using concise language along with numerous case studies, examples, tables, flow charts, and schematics, Process Scale Bioseparations for the Biopharmaceutical Industry brings together scientific principles, empirical approaches, and practical considerations for designing industrial downstream bioprocesses for various classes of biomolecules. Experienced professionals in purification processes and industrial downstream unit operations provide experimental design strategies and guidelines for developing application-specific process scale bioseparations. They also consider analytical methods, viral validation, regulatory aspects, and emerging areas such as high gradient magnetic fishing for capture. Catalog no. DK3347, ISBN: 978-1-57444-517-6 2007, 6 x 9, 575 pp. Suggested Price: $185.95 / £103.00

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Biopharmaceuticals / Drug Discovery & Development

Understanding Drug Release and Absorption Mechanisms

A Physical and Mathematical Approach

Biochips as Pathways to Drug Discovery Edited by

Andrew Carmen

Illumina, Inc., San Diego, California, USA

Mario Grassi, Gabriele Grassi, Romano Lapasin, and Italo Colombo

Gary Hardiman

University of Trieste, Italy

Series: Drug Discovery Series

Developing realistic and reliable models of drug release requires crossdisciplinary physical, mathematical, and physiological knowledge. This book brings together these areas into a single source and builds a firm foundation of all the elements needed to conceive, build, and implement successful models of drug release. The authors first introduce the basics of modeling, relevant physiology, rheology, mass transport and thermodynamics, dissolution and partitioning, and drug solubility dependence on drug crystal size. Subsequent chapters explore applications in drug release from various delivery systems, specifically matrix systems, microemulsions, and permeability through membranes.

Providing a comprehensive and real-world examination of biochip technologies, this book goes on to explore their applications to drug discovery. The book presents a detailed overview of the current state of biochip technology, examining the effects of biochips on biomedical research and specifically, the pharmaceutical industry. It includes detailed discussions of technology platforms and explores the clinical relevance of biochips, ChIP-chip assays, and highthroughput approaches. It also covers intellectual property concerns and includes applications to the study of disease, drug-safety and toxicogenomics, and pharmacogenomics and SNPs (Single Nucleotide Poymorphisms).

Catalog no. 3087, ISBN: 978-0-8493-3087-2 2007, 6-1/8 x 9-1/4, 648 pp. Suggested Price: $144.95 / £79.99

Catalog no. DK3227, ISBN: 978-1-57444-450-6 2007, 6-1/8 x 9-1/4, 386 pp. Suggested Price: $154.95 / £86.00

Antisense Drug Technology

Chemical Information Mining

98 Principles, Strategies, and

University of California at San Diego, USA

Applications, Second Edition

Facilitating Literature-Based Discovery

Edited by

Stanley T. Crooke

Debra L. Banville

Extensively revised and updated, this second edition incorporates lessons learned from first generation clinical trials, evaluates the technology as a whole, and offers new directions and avenues of research and development. The book explains mechanisms of action, pharmacokinetics of delivery, and the therapeutic potential of antisense drugs, ologonucleotides, hybridization-based drugs, duplex RNA, and more. Leading researchers discuss improvements to second generation drugs and consider the potential of antisense drugs for the alleviation of cardiovascular, metabolic, and inflammatory diseases; cancer; neurological disorders; and immune modulation.

This volume focuses on information extraction issues, highlights available solutions, and underscores the value of these solutions to academic and commercial scientists. After introducing the drivers behind chemical text mining, the book discusses chemical semantics. The contributors describe the tools that identify and convert chemical names and images to structure-searchable information. They also explain natural language processing, name entity recognition concepts, and semantic web technologies. Following a section on current trends in the field, the text looks at where information mining approaches fit into the research needs within the life sciences.

Catalog no. 8796, ISBN: 978-0-8493-8796-8 2008, 7 x 10, 848 pp. Suggested Price: $239.95 / £133.00

Catalog no. 76493, ISBN: 978-1-4200-7649-3 January 2009, 6-1/8 x 9-1/4, 208 pp. Suggested Price: $99.95 / £55.99

ISIS Pharmaceuticals Inc., Carlsbad, California, USA

AstraZeneca Pharmaceuticals, Wilmington, Delaware, USA

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Combination Products

Smita Gopalaswamy

Advanced Solutions Consultants, Inc., Parkland, Florida, USA

Dictionary of Marine Natural Products with CD-ROM Edited by

Venky Gopalaswamy

John W. Blunt and Murray H.G. Munro

The field of combination product development is so new that very few publications, including FDA documents, are available. This text provides an overview of the process from start to finish, complete with relevant definitions, and then shows how to establish a design and development plan. It provides an overview of FDA and other regulatory expectations and covers resource requirements, manufacturing, pitfalls, post-launch compliance requirements, and agency audits and challenges. The book presents practical guidelines on how to develop combination products successfully and how to implement them into the market successfully and in a timely manner.

Focusing for the first time on more than 25,000 marine-specific natural products, Dictionary of Marine Natural Products with CD-ROM indexes each product by chemical name, organism type, and compound type. Following a similar format to the Chapman & Hall Chemical Database, this comprehensive volume is mirrored on an accompanying CD-ROM that is fully text and structuresearchable. Each entry includes biological source, chemical structure, physical properties, biological activity, and literature references. This tool offers information essential to the development of novel pharmaceuticals, pesticides, and marine anti-fouling agents derived from unique molecular structures of marine natural products.

Catalog no. 64460, ISBN: 978-1-4200-6446-9 2008, 6-1/8 x 9-1/4, 264 pp. Suggested Price: $139.95 / £77.99

Catalog no. 8216, ISBN: 978-0-8493-8216-1 2008, 8-1/2 x 11, 2536 pp. Suggested Price: $599.00 / £333.00

Johnson and Johnson, New Brunswick, New Jersey, USA

Design and Use of Relational Databases in Chemistry TJ O’Donnell

President, gNova Inc., San Diego, California, USA

University of Canterbury, Christchurch, New Zealand

Functional Protein Microarrays in Drug Discovery

Drug Discovery & Development

Regulatory Challenges and Successful Product Development

Edited by

Paul F. Predki

Invitrogen, Branford, Connecticut, USA Series: Drug Discovery Series, 8

Through many examples of good database design, this book shows that relational databases are the best way to store, search, and operate on chemical information. Introducing the concepts of RDMS and SQL, the author describes how relational data tables and new data types help store and use chemical information, how molecular structures can become a new data type in a database, and how client programs can effectively use relational databases. He also explains how a fully functioning chemical relational database system can be built. A supplementary website offers an implementation of every function from the book, a database of structures and data, and examples used in the book.

An ideal text for biotechnologists, protein chemists, and biochemists, Functional Protein Microarrays in Drug Discovery explores all aspects of functional protein microarrays, including basic principles, methods, and applications. The book discusses the generation of functional protein content and describes both standard and state-of-the-art fabrication methods. It reviews current and next generation approaches to assay detection and presents a wide range of applications, from biomolecular interaction discovery and characterization to immune response profiling. The book also addresses several fundamental computational issues, bioinformatics and data analysis.

Catalog no. 64428, ISBN: 978-1-4200-6442-1 January 2009, 6-1/8 x 9-1/4, 224 pp. Suggested Price: $129.95 / £72.99

Catalog no. 9809, ISBN: 978-0-8493-9809-4 2007, 6-1/8 x 9-1/4, 480 pp. Suggested Price: $175.95 / £98.00

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For more information and a complete list

Gene Profiles in Drug Design Edited by

Drug Discovery & Development 100

Brett A. Lidbury and Suresh Mahalingam

University of Canberra, Australia

Handbook of Assay Development in Drug Discovery Edited by

Lisa K. Minor

Johnson & Johnson Pharmaceutical Research & Development, LLC, Springhouse, Pennsylvania, USA Series: Drug Discovery Series, 5

Featuring contributions from leaders in a number of fields, Gene Profiles in Drug Design explores the processes and technologies that yield gene profile-based drugs. Each chapter focuses on one component or step in the process of translating abstract gene profiles into tangible new drugs. The first part of the text compares the advantages and pitfalls of various methods that have been used to generate gene profiles. The next section discusses current uses of gene profiles in drug design, including lead identification. The book concludes with a look at emerging technologies that use gene profiles to design high specificity drugs. Catalog no. DK6021, ISBN: 978-0-8493-3733-8 January 2009, 6-1/8 x 9-1/4, 160 pp. Suggested Price: $139.95 / £77.99

Handbook of Analytical Validation Ira S. Krull

Northeastern University, Boston, Massachusetts, USA

The Handbook of Assay Development in Drug Discovery describes all the tools currently available for performing various assay techniques. Featuring troubleshooting advice for common problems from experienced assay developers, the vendor community, and scientists in the pharmaceutical industry, the book presents descriptions of methods, laboratory guidelines and protocols used to perform such methods, specific examples of each assay system, and troubleshooting tools. Designed as a guide to running an assay from start to finish, this is an ideal reference for scientists involved in drug discovery screening, lead profiling, therapeutic target evaluation, and assay development and implementation. Catalog no. DK3264, ISBN: 978-1-57444-471-1 2006, 7 x 10, 488 pp. Suggested Price: $154.95 / £86.00

High-Throughput Analysis in the Pharmaceutical Industry Edited by

Perry G. Wang

Michael E. Swartz

Teleflex, Wyomissing, Philadelphia, USA

Synomics Pharmaceuticals Services LLC, Wareham, Massachusetts, USA

Series: Critical Reviews in Combinatorial Chemistry

Written for researchers in both the drug and biotechnology industries, the Handbook of Analytical Validation carefully compiles the current regulatory requirements that must be followed in order to correctly and properly validate a new or modified analytical method. It contains practical, up-to-date guidelines and includes coverage of areas such a quality control, cleaning validation, and R&D validation. Leading readers through the steps required by all major regulatory agencies, the book is applicable to both small molecules in the conventional pharmaceutical industry, as well as for biopolymers derived from the biopharmaceutical industry.

High throughput analysis plays a critical role in the pharmaceutical industry. The ever-shortening timelines and increased costs of drug discovery and development have brought about the need for high throughput approaches to methods that are currently used in the industry. Written and edited by well-known contributors who remain active in this line of research, this book systematically describes high throughput analysis for the pharmaceutical industry, including advanced instrumentation and automated sample preparation. The text discusses various techniques, including HPLC, MALDI-MS, and LC-MS/MS methods, with an emphasis on the later stage of drug development, including pharmacokinetics.

Catalog no. DK2235, ISBN: 978-0-8247-0689-0 June 2009, 6-1/8 x 9-1/4, 350 pp. Suggested Price: $169.95 / £103.00

Catalog no. 5953X, ISBN: 978-1-4200-5953-3 January 2009, 7 x 10, 432 pp. Suggested Price: $159.95 / £89.00

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

High-Throughput Lead Optimization in Drug Discovery Tushar Kshirsagar

Medicinal Chemistry

Series: Critical Reviews in Combinatorial Chemistry

V. K. Ahluwalia and Madhu Chopra

A single source on parallel synthesis for lead optimization, this book features real-world examples and contributions from wellknown scientists. It explores the shift to conducting parallel lead optimization in-house while outsourcing most of the screening libraries synthesis. With more than 15 case studies that encompass a range of biological targets, the text contains examples of solid and solution-phase techniques for the synthesis of directed libraries. The contributors explain the design principles they used to direct the choice of templates and diversity elements, and they explore how this technology, when applied to library design, can speed up drug discovery.

This book gives a concise introduction to the chemistry of therapeutically active compounds. Written in a readable style that makes the information easily accessible, the book includes a brief review of the drug development timeline from the discovery to the final product. With emphasis on the description of their pharmacological effects, the content is organized by drug class. Coverage includes existing drugs, their biological properties, and their quantitative structure-activity relationship. Primarily intended for the students and professionals in the pharmaceutical industry, Medicinal Chemistry assumes little prior knowledge on the subect, making it ideal for classroom and training seminar use.

Catalog no. 7268, ISBN: 978-0-8493-7268-1 2008, 7 x 10, 256 pp. Suggested Price: $149.95 / £83.00

Catalog no. AB6580, ISBN: 978-1-4200-6580-0 2008, 6-1/8 x 9-1/4 Suggested Price: $104.95 / £57.99

Index Nominum

Methods in Microarray Normalization

3M Pharmaceuticals, St. Paul, Minnesota, USA

International Drug Directory, Nineteenth Edition

University of Delhi, India

Drug Discovery & Development

Edited by

101

Edited by

Phillip Stafford

Edited by

Arizona State University, Tempe, USA

Swiss Pharmaceutical Society Stuttgart, Germany

Series: Drug Discovery Series

After 50 years, this authoritative index continues to reign as the standard international pharmaceutical reference on medications, proprietary names, synonyms, chemical structures, and therapeutic classes of substances. This 19th edition offers improved search functionality and includes 70,000 proprietary names (19,000 more than the previous edition) from more than 12,000 manufacturers representing 171 countries. It also contains an updated and edited collection of active substances and derivatives (4,000 total) with international non-proprietary names (INN) and 12,000 synonyms. An accompanying CD-ROM provides more than 12,000 addresses and links to pharmaceutical manufacturers worldwide.

This organized text compiles for the first time the most useful normalization methods developed for interpreting microarray data. Experts examine the mathematical processes that are important in normalizing data and avoiding inherent systematic biases. They also review modern software, including discussions on key algorithms, comparative data, and download locations. The book contains the latest microarray innovations from companies such as Agilent, Affymetrix, and GeneGo as well as new, readily adaptable normalization methods for expression and CGH arrays.It also provides lists of open-source molecular profiling normalization algorithms available and reveals where to access them.

Catalog no. V5042, ISBN: 978-3-8047-5042-5 2008, 9 x 12, 1982 pp. Suggested Price: $395.00

Catalog no. 52780, ISBN: 978-1-4200-5278-7 2008, 6-1/8 x 9-1/4, 304 pp. Suggested Price: $79.95 / £44.99

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For more information and a complete list

Pharmaceutical Chemical Analysis Drug Discovery & Development 102

Methods for Identification and Limit Tests

A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery Taosheng Chen

Memphis, Tennessee, USA

Ole Pedersen

Series: Critical Reviews in Combinatorial Chemistry

In recognition of the scarce availability of information on European pharmacopoeia testing methods, this text explains the purpose, chemistry involved, and analytical tests behind these older, yet standard tests. The tests detailed are often cheaper and simpler than newer tests but equally reliable. The book covers tests for the identification of ions, functional groups tests, and limit tests. It explains the procedural steps for each test augmented with illustrations, formulas, reaction information, and a listing of strengths and weaknesses in terms of specificity, ruggedness, and potential procedural pitfalls.

Few scientists have access to the multidisciplinary experience needed for successful assay development and high-throughput screening (HTS) in drug discovery. Designed to give researchers a boost, this text integrates the experience of diverse experts who offer fundamental practical guidance across numerous situations. It introduces emerging technology that allows scientists to identify and capture relevant information. The author instructs on how to initiate, validate, optimize, and manage a bioassay intended to screen large collections of compounds. The book also identifies critical targets of relevance in drug discovery and treats each individually in terms of the parameters needed for successful assay development.

Quality Control GEA Ltd., Hvidovre, Denmark

Catalog no. PH1978, ISBN: 978-0-8493-1978-5 2006, 6-1/8 x 9-1/4, 176 pp. Suggested Price: $195.95 / £109.00

Pharmaceutical Packaging Technology Edited by

D.A. Dean, E.R. Evans, and I.H. Hall

Catalog no. 70509, ISBN: 978-1-4200-7050-7 July 2009, 7 x 10, 352 pp. Suggested Price: $159.95 / £97.00

Process Chemistry in the Pharmaceutical Industry Edited by

Kumar G. Gadamasetti

Fisons Place, Ipswich, UK

Delphian Pharmaceuticals, Belmont, California, USA

Pharmaceutical packaging is regarded as an integral part of the end pharamaceutical/drug product. Pharmaceutical Packaging Technology is structured to meet the needs of the global market, and brings together a wide range of current knowledge. This volume caters to the requirements of the established pharmaceutical industry, as well as pharmaceutical companies in emerging nations, which are still seeking a basic grounding on the subject. The contributors integrate information on many drug delivery systems, where the packaging is an essential component of the product.They discusses testing and evaluation and emphasize traceability and the need to for strong safeguards.

An ideal guide for scientists entering pharmaceutical discovery and development, this reference also clarifies the roles of various specialties in of new drug development. Featuring contributions from nearly 50 renowned researchers and over 1000 references, tables, and illustrations, it offers a solid grounding in synthetic as well asphysical organic chemistry. This seminal volume highlights new strategies for aggressive drug development programs, green synthesis processes, and other trends in the industry. It illustrates the impact of non-traditional small molecules as a therapeutic agent, and includes 12 case studies on agents such as inhibitors and antangonists.

Catalog no. RU34317, ISBN: 978-0-7484-0440-7 2001, 646 pp. Suggested Price: $409.95 / £228.00

Catalog no. DK2505, ISBN: 978-0-8247-1981-4 1999, 7 x 10, 500 pp. Suggested Price: $229.95 / £128.00

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Process Chemistry in the Pharmaceutical Industry Volume 2 Challenges in an Ever Changing Climate

Textbook

Textbook of Drug Design and Discovery

Kumar Gadamasetti

Delphian Pharmaceuticals, Belmont, California, USA

Tamim Braish

Pfizer Global Research & Development, Groton, Connecticut, USA

Defying the misconception of process chemistry as mere scale-up work, this volume explores the most up-to-date process research and development methods applied to synthesis, clinical trials, and commercial drug candidates. It discusses new approaches to synthetic processes, examines the latest safety methods and design experiments, and suggests realistic solutions to problems encountered in manufacturing and process development. Topics include new synthesis methods, instrumentation, automization, quality control, cost considerations, regulatory issues, outsourcing, green practices, and future trends. Case studies demonstrate strategies for aggressive drug development programs. Catalog no. 9051, ISBN: 978-0-8493-9051-7 2008, 7 x 10, 520 pp. Suggested Price: $259.95 / £144.00

Quantitative Drug Design A Critical Introduction, Second Edition Yvonne C. Martin

Ulf Madsen, Povl Krogsgaard-Larsen, and Kristian Stromgaard Danish University of Pharmaceutical Sciences, Copenhagen, Denmark

Updated and revised, this fourth edition of a perennial bestseller provides current and comprehensive information on all aspects of drug design and discovery. It describes the specific strategies employed by medicinal chemists to advance promising molecules into clinical use for the alleviation of disease. The book includes new chapters on products of natural origin as leads in drug design, chemical biology, ADME-tox properties, bioinformatics and chemoinformatics in drug research. It also explores combinatorial chemistry, parallel synthesis, high-throughput screening, imaging in drug design, computer modeling techniques, gene technology, and target validation. Catalog no. 63227, ISBN: 978-1-4200-6322-6 June 2009, 7 x 10, 400 pp. Suggested Price: $79.95 / £48.99 Also Available in Soft Cover

Thermal Analysis of Pharmaceuticals

103

Edited by

Duncan Q.M. Craig and Mike Reading

Abbotts Lab (Retired), Waukegan, Illinois, USA

University of East Anglia, Norwich, UK

This volume teaches readers how to apply traditional ligand-based quantitative drug design methods as a complement to recent 3D macromolecular structure-based methods. Requiring only a modest training in chemistry, the book begins at an introductory level and builds into areas of greater complexity. Each subject is treated in enough detail such that readers can apply the method to their own data. This book presents a comprehensive integration of physical and computational chemistry, physical biochemistry, physical organic chemistry, and statistics at understandable levels.

This book presents reliable and versatile characterization tools for the successful development of pharmaceutical products. It highlights the ability of thermal methods to characterize almost any sample, remain inexpensive, and be operator-friendly. The book focuses on the most widely applicable methods and demonstrates how to interpret the associated data. It covers differential scanning calorimetry (DSC), modulated temperature DSC, thermogravimetric analysis, thermal microscopy, microcalorimetry, high sensitivity DSC, dynamic mechanical analysis, and thermally stimulated current. The chapters include theoretical background, measurement optimization, and pharmaceutical applications for each technique.

Catalog no. 70991, ISBN: 978-1-4200-7099-6 July 2009, 6-1/8 x 9-1/4, 464 pp. Suggested Price: $129.95 / £78.99

Drug Discovery & Development

Fourth Edition

Edited by

Catalog no. DK2980, ISBN: 978-0-8247-5814-1 2007, 6-1/8 x 9-1/4, 416 pp. Suggested Price: $154.95 / £86.00

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For more information and a complete list Drug Discovery & Development / Manufacturing & Quality Assurance 104

Handbook of Microbiological Quality Control Water-Insoluble Drug Formulation Second Edition Edited by

Pharmaceuticals and Medical Devices Edited by

Rosamund M. Baird University of Bath, UK

Norman A. Hodges

Rong Liu

AustarPharma, Edison, New Jersey, USA

Scientists have attributed more than 41% of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility The most comprehensive resource on the topic, this volume brings together a distinguished team of experts to provide step-by-step guidance on drug and water properties. Twenty-three chapters systematically describe solubility properties and their impact on formulation, from theory to industrial practice. With detailed discussion on how they contribute to solubilization and dissolution, the text also features three brand new chapters on water-insoluble drugs, exploring regulatory aspects, pharmacokinetic behaviors, and formulation strategies. Catalog no. 9644, ISBN: 978-0-8493-9644-1 2008, 7 x 10, 688 pp. Suggested Price: $299.95 / £167.00

Fate of Pharmaceuticals in the Environment and in Water Treatment Systems

University of Brighton, UK

Stephen P. Denyer Cardiff University, UK

This volume offers a wealth of microbiological information not only on the practical issues facing the company microbiologist today, but also on the underlying principles of microbiological quality assurance. Written by leading experts in the field, The Handbook of Microbiological Quality Control: Pharmaceuticals and Medical Devices is the essential reference source for the professional microbiologist. It provides guidance on safe microbiological practices, including laboratory design and sampling techniques, and considers in depth the design, storage, use, and quality control of microbiological culture. Catalog no. TF2047, ISBN: 978-0-7484-0614-2 2001, 7 x 10, 280 pp. Suggested Price: $179.95 / £97.00

Laboratory Quality Assurance Manual and Templates Edited by

Donnell R. Christian, Jr.

Professional Business Solutions, Chesterfield, Missouri, USA

Edited by

Stephanie Drilling

Diana S. Aga

Series: International Forensic Science and Investigation

Written by experts from academia, government, and industry, Fate of Pharmaceuticals in the Environment and in Water Treatment Systems provides a multi-disciplinary perspective on the issues, discussing topics ranging from field studies documenting the occurrence of pharmaceuticals in environmental compartments, to laboratory studies determining the degradation kinetics and formation of by-products during treatment. The text provides data to help scientists, regulators, and engineers understand the factors that affect the environmental fate of pharmaceuticals in soil and water, develop best management practices, and optimize treatment systems for removal of these compounds from the environment.

Written by experts with global experience in setting up laboratories, this work provides templates for the various policies, procedures, and forms contained in a quality assurance manual of a laboratory seeking accreditation. It includes a criteria file that cross-references individual document templates to the corresponding accreditation criterion associated with ISO 17025. Originally developed for use in forensic laboratories, this material meets the standards of ISO 17025 and therefore has international applications for all laboratories. The book includes an interactive CD-ROM that can be customized to suit the purpose of any laboratory seeking accreditation.

University at Buffalo, New York, USA

Catalog no. 52322, ISBN: 978-1-4200-5232-9 2008, 6 x 9, 408 pp. Suggested Price: $144.95 / £79.99

Catalog no. 73044, ISBN: 978-1-4200-7304-1 July 2009, 7 x 10, 512 pp. Suggested Price: $795.00 / £539.00

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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Six Sigma in the Pharmaceutical Industry

Producing Biomolecular Substances with Fermenters, Bioreactors, and Biomolecular Synthesizers

Understanding, Reducing, and Controlling Variation in Pharmaceuticals and Biologics Brian K. Nunnally

William L. Hochfeld, Ph.D., C.Ch.E.

Wyeth Vaccines, Sanford, North Carolina, USA

This classic work presents unparalled, detailed, and cutting-edge information on bioprocessing systems. A working reference and formulary for producing recombinant, bioactive, or other exotic proteins, peptides, and nucleic acids to specification, the text provides coverage of the related technologies, coupled with the extensive biotechnology glossary, manufacturer’s directories, extensive references, important formulae, charts, illustrations, comprehensive index, emphasis on practical techniques, time-proven methods, and essential applications. These features combine with its ingenious, easy-to-use layout to make it the resource that readers will consult on a regular basis.

Wysol Pty Ltd, Queensland, Australia

Des Plaines, Illinois, USA

Catalog no. PH2270, ISBN: 978-0-8493-2270-9 2006, 6-1/8 x 9-1/4, 408 pp. Suggested Price: $209.95 / £117.00

Quality Assurance and Quality Control in the Analytical Chemical Laboratory A Practical Approach

Piotr Konieczka and Jacek Namiesnik

John S. McConnell

Six Sigma in the Pharmaceutical Industry is the first book to introduce the fundamentals of Six Sigma, examine control chart theory and practice, and explain the concept of variation management and reduction applied specifically to the pharmaceutical industry. The first half lays out a conceptual framework for understanding variation, while remainder introduces control chart theory and practice. Using case studies and statistics, the book illustrates the concepts and explains their application to actual workplace improvements. Offering a complete operating philosophy, this book focuses on core concepts and their implementation to improve the existing processes in the pharmaceutical industry. Catalog no. 54932, ISBN: 978-1-4200-5439-2 2007, 6-1/8 x 9-1/4, 224 pp., Soft Cover Suggested Price: $93.95 / £51.99

Manufacturing & Quality Assurance / Pharmaceutical Science

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

Pharmacoeconomics From Theory to Practice

105

Edited by

Renee J. G. Arnold

Gdansk University of Technology, Poland

Arnold Consultancy & Technology LLC, New York, USA

Series: Analytical Chemistry

Series: Drug Discovery Series

Clearly written and well-organized, this volume provides a thorough exploration of the concepts of practical QA/QC. Using an approach grounded in hands-on experience, the book begins with the theory behind quality control systems then moves on to discuss examples of such tools as validation parameter measurements, the use of statistical tests, counting the margin of error, and estimating uncertainty. The authors draw on their experience in uncertainty estimation, traceability, reference materials, statistics, proficiency tests, and method validation to craft a resource that provides practical guidance for each step of the process. A solutions manual is available for qualifying instructors.

An introduction to the major concepts and principles of pharmacoeconomics, Pharmacoeconomics: From Theory to Practice emphasizes modeling, methodologies, and data sources and explains how to apply them to real world dilemmas. This volume covers the international use of pharmacoeconomics in drug regulation, drug approval, and pricing. The book provides examples of pharmacoeconomic models used to support these purposes in government, the pharmaceutical industry, and healthcare settings. The book also demonstrates the full range of ethical, moral, public health, and commercial concerns that are often involved in decisions involving pharmacoeconomic issues.

Catalog no. 82701, ISBN: 978-1-4200-8270-8 February 2009, 6-1/8 x 9-1/4, 228 pp. Suggested Price: $129.95 / £78.99

Catalog no. 84224, ISBN: 978-1-4200-8422-1 June 2009, 6-1/8 x 9-1/4, 352 pp. Suggested Price: $119.95 / £72.99

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For more information and a complete list Adenosine Receptors Polysaccharides

Structural Diversity and Functional Versatility, Second Edition Edited by

Severian Dumitriu

University of Sherbrooke, Canada

Pharmacology

Completely revised and expanded to reflect the latest advancements in the field, this text outlines fundamental concepts in the structure, function, chemistry, and stability of polysaccharides and reveals new analytical techniques and applications currently impacting the cosmetic, medicinal, chemical, and biochemical industries. This authoritative book discusses polysaccharides utilized in medical applications such as polysaccharide-based hydrogels, polysialic acids, proteoglycans, glycolipids, and anticoagulant polysaccharides; renewable resources for the production of various industrial chemicals and engineering plastics polysaccharides; and more. Catalog no. DK1167, ISBN: 978-0-8247-5480-8 2005, 8-1/2 x 11, 1224 pp. Suggested Price: $309.95 / £172.00

Therapeutic Aspects for Inflammatory and Immune Diseases Edited by

Gyorgy Hasko

University of Medicine and Dentistry of New Jersey Medical School, Newark, USA

Bruce N. Cronstein

New York University School of Medicine, New York, USA

Csaba Szabo

Semmelweis University, Budapest, Hungary

An overview of how adenosine and inosine regulate immune responses, Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases covers aspects of molecular biology, cell biology, and pharmacology. It addresses the role of adenosine receptors in regulating the function of various cell types involved in immune responses. It features data derived from studies using cutting-edge techniques and discusses disease states such as autoimmune diseases, asthma, atherosclerosis, ischemia-reperfusion injury, and cancer. With contributions from international experts, the text is ideal for researchers in pharmaceutical companies, academic scientists, and clinicians. Catalog no. 3999, ISBN: 978-0-8493-3999-8 2007, 6-1/8 x 9-1/4, 363 pp. Suggested Price: $195.95 / £109.00

Anticancer Agents from Natural Products 106

Practical Guide to Clinical Data Management Second Edition Susanne Prokscha

Edited by

Gordon M. Cragg and David J. Newman

National Cancer Institute, Frederick, Maryland, USA

David G. I. Kingston

Redwood City, California, USA

Virginia Polytechnic Institute & State University, Blacksburg, USA

Examining the role of data management in clinical trials, Practical Guide to Clinical Data Management, Second Edition provides a solid introduction to the key process elements of clinical data management. It incorporates the modifications that data management groups have made under 21 CFR 11 and examines the differences in data management between EDC-based studies and paper-based studies. The second edition has been reorganized into three sections. Part I covers the basic data management tasks. Part II addresses the expectations of the FDA and auditors for how data management groups carry out their work in compliance with regulations. Part III focuses on the computer systems.

Edited by leading scientists who have contributed enormously to natural product development and potential anticancer natural products, Anticancer Agents from Natural Products presents a historical, biochemical, and chemical rationale to the search for a plant, marine, or microbial source that may provide future templates for drug lead optimization and synthetic drug design. An ideal foundation for scientists engaged in developing new and improved drugs based on natural sources, this text provides an analysis of the research and development of some of the most effective anticancer agents available that are natural products or clearly derived from natural product leads.

Catalog no. 7615, ISBN: 978-0-8493-7615-3 2007, 6-1/8 x 9-1/4, 256 pp. Suggested Price: $164.95 / £92.00

Catalog no. 1863, ISBN: 978-0-8493-1863-4 2005, 7 x 10, 600 pp. Suggested Price: $195.95 / £109.00

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Textbook

Robert S. Matson

Basic Pharmacology

Understanding Drug Actions and Reactions Maria A. Hernandez and Appu Rathinavelu

Nova Southeastern University, Fort Lauderdale, Florida, USA

Beckman Coulter Inc., Fullerton, California, USA

Series: Plant Engineering Series, 20

This volume evaluates current research using microarray technology in genomics and proteomics, providing practical tips on its employment in drug discovery and development. The book details the commercial landscape, critically assessing those studies that have helped define applications in genomics and proteomics, explains gene expression microarray applications, and examines the utility of the protein microarray. It covers alternative substrates, examines the preparation of various surface chemistries, and looks at their suitability for immobilizing nucleic acids and proteins. It also explains the mechanics, including printer and pin performance; and supplies printing protocols.

Written as an introductory pharmacology text, Basic Pharmacology: Understanding Drug Actions and Reactions provides the indepth discussion of the chemical and molecular pharmacology fundamentals that pharmacy students require to move on to more advanced study. The book covers the principles of chemistry and biology necessary to understand drug action at the cellular level. It emphasizes the chemical and physical properties of drugs, drug absorption and distribution, drug interactions with cellular receptors, and drug metabolism and interactions. With extensive use of model drug structures, it effectively explains chemical and molecular pharmacology principles.

Catalog no. 1469, ISBN: 978-0-8493-1469-8 2005, 6-1/8 x 9-1/4, 256 pp. Suggested Price: $185.95 / £103.00

Catalog no. TX605, ISBN: 978-1-58716-160-5 2006, 6-1/8 x 9-1/4, 369 pp. Suggested Price: $78.95 / £43.99

Pharmacology

Applying Genomic and Proteomic Microarray Technology in Drug Discovery

Textbook

Basic Pharmacokinetics Mohsen A. Hedaya Tanta University, Egypt

107

Bioactive Peptides John Howl and Sarah Jones

Series: Plant Engineering Series

University of Wolverhampton, UK

An accessible introduction to foundational concepts, Basic Pharmacokinetics has been carefully designed for students and others who have never studied the subject before. Exploring the use of mathematical models to predict the response of individual patients to drugs, this book features a CD-ROM that complements the material presented in the text. The CD-ROM includes computerbased presentations that use graphics and simulations to allow readers to visualize how a change in one or more pharmacokinetic parameter is reflected in the drug profile of the body. Using a selfinstructional format, this text serves as a useful reference covering such topics as drug absorption and therapeutic drug monitoring.

Answering a long-standing need in the pharmaceutical and biotechnology fields, this definitive reference focuses on the biology, pharmacology, and therapeutic applications of endogenous peptide mediators and their analogues. The book takes peptide science beyond chemical synthesis strategies and into the realms of peptide biology and therapeutics. It presents the overall contribution peptide science has made to molecular, cellular and whole organism biology, while discussing future targets and therapeutic applications. With the mounting worldwide interest in the therapeutic potential of peptides, this is an indispensable work for researchers.

Catalog no. 46713, ISBN: 978-1-4200-4671-7 2007, 6-1/8 x 9-1/4, 328 pp. Suggested Price: $83.95 / £46.99

Catalog no. 61143, ISBN: 978-1-4200-6114-7 April 2009, 7 x 10, 512 pp. Suggested Price: $179.95 / £109.00

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For more information and a complete list

Bitter Nemesis

The Intimate History of Strychnine John Buckingham

Chemistry and Molecular Aspects of Drug Design and Action Edited by

Pharmacology

Consultant Editor, Dictionary of Natural Products, London, UK

E.A. Rekka and P.N. Kourounakis

Bitter Nemesis: The Intimate History of Strychnine is the first book to chronicle the history and impact of strychnine, from its discovery to the present time. The author compiles a scholarly, yet compelling account of this fascinating chemical substance, bringing forth an extraordinary mix of original research spanning the realms of history, medicine, literature, chemistry, and forensics. The text explores strychnine’s trial-and-error contributions to scientific, medical, and forensic developments. It also investigates the perception of strychnine in popular culture—from criminal notoriety to accidental misuse to appearances in fiction.

Drawn from the work of world-renowned pharmacochemistry scientists, this book explores research that defines the emergence of rational drug design. Offering insight from their own specialized subjects, these pioneers highlight the variety of approaches being employed in this field, including those that start by considering either molecular mechanisms of drug action, or the metabolizing enzyme action occurring in the structure of a drug molecule. Another approach they explore is one that starts from the pathobiochemistry and pathophysiology of target diseases. The book also considers drug development that makes use of already developed compounds stored in data banks.

Catalog no. 53159, ISBN: 978-1-4200-5315-9 2008, 6-1/8 x 9-1/4, 320 pp., Soft Cover Suggested Price: $41.95 / £22.99

Aristotelian University of Thessaloniki, Greece

Catalog no. 9006, ISBN: 978-0-8493-9006-7 2008, 6-1/8 x 9-1/4, 384 pp. Suggested Price: $179.95 / £99.00

Chemical Warfare Agents

108

Chemistry, Pharmacology, and Therapeutics, Second Edition Edited by

James A. Romano, Jr. and Brian J. Lukey U.S. Army Medical Research and Material Command, Fort Detrick, Maryland, USA

Harry Salem

U.S. Army Chemical and Biological Center, Aberdeen, Maryland, USA

This updated edition is designed to help first responders prepare for and supply the best treatment for natural disasters, chemical spills, terrorism, and warfare situations. Leading researchers offer a first-hand look at the progress made in chemical defense research since 2001. The book explores the evolution of concepts, tests, and products for preventing, diagnosing, and treating the acute and chronic effects of toxic CWA exposure. It provides details on the latest studies and countermeasure developments—such as new barrier creams and bioscavengers—and discusses better risk assessment tools, more organized emergency response protocols, and more effective decontamination procedures. Catalog no. 46616, ISBN: 978-1-4200-4661-8 2008, 7 x 10, 752 pp. Suggested Price: $164.95 / £92.00

Chemistry and Pharmacology of Anticancer Drugs David E. Thurston

University of London, UK

Following a review of cancer causes and progression, current treatments, and the philosophy of drug discovery, this comprehensive work surveys anticancer agents currently in use or in advanced stages of clinical trials, including biological agents. Ideal for those involved in anticancer drug research, the book provides molecular structures for each agent and discusses their history, chemistry, mechanisms of action, structure-function relationships, relevant pharmacology, cytotoxicity, side effects, and formulation issues. It also discusses new research tools, methodologies, tumor-targeting strategies, and the emerging areas of oncogenomics and chemoprevention. Catalog no. 9219, ISBN: 978-0-8493-9219-1 2007, 6-1/8 x 9-1/4, 312 pp. Suggested Price: $175.95 / £98.00

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

Dictionary of Drugs on CD-ROM

Desk Reference of Clinical Pharmacology

With PDR® GenericsTM Edited by

Second Edition

C.R. Ganellin

Manuchair Ebadi

University of North Dakota, Grand Forks, USA

David J. Triggle

State University of New York at Buffalo, USA

Designed specifically for physicians and other healthcare professionals, Desk Reference for Clinical Pharmacology: Second Edition features complete yet concise descriptions of the properties of every drug used in clinical practice. The book presents brief A to Z drug facts and provides short reviews of such topics as drugdrug interaction, adoptive immunotherapy, antisense therapeutics, drug metabolism and transport, as well as pharmacogenomics. The book also features discussions on diseases and treatment as well as comprehensive tables on the current uses of antibiotics in medicine.

Presenting nearly 13,200 entries with accurate, up-to-date and concise information on more than 48,500 compounds, the Dictionary of Drugs on CD-ROM is a one-stop resource for the medicinal chemist. As well as chemical and structural data, this searchable database also offers mechanisms of drug action, octanol/water partition coefficients, marketing status, and literature references to pharmacological studies. In addition, for the top 1500 drugs, monographs are hyperlinked from the renowned PDR® (Physician’s Desk Reference) Generics™, providing a wealth of pharmacokinetic and pharmacological data

Catalog no. 47434, ISBN: 978-1-4200-4743-1 2008, 8-1/2 x 11, 824 pp. Suggested Price: $169.95 / £98.00

Catalog no. C8760, ISBN: 978-0-412-78760-7 2008, 2700 pp., CD-ROM Suggested Price: $2795.00 / £1553.00

Dictionary of Alkaloids

Drug Synergism and Dose-Effect Data Analysis

Second Edition with CD-ROM Edited by

Pharmacology

Series: Desk References

University College London, UK

109

John Buckingham, Keith Baggaley, Andy Roberts, and Laszlo F. Szabo

Ronald J. Tallarida

Semmelweis University, Budapest, Hungary

Temple University, Philadelphia, Pennsylvania, USA

While some of the most commonly investigated—and most notorious—chemicals in the world are alkaloids, many modern medicines are also based on alkaloid structures. Chemists continue to explore new synthetic routes and alkaloid derivatives in search of drug candidates for fighting disease. This comprehensive dictionary documents and categorizes all known alkaloids. Drawn from the authoritative Dictionary of Natural Products, it presents concise chemical, structural, and physical data on 24,000 alkaloids. Each entry also includes biological sources and activity, chemical structure, physical properties, and literature references. A searchable CD-ROM version of the database also accompanies this volume.

Not since this author’s best-selling Manual of Pharmacologic Calculation has there been an available reference for drug data analysis. Incorporating the most relevant parts of that work, Drug Synergism and Dose-Effect Data Analysis focuses on drug combinations and all the quantitative analyses needed to analyze drug combination dose-effect data and to design experiments with two or more compounds. The book contains the statistical methods, the theory, and the computation algorithms needed to analyze single and combination drug data. Numerous examples accompany a presentation that illustrates the calculations and experimental design considerations for modern drug analysis.

Catalog no. 77694, ISBN: 978-1-4200-7769-8 July 2009, 8-1/2 x 11, 2200 pp. Suggested Price: $695.00 / £418.00

Catalog no. C0457, ISBN: 978-1-58488-045-5 2001, 6-1/8 x 9-1/4, 264 pp. Suggested Price: $79.95 / £39.99

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For more information and a complete list

Enhancement in Drug Delivery Elka Touitou

Handbook of Venoms and Toxins of Reptiles

The Hebrew University, Jerusalem, Israel

Edited by

Brian W. Barry

Stephen P. Mackessy

Enhancement in Drug Delivery offers an accessible compendium covering a wide spectrum of methods to enhance drug delivery and absorption by various routes of administration. Drawing from a number of disciplines, it gives students and practitioners in pharmaceutics, medicine, and health-related disciplines a muchneeded guide to current practices. It also provides a starting place for those working on delivery systems for new drugs or seeking to improve current systems by drawing on means applied in other routes. Organized by routes of delivery, the book covers oral, rectal, buccal and sublingual, dermal and transdermal, ocular, vaginal and uterine, nasal and brain administrations.

Bringing together contributions from many of the world’s leading experts in toxinology, the Handbook of Venoms and Toxins of Reptiles covers a broad range of topics relevant to a wide range of professionals including clinicians, biomedical researchers, herpetologists, and zoologists, as well as pharmacologists and evolutionary scientists. It discusses phylogeny and gland structure, venom enzymes and toxins, non-protein venom components, and envenomation and its treatment, including ideal treatments contrasted with those which are actually available in specific areas of the world. The text also addresses venom enzymes and assay procedures used to detect venoms along with venom toxins.

Catalog no. 3203, ISBN: 978-0-8493-3203-6 2007, 7 x 10, 656 pp. Suggested Price: $209.95 / £117.00

Catalog no. 9165, ISBN: 978-0-8493-9165-1 June 2009, 7 x 10, 512 pp. Suggested Price: $129.95 / £78.99

Edited by

University of Bradford, West Yorkshire, UK

Pharmacology

Handbook of CellPenetrating Peptides

110 Second Edition Edited by

Ulo Langel

University of Northern Colorado, Greeley, USA

Ibuprofen

A Critical Bibliographic Review

Stockholm University, Sweden

Edited by

Series: Pharmacology and Toxicology: Basic and Clinical Aspects, 3

K.D. Rainsford

In this second edition, the contributors summarize the current state of the field including recent reevaluations of earlier studies of CPP mechanisms. Beginning with an overview of the classes of peptides and their individual uptake mechanisms, the text then covers the use of CPPs in gene modulation, and the targeting of specific tumors and other tissues-questions that had barely been asked when the first edition was published. By summarizing the diffuse information regarding CPPs, including the ambiguities and variety of mechanisms, this book provides the most solid foundation available from which to expand the potential of this rapidly growing field of medicine.

This reference work provides a comprehensive and critical review of the basic science and clinical aspects of ibuprofen. The book begins with the history and development of the drug and its current patterns of use worldwide before moving on to examine its basic pharmaceutical attributes and medicinal chemistry. The book discusses the properties of various formulations, the pharmacokinetics, the clinical pharmacology and toxicology, and the drug’s mechanisms of action in different disease states and conditions. It also examines therapeutic use in various acute and inflammatory conditions, and considers safety versus efficacy issues, as well as pharmacoepidemiological data.

Catalog no. 5090, ISBN: 978-0-8493-5090-0 2007, 6-1/8 x 9-1/4, 600 pp. Suggested Price: $209.95 / £117.00

Catalog no. TF2097, ISBN: 978-0-7484-0694-4 1999, 6 1/8 x 9 1/4, 595 pp. Suggested Price: $239.95 / £133.00

Sheffield, Hallam University, Sheffield, UK

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Instrumental Data for Drug Analysis Third Edition 6 Volume Set

Medication Treatments for Nicotine Dependence

Terry Mills, III, James Conrad Roberson, Christian C. Matchett, Mathew J. Simon, Mark D. Burns, and Robert J. Ollis, Jr.

Edited by

Tony P. George

Finding detailed information on the analysis of drug-related compounds is challenging at best. This latest edition is an extensive six-volume set that contains over 6500 spectra on more that 1750 illicit and prescription drugs. It presents data on the six most popular analytical techniques used today: ultraviolet (UV) spectroscopy, infrared (IR) spectrometry, nuclear magnetic resonance (NMR) spectrometry, mass spectrometry (MS), gas chromatography (GC), and high pressure liquid chromatography (HPLC). This edition also presents the latest analytical techniques of FT-Ramen Spectra. Drugs are alphabetized and a combined index permits easy reference. Catalog no. 1974, ISBN: 978-0-8493-1974-7 2006, 8-1/2 x 11, 4688 pp. Suggested Price: $1295.00 / £695.00

Textbook

Offering a broad range of information, Medication Treatments for Nicotine Dependence is the first book of its kind in the field of medications for tobacco treatment. It assembles contributions from some of the leading basic and clinical scientists in the nicotine and tobacco dependence research community and comprehensively reviews currently available and novel medication approaches to treatment of nicotine dependence. This volume explores the basic pharmacology and physiology of nicotine and nicotinic receptors, examines first-line approved medications for nicotine, discusses second-line medications, and addresses special topics such as the combination of medications with behavioral treatments. Catalog no. 3779, ISBN: 978-0-8493-3779-6 2007, 6-1/8 x 9-1/4, 327 pp. Suggested Price: $154.95 / £86.00

Nanotechnology for Cancer Therapy

Introduction to Pharmacology

Pharmacology

Yale University School of Medicine, New Haven, Connecticut, USA

111

Edited by

Third Edition

Mansoor M. Amiji

Mannfred A. Hollinger

University of California, Davis, USA

Northeastern University, Boston, Massachusetts, USA

Presenting general concepts and specific explanations, the third edition of Introduction to Pharmacology provides updated information on a range of subjects related to pharmacology. The text features a new chapter on smooth muscle pharmacology that covers gastrointestinal and pulmonary pharmacology. Additional new topics include nutraceuticals, HIV therapy, humoral medicine, diabetes, the toxicity of vitamin E, the role of biodiversity in drug development, glucocorticoid signaling, cytokines as therapeutics and targets, ligand-selective receptor confirmations, pharmacogenetics, and much more. Self-study questions are also provided at the end of each chapter for students.

Among the various approaches considered, nanotechnology offers the best promise for the targeted delivery of drugs and genes to a tumor site and for alleviating side effects of chemotherapeutic agents. Encouraging communication between clinical investigators and nanoscientists, Nanotechnology for Cancer Therapy focuses specifically on effective and promising nanoscience and nanotechnology strategies for imaging and treating cancer. Renowned industrial and academic researchers describe the advantages of nanoparticles as sensing, delivery, image enhancement agents for cancer treatments, and they also explore various types of useful nanoparticles such as polymeric nanoparticles and dendrimers.

Catalog no. 47418, ISBN: 978-1-4200-4741-7 2008, 7 x 10, 464 pp., Soft Cover Suggested Price: $69.95 / £40.99

Catalog no. 7194, ISBN: 978-0-8493-7194-3 2007, 7 x 10, 840 pp. Suggested Price: $195.95 / £109.00

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For more information and a complete list Pharmacokinetic and Pharmacodynamic Data Analysis Concepts and Applications, Fourth Edition Johan Gabrielsson

Swedish Pharmaceutical Press, Stockholm

Dan Weiner

Principles and Methods of Toxicology Fifth Edition Edited by

A. Wallace Hayes

Pharmacology

West Virginia University, Morgantown, USA

Harvard School of Public Health, Andover, Massachusetts, USA

According to a review in the European Journal of Pharmaceutical Science, this book “raises the stature of PK/PD modeling to its highest level.” This essential professional resource is regarded as the most comprehensive and practical guide to the design, analysis, and interpretation of kinetic and dynamic experiments. It provides the expertise needed to resolve commonly appearing problems with a pedagogic yet accessible approach. For many years a staple in both undergraduate and graduate classrooms, this updated edition adds new case studies to support basic concepts in PK/PD. This edition includes a CD-ROM with exercises and WinNonlin model/ command files.

Extensively revised and updated with four new chapters and several new authors, this fifth edition of a classic text provides comprehensive coverage in a manageable and accessible format. New topics include toxicopanomics, plant and animal poisons, information resources, and non-animal testing alternatives. The book reviews toxicology history and discusses basic toxicological principles, agents that cause toxicity, target organ toxicity, and toxicological testing methods, including many of the test protocols required to meet regulatory needs worldwide. The book examines each procedure and interpretation of data and discusses problems and pitfalls that may be associated with each method.

Catalog no. SP5100, ISBN: 978-9-19-765100-4 2008, 1250 pp. Suggested Price: $209.95 / £117.00

Catalog no. 3778, ISBN: 978-0-8493-3778-9 2008, 8-1/2 x 11, 2296 pp. Suggested Price: $199.95 / £100.00

Seafood and Freshwater Toxins 112

Polymers in Drug Delivery

Pharmacology, Physiology, and Detection, Second Edition

Edited by

Ijeoma F. Uchegbu

Luis M. Botana

University of London, UK

Andreas G. Schatzlein

University of Santiago de Compostela, Lugo, Spain

University of Glasgow, Scotland

Series: Food Science and Technology, 103

In recent years there has been an explosion in the use of polymers to solve various biomedical problems. Polymers play a crucial role in controlling drug release rate, enhancing drug solubility and uptake, and limiting drug degradation and toxicity. Polymers in Drug Delivery is a state-of-the-art documentation and review of all areas in which polymers are used in drug delivery, including hydrogels, soluble polymer drug conjugates, polymeric vesicles and micelles, microspheres, nanoparticles, polymeric in tissue engineering, and more. It is a readily accessible volume suitable for drug delivery scientists and as reading for advanced pharmaceutical students and others new to the field.

This second edition provides an overview of the expanding scope of the field from several perspectives. Incorporating pharmacology, toxicology, chemistry, ecology, and economics, it covers several categories of toxins by function and biomechanism, potential pharmacological applications, and legal and economic perspectives. New toxins are described by their chemical structure, ecobiology, metabolism, detection methods, determination, and pharmacology. Logically organized for clear understanding, this edition includes more information on biological aspects, the effects and actions of each toxin with emphasis on human response, detection and analysis, and food safety issues.

Catalog no. TF4008, ISBN: 978-0-8493-2533-5 2006, 7 x 10, 280 pp. Suggested Price: $164.95 / £92.00

Catalog no. 7437, ISBN: 978-0-8493-7437-1 2008, 7 x 10, 960 pp. Suggested Price: $229.95 / £128.00

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Drug Delivery and Targeting Textbook of Receptor Pharmacology Third Edition

For Pharmacists and Pharmaceutical Scientists Edited by

Anya M. Hillery

Edited by

Saint Louis University, Madrid, Spain

John C. Foreman and Alasdair J. Gibb

Andrew W. Lloyd

Torben Johansen

James Swarbrick

Providing an introduction to the study of drug receptors, the Textbook of Receptor Pharmacology discusses quantitative descriptions of functional studies with agonists and antagonists; quantitative descriptions of ligands binding to receptors; the molecular structures of drug receptors; and the elements that transport the signal from the activated receptor to the intracellular compartment. This third edition features results from recent research on how the structure of receptors determines the interaction between the receptor and the signal transducer. This volume also offers new information on ligand binding receptor studies that use newly developed techniques.

Recent advances in biotechnology and molecular biology have resulted in the discovery of a large number of novel molecules with the potential to revolutionize the treatment and prevention of disease. However, such potential is severely compromised by significant obstacles to delivery of these drugs in vivo. An accessible and easy-to-read text, this is the first book to provide a comprehensive introduction to the principles of advanced drug delivery and targeting, examining current applications and potential future developments. It covers how to optimize therapeutic efficacy; drug absorption, attempts to minimize toxicity or alter immunogenicity; and more.

Catalog no. 52543, ISBN: 978-1-4200-5254-1 June 2009, 7 x 10, 320 pp. Suggested Price: $109.95 / £66.99

Catalog no. TF1359, ISBN: 978-0-415-27198-1 2002, 7 x 10, 496 pp., Soft Cover Suggested Price: $88.95 / £49.99

University of Southern Denmark, Odense

University of Brighton, United Kingdom PharmaceuTech, Inc, Pinehurst, North Carolina, USA

Pharmacology / Pharmacy

University College London, UK

Textbook

Treatments from Toxins

The Therapeutic Potential of Clostridial Neurotoxins

Essentials of Human Physiology for Pharmacy

Edited by

Second Edition

Keith A. Foster, Peter Hambleton, and Clifford C. Shone

Bunker Hill Community College, Boston, Massachusetts, USA

Syntaxin Ltd., Health Protection Agency, Wiltshire, UK

113

Laurie Kelly McCorry

Plant Engineering Series, 19

The recent, rapid developments in the understanding of clostridial toxins have opened the door to therapeutic uses of and treatments against these potent neurotoxins. Researchers have uncovered applications leading to targeted drug delivery agents for the nervous system, as well as for treatments for focal dystonias, spastic paralysis in children with cerebral palsy, and pain relief. Many clinicians, however, are using preparations without awareness of available information that could improve current usage. This book integrates the most recent scientific and clinical information from international authorities covering structure and mechanisms of action for current and emerging applications.

Designed as a resource for pharmacy and health science students, Essentials of Human Physiology for Pharmacy, Second Edition emphasizes the connection and relevance of physiology to pharmacy practice. Every chapter is updated and expanded and new chapters are included on the immune system and the reproductive system. Revised pharmacy applications demonstrate basic principles in physiology and their use in pharmacy practice. Each chapter also offers medical terminology, including definitions, associated terms, and pronunciations, as well as relevant drugs used to treat the disorders discussed, explaining their classifications and therapeutic actions.

Catalog no. 2709, ISBN: 978-0-8493-2709-4 2007, 6-1/8 x 9-1/4, 312 pp. Suggested Price: $209.95 / £117.00

Catalog no. 43900, ISBN: 978-1-4200-4390-7 January 2009, 6-1/8 x 9-1/4, 520 pp. Suggested Price: $79.95 / £44.99

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For more information and a complete list Textbook

Essentials of Law and Ethics for Pharmacy Technicians Second Edition

Kenneth M. Strandberg

Textbook

Pharmaceutical Dosage Forms and Drug Delivery Ram I. Mahato

Pharmacy

North Dakota State University, Fargo, USA

University of Tennessee Health Science Center, Memphis, USA

Plant Engineering Series, 12

Plant Engineering Series

Unique in its focus and coverage, the updated edition of Essentials of Law and Ethics for Pharmacy Technicians clearly explains those laws and regulations relevant to technicians and also examines the ethical issues involved. Fully revised to cover recent developments, it presents an overview of the US legal system, reviews the development of current laws, and describes those laws affecting practice today. It incorporates a new chapter on the Health Information Portability and Accountability Act, the Dietary Supplement Health and Education Act, and the new FDA regulation on controlling pseudoephedrine sales. State issues are addressed in the extensive appendices.

Integrating aspects of physical pharmacy, biopharmaceuticals, drug delivery, and biotechnology, Pharmaceutical Dosage Forms and Drug Delivery presents basic physico-chemical principles and their application in the design of dosage forms. This book addresses the relevance of these principles to the biopharmaceutical aspects of drugs. It explores the latest developments in the application of biomaterials, including polymers and biotechnology-based agents, to the development of novel dosage forms. In addition, the book discusses physico-chemical parameters used for the design, development, and evaluation of biotechnological dosage forms. This text also provides review questions and answers for students.

Catalog no. 45563, ISBN: 978-1-4200-4556-7 2007, 6-1/8 x 9-1/4, 208 pp., Soft Cover Suggested Price: $49.95 / £29.99

Managing Pharmacy Practice

114 Principles, Strategies, and

Catalog no. 9285, ISBN: 978-0-8493-9285-6 2007, 6-1/8 x 9-1/4, 336 pp. Suggested Price: $83.95 / £46.99

Textbook

Pharmacy

Systems

What It Is and How It Works, Second Edition

Edited by

William N. Kelly

Andrew M. Peterson

Philadelphia College of Pharmacy, Pennsylvania, USA

William N. Kelly Consulting Inc., Oldsmar, Florida, USA Plant Engineering Series, 10

Highlighting the growing impact of technology throughout pharmacy and healthcare, this text underlines the challenges of this rapidly evolving profession and explores strategies for success. Touching on basic management theory and thoroughly discussing systems theory, the text supplies the groundwork for analyzing managerial systems. This systems approach allows readers to understand the contextual relationships between seemingly disparate concepts. With contributions from leaders in fields as diverse as pharmacy, human resources, education, and management, the book presents a broad overview of the complexities and intricacies inherent in managing systems in pharmacy.

The health care and pharmacy environments have changed substantially since the first edition of this book. Developments include the new Medicare prescription benefit, a growing emphasis on medication safety, and the dynamic technology driving safety in organized health care settings. This second edition explores all of these changes that have affected the field of pharmacy in recent years. Expanding coverage throughout, the text features a new chapter on the role of the pharmacist in today’s health care delivery system, as well as new material on support personnel, the consolidation of ambulatory pharmacy, and current controversies within the pharmaceutical industry.

Catalog no. 1446, ISBN: 978-0-8493-1446-9 2004, 536 pp. Suggested Price: $93.95 / £51.99

Catalog no. 7246, ISBN: 978-0-8493-7246-9 2007, 6-1/8 x 9-1/4, 512 pp. Suggested Price: $55.95 / £30.99

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

A Management Systems Approach

Bioinformatics

A Practical Approach Shui Qing Ye

University of Missouri, Columbia, USA

Charles D. Hepler and Richard Segal University of Florida, Gainesville, Florida, USA

Series: Chapman & Hall/CRC Mathematical & Computational Biology

Every year, drug-related illnesses and complications cost the American healthcare system billions of dollars, while medical errors, the majority of which are related to drugs, account for approximately 100,000 deaths. Synthesizing research studies from seven nations, Preventing Medication Errors and Improving Drug Therapy Outcomes identifies pharmacists as a strategic resource in solving the problem of preventable adverse outcomes from drug therapy. This important resource explores the safety, cost-effectiveness, and quality of medications use from a management systems perspective, and proposes systematic solutions to the unnecessary risks that accompany drug therapy.

This practical book presents the most state-of-the-art bioinformatics applications. It first focuses on genome analysis, common DNA analysis tools, phylogenetics analysis, and SNP and haplotype analysis. Following chapters on microarray, SAGE, regulation of gene expression, miRNA, and siRNA, the book presents widely applied programs and tools in proteome analysis, protein sequences, protein functions, and functional annotation of proteins in murine models. With more than 250 figures to complement the text, the book also introduces the programming languages used in biology, website and database design, and the interchange of data between Microsoft Excel and Access.

Catalog no. 1576, ISBN: 978-0-8493-1576-3 2003, 6-1/8 x 9-1/4, 434 pp. Suggested Price: $185.95 / £103.00

Catalog no. C8105, ISBN: 978-1-58488-810-9 2008, 6-1/8 x 9-1/4, 648 pp. Suggested Price: $83.95 / £46.99

Pharmacy / Bioinformatics

Preventing Medication Errors and Improving Drug Therapy Outcomes

Bioinformatics Basics Applications in Biological Science and Medicine, Second Edition

Textbook

Algorithms in Bioinformatics

Edited by

A Practical Introduction Wing-Kin Sung

Lukas K. Buehler

115

Southwestern College & University of California, San Diego, USA

Hooman H. Rashidi

National University of Singapore Series: Chapman & Hall/CRC Mathematical & Computational Biology

Algorithms in Bioinformatics: A Practical Introduction focuses on using algorithms and discrete mathematics to solve biological problems. This comprehensive volume systematically describes biological applications, the corresponding mathematical and computational problems, and various algorithmic solutions. The author also discusses the practical use of many algorithmic methods and describes which algorithms would best be used in different situations. The text provides references to further reading and a set of knowledge-testing exercises, along with instruction and data for practical exercises which are available on the author’s website. Catalog no. C7033, ISBN: 978-1-4200-7033-0 June 2009, 6-1/8 x 9-1/4, 406 pp. Suggested Price: $79.95 / £39.99

Yale School of Medicine, New Haven, Connecticut, USA

Bioinformatics Basics: Applications in Biological Science and Medicine, Second Edition continues to be an essential tool for researchers who need to easily access and use databases to gather information on genes, proteins, and diseases. This latest edition of a bestseller covers new approaches to data analysis using databases from around the world, identifying computing techniques that help readers manage the massive flow of information. The structure of this second edition follows that of the first and its content reflects the growth in information in recent years. Updated sections cover recent developments in genome projects, microarrays, proteomics, genome mapping, and more. Catalog no. 1283, ISBN: 978-0-8493-1283-0 2005, 6-1/8 x 9-1/4, 360 pp. Suggested Price: $104.95 / £57.99

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For more information and a complete list Biological Data Mining Edited by

Jake Y. Chen

Indiana University-Purdue, Indianapolis, USA

Stefano Lonardi

University of California, Riverside, USA

Bioinformatics 116

Computational Protein-Protein Interactions Ruth Nussinov

National Cancer Institute, Frederick, Maryland, USA

Chapman & Hall/CRC Data Mining and Knowledge Discovery Series

Gideon Schreiber

With techniques spanning the entire spectrum of bioinformatics, this book features the latest data mining and knowledge discovery advances for post-genome biology. It includes computational biology methods, algorithms, and software that can help sequence analysis, protein structure analysis, comparative genomics, functional genomics, statistical genetics, proteomics, network analysis, integrative systems biology, and translational biomedical applications. Containing contributions from leading experts, the book also shows how to use combinations of computational techniques in data mining or related data management and information sciences to solve real biological problems.

A description of fundamental and applied aspects of the usefulness of computations when approaching protein-protein interactions, this book incorporates different views of the same biochemical problem from sequence to structure to energetics. It covers proteinprotein interaction prediction and dynamics, design, drug design for inhibition, and uses for predicting function. The text provides an overview of the topic with general chapters understandable by students and junior researches in this area, while also providing advanced material for more specialized readers. The chapters detail the complexity of protein interaction studies and inform readers of potential caveats that might be involved.

Catalog no. C6847, ISBN: 978-1-4200-8684-3 July 2009, 600 pp. Suggested Price: $99.95 / £60.99

Catalog no. 70053, ISBN: 978-1-4200-7005-7 June 2009, 6-1/8 x 9-1/4, 248 pp. Suggested Price: $99.95 / £60.99

Combinatorial Pattern Matching Algorithms in Computational Biology using Perl and R Gabriel Valiente

Herzel, Israel

Textbook

Data Analysis Tools for DNA Microarrays

Technical University of Catalonia, Barcelona, Spain

Sorin Draghici

Series: Chapman & Hall/CRC Mathematical & Computational Biology

Series: Chapman & Hall/CRC Mathematical & Computational Biology, 4

This book addresses specific pattern matching problems for sequences, tressa, and graphs. It examines specific algorithmic problems that arise when dealing with structures in computational biology, including biology sequences, phylogenetic trees, networks, and metabolic and signaling pathways. For each of these problems, the author offers a clear distinction between problems in the analysis of one structure and in the comparative analysis of two or more structures. He also provides full Perl and R implementation as well as pointers to other software, such as CPAN, Bioperl, CRAN, and Bioconductor. The Perl and R source code are included on the author’s website.

To help meet the challenges of DNA research, Data Analysis Tools for DNA Microarrays builds the foundation in the statistics and data analysis needed by biologists and provides the overview of microarrays needed by computer scientists. It presents the basics of microarray technology and more importantly, the specific problems the technology poses from the data analysis perspective. It also introduces, in simple language, the fundamentals of statistics and the details of the techniques most useful in microarray data analysis. The book is richly illustrated in color and comes with a CD-ROM containing trial software from BioDiscovery and Insightful.

Catalog no. C6973, ISBN: 978-1-4200-6973-0 June 2009, 6-1/8 x 9-1/4, 386 pp. Suggested Price: $89.95 / £54.99

Wayne State University, Detroit, Michigan, USA

Catalog no. C3154, ISBN: 978-1-58488-315-9 2003, 6-1/8 x 9-1/4, 552 pp. Suggested Price: $93.95 / £51.99

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m DNA Methylation Microarrays Sun-Chong Wang

National Central University, Chungli Taoyuan, Taiwan

Arturas Petronis

Functional Informatics in Drug Discovery Edited by

Centre for Addiction and Mental Health, Toronto, Ontario, Canada

Sergey Ilyin

Serigene LLC, Oreland, Pennsylvania, USA

Chapman & Hall/CRC Biostatistics Series

Drug Discovery Series

Illustrating results with examples based on real data, this book presents the statistical methods and tools to analyze DNA methylation microarray data. It describes wet-bench technologies that produce the data for analysis, explains how to preprocess the data to remove systematic artifacts resulting from measurement imperfections, and explores differential methylation and genomic tiling arrays. The authors show how cluster and network analyses can link the functions and roles of unannotated DNA elements with known ones. They also survey the open source software, public databases, and other online resources in microarray research. An accompanying CD-ROM contains files of plots and many color images.

This volume examines the impact of informatics tools on various areas in biopharmaceuticals by presenting in-depth analyses of emerging trends and future opportunities. It presents automation approaches for collecting and analyzing biological data and explains how to use PD biomarkers to accelerate drug development. The book also reviews a variety of novel drug discovery approaches presently used at Johnson & Johnson, and discusses the clinical successes of antibody therapeutics for treating oncology cases. In addition, it offers an integrated approach to identifying relevant target genes for drug discovery and explores the application of laser microdissection in transcriptomics.

Catalog no. C6727, ISBN: 978-1-4200-6727-9 2008, 6-1/8 x 9-1/4, 256 pp. Suggested Price: $79.95 / £44.99

Catalog no. DK3257, ISBN: 978-1-57444-466-7 2008, 6-1/8 x 9-1/4, 160 pp. Suggested Price: $104.95 / £57.99

DNA Microarrays and Related Genomics Techniques

Textbook

Edited by

Basic Concepts, Algorithms, and Applications

Design, Analysis, and Interpretation of Experiments

David B. Allison, Grier P. Page, T. Mark Beasley, and Jode W. Edwards University of Alabama, Birmingham, USA

Chapman & Hall/CRC Biostatistics Series, 15

With contributions from distinguished experts in the field, DNA Microarrays and Related Genomics Techniques parallels the steps in conducting and analyzing a microarray experiment from conception to interpretation. This book explores critical aspects of designing a microarray experiment, including power and sample size. It assesses the validity of statistical methods and describes how to ensure the quality and integrity of data. In addition, the text discusses new methods for interpreting microarray data and examines the various issues associated with analysis. It also addresses the movement to make large high-dimensional datasets public for further analysis, and describes the associated methods. Catalog no. DK2187, ISBN: 978-0-8247-5461-7 2006, 6-1/8 x 9-1/4, 392 pp. Suggested Price: $93.95 / £51.99

Bioinformatics

Experimental Design and Statistical Analysis

Fundamentals of Natural Computing

117

Leandro Nunes de Castro

Catholic University of Santos, Brazil Chapman & Hall/CRC Computer & Information Science Series, 11

A wide-ranging survey of novel techniques and important applications, this book contains theoretical and philosophical discussions, pseudocodes for algorithms, and computing paradigms that illustrate how computational techniques can solve complex problems, simulate nature, explain natural phenomena, and allow the development of new computing technologies. The author uses a consistent and approachable format that includes figures, tables, examples, and exercises that encourage readers to apply the computational tools. Topics include evolutionary computing, neurocomputing, swarm intelligence, immunocomputing, fractal geometry, artificial life, quantum computing, and DNA computing. Catalog no. C6439, ISBN: 978-1-58488-643-3 2006, 6-1/8 x 9-1/4, 696 pp. Suggested Price: $89.95 / £45.99

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For more information and a complete list Textbook

Fundamentals of Statistical Bioinformatics

Edited by

Sunil Mathur

Srinivas Aluru

Statistics: A Series of Textbooks and Monographs

Chapman & Hall/CRC Computer & Information Science Series, 9

Fundamentals of Statistical Bioinformatics provides an understanding of biological mechanisms and presents the most current techniques to analyze data obtained through different technologies. This book offers the foundations of mathematics, statistics, biology, and computer science needed to understand the methods presented in the text. Developing concepts from the introductory to the advanced level, the text provides detailed coverage of modern analytical techniques such as Markov chain Monte Carlo (MCMC) and Bayesian methods. It also addresses useful web-based tools like CDART and provides a working knowledge of the R language and the codes available for analyzing sequences.

The Handbook of Computational Molecular Biology offers a comprehensive, systematic treatment of computational biology, from the most basic concepts to advanced applications. Algorithmic in nature, the handbook highlights applications to molecular biology through every topic covered. In addition, many of the newer topics in the field are covered in depth, such as microarrays, comparative genomics and external memory algorithms, and parallel methods. Written by experts in the field, it covers problems related to understanding genetic diseases, the design of drugs tailored to the individual, deciphering the genomes of specific organisms, and understanding the process of evolution.

Catalog no. C6552, ISBN: 978-1-58488-655-6 June 2009, 6 x 9, 400 pp. Suggested Price: $89.95 / £54.99

Catalog no. C061, ISBN: 978-1-58488-406-4 2006, 7 x 10, 1104 pp. Suggested Price: $144.95 / £79.99

Gene Expression Studies Using Affymetrix Microarrays

Handbook of Hidden Markov Models in Bioinformatics

University of Mississippi, University, USA

Bioinformatics 118

Handbook of Computational Molecular Biology

Hinrich Gohlmann and Willem Talloen

Iowa State University, Ames, USA

Martin Gollery

Johnson & Johnson, Beerse, Belgium

Martin is Senior Bioinformatics Scientist at Active Motif.

Series: Chapman & Hall/CRC Mathematical & Computational Biology

Gene Expression Studies Using Affymetrix Microarrays tears down the omnipresent language barriers among molecular biology, bioinformatics, and biostatistics researchers by explaining the entire process of a gene expression study from conception to interpretation. It covers important technical and statistical pitfalls and problems, helping not only to explain concepts outside the domain of researchers, but to provide additional guidance in their field of expertise. The book also describes technical and statistical methods conceptually with illustrative examples, enabling those inexperienced with gene expression studies to grasp the basic principles.

Demonstrating that many useful resources, such as databases, can benefit most bioinformatics projects, this handbook focuses on how to choose and use various methods and programs available for HMMs. It explores HMM implementations important in bioinformatics, including SAM, HMMER, Wise2, PSI-BLAST, and Meta-MEME, and shows how numerous databases and programs, such as Pfam, SMART, SUPERFAMILY, and PANTHER, are used in bioinformatics projects. With the inclusion of problems sets in each chapter and a CD-ROM of related material, the book discusses the use of HMMs for discovering the homology of a protein family, explains how to build custom HMM databases, and offers solutions to help overcome slow searches.

Catalog no. C6515, ISBN: 978-1-4200-6515-2 June 2009, 6-1/8 x 9-1/4, 440 pp. Suggested Price: $89.95 / £54.99

Catalog no. C6846, ISBN: 978-1-58488-684-6 2008, 6-1/8 x 9-1/4, 176 pp. Suggested Price: $59.95 / £33.99

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Textbook

An Introduction to Systems Biology

Textbook

Introduction to Bioinformatics Anna Tramontano

Uri Alon

University of Rome La Sapienza, Italy

Harvard Medical School, Boston MA, USA

Series: Chapman & Hall/CRC Mathematical & Computational Biology, 13

Series: Chapman & Hall/CRC Mathematical & Computational Biology, 10

From the elucidation and analysis of a genomic sequence to the prediction of a protein structure and the identification of the molecular function, Introduction to Bioinformatics describes the rationale and limitations of the bioinformatics methods and tools that can help solve biological problems. The author addresses the ways to store and retrieve biological data, decrypt information encoded by genomes, and detect and exploit the evolutionary and functional relationships among biological elements. The book also includes material on proteomics that is not found in any other basic bioinformatics textbook. It concludes with a discussion of the future of bioinformatics.

This book presents recently discovered design principles that govern the structure and behavior of biological networks such as gene circuits, highlighting simple, recurring circuit elements that make up the network. It provides a quantitative theory for which circuits are found in a given environment and a mathematical framework for understanding and even designing biological circuits. The book requires only basic mathematics understanding and includes a review of the necessary background material. It fills a significant need for a textbook and introduction to the concepts, principles, and mathematical tools that will form the basis of future developments in the field.

Catalog no. C5696, ISBN: 978-1-58488-569-6 2007, 6-1/8 x 9-1/4, 192 pp., Soft Cover Suggested Price: $62.95 / £34.99

Catalog no. C6420, ISBN: 978-1-58488-642-6 2007, 7 x 10, 320 pp., Soft Cover Suggested Price: $57.95 / £31.99

Bioinformatics

Design Principles of Biological Circuits

Textbook

Introduction to Machine Learning and Bioinformatics Sushmita Mitra, Sujay Datta, Theodore Perkins, and George Michailidis

Kinetic Modelling in Systems Biology 119

Oleg Demin

Moscow State University, Russia

Igor Goryanin

University of Edinburgh, Scotland, UK

Series: Chapman & Hall/CRC Computer Science & Data Analysis

Series: Chapman & Hall/CRC Mathematical & Computational Biology, 19

Examining the connections between these two increasingly intertwined areas, this text presents a unifying, thorough, and accessible introduction to the basic ideas and latest developments in machine learning and bioinformatics. It describes the major problems in bioinformatics and the concepts and algorithms of machine learning. The authors demonstrate the capabilities of key machine learning techniques, such as hidden Markov models and artificial neural networks, and apply state-of-the-art techniques to bioinformatics problems in structural biology, cancer treatment, and proteomics. They also include exercises at the end of some chapters and offer instructional materials on their website.

Focusing on one of the main pillars in the future development of systems biology, this book explores the kinetic modeling approach and how to apply it to solve real-life problems. It covers model creation techniques, model verification and validation, and simulations and interpretation of biological results. The authors describe underlying algorithms for selected reference methods and present several examples of applications, ranging from drug safety mechanisms to multiple target identification analysis to optimization of E. coli amino acid biosynthesis. The accompanying CD-ROM contains pathway diagrams, model examples, EPE software, and DBSolve installation.

Catalog no. C682X, ISBN: 978-1-58488-682-2 2008, 6-1/8 x 9-1/4, 384 pp. Suggested Price: $79.95 / £39.99

Catalog no. C6676, ISBN: 978-1-58488-667-9 January 2009, 6-1/8 x 9-1/4, 360 pp. Suggested Price: $79.95 / £44.99

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For more information and a complete list Meta-analysis and Combining Information in Genetics and Genomics Edited by

Pattern Discovery in Bioinformatics Theory & Algorithms

Rudy Guerra

Rice University, Houston, Texas, USA

Laxmi Parida

David B. Allison

IBM TJ Watson Research Center, Yorktown Heights, New York, USA

Darlene Goldstein

EPFL SB IMA STAT, Switzerland

Series: Chapman & Hall/CRC Mathematical & Computational Biology

With contributions from leading experts, Meta-analysis and Combining Information in Genetics and Genomics provides theory, methods, and guiding principles for meta-analysis and combining information for various types of genetic studies. The book begins with an introduction to meta-analysis and combining information as well as statistical genetics, bioinformatics, and proteomics. Addressing the complications inherent in comparing and replicating genetic studies, the contributors carefully examine microarrays, gene mapping, and proteomics. They detail the various techniques used to analyze and combine data from different types of studies. This is the first book devoted to meta-analysis in genetics.

Taking a systematic approach to pattern discovery, this self-contained book supplies sound mathematical definitions and efficient algorithms to explain vital information about biological data. A solid foundation in computational methods, it explores various data patterns, including strings, clusters, permutations, topology, partial orders, and boolean expressions, to capture a different form of regularity in the data. The book focuses on models of biological sequences, including DNA, RNA, and protein sequences. With numerous exercises at the end of each chapter, it also reviews basic statistics, including probability, information theory, and the central limit theorem.

Catalog no. C522X, ISBN: 978-1-58488-522-1 May 2009, 6-1/8 x 9-1/4, 406 pp. Suggested Price: $99.95 / £60.99

Catalog no. C5491, ISBN: 978-1-58488-549-8 2008, 6-1/8 x 9-1/4, 512 pp. Suggested Price: $83.95 / £46.99

University of Alabama at Birmingham, USA

Bioinformatics

Microarray Innovations

Technology and 120 Experimentation Edited by

Protein Engineering and Design

Gary Hardiman

Sheldon J. Park

University of California at San Diego, La Jolla, USA Drug Discovery Series, 11

State University of New York at Buffalo, USA

Jennifer R. Cochran

Stanford University, California, USA

Microarray technologies and applications have evolved steadily with increasing content and better analytical methodologies. This compendium represents a cross section of the past five years of microarray methods and applications and their usage in drug discovery and biomedical research. Expert contributors cover improvements in automation, new substrates for printing arrays, platform comparisons and contrasts, experimental design, data normalization and mining schemes, epigenomic array studies, electronic microarrays, comparative genomic hybridization, microRNA arrays, mutational analyses, clinical diagnostic arrays, protein arrays and neuroscience applications.

The cutting-edge development of using a computational design approach as a means of engineering proteins with novel functions has led to widespread usage of computational analysis in protein engineering. However, because the structure and function of protein molecules are coupled at the molecular level, many critical questions are left unanswered and many of the intricate design rules unclear. This book furthers understanding in this complex area by using lucid description of computation’s role in protein engineering and tracing the history of protein design. It successfully de-mystifies computational analysis, thereby making it widely accessible to a broad audience both in academia and industry.

Catalog no. 94483, ISBN: 978-1-4200-9448-0 March 2009, 6-1/8 x 9-1/4, 336 pp. Suggested Price: $129.95 / £78.99

Catalog no. 76582, ISBN: 978-1-4200-7658-5 June 2009, 6-1/8 x 9-1/4, 248 pp. Suggested Price: $119.95 / £72.99

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Statistical and Computational Pharmacogenomics

Python for Bioinformatics

Rongling Wu

University of Florida, Gainesville, USA

Universidad Nacional de Quilmes, Bernal, Argentina Series: Chapman & Hall/CRC Mathematical & Computational Biology

Min Lin

Duke Clinical Research Institute, Durham, North Carolina, USA Series: Interdisciplinary Statistics

Python is a popular computer language used in a wide range of applications, from peer-to-peer software to dynamic generated web pages. Python for Bioinformatics provides an accessible introduction to both the Python and BioPython languages. The book addresses advanced topics, from web applications and XML to databases and version control. In addition to useful appendices with reference material on biological file formats, the book presents commented working code and new programming techniques, such as error handling, functions, and modules. It also includes source code as well as a companion CD-ROM that contains a virtual machine with complete installation and a working web server.

Due to the tremendous accumulation of data for genetic markers, pharmacogenomics, the study of the functions and interactions of all genes in the overall variability of drug response, is one of the hottest areas of research in biomedical science. Statistical and Computational Pharmacogenomics presents recent developments in statistical methodology with a number of detailed worked examples that outline how these methods can be applied. This comprehensive volume provides key tools needed to understand and model the genetic variation for drug response and equips statisticians with a thorough understanding of this complex field and how computational skills can be employed.

Catalog no. C9292, ISBN: 978-1-58488-929-8 May 2009, 6-1/8 x 9-1/4, 456 pp., Soft Cover Suggested Price: $59.95 / £36.99

Catalog no. C8288, ISBN: 978-1-58488-828-4 January 2009, 6-1/8 x 9-1/4, 368 pp. Suggested Price: $79.95 / £44.99

Bioinformatics

Sebastian Bassi

Textbook

R Programming for Bioinformatics Robert Gentleman

Statistics in Human Genetics and Molecular Biology

121

Fred Hutchinson Cancer Research Center, Washington, USA

Cavan Reilly

Series: Chapman & Hall/CRC Computer Science & Data Analysis

Chapman & Hall/CRC Texts in Statistical Science Series

Drawing on the author’s first-hand experiences as an expert in R, this practical guide focuses on the programming skills needed to use R for the solution of bioinformatics and computational biology problems. It covers the fundamentals of the R language, objectoriented programming in R, and data mark-up and web services languages and tools. The author also examines different aspects of string handling and manipulations; discusses the interfacing of R with other languages, such as C, FORTRAN, Perl, and Python; and explains how to write software packages as well as debug and profile R code. The complete source code is available on the book’s website.

Focusing on problems in contemporary genetics and molecular biology, this text describes basic statistical methods used in genetics. It covers cluster analysis, combinatorial optimization, and dynamic programming, along with the core topics of genome mapping, biological sequence analysis, and the analysis of gene expression arrays. The author also explores Bayesian approaches, such as hidden Markov models and block motif methods, as well as modern tools of Bayesian analysis, including Markov chain Monte Carlo (MCMC). The text features a number of worked examples and problem sets at the end of each chapter.

Catalog no. C6367, ISBN: 978-1-4200-6367-7 January 2009, 6-1/8 x 9-1/4, 328 pp. Suggested Price: $69.95 / £38.99

University of Minnesota, Minneapolis, USA

Catalog no. C7263, ISBN: 978-1-4200-7263-1 June 2009, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $59.95 / £36.99

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For more information and a complete list

Textbook

Stochastic Modelling for Systems Biology Darren J. Wilkinson Newcastle University, UK

Textbook

Systems Biology and Bioinformatics

A Computational Approach

Bioinformatics

Series: Chapman & Hall/CRC Mathematical & Computational Biology, 11

Kayvan Najarian

Although stochastic kinetic models are increasingly accepted as the best way to represent and simulate genetic and biochemical networks, most researchers in the field have limited knowledge of stochastic process theory. Stochastic Modelling for Systems Biology provides an accessible introduction to this theory using examples that are familiar to systems biology researchers. Focusing on computer simulation, the author examines the use of stochastic processes for modelling biological systems. Along with the latest simulation techniques and research material, such as parameter inference, the text includes many examples and figures as well as software code in R for various applications.

Emphasizing computational methods, Systems Biology and Bioinformatics provides an introduction to systems biology and its impact on biology and medicine. The book reviews the basic principles of molecular and cell biology using a system-oriented approach, with a brief description of the high-throughput biological experiments that produce databases. The methods presented in the text include techniques to discover genes, perform nucleotide and amino acid sequence matching, and estimate static gene dynamic pathways. The book also explains how to use system-oriented models to predict the behavior of biological systems for important applications such as rational drug design.

Catalog no. C5408, ISBN: 978-1-58488-540-5 2006, 6-1/8 x 9-1/4, 280 pp. Suggested Price: $88.95 / £49.99

Catalog no. 46500, ISBN: 978-1-4200-4650-2 April 2009, 6-1/8 x 9-1/4, 208 pp. Suggested Price: $89.95 / £48.99

University of North Carolina, Charlotte, USA

Textbook

122

Structural Bioinformatics

Systems Biology

An Algorithmic Approach

Principles, Methods, and Concepts

Forbes J. Burkowski

Edited by

University of Waterloo, Ontario, Canada Series: Chapman & Hall/CRC Mathematical & Computational Biology, 20

Showcasing the beauty of protein structures, this practical text illustrates how to apply key algorithms to solve problems related to macromolecular structure. It emphasizes a methodology that uses mathematical models to act as links between structural biology and computational algorithms. The author shows that protein structure can produce symmetry and beauty as well as biological function. He also gives many examples of dynamic programming applications, including RNA secondary structure prediction and protein sequence alignment. The text includes problems throughout, exercises at the end of each chapter, and a 12-page color insert. Catalog no. C6838, ISBN: 978-1-58488-683-9 January 2009, 6-1/8 x 9-1/4, 429 pp. Suggested Price: $79.95 / £44.99

A.K. Konopka

BioLingua Research, Inc., Gaithersburg, Maryland, USA

With extraordinary clarity, Systems Biology: Principles, Methods, and Concepts focuses on the technical, practical aspects of modeling complex or organic general systems. It also provides in-depth coverage of modeling biochemical, thermodynamic, engineering, and ecological systems. Among other methods and concepts based in logic, computer science, and dynamical systems, it explores pragmatic techniques of general systems theory. This text presents biology as an autonomous science from the perspective of fundamental modeling techniques. A complete resource for anyone interested in biology as an exact science, it includes a comprehensive review of concepts and methods in systems biology. Catalog no. DK3072, ISBN: 978-0-8247-2520-4 2007, 7 x 10, 256 pp. Suggested Price: $73.95 / £40.99

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

Mark Chang

A Practical Guide

AMAG Pharmaceuticals, Inc, Lexington, Massachusetts, USA

Hugh Cartwright Oxford University, UK

Chapman & Hall/CRC Biostatistics Series

In a lucid, straightforward manner, this book explains how Artificial Intelligence (AI) methods are used by scientists and what can be accomplished with them. Designed for those with no prior programming knowledge, this book efficiently and quickly teaches meaningful scientific applications. Using a practical and direct approach, it addresses the needs of scientists across a range of disciplines. Topics include an introduction to artificial intelligence, artificial neural networks, self-organizing maps, growing cell structures, evolutionary algorithms, cellular automata, expert systems, fuzzy logic, learning classifier systems, and evolvable developmental systems.

This book provides a concise, unified presentation of adaptive design theories, uses SAS and R for the design and simulation of adaptive trials, and illustrates how to master different adaptive designs through real-world examples. It emphasizes the relationships among different methods; presents current regulatory views; discusses the challenges in planning, executing, analyzing, and reporting adaptive designs; and features Bayesian decision theory to optimize adaptive designs and programs. The author also explores controversial issues surrounding statistical theories as well as fruitful avenues for future research and applications of adaptive designs.

Catalog no. 8412, ISBN: 978-0-8493-8412-7 2008, 6-1/8 x 9-1/4, 360 pp. Suggested Price: $129.95 / £72.99

Adaptive Design Methods in Clinical Trials Shein-Chung Chow

Duke University School of Medicine, Durham, North Carolina, USA

Mark Chang

Catalog no. C962X, ISBN: 978-1-58488-962-5 2007, 6-1/8 x 9-1/4, 440 pp. Suggested Price: $89.95 / £48.99

Bioinformatics / Biostatistics

Adaptive Design Theory and Implementation Using SAS and R

Using Artificial Intelligence in Chemistry and Biology

Textbook

Basic Statistics and Pharmaceutical Statistical Applications

123

Second Edition

AMAG Pharmaceuticals, Inc, Lexington, Massachusetts, USA

James E. DeMuth

Chapman & Hall/CRC Biostatistics Series, 17

Chapman & Hall/CRC Biostatistics Series

One of the first books on the topic, Adaptive Design Methods in Clinical Trials presents the principles and methodologies in adaptive design and analysis that pertain to adaptations made to trial or statistical procedures based on accrued data of ongoing clinical trials. The book also offers a well-balanced summary of current regulatory perspectives, recently developed statistical methods, and practical guidelines for choosing an optimal design. Providing a broad range of adaptive design methods that use both analytical and simulation approaches, this resource fills the need for a unified, comprehensive, and updated book in the clinical research and development of adaptive design and analysis.

Focusing on applications to research, clinical trials, and quality control, Basic Statistics and Pharmaceutical Statistical Applications is a practical, easy-to-use text and reference that builds a basic knowledge of statistics. Accessible and non-threatening, it discusses all of the commonly used statistical tests and presents them with examples and worked out results. The emphasis is on correctly interpreting research results rather than on theory. Thoroughly revised and expanded, this edition includes new chapters on measures of associations, odds and relative risks ratios, and survival statistics. Other new material addresses process capability, tolerance limits, and reproducibility.

Catalog no. C7761, ISBN: 978-1-58488-776-8 2007, 6 x 9, 296 pp. Suggested Price: $89.95 / £49.99

Catalog no. DK799X, ISBN: 978-0-8493-3799-4 2006, 6-1/8 x 9-1/4, 744 pp. Suggested Price: $89.95 / £39.99

University of Wisconsin - Madison, USA

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For more information and a complete list Clinical Trials in Oncology Second Edition Stephanie Green

Pfizer, Inc., New London, Connecticut, USA

Bayesian Biostatistics and Diagnostic Medicine Lyle D. Broemeling

Medical Lake, Washington, USA

Biostatistics

Exploring Bayesian statistics at an introductory level, this book illustrates how to apply these methods to solve important problems in medicine and biology. After focusing on the wide range of areas where diagnostic medicine is used, the book introduces Bayesian statistics and the estimation of accuracy. The author then discusses patient covariate information and the statistical methods for estimating the agreement among observers. The book also explains the protocol review process for cancer clinical trials, how tumor responses are categorized, how to use WHO and RECIST criteria, and how Bayesian sequential methods are employed to monitor trials and estimate sample sizes. Catalog no. C7672, ISBN: 978-1-58488-767-6 2008, 6-1/8 x 9-1/4, 216 pp. Suggested Price: $83.95 / £42.99

Bayesian Disease Mapping

124 Hierarchical Modeling in

Spatial Epidemiology Andrew Lawson

Jacqueline Benedetti

Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

John Crowley

Cancer Research & Biostatistics, Seattle, Washington, USA Series: Interdisciplinary Statistics, 10

The latest edition of the best-selling Clinical Trials in Oncology provides a concise, nontechnical, and thoroughly up-to-date review of methods and issues related to clinical trials. The authors emphasize the importance of proper study design, analysis, and data management and identify the pitfalls inherent in these processes. This edition includes a section covering innovations in Phase I designs and another on overcoming the challenges of array data. As always, the authors use clear, lucid prose and a multitude of real-world trials as examples to convey the principles of successful trials without the need for readers to have a strong statistics or mathematics background. Catalog no. C3022, ISBN: 978-1-58488-302-9 2003, 6-1/8 x 9-1/4, 280 pp. Suggested Price: $104.95 / £57.99

Cluster Randomised Trials A Practical Approach Richard J. Hayes

London School of Hygiene & Tropical Medicine, London, UK

Lawrence H. Moulton

University of South Carolina, Columbia, USA

Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

Series: Interdisciplinary Statistics

This work provides an overview of the main areas of Bayesian hierarchical modeling and its application to the geographical analysis of disease. It explores a range of topics in Bayesian inference and modeling, including Markov chain Monte Carlo methods, Gibbs sampling, the Metropolis–Hastings algorithm, goodness-offit measures, and residual diagnostics. The author explains how to apply these methods to disease mapping using numerous real-world data sets pertaining to cancer, asthma, epilepsy, foot and mouth disease, influenza, and other afflictions. Data sets, WinBUGS ODC files, and R code are available on the author’s website.

There is an increasing need for new health interventions to be rigorously evaluated through randomized controlled trials, which have become the gold standard for intervention studies. In addition, there is increasing acceptance of cluster randomized trials (CRTs) as the most appropriate choice of study design. Cluster Randomised Trials covers the design, analysis, and conduct of health intervention trials in which groups or clusters of individuals are randomized to different conditions. With an emphasis on key concepts rather than mathematical details, the book uses case studies to illustrate methods and Stata code based on real-world datasets to demonstrate analytical methods.

Catalog no. C8407, ISBN: 978-1-58488-840-6 January 2009, 6-1/8 x 9-1/4, 368 pp. Suggested Price: $79.95 / £44.99

Catalog no. C8164, ISBN: 978-1-58488-816-1 January 2009, 6-1/8 x 9-1/4, 338 pp. Suggested Price: $89.95 / £54.99

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

Oakland University, Rochester, Michigan, USA

Data and Safety Monitoring Committees in Clinical Trials

Dayanand N. Naik

Jay Herson

Edited by

Ravindra Khattree

Old Dominion University, Norfolk, Virginia, USA

Johns Hopkins University, Baltimore, Maryland, USA

Chapman & Hall/CRC Biostatistics Series

Using real-world data from disease areas such as cancer and HIV, this volume explores important computational statistical methods that are employed in biomedical research. It discusses microarray data analysis, machine learning techniques, and mass spectrometrybased protein profiling. The book also uses state space models to predict US cancer mortality rates and describes the application of multistate models to analyze multiple failure times. It covers various Bayesian techniques, the sequential monitoring of randomization tests, mixed-effects models, classification rules for repeated measures data, and estimation methods for analyzing longitudinal data.

Focusing on the practical clinical and statistical issues that arise in pharmaceutical industry trials, this book summarizes the author’s experience in serving on many DMCs and in heading up a contract research organization that provided statistical support to nearly seventy-five DMCs. It explains the difference in DMC operations between the pharmaceutical industry and NIH-sponsored trials. Leading readers through the types of reports for adverse events and lab values, the author presents the statistical requirements of data monitoring committees and gives advice on how statisticians can best interact with physician members of these committees.

Catalog no. C5777, ISBN: 978-1-58488-577-1 2008, 6-1/8 x 9-1/4, 432 pp. Suggested Price: $99.95 / £54.99

Catalog no. C7037, ISBN: 978-1-4200-7037-8 March 2009, 6-1/8 x 9-1/4, 200 pp. Suggested Price: $89.95 / £54.99

Biostatistics

Computational Methods in Biomedical Research

Design and Analysis of Bioavailability and Bioequivalence Studies Computational Pharmacokinetics Anders Källén

Third Edition

125

Shein-Chung Chow

Duke University School of Medicine, Durham, North Carolina, USA

Jen-Pei Liu

Astra Zeneca R&D Lund, Sweden

National Taiwan University, Taipei, Taiwan

Chapman & Hall/CRC Biostatistics Series

Computational Pharmacokinetics outlines the fundamental concepts and models of pharmacokinetics (PK) from a mathematical perspective based on clinically relevant parameters. This important volume covers the analysis of PK data, discusses several physiological aspects to help understand the concepts, and explains processes using real-life data from pharmaceuticals. In addition, the author looks at the relationship between drug concentration and effect, known as PK/pharmacodynamics (PD) modeling. This book will enable readers to thoroughly grasp the computational factors of PK modeling. Catalog no. C6065, ISBN: 978-1-4200-6065-2 2008, 6-1/8 x 9-1/4, 184 pp. Suggested Price: $79.95 / £42.99

Chapman & Hall/CRC Biostatistics Series, 3

Taking into account the regulatory and scientific developments that have occurred since its predecessor, this third edition presents a comprehensive summary of the ever-expanding literature and research in the field. It focuses on regulatory requirements, current scientific and practical issues, and the statistical methodology of designing and analyzing bioequivalence studies. It contains four new chapters, along with several new and updated sections. This edition includes guidelines issued by the FDA, EMEA, and WHO, addresses frequently asked questions, and explores the key topics of sample size determination, meta-analysis, and pharmacokinetics. Catalog no. C6684, ISBN: 978-1-58488-668-6 January 2009, 6-1/8 x 9-1/4, 760 pp. Suggested Price: $99.95 / £55.99

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For more information and a complete list Design and Analysis of Clinical Trials with Time-to-Event Endpoints Edited by

Textbook

Epidemiology

Study Design and Data Analysis, Second Edition Mark Woodward

Karl E. Peace

Mount Sinai Medical Centre, New York, USA

Georgia Southern University, Statesboro, USA

Biostatistics

Chapman & Hall/CRC Biostatistics Series, 30

Chapman & Hall/CRC Texts in Statistical Science Series

Although there are many existing books on survival analysis, no book, until now, reflected the broader applications of this methodology. Including actual examples of clinical trials, this work provides a thorough presentation of time-to-event methodology based on the contributors’ own experiences in various areas of clinical drug development. Written by biostatisticians with numerous years of experience working in biomedical research and clinical development, it covers an array of time-to-event methods, including the design of trials, monitoring, tabular and graphical displays, inferential methods, and analysis and interpretation in a wide variety of drug research and development.

Discussing techniques used in report writing, models for diagnostics, and design issues, this book covers the spectrum of statistical principles and analytical tools used in epidemiological research. This second edition includes new material on systematic evaluation, meta-analysis, regression dilution, case-cohort studies, casecrossover studies, and pooled logistic regression. It also includes a companion website containing data sets for examples and exercises, SAS and Stata code for examples, a sample size calculator, and a SAS floating absolute risk macro. Comprehensive yet accessible, the text favors the use of basic mathematics and practical methods over complicated mathematical proofs.

Catalog no. C6639, ISBN: 978-1-4200-6639-5 April 2009, 6-1/8 x 9-1/4, 632 pp. Suggested Price: $99.95 / £60.99

Catalog no. C415X, ISBN: 978-1-58488-415-6 2005, 6-1/8 x 9-1/4, 872 pp. Suggested Price: $93.95 / £46.99

Textbook

126

Elementary Bayesian Biostatistics Lemuel A. Moyé

University of Texas, Houston, USA Chapman & Hall/CRC Biostatistics Series

Estimating Samples Sizes in Clinical Trials Steven A. Julious

University of Sheffield, Sheffield, England, UK

With numerous exercises and a CD-ROM of data sets and computing code, this lucid introduction explores Bayesian principles and illustrates their application to healthcare research. It reviews the interesting and controversial history of the Bayesian concept and enables a balanced comparison of Bayesian tools with standard frequentist approaches. The book also discusses several important implementations of Bayesian procedures in clinical research, including sample size computations, adaptive randomization, and monitoring procedures. In addition, it shows how to evaluate a healthcare research scenario to determine whether a frequentist or Bayesian approach is most appropriate.

With an emphasis on trials in a regulatory setting, Estimating Samples Sizes in Clinical Trials, provides a hands-on, practical introduction to the calculations performed for sample size estimation in clinical trials. This comprehensive book presents key concepts of clinical trials as well as different trial objectives, including bioequivalence and noninferiority. It covers normal, binary, ordinal, survival, and other types of data. Although some mathematical formulas are required, the book focuses on the application of methods to real-world problems, featuring numerous worked examples that are implemented using SAS. Datasets and code are available for download on the web.

Catalog no. C7249, ISBN: 978-1-58488-724-9 2008, 6-1/8 x 9-1/4, 400 pp. Suggested Price: $83.95 / £46.99

Catalog no. C7397, ISBN: 978-1-58488-739-3 May 2009, 6-1/8 x 9-1/4, 232 pp. Suggested Price: $79.95 / £48.99

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m The Use of Geographic Codes in Cancer Prevention and Control, Research and Practice Edited by

Handbook of Statistics in Clinical Oncology Second Edition Edited by

Gerard Rushton, Marc P. Armstrong, Josephine Gittler, Barry R. Greene, Claire E. Pavlik, Michele M. West, and Dale L. Zimmerman

John Crowley

With recent disease outbreaks and concerns about bioterrorism, interest in the application of GIS to individual level data has grown. Geocoding Health Data presents a state-of-the-art discussion on current technical and administrative developments in geographic information science that will affect the future practice of geocoding. This book examines how geocoded residential addresses can be used to examine the spatial patterns of cancer incidence, staging, survival, and mortality. It also explores how privacy and confidentiality issues can be addressed by focusing on disclosure limitation methods while simultaneously enabling the use of more accurate spatial data on disease distributions.

A compendium of cutting-edge statistical approaches to solving problems in clinical oncology, this book focuses on clinical trials in phases I, II, and III, proteomic and genomic studies, complementary outcomes and exploratory methods. Cancer Forum called the first edition “a good reference book for statisticians who will be designing and analyzing cancer trials.” The second edition includes over 1000 references, more than forty world-renowned contributors, and 300 equations, tables, and drawings. Completely revised while keeping the features that made the first edition a bestseller, this is the best single source for up-to-date statistical approaches to research in clinical medicine.

Catalog no. 8419, ISBN: 978-0-8493-8419-6 2008, 6-1/8 x 9-1/4, 256 pp. Suggested Price: $104.95 / £57.99

Catalog no. DK3170, ISBN: 978-0-8247-2339-2 2006, 6-1/8 x 9-1/4, 640 pp. Suggested Price: $89.95 / £51.99

Handbook of Regression and Modeling

Textbook

University of Iowa, Iowa City, USA

Applications for the Clinical and Pharmaceutical Industries Daryl S. Paulson

BioSciences Laboratories, Inc., Bozeman, Montana, USA

Cancer Research & Biostatistics, Seattle, Washington, USA

Donna Pauler Ankerst

Fred Hutchinson Cancer Center, Washington, USA

Introduction to Randomized Controlled Clinical Trials

127

Second Edition

John N.S. Matthews

The University of Newcastle, UK

Chapman & Hall/CRC Biostatistics Series, 18

Chapman & Hall/CRC Texts in Statistical Science Series, 69

Addressing a variety of topics related to this advanced aspect of statistics, the Handbook of Regression and Modeling provides essential information for researchers, graduate students, and scientists who use regression analysis for biostatistics related to clinical and pharmaceutical research. This text includes exploratory data analysis to evaluate the fit of the model to the actual data. It presents a well-defined procedure for adding or subtracting independent variables to the model variables, with methods that rely on computer software. It also applies statistical forecasting methods when data are serially correlated. Additional material covers simple linear and multiple regressions.

Focusing on the important role that statistical methods play in the analysis of the data collected as well as in the overall clinical trial process, Introduction to Randomized Controlled Clinical Trials provides a concise and accessible introduction to clinical trials. This second edition features new and updated references, examples, exercises, and material on binary outcomes and survival analysis. It features numerous real examples taken from The Lancet, includes exercises at the end of the chapter, and offers solutions in an appendix. Ideal for advanced undergraduate and graduate students, the author uses Minitab and R software throughout the text for implementing the methods presented.

Catalog no. DK3891, ISBN: 978-1-57444-610-4 2007, 6 x 9, 520 pp. Suggested Price: $104.95 / £57.99

Biostatistics

Geocoding Health Data

Catalog no. C6242, ISBN: 978-1-58488-624-2 2006, 6-1/8 x 9-1/4, 304 pp., Soft Cover Suggested Price: $62.95 / £34.99

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For more information and a complete list Textbook

Introduction to Statistics for Biology An Introduction to Stata for Health Researchers Second Edition Svend Juul

University of Aarhus, Denmark

Biostatistics

This book focuses on the analyses used most often in health research. It covers various graph types, calculation commands, commands to modify data set structure, simple analyses of categorical and continuous variables, regression models, incidence and survival analysis, and measurement and diagnosis. This edition encompasses several of the new features in Stata 10, such as the Graph Editor and date-and-time variables, as well as a new section with exercises. The author stresses the importance of good documentation habits to prevent errors and wasting time. He also provides robust examples with downloadable data sets on the book’s website. Catalog no. SZ0440, ISBN: 978-1-59718-044-3 January 2009, 7 3/8 x 9 1/4, 340 pp., Soft Cover Suggested Price: $69.95 / £38.99

Third Edition

Robin H. McCleery

University of Oxford and Wadham College, UK

Trudy A. Watt

Trinity College, Oxford, UK

Tom Hart

Imperial College London and British Antarctic Survey, Cambridge, UK

Focusing on the design and analysis of experiments and surveys in biology, this text contains practical, nontechnical advice on carrying out successful projects and producing clear, informative reports. This edition offers more detailed explanation of elementary probability, greater emphasis on experimental design and data simulation, and a template for executing statistical tests, along with worked examples, updated Minitab analyses and graphics, and a CD-ROM with a free trial version of Minitab. The book also covers sampling, randomization, replication, and controls and explains the models and assumptions behind analysis of variance, linear regression, chisquared tests, and nonparametric tests. Catalog no. C6528, ISBN: 978-1-58488-652-5 2007, 6-1/8 x 9-1/4, 296 pp. Suggested Price: $62.95 / £29.99

Textbook

128

Introduction to Statistical Methods for Clinical Trials Thomas D. Cook and David L DeMets

University of Wisconsin, Madison, USA Chapman & Hall/CRC Texts in Statistical Science Series

This text provides a solid understanding of the various statistical topics relevant to the design, monitoring, and analysis of a clinical trial. It covers basic experimental design, sample size, randomization procedures, interim and survival analyses, quality of life assessment, and longitudinal methods. The book describes all phases of a clinical trial and explores the advantages of and objections to the intent-totreat principle as well as its implementation. With exercises at the end of most chapters, it also illustrates methods using examples with real data from a variety of disease areas, including heart and lung diseases, cancer, and AIDS. Catalog no. C0005, ISBN: 978-1-58488-027-1 2008, 8-1/2 x 11, 464 pp. Suggested Price: $73.95 / £39.99

An Introduction to Survival Analysis Using Stata Second Edition

Mario Cleves, William Gould, Roberto Gutierrez, and Yulia Marchenko Written by the developers of Stata’s widely used survival analysis suite, this book provides the foundation to understand various approaches for analyzing time-to-event data. The authors discuss how survival analysis estimators work and what information they exploit. They also present the syntax, features, and underpinnings of Stata’s survival analysis routines. This edition highlights the new aspects of Stata 10, including its power and sample-size calculations for survival data. Other updates include in-graph at-risk tables for Kaplan–Meier and related curves, survival analysis for survey data, and regression models with flexible functional forms via fractional polynomials. Catalog no. SZ0416, ISBN: 978-1-59718-041-2 2008, 7 3/8 x 9 1/4, 363 pp., Soft Cover Suggested Price: $79.95 / £44.99

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

Textbook

Medical Biostatistics Second Edition

Practical Statistics for Medical Research

Abhaya Indrayan

Douglas G. Altman

Chapman & Hall/CRC Biostatistics Series, 7

Chapman & Hall/CRC Texts in Statistical Science Series, 12

Demonstrating how biostatistics helps manage medical uncertainties, this comprehensive edition covers numerous biostatistical methods used in evidence-based patient management, medical research, and health administration. New chapters describe clinical trials, observational studies, laboratory experiments, survival analysis, logistic regression, and clinimetrics. With more real-world examples, this edition also expands discussions on epistemic uncertainties, crossover designs, and equivalence trials. In addition to conventional statistical procedures, it discusses reliability and validity evaluations, quality control methods, and the robustness of results.

Practical Statistics for Medical Research is a problem-based text for medical researchers, medical students, and others in the medical arena who need to use statistics but have no specialized mathematics background. The author draws on 20 years of experience as a consulting medical statistician to provide clear explanations to key statistical concepts, with a firm emphasis on practical aspects of designing and analyzing medical research. Using real data and including dozens of interesting data sets, this bestselling text gives special attention to the presentation and interpretation of results and the many real problems that arise in medical research.

Catalog no. C8873, ISBN: 978-1-58488-887-1 2008, 6-1/8 x 9-1/4, 824 pp. Suggested Price: $99.95 / £55.99

Catalog no. C7630, ISBN: 978-0-412-27630-9 1991, 6-1/8 x 9-1/4, 624 pp. Suggested Price: $93.95 / £49.99

Textbook

Modelling Survival Data in Medical Research Second Edition

Centre for Statistics in Medicine, Oxford, UK

Biostatistics

University College of Medical Science, Delhi, India

Randomization, Bootstrap and Monte Carlo Methods in Biology Third Edition

129

Bryan F.J. Manly

David Collett

UK Transplant, Bristol, UK

Western EcoSystem Technology, Inc., Laramie, Wyoming, USA

Chapman & Hall/CRC Texts in Statistical Science Series, 57

Chapman & Hall/CRC Texts in Statistical Science Series

Survival analysis is an active field and many advances have emerged over the last eight years. Modelling Survival Data in Medical Research, Second Edition updates and expands on the highly successful first edition, which was praised for its clarity, content, and accessibility. This edition presents up-to-date modelling techniques in survival data analysis, including recent developments in model checking, parametric models, time-dependent variables, and interval censored data. For this edition, the author focused the software sections on SAS-the software of choice in medical and biostatistics. The text includes many practical examples drawn from the medical and pharmaceutical sciences.

Modern computer-intensive statistical methods play a key role in solving many problems across a wide range of scientific disciplines. This new edition of the best-selling Randomization, Bootstrap and Monte Carlo Methods in Biology illustrates the value of a number of these methods with an emphasis on biological applications. It has been updated to reflect developments in methodology, computing, and applications and features extensively revised chapters on bootstrap and Monte Carlo methods that incorporate many new applications. The author also includes new information on time series and multivariate, survival, and growth data and provides an expanded appendix on software for computational statistics.

Catalog no. C3251, ISBN: 978-1-58488-325-8 2003, 6-1/8 x 9-1/4, 408 pp., Soft Cover Suggested Price: $73.95 / £40.99

Catalog no. C5416, ISBN: 978-1-58488-541-2 2007, 6-1/8 x 9-1/4, 480 pp. Suggested Price: $83.95 / £44.99

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For more information and a complete list Sample Size Calculations in Clinical Research Second Edition

Shein-Chung Chow

Duke University School of Medicine, Durham, North Carolina, USA

Jun Shao

University of Wisconsin, Madison, USA

Statistical Analysis for Decision Makers in Healthcare Jeffrey C. Bauer

Hansheng Wang

Futures Practice, ACS Health Care Solutions, Chicago, Illinois, USA

This book explains how the formulas and procedures for sample size calculations can be used in a variety of clinical research and development stages. It presents real-world examples from several therapeutic areas to illustrate clinical and statistical concepts, interpretations, and interactions. The book also explores emerging topics in pharmaceutical research and development, including QT/QTc studies with time-dependent replicates and the use of propensity score analysis in nonrandomized or observational studies. This edition now provides sample size calculations for three major areas of clinical research: dose response studies, microarray studies, and Bayesian approaches.

Designed for the busy healthcare professional who needs to collect, analyze, and/or evaluate data, this readily accessible work explains the fundamental concepts, uses, and misuses of statistics. Without jargon or mathematical formulas, the author introduces the practice of quantitative analysis to provide an understanding of the principles of scientific inquiry, applied to clinical medicine, program evaluation, policy analysis, management, accounting, and research. The book discusses practical scientific methods to show why statistics cannot compensate for bad science or bad data. It will help readers to intelligently evaluate the many numbers that cross their desk in the normal course of business.

Catalog no. C9829, ISBN: 978-1-58488-982-3 2008, 6-1/8 x 9-1/4, 480 pp. Suggested Price: $89.95 / £48.99

Catalog no. K10061, ISBN: 978-1-4398-0076-8 July 2009, 6 x 9, 175 pp., Soft Cover Suggested Price: $49.95 / £30.99

Peking University, Beijing, China

Biostatistics 130

Spatial Epidemiological Approaches in Disease Mapping and Analysis Poh-Chin Lai, Fun-Mun So, and Ka-Wing Chan University of Hong Kong, China

Textbook

Statistical Analysis of Medical Data Using SAS Geoff Der

University of Glasgow, Scotland

Brian S. Everitt

King’s College, University of London, UK

Compiled with method descriptions and step-by-step procedures, the Spatial Epidemiological Approaches in Disease Mapping and Analysis equips readers with skills to prepare health-related data in the proper format, process these data using relevant functions and software, and display the results as mapped or statistical summaries. Describing the wide range of available methods and key GIS concepts for spatial epidemiology, this book illustrates the utilities of the software using real-world data. Additional topics include geographic data models, address matching, geostatistical analysis, universal kriging, point pattern analysis, kernel density, spatiotemporal display, and disease surveillance.

Statistical Analysis of Medical Data Using SAS demonstrates how to use SAS to analyze medical data. Der and Everitt, authors of the best-selling Handbook of Statistical Analyses Using SAS, bring all of their considerable talent and experience to bear in this book. Each chapter briefly describes a particular procedure but focuses on using SAS to implement it and properly interpreting the output. Stepby-step instructions, lucid explanations, clear examples, and many exercises combine to form an outstanding, self-contained guide suitable for medical researchers and statisticians alike to using SAS to analyze medical data. All of the code and data sets used in the book are available for download.

Catalog no. 45466, ISBN: 978-1-4200-4546-8 January 2009, 6-1/8 x 9-1/4, 194 pp. Suggested Price: $79.95 / £55.99

Catalog no. C469X, ISBN: 978-1-58488-469-9 2006, 6-1/8 x 9-1/4, 440 pp. Suggested Price: $88.95 / £49.99

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Strategies and Statistical Methods

Textbook

Statistics for Epidemiology

Edited by

Nicholas P. Jewell

Shein-Chung Chow

Chapman & Hall/CRC Texts in Statistical Science Series, 58

Chapman & Hall/CRC Biostatistics Series

Dennis Cosmatos Wyeth

University of California, Berkeley, USA

Duke University School of Medicine, Durham, North Carolina, USA

Written by one of the top biostatisticians in the field, Statistics for Epidemiology fills a substantial niche by explaining the ideas behind the analysis of epidemiological data without requiring a high level of mathematics or resorting to a “cookbook” format. It covers the basic material for analyzing data that arise from simple epidemiological studies, including case-control and matched studies. Methodologically, it describes stratification techniques for handling confounding and interaction and the logistic regression model. The author uses a case-study approach, following a few simple examples through several method chapters rather than introducing a different example at each stage.

Translational medicine has become increasingly important in pharmaceutical research development. Translational Medicine: Strategies and Statistical Methods examines the critical decisions that must be made to successfully transition from basic to clinical science. With a review of existing processes, the book presents a detailed discussion of alternative research approaches that lead to faster and more accurate decisions on data. It provides insight on biomarker development in early phase clinical trials, integrates genomic and clinical databases for the establishment of medical predictive models in various diseases, and reviews the design and analysis for translating research findings.

Catalog no. C4339, ISBN: 978-1-58488-433-0 2004, 6-1/8 x 9-1/4, 352 pp. Suggested Price: $83.95 / £46.99

Catalog no. C8725, ISBN: 978-1-58488-872-7 January 2009, 6-1/8 x 9-1/4, 224 pp. Suggested Price: $89.95 / £49.99

Textbook

Statistics with Applications in Biology and Geology Preben Blaesild and Jorgen Granfeldt

Mathematical and Experimental Modeling of Physical and Biological Processes

131

H.T. Banks and H.T. Tran

North Carolina State University, Raleigh, USA

University of Aarhus, Denmark

Series: Textbooks in Mathematics, 4

Statistics with Applications in Biology and Geology offers a practical introduction to the fundamental parametric statistical models frequently applied to data analysis in biology and geology. Based on material developed for an introductory course and classroom tested for 10 years, this treatment establishes a firm basis in models, the likelihood method, and numeracy. The presentation incorporates use of the SAS statistical software package, which the authors use to illustrate the statistical tools described. To reinforce understanding of the basic concepts, calculations for the simplest models are also worked through by hand. SAS programs and the data sets used are available on the internet.

Exploring how mathematics is applied to problems in science and engineering, this book discusses mathematical modeling in the context of case study problems that arise in industry and government laboratories. It covers thermal imaging and detection, dynamic properties of beams, acoustics and fluid transport, and size-structured population dynamics for marine populations. The text explains physical and biological relationships and mechanisms through a first principles-based fundamental modeling approach. It also emphasizes model validation through specific laboratory experiments as well as data collection and analysis.

Catalog no. C309X, ISBN: 978-1-58488-309-8 2003, 7 x 10, 568 pp., Soft Cover Suggested Price: $73.95 / £40.99

Biostatistics / Mathematics for Biology & Medicine

Translational Medicine

Catalog no. C7337, ISBN: 978-1-4200-7337-9 January 2009, 6-1/8 x 9-1/4, 298 pp. Suggested Price: $79.95 / £48.99

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For more information and a complete list Spatiotemporal Patterns in Ecology and Epidemiology Niche Modeling Mathematics for Biology & Medicine

Predictions from Statistical Distributions David Stockwell

University of California San Diego, La Jolla, USA Series: Chapman & Hall/CRC Mathematical & Computational Biology, 14

Through theory, applications, and examples of inferences, this book shows how to conduct and evaluate ecological niche modeling (ENM) projects in any area of application. It features a series of theoretical and practical exercises in developing and evaluating ecological niche models using a range of software supplied on an accompanying CD-ROM. These cover geographic information systems, multivariate modeling, artificial intelligence methods, data handling, and information infrastructure. The author then features applications of predictive modeling methods with reference to valid inference from assumptions. This is a seminal reference for ecologists as well as a superb hands-on text for students. Catalog no. C4940, ISBN: 978-1-58488-494-1 2007, 6-1/8 x 9-1/4, 224 pp. Suggested Price: $97.95 / £54.99

Textbook

Theory, Models, and Simulation Horst Malchow

University of Osnabrueck, Germany

Sergei V. Petrovskii

University of Leicester, UK

Ezio Venturino

Università degli Studi di Torino, Italy Series: Chapman & Hall/CRC Mathematical & Computational Biology

Reviewing the significant progress made in understanding spatiotemporal patterning in ecological and epidemiological systems, this resource shows that mathematical modeling and numerical simulations are effective tools in the study of population ecology and epidemiology. It takes a unified approach to population dynamics and epidemiology by presenting several ecoepidemiological models that combine the basic interspecies interactions of population dynamics and the impact of an infectious disease. The book also covers both deterministic and stochastic approaches to spatiotemporal pattern formation in population dynamics and epidemiology and includes a CD-ROM with examples of MATLAB® codes. Catalog no. C6749, ISBN: 978-1-58488-674-7 2008, 6-1/8 x 9-1/4, 464 pp. Suggested Price: $93.95 / £51.99

Optimal Control Applied to Biological Models

132 Suzanne Lenhart

University of Tennessee, Knoxville, USA

John T. Workman

Cornell University, Ithaca, New York, USA Series: Chapman & Hall/CRC Mathematical & Computational Biology

This text introduces the mathematical aspects of optimal control theory and provides insight into the application of this theory to biological models. It examines various problems, such as the continuous time ordinary differential equation, variations of the initial conditions, linear dependence on the control, and free terminal time. The book also features a range of biological applications, including immunology and epidemic disease models, management decisions in harvesting, and resource allocation models. With numerous examples and exercises, the text includes MATLAB® codes throughout, enabling readers to modify the codes for their own applications. Catalog no. C6404, ISBN: 978-1-58488-640-2 2007, 6-1/8 x 9-1/4, 280 pp. Suggested Price: $89.95 / £46.99 In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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3D Fibrous Assemblies: Properties, Applications and Modelling of Three-Dimensional Textile Structures.................. 94

a A Concise Guide to Intraoperative Monitoring........................... 88 A Laboratory Course in Biomaterials.......................................... 62 A Practical Approach to Medical Image Processing................... 80 A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery....................... 102 A Short Introduction to Biomedical Engineering....................... 74 A Theory of the Basal Ganglia and Their Disorders................... 39 Adaptive Design Methods in Clinical Trials.............................. 123 Adaptive Design Theory and Implementation Using SAS and R........................................................................ 123 Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases............................................................... 106 Advanced Nutrition: Macronutrients, Micronutrients, and Metabolism.................................................................................. 41 Advanced Quantitative Microbiology for Foods and Biosystems: Models for Predicting Growth and Inactivation......................... 17 Advanced Signal Processing: Theory and Implementation for Sonar, Radar, and Non-Invasive Medical Diagnostic Systems, Second Edition.............................................................. 83 Advances in Biopreservation.......................................................... 3 Advances in Chromatography, Volume 46.................................. 88 Advances in Chromatography, Volume 47.................................. 88 Advances in Chromatography: Volume 45.................................. 88 Advances in Conjugated Linoleic Acid Research, Volume 3....... 47 Advances in Vagal Afferent Neurobiology.................................... 27 Algorithms in Bioinformatics: A Practical Introduction.......... 115 An Introduction to Biomaterials................................................. 61 An Introduction to Biomedical Optics......................................... 71 An Introduction to Microscopy.................................................... 90 An Introduction to Rehabilitation Engineering......................... 72 An Introduction to Stata for Health Researchers, Second Edition........................................................................... 128 An Introduction to Survival Analysis Using Stata, Second Edition........................................................................... 128 An Introduction to Systems Biology: Design Principles of Biological Circuits..................................................................... 119 Analysis of Growth Factor Signaling in Embryos......................... 6 Angiogenesis: From Basic Science to Clinical Applications......... 3 Animal Clinical Chemistry: A Practical Handbook for Toxicologists and Biomedical Researchers, Second Edition...... 13 Animal Hematotoxicology: A Practical Guide for Toxicologists and Biomedical Researchers....................................................... 13 Animal Lectins: A Functional View................................................ 3 Animal Models of Cognitive Impairment................................... 27 Animal Models of Diabetes, Second Edition: Frontiers in Research....................................................................................... 13 Anti-Angiogenic Functional and Medicinal Foods..................... 41 Antiangiogenic Cancer Therapy.................................................... 3 Anticancer Agents from Natural Products................................. 106 Antimicrobial Susceptibility Testing Protocols........................... 17 Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition....................................................... 98 Application of Solution Protein Chemistry to Biotechnology.... 48 Applied Biomedical Engineering Mechanics.............................. 64 Applying Genomic and Proteomic Microarray Technology in Drug Discovery........................................................................... 107 Artificial Cells, Cell Engineering and Therapy............................. 4 Artificial Muscles: Applications of Advanced Polymeric Nanocomposites........................................................................... 56 Atlas of Functional Neuroanatomy, Second Edition................... 27

Atlas of Human Central Nervous System Development 5 Volume Set.................................................................................. 6 Atlas of Immunology, Second Edition........................................ 10 Automated Image Detection of Retinal Pathology..................... 75

b Bacterial Resistance to Antimicrobials, Second Edition............. 18 Basic Introduction to Bioelectromagnetics, Second Edition...... 80 Basic Pharmacokinetics............................................................ 107 Basic Pharmacology: Understanding Drug Actions and Reactions................................................................................... 107 Basic Statistics and Pharmaceutical Statistical Applications, Second Edition........................................................................... 123 Bayesian Biostatistics and Diagnostic Medicine....................... 124 Bayesian Disease Mapping: Hierarchical Modeling in Spatial Epidemiology............................................................ 124 Behavioral Pharmacology:: Integrating the Experimental Analysis of Behavior & Neuroscience.......................................... 27 Bio-Implant Interface: Improving Biomaterials and Tissue Reactions..................................................................................... 57 Bio-MEMS: Technologies and Applications................................ 59 Bioactive Natural Products: Detection, Isolation, and Structural Determination, Second Edition.......................... 48 Bioactive Peptides...................................................................... 107 Biocatalysis and Agricultural Biotechnology.............................. 83 Biocatalysis and Biotechnology for Functional Foods and Industrial Products...................................................................... 83 Biocatalysis in the Pharmaceutical and Biotechnology Industries............................................................. 96 Bioceramics and Their Clinical Applications............................. 57 Biochemistry and Molecular Biology Compendium.................. 48 Biochips as Pathways to Drug Discovery..................................... 98 Biodefense: Research Methodology and Animal Models............ 13 Bioeffects and Therapeutic Applications of Electromagnetic Energy.......................................................................................... 80 Bioengineering and Biophysical Aspects of Electromagnetic Fields............................................................................................ 81 Biofluid Dynamics: Principles and Selected Applications.......... 67 Biofluid Mechanics: The Human Circulation............................ 65 Bioinformatics Basics: Applications in Biological Science and Medicine, Second Edition..................................... 115 Bioinformatics: A Practical Approach....................................... 115 Biological and Bioenvironmental Heat and Mass Transfer........ 67 Biological and Medical Aspects of Electromagnetic Fields......... 81 Biological Data Mining............................................................. 116 Biological Performance of Materials: Fundamentals of Biocompatibility, Fourth Edition................................................ 57 Biologically Inspired Textiles...................................................... 57 Biology for Engineers.................................................................. 67 Biology of the NMDA Receptor.................................................... 28 Biomaterials................................................................................. 58 Biomaterials and Tissue Engineering in Urology....................... 94 Biomaterials Fabrication and Processing Handbook................. 58 Biomaterials for Treating Skin Loss............................................ 59 Biomaterials: A Nano Approach.................................................. 58 Biomaterials: Principles and Applications.................................. 58 Biomechanical Engineering of Textiles and Clothing............... 65 Biomechanics and Exercise Physiology: Quantitative Modeling................................................................. 65 Biomechanics in Ergonomics, Second Edition.......................... 66 Biomechanics of the Upper Limbs: Mechanics, Modelling and Musculoskeletal Injuries................. 66 Biomechanics: Principles and Applications................................ 65 Biomedical Engineering Fundamentals..................................... 68

Biomedical Engineering Principles............................................ 68 Biomedical Image Analysis......................................................... 75 Biomedical Imaging in Experimental Neuroscience................. 75 Biomedical Nanotechnology....................................................... 68 Biomedical Photonics Handbook................................................ 69 Biomedical Polymers................................................................... 59 Biomedical Technology and Devices Handbook......................... 69 Biomimetics: Biologically Inspired Technologies...................... 69 Biomolecular Action of Ionizing Radiation............................... 81 Biomolecular EPR Spectroscopy................................................. 48 Bionanotechnology: Global Prospects........................................ 92 Biosignal and Biomedical Image Processing............................. 76 Biosignal and Medical Image Processing................................... 76 Biotechnology in Textile Processing........................................... 84 Biotechnology: A Comprehensive Training Guide for the Biotechnology Industry............................................................... 84 Bitter Nemesis: The Intimate History of Strychnine................. 108 Bone Repair Biomaterials........................................................... 59 Brain Aging: Models, Methods, and Mechanisms....................... 28 Brewing: New Technologies......................................................... 84

c Caffeine and Activation Theory: Effects on Health and Behavior................................................................................ 28 Cancer and the Search for Selective Biochemical Inhibitors, Second Edition............................................................................. 49 Cancer Epigenetics........................................................................ 8 Carbohydrate-active enzymes: Structure, Function and Applications................................................................................. 41 Carbohydrates in Food, Second Edition...................................... 41 Carotenoids: Physical, Chemical, and Biological Functions and Properties.............................................................................. 49 Cell Culture Technology for Pharmaceutical and Cell-Based Therapies..................................................................................... 96 Cellular Response to Biomaterials.............................................. 60 Chemical and Biological Properties of Food Allergens.............. 11 Chemical Information Mining: Facilitating LiteratureBased Discovery............................................................................ 98 Chemical Warfare Agents: Chemistry, Pharmacology, and Therapeutics, Second Edition.................................................... 108 Chemicals from Microalgae........................................................ 96 Chemistry and Molecular Aspects of Drug Design and Action.................................................................................. 108 Chemistry and Pharmacology of Anticancer Drugs................. 108 Chemistry for the Life Sciences, Second Edition......................... 49 Chemistry of Natural Products: Amino Acids, Peptides, Proteins, and Enzymes................................................................ 50 Chemistry of Peptide Synthesis.................................................... 50 Chemoarchitectonic Atlas of the Developing Mouse Brain........ 14 Chromosome Nanoscience and Technology............................... 92 Circadian Physiology, Second Edition........................................ 28 Cleanroom Microbiology for the Non-Microbiologist, Second Edition............................................................................. 18 Clinical Embryology: A Color Atlas and Text................................ 7 Clinical Engineering................................................................... 69 Clinical Trials in Oncology, Second Edition............................. 124 Cluster Randomised Trials: A Practical Approach.................... 124 Coarse-Graining of Condensed Phase and Biomolecular Systems......................................................................................... 81 Color Image Processing: Methods and Applications.................. 76 Combination Products: Regulatory Challenges and Successful Product Development................................................ 99

Title Index

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For more information and a complete list

Title Index 134

Combinatorial Pattern Matching Algorithms in Computational Biology using Perl and R........................................................... 116 Comparative Genomics: Basic and Applied Research................ 25 Comprehensive Handbook of Chemical Bond Energies............. 50 Computational Intelligence in Biomedical Engineering........... 70 Computational Intelligence in Medical Imaging: Techniques and Applications....................................................... 76 Computational Methods in Biomedical Research.................... 125 Computational Neuroscience: Realistic Modeling for Experimentalists.......................................................................... 29 Computational Pharmacokinetics............................................ 125 Computational Protein-Protein Interactions........................... 116 Computerized Tomography for Scientists and Engineers.......... 77 Concussive Brain Trauma: Neurobehavioral Impairment & Maladaption, Second Edition...................................................... 29 Copper Amine Oxidases: Structures, Catalytic Mechanisms and Role in Pathophysiology...................................................... 50 CRC Desk Reference for Nutrition, Second Edition.................... 42 CRC Handbook of Chemistry and Physics.................................. 51 Cryptosporidium and Cryptosporidiosis, Second Edition........... 18 Cyclic Nucleotide Phosphodiesterases in Health and Disease.... 51 Cytokines: Stress and Immunity, Second Edition....................... 11

d Data Analysis Tools for DNA Microarrays.................................. 116 Data and Safety Monitoring Committees in Clinical Trials..... 125 Defensive Mutualism in Microbial Symbiosis............................. 18 Degradation Rate of Bioresorbable Materials: Prediction and Evaluation.......................................................... 60 Delivery and Controlled Release of Bioactives in Foods and Nutraceuticals.............................................................................. 42 Dental Biomaterials: Imaging, Testing and Modelling.............. 60 Design and Analysis of Bioavailability and Bioequivalence Studies, Third Edition................................................................ 125 Design and Analysis of Clinical Trials with Time-to-Event Endpoints................................................................................... 126 Design and Use of Relational Databases in Chemistry............... 99 Design Controls for the Medical Device Industry........................ 60 Design of Biomedical Devices and Systems, Second Edition...... 61 Design of Caspase Inhibitors as Potential Clinical Agents......... 51 Designing Usability into Medical Products................................. 61 Desk Reference for Hematology, Second Edition........................ 11 Desk Reference of Clinical Pharmacology, Second Edition..... 109 Development and Uses of Biofortified Agricultural Products..... 84 Diagnostic Ultrasound: Imaging and Blood Flow Measurements..................................................................... 77 Dictionary of Alkaloids, Second Edition with CD-ROM............ 109 Dictionary of Carbohydrates with CD-ROM, Second Edition..... 51 Dictionary of Drugs on CD-ROM® with PDR GenericsTM..... 109 Dictionary of Marine Natural Products with CD-ROM............... 99 Dictionary of Nutraceuticals and Functional Foods................... 42 Dietary Modulation of Cell Signaling Pathways........................... 4 Digital Microfluidic Biochips: Synthesis, Testing, and Reconfiguration Techniques....................................................... 85 Disinfection and Decontamination: Principles, Applications and Related Issues................................ 19 DNA Arrays: Technologies and Experimental Strategies............ 29 DNA Damage Recognition............................................................. 4 DNA Methylation Microarrays: Experimental Design and Statistical Analysis..................................................................... 117 DNA Microarrays and Related Genomics Techniques: Design, Analysis, and Interpretation of Experiments............... 117 DNA Nanotechnology.................................................................. 92

Drug Delivery and Targeting: For Pharmacists and Pharmaceutical Scientists......................................................... 113 Drug Synergism and Dose-Effect Data Analysis....................... 109

e Electrochemical Methods for Neuroscience................................ 30 Elementary Bayesian Biostatistics............................................. 126 Emerging Protein Biotherapeutics.............................................. 97 Encyclopedia of Supramolecular Chemistry.............................. 52 Endocannabinoids: The Brain and Body’s Marijuana and Beyond......................................................................................... 30 Endocrine Disruption Modeling.................................................. 52 Engineering Genetic Circuits...................................................... 70 Enhancement in Drug Delivery................................................ 110 Epidemiology: Study Design and Data Analysis, Second Edition........................................................................... 126 Epigenetics in Biology and Medicine............................................ 8 Ergonomics for Rehabilitation Professionals............................. 66 Essentials of Biotechnology......................................................... 85 Essentials of Human Physiology for Pharmacy, Second Edition........................................................................... 113 Essentials of Law and Ethics for Pharmacy Technicians, Second Edition........................................................................... 114 Estimating Samples Sizes in Clinical Trials............................. 126 Experimental Surgical Models in the Laboratory Rat................ 14

f Fat Detection: Taste, Texture, and Post Ingestive Effects............ 30 Fate of Pharmaceuticals in the Environment and in Water Treatment Systems............................................... 104 Fermentation Microbiology and Biotechnology, Second Edition............................................................................. 19 FLIM Microscopy in Biology and Medicine................................. 88 Fluorescence Detection Techniques for Biomedical Research... 89 Food Composition and Nutrition Tables, 7th Revised and Completed Edition....................................................................... 42 Food Lipids: Chemistry, Nutrition, and Biotechnology, Third Edition............................................................................... 43 Foot and Ankle Motion Analysis: Clinical Treatment and Technology................................................................................... 66 Forensic DNA Analysis: A Laboratory Manual............................. 25 Frontiers in the Neurobiology of Addiction................................. 31 Functional Foods and Biotechnology......................................... 85 Functional Informatics in Drug Discovery............................... 117 Functional Protein Microarrays in Drug Discovery.................... 99 Fundamental Food Microbiology, Fourth Edition...................... 19 Fundamentals of Biochemical Calculations, Second Edition.... 52 Fundamentals of Biofilm Research............................................ 19 Fundamentals of MRI: An Interactive Learning Approach........ 77 Fundamentals of Nanotechnology.............................................. 93 Fundamentals of Natural Computing: Basic Concepts, Algorithms, and Applications.................................................... 117 Fundamentals of Statistical Bioinformatics............................. 118 Fungal Pathogenesis in Plants and Crops: Molecular Biology and Host Defense Mechanisms, Second Edition............ 20 Fungi: Multifaceted Microbes...................................................... 20

g Gaucher Disease............................................................................ 9 Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, Third Edition........................................................ 4 Gene Expression Studies using Affymetrix Microarrays........... 118 Gene Profiles in Drug Design.................................................... 100

Genetics and Randomness............................................................ 9 Genomic Approaches for Cross-Species Extrapolation in Toxicology...................................................................................... 9 Geocoding Health Data: The Use of Geographic Codes in Cancer Prevention and Control, Research and Practice.......... 127 Geomicrobiology, Fifth Edition................................................... 20 Guide to Microbiological Control in Pharmaceuticals and Medical Devices, Second Edition................................................. 20

h Handbook of Analytical Validation........................................... 100 Handbook of Anatomical Models for Radiation Dosimetry........ 70 Handbook of Assay Development in Drug Discovery................ 100 Handbook of Biological Effects of Electromagnetic Fields, Third Edition - 2 Volume Set....................................................... 81 Handbook of Capillary and Microchip Electrophoresis and Associated Microtechniques, Third Edition................................. 52 Handbook of Cell-Penetrating Peptides, Second Edition......... 110 Handbook of Computational Molecular Biology...................... 118 Handbook of Cryo-Preparation Methods for Electron Microscopy................................................................................... 89 Handbook of Dairy Foods and Nutrition, Third Edition............ 43 Handbook of Food Analysis Instruments.................................... 89 Handbook of Food Spoilage Yeasts, Second Edition................... 21 Handbook of Helminthiasis for Public Health............................ 21 Handbook of Hidden Markov Models in Bioinformatics.......... 118 Handbook of Human Immunology, Second Edition.................. 11 Handbook of Laboratory Animal Science, Second Edition: Animal Models, Volume II........................................................... 14 Handbook of Laboratory Animal Science, Second Edition: Animal Models, Volume III......................................................... 14 Handbook of Laboratory Animal Science, Second Edition: Essential Principles and Practices, Volume I.............................. 14 Handbook of listeria monocytogenes.......................................... 21 Handbook of Media for Clinical Microbiology........................... 21 Handbook of Media for Environmental Microbiology, Second Edition............................................................................. 22 Handbook of Microbiological Media for the Examination of Food, Second Edition................................................................... 22 Handbook of Microbiological Media, Third Edition.................. 22 Handbook of Microbiological Quality Control: Pharmaceuticals and Medical Devices...................................... 104 Handbook of Near-Infrared Analysis, Third Edition................... 89 Handbook of New Technologies for Genetic Improvement of Legumes............................................................. 9 Handbook of Nucleic Acid Purification....................................... 26 Handbook of Nutraceuticals and Functional Foods, Second Edition............................................................................. 43 Handbook of Nutrition and Food, Second Edition..................... 43 Handbook of Nutrition in the Aged, Fourth Edition................... 44 Handbook of Optical Sensing of Glucose in Biological Fluids and Tissues........................................................................ 70 Handbook of Pharmaceutical Controlled Release Technology................................................................................... 97 Handbook of Prebiotics............................................................... 44 Handbook of Prebiotics and Probiotics Ingredients: Health Benefits and Food Applications....................................... 44 Handbook of Regression and Modeling: Applications for the Clinical and Pharmaceutical Industries................................... 127 Handbook of Statistics in Clinical Oncology, Second Edition........................................................................... 127 Handbook of Transcription Factor NF-kappaB........................... 12 Handbook of Venoms and Toxins of Reptiles............................ 110 Handbook of Vitamins, Fourth Edition....................................... 44

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Hansen Solubility Parameters: A User’s Handbook, Second Edition............................................................................. 53 High-Throughput Analysis in the Pharmaceutical Industry... 100 High-Throughput Lead Optimization in Drug Discovery........ 101 Histologic Basis of Mouse Endocrine System Development: A Comparative Analysis.................................................................. 15 Human Variation: From the Laboratory to the Field.................... 7 Hyphenated and Alternative Methods of Detection in Chromatography......................................................................... 90

i, j, k Ibuprofen: A Critical Bibliographic Review.............................. 110 Illustrated Dictionary of Biotechnology...................................... 85 Illustrated Dictionary of Immunology, Third Edition................ 12 Image Processing with MATLAB: Applications in Medicine and Biology.................................................................. 78 Immunoassay and Other Bioanalytical Techniques.................. 90 In Vivo Optical Imaging of Brain Function, Second Edition..... 31 Index Nominum: International Drug Directory, Nineteenth Edition.................................................................... 101 Indwelling Neural Implants: Strategies for Contending with the In Vivo Environment..................................................... 31 Infectious Diseases and Pathology of Reptiles: Color Atlas and Text..................................................................... 15 Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents... 53 Insect Physiology and Biochemistry, Second Edition................. 53 Insect Symbiosis, Volume 3......................................................... 22 Instrumental Data for Drug Analysis, Third Edition 6 Volume Set.............................................................................. 111 Intelligent and Adaptive Systems in Medicine............................ 71 Introducing Food Science........................................................... 45 Introduction to Bioinformatics................................................. 119 Introduction to Biomedical Engineering Technology................ 71 Introduction to Machine Learning and Bioinformatics........... 119 Introduction to Macromolecular Binding Equilibria................ 82 Introduction to Molecular Biology, Genomics and Proteomics for Engineers............................................................ 71 Introduction to Nutrition and Metabolism, Fourth Edition....... 45 Introduction to Peptides and Proteins........................................ 53 Introduction to Pharmacology, Third Edition.......................... 111 Introduction to Randomized Controlled Clinical Trials, Second Edition........................................................................... 127 Introduction to Statistical Methods for Clinical Trials............. 128 Introduction to Statistics for Biology, Third Edition................ 128 Ion-Radical Organic Chemistry: Principles and Applications... 54 Joint Replacement Technology................................................... 61 Kinetic Modelling in Systems Biology....................................... 119

l Laboratory Animal Pocket Reference Series, Ten Volume Set.... 16 Laboratory Animal Pocket Reference Series: The Laboratory Canine................................................................ 16 Laboratory Animal Pocket Reference Series: The Laboratory Cat...................................................................... 16 Laboratory Animal Pocket Reference Series: The Laboratory Guinea Pig......................................................... 16 Laboratory Animal Pocket Reference Series: The Laboratory Hamster and Gerbil........................................... 16 Laboratory Animal Pocket Reference Series: The Laboratory Mouse................................................................. 16 Laboratory Animal Pocket Reference Series: The Laboratory Nonhuman Primate.......................................... 16 Laboratory Animal Pocket Reference Series: The Laboratory Rabbit................................................................. 16

Laboratory Animal Pocket Reference Series: The Laboratory Rat...................................................................... 16 Laboratory Animal Pocket Reference Series: The Laboratory Small Ruminant................................................ 16 Laboratory Animal Pocket Reference Series: The Laboratory Swine.................................................................. 16 Laboratory Biosecurity Handbook............................................... 23 Laboratory Quality Assurance: Manual and Templates............ 104 Lactic Acid Bacteria: Microbiological and Functional Aspects, Third Edition............................................................................... 23 Lipid Metabolism and Health...................................................... 45 Lipid-Mediated Signaling.............................................................. 5 Lipoic Acid: Energy Production, Antioxidant Activity and Health Effects............................................................................... 54 Liquid Chromatography-Mass Spectrometry, Third Edition...... 90 Listeria, Listeriosis, and Food Safety, Third Edition.................... 23

m Macroporous Polymers: Production Properties and Biotechnological/Biomedical Applications................................. 86 Making and Using Antibodies: A Practical Handbook................ 12 Managing Pharmacy Practice: Principles, Strategies, and Systems....................................................................................... 114 Managing the Laboratory Animal Facility, Second Edition....... 15 Manual of Stroke Models in Rats................................................ 32 Mathematical and Experimental Modeling of Physical and Biological Processes................................................................... 131 Measurement And Detection Of Radiation................................. 91 Mechanistic Toxicology: The Molecular Basis of How Chemicals Disrupt Biological Targets, Second Edition.............. 26 Medical Biostatistics, Second Edition........................................ 129 Medical Devices and Systems...................................................... 62 Medical Image Analysis Methods................................................ 78 Medical Image Processing, Reconstruction and Restoration: Concepts and Methods................................................................. 78 Medical Image Registration........................................................ 78 Medical Infrared Imaging........................................................... 79 Medical Instrumentation: Accessibility and Usability Considerations............................................................................. 91 Medical Modelling: The Application of Advanced Design and Development Techniques in Medicine........................................ 72 Medical Physics and Biomedical Engineering........................... 72 Medication Treatments for Nicotine Dependence..................... 111 Medicinal Chemistry.................................................................. 101 Medicinal Protein Engineering................................................... 26 Medicine and Evolution: Current Applications, Future Prospects............................................................................ 7 Meta-analysis and Combining Information in Genetics and Genomics................................................................................... 120 Methods for Neural Ensemble Recordings, Second Edition....... 32 Methods in Alcohol-Related Neuroscience Research.................. 32 Methods in Chemosensory Research........................................... 32 Methods in Drug Abuse Research: Cellular and Circuit Level Analyses............................................. 33 Methods in Insect Sensory Neuroscience.................................... 33 Methods in Microarray Normalization..................................... 101 Methods in Pain Research........................................................... 33 Methods in Reproductive Aquaculture: Marine and Freshwater Species..................................................... 7 Methods of Behavior Analysis in Neuroscience, Second Edition............................................................................. 33 Microarray Innovations: Technology and Experimentation.... 120 Microarray Methods and Protocols............................................. 26 Microbial Food Contamination, Second Edition........................ 23

Microbial Limit and Bioburden Tests: Validation Approaches and Global Requirements, Second Edition................................. 24 MicroComputed Tomography: Methodology and Applications.................................................... 79 Micronutrients and Brain Health................................................ 34 Mobile Telemedicine: A Computing and Networking Perspective................................................................................... 72 Modelling Microorganisms in Food............................................ 24 Modelling Survival Data in Medical Research, Second Edition........................................................................... 129 Modern Neurosurgery: Clinical Translation of Neuroscience Advances....................................................................................... 34 Modern Soil Microbiology, Second Edition................................. 24 Molecular and Cellular Biophysics............................................. 82 Molecular and Cellular MR Imaging......................................... 79 Molecular Biotechnology: Principles and Practices................... 86 Molecular Detection of Foodborne Pathogens............................ 24 Monitoring of Respiration and Circulation................................ 73 Motor Cortex in Voluntary Movements: A Distributed System for Distributed Functions.......................... 34 Motor Neurobiology of the Spinal Cord...................................... 34

n Nano-Biophotonics Applications in Advanced Cellular and Molecular Imaging...................................................................... 93 Nanotechnology 2008: CD-ROM................................................. 93 Nanotechnology 2008: Three-Volume Set.................................. 93 Nanotechnology 2008: Volume I, Materials, Fabrication, Particles, and Characterization................................................... 93 Nanotechnology 2008: Volume II, Life Sciences, Medicine, and Bio Materials........................................................ 93 Nanotechnology 2008: Volume III, Microsystems, Photonics, Sensors, Fluidics, Modeling and Simulation.............................. 93 Nanotechnology and Human Health.......................................... 94 Nanotechnology and Tissue Engineering: The Scaffold............ 95 Nanotechnology for Cancer Therapy........................................ 111 Nanotechnology in Biology and Medicine: Methods, Devices, and Applications............................................ 94 Natural Fibers, Biopolymers, and Biocomposites....................... 62 Natural-Based Polymers for Biomedical Applications................ 63 Neural Plasticity and Memory: From Genes to Brain Imaging............................................................................. 35 Neural Plasticity in Adult Somatic Sensory-Motor Systems....... 35 Neural Prostheses for Restoration of Sensory and Motor Function............................................................................ 35 Neuroanatomical Basis of Clinical Neurology........................... 35 Neurobehavioral Genetics: Methods and Applications, Second Edition............................................................................. 36 Neurochemistry of Abused Drugs................................................ 36 Neuroengineering........................................................................ 73 New Concepts in Cerebral Ischemia............................................ 36 Niche Modeling: Predictions from Statistical Distributions..... 132 Nicotinic Receptors in the Nervous System................................. 37 NMR Primer................................................................................. 91 Nonhuman DNA Typing: Theory and Casework Applications.... 10 Nucleic Acids in Innate Immunity.............................................. 12 Nucleotides and Regulation of Bone Cell Function..................... 5 Nutrients and Epigenetics........................................................... 45

Title Index

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135

o, p Optical Imaging Techniques in Cell Biology.............................. 79 Optical Tweezers: Methods and Applications.............................. 82 Optimal Control Applied to Biological Models......................... 132 Optimization in Medicine and Biology....................................... 73

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Title Index 136

Orthopaedic Bone Cements......................................................... 63 Osmotic and Ionic Regulation: Cells and Animals...................... 5 Oxidative Stress and Inflammatory Mechanisms in Obesity, Diabetes, and the Metabolic Syndrome....................................... 46 Paramecium: Genetics and Epigenetics..................................... 10 Parkinson’s Disease..................................................................... 37 Pattern Discovery in Bioinformatics: Theory & Algorithms..... 120 Pediatric Epilepsy Case Studies: From Infancy and Childhood through Adolescence................................................. 37 Pervasive Computing in Healthcare............................................ 73 Pharmaceutical Biotechnology: Fundamentals and Applications, Third Edition......................................................... 97 Pharmaceutical Chemical Analysis: Methods for Identification and Limit Tests............................... 102 Pharmaceutical Dosage Forms and Drug Delivery.................. 114 Pharmaceutical Packaging Technology................................... 102 Pharmacoeconomics: From Theory to Practice....................... 105 Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Fourth Edition.............................. 112 Pharmacy: What It Is and How It Works, Second Edition........ 114 Photoacoustic Imaging and Spectroscopy.................................. 80 Phytochemicals in Nutrition and Health.................................... 46 Phytochemicals: Aging and Health............................................. 46 Phytochemicals: Nutrient-Gene Interactions............................. 46 Plant Biotechnology in Ornamental Horticulture...................... 87 Polymeric Biomaterials, Second Edition, Revised and Expanded................................................................. 63 Polymers for Dental and Orthopedic Applications..................... 63 Polymers in Drug Delivery........................................................ 112 Polyolefin Fibres: Industrial and Medical Applications.............. 74 Polysaccharides: Structural Diversity and Functional Versatility, Second Edition...................................... 106 Practical Guide to Clinical Data Management, Second Edition........................................................................... 106 Practical Handbook of Biochemistry and Molecular Biology, Second Edition CD-ROM............................................................. 54 Practical Handbook of Microbiology, Second Edition................ 25 Practical Statistics for Medical Research.................................. 129 Preventing Medication Errors and Improving Drug Therapy Outcomes: A Management Systems Approach.......................... 115 Primate Audition: Ethology and Neurobiology.......................... 37 Principles and Methods of Toxicology, Fifth Edition................ 112 Principles and Practice of Bioanalysis, Second Edition............. 55 Principles of Biomechanics......................................................... 67 Process Chemistry in the Pharmaceutical Industry................. 102 Process Chemistry in the Pharmaceutical Industry, Volume 2: Challenges in an Ever Changing Climate............... 103 Process Scale Bioseparations for the Biopharmaceutical Industry........................................................................................ 97 Producing Biomolecular Substances with Fermenters, Bioreactors, and Biomolecular Synthesizers............................. 105 Protein Engineering and Design............................................... 120 Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies.................................... 55 Proteins: Energy, Heat and Signal Flow...................................... 83 Python for Bioinformatics......................................................... 121

q, R Quality Assurance and Quality Control in the Analytical Chemical Laboratory: A Practical Approach............................. 105 Quantitative Drug Design: A Critical Introduction, Second Edition........................................................................... 103 R Programming for Bioinformatics.......................................... 121

Randomization, Bootstrap and Monte Carlo Methods in Biology, 3rd Edition................................................ 129 Regulation of Gene Expression by Small RNAs.......................... 10 Reliable Design of Medical Devices, Second Edition.................. 64

s Sample Size Calculations in Clinical Research, Second Edition........................................................................... 130 Scaffolding in Tissue Engineering.............................................. 95 Seafood and Freshwater Toxins: Pharmacology, Physiology, and Detection, Second Edition............................... 112 Sensory-Directed Flavor Analysis................................................. 38 Serotonin Receptors in Neurobiology......................................... 38 Shape Memory Alloys for Biomedical Applications.................... 64 Shape Memory Alloys for Biomedical Applications.................... 74 Signal Transduction in the Retina................................................ 5 Signaling by Toll-Like Receptors.................................................. 6 Six Sigma in the Pharmaceutical Industry: Understanding, Reducing, and Controlling Variation in Pharmaceuticals and Biologics................................................. 105 Sleep: Circuits and Functions...................................................... 39 Smart Biosensor Technology....................................................... 87 Smart Polymers: Applications in Biotechnology and Biomedicine, Second Edition...................................................... 87 Smart Textiles for Medicine and Healthcare: Materials, Systems and Applications........................................... 64 Soft Condensed Matter Physics in Molecular and Cell Biology.................................................................................. 82 Spatial Epidemiological Approaches in Disease Mapping and Analysis............................................................... 130 Spatiotemporal Patterns in Ecology and Epidemiology: Theory, Models, and Simulation............................................... 132 Spectral Techniques In Proteomics............................................. 92 Statistical Analysis for Decision Makers in Healthcare............. 130 Statistical Analysis of Medical Data Using SAS......................... 130 Statistical and Computational Pharmacogenomics................ 121 Statistics for Epidemiology........................................................ 131 Statistics in Human Genetics and Molecular Biology.............. 121 Statistics with Applications in Biology and Geology................. 131 Stochastic Modelling for Systems Biology................................. 122 Structural Bioinformatics: An Algorithmic Approach.............. 122 Surfactants in Personal Care Products and Decorative Cosmetics, Third Edition............................................................. 55 Swine in the Laboratory: Surgery, Anesthesia, Imaging, and Experimental Techniques, Second Edition................................. 17 Systems Biology and Bioinformatics: A Computational Approach....................................................... 122 Systems Biology: Principles, Methods, and Concepts............... 122

t Textbook of Drug Design and Discovery................................... 103 Textbook of Receptor Pharmacology, Third Edition................ 113 The Aspergilli: Genomics, Medical Aspects, Biotechnology, and Research Methods......................................... 8 The Biomedical Engineering Handbook, Third Edition – Three-Volume Set........................................................................ 68 The Chemical Components of Tobacco and Tobacco Smoke.... 49 The Dynamic Synapse: Molecular Methods in Ionotropic Receptor Biology.......................................................................... 29 The Female Brain, Second Edition............................................. 30 The Human Brain During the Early First Trimester.................... 6 The Human Brain During the Late First Trimester...................... 6 The Human Brain During the Second Trimester......................... 6 The Human Brain During the Third Trimester............................ 6

The IACUC Handbook, Second Edition....................................... 15 The Image Processing Handbook, Fifth Edition........................ 77 The Integrated Nervous System................................................... 31 The Measurement, Instrumentation and Sensors Handbook.... 91 The Medical Device R&D Handbook........................................... 62 The Metabolic Pathway Engineering Handbook........................ 86 The Metabolic Pathway Engineering Handbook: Fundamentals.............................................................................. 86 The Metabolic Pathway Engineering Handbook: Tools and Applications................................................................. 86 The Neurobiology of Huntington’s Disease................................. 36 The Organic Chemistry of Sugars............................................... 54 The Physiology of Fishes, Third Edition....................................... 8 The Primate Visual System.......................................................... 38 The Role of the Nucleus of the Solitary Tract in Gustatory Processing.................................................................................... 38 The Somatosensory System: Deciphering the Brain’s Own Body Image............................................................. 39 The Spinal Cord from Gestational Week 4 to the 4th Postnatal Month...................................................................... 6 The Superior Colliculus: New Approaches for Studying Sensorimotor Integration............................................................ 39 The Third Histamine Receptor: Selective Ligands as Potential Therapeutic Agents in CNS Disorders.......................... 40 Therapeutic Peptides and Proteins: Formulation, Processing, and Delivery Systems, Second Edition........................................ 87 Thermal Analysis of Pharmaceuticals...................................... 103 Thermophiles: Biology and Technology at High Temperatures............................................................................... 25 Thin Layer Chromatography in Chiral Separations and Analysis................................................................................. 55 Tissue Engineering...................................................................... 95 Tissue Engineering and Artificial Organs................................... 95 Tissue Engineering Using Ceramics and Polymers.................... 96 Translational Medicine: Strategies and Statistical Methods..... 131 Treatments from Toxins: The Therapeutic Potential of Clostridial Neurotoxins.............................................................. 113 TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades........................................................ 40 Tunable Laser Applications, Second Edition............................... 74 Two-Dimensional Optical Spectroscopy...................................... 56

u-z Ultrasonics: Data, Equations, and Their Practical Uses............. 75 Understanding Autism: From Basic Neuroscience to Treatment..................................................................................... 40 Understanding Drug Release and Absorption Mechanisms: A Physical and Mathematical Approach..................................... 98 Using Artificial Intelligence in Chemistry and Biology: A Practical Guide....................................................................... 123 Vanadium: Chemistry, Biochemistry, Pharmacology and Practical Applications.................................................................. 56 Veterinary Clinical Epidemiology, Third Edition........................ 17 Vitamin Analysis for the Health and Food Sciences, Second Edition............................................................................. 47 Vitamin K in Health and Disease................................................ 47 Vitamins In Foods: Analysis, Bioavailability, and Stability......... 47 Water and Life: The Unique Properties of H20............................ 56 Water-Insoluble Drug Formulation, Second Edition................ 104 XIth International Symposium on Amyloidosis......................... 40

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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a Abbott; A....................................................................................... 57 Abbott; Louise C........................................................................... 14 Abbruzzese; James L....................................................................... 3 Aga; Diana S.............................................................................. 104 Ahluwalia; V.K...................................................................... 50, 101 Ahmed; Hafiz................................................................................. 3 Akira; Shizuo............................................................................... 12 Akoh; Casimir C........................................................................... 43 Allison; David B.................................................................. 117, 120 Allman; A.R.................................................................................. 19 Alon; Uri..................................................................................... 119 Altman; Douglas G.................................................................... 129 Altman; Joseph............................................................................... 6 Aluru; Srinivas........................................................................... 118 Amiji; Mansoor M...................................................................... 111 Ankerst; Donna Pauler.............................................................. 127 Antranikian; Garabed.................................................................. 25 Armstrong; Marc P..................................................................... 127 Arnett; Timothy R.......................................................................... 5 Arnold; Renee J.G....................................................................... 105 Arora; Himanshu......................................................................... 85 Arslan; Orhan............................................................................... 35 Ashtok; Anika............................................................................... 84 Asyali; Musa Hakan..................................................................... 78 Atala; A......................................................................................... 94 Atlas; Ronald M...................................................................... 21, 22 Atwood; Jerry L............................................................................. 52 Azevedo; Helena S........................................................................ 63

b Bagchi; Debasis............................................................................ 41 Baggaley; Keith.......................................................................... 109 Baird; Rosamund M............................................................ 20, 104 Ball; George F.M........................................................................... 47 Bamforth; C.W.............................................................................. 84 Banga; Ajay K............................................................................... 87 Banks; H.T.................................................................................. 131 Banni; Sebastiano........................................................................ 47 Bañuelos; Gary S.......................................................................... 84 Banville; Debra L......................................................................... 98 Bar-Cohen; Yoseph....................................................................... 69 Barber; D.C................................................................................... 72 Bardram; Jakob E........................................................................ 73 Barnes; Frank S............................................................................ 81 Barrow; John D............................................................................ 56 Barry; Brian W............................................................................ 110 Bartfai; Tamas............................................................................. 53 Bassi; Amarjeet S.......................................................................... 87 Bassi; Sebastian......................................................................... 121 Bauer; Jeffrey C.......................................................................... 130 Baust; John G................................................................................. 3 Baust; John M................................................................................ 3 Bayer; Shirley A.............................................................................. 6 Beale; G.H.................................................................................... 10 Beasley; T. Mark......................................................................... 117 Beavo; Joseph A............................................................................ 51 Begg; Rezaul................................................................................ 70 Bell; Suzanne............................................................................... 90 Bender; David A............................................................................ 45 Benedetti; Jacqueline................................................................. 124

Benoiton; N. Leo.......................................................................... 50 Benson; William H......................................................................... 9 Berdanier; Carolyn D....................................................... 41, 42, 43 Berk; John L................................................................................. 40 Bermudez-Rattoni; Federico....................................................... 35 Berry; Elizabeth..................................................................... 77, 80 Best; S.M....................................................................................... 59 Beyenal; Haluk............................................................................. 19 Bhunia; Arun............................................................................... 19 Bibb; Richard............................................................................... 72 Bidlack; Wayne R......................................................................... 46 Black; Jonathan........................................................................... 57 Blæsild; Preben.......................................................................... 131 Blanco; C...................................................................................... 59 Blom; J.A...................................................................................... 73 Blunt; John W............................................................................... 99 Boccaccini; Aldo R....................................................................... 96 Boelsterli; Urs A............................................................................ 26 Borland; Laura M........................................................................ 30 Botana; Luis M........................................................................... 112 Bourtzis; Kostas............................................................................ 22 Bradley; Richard.......................................................................... 60 Bradley; Robert M........................................................................ 38 Braish; Tamim........................................................................... 103 Broemeling; Lyle D.................................................................... 124 Bronzino; Joseph D............................58, 62, 65, 68, 69, 73, 79, 95 Brookes; Murray............................................................................. 7 Brown; B.H................................................................................... 72 Brown; James R............................................................................ 25 Brul; Stanley................................................................................ 24 Bryce; C.F.A................................................................................... 19 Buccafusco; Jerry J................................................................. 27, 33 Buchanan; F. J.............................................................................. 60 Buckingham; John............................................................ 108, 109 Buehler; Lukas K........................................................................ 115 Bulpitt; Andrew............................................................................ 77 Bulte; Jeff W.M.............................................................................. 79 Burkowski; Forbes J.................................................................... 122 Burnham; Keith J......................................................................... 71 Burns; Donald A........................................................................... 89 Burns; Mark D............................................................................ 111 Burnstock; Geoffrey....................................................................... 5

c Cabrita; Elsa................................................................................... 7 Cadenas; Enrique........................................................................... 4 Carlberg; David M........................................................................ 18 Carmen; Andrew.......................................................................... 98 Cartwright; Hugh....................................................................... 123 Cavaco-Paulo; Artur.................................................................... 84 Cavalier; Annie............................................................................. 89 Chakrabarty; Krishnendu............................................................ 85 Chan; Ka-Wing.......................................................................... 130 Chandran; Krishnan B................................................................ 65 Chang; Mark.............................................................................. 123 Channarayappa........................................................................... 86 Chapin; John K............................................................................ 35 Chapman; Kevin.......................................................................... 37 Chattopadhyay; Amitabha........................................................... 38 Chen; Hui..................................................................................... 72 Chen; Jake Y............................................................................... 116 Chen; Taosheng......................................................................... 102

Cho; Minhaeng............................................................................ 56 Cho; Susan Sungsoo.................................................................... 44 Choi; Sang-Woon......................................................................... 45 Chopra; Madhu.......................................................................... 101 Chow; Shein-Chung.......................................... 123, 125, 130, 131 Christensen; Douglas A................................................................ 80 Christensen; Thomas A................................................................ 33 Christian, Jr.; Donnell R............................................................ 104 Chu; Paul K.................................................................................. 58 Ciurczak; Emil W......................................................................... 89 Claiborne; James B........................................................................ 8 Clegg; Robert M........................................................................... 88 Cleves; Mario.............................................................................. 128 Clontz; Lucia................................................................................ 24 Cochran; Jennifer R................................................................... 120 Cohen; Zvi.................................................................................... 96 Colegate; Steven M....................................................................... 48 Collett; David............................................................................. 129 Collins; Christine E...................................................................... 38 Collins; Peter M............................................................................ 51 Colombo; Italo............................................................................. 98 Connor; Anne N........................................................................... 71 Connors; Lawreen H.................................................................... 40 Cook; Thomas D........................................................................ 128 Cooper; Rory A............................................................................. 72 Cope; Timothy C.......................................................................... 34 Cosmatos; Dennis...................................................................... 131 Costaridou; Lena.......................................................................... 78 Cox; Guy....................................................................................... 79 Cragg; Gordon M....................................................................... 106 Craig; Duncan Q.M.................................................................... 103 Cravatt; Benjamin F..................................................................... 53 Cree; Michael J............................................................................. 75 Crommelin; Daan J.A................................................................... 97 Crompton; D.W.T.......................................................................... 21 Cronstein; Bruce N..................................................................... 106 Crooke; Stanley T......................................................................... 98 Crowley; John..................................................................... 124, 127 Cruse; Julius M....................................................................... 10, 12 Curtis; Richard............................................................................. 60

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d Dai; X-Q....................................................................................... 65 Dandelman; D............................................................................. 82 Darlington; Cynthia..................................................................... 30 Datta; Ashim K............................................................................. 67 Datta; Sujay............................................................................... 119 David; Yadin................................................................................. 69 Davies; Audra J............................................................................. 46 Davis; Darren W............................................................................. 3 de Castro; Leandro Nunes.......................................................... 117 De Schutter; Erik.......................................................................... 29 Deak; Tibor................................................................................... 21 Dean; D.A................................................................................... 102 Deb; S........................................................................................... 63 Demain; A.L................................................................................. 19 DeMets; David L......................................................................... 128 Demin; Oleg............................................................................... 119 Demirkaya; Omer........................................................................ 78 DeMuth; James E....................................................................... 123 Denstedt; J.................................................................................... 94 Denyer; Stephen P................................................................ 20, 104

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Author Index

Der; Geoff................................................................................... 130 Deshmukh; S.K............................................................................ 20 Devillers; James............................................................................ 52 Di Giulio; Richard T...................................................................... 9 Di Loreto; Veronica...................................................................... 14 Di Marzo; Vincenzo...................................................................... 30 Di Silvio; L.................................................................................... 60 Diakides; Nicholas A.................................................................... 79 DiLorenzo; Daniel J...................................................................... 73 Doetsch; Paul W............................................................................. 4 Dong; Zigang................................................................................. 4 Donnenberg; Albert D.................................................................. 11 Draghici; Sorin.......................................................................... 116 Driessen; Arnold........................................................................... 25 Drilling; Stephanie.................................................................... 104 Drzal; Lawrence T........................................................................ 62 Duarte; F.J..................................................................................... 74 Dumitriu; Severian.............................................................. 63, 106 Durney; Carl H............................................................................. 80 Dutta; Joydeep.............................................................................. 93 Dworkin; Steven I. ...................................................................... 27 Dwyer; Johanna........................................................................... 43

138

Ebadi; Manuchair................................................................ 37, 109 Ebner; Ford F................................................................................ 35 Eckerman; Keith F........................................................................ 70 Edwards; Jode W......................................................................... 117 Eggersdorfer; Manfred................................................................. 34 Ehrlich; Henry Lutz..................................................................... 20 Eitenmiller; Ronald R................................................................. 47 El-Mansi; E.M.T........................................................................... 19 Eliasson; Ann-Charlotte............................................................... 41 Elisseeff; Jennifer......................................................................... 95 Ellingsen; Jan Erik....................................................................... 57 Ellison; M..................................................................................... 57 Elofsson; Nils Arne....................................................................... 53 Elton; Sarah................................................................................... 7 Ensminger; Dale.......................................................................... 75 Eskin; N.A. Michael...................................................................... 42 Esteller; Manel............................................................................... 8 Etzel; Mark R............................................................................... 97 Evans; David H........................................................................... 5, 8 Evans; E.R.................................................................................. 102 Evans; G.O.................................................................................... 13 Everitt; Brian S........................................................................... 130

f Fachmann; W.............................................................................. 42 Faith; Robert E............................................................................. 11 Fayer; Ronald............................................................................... 18 Feldman; Elaine B....................................................................... 43 Ferrara; Napoleone........................................................................ 3 Finney; John L.............................................................................. 56 Fisher; John P............................................................................... 95 Fliesler; Steven J............................................................................. 5 Floris; Giovanni........................................................................... 51 Foreman; John C........................................................................ 113 Foster; Keith A............................................................................ 113 Francis; Sharron H...................................................................... 51 Freivalds; Andris........................................................................... 66

Fries; Richard......................................................................... 61, 64 Friso; Simonetta........................................................................... 45 Frostig; Ron................................................................................. 31 Fügedi; Péter................................................................................ 54 Fukui; Kiichi................................................................................ 92 Furse; Cynthia.............................................................................. 80 Futerman; Anthony H.................................................................... 9

g Gabrielsson; Johan..................................................................... 112 Gadam; Shishir............................................................................ 97 Gadamasetti; Kumar G...................................................... 102, 103 Galaev; Igor........................................................................... 86, 87 Ganellin; C.R............................................................................. 109 Ganguli; B.N................................................................................ 20 Garti; Nissim................................................................................ 42 Gaudioso; Jennifer....................................................................... 23 Gaur; Rajesh K............................................................................. 10 Gentleman; Robert.................................................................... 121 George; Tony P........................................................................... 111 Ghazanfar; Asif A......................................................................... 37 Ghista; Dhanjoo N....................................................................... 64 Ghosh; Sankar............................................................................. 12 Ghosh; Supriyo............................................................................ 91 Gibb; Alasdair J.......................................................................... 113 Gibson; Glenn R.......................................................................... 44 Gittler; Josephine....................................................................... 127 Gohlmann; Hinrich................................................................... 118 Goldman; Emanuel..................................................................... 25 Goldman; Gustavo H..................................................................... 8 Goldstein; Darlene..................................................................... 120 Gollery; Martin........................................................................... 118 Gomes; Manuela E...................................................................... 63 Good; Robert A............................................................................. 11 Goodwin; Avery C......................................................................... 17 Gopalaswamy; Smita................................................................... 99 Gopalaswamy; Venky................................................................... 99 Goryanin; Igor........................................................................... 119 Gough; Julie E.............................................................................. 96 Gould; William.......................................................................... 128 Granfeldt; Jorgen....................................................................... 131 Graslund; Astrid........................................................................... 53 Grassi; Gabriele............................................................................ 98 Grassi; Mario................................................................................ 98 Green; Lorrence H........................................................................ 25 Green; Stephanie....................................................................... 124 Greene; Barry R.......................................................................... 127 Greenebaum; Ben........................................................................ 81 Grewal; Iqbal S............................................................................ 97 Grigorenko; Elena V..................................................................... 29 Grinberg; Nelu............................................................................. 88 Grogan; Dennis............................................................................ 25 Grushka; Eli................................................................................. 88 Gudmundsen; Ola....................................................................... 47 Guebitz; Georg M......................................................................... 84 Guelcher; Scott A.......................................................................... 61 Guerra; Rudy............................................................................. 120 Gupta; Bhupendra....................................................................... 28 Gupta; Uma................................................................................. 28 Gutierrez; Roberto..................................................................... 128

h Haas; Olivier C. L......................................................................... 71 Habash; Riadh W.Y....................................................................... 80 Hagen; Wilfred Raymond............................................................ 48 Haider; Syed Imtiaz..................................................................... 84 Hajnal; Joseph V........................................................................... 78 Hall; I.H...................................................................................... 102 Hall; William C............................................................................ 39 Hambleton; Peter....................................................................... 113 Hansen; Charles M....................................................................... 53 Hardiman; Gary................................................................... 98, 120 Harper; Charles............................................................................ 56 Harris; Gerald F............................................................................ 66 Hart; Tom................................................................................... 128 Hasko; Gyorgy............................................................................ 106 Hassanien; A................................................................................. 76 Hau; Jann..................................................................................... 14 Hawkes; David J............................................................................ 78 Hayes; A. Wallace....................................................................... 112 Hayes; Richard J......................................................................... 124 Hedaya; Mohsen A...................................................................... 107 Heller; Stefan............................................................................... 40 Hendelman, M.D.; Walter J.................................................... 27, 31 Hepler; Charles D....................................................................... 115 Herbst; Roy S.................................................................................. 3 Hernandez; Maria A................................................................... 107 Herráez; Paz................................................................................... 7 Herson; Jay................................................................................. 125 Hill; Derek L.G............................................................................. 78 Hillery; Anya M.......................................................................... 113 Hobson; Douglas A....................................................................... 72 Hochfeld, Ph.D., C.Ch.E.; William L......................................... 105 Hodges; Norman A..................................................................... 104 Hoffman; E.J................................................................................ 49 Hollinger; Jeffrey O...................................................................... 61 Hollinger; Mannfred A............................................................... 111 Hooper; B.A.................................................................................. 71 Hornyak; Gabor L........................................................................ 93 Hose; D.R...................................................................................... 72 Hou; Ching T................................................................................ 83 Houslay; Miles D.......................................................................... 51 Howard; Gary C............................................................................ 12 Howl; John................................................................................. 107 Hu; Jinlian................................................................................... 94 Hu; Wei-Shou............................................................................... 96 Hughes; Robert E......................................................................... 36 Humbel; Bruno M........................................................................ 89 Humphreys; Peter........................................................................ 31 Huser; Thomas............................................................................. 93 Huston; Ronald............................................................................ 67

i Ilyin; Sergey............................................................................... 117 Indrayan; Abhaya...................................................................... 129 Ishii; Ken J.................................................................................... 12

j Jacobowitz; David M.................................................................... 14 Jan; Jirí......................................................................................... 78 Jansson; Janet K........................................................................... 24 Jarvis; Judith K............................................................................. 43

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Jedrychowski; Lucjan................................................................... 11 Jelinek; Herbert............................................................................ 75 Jenkins; Mike............................................................................... 59 Jewell; Nicholas P....................................................................... 131 Jiang; J.......................................................................................... 76 Johansen; Torben....................................................................... 113 Johnson; Arthur T................................................................... 65, 67 Johnson; Iain D............................................................................ 89 Jones; Byron C.............................................................................. 36 Jones; Sarah............................................................................... 107 Julious; Steven A........................................................................ 126 Juul; Svend................................................................................. 128

k Kaas; Jon H................................................................................... 38 Källén; Anders............................................................................ 125 Karch, MD, FFFLM; Steven B....................................................... 36 Kaser; Matthew R......................................................................... 12 Kaufman; Matthew...................................................................... 15 Kelly; William N......................................................................... 114 Khattree; Ravindra..................................................................... 125 Khudyakov; Yury E....................................................................... 26 Kim; Kwang J............................................................................... 56 King; Paul H................................................................................ 61 Kingston; David G. I.................................................................. 106 Kirti; P. B........................................................................................ 9 Kisselev; Oleg G.............................................................................. 5 Kittler; Josef T............................................................................... 29 Kleinstreuer; Clement.................................................................. 67 Knopf; George K........................................................................... 87 Kokubo; Tadashi.......................................................................... 57 Konat; Gregory W........................................................................... 6 Konieczka; Piotr......................................................................... 105 Konopka; A.K.............................................................................. 122 Koob; George F............................................................................. 31 Kourounakis; P.N....................................................................... 108 Kow; Yoke Wah............................................................................... 4 Kowalska; Teresa.......................................................................... 55 Kozlowski; Ryszard...................................................................... 84 Kramer; John K.G......................................................................... 47 Kraut; Heinrich............................................................................ 42 Krogsgaard-Larsen; Povl........................................................... 103 Kruger; Lawrence......................................................................... 33 Krull; Ira S................................................................................. 100 Kshirsagar; Tushar..................................................................... 101 Kucklick; Theodore R.................................................................. 62 Kuhn; Cynthia M......................................................................... 31 Kumar; Ashok.............................................................................. 86 Kumar; Lalita S............................................................................ 50 Kumar; Sanjiv.............................................................................. 50 Kumar; Shrawan......................................................................... 66 Kumar; T.S. Sampath.................................................................. 58

l Lai; Daniel T.H............................................................................. 70 Lai; Poh-Chin............................................................................ 130 Landen, Jr; W. O........................................................................... 47 Landers; James P.......................................................................... 52 Landrum; John T......................................................................... 49 Lane; Stephen M.......................................................................... 93 Langel; Ulo........................................................................... 53, 110 Lapasin; Romano........................................................................ 98

Laurencin; Cato T........................................................................ 95 Lawford; P.V.................................................................................. 72 Lawson; Andrew......................................................................... 124 le Coutre; Johannes...................................................................... 30 Lee; Eva K..................................................................................... 73 Lehnert; Shirley........................................................................... 81 Leitner; David M.......................................................................... 83 Lenhart; Suzanne...................................................................... 132 Levin; Edward D..................................................................... 27, 37 Levin; Robert E............................................................................ 85 Levy; Daniel E.............................................................................. 54 Lewandowski; Zbigniew............................................................... 19 Lewis; Kim.................................................................................... 18 Lewis; Robert E...................................................................... 10, 12 Li; Y......................................................................................... 65, 87 Lidbury; Brett A.......................................................................... 100 Lide, David R................................................................................ 51 Liedtke; Wolfgang B..................................................................... 40 Lim; Gino J................................................................................... 73 Lin; Min..................................................................................... 121 Lin; Rick C.S................................................................................ 36 Lin; Zhi-Qing............................................................................... 84 Linton; Steven D.......................................................................... 51 Liu; Dongyou................................................................... 21, 24, 26 Liu; Jen-Pei................................................................................ 125 Liu; Rong................................................................................... 104 Liu; Xuanyong............................................................................. 58 Liu; Yuan...................................................................................... 32 Lloyd; Andrew W......................................................................... 113 Lo; Donald C................................................................................ 36 Lonardi; Stefano........................................................................ 116 Losso; Jack N................................................................................ 41 Lovinger; David M........................................................................ 32 Lukac; Rastislav........................................................................... 76 Lukey; Brian J............................................................................ 108 Lundblad; Roger L................................................................. 48, 54 Luo; Yu-Ran................................................................................. 51 Luppi; Pierre-Hervé...................................................................... 39 Lynden-Bell; Ruth M................................................................... 56 Lyngstadaas; S. Petter.................................................................. 57

m Ma; Peter X................................................................................... 95 Mackessy; Stephen P................................................................... 110 Madsen; Ulf................................................................................ 103 Mahalingam; Suresh................................................................. 100 Mahato; Ram I.......................................................................... 114 Malchow; Horst.......................................................................... 132 Malsch; Ineke............................................................................... 94 Malsch; Neelina H........................................................................ 68 Manivannan; Gurusamy............................................................. 19 Manly; Bryan F.J......................................................................... 129 Mano; Joao F................................................................................ 63 Marchenko; Yulia...................................................................... 128 Marks; Richard M........................................................................ 66 Marques; Alexandra P.................................................................. 63 Marsili; Ray.................................................................................. 38 Marth; Elmer H............................................................................ 23 Martin; Yvonne C....................................................................... 103 Mascie-Taylor; C.G. Nicholas........................................................ 7 Matchett; Christian C................................................................. 111 Mathur; Sunil............................................................................ 118

Matson; Robert S.................................................................. 26, 107 Matthews; John N.S.................................................................... 127 Mattiasson; Bo....................................................................... 86, 87 Mayazaki; S............................................................................ 64, 74 McBean; Lois D............................................................................ 43 McCleery; Robin H..................................................................... 128 McClintock; J. Thomas................................................................ 25 McConnell; John S..................................................................... 105 McCormick; Donald B................................................................. 44 McCorry; Laurie Kelly................................................................ 113 McGloin; David............................................................................ 82 Meibohm; Bernd.......................................................................... 97 Meskin; Mark S............................................................................ 46 Michael; Adrian C........................................................................ 30 Michailidis; George.................................................................... 119 Michniak; Bozena B.................................................................... 68 Mihailidis; Alex............................................................................ 73 Mikos; Antonios G........................................................................ 95 Miller Coyle; Heather................................................................... 10 Miller; Gregory D......................................................................... 43 Miller; Robert............................................................................... 39 Miller; Thomas A......................................................................... 22 Mills, III; Terry........................................................................... 111 Min; David B................................................................................ 43 Minor; Lisa K.............................................................................. 100 Misra; Manjusri........................................................................... 62 Mitra; Sushmita......................................................................... 119 Modo; Michel M.J......................................................................... 79 Moffatt; Robert J........................................................................... 45 Mohanty; Amar K......................................................................... 62 Mojarrad; Mehran....................................................................... 56 Moldin; Steven O.......................................................................... 40 Molloy; Justin............................................................................... 82 Molyneux; Russell J..................................................................... 48 Mondovi; Bruno........................................................................... 51 Montmayeur; Jean-Pierre............................................................ 30 Moore; James............................................................................... 69 Moore; John J............................................................................... 93 Moorthy; Krish............................................................................. 52 Mormède; Pierre.......................................................................... 36 Morris; Keith................................................................................ 90 Morris; Simon Conway................................................................ 56 Moschovakis; Adonis . ................................................................. 39 Moss; Stephen J............................................................................ 29 Moulton; Lawrence H................................................................ 124 Moxon; Karen A........................................................................... 35 Moyé; Lemuel A.......................................................................... 126 Munro; Murray H.G..................................................................... 99 Munshi; Prabhat.......................................................................... 77 Murgo; Anthony J......................................................................... 11 Murphy; Eric J................................................................................ 5 Myers; Chris J............................................................................... 70

Author Index

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n Naik; Dayanand N..................................................................... 125 Nair; Lakshmi S........................................................................... 95 Najarian; Kayvan....................................................................... 122 Namiesnik; Jacek....................................................................... 105 Nano Science & Technology Institute......................................... 93 Nation; James L............................................................................ 53 Nelson; Randall J......................................................................... 39 Neuman; Michael R.................................................................... 69

Rest of the World Tel: +44 (0) 1235 400 524 • Fax: +44 (0) 1235 400 525 e-mail: (UK) uk.trade@tandf.co.uk • (International) international@tandf.co.uk

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For more information and a complete list Neves; N.M.................................................................................... 63 Newman; David J....................................................................... 106 Newman; Dianne K...................................................................... 20 Nicolelis; Miguel A.L.................................................................... 32 Niessen; Wilfried M.A................................................................... 90 Nikitin; Alexander Yu................................................................... 15 Northrop; Robert B...................................................................... 71 Nunnally; Brian K...................................................................... 105 Nussinov; Ruth.......................................................................... 116

Author Index

O’Brien; Tom............................................................................... 51 O’Donnell; TJ............................................................................... 99 O’Gorman; Maurice R.G............................................................. 11 O’Higgins; Paul............................................................................. 7 O’Lenick; Anthony....................................................................... 55 Ohnabe; Hisaichi......................................................................... 72 Ollis, Jr.; Robert J........................................................................ 111 Omaye; Stanley T......................................................................... 46 Onaivi; Emmanuel S................................................................... 30 Orgill; D....................................................................................... 59 Osmani; Stephen A........................................................................ 8 Otles; Semih................................................................................. 89 Ouwehand; Arthur C.................................................................... 23 Ozturk; Sadettin........................................................................... 96

p, q

140

Pachouri; Suparna S................................................................... 85 Packer; Lester............................................................... 4, 34, 46, 54 Padgett; Miles J............................................................................ 82 Page; Grier P............................................................................... 117 Palaniswami; Marimuthu........................................................... 70 Paliyath; Gopinadhan................................................................. 85 Papanicolaou; Andrew C............................................................. 88 Parida; Laxmi............................................................................ 120 Pariza; Michael W........................................................................ 47 Park; Joon B................................................................................. 58 Park; K-H..................................................................................... 41 Park; Sheldon J.......................................................................... 120 Parker; Rolland S........................................................................ 29 Patel; Mulchand S....................................................................... 54 Patel; Ramesh N.......................................................................... 96 Paulson; Daryl S........................................................................ 127 Pavlik; Claire E.......................................................................... 127 Peace; Karl E.............................................................................. 126 Pedersen; Ole............................................................................. 102 Pei; Yan........................................................................................ 87 Peleg; Micha................................................................................ 17 Perfetti; Thomas A....................................................................... 49 Periasamy; Ammasi..................................................................... 88 Perkins; Theodore...................................................................... 119 Peterson; Andrew M................................................................... 114 Peterson; Donald R...................................................................... 65 Petronis; Arturas........................................................................ 117 Petrovskii; Sergei V..................................................................... 132 Pfeiffer; Ronald F......................................................................... 37 Planell; J.A.................................................................................... 59 Plataniotis; Konstantinos N......................................................... 76 Plotnikoff; Nicholas P.................................................................. 11 Pometto; Anthony L..................................................................... 85 Poon; W.C.K.................................................................................. 82

Prakash; S...................................................................................... 4 Predki; Paul F............................................................................... 99 Preer, Jr.; John R........................................................................... 10 Priyadarshy; Satyam.................................................................... 92 Prokscha; Susanne.................................................................... 106

r Rainsford; K.D............................................................................ 110 Ramakrishna; Seeram................................................................. 58 Ramalingam; Murugan.............................................................. 58 Randolph; R. Keith...................................................................... 46 Rangayyan; Rangaraj M............................................................. 75 Rashidi; Hooman H................................................................... 115 Rathinavelu; Appu..................................................................... 107 Ray; Bibek.................................................................................... 19 Reading; Mike............................................................................ 103 Refinetti, Ph.D.; Roberto............................................................. 28 Reichert; William M.................................................................... 31 Reilly; Cavan.............................................................................. 121 Reis; R.L....................................................................................... 63 Reisman; Stanley......................................................................... 68 Reisner; David E.......................................................................... 92 Rekka; E.A.................................................................................. 108 Revell; P.A..................................................................................... 61 Rhein; Linda D............................................................................ 55 Rho; Jong M................................................................................. 37 Riddle; David R............................................................................ 28 Riehle; Alexa................................................................................ 34 Rigalli; Alfredo............................................................................. 14 Ritter; Arthur B............................................................................ 68 Rittgers; Stanley E........................................................................ 65 Robb; Frank................................................................................. 25 Roberfroid; Marcel B.................................................................... 44 Roberson; James Conrad........................................................... 111 Roberts; Andy............................................................................. 109 Roberts; Timothy......................................................................... 75 Robles; Vanesa............................................................................... 7 Rockett; Bernard.......................................................................... 49 Rodgman; Alan............................................................................ 49 Romano, Jr.; James A................................................................. 108 Rosenberger; Thad A...................................................................... 5 Rossi; John J................................................................................. 10 Rubenstein; John L.R................................................................... 40 Rucker; Robert B.......................................................................... 44 Rushton; Gerard........................................................................ 127 Russ; John C................................................................................. 77 Ruvinsky; Anatoly.......................................................................... 9 Ryser; Elliot T............................................................................... 23

s Sahoo; Prasanna K...................................................................... 78 Salem; Harry.............................................................................. 108 Salerno; Reynolds M.................................................................... 23 Salminen; Seppo.......................................................................... 23 Salyers; Abigail............................................................................. 18 Salz; Ulrich.................................................................................. 63 Sarbadhikari; S.N........................................................................ 74 Sater; Amy...................................................................................... 6 Savioli; Lorenzo........................................................................... 21 Schaefer; G................................................................................... 76 Schatzlein; Andreas G................................................................ 112

Schlossman; Mitchell.................................................................. 55 Schreiber; Gideon...................................................................... 116 Schwalbe; Richard....................................................................... 17 Segal; Richard........................................................................... 115 Seldin; David C............................................................................ 40 Sem; Daniel S.............................................................................. 92 Semmlow; John L........................................................................ 76 Sewell; Robert D.E....................................................................... 55 Shafrir; Eleazar............................................................................ 13 Shahidi; Fereidoon...................................................................... 41 Shahinpoor; Mohsen................................................................... 56 Shalaby; Shalaby W..................................................................... 63 Shalliker; R. Andrew.................................................................... 90 Shankar; Latha............................................................................ 92 Shao; Jun................................................................................... 130 Shaw; Jei-Fu................................................................................. 83 Sherma; Joseph............................................................................ 55 Shetty; Kalidas............................................................................. 85 Shewfelt; Robert L........................................................................ 45 Shinton; N.K................................................................................ 11 Shone; Clifford C........................................................................ 113 Shukla; Abhinav A....................................................................... 97 Shung; K. Kirk............................................................................. 77 Siede; Wolfram............................................................................... 4 Sies; Helmut........................................................................... 34, 46 Silverman; Jerald......................................................................... 15 Simon; Mathew J........................................................................ 111 Simon; Sidney A........................................................................... 32 Simons; Claire............................................................................. 55 Sindelar; Robert D....................................................................... 97 Skinner; Christopher R................................................................ 31 Skinner; Martha........................................................................... 40 Smallwood; R.H........................................................................... 72 Smith; Barry D............................................................................. 28 Smith; H. John............................................................................. 55 Smith; Paul J................................................................................ 53 Smith; Peter A.............................................................................. 66 Smith; Ronald D.......................................................................... 17 Smolke; Christina D.................................................................... 86 Snyder; James W........................................................................... 21 So; Fun-Mun.............................................................................. 130 Soboyejo; Winston O.................................................................... 58 Sobti; R.C..................................................................................... 85 Somasundaran; P......................................................................... 55 Soper; Steven A............................................................................. 59 Souci; Siegfried W........................................................................ 42 Spehner; Daniele......................................................................... 89 Splinter; R.................................................................................... 71 Stafford; Phillip......................................................................... 101 Stamford; Bryant......................................................................... 45 Steed; Jonathan W........................................................................ 52 Steele-Moore; Lynn...................................................................... 17 Stergiopoulos; Stergios................................................................ 83 Stock; Stuart R............................................................................. 79 Stockwell; David......................................................................... 132 Story; Molly Follette..................................................................... 91 Strandberg; Kenneth M.............................................................. 114 Straub; John Edward.................................................................... 83 Street; Laurence J......................................................................... 71 Stromgaard; Kristian................................................................. 103 Stulen; Foster B............................................................................ 75

In North & South America Tel: 1-800-272-7737 • Fax: 1-800-374-3401 (Outside the U.S.) Tel: 1-561-994-0555 • Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

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o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

t Taber; Harry................................................................................. 18 Takeuchi; Esther S....................................................................... 56 Tallarida; Ronald J.................................................................... 109 Talloen; Willem......................................................................... 118 Tamir; Snait................................................................................. 42 Teixeira; Marie B.......................................................................... 60 Templeton; Nancy Smyth.............................................................. 4 Thurston; David E...................................................................... 108 Tibbals; Harry F............................................................................ 93 Todres; Zory Vlad.......................................................................... 54 Tollefsbol; Trygve........................................................................... 8 Torres; Monica S.......................................................................... 19 Touitou; Elka............................................................................. 110 Tracey; Alan S.............................................................................. 56 Tramontano; Anna.................................................................... 119 Tran; H.T.................................................................................... 131 Trevors; Jack T.............................................................................. 24 Triggle; David J.......................................................................... 109 Tsoulfanidis; Nicholas................................................................. 91 Tuchin; Valery V............................................................................ 70 Turner; Dennis A.......................................................................... 34 Tuszynski; Jack A.......................................................................... 82

u Uchegbu; Ijeoma F..................................................................... 112 Ugbolue; S.C.O............................................................................. 74 Ulijaszek; Stanley........................................................................... 7 Undem; Bradley J......................................................................... 27 Ushiki; Tatsuo.............................................................................. 92

v Vaadia; Eilon................................................................................ 34 Valiente; Gabriel........................................................................ 116 van Bruggen; Nick....................................................................... 75 van Elsas; Jan Dirk....................................................................... 24 van Emon; Jeanette M................................................................. 90 van Gerwen; Suzanne.................................................................. 24 Van Hoosier, Jr.; Gerald L............................................................. 14 Van Langenhove; L...................................................................... 64 VanDongen; Antonius M.............................................................. 28 Vasta; Gerardo R............................................................................ 3 Venn; Richard F............................................................................ 55 Venturino; Ezio.......................................................................... 132 Vidhyasekaran; P.......................................................................... 20 Vo-Dinh; Tuan....................................................................... 69, 94

Vohora; Divya............................................................................... 40 von Heijne; N.G.H........................................................................ 53 von Maltzahn; Wolf W.................................................................. 69 von Wright; Atte........................................................................... 23 Voth; Gregory A............................................................................ 81

w Wan; Dadong............................................................................... 73 Wang-Fischer; Yanlin.................................................................. 32 Wang; Hansheng........................................................................ 130 Wang; Lihong.............................................................................. 80 Wang; Perry G............................................................................ 100 Wang; Sun-Chong..................................................................... 117 Wang; Wanjun............................................................................. 59 Waterhouse; Barry D.................................................................... 33 Watson; Ronald Ross................................................................... 44 Watson; Timothy.......................................................................... 60 Watt; Trudy A.............................................................................. 128 Wax; Richard G............................................................................ 18 Webster; John G............................................................................ 91 Weiner; Dan............................................................................... 112 Weinreich; Daniel........................................................................ 27 West; Michele M......................................................................... 127 White; James F.............................................................................. 19 Whitman; Malcolm....................................................................... 6 Wiklund; Michael E..................................................................... 61 Wilcox; Stephen B........................................................................ 61 Wildman; Robert E.C................................................................... 43 Wilkinson; Darren J................................................................... 122 Willsky; Gail R............................................................................. 56 Wilson; Charles L......................................................................... 23 Winters; Jack M............................................................................ 91 Wise; Donald L............................................................................. 97 Wong; Joyce Y............................................................................... 58 Woodbury; Charles P.................................................................... 82 Woodward; Mark........................................................................ 126 Workman; John T....................................................................... 132 Wu; Rongling............................................................................. 121

x Xian; Wujing................................................................................ 62 Xiao; Lihua.................................................................................. 18 Xiao; Yang.................................................................................... 72 Xu; Xie George............................................................................. 70

Author Index

Su; Fei.......................................................................................... 85 Suckow; Mark A..................................................................... 15, 16 Sugiura; Takayuki....................................................................... 30 Sung; Wing-Kin......................................................................... 115 Surh; Young-Joon.......................................................................... 4 Suttie; John W......................................................................... 44, 47 Sutton; Raul................................................................................. 49 Swarbrick; James....................................................................... 113 Swartz; Michael E...................................................................... 100 Swearengen; James R.................................................................. 13 Swindells; Peter G........................................................................ 49 Swindle; M. Michael.................................................................... 17 Swiss Pharmaceutical Society................................................... 101 Szabo; Csaba.............................................................................. 106 Szabo; Laszlo F........................................................................... 109

141

y Yasukouchi; Akira.......................................................................... 7 Ye; Lin........................................................................................... 47 Ye; Shui Qing............................................................................. 115 Yoganathan; Ajit P........................................................................ 65 Yoneyama; T........................................................................... 64, 74 Yue; Eddy W.................................................................................. 53 Yurawecz; Martin P...................................................................... 47

z Zempleni; Janos..................................................................... 41, 44 Zietman; Anthony.......................................................................... 7 Zimmerman; Dale L.................................................................. 127 Zimran; Ari..................................................................................... 9 Zorko; Matjaz............................................................................... 53 Zouridakis; George................................................................. 69, 88 Zwietering; Marcel....................................................................... 24

Rest of the World Tel: +44 (0) 1235 400 524 â&#x20AC;˘ Fax: +44 (0) 1235 400 525 e-mail: (UK) uk.trade@tandf.co.uk â&#x20AC;˘ (International) international@tandf.co.uk

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plc

CRC Press • Taylor & Francis • Chapman & Hall/CRC • Auerbach Publications • Productivity Press

Visit us online at

www.crcpress.com

In the Americas Sales Office - CRC Press 6000 Broken Sound Parkway, NW, Suite 300, Boca Raton, FL 33487, U.S.A. Within the Continental USA - Tel: 800-272-7737 • Fax: 800-374-3401 • orders@taylorandfrancis.com Outside the Continental USA - Tel: 561-994-0555 • Fax: 561-361-6018 • international.orders@taylorandfrancis.com

Senior Vice President of Sales

Dennis Weiss Tel: 561-998-2510 Fax: 561-998-2580 e-mail: dennis.weiss@taylorandfrancis.com

Customer Service

Sales Agents

Angela Williams Tel: 800-272-7737 ext. 6091 Fax: 800-374-3401 e-mail: angela.williams@taylorandfrancis.com

Premium/Custom Sales

Michael Dulisse Tel: 561-998-2582 Fax: 561-361-6049 e-mail: michael.dulisse@taylorandfrancis.com

Academic Sales

Susie Carlisle Tel: 561-998-2538 Fax: 561-361-6049 e-mail: susie.carlisle@taylorandfrancis.com

Retail Bookstores

Ryan Prior Tel: 561-998-2516 Fax: 561-361-6049 e-mail: ryan.prior@taylorandfrancis.com

Evelyn Elias Tel: 561-361-6010 Fax: 561-361-6049 e-mail: evelyn.elias@taylorandfrancis.com

Library/Medical Wholesalers

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Jennifer Strong Tel: 212-216-7851 Fax: 212-244-1563 e-mail: jennifer.strong@taylorandfrancis.com

Milton Park Sales Office - Taylor & Francis Group (Books Ltd) 2 Park Square, Milton Park, Abingdon, Oxon, OX14 4RN, UK

Group Sales Director

Academic Representatives (UK)

Christoph Chesher Tel: +44 (0) 20 7017 6194 Fax: +44 (0) 20 7017 6748 e-mail: christoph.chesher@tandf.co.uk

Tim Page Higher Education Sales Manager Mobile: 07824 690646 e-mail: tim.page@tandf.co.uk

International Sales Director Graham Crossley Tel: +44 (0) 20 7017 6048 Fax: +44 (0) 20 7017 6748 e-mail: graham.crossley@tandf.co.uk

Head of UK Sales Nick Perry Tel: +44 (0) 20 7017 6132 Fax: +44 (0) 20 7017 6732 e-mail: nick.perry@tandf.co.uk

Corporate and Institutional Sales Alfred Lea Tel: +44 (0) 20 7017 6273 Fax: +44 (0) 20 7017 6732 e-mail: cis@tandf.co.uk

142

Latin American Sales

UK Sales Administrator Judith Cavell Tel: +44 (0) 20 7017 6191 Fax: +44 (0) 20 7017 6732 e-mail: judith.cavell@tandf.co.uk

Central and South America and Mexico Michael Dulisse Sales Office, Boca Raton, FL Taylor & Francis 6000 Broken Sound Parkway, NW, Suite 300, Boca Raton, FL 33487, USA Tel: 561-998-2582 Fax: 561-361-6049 e-mail: michael.dulisse@taylorandfrancis.com Ethan E. Atkin Cranbury International LLC 7 Clarendon Ave, Suite 2 Montpelier, VT 05602, USA Tel: +1 802 223 6565 Fax: +1 802 223 6824 e-mail: eatkin@cranburyinternational.com

CATBMS_K00164_2009 Cat.indd 142

China Liaison Office

Yan Pei Manager Taylor & Francis Room 523 European and Japanese Enquiries Resource Building No. 151 North Street Zhongguancun Lucy Astone Beijing, China 100080 International Sales Support Coordinator P.O. Box: 8762 Tel: +44 (0) 20 7017 6149 Tel/Fax: +86 (10) 58876523 Fax: +44 (0) 20 7017 6748 e-mail: yanpei@tandf.co.sg e-mail: lucy.astone@tandf.co.uk

International Enquiries Kate Pearce International Sales Support Manager (Books) Tel: +44 (0) 20 7017 6053 Fax: +44 (0) 20 7017 6748 e-mail: kate.pearce@tandf.co.uk

South Asian, Middle Eastern and African Enquiries

Foreign Rights

Adele Parker e-mail: adele.parker@tandf.co.uk

Customer Services Taylor & Francis Bookpoint 130 Milton Park, Abingdon, Oxon OX14 4SB Tel: +44 (0) 1235 400 524 Fax: +44 (0) 1235 400 525 e-mail (UK): uktrade@tandf.co.uk e-mail (internationally): international@tandf.co.uk www.hodderheadline.co.uk/Bookpoint

Standing Orders

If you would like to receive books on our improved preselective standing order system, or if you would like to have further information about this service, please contact your area manager or Customer Services Department.

Exhibitions Katie Gilbert Exhibitions Manager Tel: 020 7017 6310 e-mail: katie.gilbert@tandf.co.uk

Reanna Young International Sales Support Coordinator Tel: +44 (0) 20 7017 6114 Fax: +44 (0) 20 7017 6748 e-mail: reanna.young@tandf.co.uk

Caribbean and The West Indies

New Zealand

Middle East and North Africa

Jasmina Basic Area Sales Manager Milton Park Sales Office Tel: +44 (0) 20 7017 6187 Fax: +44 (0) 20 7017 6748 e-mail: jasmina.basic@tandf.co.uk

Macmillan Publishers NZ Ltd Victoria Johnson 6 Ride Way, Albany, Auckland, NZ Tel: +64 9414 0350 Fax: +64 9414 0357 e-mail: vicki@macmillan.co.nz

Australasia

Australia and New Zealand

Jasmina Basic Area Sales Manager – Middle East and Africa Milton Park Sales Office Tel: +44 (0) 20 7017 6187 Fax: +44 (0) 20 7017 6748 e-mail: jasmina.basic@tandf.co.uk Zoe Kaviani IPS (Middle East) Ltd P.O. Box 27533 Dubai, UAE Tel: +971 4 282 8801 Fax: +971 4 282 8804 e-mail: itpme@emirates.net.ae Website: http://www.ipsme.com

Kate Pearce Milton Park Sales Office Tel: +44 (0) 20 7017 6053 Fax: +44 (0) 20 7017 6748 e-mail: kate.pearce@tandf.co.uk

Australia Palgrave Macmillan Level 1, 15-19 Claremont Street, South Yarra Melbourne, Vic 3141, Australia Tel: +61 3 9825 1111 Fax: +61 3 9825 1010 e-mail: palgrave@macmillan.com.au www.palgravemacmillan.com.au

CRC Press and Marcel Dekker only Libraries may wish to order from their local bookseller, Palgrave Macmillan or DA Information Services Pty Ltd 648 Whitehorse Road, Mitcham Victoria, Australia Tel: +61 3 9210 7804 Fax: +61 3 9210 7788 www.dadirect.com.au

Australia Europa Publications (non-exclusive) James Bennett 3 Narabang Way, Belrose, NSW 2085 Australia Tel: +02 9986 7064 Fax: +02 9986 7030 www.bennett.com.au

Rest of Africa Jasmina Basic Area Sales Manager – Middle East and Africa Milton Park Sales Office

12/19/08 9:40:24 AM

Nigeria

Korea

Europe

England and Wales

Chinke Ojiji Publishers Support Services Ltd Plot 2 Adewunmi Estate Oregun Road (Near First Bank Oregun) PO Box 9270, Ikeja, Lagos State Tel: +234 1 774 1073 Fax: +234 1 493 0419 e-mail: chinkeojiji@yahoo.co.uk

Se-Yung Jun ICK (Information & Culture Korea) 473-19 Seokyo-dong, Mapo-ku Seoul, Korea 121-842 Tel: +82 2 3141-4791 Fax: +82 2 3141-7733 e-mail: cs.ick@ick.co.kr

Peter Havinga European Sales Manager A. Hofmanweg 5a, 2031 BH Haarlem The Netherlands Tel: +31 (0) 23 750 5730 Fax: +31 (0) 23 750 5701 Mobile: +31 (0) 6 515 69560 e-mail: peter.havinga@tandf.co.uk

London (East, Northwest, North) and Eastern England

Botswana

For all Taylor & Francis Group imprints please order from our Singapore Sales Office Singapore Sales Office Taylor & Francis Asia Pacific 240 Macpherson Road #08–01 Pines Industrial Building Singapore 348574 Tel: +65 6741 5166 Fax: +65 6742 9356 e-mail: sales@tandf.com.sg

Belgium, The Netherlands, France and Luxembourg

Southern England

South Africa, Namibia, Lesotho and Swaziland Michelle Symington Book Promotions Ltd BMD Office Park, 108 De Waal Road Diep River, 7800 Cape Town South Africa Tel: +27 21 707 5700 General Fax: +27 21 707 5795 Orders Fax: +27 21 707 5794 e-mail: msymingtom@bookpro.co.za

South Asia Ryan Cooper Area Sales Manager Milton Park Sales Office Tel: +44 (0) 20 7017 6113 Fax: +44 (0) 20 7017 6748 e-mail: ryan.cooper@tandf.co.uk

India Taylor & Francis Books India Pvt Ltd. 912 Tolstoy House 15-17, Tolstoy Marg New Delhi 110 001 Tel: +91 (0) 11 2371 2131 +91 (0) 11 2335 1453 Fax: +91 (0) 11 2371 2132 e-mail: tandfindia@airtelbroadband.in

Pakistan M. Anwer Iqbal Book Bird Mian Chambers, 3 Temple Road PO Box 518, Lahore, Pakistan Tel: +92 42 636 7275 Fax: +92 42 636 1370 e-mail: bookbird@brain.net.pk

Sri Lanka Nirosha Saravanapavan e-mail: niroshas@sltnet.lk Mobile: 0094 714 750911

Japan Hans Van Ess Book Sales and Marketing Executive Taylor & Francis Group 7F Koshin Bldg. 2-23-4 Kanda-Jimbocho Chiyoda, Tokyo 101-0051, Japan Tel: +81 (0) 3 5848 7061 Mobile: +81 (0) 80 5426 3552 e-mail: hans.vaness@informa.com United Publishers Services Limited 1-32-5 Higashi-shinagawa Shinagawa-ku, Tokyo 140-0002 Tel: +81 (0) 3 5479 7251 Fax: +81 (0) 3 5479 7307 e-mail: info@ups.co.jp Editorial Office Takahiko Kaneko Edition Synapse Yamaguchi Bldg. 3F 2-8-5 Uchikanda Chiyoda-Ku, Tokyo 101 0047, Japan Tel: +81 (0) 3 5296 9186 Fax: +81 (0) 3 3252 1822 e-mail: edsynapse@nifty.ne.jp

CATBMS_K00164_2009 Cat.indd 143

Hong Kong and Vietnam

Jeffrey Lim, Books Sales Director Singapore Sales Office e-mail: jeffrey.lim@tandf.com.sg

Singapore, Philippines and Indonesia

Francis Chua, Sales Manager Singapore Sales Office e-mail: francis.chua@tandf.com.sg

Thailand

Taylor & Francis Asia Pacific Tel: +66 (2) 6427954-6 ext. 406 Fax: +66 (2) 6427677 Jeffrey Lim, Books Sales Director e-mail: jeffrey.lim@tandf.com.sg Nonglak Sawaithong, Sales Executive e-mail: s.nonglak@tandf.com.sg

Malaysia and Brunei

David Yeong General Manager Taylor & Francis Publishing Services Taylor & Francis Asia Pacific No. 23-2, Jalan PJS 8/18 Dataran Mentari, 46150 Petaling Jaya, Selangor Darul Ehsan, Malaysia Tel: +60 (3) 5630 1361 Fax: +60 (3) 5360 1732 Mobile: +60 (0) 16 331 9912 e-mail: david.yeong@tandf.com.sg

Taiwan

Taylor & Francis Asia Pacific Tel: +886 (2) 2578 6106 ext.125 Fax: +886 (2) 2578 6507 Mobile: +886 (9) 7216 9672 Jeffrey Lim, Books Sales Director e-mail: jeffrey.lim@tandf.com.sg Raymond Hsu, Sales Executive e-mail: raymond.hsu@tandf.com.sg

China

Taylor & Francis Room 903, Resource Building No.151 North Street Zhongguancun, Beijing, China 100080 Tel/Fax: +86 (10) 58876523 Jeffrey Lim, Books Sales Director e-mail: jeffrey.lim@tandf.com.sg Cynthia Ji, Sales & Marketing Executive e-mail: cynthia.ji@tandf.com.sg

Israel and the Palestinian Territories Ryan Cooper Area Sales Manager Milton Park Sales Office Tel: +44 (0) 20 7017 6113 Fax: +44 (0) 20 7017 6748 e-mail: ryan.cooper@tandf.co.uk and Rodney Franklin Franklin’s International PO BOX 3772 7, Tel Aviv 61376, Israel Tel: +972 356 00724 Fax: +972 356 00479 e-mail: rodneyf@netvision.net.il

Liza Walraven Sales Representative A. Hofmanweg 5a, 2031 BH Haarlem The Netherlands Tel: 0031 (0) 23 750 5731 Fax: 0031 (0) 23 750 5701 Mobile: 0031 (0) 6 238 49668 e-mail: liza.walraven@informa.com

Greece Ryan Cooper Area Sales Manager Milton Park Sales Office Tel: +44 (0) 20 7017 6113 Fax: +44 (0) 20 7017 6748 e-mail: ryan.cooper@tandf.co.uk

Nordic Countries Keith Gray Sales Representative Taylor & Francis Group c/o IBC Euroforum Blegdamsvej 104A, 2100 Copenhagen ø Denmark Tel: +45 4195 1428 Mobile: +45 6064 8041 e-mail: keith.gray@informa.com

Nordic Countries Sara Pellijeff Sales Representative Taylor & Francis Group Kungsbroplan 3A, Box 7022 112 27 Stockholm, Sweden Tel: +46 (0)8 440 80 58 Fax: + 46 (0)8 587 662 40 Mobile: +46 (0) 709 965 860 e-mail: sara.pellijeff@informa.com

Germany, Austria and Switzerland Eva Kneissl Area Sales Manager

Daphne Edwards Area Representative Mobile: 07802 536 233 Tel: +44 (0) 20 7017 6259 e-mail: daphne.edwards@tandf.co.uk

Oxfordshire, West Midlands and South Wales John Blake Area Representative Mobile: 07889 263 857 Fax: 01242 228 691 e-mail: john.blake@tandf.co.uk

North and Northwest England Lucy Greaves Area Representative Mobile: 07860 633156 Fax: 01663 746682 e-mail: lucy.greaves@tandf.co.uk

London (EC, SE, SW, W and WC) Charlotte Westgate Area Representative Mobile: 07917 648040 e-mail: charlotte.westgate@tandf.co.uk

Scotland and North of England To be confirmed. Please contact: Nick Perry Area Representative Tel: +44 (0) 20 7017 6132 Fax: +44 (0) 20 7017 6732 e-mail: nick.perry@tandf.co.uk

Ireland and Northern Ireland Conor Graham / Michael Darcy Brookside Publishing Services 2 Brookside, Dundrum Road, Dublin 14 Tel: 00 353 1 298 9937 Fax: 00 353 1 298 7912 e-mail: sales@brookside.ie

(Maternity leave cover for Gabriela Mauch)

Library Supply

Spain, Portugal, and Italy

Nigel Berkeley Library Supply and London Key Accounts Manager Mobile: 07795 968206 e-mail: nigel.berkeley@tandf.co.uk

Mobile: +49 (0) 173905 9469 e-mail: eva.kneissl@informa.com

Philip Veysey Area Sales Manager Príncipe de Vergara 109, 28002 Madrid, Spain Tel: +34 91 700 0688 Fax: +34 91 141 2304 Mobile: +34 68 777 3678 e-mail: philip.veysey@informa.com

Eastern Europe

Sales Agents

Carlson Moilwa Sales Manager Book Promotions/Horizon Books Botswana Gaborone International Finance Park Plot 113-114, Unit 33, Kgale Mews 2, Suite 3 Gaborone, Botswana Tel: + 267 392 4901 Fax: + 267 392 4908 e-mail: crm@vbn.co.bw

East and Southeast Asia

Bob Davis Senior Area Representative Mobile: 07889 263 856 Fax: 01621 819 833 e-mail: bob.davis@tandf.co.uk

143

Online Retailers Rod Abraham Assistant UK Sales Manager Mobile: 07860 380 814 Fax: 01372 273 744 e-mail: rod.abraham@tandf.co.uk

Marek Lewinson (Humanities and Social Sciences) Bohaterewicza 3/45 03-982 Warsaw, Poland Tel/fax: +48 (0) 22 6714819 Mobile: +48 (0) 602 707 037 e-mail: mlewinso@it.com.pl Radek Janousek (Science and Technology) Pod Nouzovem 972/21 197 00 Prague, Czech Republic Tel: +42 (0) 28 658 49888 Mobile: +42 (0) 602294014 e-mail: radek@mareklewinson.com

12/19/08 9:40:25 AM

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