Biomedical Science & Engineering by CRC Press

• • • • •

All netBASE ebook Content on One Platform Pay-per-view Chapters Individual eBook Purchases Annual and Perpetual Subscription Options Available Improved Search and Functionality

Free Trials Available for Libraries

Catalog no. CATBMS

US VERSION

The following subject catalogs are available from CRC Press. You can view them online at the URLs listed or contact your local sales representative for copies.

Taylor & Francis Group

Agricultural and Life Sciences Catalog no. CATAGL • ISBN: 978-0-8493-3864-9 http://issuu.com/CRCPress/docs/annualcat_aglife

Biomedical Science and Engineering

Pioneers in Publishing

Catalog no. CATBMS • ISBN: 978-0-8493-3866-3 http://issuu.com/CRCPress/docs/annualcat_biomed

Business, Management, and Public Administration Catalog no. CATBMP • ISBN: 978-0-8493-9175-0 http://issuu.com/CRCPress/docs/annualcat_bus_pub_admin

Chemistry and Chemical Engineering Catalog no. CATSPC • ISBN: 978-0-8493-3867-0

Grounded in a century-long tradition of publishing excellence, CRC Press Taylor & Francis continues to provide our world with the resources needed to promote human progress and meet the challenges that might stand in the way of that progress. Producers of printed handbooks, textbooks, tutorials, and field guides, as well as e-books, online libraries, and interactive databases, CRC Press is a full service print and electronic publisher committed to recording the accomplishments and supporting the work of the world’s leading practitioners and researchers.

http://issuu.com/CRCPress/docs/annualcat_chem

Civil and Mechanical Engineering Catalog no. CATMCE • ISBN: 978-0-8493-3880-9 http://issuu.com/CRCPress/docs/annualcat_civil_mech_eng

Computer Science and Information Technology Catalog no. CATITB • ISBN: 978-0-8493-3878-6 http://issuu.com/CRCPress/docs/annualcat_compsci_it

Electrical Engineering Catalog no. CATEEC • ISBN: 978-0-8493-3869-4 http://issuu.com/CRCPress/docs/annualcat_elec_eng

Environmental Science and Engineering

It’s no coincidence that many of the issues in today’s headlines read like a list of CRC new releases… from five or even ten years ago. Just as it’s never been a coincidence that the fields of inquiry our authors pursue today often bear the greatest fruit tomorrow. Whether its advancing agriculture yield, improving infrastructure, developing clean and green alternatives, retrofitting industry, reorganizing healthcare, securing our homeland, streamlining public administration, or defining just who we are and where we are going, CRC has the resources and references to turn students into professionals and leaders, researchers into innovators and pioneers. In the classroom, in the laboratory, and out in the field, wherever challenges are being met by research, ingenuity, and determination, you will find those who create and rely on the authoritative content that is the power of CRC Press.

Catalog no. CATEVE • ISBN: 978-0-8493-3874-8 http://issuu.com/CRCPress/docs/annualcat_envsci

Food Science and Nutrition Catalog no. CATFSN • ISBN: 978-0-8493-3876-2 http://issuu.com/CRCPress/docs/annualcat_foodsci

Forensic Science, Law Enforcement, and Homeland Security Catalog no. CATFSC • ISBN: 978-0-8493-3877-9

INVITATION TO AUTHORS If you have an idea for a book or a manuscript in progress relevant to any scientific, technical, or business discipline, CRC Press is interested. Please contact:

John Lavender, Senior VP Publishing 561-994-0555 • john.lavender@taylorandfrancis.com

http://issuu.com/CRCPress/docs/annualcat_forensics

Human Factors and Ergonomics / Industrial Engineering and Manufacturing

To order, visit us online at

Catalog no. CATHFI • ISBN: 978-0-8493-3875-5 http://issuu.com/CRCPress/docs/annualcat_erg_indust_eng

Mathematics and Statistics Catalog no. CATMTS • ISBN: 978-0-8493-3879-3 http://issuu.com/CRCPress/docs/annualcat_math_stats

Nanoscience and Technology / CleanTech Catalog no. CATMSN • ISBN: 978-0-8493-3885-4 http://issuu.com/CRCPress/docs/annualcat_nano_clean_tech

Physics / Materials Science Catalog no. CATPHY • ISBN: 978-0-8493-9176-7 http://issuu.com/CRCPress/docs/annualcat_physics_matsci

Or contact us via the following numbers: North & South America: From inside the US: Phone: 1-800-272-7737 Fax: 1-800-374-3401 Outside the US: Phone: 1-561-994-0555 Fax: 1-561-361-6018 Rest of the World Bookpoint Tel: +44 (0)1235 400400 • Fax: +44 (0)1235 400401

Product Listings Biomedical Science Cell Biology........................................................................................................................................................3 Developmental Biology......................................................................................................................................4 Immunology.......................................................................................................................................................5 Lab Animal Science...........................................................................................................................................6 Microbiology......................................................................................................................................................9 Molecular Biology............................................................................................................................................13 Neuroscience...................................................................................................................................................14 Nutrition Science.............................................................................................................................................23 Protein Science................................................................................................................................................29 Toxicology........................................................................................................................................................31 Biomedical Engineering Biochemistry....................................................................................................................................................33 Biomaterials & Medical Devices......................................................................................................................37 Biomechanics..................................................................................................................................................43 Biomedical Engineering..................................................................................................................................44 Biomedical Imaging.........................................................................................................................................49 Biophysics.......................................................................................................................................................52 Biotechnology..................................................................................................................................................53 Methods & Instrumentation..............................................................................................................................55 Nanobiotechnology.........................................................................................................................................58 Tissue Engineering..........................................................................................................................................60 Pharmacology General References.........................................................................................................................................61 Biopharmaceuticals.........................................................................................................................................62 Drug Delivery...................................................................................................................................................63 Drug Discovery & Development......................................................................................................................64 Pharmaceutical Science..................................................................................................................................67 Pharmacology..................................................................................................................................................68 Pharmacy.........................................................................................................................................................69 Mathematics & Statistics in Biomedicine Bioinformatics..................................................................................................................................................70 Biostatistics......................................................................................................................................................75 Clinical Trials...............................................................................................................................................78 Epidemiology...................................................................................................................................................80 Mathematics for Biology & Medicine...............................................................................................................81 Title Index...............................................................................................................................................................83 Author Index...........................................................................................................................................................88 Sales Agents..........................................................................................................................................................94 Order Form.............................................................................................................................................................96 Ordering Information / Call for Authors........................................................................................ Inside Back Cover

Biomedical Science and Engineering Catalog - 2010

Table of Contents

For more information and a complete list

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Animal Lectins

DNA Damage Recognition

A Functional View

Edited by

Wolfram Siede University of North Texas, Fort Worth, USA

University of Maryland and Biotechnology Institute, College Park, USA

Yoke Wah Kow and Paul W. Doetsch

Lectins are currently of interest in the research community because of their wide variety of properties and potential applications in pharmacology, immunology, and cancer therapy. Identifying lectins and their ligands is the particular focus of intense study. Featuring contributions from recognized experts, Animal Lectins: A Functional View presents up-to-date knowledge of the biological roles of animal lectins, including glycoprotein folding, sorting, and targeting; cell adhesion; embryogenesis; cell-cell interactions and signaling; as well as recognition and effector functions in innate immunity. This book also explores the structural basis of protein-carbohydrate interactions.

Covering an array of topics, this authoritative work summarizes recent developments while providing timely reviews on the molecular mechanisms employed by cells to distinguish between damaged and undamaged sites and stimulate the appropriate repair pathways. Richly illustrated, this guide discusses the theoretical aspects of DNA damage recognition, exploring those that are relevant for various regulatory responses, such as transcriptional regulation or checkpoint arrest. It also details key concepts in the recognition of bulky DNA base damage, reviews the excision repair of non-bulky base damage, and covers short-patch repair and the recognition and repair of single- and double-strand breaks.

Catalog no. 7269, ISBN: 978-0-8493-7269-8 October 2008, 7 x 10, 596 pp. Suggested Price: $199.95 / £127.00

Cellular and Molecular Biology of Metals

Emory University School of Medicine, Atlanta, Georgia, USA

Catalog no. DK3110, ISBN: 978-0-8247-5961-2 September 2005, 7 x 10, 872 pp. Suggested Price: $209.95 / £134.00

Gene and Cell Therapy

Rudolfs K. Zalups

Therapeutic Mechanisms and Strategies, Third Edition

Mercer University School of Medicine, Macon, Georgia, USA

Edited by

D. James Koropatnick

Nancy Smyth Templeton

London Regional Cancer Center, Ontario, Canada

Gradalis Inc., Carrollton, Texas, USA

In recent years, there has been increased understanding of the mechanisms involved in the transport of metal ions into and out of target cells, particularly epithelial cells. In addition, there have been significant advances in the roles of certain metal ions in the conformational changes and function of cellular proteins. This volume explains the role of key biologically relevant divalent metal ions involved in the molecular and cellular biology of various target cell populations. Although it primarily focuses on homeostatic metals such as nickel, zinc, and chromium, the text also discusses a few environmentally relevant toxic divalent cations, including mercury, cadmium, and arsenic.

This latest edition of Gene and Cell Therapy provides comprehensive coverage of all aspects of the tools and state-of-the-art technologies that are currently available in this field. Written by international leaders, this third edition features 12 additional chapters that address such new topics as gene and cell therapies for diabetes and cardiovascular disease, relevant nanotechnologies, siRNA therapeutics, dendrimers, clinical trials, human embryonic stem cell research, tissue engineering, and novel polymers. All chapters in the text have been substantially updated and revised to reflect the latest information available in the field.

Catalog no. 59971, ISBN: 978-1-4200-5997-7 April 2010, 7 x 10, 496 pp. Suggested Price: $199.95 / £127.00

Catalog no. 8768, ISBN: 978-0-8493-8768-5 October 2008, 8-1/2 x 11, 1120 pp. Suggested Price: $229.95 / £146.00

Dietary Modulation of Cell Signaling Pathways Edited by

Young-Joon Surh, Zigang Dong, Enrique Cadenas, and Lester Packer Series: Oxidative Stress and Disease, 25

A comprehensive review of recent research findings, this book focuses on nutrientgene interactions and the intracellular signaling network. Comprehensively covering dietary modulation of cell signaling, leading experts address the dietary modulation of particular gene expression systems. The book highlights the underlying molecular and cellular mechanisms that involve upstream signaling molecules, such as kinases and transcription factors in the context of their therapeutic potential. It describes nutrients’ actions on the activation of an antioxidant and inflammatory transcription factor and the induction of their target gene expression. Catalog no. 8148, ISBN: 978-0-8493-8148-5 September 2008, 6 x 9, 504 pp. Suggested Price: $149.95 / £95.00

Cell Biology

Gerardo R. Vasta and Hafiz Ahmed

Lipid-Mediated Signaling Eric J. Murphy and Thad A. Rosenberger University of North Dakota, Grand Forks, USA Methods in Signal Transduction Series

Reviewing the most current research in this rapidly expanding yet resourcelimited field, Lipid-Mediated Signaling provides a much needed examination of a decade’s worth of research tying pathologic disorders such as cancer and autoimmunity problems to aberrant or deregulated signal transduction processes. It considers particular cells, tissues, and organ systems, and discusses recent efforts to identify the various signaling proteins that govern their behavior. The book divides its material under five topics: fatty acid metabolism, eicosanoid formation, acyl hydrolase activity, phospholipids and nuclear signaling, and gene expression. It includes contributions from a number of pioneering experts in this emerging field. Catalog no. 8141, ISBN: 978-0-8493-8141-6 February 2010, 6-1/8 x 9-1/4, 456 pp. Suggested Price: $159.95 / £99.00

For more information and a complete list Osmotic and Ionic Regulation Cells and Animals Edited by

David H. Evans

Cell Biology / Developmental Biology

University of Florida, Gainesville, USA

Osmotic and Ionic Regulation: Cells and Animals not only fills a gap in the literature, but also delineates the new approaches and findings that define the field. Providing the first comprehensive summary of fundamentally important mechanisms of ionic and osmotic regulation in 40 years, it ties new findings to the older work of W.T.W. Potts and Gwyneth Parry. Written by renowned experts, the book provides background in a broad range of disciplines such as zoology, evolutionary biology, physiology, ichthyology, marine biology, entomology, herpetology, avian biology, human nephrology, and pharmacology. Catalog no. 8030, ISBN: 978-0-8493-8030-3 November 2008, 7 x 10, 606 pp. Suggested Price: $129.95 / £82.00

Signaling by Toll-Like Receptors Edited by

Gregory W. Konat West Virginia University, Morgantown, USA Methods in Signal Transduction Series

The recent discovery of an ancient family of toll-like receptors (TLRs) in the immune system has substantially enhanced the potential for a variety of therapies both for failing immune systems, which leave the body open to infection, or over-active ones, which can lead to chronic inflammation. Signaling by TollLike Receptors provides a comprehensive review of important techniques in molecular biology, cell biology, biochemistry, genetics, and immunology, and their critical application to the study of toll-like receptor structure, biological function, and the intracellular signaling triggered by these receptors, as well as the high promise for uncovering effective pharmaceutical targets. Catalog no. 43188, ISBN: 978-1-4200-4318-1 June 2008, 6-1/8 x 9-1/4, 224 pp. Suggested Price: $149.95 / £95.00

Clinical Embryology A Color Atlas and Text Murray Brookes University of London, UK

Anthony Zietman Massachusetts General Hospital, Salem, USA

Clinical Embryology: A Color Atlas and Text unravels and illuminates the complex process of both normal and abnormal prenatal human developments. Vivid color drawings and photographs, many in three dimensions, clarify difficult concepts and bring contemporary clinical examples to life. Each section of the atlas includes pertinent case reports, clinical photographs, radiologic studies, and examples from the pathology lab that emphasize the importance of embryology across the field of medicine. Catalog no. 1255, ISBN: 978-0-8493-1255-7 August 1998, 8-1/2 x 11, 352 pp. Suggested Price: $57.95 / £36.99

Atlas of Human Central Nervous System Development Five-Volume Set Shirley A. Bayer and Joseph Altman Indianapolis, Indiana, USA

Available now as a set, this award-winning series provides a complete record of the development of the human central nervous system from spinal cord gestation through the third trimester. The contents are organized by coronal, sagittal, and horizontal planes of sectioning, ensuring pictorial representation of nearly every structure in the developing brain. Each volume provides two-page spreads containing high resolution black and white images on one side and ghost images on the other with unabbreviated labels that clearly identify each structure. The final volume summarizes major events of CNS development and offers a theoretical account of the morphogenetic processes involved.

Order the set and save!

Five-Volume Set

Catalog no. 68008, ISBN: 978-1-4200-6800-9 July 2007 Suggested Price: $749.00 / £477.00

Also available individually

The Spinal Cord from Gestational Week 4 to the 4th Postnatal Month Catalog no. 1420, ISBN: 978-0-8493-1420-9 May 2002, 8-1/2 x 11, 256 pp. Suggested Price: $219.95 / £140.00

The Human Brain During the Early First Trimester Catalog no. 1424, ISBN: 978-0-8493-1424-7 July 1007, 8-1/2 x 11, 536 pp. Suggested Price: $169.95 / £108.00

The Human Brain During the Late First Trimester Catalog no. 1423, ISBN: 978-0-8493-1423-0 2006, 8-1/2 x 11, 592 pp. Suggested Price: $189.95 / £121.00

The Human Brain During the Second Trimester Catalog no. 1422, ISBN: 978-0-8493-1422-3 May 2005, 8-1/2 x 11, 384 pp. Suggested Price: $179.95 / £114.00

The Human Brain During the Third Trimester Catalog no. 1421, ISBN: 978-0-8493-1421-6 December 2003, 412x285, 392 pp. Suggested Price: $199.95 / £127.00

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Textbook

From the Laboratory to the Field

The Physiology of Fishes

Edited by

Third Edition

C.G. Nicholas Mascie-Taylor

Edited by

University of Cambridge, UK

Akira Yasukouchi Kyushu University, Fukuoka, Japan

Stanley Ulijaszek University of Oxford, UK Series: Society for the Study of Human Biology, 49

Unique in its approach, this work updates our understanding of human variation by employing both laboratory and field perspectives. Written by a team of scientists representing four continents, it reviews the way we examine and analyze human variation with special reference to genetics, growth and development, and physiology. In describing the main factors influencing human variation, it delves into environmental plasticity, lifestyle, and heritability of characteristics. A significant part of the focus is on the methodology and analytical techniques, detailing field and laboratory approaches and looking at how the two perspectives complement each other. Catalog no. 84712, ISBN: 978-1-4200-8471-9 March 2010, 6-1/8 x 9-1/4, 296 pp. Suggested Price: $99.95 / £63.99

David H. Evans University of Florida, Gainesville, USA

James B. Claiborne Georgia Southern University, Statesboro, USA Series: Marine Biology

Developmental Biology / Immunology

Human Variation

With the genomic revolution and a heightened understanding of molecular biology, we now have the tools and the knowledge to apply a fresh approach to the study of fishes. Consequently, The Physiology of Fishes, Third Edition is not merely another updating, but an entire reworking of the original. In addition to chapters on gas transport, temperature physiology, and stress, as well as one dedicated to functional genomics, readers will discover that many of the contributors approach their material with a contemporary molecular perspective. Catalog no. 2022, ISBN: 978-0-8493-2022-4 December 2005, 7 x 10, 616 pp. Suggested Price: $119.95 / £76.99

Medicine and Evolution Current Applications, Future Prospects Edited by

Sarah Elton and Paul O’Higgins Hull York Medical School, University of York, UK Series: Society for the Study of Human Biology

Atlas of Immunology Third Edition Julius M. Cruse and Robert E. Lewis University of Mississippi Medical Center, Jackson, USA

Highlighting exciting areas of research into the evolutionary basis of health and disease, this book employs a multidisciplinary perspective to emphasize practical applications and address how evolutionary medicine may inform clinical practice as well as medical education. Presenting new data and weighing relevant evidence, the book introduces novel viewpoints on nutrition, diabetes, fertility, pediatrics, immune response, and psychiatry. It discusses when evolutionary viewpoints might and might not be useful and conducts critical debates on controversial areas such as race-based pharmaceuticals.

With more than 1,300 figures, line drawings, and photographs, the Atlas of Immunology clearly demonstrates that “a picture is worth a thousand words.” Each entry of this third edition has been revised to reflect recent advances in scientific knowledge based on current research. A new chapter on Immunophenotyping of Hematopoietic Malignancies has been added and the History of Immunology chapter has been expanded, detailing pivotal research developments. The subject matter of the book ranges from photographs of historical figures to molecular structures of recently characterized cytokines, major histocompatibility complex molecules, immunoglobins, and molecules of related interest.

Catalog no. 51342, ISBN: 978-1-4200-5134-6 June 2008, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $129.95 / £82.00

Catalog no. K10141, ISBN: 978-1-4398-0268-7 April 2010, 8-1/2 x 11, 856 pp. Suggested Price: $119.95 / £76.99

Methods in Reproductive Aquaculture Marine and Freshwater Species

Chemical and Biological Properties of Food Allergens

Edited by

Elsa Cabrita

Lucjan Jedrychowski

University of Algarve, Faro, Portugal

Vanesa Robles and Paz Herráez University of Leon, Spain Series: Marine Biology

Institute of Animal Reproduction & Food Research, Olsztyn, Poland

Harry J. Wichers Wageningen University, The Netherlands Series: Chemical & Functional Properties of Food Components, 12

Providing an overview of available techniques for fish farmers and researchers, Methods in Reproductive Aquaculture addresses ways to improve depleted stocks of endangered fish and other species. Written by international experts, this practical guide provides a highly readable review of gamete extraction, sperm collection, and egg stripping in different species. It then focuses on sperm and egg quality characteristics before presenting information on the materials and facilities required for gamete preparation and freeze-thawing procedures. It includes the first practical guidance on cryopreservation as a technique for gamete management. A final section reviews important aspects of gamete handling before, during, and after fertilization and incubation.

The problem of food allergies is becoming a significant sociological and economic issue. Addressing chemical, analytical, and medical aspects, Chemical and Biological Properties of Food Allergens explains the basic mechanisms of allergenic reactions in humans, the molecular background of these mechanisms, and the problems of food tolerance and intolerance. Evaluating the current research literature in a concise and user-friendly format, this book characterizes basic groups of food allergens as well as commonly occurring allergens and describes various technological and biotechnological methods of lowering the immunoreactive and allergenic properties of foods.

Catalog no. 8053, ISBN: 978-0-8493-8053-2 August 2008, 6-1/8 x 9-1/4, 568 pp. Suggested Price: $109.95 / £69.99

Catalog no. 5855X, ISBN: 978-1-4200-5855-0 September 2009, 6-1/8 x 9-1/4, 447 pp. Suggested Price: $159.95 / £97.00

For more information and a complete list Handbook of Human Immunology Second Edition Edited by

Maurice R.G. O’Gorman

A Practical Handbook for Toxicologists and Biomedical Researchers, Second Edition

The Children’s Memorial Hospital, Chicago, Illinois, USA

Edited by

Albert D. Donnenberg

G.O. Evans

Immunology / Lab Animal Science

Hillman Cancer Center, Pittsburgh, Pennsylvania, USA

A. George Owen and Company, UK

Since the publication of the first edition of the Handbook of Human Immunology, major scientific achievements have elucidated our understanding of the complexities of the human immune system. This second edition compiles the major breakthroughs of the past decade including dramatic increases in the number of recognized “clusters of differentiation” on the surface of leukocytes and associated cells, establishment of a chemokine receptor nomenclature system, and discovery of more than 30 “lymphokines.” The text emphasizes clinically relevant immunological parameters, and clarifies the basic principles underlying immune system assays.

Assembling information widely dispersed throughout the literature, the second edition of this work focuses on information of relevance to experimental toxicology as separate from human medicine. It presents background information on the selection and application of biochemical tests in safety assessment studies. In addition to chapters which discuss the assessment of toxicity in specific organs, such as the liver, kidney and thyroid, the book also covers pre-analytical variables, regulatory requirements, and statistical approaches, while highlighting some of the major differences between humans and various laboratory animals.

Catalog no. 1984, ISBN: 978-0-8493-1984-6 February 2008, 6-1/8 x 9-1/4, 640 pp. Suggested Price: $189.95 / £121.00

Illustrated Dictionary of Immunology

Animal Clinical Chemistry

Catalog no. 80113, ISBN: 978-1-4200-8011-7 April 2009, 6-1/8 x 9-1/4, 368 pp. Suggested Price: $79.95 / £48.99 Also Available in Soft Cover

Animal Hematotoxicology

Third Edition

A Practical Guide for Toxicologists and Biomedical Researchers

Julius M. Cruse and Robert E. Lewis

G.O. Evans

University of Mississippi Medical Center, Jackson, USA

A. George Owen and Company, UK

Designed for both immunologists and those from other fields seeking a working understanding of immunology, this substantially revised and expanded new edition of the bestselling Illustrated Dictionary of Immunology strengthens its position as the leading general reference on the essential concepts of immunology. Written by two of the most respected scientists in the field, this edition features a huge number of illustrations, while also adding additional computer-generated figures, line drawings, and photographs that illustrate critical aspects of immunology. The third edition also includes terms from various subspecialties, ranging from molecular immunology to transplantation.

Hematology data from in vivo toxicology studies remains one of the most predictive measures for human risk, as the same measurements made in preclinical toxicology studies can be made in early clinical trials. Covering the three main blood cell types, this work is designed to clarify topics for new entrants in laboratory animal hematology and toxicology. An entire chapter is devoted to immunotoxicology. The text also addresses pre-analytical and analytical variables, as these tend to be more difficult to control in animal studies. Information has been collated from published papers, textbooks and unpublished data: Key references are provided to encourage further study.

Catalog no. 7987, ISBN: 978-0-8493-7987-1 April 2009, 8-1/2 x 11, 816 pp. Suggested Price: $99.95 / £60.99

Catalog no. 80091, ISBN: 978-1-4200-8009-4 July 2008, 6-1/8 x 9-1/4, 224 pp. Suggested Price: $79.95 / £49.99

Nucleic Acids in Innate Immunity

Biodefense

Edited by

Ken J. Ishii and Shizuo Akira

James R. Swearengen

Research Methodology and Animal Models

Osaka University, Japan

USAMRIID, Fort Detrick, Maryland, USA

Providing insight into new areas of immunology, this book explains the roles of nucleic acids in immunity, describing the mechanism of discrimination based on pattern-recognition receptors (PRRs). It explores how these PRRs recognize and respond to pathogen-associated molecular patterns (PAMPs) by activating specific signaling pathways. It focuses on the therapeutic applications of immunomodulatory DNA to prevent or treat infectious diseases, allergic disorders, and cancer and addresses how the immune system discriminates self and non-self RNA. Contributions also review recent advances in understanding what elements within DNA or RNA activate the innate immune recognition of nucleic acids.

To ensure that efforts to improve our biodefensive capabilities continue in an efficient manner, this volume presents a thorough review of pertinent research, encouraging researchers to leverage relevant results, rather than duplicate them. Thus, scientists will be able to make the best use of resources and avoid unnecessary experimentation. With contributions from those who have developed the animal models presented, this book examines bacterial, viral, and toxic agents considered to pose the greatest threat. Each section on a specific agent provides background, followed by a description of those animal models employed, and a discussion of how the findings translate to human impact.

Catalog no. 68253, ISBN: 978-1-4200-6825-2 May 2008, 6-1/8 x 9-1/4, 304 pp. Suggested Price: $159.95 / £99.00

Catalog no. 2836, ISBN: 978-0-8493-2836-7 November 2005, 6-1/8 x 9-1/4, 352 pp. Suggested Price: $164.95 / £105.00

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

David M. Jacobowitz

Second Edition Volume I, II, and III

Laboratory of Clinical Science, NIH, Bethesda, Maryland, USA

Edited by

Louise C. Abbott

Jann Hau

Texas A & M University, College Station, USA

With more than 500 full-color coronal sections, Chemoarchitectonic Atlas of the Developing Mouse Brain provides complete spatial and temporal coverage of the developing brain. Both posterior and anterior regions are included, and for each of the coronal sections, sagittal sections are provided. This allows for orientation of each coronal section with reference to the whole brain. The temporal coverage of the Atlas includes four gestational ages plus the newborn stage, representing the full period during which neuronal differentiation occurs in the brain. Catalog no. 2667, ISBN: 978-0-8493-2667-7 December 1997, 8-1/2 x 11, 304 pp. Suggested Price: $389.95 / £248.00

Experimental Surgical Models in the Laboratory Rat Edited by

Alfredo Rigalli and Veronica Di Loreto Rosario National University, Argentina

The design of an adequate surgical model, like the choice of the animal model itself, is extremely important for obtaining reliable valuable data. Written for biomedical researchers, this manual on the surgery of the rat summarizes a series of techniques that have been applied at the Bone Biology Laboratories of the School of Medicine at Rosario National University. Stopping short of an exhaustive analysis of the techniques, the manual describes the basis of each surgical technique, the necessary materials including catheters, precautions to consider, the methodology to apply, and the possible results to be obtained. The descriptions of each technique appear with diagrams and pictures. Catalog no. 93266, ISBN: 978-1-4200-9326-1 May 2009, 7 x 10, 232 pp. Suggested Price: $139.95 / £85.00

Histologic Basis of Mouse Endocrine System Development A Comparative Analysis

University of Copenhagen & Rigshhospitalet, Denmark

Gerald L. Van Hoosier, Jr. University of Washington, Seattle, USA

Now in its second edition, these three volumes offer contributions from eminent scientists who share knowledge gained through their own hands-on research. Taken as a whole, it provides a thorough overview on the use of the laboratory animal for veterinary and biomedical research. However, its in-depth chapters can also serve as stand-alone reference material for addressing specific concerns. Essential Principles and Practices, Volume I provides detailed information about laboratory animal genetics, diseases, health monitoring, nutrition, and environmental impact on animal experiments. It covers procedures in genetic engineering, surgical techniques, the treatment of pain and suffering in laboratory animals, and alternatives to animal experimentation, such as the use of isolated organs, cell cultures, and computer simulations. Volume I, Catalog no. 1086, ISBN: 978-0-8493-1086-7 October 2002, 7 x 10, 566 pp. Suggested Price: $154.95 / £98.00 Animal Models, Volume II details criteria used to choose species and strains. It addresses the development and application of models for research in skeletal disease, xenotransplantation, dental disorders, and psychological testing. It also covers spontaneous genetic mutants and genetically modified animal models. Volume II, Catalog no. 1084, ISBN: 978-0-8493-1084-3 2002, 7 x 10, 280 pp. Suggested Price: $114.95 / £72.99 Animal Models, Volume III covers the use of laboratory animals as models in a range of biomedical research disciplines. Individual chapters focus on AIDS, biodefense, and human behavior. Volume III, Catalog no. 1893, ISBN: 978-0-8493-1893-1 2005, 7 x 10, 320 pp. Suggested Price: $114.95 / £72.99

Infectious Diseases and Pathology of Reptiles Color Atlas and Text Edited by

Elliott Jacobson

Matthew Kaufman, Alexander Yu. Nikitin, and John P. Sundberg

University of Florida College of Veterinary Medicine, Gainesville, USA

Series: Research Methods For Mutant Mice

Featuring 1,200 high-quality, color photos of normal anatomy and histology, as well as gross, light, and electron microscopic images of pathogens and diseases, this exceptionally comprehensive atlas provides definitive information on every known infectious disease affecting reptiles. Beginning with a thorough review of reptile biology, anatomy, and histology, leading authorities then addresses specific topics such as immunology, circulating inflammatory cells, necropsy techniques, pathogen identification and isolation, molecular diagnosis, and serodiagnostics. The atlas also catalogs specific pathologies due to viruses, bacteria, fungi, and parasites. Included are numerous never-before published electron microscope findings of reptile lesions.

More than 3,000 mutant mice strains have been created through genetic manipulation, and while many molecular techniques are straightforward, analysis of anatomic changes can be a challenge for even the best pathologist. To keep up with current interest in the endocrine system, this volume provides researchers with both a survey and a guide concerning use of the mutant mouse in histological studies of various glands. Applying color throughout, this atlas illustrates the similarities and differences between the mouse endocrine system and that of other species, including humans. It includes approximately 50 high magnification color plates and a variety of sectioned embryos post conception. Catalog no. 88181, ISBN: 978-1-4200-8818-2 October 2009, 7 x 10, 240 pp. Suggested Price: $149.95 / £95.00

Lab Animal Science

Chemoarchitectonic Atlas of the Developing Mouse Brain

Handbook of Laboratory Animal Science

Catalog no. 2321, ISBN: 978-0-8493-2321-8 April 2007, 8-1/2 x 11, 736 pp. Suggested Price: $199.95 / £127.00

For more information and a complete list

Laboratory Animal Pocket Reference Series Eleven-Volume Set Edited by Mark

A. Suckow, University of Notre Dame, Indiana, USA

Lab Animal Science

The Laboratory Animal Pocket Reference Series was created to assist those who work with laboratory animals, enabling them to provide the most humane, responsible care possible. These bestselling books are compact and lay flat when opened, making them perfect for bench-top use. Each one includes important husbandry, care, veterinarian, and management information with regard to the titled species along with experimental methodology and resources.

Save on the set!

Mark A. Suckow University of Notre Dame, Indiana, USA

Peggy Danneman The Jackson Laboratory, Bar Harbor, Maine, USA

Cory Brayton John Hopkins University School of Medicine, Baltimore, Maryl Series: Laboratory Animal Pocket Reference, 8

Catalog no. 0322, ISBN: 978-0-8493-0322-7 December 2000, 6-1/8 x 9-1/4, 184 pp., Soft Cover Suggested Price: $52.95 / £33.99

Catalog no. 2560, ISBN: 978-0-8493-2560-1 March 2000, 8-1/2 x 11, Suggested Price: $525.00 / £334.00

The Laboratory Rat

The Laboratory Cat

National University of Singapore

Brent J. Martin Medical College of Ohio, Toledo, USA

Catalog no. 2567, ISBN: 978-0-8493-2567-0 November 1997, 6-1/8 x 9-1/4, 160 pp., Soft Cover Suggested Price: $52.95 / £33.99

The Laboratory Guinea Pig Lizabeth A. Terril-Robb Purdue University, West Lafayette, Indiana, USA

Donna J. Clemons Covance Laboratories Inc., Madison, Wisconsin, USA

Catalog no. 2564, ISBN: 978-0-8493-2564-9 November 1997, 6-1/8 x 9-1/4, 192 pp., Soft Cover Suggested Price: $52.95 / £33.99

The Laboratory Hamster and Gerbil 8

The Laboratory Mouse

Karl J. Field Bristol Myers Veterinary Sciences, Flemington, New Jersey, USA

Amber L. Sibold Consultant, East Hanover, New Jersey, USA

Catalog no. 2566, ISBN: 978-0-8493-2566-3 December 1998, 6-1/8 x 9-1/4, 168 pp., Soft Cover Suggested Price: $52.95 / £33.99

The Laboratory Swine Second Edition Peter J. A. Bollen University of Southern Denmark

Axel K. Hansen Agriculture University, Frederiksberg, Denmark

Aage Kristian Olsen Alstrup Arhus Kommunehospital, Denmark

Patrick E. Sharp Marie C. La Regina Washington University, St. Louis, Missouri, USA Series: Laboratory Animal Pocket Reference, 4

Catalog no. 2565, ISBN: 978-0-8493-2565-6 April 1998, 6-1/8 x 9-1/4, 240 pp., Soft Cover Suggested Price: $52.95 / £33.99

The Laboratory Rabbit Second Edition Mark A. Suckow and Valerie Schroeder The University of Notre Dame, Indiana, USA

Catalog no. 91050, ISBN: 978-1-4200-9105-2 April 2010, 6-1/8 x 9-1/4, 144 pp., Soft Cover Suggested Price: $59.95 / £38.99

The Laboratory Small Ruminant Matthew J. Allen SUNY Health Science Center, Syracuse, New York, USA

Gary L. Borkowski Consultant, Saint Louis, Missouri, USA

Catalog no. 2568, ISBN: 978-0-8493-2568-7 March 1999, 6-1/8 x 9-1/4, 176 pp., Soft Cover Suggested Price: $52.95 / £33.99

The Laboratory Nonhuman Primate Jeffrey D. Fortman, Terry A. Hewett, and B. Taylor Bennett University of Illinois, Chicago, USA Series: Laboratory Animal Pocket Reference, 9

Catalog no. 2562, ISBN: 978-0-8493-2562-5 September 2001, 6-1/8 x 9-1/4, 288 pp., Soft Cover Suggested Price: $57.95 / £36.99

Catalog no. K10783, ISBN: 978-1-4398-1528-1 February 2010, 6-1/8 x 9-1/4, 132 pp., Soft Cover Suggested Price: $59.95 / £38.99

New!

The Laboratory Canine

Sherril L. Green

Garrett Field

Catalog no. 91093, ISBN: 978-1-4200-9109-0 November 2009, 6-1/8 x 9-1/4, 180 pp., Soft Cover Suggested Price: $59.95 / £38.99

Eli Lilly and Company, Indianapolis, Indiana, USA

Todd A. Jackson Bristol-Myers Squibb, Evansville, Indiana, USA

Catalog no. 2893, ISBN: 978-0-8493-2893-0 October 2006, 6-1/8 x 9-1/4, 184 pp., Soft Cover Suggested Price: $52.95 / £33.99

The Laboratory Xenopus sp. Stanford University, California, USA

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Managing the Laboratory Animal Facility

Applied Biomedical Microbiology

Second Edition

Edited by

Jerald Silverman

Daryl S. Paulson

University of Massachusetts Medical School, Worcester, USA

BioSciences Laboratories, Inc., Bozeman, Montana, USA

A launching pad to providing high-quality management of laboratory animal facilities in a financially sound manner, this guide enables a basic understanding of management and leadership concepts in laboratory animal science. While retaining the focus of its predecessor, this edition contains more than 100 additional pages of expanded material. It includes a chapter on leadership, a greatly expanded chapter on the management of human resources, an appendix on productivity goals and measurements, and a revised appendix on how to calculate per diem rates.

Biofilms now account for over 80 percent of microbial infections in the body, Applied Biomedical Microbiology: A Biofilms Approach presents an in-depth discussion of medically challenging biofilms, written from a variety of perspectives by leading researchers. It provides a solid foundation in the basic microbiology of biofilms and then goes on to discuss those biofilms associated with medical devices, catheters, and dental unit water lines as well as those that impact cardiovascular medicine, the gastrointestinal system, periodontal disease, and chronic wounds. A final chapter addresses a variety of methods used to investigate biofilms.

Catalog no. 55569, ISBN: 978-1-4200-5556-6 July 2008, 6-1/8 x 9-1/4, 328 pp. Suggested Price: $79.95 / £49.99

Swine in the Laboratory Surgery, Anesthesia, Imaging, and Experimental Techniques, Second Edition Edited by

M. Michael Swindle

Catalog no. 7569, ISBN: 978-0-8493-7569-9 October 2009, 6-1/8 x 9-1/4, 176 pp. Suggested Price: $129.95 / £82.00

Bacterial Resistance to Antimicrobials Second Edition Edited by

Richard G. Wax, Kim Lewis, Abigail Salyers, and Harry Taber

Medical University of South Carolina, Charleston, USA

Wadsworth Center, Albany, New York, USA

To diminish the learning curve associated with using swine as models, this book provides practical technical information for the use of swine in biomedical research. It focuses on models produced by surgical and other invasive procedures, supplying the basic principles for performing experiments with an organ or system of interest. This edition contains never-before-published images, new chapters on toxicology and radiobiology, updated sections on anesthesia and perioperative care, and expanded details on anatomy and endoscopy. It also includes an accompanying DVD with 3-D, color images.

Blending scientific and practical approaches, this second edition examines the social, economic, and medical issues related to the growing problem of bacterial resistance. It outlines the forces that contributed to the abuse of antibiotics and precipitated the current crisis. The core chapters describe the latest findings in bacterial ecology, the biomechanics of resistance and susceptibility, and the latest avenues to develop new antibiotics that are themselves resistant to resistance mechanisms. Examining the success and limitations of complimentary approaches, the book pulls together all of the information on resistance mechanisms in different groups of bacteria to help future efforts.

Catalog no. 9278, ISBN: 978-0-8493-9278-8 March 2007, 7 x 10, 496 pp. Suggested Price: $154.95 / £98.00

Advanced Quantitative Microbiology for Foods and Biosystems

Catalog no. 9190, ISBN: 978-0-8493-9190-3 December 2007, 6-1/8 x 9-1/4, 448 pp. Suggested Price: $185.95 / £121.00

Carbohydrate-Active Enzymes

Models for Predicting Growth and Inactivation

Structure, Function and Applications

Micha Peleg

Edited by

University of Massachusetts, Amherst, USA Series: Contemporary Food Science, 18

Kwan-Hwa Park

Presenting a novel view of the quantitative modeling of microbial growth and inactivation patterns in food, water and biosystems, this book describes new models to predict microbial growth and survival under a variety of conditions. The author provides coverage of both traditional and alternative models of thermal and non-thermal inactivation. Included are chapters on microbial dose response, interpretation of irregular count records and on estimating the frequencies of future outbursts. The book features numerous illustrations, equations, tables and figures to clarify material.

This comprehensive collection, the proceedings of an international symposium held in Seoul, Korea, summarizes some of the most important research in the field of carbohydrate-active enzymes. Edited by a leading expert in the field, entries range from enzyme classification and structural elucidation to applications of enzymes in food processing and other industries. Part One focuses on structurefunction relationships of carbohydrate-active enzymes. The second section discusses functions and applications of carbohydrate-active enzymes, such as enzymes for grain processing and glycosidases and their mutants as useful tools for glycoside synthesis.

Catalog no. 3645, ISBN: 978-0-8493-3645-4 April 2006, 6 x 9, 456 pp. Suggested Price: $175.95 / £111.00

Lab Animal Science / Microbiology

A Biofilms Approach

Pusan National University, Korea and Seoul National University

Catalog no. N10036, ISBN: 978-1-4398-0158-1 October 2008, 6 x 9, 312 pp. Suggested Price: $239.95 / £125.00

For more information and a complete list Foodborne Pathogens Cleanroom Microbiology for the Non-Microbiologist David M. Carlberg

Edited by

Clive de W. Blackburn and Peter J. McClure

Microbiology

Huntington Beach, California, USA

Unilever Colworth, UK

This second edition of a bestseller explains the consequences of microbiological contamination, what contamination is all about, how microorganisms grow, and how they can be controlled. The book introduces the types, sources, control, and elimination of organisms encountered in the manufacture of sterile products as well as the applications for bacterial detection, avoidance of contamination, and cleanroom design considerations. The author has rewritten the text according to updated standards and practices for controlling microbial contamination in cleanrooms.

As outbreaks of foodborne disease continue to rise, the effective identification and control of pathogens becomes ever more important for the food industry. With its distinguished international team of contributors, Foodborne Pathogens presents an authoritative and practical guide to effective control measures and how they can be applied to individual pathogens. The book covers general techniques in assessing and managing bacterial hazards, modeling pathogen behavior and carrying out a risk assessment, good management practices, hygienic process design and operation, and more. The book is an essential guide to successful pathogen control in the food industry.

Catalog no. PH1996, ISBN: 978-0-8493-1996-9 October 2004, 6-1/8 x 9-1/4, 216 pp. Suggested Price: $175.95 / £111.00

Cryptosporidium and Cryptosporidiosis Second Edition

Catalog no. N10071, ISBN: 978-1-4398-0768-2 July 2009, 6 x 9, 521 pp. Suggested Price: $359.95 / £225.00

Textbook

Fundamental Food Microbiology

Edited by

Fourth Edition

Ronald Fayer

Bibek Ray

United States Department of Agriculture, Beltsville, Maryland

University of Wyoming (Emeritus), Laramie, USA

Lihua Xiao

Arun Bhunia

National Center for Disease Control & Prevention, Atlanta, Georgia, USA

Hazards, Risk Analysis and Control, Second Edition

This latest edition of a bestseller covers every aspect of these adaptable parasites, including molecular biology, genetic regulation, and comparative genomics. It highlights practical considerations such as outbreaks, transmission dynamics, disinfection, and disease presentation in reptiles, birds, and mammals. It also discusses the treatment of drinking water and wastewater, details governmental regulations, examines host immune responses, and explores the use of structural proteins and metabolic pathways as potential drug targets. The final chapters define appropriate animal models for parasite propagation and research and describe the cells and media most useful for in vitro techniques. Catalog no. 52268, ISBN: 978-1-4200-5226-8 December 2007, 7 x 10, 576 pp. Suggested Price: $129.95 / £82.00

Defensive Mutualism in Microbial Symbiosis

Purdue University, West Lafayette, Indiana, USA

Maintaining the high standard set by the previous bestselling editions, this fourth edition continues to present the most up-to-date information in this rapidly growing and highly dynamic field. Revised and expanded to reflect recent advances, it includes many emerging pathogens as well as descriptions of the mechanism of pathogenesis. A chapter on detection methods appears in this edition with evaluations of advanced rapid detection techniques using biosensors and nanotechnology. Along with many more easy-to-follow figures and illustrations, each chapter includes an introduction, conclusion, references, and questions. Catalog no. 7529, ISBN: 978-0-8493-7529-3 October 2007, 7 x 10, 536 pp. Suggested Price: $69.95 / £44.99

Fungal Pathogenesis in Plants and Crops

Edited by

Molecular Biology and Host Defense Mechanisms, Second Edition

James F. White, Jr. and Monica S. Torres

P. Vidhyasekaran

Rutgers University, New Brunswick, NJ, USA Series: Mycology, 27

Tamil Nadu Agricultural University, Coimbatore, India Series: Books in Soils, Plants, and the Environment, 58

Defensive Mutualism in Microbial Symbiosis includes basic ecology and biological information on defensive mutualisms, explores how they function, and evaluates how they have evolved. It also looks at the implications of symbiosis defensive compounds as a new frontier in bioexploration for drug and natural product discovery. The book expands the concept of defensive mutualisms to evaluate defense against environmental abiotic and biotic stresses. Addressing the topic of defensive mutualisms in microbial symbiosis across this wide spectrum, it includes chapters on defensive mutualistic associations involving multiple kingdoms of organisms in terrestrial and aquatic ecosystems.

The second edition of the widely acclaimed Fungal Pathogenesis in Plants and Crops covers the fungal infection process, molecular host-defense mechanisms, and events leading to the suppression of these defense mechanisms by fungal pathogens. This second edition features chapters on disease resistance and susceptibility genes in signal perception and emission, and cell death signaling in disease susceptibility and resistance. This text also includes additional material on phytoalexins, toxins, signal perception and transduction in fungal pathogenesis, and 17 families of pathogenesis-related proteins.

Catalog no. 69314, ISBN: 978-1-4200-6931-0 May 2009, 7 x 10, 430 pp. Suggested Price: $139.95 / £85.00

Catalog no. DK9867, ISBN: 978-0-8493-9867-4 August 2007, 7 x 10, 536 pp. Suggested Price: $175.95 / £111.00

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Insect Symbiosis Fifth Edition Henry Lutz Ehrlich Rensselaer Polytechnic Institute, Troy, New York, USA

Dianne K. Newman

Volume 3 Edited by

Kostas Bourtzis University of Ioannina, Agrinio, Greece

Thomas A. Miller

Massachusetts Institute of Technology and Howard Hughes Medical Institute, Cambridge, USA

University of California, Riverside, USA Series: Contemporary Topics in Entomology

Reflecting important new discoveries and advances in the field, this fifth edition presents a survey of various aspects of geomicrobiology, including the microbial role in the formation and degradation of minerals and fossil fuels and elemental cycling. It explores the role of microbes in early evolution, as well as in the lithosphere, deep subsurface, and hydrosphere. This edition includes more foundational information, covering important principles and methods for identification and function of specific microbes in a particular process. Generously laden with tables, graphics, diagrams, and photographs, the remainder of the book examines the geomicrobial aspects of a wide range of minerals.

Like its predecessors in the set, this volume illustrates the important ramifications symbiosis research has for evolutionary biology, microbiology, parasitology, physiology, genetics, and animal behavior. It is especially relevant to the control of agricultural and disease-carrying pests worldwide. The text includes pioneering chapters on paratransgenesis in termites, bacterial symbionts in Anopheles spp. and other mosquito vectors, endosymbionts of lice, and the structure and function of the bacterial community associated with the Mediterranean fruit fly. These studies suggest practical applications in pest control involving novel, pesticidefree, biologically controlled approaches.

Catalog no. 7906, ISBN: 978-0-8493-7906-2 December 2008, 7 x 10, 628 pp. Suggested Price: $199.95 / £127.00

Volume 3 Catalog no. 6410X, ISBN: 978-1-4200-6410-0 October 2008, 7 x 10, 384 pp. Suggested Price: $119.95 / £76.99

Microbiology

Geomicrobiology

Also check out earlier editions

Handbook of Listeria monocytogenes Edited by

Dongyou Liu Human Genetic Signatures, North Ryde, NSW, Australia

Once feared as a deadly intracellular bacterium with the extraordinary capacity to survive a wide array of arduous external stressors, Listeria monocytogenes is increasingly recognized as a preferred vector for delivering anti-infective and anticancer vaccine molecules. A reliable, single-source reference on the fundamental aspects of this bacterium, Handbook of Listeria monocytogenes explores its biology and pathogenicity, including epidemiology and stress responses. It examines identification and detection techniques such as phenotypic and genotypic identification, strain typing, and virulence determination. It also details the current knowledge of genetic manipulation of Listeria, including comparative genomics, genomic divisions, epidemic clones and population structure, and analysis of cell envelope proteins. And finally, it covers innate and adaptive immunity against Listeria, and examines its use for vaccine development. Catalog no. 51407, ISBN: 978-1-4200-5140-7 April 2008, 7 x 10, 552 pp. Suggested Price: $169.95 / £108.00

Handbook of Microbiological Media

Volume 1 This volume is highlighted by an examination of Wolbachia, which continues to emerge as a viable vehicle for the delivery of anti-malarial and anti-plant virus strategies. The book’s interdisciplinary approach makes it an appropriate reference for professionals from any field investigating symbiosis. Catalog no. 1286, ISBN: 978-0-8493-1286-1 2003, 7 x 10, 368 pp. Suggested Price: $129.95 / £82.00

Volume 2 In this volume, a few repeat authors from Volume 1 describe new aspects of their research, while a new group covers recent developments, including the recent “bug in a bug” mealy bug case, and two new examples of using symbionts in crop protection. Catalog no. 4194, ISBN: 978-0-8493-4194-6 2006, 7 x 10, 304 pp. Suggested Price: $129.95 / £82.00

Fourth Edition

Laboratory Biosecurity Handbook

Ronald M. Atlas

Reynolds M. Salerno and Jennifer Gaudioso

University of Louisville, Kentucky, USA

Sandia National Laboratories, Albuquerque, New Mexico, USA

This latest edition of a bestseller carries on the tradition of CRC handbook excellence. This updated volume lists the formulations, methods of preparation, and uses for over four thousand microbiological media. With 30% more entries than the previous editions, the book includes recent information on an international collection of microorganisms and expanded information of yeast, algae, and Archaea. The book also contains formulations and uses of media for isolation, culture, identification, and maintenance of microorganisms. The entries are arranged alphabetically by medium name and include synonyms, sources, trademarks, and more.

In recognition of the vital need to protect legitimate facilities from the theft and misuse of dangerous pathogens and toxins, the Laboratory Biosecurity Handbook is a guide to the implementation of pathogen protection programs. The first sections offer a historical overview of biological weapons activity, key principles of biosecurity and its integration into existing frameworks, as well as a discussion of biosecurity risk. Later sections discuss biosecurity risk assessments, describe detailed components of a biosecurity program, and offer a graded approach to biosecurity through multiple risk levels. The work also covers risk prioritization of biological assets and biosecurity training.

Catalog no. K10224, ISBN: 978-1-4398-0406-3 February 2010, 8-1/2 x 11, 2044 pp. Suggested Price: $199.95 / £127.00

Catalog no. 6475, ISBN: 978-0-8493-6475-4 June 2007, 6 x 9, 208 pp. Suggested Price: $104.95 / £66.99

For more information and a complete list Lactic Acid Bacteria Microbiological and Functional Aspects, Third Edition, Revised and Expanded

Edited by

Steven Percival

Microbiology

Edited by

Advanced Medical Solutions, Ltd., UK

Seppo Salminen, Atte von Wright, and Arthur C. Ouwehand

Keith Cutting

With more than 25 percent revised material, this third edition provides an excellent overview of current research on the function, utilization, and nutritional aspects of lactic acid bacteria. The book showcases the scientific, commercial, and technological findings of 37 international contributors that may impact the quality, taste, and dietary value of foods such as milk, cereal, vegetables, and meat. It contains chapters ranging from topics on mathematical modeling and vegetable fermentation to techniques for the analysis of gut microbiota and probiotics for fish. It also features information on future research directions for the utilization of lactic acid bacteria.

It is not the presence of bacterial organisms but their interaction with hosts/ patients that determine their influence on wound healing. Documenting this critical but often ignored aspect of wound healing, this volume discusses how body changes effect the microbiology and biology of human wounds in relation to infection and the non-healing wound. It presents scientific and clinical knowledge regarding chronic and acute wounds, and discusses inflammation, epithelization, granulation tissue, and tissue remodeling. It also details techniques for controlling chronic and acute wounds and covers the mode of action and efficacy of anti-infectives used in treating wounds.

Catalog no. DK1291, ISBN: 978-0-8247-5332-0 July 2004, 7 x 10, 656 pp. Suggested Price: $259.95 / £165.00

Catalog no. 7993X, ISBN: 978-1-4200-7993-7 April 2010, 6-1/8 x 9-1/4, 400 pp. Suggested Price: $149.95 / £95.00

Buckinghamshire University College, Chalfont, St. Giles, UK

Listeria, Listeriosis, and Food Safety Third Edition Edited by

Elliot T. Ryser

Molecular Detection of Foodborne Pathogens

Michigan State University, East Lansing, USA

Edited by

Elmer H. Marth

Dongyou Liu

University of Wisconsin, Madison, USA Series: Food Science and Technology, 92

Microbiology of Wounds

This third edition of a bestseller incorporates recent findings to present readers with a complete overview of foodborne listeriosis, including information on listeriosis in animals and humans, pathogenesis, methods of detection, and subtyping. Two additional chapters deal with risk assessment, cost of outbreaks, regulatory control in various countries, and future directions for research. The text covers many high-risk foods including fermented and unfermented dairy products, meat, poultry, fish, seafood, and products of plant origin. This authoritative resource has proven to be a critical tool for those involved with preventing and curbing outbreaks of this dangerous pathogen. Catalog no. DK3089, ISBN: 978-0-8247-5750-2 March 2007, 7 x 10, 896 pp. Suggested Price: $195.95 / £127.00

Microbial Limit and Bioburden Tests Validation Approaches and Global Requirements, Second Edition Lucia Clontz

Human Genetic Signatures, North Ryde, NSW, Australia

One of the most effective ways to control and prevent human foodborne infections is to implement a pathogen surveillance system. Addressing the biology, epidemiology, and pathogenesis of more than 60 microorganisms, this volume demonstrates how to implement a surveillance system that uses state-ofthe-art molecular techniques to quickly detect and identify bacterial, fungal, viral, and parasitic pathogens. Each chapter contains a concise review of the discussed pathogen; a detailed description of current molecular procedures for its detection and identification, including ready-to-use protocols; and a discussion on further research needs pertaining to improved diagnosis. Catalog no. 76434, ISBN: 978-1-4200-7643-1 July 2009, 8-1/2 x 11, 905 pp. Suggested Price: $159.95 / £97.00

Pictorial Atlas of Soil and Seed Fungi Morphologies of Cultured Fungi and Key to Species, Third Edition Tsuneo Watanabe

Diosynth Biotechnology, a part of Schering-Plough, Morrisville, North Carolina, USA

Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan

Often called the “industry bible,” Microbial Limit and Bioburden Tests: Validation Approaches and Global Requirements provides a practical guide to microbial limit methodologies. This second edition has been substantially updated and expanded to include the most recent microbial limit tests and bioburden testing mandated by USP-NF. A comprehensive reference source, it reflects current industry standards, regulatory expectations, and the latest technical and scientific information. This edition addresses topics such as water testing and also includes chapters that provide complete coverage of biofilms, environmental monitoring, and microbial identification.

Recent studies indicate that fungi can be the prime cause of sinusitis, asthma, and allergenic troubles. They have also come into demand as sources of biological control agents. Tsuneo Watanabe’s book remains one of the few works that details information on techniques for isolating, culturing, and identifying soil and seed fungi. He presents the results of his soil-borne plant disease studies, including pathological and mycological aspects. This third edition features emphasis on basidiomycetous fungi, colonies of fresh agar cultures, and dried specimens. The book presents fungal species illustrated in brilliant detail using original photomicrographs.

Catalog no. 53485, ISBN: 978-1-4200-5348-7 October 2008, 6-1/8 x 9-1/4, 280 pp. Suggested Price: $189.95 / £121.00

Catalog no. K10231, ISBN: 978-1-4398-0419-3 February 2010, 8-1/2 x 11, 396 pp. Suggested Price: $159.95 / £99.00

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m The Ecology, Biodiversity and Bioremediation Potential of Microorganisms in Extremely Cold Environments Edited by

Asim K. Bej, Jackie Aislabie, and Ronald M. Atlas The first book to focus on bioremediation in the polar regions, this volume examines the diversity of polar microorganisms and their ability to degrade petroleum hydrocarbons that contaminate polar terrestrial and aquatic environments. Providing a unique perspective of these microorganisms in extreme cold temperatures, the book focuses on their taxonomy, physiology, biochemistry, population structure, bioremediation potential, and potential for biotechnology applications. Leading investigators in the field provide complete coverage of the microbiology relevant to the study of biodiversity and biodegradation of pollutants in the Arctic and Antarctic. Catalog no. 83848, ISBN: 978-1-4200-8384-2 December 2009, 6-1/8 x 9-1/4, 430 pp. Suggested Price: $159.95 / £99.00

Rapid Detection and Characterization of Foodborne Pathogens by Molecular Techniques Robert E. Levin University of Massachusetts, Amherst, USA

Written by one of the most prolific and respected researchers in food safety, this volume describes molecular techniques for the detection and discrimination of major infectious bacteria associated with foods. Each chapter deals with a specific organism and techniques applied to that organism. Particular focus is placed on genes associated with pathogenicity used in the polymerase chain reaction (PCR), including real-time PCR for specific detection of pathogenic bacteria, as well as the inherent limitations of such methodology with certain pathogens. Methods for extracting microorganisms from complex food matrices andDNA purification techniques are also emphasized. Catalog no. 92421, ISBN: 978-1-4200-9242-4 October 2009, 6-1/8 x 9-1/4, 608 pp. Suggested Price: $169.95 / £108.00 Molecular Biology

Practical Atlas for Bacterial Identification Second Edition D. Roy Cullimore

Cancer Epigenetics Edited by

Trygve Tollefsbol

Droycon Bioconcepts Inc., Regina, Saskatchewan, Canada

University of Alabama at Birmingham, USA

In a radical departure from the classical reductionist identification of bacteria dominated by genetic and biochemical analysis of separated strains of bacteria, this book takes a generalistic approach utilizing the form, function, and habitat of communities of bacteria. This completely revised and updated second edition introduces the concept of bacteria community intelligence as reflected in corrosion, plugging, and shifts in the quality parameters in water, gas, oil, food, or even air. The book allows readers to start with a symptom, uncover the bacterial activities, and then identify the communities distinctly enough to enable management and control.

It has become increasingly apparent during the past few decades that heredity is not the sole determining factor in disease development. As a result, the field of epigenetics is now the focus of many of the most exciting and significant advances in cancer research. Providing the most up-to-date and relevant information available, this text presents in-depth discussions of DNA methylation analysis and cancer, histone modifications and cancer, and other epigenetic aspects of cancer. This book explores the role of epigenetics in the diagnosis, prognosis, and therapy of cancer and offers a comprehensive overview of current and potential new epigenetics advancements.

Catalog no. 87975, ISBN: 978-1-4200-8797-0 May 2010, 6-1/8 x 9-1/4, 523 pp. Suggested Price: $139.95 / £89.00

Catalog no. 45792, ISBN: 978-1-4200-4579-6 September 2008, 7 x 10, 472 pp. Suggested Price: $149.95 / £95.00

Practical Handbook of Microbiology Second Edition

Textbook

Edited by

Engineering Genetic Circuits

Emanuel Goldman

Chris J. Myers

Westbury Diagnostics Inc., New York, USA

University of Utah, Salt Lake City, USA Series: Chapman & Hall/CRC Mathematical & Computational Biology, 26

Providing basic knowledge and practical information in a clear and concise single volume, the second edition of the bestselling Practical Handbook of Microbiology provides in-depth chapters on all aspects of the field, from classical microbiology to genomics. Reflecting the recent sweeping changes in the field, yet retaining the popular format of the original, this second edition includes many chapter rewrites and more than 20 expanded chapters. Various brief taxonomy sections from the first edition are now complete chapters with descriptions of genus and species, and several tables have been updated and revised along with the addition of a survey table of selected eubacteria.

This text presents the modeling, analysis, and design methods for systems biology. It discusses how to examine experimental data to learn about mathematical models, develop efficient abstraction and simulation methods to analyze these models, and use analytical methods to design new circuits. The author reviews basic molecular biology and biochemistry principles, covers several methods for modeling and analyzing genetic circuits, and uses phage lambda as an example throughout to help illustrate the methods. He also explores the emerging area of synthetic biology. iBioSim software, lecture slides, and a password-protected solutions manual are available on the author’s website.

Catalog no. 9365, ISBN: 978-0-8493-9365-5 August 2008, 7 x 10, 864 pp. Suggested Price: $159.95 / £99.00

Catalog no. C3244, ISBN: 978-1-4200-8324-8 July 2009, 6-1/8 x 9-1/4, 306 pp. Suggested Price: $69.95 / £44.99

University of Medicine & Dentistry of New Jersey, USA

Lorrence H. Green

Microbiology / Molecular Biology

Polar Microbiology

For more information and a complete list Epigenetics in Biology and Medicine Edited by

Manel Esteller Spanish National Cancer Centre, Madrid

Molecular Biology / Neuroscience 14

Epigenetic changes are essential to normal development, but these changes can also cause problems including the disabling of genes that suppress tumors. At present, more than a dozen drugs that target epigenetic changes are in clinical trials. Epigenetics in Biology and Medicine offers a comprehensive overview of epigenetics, both in normal functions and disease states. This book presents contributions from international experts who address both theoretical and methodological issues. They discusses cell biology and the role of epigenetics in human, animal, and plant diseases. The text also covers DNA methylation inhibitors, histone modifications, and epigenomics, as well as the impact that diet has on epigenetic changes. Catalog no. 7289, ISBN: 978-0-8493-7289-6 September 2008, 6-1/8 x 9-1/4, 312 pp. Suggested Price: $149.95 / £95.00

Paramecium Genetics and Epigenetics G.H. Beale Chamberlain Nursing Home, Edinburgh, UK

John R. Preer, Jr. Indiana University, Bloomington, USA

Taking a rather unconventional view of genetics, this book explores how to use paramecium as a basis for studying complex cells. It describes the morphology, reproduction, and life cycle stages of paramecium and outlines methods for studying genetic processes, such as Mendelian, caryonidal, and cytoplasmic transmissions. The authors offer detailed accounts of bygone hypotheses, such as the plasmagene and metagon hypotheses, and examine epigenetic mechanisms in antigenic expression and cortical inheritances. They also explore interesting work on ciliate genetics, including a gene cloning method via functional complementation and homology-dependent inheritance. Catalog no. TF1277, ISBN: 978-0-415-25785-5 March 2008, 6-1/8 x 9-1/4, 216 pp. Suggested Price: $99.95 / £63.99

Handbook of Nucleic Acid Purification

Regulation of Gene Expression by Small RNAs

Edited by

Dongyou Liu

Rajesh K. Gaur and John J. Rossi

Human Genetic Signatures, North Ryde, NSW, Australia

Beckman Research Institute, Duarte, California, USA

An all-encompassing volume on nucleic acid purification strategies for bacteria, viruses, fungi, parasites, mammals, and plants, this book emphasizes sample preparation methods for direct molecular applications. Each chapter provides a concise review of historical background and purification principles, a detailed description of current techniques, including several state-of-art protocols for large and small-scale preparations, and a discussion for future development trends. A comprehensive, reliable reference, the book supplies a useful roadmap for clinical, forensic, and research scientists involved in the molecular analysis of biological specimens.

Recent research demonstrates that defects in the processing mechanisms of small non-coding RNAs are linked to various human diseases. This text explores the latest research on microRNAs and their functional roles in cells and organisms. Written by international experts, discussion includes the identification, characterization, and structure-function analysis of microRNAs; the study of microRNAs in development, cancer, and viruses; and the applications of microRNAs with respect to gene regulation, functional genomics and therapeutics. This book is a valuable reference for established researchers, fellows, and advanced students.

Catalog no. 70967, ISBN: 978-1-4200-7096-5 January 2009, 7 x 10, 584 pp. Suggested Price: $159.95 / £97.00

Catalog no. 9169, ISBN: 978-0-8493-9169-9 April 2009, 6-1/8 x 9-1/4, 440 pp. Suggested Price: $149.95 / £89.00

Advances in the Neuroscience of Addiction Edited by

Cynthia M. Kuhn

Microarray Methods and Protocols Robert S. Matson Orange, California, USA

This volume provides insight into present and future uses for microarray technology. The book presents an overview of companies providing arrays, the type of arrays available, array construction processes, substrate chemistry, array printing, and quality control. With a focus on nucleic acid microarrays of biomedical relevance and the use of microarrays in drug discovery, the text describes the application of gene expression arrays to identify drug targets for human diseases and to predict possible drug toxicity problems. The relatively new field of protein microarray technology is also discussed, including technical challenges and how they have been overcome. Catalog no. 46659, ISBN: 978-1-4200-4665-6 January 2009, 6-1/8 x 9-1/4, 216 pp., Soft Cover Suggested Price: $129.95 / £78.99

Duke University Medical Center, Durham, North Carolina, USA

George F. Koob The Scripps Research Institute, La Jolla, California, USA Series: Frontiers in Neuroscience

Based on contributions from leading experts, this book presents an excellent overview of the available and emerging approaches used to investigate the biological mechanisms of drug addiction. Discussion includes the behavioral strategies and characteristics of addiction as well as the mechanistic approaches to understanding the underlying neurobiology. The authors provide information from mathematical models, model organisms, and traditional, well-characterized animal models as well as experiments conducted in humans. They deliver a comprehensive introduction to the methodologies of the field for students and beginning researchers and an essential reference source for established investigators. Catalog no. 7391, ISBN: 978-0-8493-7391-6 January 2010, 6-1/8 x 9-1/4, 240 pp. Suggested Price: $139.95 / £89.00

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

Edited by

Autism

Johns Hopkins Asthma Center, Baltimore, Maryland, USA

Oxidative Stress, Inflammation, and Immune Abnormalities

Daniel Weinreich

Abha Chauhan, Ved Chauhan, and Ted Brown

Bradley J. Undem University of Maryland, Baltimore, USA

Institute for Basic Research, Staten Island, New York, USA

Advances in Vagal Afferent Neurobiology takes a comprehensive approach in which all aspects of the vagal afferent system are considered from the terminals in the visceral tissues to the neural pathways within the central nervous system. Within this contextual framework, the book reviews the development, neurochemistry, anatomy, biophysics, pharmacology, and physiology of the vagal afferent nerves. The authors present experimental techniques used to investigate development, morphology,

Recently, the CDC issued an alert indicating that autism may impact one out of every150 children. While the syndrome is still officially labeled as idiopathic, research shows the cause of autism may possess genetic, environmental, and possibly immunological factors and that it has at least a correlation to oxidative stress. This book collects work from researchers who report on evidence indicating links between autism and a number of oxidative stress-related abnormalities such as neuroinflammation, mitochondrial dysfunction, membrane and metabolism abnormalities, and signal transduction. The text also reports on potential avenues for new therapeutic intervention strategies.

Catalog no. 2131, ISBN: 978-0-8493-2131-3 June 2005, 240x160, 544 pp. Suggested Price: $164.95 / £92.00

Animal Models of Cognitive Impairment

Catalog no. 68814, ISBN: 978-1-4200-6881-8 October 2009, 6-1/8 x 9-1/4, 452 pp. Suggested Price: $159.95 / £99.00

Edited by

Automated EEG-Based Diagnosis of Neurological Disorders

Edward D. Levin

Inventing the Future of Neurology

Duke University Medical Center, Durham, North Carolina, USA

Hojjat Adeli

Jerry J. Buccafusco

Ohio State University, Columbus, USA

Medical College of Georgia, Augusta, USA Series: Frontiers in Neuroscience, 30

Samanwoy Ghosh-Dastidar

Animal models of cognitive function, including learning, memory, and attention, are critical for determining the neurobehavioral basis for cognition and for the development of new therapeutic treatments for cognitive impairment. Animal Models of Cognitive Impairment features an integrated approach that combines molecular and neurochemical approaches in translational models with behavioral and clinical applications. The text also discusses current research on genetic, lesion, pharmacological toxicant, and aging models. The book then explores the significance of this research to the treatment of various addictions and disorders such as stroke, autism, Alzheimer’s, schizophrenia, and ADHD.

Based on the authors’ ground-breaking research, this book presents a novel approach for automated EEG-based diagnosis of neurological disorders such as epilepsy. The authors have developed an innovative method that has been shown to diagnose epilepsy and detect seizures with an accuracy rate of 96 percent. Their method is based on the adroit integration of three computing and problem solving paradigms: neural networks, wavelets, and chaos theory. The text introduces each of these computing paradigms along with a number of sophisticated mathematical algorithms. It concludes with applications of the method to epilepsy and to Alzheimer’s disease.

Catalog no. 2834, ISBN: 978-0-8493-2834-3 June 2006, 6-1/8 x 9-1/4, 400 pp. Suggested Price: $149.95 / £95.00

Catalog no. K10784, ISBN: 978-1-4398-1531-1 February 2010, 6-1/8 x 9-1/4, 424 pp. Suggested Price: $159.95 / £99.00

Atlas of Functional Neuroanatomy

Neuroscience

Advances in Vagal Afferent Neurobiology

Ardmore, Pennsylvania, USA

Biology of the NMDA Receptor Edited by

Second Edition

Antonius M. VanDongen

Walter J. Hendelman, M.D. University of Ottawa, Ontario, Canada

Duke University Medical Center, Durham, North Carolina, USA Series: Frontiers in Neuroscience

Presenting a clear visual guide to understanding the human central nervous system, this second edition includes numerous four-color illustrations, photographs, diagrams, radiographs, and histological material throughout the text. Organized and easy to follow, the book presents an overview of the sensory, central nervous, motor, and limbic systems. It also features an updated, interactive CD-ROM with full text, color illustrations, 3-D visualization, roll-over labeling, and flash animations. Containing a glossary of terms, this is an essential reference tool for medical and allied health professionals studying neuroanatomy, neuroscience, and neurology.

The NMDA receptor, a subclass of the ionotropic glutamate receptor family, plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. Biology of the NMDA Receptor describes all important aspects of NMDA receptor biology. The text highlights exciting new discoveries that have been made over the past decade. It provides a comprehensive review of various molecular genetics studies that illustrate the importance of this class of receptors. In addition, the book presents a discussion of recent crystallographic x-ray structures of its ligand binding domains.

Catalog no. 3084, ISBN: 978-0-8493-3084-1 October 2005, 8-1/2 x 11, 296 pp., Soft Cover Suggested Price: $59.95 / £38.99

Catalog no. 44141, ISBN: 978-1-4200-4414-0 October 2008, 6-1/8 x 9-1/4, 350 pp. Suggested Price: $149.95 / £95.00

For more information and a complete list DNA Arrays Technologies and Experimental Strategies

Circadian Physiology Second Edition

Elena V. Grigorenko

University of South Carolina, Allendale, USA

Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts, USA Series: Frontiers in Neuroscience, 12

Circadian Physiology highlights the basic processes and research findings in circadian biology and describes how this knowledge applies to the prevention of jet lag and the malaise associated with shift work, the treatment of sleep disorders and depression, and the timing for effective administration of medicines. The second edition is updated to include research developments such as the discovery of new retinal photoreceptors, the identification of several non-hypothalamic circadian pacemakers, and the elucidation of genomic and proteomic mechanisms of biological timing. Each chapter includes a summary, exercises, and suggestions for further reading.

A quantum leap in technology took place a few years ago with the introduction of DNA arrays that have been developed in response to the need for simultaneous analysis of the patterns of expression of genes. This volume offers a view of different aspects of this rapidly developing technology, including oligonucleotide and electrochemical arrays. Distinguished investigators from academia and industry provide insights into methodological fundamentals of construction of DNA arrays, optimization of hybridization conditions, the use of expression data in bioinformatics, different software tools, and the application of microarray technology for drug discovery process.

Catalog no. 2233, ISBN: 978-0-8493-2233-4 October 2005, 8-1/2 x 11, 688 pp. Suggested Price: $129.95 / £82.00

Catalog no. 2285, ISBN: 978-0-8493-2285-3 December 2001, 6-1/8 x 9-1/4, 184 pp. Suggested Price: $149.95 / £95.00

Roberto Refinetti, Ph.D.

Neuroscience

Computational Neuroscience

Edited by

The Dynamic Synapse

Realistic Modeling for Experimentalists

Molecular Methods in Ionotropic Receptor Biology

Edited by

Erik De Schutter

Josef T. Kittler and Stephen J. Moss

University of Antwerp-UIA, Wilrijk, Belgium Series: Frontiers in Neuroscience, 5

University College of London, UK Series: Frontiers in Neuroscience, 29

Designed primarily as an introduction to realistic modeling methods, Computational Neuroscience: Realistic Modeling for Experimentalists focuses on methodological approaches, the selection of appropriate methods, and the identification of potential pitfalls. What makes this resource unique is the inclusion of a CD-ROM that furnishes interactive modeling examples. It contains tutorials and demos, movies and images, and the scripts necessary to run the full simulations described in the examples. Each chapter includes theoretical foundations, parameters needed, appropriate software descriptions, evaluation of the model, future directions, examples linked to the CD-ROM, and references.

Bringing together the latest information into one easily accessible resource, The Dynamic Synapse: Molecular Methods in Ionotropic Receptor Biology explores the diverse tools and technologies used to study synaptic processes. Written by world-renowned leaders in the field, the book delineates newly developed techniques, methods, and conceptual advances used for studying neurotransmitter receptors and other synaptic proteins. Providing detailed information on cutting-edge techniques that can be applied to this area, the book is useful to both new and experienced synaptic physiologists as well as the wider neuroscience community.

Catalog no. 2068, ISBN: 978-0-8493-2068-2 November 2000, 6-1/8 x 9-1/4, 368 pp. Suggested Price: $149.95 / £95.00

Catalog no. 1891, ISBN: 978-0-8493-1891-7 March 2006, 6-1/8 x 9-1/4, 336 pp. Suggested Price: $159.95 / £99.00

Endocannabinoids The Brain and Body’s Marijuana and Beyond

Concussive Brain Trauma Neurobehavioral Impairment & Maladaption, Second Edition Rolland S. Parker New York University School of Medicine, USA

Continuing the tradition of the bestselling first edition, this second edition provides comprehensive coverage of neurobehavioral disorders in children and adults following impact and acceleration accidents. Completely revised and updated, the book includes comprehensive coverage of consciousness including normal, acute, and persistent alterations. Drawing on his training, education, and experience in human physiology, neuroanatomy, and endocrinology, the author not only gives readers a solid foundation for understanding, diagnosing, and treating concussive brain trauma, but also gives them tools to increase standards of care. Catalog no. 8039, ISBN: 978-0-8493-8039-6 May 2010, 7 x 10, 530 pp. Suggested Price: $159.95 / £99.00

Edited by

Emmanuel S. Onaivi William Paterson University, Wayne, New Jersey, USA

Takayuki Sugiura Teikyo University, Kanagawa, Japan

Vincenzo Di Marzo Dirigente di Ricerca, Puzzuoli, Napoli, Italy

This volume explores research on marijuana-like substances produced naturally by the human body and brain. These endogenous lipid molecules, or endocannabinoids, constitute a uniquely conserved and ubiquitous physiological control system in a variety of species and play fundamental roles in development and cell death. The authors discuss this remarkable progress in marijuana research, including identification of gene-encoding endocannabinoid receptors, isolation of endocannabinoids and entourage ligands, and functional identification of transporters and enzymes for the biosynthesis and degradation of these endogenous substances. Catalog no. TF1609, ISBN: 978-0-415-30008-7 November 2005, 7 x 10, 584 pp. Suggested Price: $164.95 / £105.00

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Mechanisms, Models, and Translational Perspectives

In Vivo Optical Imaging of Brain Function

Edited by

Second Edition

Jong M. Rho

Edited by

Barrow Neurological Institute, Phoenix, Arizona, USA

Ron Frostig

Raman Sankar University of California School of Medicine, Los Angeles, USA

University of California, Irvine, USA Series: Frontiers in Neuroscience, 39

Written for researchers and students in neurology and neuroscience or general practitioners interested in epilepsy, this text offers a bridge across the so-called translational divide to cover innovative treatment strategies that while based on scientific principles, have yet to be tested rigorously in clinical settings. The text features contributions of researchers in adult and pediatric epilepsy who cover a range of topics, including gene therapy, metabolic regulation, and neuroprotective strategies. It offers an understanding of the pathogenesis and mechanisms of various epilepsy syndromes, highlights therapies with the greatest potential, and identifies challenges common to researchers.

Updated to reflect continuous development in this emerging area, this new edition reaches across disciplines to review a variety of noninvasive optical techniques used to study activity in the living brain. Leading authorities from such diverse areas as optical hardware, cognitive behavior, and neuroscience present a host of perspectives that range from a single neuron to large assemblies of neurons several million strong, captured at various temporal and spatial resolutions. Introducing techniques that were not available just a few years ago, the book describes their theory, setup, and analytical methods, and provides examples that highlight the advantages of each particular method.

Catalog no. 8559X, ISBN: 978-1-4200-8559-4 June 2010, 8-1/2 x 11, 500 pp. Suggested Price: $189.95 / £121.00

Catalog no. 76841, ISBN: 978-1-4200-7684-4 May 2009, 6-1/8 x 9-1/4, 428 pp. Suggested Price: $149.95 / £89.00

Textbook

Fat Detection

The Integrated Nervous System

Taste, Texture, and Post Ingestive Effects

A Systematic Diagnostic Approach

Jean-Pierre Montmayeur

Walter J. Hendelman

Centre des Sciences du Hout, Dijon, France

University of Ottawa, Ontario, Canada

Johannes le Coutre

Peter Humphreys

Nestle Research Center, Lausanne, Switerland Series: Frontiers in Neuroscience, 40

Children’s Hospital of Eastern Ontario, Canada

Christopher Skinner

Taking a multidisciplinary approach, this volume sheds new light on critical concerns regarding dietary fat and its relation to obesity. Going far beyond the well-known concerns, it offers new scientific data on the many aspects of fat consumption, including psychological, behavioral, genetic, and physiological factors that contribute to its desirability, perception, intake, and impact on human health. Bringing together research across various fields, it includes information on genetic predisposition, neural imaging, and endocrine impacts on metabolism, and provides a progressive integrated view on fat taste, fat preference, and nutrition at the molecular level.

Ottawa Hospital, Ontario Canada

Catalog no. 67753, ISBN: 978-1-4200-6775-0 September 2009, 6-1/8 x 9-1/4, 643 pp. Suggested Price: $149.95 / £95.00

The Female Brain

To demonstrate the connection between academic neuroanatomy and the practice of clinical neurology, this innovative text presents carefully chosen clinical cases that illustrate how the nervous system is constructed and how it functions under normal circumstances. Providing the foundation needed to encounter neurological diseases, it teaches students and residents how to integrate a patient’s clinical history and examination with neuroanatomy. In addition to color illustrations throughout, the book is supplemented by an invaluable DVD for further exploration as well as access to a state-of-the-art website with additional materials that are updated periodically. Catalog no. 45970, ISBN: 978-1-4200-4597-0 September 2009, 8-1/2 x 11, 352 pp. Suggested Price: $79.95 / £49.99

Second Edition

Manual of Stroke Models in Rats

Cynthia Darlington

Edited by

University of Otago, Dunedin, New Zealand Series: Conceptual Advances in Brain Research, 9

Yanlin Wang-Fischer

The first edition of this bestseller laid the groundwork for understanding the female brain and examined evidence of structural and functional differences between the brains of males and females. Addressing a wealth of new research, the second edition continues in this vein, leading readers through the basic principles of anatomy and physiology and on to the complex behavioral functions which constitute the workings of the normal and abnormal female brain. Filled with rigorous scientific analysis in an easily accessible format, the book delineates gender-based differences between brains and explains why they should be considered when designing research and clinical studies.

While new insights into the mechanisms and the treatment of stroke have been obtained from animal experiments over the past several years, this is the first book in more than two decades to compile research in this essential area. Calling on a group of cutting-edge researchers, it offers detailed explanations of the methods and techniques for accomplishing different stroke models in rats. As of now, no specific neuroprotective treatment for ischemic stroke is available. This book provides a starting point for those researchers employing stroke models to develop new drugs to counteract this problem.

Catalog no. 77449, ISBN: 978-1-4200-7744-5 April 2009, 6-1/8 x 9-1/4, 266 pp. Suggested Price: $129.95 / £78.99

Neuroscience

Epilepsy

Palatin Technologies, Cranbury, New Jersey, USA

Catalog no. 9578, ISBN: 978-0-8493-9578-9 August 2008, 7 x 10, 352 pp., Soft Cover Suggested Price: $99.95 / £63.99

For more information and a complete list Methods in Alcohol-Related Neuroscience Research Edited by

Yuan Liu National Institute of Neurological Disorders & Stroke, Bethesda, Maryland, USA

Edited by

David M. Lovinger

University of Arizona, Tucson, USA Series: Frontiers in Neuroscience, 25

Laboratory of Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Nashville, Tennessee, USA Series: Frontiers in Neuroscience, 14

Neuroscience 18

Methods in Insect Sensory Neuroscience

Written by a panel of experts, Methods in Alcohol-Related Neuroscience Research not only provides information of a technical nature but also gives an overview of the effects of alcohol on the brain. It offers guidance for investigators doing research at the molecular, cellular, systems, and behavioral levels. These techniques include a wide variety of approaches, ranging from gene mapping and examination of molecular interactions of alcohol at the sub-cellular level to recording of neural activities in freely-behaving animals and imaging alcohol effects on the living human brain. Catalog no. 0347, ISBN: 978-0-8493-0203-9 February 2002, 6-1/8 x 9-1/4, 416 pp. Suggested Price: $149.95 / £95.00

Thomas A. Christensen

Written by recognized experts in sensory biology, Methods in Insect Sensory Neuroscience synthesizes the latest information and reviews the most current methods for studying the specialized sensory systems of insects. Bridging the gap between experimentalists and theorists, the book covers a wide range of techniques, including anatomical pathway tracing, electrophysiological recording, genetic and pharmacological manipulations, computational modeling, and behavioral observations. Each chapter discusses the most challenging questions facing sensory neuroscience today and provides a unique synopsis of the developments that are driving the field forward. Catalog no. 2024, ISBN: 978-0-8493-2024-8 December 2004, 6-1/8 x 9-1/4, 464 pp. Suggested Price: $149.95 / £95.00

Methods in Chemosensory Research

Methods in Pain Research

Edited by

Sidney A. Simon and Miguel A. L. Nicolelis

Lawrence Kruger

Duke University Medical Center, Durham, North Carolina, USA Series: Frontiers in Neuroscience, 9

University of California, Los Angeles, USA Series: Frontiers in Neuroscience, 6

Methods in Chemosensory Research describes new molecular, electrophysiological, engineering, genetic, behavioral, psychophysical, and imaging techniques that are able to investigate the basic neuronal mechanisms underlying chemoreception. Written by leaders in the field of neuronal chemoreception specializing in olfaction, gustation, baroreception, and chemical irritation caused by environmental pollutants, this book combines novel methods to investigate all aspects of taste and olfaction. These methods range from the molecular level to the investigation of individual cell taste and olfactory epithelia.

Addressing a rapidly growing area of neuroscience, Methods in Pain Research is a single volume survey of the methods used to study a reaction or ‘sensory report’ in humans that can only be inferred by indirect means in animal or tissues studies. It contains source material, useful advice, and guidance to specific details as well as examples of current usage. The book examines techniques used in studying pain, including gene linkage, brain imaging methods, the use of transgenic rodent models, painful sensory neuropathy models, and more. The material also covers conventional methods of pain study, such as anatomical and electophysiological techniques.

Catalog no. 2329, ISBN: 978-0-8493-2329-4 September 2001, 6-1/8 x 9-1/4, 552 pp. Suggested Price: $149.95 / £95.00

Methods in Drug Abuse Research Cellular and Circuit Level Analyses Edited by

Catalog no. 0035, ISBN: 978-0-8493-0035-6 June 2001, 6-1/8 x 9-1/4, 336 pp. Suggested Price: $159.95 / £99.00

Methods of Behavior Analysis in Neuroscience

Barry D. Waterhouse

Second Edition

MCP-Hahnemann School of Medicine, Philadelphia, Pennsylvania, USA Series: Frontiers in Neuroscience, 17

Jerry J. Buccafusco Medical College of Georgia, Augusta, USA Series: Frontiers in Neuroscience, 3

Pulling information from a wide variety of resources and assembling it into one volume, this book examines cellular and molecular studies of drug actions and behavioral approaches to questions in drug abuse research. The book covers procedures, methods, and equipment used in experiments that in many cases, combine multiple technical approaches. It presents state-of-the-art technical information and critical reviews of the experimental strategies used to dissect the problem of compulsive drug use and addiction at the systems or whole brain level. It also provides insight into the pros and cons of various experimental strategies.

A comprehensive reference for the most well-studied behavioral approaches in animal subjects, this book provides a better understanding of disease effects and new therapeutic treatments. The second edition features new material on the relevance of transgenic mouse models for Alzheimer’s disease, behavioral methods for assessing the cognitive impairment associated with major psychotic disorders, the revival of the scopolamine reversal model for assessing the clinical relevance of new AD drugs, and new approaches to assessing cognitive impairment in aged mice. Each chapter presents theoretical background, methodology, and data interpretation.

Catalog no. 2345, ISBN: 978-0-8493-2345-4 November 2002, 6-1/8 x 9-1/4, 296 pp. Suggested Price: $149.95 / £95.00

Catalog no. 52349, ISBN: 978-1-4200-5234-3 October 2008, 6-1/8 x 9-1/4, 360 pp. Suggested Price: $149.95 / £95.00

Micronutrients and Brain Health

Motor Neurobiology of the Spinal Cord

Edited by

Lester Packer, Helmut Sies, Manfred Eggersdorfer, and Enrique Cadenas

Timothy C. Cope

Series: Oxidative Stress and Disease, 26

Wright State University, Dayton, Ohio, USA Series: Frontiers in Neuroscience, 7

Under the direction of leading experts in oxidative stress, this book addresses cutting-edge areas of research regarding micronutrients and the brain. It discusses identification of brain-specific micronutrients that support function and molecular mechanisms underlying neuroprotectant activity. The book covers agerelated metabolic pathways, mitochondrial nutrients, and neurodegeneration. Additional chapters cover flavonoids, cell signaling, and neuronal functions, as well as the role of choline, amino acids, metals, and other micronutrients in brain health and function. The text places a particular emphasis on lipoic acid, which is shown to be a therapeutic agent in neuropathologies.

Motor Neurobiology of the Spinal Cord provides a comprehensive description of the experimental tools available for investigating the neuronal properties that allow populations of spinal cord neurons to control muscles responsible for limb movements and posture control. By integrating data from many new approaches, this text demonstrates how spinal cord circuits operate under a variety of conditions and explores developments that have been made in motor neurobiology of the spinal cord. It also elucidates concepts and principles relevant to function and structure throughout the nervous system and presents information about changes induced by injury and disease.

Catalog no. 73516, ISBN: 978-1-4200-7351-5 October 2009, 7 x 10, 460 pp. Suggested Price: $169.95 / £108.00

Catalog no. 0006, ISBN: 978-0-8493-0006-6 June 2001, 6-1/8 x 9-1/4, 360 pp. Suggested Price: $159.95 / £99.00

Modern Neurosurgery

Neural Plasticity in Adult Somatic Sensory-Motor Systems

Clinical Translation of Neuroscience Advances

Edited by

Ford F. Ebner

Dennis A. Turner

Vanderbilt University, Nashville, Tennessee, USA Series: Frontiers in Neuroscience, 27

Duke University Medical Center, Durham, North Carolina, USA

Focusing on how increased understanding of brain function affects clinical neuroscience, Modern Neurosurgery: Clinical Translation of Neuroscience Advances explores the interface between non-clinical and clinical neuroscience advances by examining the hypotheses that drive this evolution. The book reviews the relevant underpinnings of new neurosurgical techniques, treatments, and conceptual approaches, which are likely to shape clinical neuroscience over the next decade. A critical aspect of this rational approach is to underscore what needs to be done in each field, potentially leading to further study and improvements. Catalog no. 1482, ISBN: 978-0-8493-1482-7 June 2004, 240x162, 344 pp. Suggested Price: $149.95 / £95.00

Synthesizing current information about sensory-motor plasticity, this book provides an up-to-date description of the dynamic processes that occur in somatic sensory-motor cortical circuits or somatic sensory pathways to the cortex due to experience, learning, or damage to the nervous system. The presentation emphasizes changes in the cortex that are linked to changes in movement or behavior, and it demonstrates the potential for direct brain-based interventions to improve the quality of life for people with sensory-motor disabilities. The book includes studies that document the dynamic changes in system properties that occur with normal experience or in recovery from brain damage. Catalog no. 1521, ISBN: 978-0-8493-1521-3 May 2005, 6-1/8 x 9-1/4, 296 pp. Suggested Price: $149.95 / £95.00

Motor Cortex in Voluntary Movements

Neural Prostheses for Restoration of Sensory and Motor Function

A Distributed System for Distributed Functions

Edited by

John K. Chapin

Alexa Riehle INCM - CNRS, Marseille, France

State University of NewYork Health Science Center, Brooklyn, USA

Karen A. Moxon

The Hebrew University, Jerusalem, Israel

Drexel University, Philadelphia, Pennsylvania, USA Series: Frontiers in Neuroscience, 4

This book presents the most current developments in motor cortex research that allow researchers to read and interpret neural activity and use the data to reconstruct movements. It focuses on how neuronal activity changes during learning, what the motor cortex encodes for, and the neuronal representations of voluntary movements and the mechanism of their generation during learning. Along with its detailed coverage of recent advanced approaches to motor cortex research, the book also includes early historical notes and brief description of classical studies of neuronal activity in frontal sensorimotor fields.

While the creation of a bionic human may still be far into the future, neural prostheses are rapidly becoming viable for patients with injury or disease of the nervous system. This book provides information on the recent advances in neural prosthetic techniques and applications. Divided into two sections, the first section details some of the most successful sensory and motor prosthetic devices available, paying particular attention to the current usefulness and future promise of the devices. The second section explores the growing field of brain-implantable devices for the control of artificial prosthetic devices or neural prosthetics.

Catalog no. 1287, ISBN: 978-0-8493-1287-8 December 2004, 242x168, 448 pp. Suggested Price: $149.95 / £95.00

Catalog no. 2225, ISBN: 978-0-8493-2225-9 September 2000, 6-1/8 x 9-1/4, 312 pp. Suggested Price: $149.95 / £95.00

Eilon Vaadia

Neuroscience

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

For more information and a complete list Neuroanatomical Basis of Clinical Neurology

Edited by

Daniel J. DiLorenzo, MD, PhD, MBA

Edited by

DiLorenzo Biomedical, LLC, Houston, Texas, USA

Orhan Arslan

Joseph D. Bronzino, PhD

Neuroscience

University of South Florida, Tampa, USA

Trinity College, Hartford, Connecticut, USA

Superbly illustrated and clearly written, Neuroanatomical Basis of Clinical Neurology bridges the gap between the disciplines of neuroanatomy and neurology, aiding the understanding of neurologic disorders by investigating their anatomic basis. The extensive coverage of the peripheral and central nervous systems in the context of neurological disorders and conditions sets it apart from other neuroanatomy texts. The author has skillfully integrated text and diagrams, highlighting and clarifying the numerous functionally important pathways in the central and peripheral nervous systems. This volume was chosen as an Outstanding Academic Title for 2002 by CHOICE Magazine.

Comprehensive, practical, and broad in scope, Neuroengineering offers clinical insights on revolutionary technologies from prominent neurosurgeons and neurologists. The book presents a wide range of new developments in the field and high-impact emerging technologies poised to change the industry, described in detail by the experts who invented them. It provides a thorough understanding of the fundamental science and technology behind neural modulation and neurophysiology. Containing features that make it a great reference for students, this book also includes over 150 figures that allow readers to visualize the anatomy, technologies, and surgical procedures discussed in the text.

Catalog no. PA578X, ISBN: 978-1-85070-578-9 August 2001, 8-1/2 x 11, 432 pp., Soft Cover Suggested Price: $67.95 / £42.99

Catalog no. 8174, ISBN: 978-0-8493-8174-4 December 2007, 7 x 10, 408 pp. Suggested Price: $93.95 / £59.99

The Neurobiology of Huntington’s Disease Donald C. Lo

Neuroengineering

Neuroproteomics

Durham, North Carolina, USA

Edited by

Robert E. Hughes

Oscar Alzate

Novato, California, USA Series: Frontiers in Neuroscience

University of North Carolina, Chapel Hill, USA Series: Frontiers in Neuroscience, 42

Highlighting advances in the discovery and development of new drug therapies for neurodegenerative disorders, this volume focuses on the many aspects of the research on drugs to treat Huntington’s disease. It discusses genetics, genomics, and proteomics, and the latest in high-throughput and high-content screening. The authors provide introductory background as well as highly sophisticated information on current and future directions of research. Exploring the interplay between academic and industrial research, the investment community, and nonprofit contributors, the book also examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage.

Edited by Oscar Alzate, this is the newest volume in the CRC Frontiers of Neuroscience Series. With an extensive background in mathematics and physics, Dr. Alzate exemplifies the newest generation of biological systems researchers. He organizes an overview of neuroproteomics that is practical and progressive. Approaches discussed include mass spectrometry, electrophoresis, chromatography, surface plasmon resonance, protein arrays, immunoblotting, computational proteomics, and molecular imaging. Writing about their work, leading researchers detail the principles, approaches, and difficulties of the techniques, showcasing the questions that neuroproteomics can answer and those it raises.

Catalog no. 9000, ISBN: 978-0-8493-9000-5 March 2010, 6-1/8 x 9-1/4, 384 pp. Suggested Price: $139.95 / £89.00

Catalog no. 76256, ISBN: 978-1-4200-7625-7 October 2009, 6-1/8 x 9-1/4, 354 pp. Suggested Price: $159.95 / £99.00

The Neurobiology of Olfaction

New Concepts in Cerebral Ischemia

Edited by

Anna Menini

Rick C. S. Lin

S.I.S.S.A, Trieste, Italy Series: Frontiers in Neuroscience, 41

University of Mississippi Medical Center, Jackson, USA Series: Frontiers in Neuroscience, 13

Reflecting a growing interest, The Neurobiology of Olfaction provides a comprehensive overview of the present status of knowledge and research in this area. With an interdisciplinary approach, it includes content from genetics to behavior and from nematodes to humans. It also contains chapters about the most recent discoveries on odor coding from the olfactory epithelium to cortical centers and about neurogenesis in the olfactory epithelium and in the olfactory bulb. Each chapter is written by a top researcher in the area and provides an extensive list of reviews and original articles for students and scientists interested in further study.

Providing a detailed description of the techniques and theories employed in both basic and clinical research, New Concepts in Cerebral Ischemia delineates the mechanisms underlying neuronal damage induced by ischemia. The book covers methods to elucidate the pathogenesis of ischemia, technologies used in the design of specific strategies to protect neurons from further injury, and new approaches to treat patients with acute ischemic episodes. It includes methods and therapeutic approaches for neuronal protection against acute and chronic ischemic episodes and describes new animal models for ischemia research, including the application of transgenic animals.

Catalog no. 71971, ISBN: 978-1-4200-7197-9 November 2009, 7 x 10, 448 pp. Suggested Price: $159.95 / £99.00

Catalog no. 0328, ISBN: 978-0-8493-0119-3 December 2001, 6-1/8 x 9-1/4, 328 pp. Suggested Price: $149.95 / £95.00

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Nicotinic Receptors in the Nervous System

Primate Audition

Edited by

Duke University Medical Center, Durham, North Carolina, USA Series: Frontiers in Neuroscience, 8

Featuring a unique approach, Nicotinic Receptors in the Nervous System provides integrated coverage of research on neuronal nicotinic systems relevant to smoking addiction and cognitive dysfunction. By bringing together molecular and neurochemical applications, the book provides the key to understanding function and dysfunction of nicotinic systems and how they are significant for disease, addiction, and the development of novel drug treatments. The book presents readers with the basic mechanistic background for these treatments as well as the functional assessment necessary to determine therapeutic effects. Catalog no. 2386, ISBN: 978-0-8493-2386-7 August 2001, 6-1/8 x 9-1/4, 312 pp. Suggested Price: $149.95 / £95.00

Parkinson’s Disease

Asif A. Ghazanfar Princeton University, New Jersey, USA Series: Frontiers in Neuroscience, 16

Bringing together the knowledge of world experts on different aspects of primate auditory function, this book bridges the epistemological gap between primate ethologists and auditory neurobiologists. Leading ethologists, comparative psychologists, and neuroscientists who have developed new experimental approaches apply their methods to a variety of issues dealing with primate vocal behavior and the neurobiology of the primate auditory system. The synthesis of ethological and neurobiological approaches to primate vocal behavior presented in this book yield a rich understanding of the acoustic and neural bases of primate audition and shed light on the evolutionary precursors to speech. Catalog no. 0956, ISBN: 978-0-8493-0956-4 August 2002, 6-1/8 x 9-1/4, 336 pp. Suggested Price: $159.95 / £99.00

Edited by

The Primate Visual System

Manuchair Ebadi

Edited by

University of North Dakota, Grand Forks, USA

Jon H. Kaas and Christine E. Collins

Ronald F. Pfeiffer

Vanderbilt University, Nashville,Tennessee, USA Series: Frontiers in Neuroscience, 20

University of Tennessee Health Science Center, Memphis, USA

A new optimism that Parkinson’s disease can be defeated has been energizing the research community. Halting the progression of the disease, restoring function, and even prevention are all realistic goals. This comprehensive volume provides information on all aspects of Parkinson’s disease, including epidemiology, genetics, diagnosis, treatment, and social issues. Novel and attractive models are included to simplify difficult-to-understand concepts. With a focus on therapeutics, Parkinson’s Disease emphasizes both the importance of early diagnosis and the search for more effective therapies. Catalog no. 1590, ISBN: 978-0-8493-1590-9 December 2004, 8-1/2 x 11, 1080 pp. Suggested Price: $229.95 / £146.00

Pediatric Epilepsy Case Studies From Infancy and Childhood through Adolescence

Discussing the neural behavior of visuomotor processing in the primate brain, this book synthesizes current knowledge on the anatomical and functional organization of the primate visual system and proposes new directions for research. It describes state-of-the-art methods for investigating the visual system and includes coverage of how the visual system is formed during development. With contributions by a multidisciplinary group of leading researchers, the book considers a range of topics concerning various primates, including humans, and covers processing from the eye to neural codes for action, and from basic perception to memory. Catalog no. 1243, ISBN: 978-0-8493-1243-4 July 2003, 6-1/8 x 9-1/4, 440 pp. Suggested Price: $149.95 / £95.00

Sleep Circuits and Functions

Edited by

Kevin Chapman and Jong M. Rho

Pierre-Hervé Luppi

Barrow Neurological Institute, Phoenix, Arizona, USA

University of Lyon, France

The amount of information currently available on pediatric epilepsy, as with all burgeoning fields, can seem overwhelming. This book reviews new information on the pathophysiology, genetics, and treatment of the various epilepsy syndromes and distills it into an easy-to-use guide. The book provides brief, but thorough descriptions of the different syndromes encountered in clinical practice across the pediatric range. The extensive resource section provides an authoritative guide to relevant findings scattered in the literature, making the book a concise and practical reference for health professionals in training.

This comprehensive book discusses the major discoveries related to the circuits responsible for slow wave sleep (SWS), rapid eye movement (REM) sleep, narcolepsy, and the possible role of sleep in memory and developmental processes. It also presents recent advances in sleep research obtained by means of emerging technologies. Sleep: Circuits and Functions includes data obtained by differential gene expression analysis, transgenic mice, and functional imaging as well as theoretical concepts on the mechanisms regulating sleep.

Catalog no. 83422, ISBN: 978-1-4200-8342-2 September 2008, 6-1/8 x 9-1/4, 296 pp. Suggested Price: $79.95 / £49.99

Catalog no. 1519, ISBN: 978-0-8493-1519-0 September 2004, 240x160, 272 pp. Suggested Price: $149.95 / £95.00

Neuroscience

Edward D. Levin

Ethology and Neurobiology

For more information and a complete list Translational Pain Research The Somatosensory System Deciphering the Brain’s Own Body Image

Edited by

Lawrence Kruger

Neuroscience

Edited by

University of California, Los Angeles, USA

Randall J. Nelson

Alan R Light

University of Tennessee, Memphis, USA Series: Frontiers in Neuroscience, 11

University of Utah, Salt Lake City, USA Series: Frontiers in Neuroscience, 43

Exploring new and past research in the understanding of how the brain deals with its own body image, this book provides a review of pertinent literature and offers comprehensive descriptions of technical approaches. The material includes frameworks for the conceptualization of the system’s representations, scientific and clinical applications that stem from these approaches based on the concepts, and a discussion of tools used to study the interface of the brain and the body. The book provides computational strategies for sensorimotor integration of the mammalian brain and includes algorithms for the design and implementation of haptic interfaces and tactile displacement.

The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, this book examines rodent models for pain associated with bone cancer, osteoarthritis, and cardiac episodes. It covers the cloning of highly specific receptors and the analysis of modular molecular mechanisms relevant to painful neuropathies, while also considering the bearing of this trend toward translational research on the commercial pharmaceutical establishment.

Catalog no. 2336, ISBN: 978-0-8493-2336-2 November 2001, 6-1/8 x 9-1/4, 424 pp. Suggested Price: $149.95 / £95.00

Catalog no. K10609, ISBN: 978-1-4398-1209-9 November 2009, 6-1/8 x 9-1/4, 432 pp. Suggested Price: $159.95 / £99.00

The Superior Colliculus New Approaches for Studying Sensorimotor Integration Edited by

Traumatic Brain Injury

Duke University, Durham, North Carolina, USA

Methods for Clinical and Forensic Neuropsychiatric Assessment, Second Edition

Adonis K. Moschovakis

Robert P. Granacher, Jr.

William C. Hall

From Mouse to Man

University of Crete, Heraklion, Greece

University of Kentucky, Lexington, USA

Presenting information amassed from more than 30 years of research, this book gathers together the most important pieces of evidence regarding the structure and function of the superior colliculus. It explores the involvement of the superior colliculus in the control of gaze shift and rapid eye movements and provides a detailed discussion of structural features as they relate to functional properties. Placing empirical data in the context of theory, the editors use computational models of the superior colliculus as scaffolds around which to organize psychophysical, neurological, anatomical, and physiological findings concerning its involvement in orienting movements.

A comprehensive introduction to evaluating and treating patients with traumatic brain injuries, this second edition of a bestseller features updated information regarding the epidemiology and pathophysiology of brain injury. It also discusses structural and functional imaging in the assessment of traumatic brain injury, including functional MRI, PET scanning, and magnetic resonance spectroscopy. With expanded discussions of brain-injury malingering and family dynamics, this revised text gives an overview of state-of-the-art techniques and discusses pharmacological treatments, acquired psychopathy, and test instruments for assessing behavior.

Catalog no. 0643, ISBN: 978-0-8493-0097-4 September 2003, 240x160, 344 pp. Suggested Price: $159.95 / £99.00

Catalog no. 8138, ISBN: 978-0-8493-8138-6 December 2007, 7 x 10, 584 pp. Suggested Price: $149.95 / £95.00

The Third Histamine Receptor

Traumatic Brain Injury

Selective Ligands as Potential Therapeutic Agents in CNS Disorders

Rehabilitation, Treatment, and Case Management, Third Edition

Edited by

Divya Vohora

Mark J. Ashley

Hamdard University, New Delhi, India

Centre for Neuro Skills of California, Bakersfield, USA

Since their discovery, the potential of histamine H3 receptor ligands in various CNS disorders have received much attention. This resource presents recent advances with an emphasis on pharmacology. It covers identification and localization of receptors and the development of novel ligands incorporating pre-clinical and clinical studies indicating earliest possible stages of development. The book provides an overview of histamine as a neurotransmitter and discusses receptor pharmacology, signal transduction, and therapeutic potential. Several chapters address disorders involving H3, including Alzheimer’s, ADHD, sleep disorders, epilepsy, obesity, and psychiatric and neurodegenerative disorders.

The new edition of this highly respected text explores advances in specific therapeutic approaches and other key information that is otherwise available only through multiple sources. It offers pharmacological, anatomical, and physiological information for basic therapeutic rationales that are not well understood in the field. Widening coverage from the last edition, it includes details on metabolic factors in brain injury, neuroendocrine dysfunction following brain injury, biomechanical assessment of traumatic brain injury, radiologic advances, and neuropharmacological and neuropsychological interventions following brain injury.

Catalog no. 53922, ISBN: 978-1-4200-5392-0 November 2008, 6-1/8 x 9-1/4, 400 pp. Suggested Price: $159.95 / £99.00

Catalog no. 71947, ISBN: 978-1-4200-7194-8 May 2010, 7 x 10, 1040 pp. Suggested Price: $159.95 / £99.00

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Understanding Autism Edited by

Bioactive Peptides

University of Southern California, Washington, D.C., USA

Applications for Improving Nutrition and Health

John L. R. Rubenstein

Richard Owusu-Apenten

Steven O. Moldin University of California, San Francisco, USA

University of Ulster, Coleraine, Northern Ireland

Integrating basic and clinical neuroscience perspectives, Understanding Autism: From Basic Neuroscience to Treatment presents a comprehensive perspective on current autism research including epidemiology, genetics, and clinical neuroscience and neural systems. An underlying theme focuses on future genomic research, and the text also explores social, economic, and advocacy issues, stimulating new directions for research and the development of new drug treatment. The authoritative strength of this work is destined to move autism research into its rightfully prominent place in modern medicine.

Recent studies show that bioactive peptides enhance the body’s antioxidant status, antisepsis capacity, immune function, anti-inflammatory capacity, mineral absorption, and appetite. Presenting data from human studies and trials, along with recent research findings, this work summarizes the applications, and benefits of bioactive peptides used to mitigate major metabolic derangements arising from chronic illnesses and resulting in unwanted weight loss. This book covers general principles, such as host response, quality factors, protein economics, and muscle loss. It also includes case studies on aging, AIDS, COPD, diabetes, inflammatory bowel disease, kidney failure, and tuberculosis.

Catalog no. 2732, ISBN: 978-0-8493-2732-2 April 2006, 6-1/8 x 9-1/4, 552 pp. Suggested Price: $175.95 / £111.00

Catalog no. K10702, ISBN: 978-1-4398-1362-1 February 2010, 6-1/8 x 9-1/4, 440 pp. Suggested Price: $169.95 / £108.00

Biotechnology in Functional Foods and Nutraceuticals Adipose Tissue and Inflammation

Edited by

University of Houston, Texas, USA

Atif B. Awad and Peter G. Bradford

Francis C. Lau

State University of New York, Buffalo, USA Series: Oxidative Stress and Disease, 27

InterHealth Nutraceuticals Incorporated, Benicia, California, USA

Obesity leads to a host of pathologies, including cardiovascular disease, insulin resistance, and metabolic syndrome. Central to all of these pathologies is the concept that obesity produces chronic inflammation. Featuring contributions from experts in the fields of adiposity, inflammation, adipokines, and pharmaconutrition, this book focuses on the effects of obesity on systemic inflammation. The text addresses the epidemiology of obesity-induced inflammation, the adipokine mediators that link adipose tissue to inflammation, the influence of hormones on adipose inflammation, and the roles of nutrients, lifestyles, and pharmacotherapy in reducing inflammation and obesity. Catalog no. 91301, ISBN: 978-1-4200-9130-4 October 2009, 6-1/8 x 9-1/4, 318 pp. Suggested Price: $149.95 / £95.00

Textbook

Advanced Nutrition

Debasis Bagchi

Dilip K. Ghosh nutriConnect, Sydney, NSW, Australia

In this volume, top-tier researchers and scientists provide a review of current developments on biotechnology in the food and nutraceuticals industries. The contributors describe state-of-the art procedures for genetic engineering of functional foods, applications of marine and animal biotechnology in nutrition, enhancement of bioactive phenolic metabolites, safety considerations of probiotics, and biotechnology to increase the bioavailability of phytonutrients. Additional topics include the improvement of nutritional value in functional foods, food manufacturing technology, quality assurance, and the legal, social, and regulatory aspects of food and nutrition biotechnology. Catalog no. 87118, ISBN: 978-1-4200-8711-6 April 2010, 7 x 10, 544 pp. Suggested Price: $149.95 / £95.00

Textbook

Macronutrients, Micronutrients, and Metabolism

Case Studies in Physiology and Nutrition

Carolyn D. Berdanier

Lynne Berdanier

Professor Emerita, University of Georgia, Athens, USA

Gainesville State College, Georgia, USA

Janos Zempleni

Carolyn D. Berdanier

University of Nebraska, Lincoln, USA

Professor Emerita, University of Georgia, Athens, USA

Integrating nutrition with biochemistry, genetics, and physiology, this text presents key concepts in nutrition science, with emphasis on the role of macroand micronutrients in metabolism. Revising and expanding information from Advanced Nutrition Micronutrients and Advanced Nutrition Macronutrients, this work includes chapters on the regulation of food intake, daily recommendations, nutrition assessment, metabolism, toxicology, nutrigenomics, epigenetics, gene expression, cell cycle, and lifespan nutrition. It includes a glossary, clinical correlates, diagrams, and a CD-ROM with additional instructional material.

Designed to encourage critical thinking skills, this text of case studies presents a range of issues including anemia, diabetes, obesity, over- and malnutrition, starvation, parasites, dementia, and vitamin deficiencies. Each study presents patient background, lists symptoms and clinical findings, and poses questions. Another section lists solutions, scientific information, and opportunities for further learning. The text provides an understanding of nutritional components by defining biochemical, mechanical, and physical functions. Systems approaches will aid readers in relating functionality to system failure as well as understanding the role of environment in health and nutrition.

Catalog no. 55526, ISBN: 978-1-4200-5552-8 August 2008, 7 x 10, 552 pp., Soft Cover Suggested Price: $99.95 / £63.99

Neuroscience / Nutrition Science

From Basic Neuroscience to Treatment

Catalog no. 88777, ISBN: 978-1-4200-8877-9 September 2009, 7 x 10, 176 pp., Soft Cover Suggested Price: $59.95 / £38.99

For more information and a complete list CRC Desk Reference for Nutrition Second Edition

N. A. Michael Eskin University of Manitoba, Winnipeg, Canada

Nutrition Science

Carolyn D. Berdanier

Snait Tamir

Professor Emerita, University of Georgia, Athens, USA Series: Desk References

Tel-Hai Academic College, Upper Galilee, Israel Series: Functional Foods and Nutraceuticals, 8

The CRC Desk Reference for Nutrition concisely defines hundreds of terms used in nutrition science. This second edition also includes numerous additional terms and includes notable revisions along with information that facilitates data accessibility; web addresses that provide access to the extensive Table of Food Composition maintained by the USDA and the Dietary Reference Intakes that contains the most current recommendations for nutrient intakes; and listings of the many drugs that are used to manage nutrition-related conditions, such as cardiovascular disease, diabetes, hypertension, and obesity.

Health professionals recognize the role of nutraceuticals in health enhancement, however, there is much confusion and misinformation about these products and the science behind them. Dictionary of Nutraceuticals and Functional Foods is the first reference of its kind for this rapidly developing field. It provides concise, science-based information on over 470 nutraceutical and functional food products and compounds. Each entry lists the most current information on the product or compound, its role in the promotion of health or the prevention of disease, and peer-reviewed literature references. This reference also contains 172 chemical structures, 102 figures, 73 schemes, and 64 tables.

Catalog no. 3835, ISBN: 978-0-8493-3835-9 November 2005, 7 x 10, 536 pp. Suggested Price: $104.95 / £66.99

CRC Desk Reference on Sports Nutrition Mark Kern

Dictionary of Nutraceuticals and Functional Foods

Catalog no. 1572, ISBN: 978-0-8493-1572-5 December 2005, 7 x 10, 520 pp. Suggested Price: $93.95 / £59.99

Food Composition and Nutrition Tables 7th Edition Siegfried W. Souci, W. Fachmann, and Heinrich Kraut

San Diego State University, California, USA

Stuttgart, Germany

CRC Desk Reference on Sports Nutrition is the first desk reference devoted to sports nutrition. This topic-by-topic resource includes a designated range of depth for topics depending on the relative importance of the topic. A primary feature of the book is the coverage of each topic in one of the following formats: definition, paragraph, essay, composition, article, or feature article. These formats may also include figures, tables and photographs to support complex descriptions. Terms are listed in alphabetical order for easy reference and include coverage of herbs and dietary supplements, and tables summarize additional data related to defined terms.

Designed for dietitians and nutritionists, as well as food scientists, researchers, and manufacturers, this text offers the reliable current information needed to make effective nutritional decisions in the production, marketing, and control of food products. Food composition and nutrition tables presented in English, German, and French address varying nutritional requirements and allow for the constant changes in the nutritional assessment of food constituents. This edition builds on the strong base of previous editions by incorporating discussions on select new foods, investigations in bioactive compounds, and revised data on more than 800 foods and 300 constituents.

Catalog no. 2273, ISBN: 978-0-8493-2273-0 May 2005, 6-1/8 x 9-1/4, 216 pp. Suggested Price: $97.95 / £61.99

Catalog no. V9178, ISBN: 978-0-8493-4141-0 May 2008, 8-1/2 x 11, 1300 pp. Suggested Price: $199.95

Delivery and Controlled Release of Bioactives in Foods and Nutraceuticals Edited by

Nissim Garti The Hebrew University of Jerusalem, Israel

This important book reviews how to optimize delivery and controlled release systems to maximize the health-promoting properties of food products. It discusses factors affecting nutrient bioavailability and assessment methods, addresses materials and specific application techniques, and compares the benefits and drawbacks of structured lipids, micro- and nano-emulsions, food-proteinderived materials, complexes and conjugates of biopolymers, and starch. The book presents the differing parameters involved in controlled release of antioxidants, vitamins, folic acid, probiotics, fish oils, and proteins, as well as regulatory issues and future trends in bioactives and nutraceuticals. Catalog no. WP7436, ISBN: 978-1-4200-7436-9 February 2008, 6-1/8 x 9-1/4, 384 pp. Suggested Price: $279.95 / £147.00

Food Constituents and Oral Health Current Status and Future Prospects Edited by

Michael Wilson Clemson University, South Carolina, USA and Eastman Dental Institute, UK

Oral diseases can have a significant impact on self esteem and quality of life. This essential collection reviews the latest research into the effects of food constituents on diseases and conditions of the mouth. Chapters cover diseases caused by oral bacteria, viral and fungal infections of the oral cavity, and dental erosion. The book also examines the effects of specific foods and food components, including sugar alcohols, casein phosphopeptides, and antioxidants. The final section explores the technology and development of foods and supplements for oral health and oral healthcare products containing food-derived bioactives. Catalog no. N10062, ISBN: 978-1-4398-0430-8 June 2009, 6 x 9, 500 pp. Suggested Price: $247.95 / £150.00

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Food Lipids

Handbook of Nutrition and Food

Chemistry, Nutrition, and Biotechnology, Third Edition

Second Edition Edited by

Edited by

Carolyn D. Berdanier

The University of Georgia, Athens, USA

David B. Min The Ohio State University, Columbus, USA Series: Food Science and Technology, 117

Highlighting the role of dietary fats in foods, human health, and disease, the third edition of Food Lipids emphasizes lipids from the point of entry into the food supply. New chapters cover polyunsaturated lipid oxidation in aqueous systems, total antioxidant evaluation and synergism, tocopherol stability and prooxidant mechanisms of oxidized tocopherols in lipids, and the effects and mechanisms of minor compounds in oil-on-lipid oxidation. Addressing the chemistry of lipid and antioxidant reactions as well as applications in biotechnology, this edition presents an in-depth discussion on lipid oxidation and antioxidants, with references throughout the text. Catalog no. 46632, ISBN: 978-1-4200-4663-2 March 2008, 7 x 10, 928 pp. Suggested Price: $239.95 / £152.00

Functional Foods Principles and Technology

Professor Emerita, University of Georgia, Athens, USA

Johanna Dwyer Tufts New England Medical Center, Boston, Massachusetts, USA

Elaine B. Feldman Professor Emerita, Medical College of Georgia, Augusta, USA

Extensively revised and updated, the Handbook of Nutrition and Food, Second Edition covers basic nutrition concepts including food composition, labeling, and nutrient analysis systems to provide a solid foundation for understanding the role of individual micronutrients, metabolic issues, and nutrient-nutrient interactions and their effects on the body. Researchers address nutritional need throughout the lifecycle from pre-natal to old age, as well as the nutritional evaluation and monitoring of specific age and cultural demographics. A considerable portion of the book details clinical nutrition and the prophylactic and therapeutic use of nutrition in a wide variety of disease circumstances. Catalog no. 9218, ISBN: 978-0-8493-9218-4 August 2007, 8-1/2 x 11, 1288 pp. Suggested Price: $299.95 / £191.00

Handbook of Nutrition in the Aged Fourth Edition Edited by

Edited by

Ronald Ross Watson

M. Guo University of Vermont, USA

University of Arizona, Tucson, USA Series: Modern Nutrition

Functional foods — products which have health-promoting properties over and beyond their nutritional value — have become a significant food industry sector. This volume provides an authoritative introduction to the key scientific aspects and major product categories in this area. Focusing on the most significant products, it reviews ingredient sources, classification, chemical and physical properties, and the wide range of therapeutic effects and possible mechanisms of action. It also explores industry and consumer roles and examines antioxidants, dietary fiber, prebiotics and probiotics, lipids and soy. The Appendix provides laboratory exercises to test comprehension.

The Handbook of Nutrition in the Aged reviews health problems that occur in aging adults and the nutritional therapies to overcome them. This fourth edition features sections on alcohol and beverages in health degradation as well as complementary and alternative medicines, including the use of antioxidants, botanicals, and marine oils. The book addresses arthritis, cognitive functioning, diabetes prevention, cancer, nutritional supplements in fracture care, and recent research on protein and vitamins intake. This text also provides information on adequate diets for the aging, undernutrition, longevity, disease prevention, and nutritional supplements to improve quality of life.

Catalog no. N10083, ISBN: 978-1-4398-0897-9 February 2009, 6 x 9 Suggested Price: $229.95 / £135.00

Catalog no. 59718, ISBN: 978-1-4200-5971-7 October 2008, 7 x 10, 368 pp. Suggested Price: $129.95 / £82.00

Geriatric Nutrition Edited by

John E. Morley and David R. Thomas

Handbook of Prebiotics Edited by

Glenn R. Gibson The University of Reading, UK

Saint Louis University School of Medicine, Missouri, USA Series: Nutrition and Disease Prevention

Marcel B. Roberfroid

Geriatric Nutrition ties basic research with clinical practice in a state-of-the-art review of current nutritional thinking. Beginning with an overview of nutrition in older persons, the book addresses nutritional requirements, techniques for the clinical assessment of nutrition in older adults, and the management of undernutrition in nursing homes and assisted living environments. A significant portion of the book covers nutrition recommendations for specific disease states, including psychological disorders, obesity, diabetes, cancer, anemia, and those associated with fracture risk. The book also considers multicultural and ethical issues relevant to the sensitive treatment of older individuals.

Presenting a balanced view of the current knowledge in many different areas of the field, this handbook discusses the concept, definition and criteria for classification as prebiotics and describes their interactions with gut microbiota. It examines the biomechanics of prebiotics and their effects on immune status, serum lipid concentrations, mineral bioavailability, and satiety modulation. It considers the health implications of prebiotic intake and explores the varying effects of prebiotics in different populations and age groups. It also describes potential food avenues and the safety implications for prebiotic use.

Catalog no. 3815, ISBN: 978-0-8493-3815-1 May 2007, 6-1/8 x 9-1/4, 600 pp. Suggested Price: $144.95 / £92.00

Nutrition Science

Casimir C. Akoh

Université Catholique de Louvain, Brussels, Belgium

Catalog no. 8171, ISBN: 978-0-8493-8171-3 January 2008, 6-1/8 x 9-1/4, 504 pp. Suggested Price: $149.95 / £95.00

For more information and a complete list Handbook of Prebiotics and Probiotics Ingredients Health Benefits and Food Applications Edited by

Susan Sungsoo Cho

A Clinical Guide

Nutrition Science

NutraSource Inc., Maryland, USA

Edited by

Terry Finocchiaro National Starch Food Innovation, Bridgewater, New Jersey, USA

Laura E. Matarese, Ezra Steiger, and Douglas L. Seidner

While there is little dispute that probiotics and prebiotics, alone and together, have been proven to promote gastrointestinal health and proper immune function, the challenge faced by researchers is finding not only the right combinations, but also finding those that are fully compatible with the formulation, processing, packaging, and distribution of functional foods. This volume comprehensively explores these variables and highlights the most current biological research and applications. It examines the sources of prebiotics and probiotics, describes the physiological functions of both products, and discusses promising applications for a plethora of disorders.

The introduction of parenteral nutrition support has given patients with short bowel syndrome the time they need to achieve maximal intestinal rehabilitation and has allowed these patients to survive. The pioneering work of Drs. Byrnes and Wilmore in the 1990s focused on novel techniques to enhance intestinal adaptation and absorption, including modification of diet, special nutrients, oral rehydration solutions, growth factors, and surgical techniques. Intestinal Failure and Rehabilitation: A Clinical Guide brings together an expert group of clinicians to help us understand current information regarding the prevention, diagnosis, care, and management of patients with intestinal failure.

Catalog no. 62131, ISBN: 978-1-4200-6213-7 November 2009, 6-1/8 x 9-1/4, 454 pp. Suggested Price: $159.95 / £99.00

Catalog no. 1803, ISBN: 978-0-8493-1803-0 October 2004, 241x164, 424 pp. Suggested Price: $144.95 / £92.00

Textbook

Handbook of Vitamins

Intestinal Failure and Rehabilitation

Introduction to Cereal Grains

Fourth Edition

Properties, Processing, and Nutritional Attributes

Edited by

Sergio O. Serna-Saldivar

Robert B. Rucker, Janos Zempleni, John W. Suttie, and Donald B. McCormick

I.T.E.S.M., Monterrey, Mexico Series: Food Preservation Technology

Thoroughly revised and updated, Handbook of Vitamins highlights the most recent research in vitamins and gene expression, vitamin-dependent genes, and vitamin effect on DNA stability. This fourth edition includes chapters on vitamin-dependent modification of chromatin, analysis of vitamin metabolism using accelerated mass spectrometry, and dietary reference intakes for vitamins. It encompasses classical and modern approaches to vitamins, focusing on human nutrition, vitamin analysis, and vitamin action at the molecular level. Featuring contributions from international experts, this remains an ideal reference for nutritional scientists, food scientists, and graduate students.

Focusing on postharvest management and the wide array of industrial processes used to manufacture foods, this book provides current information about the physicochemical and nutritional properties of cereals and their products. It is organized in such a way that readers are first exposed to the chemistry, physical properties, and morphology of cereal grains in order to understand better the storage and manufacturing processes. The text covers the chemical and physical grain properties of various types of cereals and cereal-based products as well as industrial dry-milling and wet-milling techniques. Each chapter includes a set of updated references along with selected questions.

Catalog no. 4022, ISBN: 978-0-8493-4022-2 June 2007, 7 x 10, 608 pp. Suggested Price: $154.95 / £98.00

Catalog no. K10801, ISBN: 978-1-4398-1560-1 March 2010, 6-1/8 x 9-1/4, 536 pp. Suggested Price: $99.00 / £63.99

Herbal and Traditional Medicine Molecular Aspects of Health

Textbook

Edited by

University of California, Los Angeles, USA

Introduction to Nutrition and Metabolism

Choon Nam Ong and Barry Halliwell

Fourth Edition

National University of Singapore Series: Oxidative Stress and Disease, 14

David A. Bender

Responding to the increased popularity of herbal medicines and other forms of complementary or alternative medicine in countries around the world, this reference reviews and evaluates various safety, toxicity, and quality-control issues related to the use of traditional and herbal products for health maintenance and disease prevention and treatment. With over 3,550 references, the book highlights the role of herbal medicine in national health care while providing case studies of widely used herbal remedies and their effects on human health and wellness, as well as the need for the design and performance of methodologically sound clinical trials for the plethora of herbal medicines.

This fourth edition of a bestseller cuts through a wealth of conflicting new findings to continue to provide a clear introduction to nutrition and metabolism. Via basic biochemistry, it explains the scientific principles underlying our current understanding of interactions between diet and health, examines nutrient function and metabolic pathways, and explores the scientific basis of various dietary goals. Features in this edition include a list of key points at the end of each chapter and the addition of open-ended case-based problems. The accompanying CD-ROM contains PowerPoint® presentations, self-assessment exercises, a virtual laboratory, and a nutrient analysis program.

Catalog no. DK1266, ISBN: 978-0-8247-5436-5 August 2004, 6 x 9, 968 pp. Suggested Price: $249.95 / £159.00

Catalog no. 43129, ISBN: 978-1-4200-4312-9 July 2007, 7 x 10, 440 pp., Soft Cover Suggested Price: $67.95 / £42.99

Lester Packer

University College, London, UK

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Lipid Metabolism and Health Robert J. Moffatt

Nutrition in Public Health

Florida State University, Tallahassee, USA

Principles, Policies, and Practice

Bryant Stamford

Arlene Spark

Hanover College, Indiana, USA

Hunter College, New York City, USA

This book comprehensively explores the links between lipids and health. It offers an accessible background on basic lipodology and lipid measurement, including information on lipid/lipoprotein metabolism and the biology of atherosclerosis. It discusses medical conditions affected by lipids and lipoproteins, such as diabetes and metabolic syndromes. Several chapters are devoted to how lipoproteins are affected by lifestyle practices including diet, exercise, and tobacco use. This is the first text to address the prevention and treatment of lipoprotein abnormalities in a comprehensive way, and is an invaluable tool for nutrition scientists, researchers, and dieticians.

Nutrition plays a key role in many areas of public health, such as pre-term delivery, cancer, obesity, diabetes, and cardiovascular and renal diseases. This groundbreaking book focuses on nutrition issues in the public setting, taking into account the myriad demographic, social, and cultural issues that influence public policy. It integrates an examination of food and nutrition needs and the policies and political mechanisms that affect the delivery of quality food and nutrition services. It presents opposing views on controversial, cutting-edge issues such as conflicting interests of USDA and DHHS, legislation regarding functional foods, food labeling and health claim regulations, and school meal challenges.

Catalog no. 2680, ISBN: 978-0-8493-2680-6 December 2005, 6-1/8 x 9-1/4, 376 pp. Suggested Price: $134.95 / £86.00

Catalog no. 1473, ISBN: 978-0-8493-1473-5 May 2007, 7 x 10, 576 pp. Suggested Price: $124.95 / £79.99

Micronutrients

Nutrition, Physical Activity, and Health in Early Life

Metabolic Tuning - Prevention - Therapy

Second Edition

Uwe Gröber

Jana Paˇrízková

Stuttgart, Germany

Obesity Management Centre, Prague, Czech Republic

Emphasizing the importance of micronutrients, this pocket guide combines a handy size and clear structure, making it easy for readers to find the information they need. Part I contains summaries on 54 micronutrients, covering requirements, indications groups, dosages, side effects, and commercial preparations. Part II deals with the preventive and therapeutic use of micronutrients for all age groups as well as for 38 common disorders from acne and common colds to celiac disease. This guide gives pharmacists, physicians, and dieticians the facts they need to advise their patients with confidence.

The second edition of Nutrition, Physical Activity, and Health in Early Life analyzes longitudinal and cross-sectional data on the dietary, development, environmental, and functional factors influencing the growth and development of humans in early life stages. New chapters address the role of genetic factors as well as the prevention, consequences, and treatment of obesity. The text compares body mass index and body composition on an international scale. The presented approach combines somatic, functional, biochemical, hormonal, and psychological parameters to characterize development.

Catalog no. N10088, ISBN: 978-3-8047-5039-5 December 2008, Soft Cover Suggested Price: $69.95

Catalog no. 82310, ISBN: 978-1-4200-8231-9 October 2009, 6-1/8 x 9-1/4, 428 pp. Suggested Price: $139.95 / £89.00

Nutrients and Epigenetics

Nutritional Concerns in Recreation, Exercise, and Sport

Edited by

Sang-Woon Choi

Edited by

Jean Mayer USDA Human Nutrition Research Center on Aging, Boston, Massachusetts, USA

Judy A. Driskell

Simonetta Friso

Ira Wolinsky

University of Nebraska, Lincoln, USA

University of Verona School of Medicine, Italy

Professor Emeritus, University of Houston, Texas, USA

Presenting up-to-date research on the relationship between nutrition and the evolving field of epigenetics, this work takes a close look at current findings and the potential impact of this research on our understanding of aging, embryonic growth, and the development of cancer. With the aid of numerous color illustrations and photographs, it effectively describes how nutrients modulate physiologic and pathologic processes. Providing a starting point for further research, it covers a range of cutting-edge topics that include current findings on DNA methylation, histone modification, and chromatin remodeling. It also details methods to measure epigenetic phenomena.

Concise, current, and well-referenced, this book addresses major nutritional concerns of athletes, fitness practitioners, and serious recreationalists. It contains a blend of basic and applied chapters that provide recommendations to increase endurance and enhance performance. Topics include energy requirements, the roles of macronutrients and micronutrients, hydration, weight control, dietary supplements as ergogenic aids, and the life cycle including aging and pregnancy. Information on nutrient requirements is correlated with age and energy expenditure, encouraging the creation of tailored nutrition plans. Each chapter summarizes practical nutritional recommendations.

Catalog no. 63545, ISBN: 978-1-4200-6354-7 May 2009, 6-1/8 x 9-1/4, 258 pp. Suggested Price: $129.95 / £78.99

Catalog no. 68156, ISBN: 978-1-4200-6815-3 June 2009, 6-1/8 x 9-1/4, 368 pp. Suggested Price: $119.95 / £72.99

Nutrition Science

Edited by

For more information and a complete list Nutritional Management of Digestive Disorders Edited by

Bhaskar Banerjee

Nutrition Science 28

Phytochemicals Aging and Health Edited by

Mark S. Meskin and Wayne R. Bidlack California State Polytechnic University, Pomona, USA

Washington University School of Medicine, St. Louis, Missouri, USA

R. Keith Randolph

Nutritional education and support are critical in the successful treatment of individuals with gastrointestinal disorders. This compact, practical guide provides suggestions on the management of digestive disorders with an emphasis on nutrition. Nutritionists and gastroenterologists offer practical advice and clinical insight with regard to dietary and nutritional therapeutics. Organized according to digestive anatomy, the book starts with the upper tract (esophagus), moves down the gastrointestinal tract, and covers information on ancillary organs involved in digestive disorders. An extensive appendix includes information on calories, diets, drugs, formulas, and vitamins in easy-to-read tables.

As the aging population expands, researchers are increasingly focusing on the role of nutrition, plant-based diets, and phytochemicals in healthy aging. This volume illustrates the role of phytochemicals in disease prevention, exploring their relationship to healthy aging in an effort to promote optimal health and disease prevention. The book presents information on polyphenols, flavonoid analysis, botanical therapeutics and chronic disease prevention, carotenoids and visual function, green tea and skin care, pomegranate and cardiovascular disease, nutrient-gene interactions, and personalized nutrition, with a focus on nutrigenetics as a means of nutrition therapy.

Catalog no. 86545, ISBN: 978-1-4200-8654-6 May 2010, 6-1/8 x 9-1/4, 350 pp. Suggested Price: $129.95 / £82.00

Catalog no. 61372, ISBN: 978-1-4200-6137-6 April 2008, 6-1/8 x 9-1/4, 232 pp. Suggested Price: $129.95 / £82.00

Optimizing Women’s Health through Nutrition

Phytochemicals

Edited by

Lilian U. Thompson and Wendy E. Ward University of Toronto, Ontario, Canada

Mark S. Meskin, Wayne R. Bidlack, Audra J. Davies, Douglas S. Lewis, and R. Keith Randolph

Optimizing Women’s Health through Nutrition describes recent studies on the biological and physiological differences between the sexes and describes how they may influence disease trends between men and women. The book covers the nutritional needs of women throughout the life cycle, with detailed discussions of common diseases that specifically affect women’s health. It also addresses the role of nutrition in disease risk reduction, management, and treatment. Providing suggestions for future research, the text offers key points of action by those involved in disease prevention and treatment, calling for greater attention to those conditions in which women are most vulnerable.

Backed by five decades of compelling evidence, this book addresses the roles of phytochemicals in disease prevention and health promotion. The text links diets rich in plant-derived compounds with decreased risk of chronic degenerative diseases. Chapters highlight recent developments in three areas not sufficiently covered in previous references. Pharmacokinetics and Bioavailability addresses how phytochemicals get into the body, what happens to them and how they are metabolized. Mechanisms of Action explains phytochemicals at the cellular level. Clinical Outcomes and Methodology focuses on biomarkers, as well as current and future methods that demonstrate clinical efficacy.

Catalog no. 43005, ISBN: 978-1-4200-4300-6 December 2007, 6-1/8 x 9-1/4, 472 pp. Suggested Price: $104.95 / £66.99

Catalog no. 1672, ISBN: 978-0-8493-1672-2 December 2003, 6-1/8 x 9-1/4, 224 pp. Suggested Price: $154.95 / £98.00

Oxidative Stress and Inflammatory Mechanisms in Obesity, Diabetes, and the Metabolic Syndrome

Phytochemicals

Edited by

Lester Packer University of Southern California, Los Angeles, USA

Helmut Sies Heinrich-Heine-Universitaet, Dusseldorf, Germany Series: Oxidative Stress and Disease, 23

This groundbreaking work offers a comprehensive view of the different components of metabolic stress and its association with oxidative stress and inflammation. It reports on cutting-edge research on the intracellular events mediating or preventing oxidative stress and pro-inflammatory processes in obesity and Type 2 diabetes. The book also addresses the molecular mechanisms inherent in the progression of metabolic stress and considers phenotypic perspectives, as well as dietary factors and micronutrients. This book encourages evidence-based nutritional and pharmacological therapies to attenuate the impact of obesityinduced insulin resistance and the ensuing metabolic syndrome. Catalog no. 43781, ISBN: 978-1-4200-4378-5 July 2007, 6 x 9, 344 pp. Suggested Price: $164.95 / £105.00

Access Business Group, Ada, Michigan, USA

Mechanisms of Action

Nutrient-Gene Interactions Mark S. Meskin and Wayne R. Bidlack California State Polytechnic University, Pomona, USA

R. Keith Randolph Access Business Group, Ada, Michigan, USA

This book analyzes the mechanisms of action and impact of phytochemical-gene interactions on health, aging, and disease. It covers experimental methodologies for identifying significant interactions between diet, genetic variants, and different markers of cardiovascular disease, inflammation, and obesity. It examines the role of resveratrol in cardiovascular health, the preventative mechanisms of whole grains and omega-3 fatty acids, epidemiological research on plant-based foods, the non-antioxidant cellular properties of vitamin E, and controlled clinical trials. It also explores the role of nutrigenomics in developing safe and effective phytochemical products. Catalog no. 4180, ISBN: 978-0-8493-4180-9 February 2006, 6-1/8 x 9-1/4, 232 pp. Suggested Price: $144.95 / £92.00

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Phytochemicals in Nutrition and Health

Vitamins In Foods

Edited by

George F.M. Ball

Mark S. Meskin, Wayne R. Bidlack, Audra J. Davies, and Stanley T. Omaye

Wembley, UK Series: Food Science and Technology, 156

Supported by solid scientific research, Phytochemicals in Nutrition and Health explores the mechanisms of action associated with beneficial phytochemical groups. It examines new areas such as the efficacy and safety of medicinal herbs, the use of biotechnology to manipulate and enhance the phytochemical profiles of various plants, and the pharmacokinetics of phytochemicals in humans. The editors explore new research on phytochemicals in the Vaccinium family (cranberries, blueberries and bilberries), wine, and oilseeds, and the biological activity of Echinacea in humans.

Vitamins in Foods: Analysis, Bioavailability, and Stability presents information on vitamin chemistry, absorption, and metabolism. The first section discusses the effects of food processing on vitamin retention, the physiology of vitamin absorption, and the physiochemical properties of individual vitamins. Factors affecting vitamin bioavailability are also discussed, including the development of suitable analytical methods. The second section describes the principles of analytical methods and provides detailed methods for depicting individual vitamins in foods. It includes discussion of vitamin stability from post-harvest handling to meal preparation. Catalog no. DK4945, ISBN: 978-1-57444-804-7 November 2005, 6 x 9, 824 pp. Suggested Price: $209.95 / £134.00

Vitamin Analysis for the Health and Food Sciences Second Edition Ronald R. Eitenmiller The University of Georgia, Athens, USA

Lin Ye The Coca-Cola Company, Atlanta, Georgia, USA

Application of Solution Protein Chemistry to Biotechnology Roger L. Lundblad

W. O. Landen, Jr.

Lundblad Biotechnology, Chapel Hill, North Carolina, USA

Consultant, Lavonia, Georgia, USA

Relying upon his broad view of biotechnology, pioneering protein scientist Roger Lundblad draws from both traditional protein science and proteomics to include a great deal of material not found in electronic format. He includes chapters on the use of classical protein chemistry in food, the protein and carbohydrate chemistry of adhesives, glues, and sealants, protein chemistry and hydrogels, and the use of chemical modification to prepare protein therapeutics. While demonstrating current uses and development of biotech applications, Dr. Lundblad makes a point to separate what is truly new from that which has merely been renamed. Ultimately, he provides time-saving research on which others can build.

Employing a uniform, easy-to-use format, this second edition explores methods of vitamin analysis applicable to foods, supplements, and pharmaceuticals. Highlighting the rapid advancement of vitamin assay methodology, the book emphasizes the use of improved and sophisticated instrumentation, including the widely adopted LC-MS. Designed as a bench reference, this volume covers basic chemistry and biochemistry and discusses available analytical techniques, emphasizing regulatory methods and advanced methods of current significance. It also supplies insight into practical problem solving involving the stability of vitamins and their extraction from different biological matrices. Catalog no. 9771, ISBN: 978-0-8493-9771-4 December 2007, 7 x 10, 664 pp. Suggested Price: $154.95 / £98.00

Catalog no. 73419, ISBN: 978-1-4200-7341-6 May 2009, 6-1/8 x 9-1/4, 456 pp. Suggested Price: $169.95 / £103.00

Computational ProteinProtein Interactions Edited by

Vitamin K in Health and Disease John W. Suttie

Nutrition Science / Protein Science

Catalog no. TX838, ISBN: 978-1-58716-083-7 March 2002, 6-1/8 x 9-1/4, 224 pp. Suggested Price: $144.95 / £92.00

Analysis, Bioavailability, and Stability

Ruth Nussinov National Cancer Institute, Frederick, Maryland, USA

Gideon Schreiber

Professor Emeritus, University of Wisconsin-Madison, USA

Weizmann Institute of Science, Rehovot, Israel

Studied since the 1930s, Vitamin K is a fat-soluble vitamin available primarily in vegetable sources. Vitamin K in Health and Disease provides a comprehensive summary of the latest scientific evidence regarding Vitamin K’s health-promoting activities. This book offers complete coverage of the chemistry of Vitamin K, deficiency signs and nutritional assessment, metabolism and biochemistry, and pharmacology. It presents up-to-date scientific studies on the nutritional, metabolic, and medical aspects along with an overview of the history of Vitamin K research. This text also reviews current dietary requirements and discusses both plasma and non-plasma Vitamin K-dependent proteins.

A description of fundamental and applied aspects of the usefulness of computations when approaching protein-protein interactions, this book incorporates different views of the same biochemical problem from sequence to structure to energetics. It covers protein-protein interaction, drug design for inhibition, and uses for predicting function. The text provides an overview of the topic with general chapters understandable by students and junior researchers in this area, while also providing advanced material for more specialized readers. The chapters detail the complexity of protein interaction studies and inform readers of the potential caveats that might be involved.

Catalog no. 3392, ISBN: 978-0-8493-3392-7 April 2009, 6-1/8 x 9-1/4, 231 pp. Suggested Price: $129.95 / £78.99

Catalog no. 70053, ISBN: 978-1-4200-7005-7 June 2009, 6-1/8 x 9-1/4, 343 pp. Suggested Price: $119.95 / £72.99

For more information and a complete list Textbook

Computational Proteomics Protein Classification and Meta-Organization

Food Safety of Proteins in Agricultural Biotechnology

Protein Science

Golan Yona

Edited by

Cornell University, Ithaca, New York, USA Series: Chapman & Hall/CRC Mathematical & Computational Biology

Bruce G. Hammond Monsanto Company, St. Louis, Missouri, USA Series: Food Science and Technology

Focusing on protein classification and meta-organization, Computational Proteomics describes detailed methods for detecting self-organization in complex biological systems. The book presents the analysis of biological entities and their cellular counterparts and discusses methods for detecting the building blocks of proteins and for prediction and analysis of protein-protein interactions, expression data analysis, and pathway analysis. It also examines protein space and prediction of protein function. This book includes chapters on the analysis of protein-related data types as well as special chapters on Bayesian networks and their application to the protein space.

This comprehensive reference addresses how toxicology testing of proteins can best be accomplished. It discusses protein biology and delineates the fundamental differences that impact their safety assessment. It reviews the insectprotected Bt crops, the safety assessment process developed for enzymes, protein pharmaceuticals, the challenges of testing protein therapeutics in humans, and the use of bST in dairy cows to increase milk production. The book provides sources of food consumption databases, four case studies, a final summary chapter distilling the previous information, and an overall strategy for the safety assessment of new products under development.

Catalog no. C5556, ISBN: 978-1-58488-555-9 April 2010, 6-1/8 x 9-1/4, 356 pp. Suggested Price: $79.95 / £49.99

Catalog no. 3967, ISBN: 978-0-8493-3967-7 November 2007, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $164.95 / £105.00

Textbook

Electron Transfer Proteins A Computational Perspective Toshiko Ichiye

Introduction to Peptides and Proteins Ülo Langel, Benjamin F. Cravatt, Astrid Gräslund, Gunnar von Heijne, Tiit Land, Sherry Niessen, and Matjaž Zorko

Georgetown University, Washington, DC, USA

University of Ljubljana, Slovenia

A molecular grasp of electron transfer is crucial to understanding the molecular basis of metabolic processes in which electron transfer is essential, diseases involving these processes, and drug design targeting these processes. This book provides a cohesive and comprehensive discussion of computational methods used for electron transfer proteins and what has been learned from such studies. It also offers an overview of results from theory, computation, and experiment about electron transfer proteins. Also included are strategies for studying metal sites that have not been examined computationally.

Offering a thorough presentation of peptide and protein chemistry, this volume provides key insight into the fast-developing field of proteomics, including structural and functional aspects, biochip development, and clinical potential. It includes chapters on bioinformatics and proteomics and presents the latest information on concerns over protein degradation and the post-translational modifications of proteins and peptides. The book also includes a section on protein-coupled diseases that presents increasing evidence of the pathological impact of protein misfolding in relation to various neurodegenerative diseases, as well as a section on the role of proteins in cancer.

Catalog no. 82299, ISBN: 978-1-4200-8229-6 June 2010, 6-1/8 x 9-1/4, 264 pp. Suggested Price: $119.95 / £76.99

Catalog no. 64126, ISBN: 978-1-4200-6412-4 November 2009, 6-1/8 x 9-1/4, 420 pp. Suggested Price: $99.95 / £60.99

Emerging Protein Biotherapeutics

Medicinal Protein Engineering

Edited by

Iqbal S. Grewal

Yury E. Khudyakov

Preclinical Therapeutics, Seattle Genetics, Inc., Bothell, Washington, USA

Division of Viral Hepatitis, National Center for Infectious Diseases, CDCP, Atlanta, Georgia, USA

Given the speed at which antibody therapy is becoming readily accepted, a comprehensive industry guide is sorely needed. Written by leading international authorities, this book maintains an overall emphasis on various therapeutic approaches and applications and provides critical discussions on the most significant areas of research in biologics. It focuses on the applications of protein biologics in autoimmunity and inflammation, hematological malignancies, and solid tumors. Each chapter clearly presents the most informative and contemporary account of its subject available, making this an unrivaled reference source beneficial to those in both academia and biotechnology industries.

Medicinal Protein Engineering provides a comprehensive overview of one of the most complex areas of molecular research. Using a multidisciplinary approach, the book moves readers from experiment and theory to actual applications. In particular, the text focuses on cutting-edge research in protein engineering and medicinal applications of engineered proteins. It discusses computational approaches to protein design and explores the strong connection between protein and genetic engineering. It also considers those medicinal proteins that could be improved through protein engineering, including antibodies, antigens, and a variety of vaccines.

Catalog no. 63200, ISBN: 978-1-4200-6320-2 June 2009, 6-1/8 x 9-1/4, 368 pp. Suggested Price: $159.95 / £97.00

Catalog no. 7368, ISBN: 978-0-8493-7368-8 December 2008, 7 x 10, 584 pp. Suggested Price: $179.95 / £114.00

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

Edited by

Renata Pasqualini and Wadih Arap University of Texas, M.D. Anderson Cancer Center, Houston, USA Series: Drug Discovery Series, 12

On the cutting edge of the latest research, Protein Discovery Technologies provides comprehensive coverage of the principles, techniques, strategies, and broad range of applications of protein discovery. This volume presents in-depth discussions of various methods for protein discovery, including bioinformatics, interaction cloning, protein purification, phage display, non-primate models, and chemical targeting. It also explores biological themes through the examination of cell death, angiogenesis, hemostasis, development, signal transduction, transcriptional control, cell cycle control, neurobiology, and quality control. Catalog no. DK2081, ISBN: 978-0-8247-5468-6 July 2009, 6-1/8 x 9-1/4, 250 pp. Suggested Price: $149.95 / £95.00

Protein Engineering and Design Edited by

Structure and Function of Intrinsically Disordered Proteins Peter Tompa Hungarian Academy of Sciences, Budapest, Hungary

Providing the first focused and detailed treatment of the rapidly emerging field of protein disorder, this book illustrates how IDPs defy the structure-function paradigm and play important regulatory and signaling roles. The author introduces basic terms and fundamental principles of protein science and presents a unified theory of ordered and disordered proteins. He also outlines new applications of traditional biophysical and bioinformatic techniques, such as x-ray crystallography and NMR. The book includes an overview of the structure, function, and evolution of IDPs and addresses biomedical implications and protein disorder in drug development for cancer and neurodegenerative diseases. Catalog no. C7892, ISBN: 978-1-4200-7892-3 November 2009, 6-1/8 x 9-1/4, 359 pp. Suggested Price: $99.95 / £63.99

Therapeutic Peptides and Proteins

State University of New York at Buffalo, USA

Formulation, Processing, and Delivery Systems, Second Edition

Jennifer R. Cochran

Ajay K. Banga

Sheldon J. Park Stanford University, California, USA

Mercer University, Macon, Georgia, USA

The emerging use of the computational design approach as a means of engineering proteins with novel functions has led to widespread usage of computational analysis in protein engineering at large. However, because the structure and function of protein molecules are coupled at the molecular level, many critical questions are left unanswered and many of the intricate design rules unclear. This book furthers understanding in this design area by using lucid description of computation’s role in protein engineering and tracing the history of protein design. In doing so, it successfully de-mystifies computational analysis, making it widely accessible to a broad audience both in academia and industry.

Reflecting the explosive growth of biotechnology medications, this edition of Therapeutic Peptides and Proteins provides hard to find information addressing therapeutic drugs made from proteins, as well as protein-based vaccines. Embracing an industrial perspective, it examines the origin of recombinant proteins, explores structural and analytical aspects, discusses protein and peptide stability, and offers a chapter on recombinant protein subunit vaccines and delivery systems. By presenting complex information in a simple style with minimal overlap, the book utilizes extensive cross-referencing to enhance its value as a resource.

Catalog no. 76582, ISBN: 978-1-4200-7658-5 September 2009, 6-1/8 x 9-1/4, 416 pp. Suggested Price: $119.95 / £76.99

Proteins

Catalog no. 1630, ISBN: 978-0-8493-1630-2 September 2005, 6-1/8 x 9-1/4, 376 pp. Suggested Price: $209.95 / £134.00

Asbestos

Energy, Heat and Signal Flow

Risk Assessment, Epidemiology, and Health Effects

Edited by

David M. Leitner

Ronald F. Dodson

University of Nevada, Reno, USA

ERI Consulting, Inc., & University of Texas at Tyler, USA

John E. Straub

Samuel P. Hammar

Boston University, Massachusetts, USA

Diagnostic Specialties Laboratory, Bremerton, Washington, USA

This comprehensive, timely volume presents state-of-the-art computational strategies for studying energy redistribution, signaling, and heat transport in proteins and other molecular machines, including nanoscale and biomolecular systems. It emphasizes the interrelations between these disparate approaches that have contributed to our understanding of energy flow in proteins and its role in protein function. By defining the forefront of research in this area, the book delineates the current challenges and opportunities in developing novel methods and applications for the evolving study of energy flow in molecular machines and nanomaterials.

While there are hundreds of books available on many different aspects of asbestos, none contain the encyclopedic, comprehensive coverage found in this book. With contributions from specialists and leaders in their respective fields, this volume provides a cross-disciplinary approach and an authoritative review of asbestos research. The coverage spans history, pathology, epidemiology, sampling, analysis, and regulatory issues. Offering state-of-the-art data on asbestos exposure and the resultant development of disease, the book provides coverage sufficient for specialists and researchers, but is also useful to anyone having to deal with asbestos-related problems.

Catalog no. 87037, ISBN: 978-1-4200-8703-1 September 2009, 6-1/8 x 9-1/4, 415 pp. Suggested Price: $129.95 / £82.00

Catalog no. 2829, ISBN: 978-0-8493-2829-9 September 2005, 6-1/8 x 9-1/4, 425 pp. Suggested Price: $159.95 / £99.00

Protein Science / Toxicology

Protein Discovery Technologies

For more information and a complete list The Chemical Components of Tobacco and Tobacco Smoke Alan Rodgman

Handbook of Venoms and Toxins of Reptiles

Winston-Salem, North Carolina, USA

Edited by

Thomas A. Perfetti

Stephen P. Mackessy

Toxicology

Perfetti and Perfetti, LLC, Winston-Salem, North Carolina, USA

University of Northern Colorado, Greeley, USA

Cataloging more than 8400 tobacco and tobacco smoke components, this book provides the most comprehensive, single-source reference published on the subject since 1968. It reviews every chemical class of component found in tobacco and tobacco smoke and presents more than 6000 cited references that deal with many topics pertinent to the ones in question. The authors list the corresponding Chemical Abstracts Registry Number for those most cataloged. They also examine adverse health-related problems assigned to specific tobacco smoke components as well as components reported to negate such harmful effects. The accompanying CD-ROM contains a searchable, 300-page alphabetical index.

Bringing together contributions from many of the world’s leading experts in toxinology, the Handbook of Venoms and Toxins of Reptiles covers a broad spectrum of topics relevant to a wide range of professionals including clinicians, biomedical researchers, herpetologists, and zoologists, as well as pharmacologists and evolutionary scientists. It discusses phylogeny and gland structure, venom enzymes and toxins, non-protein venom components, and envenomation and its treatment, including ideal treatments contrasted with that which is actually available in specific areas of the world. The text also addresses venom enzymes and assay procedures used to detect venoms along with venom toxins.

Catalog no. 78836, ISBN: 978-1-4200-7883-1 December 2008, 8-1/2 x 11, 928 pp. Suggested Price: $299.95 / £191.00

Catalog no. 9165, ISBN: 978-0-8493-9165-1 July 2009, 7 x 10, 528 pp. Suggested Price: $129.95 / £82.00

Endocrine Disruption Modeling Edited by

Instrumental Data for Drug Analysis

James Devillers

Third Edition - Six-Volume Set

CTIS, Rillieux La Pape, France Series: QSAR in Environmental and Health Sciences

Based on the research of an international panel of contributors from industry, academia, and regulatory agencies, this book provides an excellent overview of approaches for modeling the endocrine activity of chemicals and the related potential adverse effects they may induce on environmental and human health. It focuses on chemicals accidentally released into the environment and also on the specific design, in agro-chemistry, of chemicals acting on the endocrine system of insects to control them. An interesting feature of the book is the bringing together of these two aspects of endocrine disruption, which are based on the same modeling concepts. It includes a review of available e-resources. Catalog no. 76353, ISBN: 978-1-4200-7635-6 April 2009, 6-1/8 x 9-1/4, 416 pp. Suggested Price: $139.95 / £85.00

Terry Mills, III, James Conrad Roberson, Christian C. Matchett, Mathew J. Simon, Mark D. Burns, and Robert J. Ollis, Jr. Finding detailed information on the analysis of drug-related compounds is challenging at best. This latest edition is an extensive six-volume set that contains over 6500 spectra on more than 1750 illicit and prescription drugs. It presents data on the six most popular analytical techniques used today: ultraviolet (UV) spectroscopy, infrared (IR) spectrometry, nuclear magnetic resonance (NMR) spectrometry, mass spectrometry (MS), gas chromatography (GC), and high pressure liquid chromatography (HPLC). This edition also presents the latest analytical techniques of FT-Ramen Spectra. Drugs are alphabetized and a combined index permits easy reference. Catalog no. 1974, ISBN: 978-0-8493-1974-7 August 2005, 8-1/2 x 11, 4688 pp. Suggested Price: $1295.00 / £825.00

Jet Fuel Toxicology Mark L. Witten

Handbook of Forensic Toxicology for Medical Examiners

University of Arizona School of Medicine, Tucson, USA

D. K. Molina, M.D.

Glenn David Ritchie

Series: Practical Aspects of Criminal & Forensic Investigations, 50

Forensic professionals, often working through heavy caseloads, require quick and easy access to reliable sources of information to help interpret toxicology results. This volume is a concise handbook referencing the most common toxic drugs and their levels of toxicity, making it an ideal text for quick confirmation in the field or in the lab. It describes how to obtain and submit samples, explains methods of analysis, provides hundreds of tables and data sets on substances causing toxicity that are commonly seen in forensic practice, and includes several appendices, including one on the latest issues in pharmacogenetics pertinent to forensic investigation. Catalog no. 76418, ISBN: 978-1-4200-7641-7 July 2009, 6-1/8 x 9-1/4, 384 pp. Suggested Price: $89.95 / £57.99

Errol Zeiger NIEHS, Chapel Hill, North Carolina, USA Central Nervous System Safety Pharmacology, Columbus, Ohio, USA

This volume explores the toxic effects of JP-8 jet fuel on the pulmonary, immune, skin, and nervous systems. The book examines the history and chemistry of jet fuel, immune suppression by dermal exposure, the molecular response of the skin, evaluation of skin irritation potential, pulmonary function after exposure, and proteomic response after exposure. It discusses studies of the acute effects of jet fuels on airways in rats, and the neurobehavioral effects on humans. The book provides a comparison of Air National Guard and Air Force Personnel exposure studies to jet fuel and also contains a section on neuro-genetic responses. Catalog no. 80202, ISBN: 978-1-4200-8020-9 May 2010, 6-1/8 x 9-1/4, 512 pp. Suggested Price: $159.95 / £99.00

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Seafood and Freshwater Toxins Second Edition

Pharmacology, Physiology, and Detection, Second Edition Edited by

Edited by

Luis M. Botana

Charles L. Wilson, Ph.D. President & CEO, Wilson Associates International LLC, USA

University of Santiago de Compostela, Lugo, Spain Series: Food Science and Technology, 103

Microbial Food Contamination, Second Edition is a comprehensive evaluation of the microbiology, biochemistry, detection, risk, and threat of foodborne illness in today’s global climate. It introduces new insights into the pathogenic effect of contaminants including mycotoxins and aflatoxins. It presents recent advances in detecting and monitoring food borne human pathogens, and examines control and prevention measures including the genetic and biochemical control of aflatoxigenic fungi. Contributions discuss globalization and the increased risk for transnational contamination, the impact of food contamination on international trade, and international programs to mitigate these events.

This second edition provides an overview of the expanding scope of the field from several perspectives. Incorporating pharmacology, toxicology, chemistry, ecology, and economics, it covers several categories of toxins by function and biomechanism, potential pharmacological applications, and legal and economic perspectives. New toxins such as pfiestra, gambierol, and polycavernoside are described by their individual chemical structure, ecobiology, metabolism, detection methods, determination, pharmacology, and toxicology. Logically organized for clear understanding, this edition includes more information on the effects and actions of each toxin, detection and analysis, and food safety issues.

Catalog no. 9076, ISBN: 978-0-8493-9076-0 October 2007, 6-1/8 x 9-1/4, 632 pp. Suggested Price: $164.95 / £105.00

Catalog no. 7437, ISBN: 978-0-8493-7437-1 January 2008, 7 x 10, 960 pp. Suggested Price: $229.95 / £146.00

Textbook

Advances in Food Biochemistry

Principles of Food Toxicology Tõnu Püssa

Edited by

Fatih Yildiz

Estonian University of Life Sciences, Tartu

Middle East Technical University, Ankara, Turkey

Skillfully combining theory and applications, this volume begins with an introduction to toxicology principles at the molecular, cellular, and organism level. The author uses vivid examples to emphasize the biochemical mechanisms of toxic effects and toxic response. He demonstrates the determination of foreign substances and the evaluation of toxicity and risk analysis. The second section considers individual toxicants from plants and soils, environmental toxins, mycotoxins, marine and animal toxins, pesticide residues, food additives, and toxins that enter food during processing and storage, as well as digestion. The book also includes an extensive glossary.

Reflecting the rapid pace of discovery that has taken place over the last decade, Advances in Food Biochemistry presents a unique, up-to-date, and unified introduction to food chemistry from a biochemical standpoint. Featuring color illustrations to elucidate molecular concepts throughout the text, this book addresses the relationship between nutrition and genetics, food-environment interactions, and the regulation of contaminants, additives, herbs and dietary supplements. Coverage of recent developments includes water isotopes, bioactive lipids and carbohydrates, phytochemicals, essential oils, aroma compounds, phenolic acids, DNA traceability, nutrigenomics, and toxigenomics.

Catalog no. 8090, ISBN: 978-0-8493-8090-7 September 2007, 6-1/8 x 9-1/4, 344 pp. Suggested Price: $73.95 / £46.99

Catalog no. 7499, ISBN: 978-0-8493-7499-9 December 2009, 7 x 10, 521 pp. Suggested Price: $169.95 / £108.00

Reversibility of Chronic Degenerative Disease and Hypersensitivity

Biochemical Applications of Nonlinear Optical Spectroscopy

Volume 1 Regulating Mechanisms

Edited by

Vladislav V. Yakovlev

Environmental Health Center, Dallas, Texas, USA

University of Wisconsin, Milwaukee, USA Series: Optical Science and Engineering

The first of an encyclopedic four volume set, Volume I focuses on physiological homeostasis, the mechanism of pollutant invasion, and the possibility of reversal. Chapters address the connective tissue matrix, and the neurological, immune, and endocrine systems in detail. Distinguishing itself from previous volumes on chemical sensitivity, it explains newly understood mechanisms of chronic disease and hypersensitivity involving core molecular function. It discusses new information on ground regulation systems, genetics, the autonomic nervous system, and immune and non-immune functions. It includes new technology and treatment techniques as well as numerous color figures and supporting research.

Nonlinear optical spectroscopy is a powerful tool for studying biomolecular structures and cellular organelles. This volume presents the most significant advances and future directions within this important field. It provides an understanding of the nonlinear optical response of complex molecules and reviews developments in ultrafast technology. In addition, the editor includes a theoretical analysis of nonlinear optical spectroscopies. Novel experimental approaches, such as spatial and temporal pulse shaping, are addressed as well as various nonlinear optical spectroscopic tools, including harmonics generation and Raman spectroscopy.

Catalog no. K10689, ISBN: 978-1-4398-1342-3 March 2010, 7 x 10, 576 pp. Suggested Price: $139.95 / £73.99

Catalog no. 68598, ISBN: 978-1-4200-6859-7 June 2009, 6-1/8 x 9-1/4, 290 pp. Suggested Price: $149.95 / £89.00

William J. Rea

Toxicology / Biochemistry

Microbial Food Contamination

For more information and a complete list Carotenoids Physical, Chemical, and Biological Functions and Properties

Chitin, Chitosan, Oligosaccharides and Their Derivatives

Edited by

Biological Activities and Applications

John T. Landrum

Se-Kwon Kim

Biochemistry

Florida International University, Miami, USA

Pukong National University, Busnan, South Korea

Carotenoids are of great interest due to their essential biological functions in both plants and animals, and their properties and functions in natural systems are surprisingly complex. With an emphasis on the chemical aspects of these compounds, this text presents a broad overview and recent developments with respect to understanding carotenoid structure, electronic and photochemical properties, and the use of novel analytical methods in the detection and characterization of carotenoids and their actions. The text also explores LC/MS and LC/MS/MS techniques as well as new applications of PCR and molecular biology methodologies.

Providing comprehensive coverage of the biological activities and industrial applications of Chitin, Chitosan, Oligosaccharides, and Their Derivatives, this book presents a balance of information between the various materials, functionalities, applications, and advantages of these polysaccharides in food, nutrition, and agriculture. Divided into five parts, the first part focuses on source and production. The second, third, and fourth parts cover physical and chemical aspects, structural modifications and functions, and biological activities and mechanisms of action. The final part presents a comprehensive assessment of applications.

Catalog no. 52306, ISBN: 978-1-4200-5230-5 December 2009, 7 x 10, 562 pp. Suggested Price: $189.95 / £121.00

Catalog no. K10823, ISBN: 978-1-4398-1603-5 June 2010, 7 x 10, 496 pp. Suggested Price: $189.95 / £121.00

Textbook

Copper Amine Oxidases

Chemistry for the Life Sciences

Structures, Catalytic Mechanisms, and Role in Pathophysiology

Second Edition

Edited by

Raul Sutton and Peter G. Swindells

Giovanni Floris

University of Wolverhampton, UK

University of Cagliari, Italy

Bernard Rockett

Bruno Mondovi

Formerly of University of Wolverhampton, UK

University of Rome, La Sapienza, Italy

Retaining the user-friendly style that made the original so popular, this updated edition continues to provide a foundation in the aspects of chemistry that developing life scientists need to understand biochemical and biomedical research. This edition adds new chapters, including one on water, covering the mole concept and colloids; another on gases, discussing pressure, solubility, and diffusion; and a third on metals, describing properties, carriers, biocatalysis, and toxicity. Each topic is clearly tied to numerical considerations and core concepts. Critical information is reinforced through worked examples and questions. A solutions manual is available upon qualifying course adoption.

Although the amount of research on copper amine oxidases has grown rapidly and substantially in the past decade, the field unfortunately suffers from lack of cohesion and significant confusion surrounds aspects as simple as confirmation of enzyme identities. This book describes the structure of the enzymes, the role of copper, and the unusual cofactor 6-hydroxydopa quinine derived from a posttranslational modification of a tyrosine residue. It also covers the differences in amine oxidases from bacteria, plants, and mammals. Finally, the text examines the importance of this ubiquitous class of enzymes in physiology and in metabolism of biogenic amines.

Catalog no. 69357, ISBN: 978-1-4200-6935-8 November 2008, 7 x 10, 280 pp., Soft Cover Suggested Price: $39.95 / £25.99

Catalog no. 76809, ISBN: 978-1-4200-7680-6 June 2009, 6-1/8 x 9-1/4, 374 pp. Suggested Price: $149.95 / £89.00

Design of Caspase Inhibitors as Potential Clinical Agents Edited by

Tom O’Brien

Chemistry of Peptide Synthesis

Sunesis Pharmaceuticals, South San Francisco, California, USA

Steven D. Linton

Ottawa, Ontario, Canada

San Diego, California, USA Series: Enzyme Inhibitors Series

Chemistry of Peptide Synthesis is a complete overview of how peptides are synthesized and what techniques yield the most desirable reactions. The book encompasses all factors affecting synthesis and peptide formation. Developed from the author’s extensive teaching career, the book emphasizes learning rather than memorization. Topics include stereomutation, the applicability of coupling reactions, solid-phase synthesis, protection of functional groups, aminolysis, acidolysis, and the use of scavengers. It uses clear language and schematics to present concepts methodically and progressively, from basic theory to in-depth coverage that can be appreciated by experienced peptidologists.

Caspases (cysteine aspartyl proteases) represent one of the most specific protease families described to date. As caspase family members are involved in proinflammatory responses, inhibition of caspase activity represents a novel yet core approach to disease treatment. Design of Caspase Inhibitors as Potential Clinical Agents discusses the role of caspases in inducing cell death. It reviews recent efforts to develop small molecule inhibitors that are capable of modulating caspase activity. The text also examines the difficulties encountered in transitioning small molecule inhibitors from the lab to clinical use, and discusses how these challenges can best be overcome to allow continued progress.

Catalog no. DK3236, ISBN: 978-1-57444-454-4 August 2005, 6-1/8 x 9-1/4, 304 pp. Suggested Price: $154.95 / £98.00

Catalog no. 45407, ISBN: 978-1-4200-4540-6 October 2008, 6-1/8 x 9-1/4, 312 pp. Suggested Price: $169.95 / £108.00

N. Leo Benoiton

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Textbook

Second Edition

Insect Physiology and Biochemistry

Edited by

Second Edition

Peter M. Collins

James L. Nation

Birkbeck College, London, UK

University of Florida, Gainesville, USA

The second edition of this authoritative reference includes 3,000 additional compounds, bringing the total to 26,000. All existing entries were carefully reviewed and updated where necessary. Each entry contains chemical names and synonyms, including CAS and IUPAC names, trade names, and trivial names; full and clear description of equilibrium studies, cyclic forms, and their derivatives; extensive occurrence and use data; structure diagrams showing stereochemistry and configuration; and physical properties including melting point, optical rotation, and mutarotation data. This edition also features a structure-searchable CD-ROM providing quick, convenient access.

Based on nearly 40 years of teaching, this second edition of a bestselling text presents new findings that challenge conventional wisdom and considers their impact across species. It features updated chapters on insect immunity, insect flight, insect vision, and diapause in insects, and includes revised and additional information on insect hormones and development. Providing a clear description of the principles, fundamentals, and terminology of insect physiology, this comprehensive resource offers an in-depth discussion of the relationship between insect physiology and animal behavior and ecology. This volume contains more than 2000 references and color illustrations.

Catalog no. 3829, ISBN: 978-0-8493-3829-8 November 2005, 8-1/2 x 11, 1304 pp. Suggested Price: $519.00 / £331.00

Catalog no. 61771, ISBN: 978-1-4200-6177-2 April 2008, 7 x 10, 560 pp. Suggested Price: $79.95 / £44.99

Biochemistry

Dictionary of Carbohydrates with CD-ROM

Encyclopedia of Supramolecular Chemistry Edited by

Jerry L. Atwood

Ion-Radical Organic Chemistry

University of Missouri, Columbia, USA

Principles and Applications, Second Edition.

Jonathan W. Steed

Zory Vlad Todres

University of Durham, UK

American Chemical Society, Columbus, Ohio, USA

The Encyclopedia of Supramolecular Chemistry offers authoritative, centralized information on crystallizing, a rapidly expanding interdisciplinary field. Userfriendly, high-quality articles parse the latest supramolecular advancements and methods in the areas of chemistry, biochemistry, biology, environmental and materials science and engineering, physics, computer science, and applied mathematics. Designed for specialists and students alike, the two-volume set covers the fundamentals of supramolecular chemistry and sets the standard for relevant future research and new discoveries in this exciting area.

Consolidating knowledge from a number of disciplines, this treatise presents the recent changes that have occurred in the field since the publication of the first edition. The theme is the formation, transformation, and application of ionradicals in typical conditions of organic synthesis. Avoiding complex mathematics, the book explains the principles of ion-radical organic chemistry and presents an overview of organic ion-radical reactions. Methods of determining ion-radical mechanisms and controlling ion-radical reactions are also reviewed. Wherever applicable, issues relating to ecology and biomedical concerns are addressed, and inorganic participants of the ion-radical organic reactions are also considered.

Catalog no. DK056X, ISBN: 978-0-8247-5056-5 May 2004, 8-1/2 x 11, 1744 pp. Suggested Price: $560.00 / £357.00

Catalog no. 9068, ISBN: 978-0-8493-9068-5 October 2008, 7 x 10, 496 pp. Suggested Price: $189.95 / £121.00

Lipoic Acid Energy Production, Antioxidant Activity and Health Effects

Fundamentals of QSARs for Metal Ions John D. Walker, M. Enache, Michael C. Newman, and Costinel Lepadatu Focusing on the niche field of metal ion toxicity in Quantitative Structure Activity Relationships (QSAR), this text concentrates on the basic and essential applications of QSAR methods in metal ions for readers already familiar with the field. It delineates the theoretical basis and provides a concrete introduction to studying the biological activity and toxicity of metal ions as they impact health and the environment. The book describes the applications of QSARs in characterizing the biological activity and toxicity of metal ions and provides parameters for the correlation of structure with inorganic biological activity. It includes a CD-ROM with approximately 100 references on QSARs for metal ions. Catalog no. 8433X, ISBN: 978-1-4200-8433-7 June 2010, 6-1/8 x 9-1/4, 300 pp. Suggested Price: $139.95 / £89.00

Edited by

Mulchand S. Patel University at Buffalo, The State University of New York, USA

Lester Packer University of Southern California, Los Angeles, USA Series: Oxidative Stress and Disease, 24

Unique in its two-fold protective function, alpha-lipoic acid has drawn unprecedented interest for its role as a coenzyme in mitochondrial energy metabolism and as an antioxidant and cell redox modulator. This book covers discoveries in the chemistry, biological action, and significance of alpha-lipoic acid in energy production and health. Section I reviews the molecular structure, biosynthesis, and characterization of lipoic acid. Section II describes metabolic aspects, human pharmacodynamics, energy production, and antioxidant activity. Section III discusses clinical aspects, treatment of metabolic syndromes, and loss of mitochondrial function with lipoic acid supplementation. Catalog no. 45377, ISBN: 978-1-4200-4537-6 March 2008, 8-1/2 x 11, 556 pp. Suggested Price: $169.95 / £108.00

For more information and a complete list Molecular Basis of Chromatographic Separation Esther Forgács Hungarian Academy of Sciences, Budapest, Hungary

Second Edition CD-ROM

Tibor Cserháti

Roger L. Lundblad

Biochemistry

Hungarian Academy of Sciences, Budapest

Lundblad Biotechnology, Chapel Hill, North Carolina, USA

Chromatographic separation is widely used in many scientific disciplines today, with an ever-increasing number of scientific and technological applications. The widespread use of this rapid and powerful technique requires that it be fully understood, so that the most suitable may be determined for each possible separation problem in each possible domain of scientific research and technology. Molecular Basis of Chromatographic Separation provides complete coverage of the practical and molecular aspects of this popular technique. It compiles and evaluates recent results, outlines available methods, and discusses how to select the best method for a particular application.

Presented in a concise, logical, and easy-to-follow format, the revised and expanded second edition of the Practical Handbook of Biochemistry and Molecular Biology provides essential reference information that cannot be easily obtained from another single source. This new edition features all information on CD-ROM to offer even faster and more convenient access to the most important topics that are relevant to each reader’s needs. With physical and chemical data, this updated disk offers complete coverage of proteins, nucleic acids, lipids, carbohydrates, amino acids, peptides, vitamins, proteomics, genomics, as well as cell biology, among other critical topics.

Catalog no. 7696, ISBN: 978-0-8493-7696-2 July 1997, 7 x 10, 256 pp. Suggested Price: $229.95 / £146.00

Catalog no. 8744, ISBN: 978-0-8493-8744-9 May 2010, 1264 pp., CD-ROM Suggested Price: $159.95 / £99.00

Omega-3 Fatty Acids and the DHA Principle Raymond C. Valentine Professor Emeritus, UC Davis and Visiting Scholar, University of California, Santa Barbara, USA

Practical Handbook of Biochemistry and Molecular Biology

Textbook

Principles and Practice of Bioanalysis Second Edition Edited by

David L. Valentine

Richard F. Venn

University of California, Santa Barbara, USA

Pfizer Central Research, Kent, UK

The physical-chemical properties of the omega-3 fatty acid DHA enable it to facilitate biochemical processes in the membrane. This effect has numerous benefits, yet DHA also carries risks that can lead to cellular death and disease. This volume explores the roles of omega-3 fatty acids in cellular membranes and develops a principle by which to assess their benefits and risks. Reflecting the increased public interest that has emerged over the years, the book uses an integrative approach to explain the complex roles of omega-3s in the membrane. Incorporating principles from numerous disciplines, it gives researchers in a variety of fields the building blocks to stimulate further study.

Principles and Practice of Bioanalysis: Second Edition provides an updated guide to the techniques currently used in developing and running ultra-trace analyses for drugs, metabolites and other substances. Extensively revised, this volume reflects the dynamic growth in methodologies that has occurred over the past five years. Experts in the field offer a logical path through the problems of small molecule bioanalysis, enabling researchers to choose the appropriate methods of analysis across a number of fields, including the agrochemical and pharmaceutical industries. Scientists and graduate students in biology, biochemistry, and chemistry will also find this to be a valuable reference.

Catalog no. K10660, ISBN: 978-1-4398-1299-0 December 2009, 6-1/8 x 9-1/4, 278 pp. Suggested Price: $159.95 / £99.00

Catalog no. 3857, ISBN: 978-0-8493-3857-1 February 2008, 7 x 10, 344 pp. Suggested Price: $89.95 / £57.99 Also Available in Soft Cover

The Organic Chemistry of Sugars Edited by

Scios, Fremont, California, USA

Signaling Mechanisms of Oxygen and Nitrogen Free Radicals

Péter Fügedi

Igor B. Afanas’ev

Daniel E. Levy Hungarian Academy of Sciences, Budapest

All-Union Vitamin Research Institute, Moscow, Russia

Intrigued as much by its complex nature as by its outsider status in traditional organic chemistry, the editors of the critically acclaimed The Organic Chemistry of Sugars compile a groundbreaking resource in carbohydrate and sugar chemistry that illustrates the ease with which sugars can be manipulated in a variety of organic reactions. Presenting the organic chemistry of sugars as a solution to many complex synthetic challenges, the book focuses on reactions, including the substitution of sugar hydroxyl groups, chiral catalysis, and the syntheses of monosaccharides. It also covers the latest concepts in combinatorial carbohydrate chemistry, glycopeptides, and glycomimetics.

This volume explores major questions regarding signaling mechanisms of reactive oxygen and nitrogen species (ROS / RNS) in enzymatic processes. The text covers free radical signaling processes catalyzed by enzymes and examines those producers of superoxide and nitric oxide that are able to use produced ROS / RNS as signaling species to initiate the processes. It also considers ROS/ RNS signaling produced or insufficiently produced by mitochondrial enzymes, as well as the development of potential new treatments including novel drugs for agingrelated afflictions such inflammation, cancer, and cardiovascular disease.

Catalog no. DK3103, ISBN: 978-0-8247-5355-9 September 2005, 7 x 10, 904 pp. Suggested Price: $209.95 / £134.00

Catalog no. 73745, ISBN: 978-1-4200-7374-4 June 2009, 6-1/8 x 9-1/4, pp. Suggested Price: $159.95 / £97.00

The Unique Properties of H20

Bioceramics and Their Clinical Applications

Edited by

Ruth M. Lynden-Bell, Simon Conway Morris, John D. Barrow, John L. Finney, and Charles Harper

Tadashi Kokubo

In searching beyond our planet, scientists have focused on the idea that evidence of water is evidence of life. However, even if one believes that life is impossible without water, one should consider whether other forms of life may be possible where some variation of water exists. Taking nothing for granted, this volume brings together great thinkers from across disciplines who discuss whether or not the physiochemical properties of water are biocentrically “fine-tuned” for the existence and evolution of life. Exceptionally rigorous in its approach, this book lays a foundation for exploring some of the deepest quandaries in biochemistry.

With contributions from leading international academics, this book reviews the range of bioceramics, their properties, and the spectrum of clinical uses. It begins with a discussion of structure, mechanics, and biological interactions, and then reviews fabrication, microstructure, and properties of specific bioceramics and glasses, concentrating on the most promising materials. The final group of chapters covers the clinical application of bioceramics in joint replacement, bone grafts, tissue engineering and dentistry. Bioceramics and Their Clinical Applications is a useful resource for biomaterials scientists and engineers, as well as for clinicians and the academic community.

Water and Life

Catalog no. K10200, ISBN: 978-1-4398-0356-1 May 2010, 7 x 10, 400 pp. Suggested Price: $89.95 / £57.99

Chubu University, Japan

Catalog no. WP7207, ISBN: 978-1-4200-7207-5 April 2008, 6-1/8 x 9-1/4, 600 pp. Suggested Price: $339.95 / £179.00

Advanced Signal Processing Theory and Implementation for Sonar, Radar, and Non-Invasive Medical Diagnostic Systems, Second Edition Edited by

Bio-Implant Interface

Stergios Stergiopoulos

Improving Biomaterials and Tissue Reactions

University of Western Ontario, Cananda Series: Electrical Engineering & Applied Signal Processing

Jan Eirik Ellingsen and S. Petter Lyngstadaas

Continuing in the bestselling tradition of the first edition, this book integrates topics of signal processing from sonar, radar, and medical system technologies by identifying their concept similarities. The second edition continues to gather the most pertinent information in advanced signal processing and provides substantial updates to the section on non-invasive medical diagnostic system applications, including intracranial ultrasound, an emerging technology that attempts to address non-invasive detection on brain injuries and stroke. The chapter titled Adapting Systems in Signal Processing represents a coherent summary of Simon Haykin’s work in the relevant field.

This volume describes interactions at the interface between biomaterials and living tissue. Much of the focus is on the importance of the implant surface’s topography and chemistry to its interaction with the biological environment. Biomineralization, along with the biological content of the interface and its role in directing cellular response along desired pathways also receive particular attention. The book includes a section that explores the potential of advances on the horizons of current research and more than 175 illustrations, many in color.

Catalog no. 62387, ISBN: 978-1-4200-6238-0 March 2009, 7 x 10, 750 pp. Suggested Price: $159.95 / £97.00

University of Oslo, Norway

Catalog no. 1474, ISBN: 978-0-8493-1474-2 April 2003, 6-1/8 x 9-1/4, 464 pp. Suggested Price: $185.95 / £121.00

Textbook

Advanced Textiles for Wound Care

Biological Performance of Materials

Edited by

Fundamentals of Biocompatibility, Fourth Edition

S. Rajendran

Jonathan Black

University of Bolton, UK

Clemson University (Professor Emeritus), South Carolina, USA

This collection provides a detailed review of how textiles are incorporated into wound care applications, explaining the importance and suitability of using textiles on different wound types. It covers wound management and the importance of laboratory testing in relation to wound care. It comprehensively reviews the different textile dressings available, moist wound management, and bioactive dressings to promote healing. The concluding chapters describe how advanced textiles, such as smart temperature controlled textiles and composites, can be used for wound care products. The final chapter gives an interesting insight into the use of fibrous scaffolds for tissue engineering.

Biological Performance of Materials: Fundamentals of Biocompatibility, Fourth Edition focuses on principles of biological performance at a fundamental level, analyzing interactions between organisms and nonliving materials used in medical devices. The book is divided into three sections which cover the material response to biological systems, host response to biomaterials, and test methods for determining biological response in vitro as well as in animal models and clinical settings. Subsections summarize the physical properties of commonly used metallic, polymeric, and ceramic biomaterials and provide a guide to understanding the clinical performance of implanted biomaterials.

Catalog no. WP9489, ISBN: 978-1-4200-9489-3 June 2009, 6-1/8 x 9-1/4, 384 pp. Suggested Price: $222.95 / £135.00

Catalog no. 3959, ISBN: 978-0-8493-3959-2 December 2005, 6-1/8 x 9-1/4, 520 pp. Suggested Price: $109.95 / £69.99

Biochemistry / Biomaterials & Medical Devices

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

For more information and a complete list Biomaterials Fabrication and Processing Handbook Biologically Inspired Textiles

Edited by

City University of Hongkong

A. Abbott and M. Ellison

Xuanyong Liu

Biomaterials & Medical Devices

Clemson University, South Carolina, USA

Shanghai Institute of Ceramics, China

Written by a distinguished team of international authors, Biologically Inspired Textiles explores the current state of the art in this research arena and examines how biomimetics are increasingly applied to new textile technologies. It discusses the principles, production and properties of biomimetics. Chapters include recombinant DNA technologies and their application for protein production, spinning of fibers from protein solutions and structure/function relationships in spider silk. Building on this foundation, the book then provides a review of the application of biomimetics to a range of textile applications, including the design of clothing and self cleaning textiles.

Comprehensive in scope, this volume focuses on a variety of production and processing aspects of the latest biomaterials. It discusses how scaffolds are used in tissue engineering and describes common implant materials, such as hard tissue, blood contacting, and soft tissue. The book also examines the important role nanotechnology plays in the preparation of drugs, protein delivery, tissue engineering, cardiovascular biomaterials, hard tissue replacements, biosensors, and bio-MEMS. With extensive reference lists in each chapter, this book provides detailed, practical guidance on producing biomaterials and employing them in biomedicine.

Catalog no. WP7985, ISBN: 978-1-4200-7985-2 March 2009, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $219.95 / £115.00

Catalog no. 7973, ISBN: 978-0-8493-7973-4 March 2008, 7 x 10, 720 pp. Suggested Price: $149.95 / £95.00

Biomaterials and Devices for the Circulatory Systems

Textbook

Biomaterials

Edited by

A Nano Approach

T. Gourlay and R. Black

Seeram Ramakrishna, Murugan Ramalingam, T.S. Sampath Kumar, and Winston O. Soboyejo

University of Strathclyde, UK

Heart disease is one of the leading causes of death in the USA and Europe and with increasingly obese populations within the developed world, the trend looks set to continue. This text provides a comprehensive review of biomaterials and devices for use in the circulatory system. Initial chapters discuss fundamental considerations such as tissue response to implanted materials and device biocompatibility, while later chapters cover pertinent technologies such as nanotechnology and biosensor technology. This book is an essential read for those concerned with the repair and regeneration of the circulatory system.

Paul K. Chu

Catalog no. N10153, ISBN: 978-1-4398-2770-3 June 2010, 6 x 9 Suggested Price: $179.95 / £115.00

Using a multi-disciplinary approach, this book examines basic concepts, various processing methodologies, and techniques involved in the preparation and characterization of nanobiomaterials that are specific to biomedical applications. Biomaterials: A Nano Approach spans the historical development of biomaterials to current advances in the field. It describes how basic concepts in nanotechnology are applied to the processing of novel nanobiomaterials, including nanostructured metals and alloys. Presenting illustrative examples and a variety of applications, this text offers a solid framework for understanding present and future trends of biomaterials in human health care systems. Catalog no. 47817, ISBN: 978-1-4200-4781-3 April 2010, 6-1/8 x 9-1/4, 416 pp. Suggested Price: $99.95 / £44.99

Biomaterials Biomaterials and Regenerative Medicine in Ophthalmology

Principles and Applications Edited by

Joon B. Park

Edited by

University of Iowa, Iowa City, USA

T. V. Chirila

Joseph D. Bronzino

Queensland Eye Institute, Australia

Trinity College, Hartford, Connecticut, USA

With an increasingly aged population, eye diseases are becoming more widespread. Biomaterials have contributed in recent years to numerous medical devices for the restoration of eyesight. This book provides readers with a definitive coverage of biomaterials and techniques used for the repair and regeneration of the eye. Initial chapters review applications in the anterior segment of the eye. A second group of chapters discuss applications in the posterior segment of the eye. The final group of chapters in the book covers other pertinent topics such as hydrogel sealants for wound repair in ophthalmic surgery, orbital enucleation implants, and polymeric materials for orbital reconstruction.

Biomaterials: Principles and Applications offers an accessible, comprehensive review of all the major biomaterials in this rapidly growing field. The book provides readers with an understanding of the uses of biomaterials in medicine and dentistry and the rational basis for these applications. It covers biodegradable polymeric materials and their relation to tissue engineering, biologic materials, and biomaterial applications in soft and hard tissues. Concise, topical, yet not overly technical, with nearly 100 figures and tables, no other book covers the entire field of biomaterials so succinctly.

Catalog no. N10052, ISBN: 978-1-4398-0215-1 November 2009, 6 x 9, 560 pp. Suggested Price: $244.99 / £155.00

Catalog no. 1491, ISBN: 978-0-8493-1491-9 August 2002, 7 x 10, 250 pp. Suggested Price: $134.95 / £86.00

Biomaterials for Treating Skin Loss Denis Orgill

Cellular Response to Biomaterials

Brigham and Women’s Hospital, Boston, Massachusetts, USA

Edited by

Carlos Blanco

Lucy Di Silvio

University Hospital Maastricht, The Netherlands

Kings College, London, UK

A comprehensive review of the range of biomaterials for treating skin loss, this book begins with an examination of the basics of skin replacement with chapters on markets and regulation, biomechanics, and the biological environment of skin. It then reviews epidermal and dermal replacement technology with discussions on alternative delivery of keratinocytes, collagen-based and human origin-based dermal replacement, and lyophilized xenogenic products. The book closes with an exploration of combined dermis and epidermal replacement technologies and provides a round-up of skin replacement principles.

Written by world-wide experts under the guidance of a pioneering editor, this volume discusses the response of cells to a wide range of biomaterials targeted at specific medical applications. It first examines cell responses to a variety of polymers and ceramics and discusses degradable polymers and biocompatibility. The next section examines cell responses and regenerative medicine with topics such as vascular grafts, nerve repair, and Bioglass®. Lastly, the text explores the effect of surfaces and proteins on cell response. Specific chapters review nanoengineered surfaces, the influence of plasma proteins on bone cell adhesion, and surface modification of titanium implants.

Catalog no. N10002, ISBN: 978-1-4200-9989-8 February 2009, 6 x 9, 320 pp. Suggested Price: $239.95 / £125.00

Biomedical Composites

Catalog no. WP9373, ISBN: 978-1-4200-9373-5 January 2009, 6-1/8 x 9-1/4, 500 pp. Suggested Price: $289.95 / £153.00

Degradation Rate of Bioresorbable Materials Prediction and Evaluation

Edited by

L. Ambrosio

Fraser Buchanan

University of Naples Federico II, Italy

Queen’s University Belfast, UK

Biocomposites are widely used in the medical industry to repair bone, cartilage, ligaments, and tendons. This book provides a thorough review of the current situation, recent progress, and future trends in composites for biomedical applications. It concentrates on the research and applications of this increasingly popular family of materials. The book begins with an introduction to the material, focusing on the properties, fabrication and design of composites. It then discusses particular applications and biocompatibility of biocomposites. The final group of chapters analyses the mechanical behavior and failure of biocomposites and their future potential.

Bioresorbable materials can be employed to provide significant advances in drug delivery systems and medical implants. The rate of material degradation is critical to performance of both implants and the controlled release of drugs. Degradation Rate of Bioresorbable Materials: Prediction and Evaluation addresses the practicalities of this subject in detail. The first section provides an overview of bioresorbable materials and the biological environment. Degradation mechanisms are reviewed in the second group of chapters in the book, followed by bioresorption test methods in the third part. The fourth section discusses factors influencing bioresorption, and finally, clinical applications are reviewed.

Catalog no. N10042, ISBN: 978-1-4398-0178-9 January 2010, 6 x 9, 648 pp. Suggested Price: $249.95 / £160.00

Catalog no. WP7971, ISBN: 978-1-4200-7971-5 October 2008, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $259.95 / £135.00

Bone Repair Biomaterials

Dental Biomaterials Imaging, Testing and Modelling

Edited by

Joseph A. Planell, Serena M. Best, Damien Lacroix, and Antonio Merolli

Richard Curtis and Timothy Watson

A fundamental aspect of the rapidly expanding medical care sector, bone repair continues to benefit from emerging technological developments. This text provides researchers and students with a comprehensive review of the science and engineering principles behind these developments. The first part reviews the fundamentals of bone repair and regeneration. Further chapters discuss the science and properties of biomaterials used in bone repair, including both metals and biocomposites. Final chapters analyze device considerations such as implant lifetime and failure, and discuss potential applications, as well as the ethical issues that continually confront researchers and clinicians.

A review of the biomaterials used in dentistry, this book explores their performance and how it can be measured and optimized. The text covers optical and electron microscopy imaging techniques for dental biomaterial interfaces, along with specific materials such as dental cements, fiber-reinforced composites, metals, and alloys. It provides an analysis of stress, fracture, wear, and aging in dental biomaterials, and evaluates the performance of dental adhesives and resin-dentin bonds. It also discusses ways of assessing the performance of dental handpieces, crowns, implants, and prostheses, and examines the use of computer models.

Catalog no. N10044, ISBN: 978-1-4398-0195-6 September 2009, 6 x 9, 496 pp. Suggested Price: $229.95 / £145.00

King’s College, London, UK

Catalog no. WP7209, ISBN: 978-1-4200-7209-9 April 2008, 6-1/8 x 9-1/4 Suggested Price: $289.95 / £153.00

Biomaterials & Medical Devices

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

For more information and a complete list Design Controls for the Medical Device Industry Marie B. Teixeira

Joint Replacement Technology

QA/RA Compliance Connection, Inc., Odessa, Florida, USA

Edited by

Richard Bradley

Peter A. Revell

Biomaterials & Medical Devices

Global Consulting Network, Inc., Palm Harbor, Florida, USA

Ashurst and Associates Eastman Dental Institute, UK

Design Controls for the Medical Device Industry provides real-world examples, strategies, and templates for the implementation of effective design control programs that meet ISO 9000 and FDA QSR standards and regulations. It also offers product development models for the production of safe, durable, and cost-efficient medical devices and systems. The book details procedures utilized by leading companies to successfully meet FDA and end-user requirements, manufacture high-quality products, and improve and generate profit. It presents blueprints for the application, evaluation, and refinement of quality assurance and performance practices, from product launch through engineering and assembly.

Increasing numbers of joint revision and replacement operations drive the demand for improved prostheses. This book reviews developments in joint replacement technology, covering the most pertinent materials science and engineering issues as well as specific joints, clinical trial results and sterilization techniques. It discusses biomechanics, tribology, and the chemical environment of the body. The text surveys materials and engineering of joint replacement. It also reviews specific materials, bearing surfaces and bone cements, in addition to the failure of mechanisms and lifetime prediction of joints. The biological environment and interaction of replacement joints are also discussed.

Catalog no. DK5666, ISBN: 978-0-8247-0830-6 September 2002, 6 x 9, 254 pp. Suggested Price: $175.95 / £111.00

Catalog no. WP7962, ISBN: 978-1-4200-7962-3 July 2008, 6-1/8 x 9-1/4, 600 pp. Suggested Price: $299.95 / £163.00

Textbook

Design of Biomedical Devices and Systems Second Edition Vanderbilt University, Nashville, Tennessee, USA

A Laboratory Course in Biomaterials

Richard C. Fries

Wujing Xian

Paul H. King

Textbook

Baxter Healthcare, Round Lake, Illinois, USA

University of Illinois at Urbana-Champaign, USA

The design and functional complexity of medical devices have increased over the past 50 years, evolving from cardiac pacemakers to magnetic resonance imaging. Design of Biomedical Devices and Systems provides a comprehensive overview of this area — including topics related to databases, process analysis, and device improvement — from a strong design perspective. Aimed at senior undergraduates, this text covers all aspects of design that must be considered for complex biomedical projects. This new second edition features additional information on device definition and reliability, as well as testing and hardware verification. All chapters are updated to reflect the latest advances in the field.

A new teaching tool for instructors in biomaterials and bioengineering, this volume is a comprehensive laboratory textbook. It trains students in laboratory skills, data analysis, problem solving, and scientific writing and integrates a variety of principles that include materials science, chemistry, biochemistry, molecular and cell biology, and engineering. Providing detailed descriptions, explanations, and illustrations of experiments, the text also includes a series of questions and answers at the end of each chapter to clarify concepts. Many of the experiments presented are adapted from research papers to reflect the recent progress in biomaterials and bioengineering.

Catalog no. 61798, ISBN: 978-1-4200-6179-6 August 2008, 7 x 10, 424 pp. Suggested Price: $119.95 / £76.99

Catalog no. 75829, ISBN: 978-1-4200-7582-3 June 2009, 7 x 10, 216 pp., Soft Cover Suggested Price: $59.95 / £36.99

Macroporous Polymers Textbook

An Introduction to Biomaterials

Production Properties and Biotechnological/ Biomedical Applications Edited by

Edited by

Bo Mattiasson and Igor Yu Galeaev

Scott A. Guelcher and Jeffrey O. Hollinger

Lund University, Sweden

Carnegie Mellon University, Pittsburgh, Pennsylvania, USA Series: Biomedical Engineering, 12

Ashok Kumar

An Introduction to Biomaterials emphasizes applications of biomaterials for patient care. Written by leading authorities on key biomaterial types, this book underscores the process of biomaterial design, development directed toward clinical application, and testing that leads to therapies for clinical targets. It provides a lucid perspective on the standards available and the logic behind the standards in which biomaterials address clinical needs. This volume offers wellrounded chapters on consensus standards and regulatory approaches to testing paradigms, specific classes of biomaterials, and clinical topics that integrate materials sciences and patient applications.

Macroporous polymers are rapidly becoming the material of choice for many tissue engineering, bioseparation, and bioprocessing applications. Presented in a systematic way, this book addresses the production, characterization, and application of these polymers. The text considers traditional methods of production, including phase separation polymerization, leaching, foaming, and double emulsion, as well as newly merging methods such as cryogelation. The chapters also detail the various applications of macroporous gels for the separation of biomolecules and for the cultivation of mammalian cells in bioreactors, as well as for tissue engineering.

Catalog no. 2282, ISBN: 978-0-8493-2282-2 December 2005, 7 x 10, 576 pp. Suggested Price: $104.95 / £66.99

Catalog no. 84615, ISBN: 978-1-4200-8461-0 December 2009, 6-1/8 x 9-1/4, 534 pp. Suggested Price: $129.95 / £82.00

Indian Institute of Technology, Kampur

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

Ninth Edition

Proceedings of the Fourth International Conference on Healthcare and Medical Textiles

Brian W. Darvell

Edited by

The University of Hong Kong

J.F. Kennedy, S.C. Anand, M. Miraftab, and S. Rajendran

Now in its ninth edition, Materials Science for Dentistry provides a fundamental understanding of the materials on which dentistry depends, covering those aspects of structure and chemistry which govern the behavior and performance of the materials in use. It discusses gypsum, polymers, acrylic, cements, waxes, porcelain and metals. Other chapters review topics such as surfaces, corrosion, mixing, casting, cutting and bonding as well as mechanical testing. The new edition includes a new chapter on further aspects of mechanical testing and new material on condensation silicone and phosphate-bonded investment chemistries, mixing, MTA™ and alternative radiographic imaging techniques.

This work is drawn from the proceedings at the Fourth International Conference on Healthcare and Medical Textiles at the University of Bolton in the United Kingdom. Contributors cover a range of topics, including emerging textile-based biomaterials, hygienic textiles, the use of textiles in infection control and as barrier materials, and bandaging and pressure garments for managing chronic infections such as ulcers. The book also explores the role of textiles in the management of burns and wounds, textile-based implantable devices such as tissue scaffolds and sutures, and intelligent textiles.

Catalog no. N10006, ISBN: 978-1-4398-0105-5 June 2009, 6 x 9, 662 pp., Soft Cover Suggested Price: $69.95 / £46.99

Catalog no. WP7989, ISBN: 978-1-4200-7989-0 November 2008, 6-1/8 x 9-1/4, 512 pp. Suggested Price: $329.95 / £174.00

Nano- and Biocomposites Edited by

The Medical Device R&D Handbook

Alan Kin-tak Lau

Edited by

Oregon State University, Corvallis, USA

Theodore R. Kucklick

Khalid Lafdi

The Hong Kong Polytechnic University, Kowloon

Farzana Hussain

TRKD Medical Devices, Los Gatos, California, USA

University of Dayton, Ohio, USA

The Medical Device R&D Handbook is a practical, hands-on digest of medical device engineering that presents information that is often hard to find or only gained by on-the-job experience. Highlights include rapid-prototyping methods to develop medical devices and instructions on how to choose the best methods for certain applications. It offers special techniques for iterating devices with the best possible results at the lowest cost and includes interviews showcasing innovative principles in application by pioneers in the medical device field. By consulting this volume, engineers can shorten the time it takes to become productive medical device designers.

Advances in nanotechnology are leading to the creation of composites with a myriad of medical applications. This forward-thinking book is one of the first to meld research in biocomposites with advances in nanocomposite technology, to provide an interdisciplinary resource on advanced materials for the biomedical industry. It brings together pioneering researchers who describe their contributions to the field. Among other areas, they cover nanostructured polymer composites and nano/bio composites. They look at developments in tissue engineering, safer resins for tooth and bone repair, and improved artificial joints. They also discuss potential opportunities for continued research.

Catalog no. 2717, ISBN: 978-0-8493-2717-9 November 2005, 6-1/8 x 9-1/4, 376 pp. Suggested Price: $144.95 / £92.00

Catalog no. 8027X, ISBN: 978-1-4200-8027-8 August 2009, 6-1/8 x 9-1/4, 408 pp. Suggested Price: $159.95 / £99.00

Medical Devices and Systems

Natural Fibers, Biopolymers, and Biocomposites

Edited by

Joseph D. Bronzino

Amar K. Mohanty, Manjusri Misra, and Lawrence T. Drzal

Trinity College, Hartford, Connecticut, USA Series: The Biomedical Engineering Handbook, Third Edition

Already referred to as a “bible” of biomedical engineering, the third edition of The Biomedical Engineering Handbook includes so much updated material that it has expanded from two volumes into a three-volume set. From theory to state-ofthe-art applications, the second volume of the set, Medical Devices and Systems reflects trends in both research and practice in all pertinent fields. The book contains sections on medical informatics and bioinformatics and authoritatively covers medical instruments and devices, clinical engineering, medical sensor and imaging technologies, and biomedical signal analysis. For information on the complete Handbook, see page 45 Catalog no. 2122, ISBN: 978-0-8493-2122-1 April 2006, 7 x 10, 1376 pp. Suggested Price: $134.95 / £86.00

Michigan State University, East Lansing, USA

This book discusses the combination of fibers with polymer matrices from both non-renewable and renewable resources. The first source to focus on biobased materials, it explains the rise of petrochemical and plastic products, the problems associated in their disposal, and how biopolymers offer a realistic solution to these problems. The authors discuss recent trends and opportunities for the future use of biocomposites as alternatives to petroleum-based composites, integrating the principles of sustainability, industrial ecology, eco-efficiency, and green chemistry and engineering into developing next-generation materials, products, and processes. Catalog no. 1741, ISBN: 978-0-8493-1741-5 April 2005, 6-1/8 x 9-1/4, 896 pp. Suggested Price: $175.95 / £111.00

Biomaterials & Medical Devices

Materials Science for Dentistry

Medical Textiles 2007

For more information and a complete list Natural-Based Polymers for Biomedical Applications Edited by

Biomaterials & Medical Devices 42

Polyolefin Fibres

Rui L. Reis, Nuno M. Neves, João F. Mano, Manuela E. Gomes, Alexandra P. Marques, and Helena S. Azevedo

Industrial and Medical Applications

Natural origin biopolymers are attractive for use in biomedical applications, partly due to their biocompatibility and degradation characteristics. This book comprehensively reviews this important subject in six in-depth sections. The first section discusses the sources, properties, modification and processing of natural-based polymers, and the second section reviews surface aspects. Parts 3 and 4 cover natural-origin materials for tissue engineering and regenerative medicine, discussing scaffolds, hydrogels and injectable systems. The sustained release of molecules is reviewed in the fifth part of the book, followed by the biocompatibility of natural-based polymers in the final book section.

Polyolefins are among the most widely used commercial polymers. These versatile fibers are durable, chemically resistant, lightweight, economical, and functional. This work provides researchers in materials, as well as product development specialists in industry and biomedical engineering with a comprehensive resource that will assist them with material improvement and product development. The first chapters discuss the structural and chemical properties of different types of polyolefins, as well as production methods. Middle chapters delve into functionality improvement. Closing chapters address how polyolefins can be incorporated into specific industrial, medical, and automotive products.

Catalog no. WP7607, ISBN: 978-1-4200-7607-3 September 2008, 6 x 9, 760 pp. Suggested Price: $319.95 / £175.00

Catalog no. N10000, ISBN: 978-1-4200-9985-0 February 2009, 6 x 9, 320 pp. Suggested Price: $239.95 / £125.00

Orthopaedic Bone Cements

Regenerative Medicine and Biomaterials for the Repair of Connective Tissues

Edited by

Sanjukta Deb

C. Archer and J. Ralphs

Samuel C. O. Ugbolue University of Massachusetts, Dartmouth, USA

King’s College London, UK

Cardiff University, UK

With an increasing number of bone cements available, it is vital that the correct material is selected for specific clinical procedures. A review of the most recent research in this field, this book covers such topics as hip replacements, verteboplasty and wear particles, and osteolysis. It reviews materials and types of cement such as acrylic, polymethylmethacrylate, and calcium phosphate cements and addresses the mechanical properties of bone cements such as fracture toughness and dynamic creep. The book closes with an examination of methods to enhance the properties of bone cements such as antibiotic-loaded bone cements and bioactive cements.

Regenerative medicine for the repair of connective tissues is a fast moving field which generates a lot of interest. The biomaterials and biomechanics for soft tissue repair have been under-represented in the past; particularly the natural association between cartilage, tendons, and ligaments is often not made. This book address this gap by exploring the natural association of cartilage, tendons, and ligaments to provide a review of the different structures, biomechanics and, more importantly, provide a clear discussion of practical techniques and biomaterials which may be used to repair the connective tissues.

Catalog no. WP9302, ISBN: 978-1-4200-9302-5 November 2008, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $279.95 / £156.00

Catalog no. N10011, ISBN: 978-1-4398-0110-9 April 2010, 6 x 9, 600 pp. Suggested Price: $244.95 / £174.00

Second Edition

Reliable Design of Medical Devices

Edited by

Second Edition

Severian Dumitriu

Richard Fries

Polymeric Biomaterials

University of Sherbrooke, Canada

Baxter Healthcare, Round Lake, Illinois, USA

Offering nearly 7000 references, 3900 more than the first edition, Polymeric Biomaterials, Second Edition is a solid source for plastics and biomedical engineers, polymer scientists, biochemists, molecular biologists, macromolecular chemists, pharmacists, cardiovascular and plastic surgeons, and graduate and medical students in these disciplines. Completely revised from the previous edition, it includes coverage of genetic engineering, synthesis of biodegradable polymers, hydrogels, and mucoadhesive polymers, as well as polymers for dermacosmetic treatments, burn and wound dressings, orthopedic surgery, artificial joints, vascular prostheses, and in blood contacting systems.

As medical devices increase in complexity, concerns about efficacy, safety, quality, and longevity increase in stride. The second edition of Reliable Design of Medical Devices presents the basic concepts and the major issues involved in the design of these devices. This edition includes topics such as electronic signature, material selection and biocompatibility, and quick response manufacturing. In addition, it examines Six Sigma philosophy as it pertains to the manufacture of medical devices. The book helps manufacturers implement a reliability assurance program while conforming to current regulations and will also help purchasers formulate effective vendor evaluation methods.

Catalog no. DK1811, ISBN: 978-0-8247-0569-5 November 2001, 287x208, 1168 pp. Suggested Price: $299.95 / £170.00

Catalog no. DK3104, ISBN: 978-0-8247-2375-0 November 2005, 6-1/8 x 9-1/4, 504 pp. Suggested Price: $164.95 / £105.00

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

Edited by

Textbook

Nihon University, Chiyoda-ku, Tokyo, Japan

Applied Biomedical Engineering Mechanics

Shuichi Miyazaki

Dhanjoo N. Ghista

Takayuki Yoneyama University of Tsukuba, Japan

Parkway College, Singapore

Shape memory metals are suitable for a wide range of biomedical devices, including applications in dentistry, bone repair, urology, and cardiology. This volume provides a thorough review of shape memory metals and devices for medical applications. The first part of the book discusses the materials, primarily Ti-Ni based alloys. It covers mechanical properties, thermodynamics, and composition as well as fabrication of parts, chemical reactivity, surface modification, and biocompatibility. The contributors also examine stents, orthodontic devices and endodontic instruments. Finally, future developments in this area are discussed including alternatives to Ti-Ni based shape memory alloys.

Presenting the latest innovations, this text highlights advances in tissue, musculoskeletal, locomotive, orthopedic, occupational, ergonomic, sports, cardiovascular, cardiac, and pulmonary biomechanics. Based on years of teaching experience, the author uses illustrative examples and detailed explanations to show how mechanics disciplines can be applied to a wide range of clinical applications, including the analysis of physiological and organ-system processes, the creation of physiologically compatible organ-assist systems and devices, the performance of pre-surgical analysis in order to develop optimal surgical approaches, and the design of vehicle-occupant systems for occupant comfort.

Catalog no. WP7966, ISBN: 978-1-4200-7966-1 March 2009, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $219.95 / £126.00

Catalog no. DK8315, ISBN: 978-0-8247-5831-8 July 2008, 6-1/8 x 9-1/4, 552 pp. Suggested Price: $139.95 / £89.00

3D Fibrous Assemblies

Biomechanics in Ergonomics

Properties, Applications and Modelling of Three-Dimensional Textile Structures

Second Edition Edited by

Jinlian Hu

Shrawan Kumar

Hong Kong Polytechnic University

University of North Texas, Fort Worth, USA

Written by a distinguished author, this book summarizes key developments and their applications in the textile industry. It begins with an introduction to the concepts and types of 3D fibrous assemblies. It then discusses how 3D fabrics can be applied in textiles products. These range from composites and protective clothing to medical textiles. The remainder of the book reviews the two main 3D fabrics: multi-axial warp knitted fabrics and multi-layer woven fabrics. Exploring themes such as structure, manufacture, properties, and modelling for both fabrics, this volume is a pioneering guide for a broad spectrum of readers.

Three of the most important goals of ergonomics are the comfort, health, and safety of the working population. Written by leaders in the field, this second edition of Biomechanics in Ergonomics presents updated material regarding the biomechanics of tissues and organs in the workplace. This text establishes a foundation for the understanding of gross biomechanical loads on the human system at the tissue level. It describes biomechanical risk factors and supplies exposure assessment tools and techniques. Comprehensive in scope, the book is suitable for use by ergonomic engineers and physical therapists, and as a textbook for ergonomics courses.

Catalog no. WP7986, ISBN: 978-1-4200-7986-9 September 2008, 6-1/8 x 9-1/4, 256 pp. Suggested Price: $219.95 / £115.00

Titanium Alloys Modelling of Microstructure, Properties, and Applications Edited by

Catalog no. 7908, ISBN: 978-0-8493-7908-6 December 2007, 7 x 10, 744 pp. Suggested Price: $99.95 / £63.99

Textbook

Biomechanics of the Upper Limbs

University of Canterbury, New Zealand

Mechanics, Modelling and Musculoskeletal Injuries

Savko Malinov

Andris Freivalds

Wei Sha The Queen’s University of Belfast, UK

Pennsylvania State University, University Park, USA

An exploration of modelling techniques for the microstructure and properties of titanium and its alloys, this book discusses experimental techniques such as microscopy, synchrotron radiation, X-ray diffraction, and differential scanning calorimetry. It reviews physical modelling methods, including thermodynamic modelling, the Johnson-Mehl-Avrami method, finite element modelling, the Phase-field method, and the cellular automata method. It also explores the crystallographic and fracture behavior of titanium aluminide and atomistic simulations of interfaces and dislocations relevant to TiAl. Coverage includes neural network models and surface engineering products.

Combining basic biomechanics with practical bioengineering issues, this book provides more than the general introductions to cumulative trauma disorders and medical management-related books currently on the market. The author covers the musculoskeletal components, their models, and the measurement and prediction of injury potential. The book begins with a basic introduction to biomechanical principles and goes on to cover gross structure of the musculoskeletal system, organization of muscles and muscle anatomy, modelling of muscle mechanics, models of the upper limbs, types of musculoskeletal disorders, and the scientific evidence of risk factors.

Catalog no. N10034, ISBN: 978-1-4398-0148-2 June 2009, 6 x 9, 500 pp. Suggested Price: $255.95 / £155.00

Catalog no. TF2279, ISBN: 978-0-7484-0926-6 June 2004, 6-1/8 x 9-1/4, 624 pp. Suggested Price: $114.95 / £72.99

Biomaterials & Medical Devices / Biomechanics

Shape Memory Alloys for Biomedical Applications

For more information and a complete list Foot and Ankle Motion Analysis Clinical Treatment and Technology Edited by

Gerald F. Harris Marquette University, Milwaukee, Wisconsin, USA

Peter A. Smith Shriners Hospital for Children, Chicago, Illinois, USA

Biomechanics / Biomedical Engineering

Richard M. Marks Medical College of Wisconsin, Milwaukee, USA Series: Biomedical Engineering, 13

Originating as a one-day workshop sponsored by the Shriner’s Hospitals and the National Institutes of Health, this text is a single source reference for the latest assessment technologies and their clinical applications. Presenting basic and advanced clinical applications in pediatric and adult cases, the book also introduces the technological advances themselves from a quantitative perspective. It describes novel approaches and emerging horizons related to mechanical paradigms, imaging, kinetics, robotics and simulation, tri-planar force sensing, and more. The book also includes a chapter of references and sources of support for future research and development prospects. Catalog no. 3971, ISBN: 978-0-8493-3971-4 August 2007, 6-1/8 x 9-1/4, 704 pp. Suggested Price: $185.95 / £121.00

Biofluid Dynamics Principles and Selected Applications Clement Kleinstreuer North Carolina State University, Raleigh, USA

Biofluid Dynamics builds a solid understanding of medical implants and devices from a bioengineering standpoint. The text features extensive worked examples and mathematical appendices, exercises and project assignments to stimulate critical thinking and build problem solving skills, numerous illustrations, including a 16-page full-color insert, computer simulations of biofluid dynamics processes and medical device operation, tools for solving basic biofluid problems, and a glossary of terms. The text can be used as a primary selection for a comprehensive course or two-course sequence or as a reference for professionals in biomedical engineering and medicine. Catalog no. 2221, ISBN: 978-0-8493-2221-1 April 2006, 6-1/8 x 9-1/4, 528 pp. Suggested Price: $104.95 / £66.99

Textbook

Principles of Biomechanics

Biological and Bioenvironmental Heat and Mass Transfer

Ronald Huston

Ashim K. Datta

University of Cincinnati, Ohio, USA Series: Dekker Mechanical Engineering

Textbook

Presenting the fundamental concepts that are required for further research in this field, this volume emphasizes biodynamic modeling and human body models. Beginning with a review of gross human anatomy and a summary of basic terminology, it describes various methods of analysis, including elementary mathematics, elementary mechanics, and the mechanics of materials. Later chapters discuss the modeling of biosystems, tissue biomechanics, biodynamics, kinematics, kinetics, and the inertial properties of human body models. The book concludes with a review of sample applications of biodynamic models in activities such as lifting, maneuvering in space, walking, and swimming. Catalog no. DK494X, ISBN: 978-0-8493-3494-8 December 2008, 6-1/8 x 9-1/4, 442 pp. Suggested Price: $99.95 / £63.99

Basic Introduction to Bioelectromagnetics Second Edition Cynthia Furse, Douglas A. Christensen, and Carl H. Durney

Cornell University, Ithaca, New York, USA

Providing a foundation in heat and mass transport, this book covers engineering principles of heat and mass transfer. The author discusses biological content, context, and parameter regimes and supplies practical applications for biological and biomedical engineering, industrial food processing, environmental control, and waste management. The book contains end-of-chapter problems and sections highlighting key concepts and important terminology, cross-references for easy access to related areas and relevant formulas, detailed examples of transport phenomena, and descriptions of physical processes. It covers mechanisms of diffusion, capillarity, convection, and dispersion. Catalog no. DK1966, ISBN: 978-0-8247-0775-0 March 2002, 8-1/2 x 11, 424 pp. Suggested Price: $93.95 / £59.99

Textbook

Biology for Engineers Arthur T. Johnson

University of Utah, Salt Lake City, USA

University of Maryland, College Park, USA

Completely revised and updated, this new edition facilitates the process of interdisciplinary research by introducing life scientists to the basic concepts of electromagnetic fields. The book outlines elements of EM that are helpful to life scientists working with physicists and electrical engineers. Each concept is presented with an associated application and discussion. Example applications include MRI, NMR, ultrasound, hyperthermia, neural stimulation, and cardiac pacing/defibrillation. With the liberal use of diagrams and graphs, this text covers the entire frequency spectrum through optical frequencies from a qualitative perspective beneficial to life scientists.

Intended as an introductory text on biology from an engineering perspective, this resource elaborates on concepts and technology with an emphasis on the utilization of living things. Rather than treating biology as a science requiring memorization of connections and classifications, the book explores its relevance as an application area for engineering analysis and design. The author takes a broad approach, encompassing everything from genetics and cellular structure to grand ecological systems. Except for a unique chapter on scaling, there are few equations and little quantitative analysis. Because it is an introductory text, ideas and concepts are primary.

Catalog no. 55429, ISBN: 978-1-4200-5542-9 March 2009, 7 x 10, 288 pp. Suggested Price: $99.95 / £60.99

Catalog no. 77635, ISBN: 978-1-4200-7763-6 February 2010, 8-1/2 x 11, 850 pp. Suggested Price: $99.95 / £44.99

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

Edited by

Biomedical Photonics Handbook

Joseph D. Bronzino

Edited by

Trinity College, Hartford, Connecticut, USA Series: The Biomedical Engineering Handbook, Third Edition

Tuan Vo-Dinh

The first of three volumes in The Biomedical Engineering Handbook, Biomedical Engineering Fundamentals builds a strong foundation in the underlying concepts of biomedical engineering. Beginning with an overview of physiology and physiological modeling, simulation, and control, this volume explores bioelectric phenomena, biomaterials, and biomechanics. It also discusses human factors with sections on rehabilitation and human performance engineering. The final section delves into ethical issues. Preeminent experts from around the world share their expertise with many updated chapters representing state-of-the-art technologies and practices, including a section on neuroengineering.

An authoritative source for a broad audience, this handbook integrates interdisciplinary research and development on instrumentation, methods, and clinical applications of interest to scientists, engineers, manufacturers, teachers, students, and clinical providers. Over 150 experts discuss instrumentation, methods, and protocols. The book covers optical techniques for diagnosis, therapy, and prevention of disease; optical detection technologies used in DNA and protein sequencing; and spectroscopic data of biologically and medically relevant species for over 1000 compounds and systems. The book contains introductory material in each chapter and an extensive list of references for further reading.

For information on the complete Handbook, see the following entry. Catalog no. 2121, ISBN: 978-0-8493-2121-4 April 2006, 7 x 10, 1560 pp. Suggested Price: $154.95 / £98.00

Catalog no. 1116, ISBN: 978-0-8493-1116-1 March 2003, 7 x 10, 1872 pp. Suggested Price: $229.95 / £146.00

The Biomedical Engineering Handbook Third Edition - Three-Volume Set

Duke University, Durham, North Carolina, USA

Biomedical Technology and Devices Handbook Edited by

James Moore

Edited by

Texas A&M University, College Station, USA

Joseph D. Bronzino

George Zouridakis

Trinity College, Hartford, Connecticut, USA Series: Electrical Engineering Handbook

University of Houston, Texas, USA Series: Handbook Series for Mechanical Engineering, 12

Already referred to as the “bible” of biomedical engineering, the third edition of The Biomedical Engineering Handbook is even more vast in its scope and depth than the previous two editions. Covering the breadth of the field, this edition includes so much updated material that it has expanded into a three-volume set. Individually, each volume provides a convenient, sharply focused guide to specialized information. Together, these three volumes form the most comprehensive, authoritative, and interdisciplinary reference available, conveniently organized for quick access. This edition includes new sections on neuroengineering, infrared imaging, bioinformatics, molecular biology, and bionanotechnology.

The Biomedical Technology and Devices Handbook illuminates the equipment, devices, and techniques used in modern medicine to diagnose, treat, and monitor human illnesses. With topics ranging from basic procedures like blood pressure measurement to cutting-edge imaging equipment, biological tests, and genetic engineering, the book is organized to navigate smoothly from simple procedures and concepts to more sophisticated and complex ones. Each section contains a description of the technique, its technical considerations, and its use according to its applications and relevant body systems. The book includes protocols, problems, solutions, and references to relevant websites.

For information on individual volumes, see the preceding entry, as well as pages 41 and 60 Catalog no. 2124, ISBN: 978-0-8493-2124-5 April 2006, 7 x 10, 4232 pp. Suggested Price: $229.95 / £146.00

Catalog no. 1140, ISBN: 978-0-8493-1140-6 August 2003, 7 x 10, 840 pp. Suggested Price: $209.95 / £134.00

Textbook

Biomedical Engineering Principles Edited by

Arthur B. Ritter Stevens Institute of Technology, Hoboken, New Jersey, USA

Stanley Reisman New Jersey Institute of Technology, Newark, USA

Biomimetics Biologically Inspired Technologies Yoseph Bar-Cohen

Bozena B. Michniak

Jet Propulsion Laboratory, Pasadena, California, USA

Rutgers University, Pisacataway, New Jersey, USA

Introducing the principles of using biology to inspire designs and biological mechanisms as models for technology, Biomimetics: Biologically Inspired Technologies surveys the field of biomimetics, from modeling to applications. It discusses the biological models useful to engineering, the current state of the field, and the progress and challenges awaiting future researchers. Taking a systems approach to design, it reflects the interdisciplinary nature of the science, integrating materials, structures, actuators, sensors, interfaces, control, adaptability, and intelligence, among others.

Integrating engineering, medicine, biology, and physics, this book clearly defines basic principles in image processing and biomechanics, modeling physiological processes, and bioelectric signal analysis to build a solid understanding of devices and designs for improved functioning of the human body. It includes cutting-edge discussions of tissue engineering, cardiovascular components, bone regrowth, and nerve regeneration. Other topics include technologies at the forefront of cardiac care, such as total artificial hearts, left ventricular assist devices, and stents, as well as issues related to minimally invasive and robotic surgery, next-generation imaging devices, and nanodevices. Catalog no. DK1283, ISBN: 978-0-8247-9616-7 June 2005, 6 x 9, 680 pp. Suggested Price: $104.95 / £66.99

Biomedical Engineering

Biomedical Engineering Fundamentals

Catalog no. 3163, ISBN: 978-0-8493-3163-3 November 2005, 7 x 10, 552 pp. Suggested Price: $164.95 / £105.00

For more information and a complete list Clinical Engineering Edited by

Yadin David, Wolf W. von Maltzahn, Michael R. Neuman, and Joseph D. Bronzino

George Zouridakis University of Houston, Texas, USA

Andrew C. Papanicolaou

Biomedical Engineering

Series: Principles and Applications in Engineering, 13

University of Texas, Houston, USA

Clinical Engineering focuses on managing the deployment of medical technology and integrating it appropriately with desired clinical practices. It provides a description of the wide range of responsibilities clinical engineers encounter, describes technology management and assessment in detail, and reviews the standards and regulatory agencies of interest. The book then details various biomedical sensors, considering both biological and electronic factors in sensor performance. Finally, the book covers bioinstrumentation, addressing traditional topics and recently developed instruments and devices such as pulse oximeters and home-care monitoring devices.

The use of electrophysiological recordings to assess the functional integrity of the nervous system during surgery is gradually becoming part of standard medical practice. This book provides a general but comprehensive introduction to intraoperative monitoring. It includes pictures and drawings that show the exact placement of stimulation and recording electrodes, and contains tables that show exact stimulation and recording parameters and the detailed effects of anesthetic agents on neurophysiological signals. It offers examples of normal recordings and presents discussions of problems that can occur during surgery along with the corresponding abnormal recordings.

Catalog no. 1813, ISBN: 978-0-8493-1813-9 March 2003, 7 x 10, 432 pp. Suggested Price: $134.95 / £86.00

Catalog no. 0886, ISBN: 978-0-8493-0886-4 December 2000, 6-1/8 x 9-1/4, 216 pp. Suggested Price: $114.95 / £72.99

Clinical Procedures for Medical Technology Specialists Laurence J. Street

A Concise Guide to Intraoperative Monitoring

Designing Usability into Medical Products Michael E. Wiklund Wiklund Research & Design, Inc., Concord, Massachusetts, USA

Stephen B. Wilcox

Chilliwack General Hospital, Rosedale, British Columbia, Canada

Design Science, Philadelphia, Pennsylvania, USA

Divided into diagnostic and treatment sections, this book provides a comprehensive overview of the most common medical procedures performed in modern clinical settings. Each section presents common names for the procedure; an outline of the disease or injury for which the procedure is performed; a brief review of the anatomical structures and physiological processes that are involved; staffing, equipment, and pre-procedure requirements; a detailed description of the procedure itself; and a discussion of expected outcomes as well as potential complications. Each chapter includes a summary and study questions, and the appendices offer a glossary and a table of normal values.

Advocating a user-centered approach to medical technology design, this book covers the essential processes and specific techniques necessary to produce safe, effective, usable, and appealing medical systems and products. Written by experts on user-centered research, design, and evaluation, the book provides a range of alternative approaches. Wiklund and Wilcox explore how to make medical devices safe and effective by involving users in the design process. They discuss specific design and evaluation methods and tools, present case studies of userfriendly medical technologies and corporate human factors programs, and supply related resources for medical design professionals.

Catalog no. 81993, ISBN: 978-1-4200-8199-2 May 2010, 7 x 10, 600 pp. Suggested Price: $139.95 / £89.00

Catalog no. 2843, ISBN: 978-0-8493-2843-5 February 2005, 6-1/8 x 9-1/4, 376 pp. Suggested Price: $124.95 / £79.99

Combination Products Regulatory Challenges and Successful Product Development Smita Gopalaswamy

Ergonomics for Rehabilitation Professionals

Advanced Solutions Consultants, Inc., Parkland, Florida, USA

Edited by

Venky Gopalaswamy

Shrawan Kumar

Johnson and Johnson, New Brunswick, New Jersey, USA

University of North Texas, Fort Worth, USA

The market for combination products is continually expanding, and consequently, their manufacture continues to raise challenges. This text provides an overview of the process from start to finish, complete with relevant definitions, and then shows how to establish a design and development plan. It provides an overview of FDA and other regulatory expectations and covers resource requirements, manufacturing, pitfalls, post-launch compliance requirements, and agency audits and challenges. The book presents practical guidelines on how to develop combination products successfully and how to implement them into the market successfully and in a timely manner.

Designed to meet the diverse needs of therapists, this book presents a new approach to rehabilitation that integrates ergonomics concepts to address the wide range of problems commonly encountered by professionals. The first section addresses general concepts such as anthropometry and tissue mechanics. The next part explores whole body biomechanics, demonstrating the ergonomic effects of physiological and biomechanical factors. The third section focuses on regional biomechanics, explaining the rationale for ergonomic intervention. Finally, the book offers a detailed discussion of the ergonomic paradigm in rehabilitation, including the use of physical demands analysis.

Catalog no. 64460, ISBN: 978-1-4200-6446-9 April 2008, 6-1/8 x 9-1/4, 264 pp. Suggested Price: $139.95 / £89.00

Catalog no. 8146, ISBN: 978-0-8493-8146-1 April 2009, 6-1/8 x 9-1/4, 640 pp. Suggested Price: $99.95 / £60.99

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Handbook of Anatomical Models for Radiation Dosimetry Xie George Xu Rensselaer Polytechnic Institute, Troy, New York, USA

Keith F. Eckerman Oak Ridge National Laboratory, Tennessee, USA Series: Series in Medical Physics and Biomedical Engineering, 14

Textbook

Introduction to Physics in Modern Medicine Suzanne Amador Kane Haverford College, Pennsylvania, USA

Spanning the 40-year history of human model development, this volume presents all of the major anatomical and physical models that have been developed for human body radiation protection, diagnostic imaging, and nuclear medicine therapy. This comprehensive reference explores how these models have evolved over time and the role that modern technologies have played in this development. In addition, it evaluates the specific strengths of each model, discusses the wide range of applications available for these models, and addresses technical aspects of human modeling and computer simulations. Data sets are available for download on an accompanying website.

The medical applications of physics are not typically covered in introductory physics courses. Introduction to Physics in Modern Medicine fills that gap by explaining the physical principles behind technologies such as surgical lasers and computed tomography (CT or CAT) scanners. Each chapter includes a short explanation of the scientific background, making this book highly accessible to those without an advanced knowledge of physics. This book is intended for medicine and health studies students who need an elementary background in physics, but it also serves well as a non-mathematical introduction to applied physics for undergraduate students in physics, engineering, and other disciplines.

Catalog no. C5979, ISBN: 978-1-4200-5979-3 September 2009, 7 x 10, 757 pp. Suggested Price: $129.95 / £78.99

Catalog no. TF1623, ISBN: 978-0-415-30171-8 November 2002, 7 x 10, 344 pp., Soft Cover Suggested Price: $67.95 / £42.99

Intelligent and Adaptive Systems in Medicine Edited by

Medical Nanotechnology and Nanomedicine

Olivier C. L. Haas and Keith J. Burnham

Harry F. Tibbals

Coventry University, UK Series in Medical Physics and Biomedical Engineering

University of Texas Southwestern Medical Center, Dallas, USA Perspectives in Nanotechnology Series

This book clearly and concisely explains a range of adaptive and intelligent systems, highlighting their benefits and limitations with realistic medical examples. It illustrates how these systems can be used in all stages of medical treatment. Each chapter examines an intelligent and adaptive system, explains the techniques and algorithms behind the systems, and explores how to solve medical and biomedical problems using the system. The book focuses on the tools of fuzzy logic, artificial neural networks, neuro-fuzzy modeling, adaptive and predictive control, systems and statistical modeling, and image processing.

A highly accessible overview of alternative and conflicting concepts in the rapidly developing nanotechnology revolution, this volume reviews current research and development in nanoscience and illustrates the accomplishments and possibilities for application in nanomedicine. Providing an introduction, it offers clarity and understanding to the medical professional as well as those without medical background. Divided into three parts, the first presents a historical background, including definitions and recent trends. The second investigates the current status of the field and its application to medicine and the biomedical sciences. The third looks at future directions and possibilities.

Catalog no. IP385, ISBN: 978-0-7503-0994-3 March 2008, 6-1/8 x 9-1/4, 400 pp. Suggested Price: $149.95 / £95.00

Textbook

Introduction to Molecular Biology, Genomics and Proteomics for Biomedical Engineers Robert B. Northrop and Anne N. Connor University of Connecticut, Storrs, USA Series: Biomedical Engineering, 14

Catalog no. K10431, ISBN: 978-1-4398-0874-0 May 2010, 6-1/8 x 9-1/4, 275 pp., Soft Cover Suggested Price: $49.95 / £31.99

Textbook

Medical Physics and Biomedical Engineering B.H. Brown, R.H. Smallwood, D.C. Barber, P.V. Lawford, and D.R. Hose Series in Medical Physics and Biomedical Engineering

An introductory text, this book has been written for engineers and scientists who have not studied molecular biology, genomics, and proteomics, and who are working with, or planning to work with, living systems. The authors assume readers are familiar with basic calculus, physics, and linear algebra. They describe the very complex biochemical relations that permit life to exist, highlighting the specialized organic molecules in living organisms, and describes how they interact and react. This is a primer, not intended as an academic short-cut or a replacement for formal, in-depth course work, but intended to broaden the background and pique the interest of undergraduate students.

Appropriate for senior undergraduates and graduates, this text presents the underlying physics, electronics, anatomy, and physiology and addresses practical applications of biomedical engineering. The structured approach of the text builds and broadens the material of opening chapters in the later chapters. The book covers biomechanics, image formation techniques, biomedical devices, physiological signals and responses, and respiratory and cardiovascular function and measurement. It includes chapter problems with short questions to test understanding of the main principles and longer questions to test more in-depth knowledge, along with detailed bibliographies with references to introductory texts and research materials.

Catalog no. 61194, ISBN: 978-1-4200-6119-2 October 2008, 7 x 10, 480 pp. Suggested Price: $99.95 / £44.99

Catalog no. IP447, ISBN: 978-0-7503-0368-2 January 1998, 7 x 10, 768 pp., Soft Cover Suggested Price: $93.95 / £48.99

Biomedical Engineering

Edited by

For more information and a complete list Mobile Telemedicine A Computing and Networking Perspective Edited by

Yang Xiao The University of Alabama, Tuscaloosa, USA

From Disability to Possibility

Hui Chen

Tom Chau

Biomedical Engineering

Virginia State University, Petersburg, USA

Bloorview Kids Rehab, Toronto, California, USA

Advances in the area of wireless and mobile telemedicine to diagnose and treat patients are drawing increased attention from healthcare providers and recipients, industry, researchers, and government. This volume examines computing and network dilemmas that arise from wireless and mobile telemedicine. With contributions from many prominent international researchers, the book gives an overview of patient care and monitoring, discusses the use of telemedicine in cardiology and diabetes, analyzes security and privacy considerations, examines issues relating to networking support, and concludes with a section on the opportunities and challenges that are faced by those involved in this exciting technology.

This volume provides an up-to-date synopsis of advances in pediatric rehabilitation engineering research. Offering a single comprehensive resource on the latest research findings, each chapter presents a different area of technology or explores a development of particular clinical relevance to pediatric rehabilitation. The material within each chapter also includes a conceptual description of the technology and underlying scientific principles, followed by a synthesis of relevant literature, recent advances, selected clinical case studies (where applicable), and opportunities for future directions.

Catalog no. AU6046, ISBN: 978-1-4200-6046-1 June 2008, 6-1/8 x 9-1/4, 440 pp. Suggested Price: $79.95 / £49.99

Monitoring of Respiration and Circulation J. A. Blom Eindhoven University of Technology, The Netherlands

Pediatric Rehabilitation Engineering

There are books covering medical instrumentation, modeling, physiological models, and signal processing, but this is the first to offer a broad integration of all these subjects. Monitoring of Respiration and Circulation provides a survey of the field, a review of the necessary fundamentals on which deeper study can be based, and an overview of possible search terms. The early chapters refresh and deepen knowledge and introduce modeling. The middle chapters describe important clinical measurement methods and the information they provide about a patient, including approaches, possibilities, limitations and accuracies. Finally, the book discusses clinical therapeutic instruments. Catalog no. 2083, ISBN: 978-0-8493-2083-5 December 2003, 6-1/8 x 9-1/4, 200 pp. Suggested Price: $104.95 / £66.99

Optimization in Medicine and Biology

Catalog no. K10416, ISBN: 978-1-4398-0842-9 June 2010, 6-1/8 x 9-1/4, 400 pp. Suggested Price: $119.95 / £76.99

Semiconductor Radiation Detection Systems Edited by

Krzysztof Iniewski CMOS Emerging Technologies Inc., Vancouver, British Columbia Series: Devices, Circuits, and Systems, 2

An essential resource for anyone involved with the use of detectors and electronics in healthcare, this book addresses state-of-the-art semiconductor detector and integrated circuit design in the context of medical imaging using ionizing radiation. It includes new, exciting opportunities in x-ray detection, computer tomography (CT), bone dosimetry and nuclear medicine (PET, SPECT). In addition to medical imaging, the book explores other applications of semiconductor radiation detection systems in security applications such as luggage scanning, dirty bomb detection, and border control. Catalog no. K10214, ISBN: 978-1-4398-0385-1 March 2010, 6-1/8 x 9-1/4, 464 pp. Suggested Price: $149.95 / £95.00

Tunable Laser Applications

Edited by

Second Edition

Gino J. Lim

Edited by

University of Houston, Texas, USA

F. J. Duarte

Eva K. Lee

Interferometric Optics, Rochester, New York, USA Series: Optical Science and Engineering

Georgia Institute of Technology, Atlanta, USA

Integrating foundational theory, modeling techniques, algorithms, and applications, this comprehensive reference highlights recent advances in optimization techniques for solving complex problems in medical and biological research. It discusses mathematical programming techniques for medical decision-making processes and applies them to pediatric vaccine formularies, cancer treatment planning models, and the cost-effectiveness of HIV programs. It also examines optimization in biology and discusses algorithms for genomic analysis; probe design and selection; and algorithms and software packages to aid in probe selection and design. The appendix provides a short tutorial on Integer Programming (IP). Catalog no. AU0563, ISBN: 978-0-8493-0563-4 January 2008, 6-1/8 x 9-1/4, 592 pp. Suggested Price: $149.95 / £95.00

With an emphasis on biological and medical applications, the second edition of Tunable Laser Applications reflects the significant developments in tunable lasers and tunable laser applications that have taken place over the past decade. Written by leading international experts, this edition covers various types of tunable laser sources, including tunable semiconductor lasers, solid-state dye lasers, fiber lasers, table-top lasers, free-electron lasers, and interferometric imaging-based lasers. It also provides a practical overview of a wide range of scientific applications for the biological and medical fields, including MEMS and x-ray imaging. Catalog no. 60279, ISBN: 978-1-4200-6009-6 August 2008, 6-1/8 x 9-1/4, 480 pp. Suggested Price: $149.95 / £95.00

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Data, Equations and Their Practical Uses

Biomedical Imaging in Experimental Neuroscience Edited by

Edited by

Nick Van Bruggen

Dale Ensminger

Genentech Incorporated, San Francisco, California, USA

Sunnyvale, California, USA

Timothy Roberts

Foster B. Stulen Ethicon Endo-Surgery, Cincinnati, Ohio, USA

University of Toronto, Ontario, Canada Series: Frontiers in Neuroscience, 18

Ultrasonics is a form of acoustical energy with practical applications in a variety of areas, including medicine and nondestructive testing. This volume provides data and functions gathered from several areas of science and technology. To facilitate the use of ultrasonic energy, this book evaluates the practicality of new ideas and explores how to make important data available for the design of ultrasonic systems to meet present and new developments, such as applications in standard and harsh environments. Additional coverage includes design equations, piezoelectric materials, magnetostrictive transducer design data, materials evaluation, and mechanical effects of ultrasonic energy.

With the emergence of genetically manipulated laboratory mice as one of the most powerful tools for neuroscientists, imaging techniques capable of providing anatomical and functional information of small animals have become extremely important. Emphasizing data analysis and interpretation, Biomedical Imaging in Experimental Neuroscience presents a comprehensive review of the noninvasive biomedical imaging techniques available for laboratory animal research. It covers the scope and limitations of these methods and analyzes their impact on in vivo neuroscience research. The book also provides a concise theoretical review of the pertinent physics.

Catalog no. DK8307, ISBN: 978-0-8247-5830-1 December 2008, 6-1/8 x 9-1/4, 508 pp. Suggested Price: $139.95 / £89.00

Catalog no. 0335, ISBN: 978-0-8493-0122-3 December 2002, 6-1/8 x 9-1/4, 368 pp. Suggested Price: $159.95 / £99.00

Textbook

Automated Image Detection of Retinal Pathology Herbert F. Jelinek

Biosignal and Medical Image Processing Second Edition

Medical University of Vienna, Austria

John L. Semmlow

Michael J. Cree University of Waikato, Hamilton, New Zealand

Rutgers University, Piscataway, New Jersey, USA Series: Signal Processing and Communications, 22

Providing background on the impact of eye disease on the community, Automated Image Detection of Retinal Pathology discusses the effect of automated assessment programs on health care provision. This book offers examples and analyzes the use of automated computer techniques, such as pattern recognition, in detecting retinal images as well as diabetic retinopathy. Addressing the benefits and challenges of automated health care in the field of ophthalmology, it details the increasing practice of telemedicine screening along with other advanced applications including arteriolar-venous ration, which has been shown to be an early indicator of cardiovascular, diabetes, and cerebrovascular risk.

This second edition of a popular volume provides a complete set of signal processing tools including diagnostic decision-making tools and classification methods. New chapters cover adaptive neural nets, linear discriminators, and support vector machines. Examples and problems in MATLAB® encourage exploration of important properties of signal and image processing tools. An accompanying CD-ROM features data, support subroutines, and source code from examples in the text. An educational support CD-ROM that contains a solutions manual, a suggested syllabus, and PowerPoint® presentations of all chapters is also available for qualified instructors.

Catalog no. 7556, ISBN: 978-0-8493-7556-9 October 2009, 6 x 9, 384 pp. Suggested Price: $139.95 / £89.00

Catalog no. 62301, ISBN: 978-1-4200-6230-4 October 2008, 7 x 10, 472 pp. Suggested Price: $99.95 / £39.99

Computational Intelligence in Medical Imaging Techniques and Applications Edited by

Biomedical Image Analysis Rangaraj M. Rangayyan University of Calgary, Alberta, Canada Series: Biomedical Engineering, 11

Biomedical Image Analysis demonstrates the benefits reaped from the application of digital image processing, computer vision, and pattern analysis techniques to biomedical images, including improving diagnostic confidence through quantitative analysis. The book focuses on post-acquisition challenges such as image enhancement, detection of edges and objects, analysis of shape, quantification of texture and sharpness, and pattern analysis, rather than on the imaging equipment and imaging techniques. Each chapter addresses several problems associated with imaging or image analysis, outlining the typical processes and then detailing more sophisticated methods directed to the specific problems of interest. Catalog no. 9695, ISBN: 978-0-8493-9695-3 December 2004, 6-1/8 x 9-1/4, 1312 pp. Suggested Price: $104.95 / £66.99

Gerald Schaefer Aston University, Birmingham, UK

Aboul Ella Hassanien Kuwait University, Safat

Jianmin Jiang University of Bradford, West Yorkshire, UK

A compilation of the latest trends in the field, this book explores how intelligent computing can bring enormous benefit to existing technology in medical image processing and also how it can improve medical imaging research. It covers stateof-the-art research toward integrating medical image processing with artificial intelligence and machine learning approaches. The book presents a range of computational algorithms and techniques, such as neural networks, fuzzy sets, evolutionary optimization, and Monte Carlo simulations. It encompasses many important applications, including the identification of melanoma and prostate cancer analysis. Catalog no. C6059, ISBN: 978-1-4200-6059-1 March 2009, 6-1/8 x 9-1/4, 504 pp. Suggested Price: $99.95 / £60.99

Biomedical Engineering / Biomedical Imaging

Ultrasonics

For more information and a complete list Textbook Includes a CD-ROM

Computer Vision From Surface to Objects

An Interactive Learning Approach

Edited by

Elizabeth Berry

Christopher W. Tyler

Elizabeth Berry Ltd, Leeds, UK

Biomedical Imaging

Smith-Kettlewell Eye Research Institute, San Francisco, California, USA

Andrew J. Bulpitt

Taking an integrated approach to the mathematical, computational, and neuroscientific strategies to analyze 3D structures in a visual scene, this groundbreaking work presents the long-awaited breakthrough to the third dimension of conceptualization. The book covers the advanced object representation requirement of surface structure interpolation across a sparse array of cues to the available depth or distance data. It addresses issues in surface representation and layout, such as surface invariants, shape constancy, and Bayesian shape priors, as well as partial object overlap and background occlusion, which is considered a crucial component for neural representation in the human brain.

Series in Medical Physics and Biomedical Engineering

Catalog no. K10887, ISBN: 978-1-4398-1712-4 April 2010, 6-1/8 x 9-1/4, 200 pp. Suggested Price: $89.95 / £57.99

University of Leeds, School of Computing, UK

Covering all the basics, this self-contained introduction explores the physical principles that underpin the technique of MRI. It links key principles to the main components of an MR system, such as radio frequency coils and gradient coils, and outlines the steps of spatial localization: slice selection, frequency encoding, and phase encoding. The text also illustrates how an image is generated. The authors integrate exercises and detailed solutions within the text, include 150 multiplechoice questions with answers in the back of the book, and provide a CD-ROM with worked examples, animations, exercises, and interactive programs. Catalog no. C9012, ISBN: 978-1-58488-901-4 December 2008, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $59.95 / £33.99

Textbook

Image Processing with MATLAB® Diagnostic Endoscopy Edited by

Haishan Zeng BC Cancer Research Centre, Vancouver, British Columbia, Canada Series: Series in Medical Physics and Biomedical Engineering

Combining a professional development course on diagnostic endoscopy and the authors’ graduate course on biomedical optics, this work is written for researchers in medical optics and biomedical engineering as well as graduate medical optics students. It uses extensive examples and case studies to familiarize readers with the basics of endoscopic optics, the pros and cons of white light endoscopy and fluorescence endoscopy for diagnostic applications, and various microscopic endoscopy imaging modalities. It covers basic optics, details of design, and biomedical uses, as well as microscopic endoscopy and endoscopic spectroscopy.

Fundamentals of MRI

Catalog no. C8346, ISBN: 978-1-4200-8346-0 June 2010, 6-1/8 x 9-1/4, 288 pp. Suggested Price: $99.95 / £63.99

Diagnostic Ultrasound Imaging and Blood Flow Measurements K. Kirk Shung University of Southern California, Los Angeles, USA

Keeping mathematical derivations to a minimum, Diagnostic Ultrasound: Imaging and Blood Flow Measurements begins with an overview of the field, the strengths and weaknesses of the technology, and its role relative to other imaging modalities. The focus then moves to the fundamental physics involved, a detailed discussion of the transducer, conventional imaging approaches, and Doppler measurements. The next chapters explore new developments such as flow, displacement, contrast, harmonic, intracavity, and 4-D imaging. The author concludes by reviewing the current status and standards on bioeffects along with a unique chapter on measuring ultrasonic properties of tissues. Catalog no. DK1305, ISBN: 978-0-8247-4096-2 September 2005, 6-1/8 x 9-1/4, 232 pp. Suggested Price: $124.95 / £79.99

Applications in Medicine and Biology Omer Demirkaya King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

Musa Hakan Asyali Erciyes University, Kayseri, Turkey

Prasanna K. Sahoo University of Louisville, Kentucky, USA

This text explains complex, theory-laden topics in image processing through examples and MATLAB® algorithms. It provides these algorithms to help scientists and researchers quickly identify the most effective solution method for a particular problem at hand. The authors emphasize three-dimensional processing and analysis as well as statistical and stochastic modeling. They cover the new areas of nonlinear diffusion filtering and PDE-based image filtering, address relatively advanced topics, such as Markov random field-based image segmentation, and highlight applications with images from medicine and biology. They also include real-world examples and exercises in every chapter. Catalog no. 9246, ISBN: 978-0-8493-9246-7 December 2008, 6-1/8 x 9-1/4, 451 pp. Suggested Price: $99.95 / £42.99

Medical Image Analysis Methods Edited by

Lena Costaridou University of Patras, Greece Electrical Engineering & Applied Signal Processing Series, 18

Medical Image Analysis Methods details the primary methods, techniques, and approaches used to improve the quality of visually perceived images as well as quantitative detection and diagnostic decision aids. This comprehensive volume illustrates analytical techniques such as computer-aided diagnosis (CAD), adaptive wavelet image enhancement, and data-driven optimized image segmentation and registration. Paradigms of the analysis methods used in bioinformatics and neurosciences are also provided in respective chapters. In addition, this reference reviews techniques that are used to evaluate these major medical-image processing and analysis methods. Catalog no. 2089, ISBN: 978-0-8493-2089-7 July 2005, 6-1/8 x 9-1/4, 504 pp. Suggested Price: $175.95 / £111.00

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

Concepts and Methods

Photoacoustic Imaging and Spectroscopy Edited by

Jiri Jan

Lihong Wang

Brno University of Technology, Czech Republic Series: Signal Processing and Communications, 25

Washington University, St. Louis, Missouri, USA Series: Optical Science and Engineering, 144

Development of medical image processing methods and the interpretation of complicated or unexpected results require deep understanding of the underlying theory and methods involved in image processing and analysis. This text provides a firm grounding in the principles and insight into the methods of treating the image material. It demonstrates consistent reasoning based on a firm grasp of image processing fundamentals, favoring continuous understandable explanation over strict mathematical formalism. The author first considers images as multidimensional signals, then as data sources, and finally delves into individual image processing topics such as tomographic image reconstruction and image fusion.

Photoacoustic imaging combines electromagnetic and ultrasonic waves to provide deep speckle-free imaging with high electromagnetic contrast at a high resolution. By means of spectroscopy, photoacoustics can also provide functional sensing of physiological parameters such as the oxygen saturation of hemoglobin. The book presents the state of the art in this exciting new area of research, offering complete coverage of photoacoustic, optoacoustic, and thermoacoustic imaging. Featuring 200 illustrations, this volume shows the superiority of photoacoustic images over x-ray and ultrasonic images. It also discusses all potential applications of photoacoustic technology, including biomedical applications.

Catalog no. DK1212, ISBN: 978-0-8247-5849-3 November 2005, 6 x 9, 760 pp. Suggested Price: $164.95 / £105.00

Medical Image Registration Edited by

Catalog no. 59912, ISBN: 978-1-4200-5991-5 March 2009, 8-1/2 x 11, 518 pp. Suggested Price: $149.95 / £89.00

Textbook Includes a CD-ROM

Hammersmith Hospital, London, UK

A Practical Approach to Medical Image Processing

Derek L.G. Hill and David J. Hawkes

Elizabeth Berry

Guy’s Hospital, London, UK Series: Biomedical Engineering, 5

Elizabeth Berry Ltd, Leeds, UK Series in Medical Physics and Biomedical Engineering

This reference details the theory, technology, and practical implementations of image registration in a variety of medical settings. International experts thoroughly explain why image registration is important, describe its applications in a nonmathematical way, and include rigorous analysis for those who plan to implement algorithms themselves. It is accessible and informative to those new to the field, yet it provides in-depth treatment for the expert. With its practical examples, extensive illustrations, and comprehensible approach, Medical Image Registration is a must-have guide for medical physicists, clinicians, and researchers.

Using an interactive workbook approach to introduce the concept in a nonmathematical way, A Practical Approach to Medical Image Processing explains the techniques through worked examples, exercises, and problems and validates each technique with a corresponding case study, which originates from a published journal article. The examples and exercises are supplied on an accompanying CD-ROM that uses well-known, readily available software such as the software package ImageJ. With an emphasis on the effects of a technique on an image, this text provides a thorough understanding of medical image processing that allows readers to make a reasoned choice of method.

Catalog no. 0064, ISBN: 978-0-8493-0064-6 June 2001, 6-1/8 x 9-1/4, 392 pp. Suggested Price: $124.95 / £79.99

Catalog no. C8245, ISBN: 978-1-58488-824-6 December 2007, 6-1/8 x 9-1/4, 304 pp. Suggested Price: $83.95 / £39.99

Joseph V. Hajnal

Textbook

MicroComputed Tomography

The Science of Imaging

Methodology and Applications

An Introduction, Second Edition

Stuart R. Stock

Graham Saxby

Northwestern University, Evanston, Illinois, USA

University of Wolverhampton (Retired), UK

Due to the availability of commercial laboratory systems and the emergence of user facilities at synchrotron radiation sources, studies of microcomputed tomography (or microtomography) have increased exponentially. MicroComputed Tomography provides a complete introduction to microCT, describing how to use this technique effectively and how to understand its results. The first part of the book focuses on methodology, covering experimental methods, data analysis, and visualization approaches, while the second part of the book addresses various microCT applications, including porous solids, microstructural evolution, soft tissue studies, multimode studies, and indirect analyses.

A fundamental introduction to the subject, this volume takes readers on a grand tour of imaging. Starting with the fundamentals of light and basic cameras, the authors journey through television and holography to advanced scientific and medical imaging. Topics such as digital recording of images, the photographic process, and film development are dealt with in an informative and entertaining manner. The book keeps mathematics to a minimum and is copiously supplemented with examples. According to the RPS Journal, this is “…a truly valuable book, magnificently bringing together such diverse technologies.”

Catalog no. 58762, ISBN: 978-1-4200-5876-5 December 2008, 6-1/8 x 9-1/4, 336 pp. Suggested Price: $129.95 / £82.00

Catalog no. K10653, ISBN: 978-1-4398-1286-0 April 2010, 8-1/2 x 11, 290 pp. Suggested Price: $69.95 / £36.99

Biomedical Imaging

Medical Image Processing, Reconstruction and Restoration

For more information and a complete list Shape Classification and Analysis Theory and Practice, Second Edition Cybernetic Vision Research, San Carlos, Brazil

Coarse-Graining of Condensed Phase and Biomolecular Systems

Roberto Marcondes Cesar, Jr.

Edited by

University of Sao Paulo, Brazil Image Processing Series, 10

Gregory A. Voth

Shape analysis offers great potential for applications in diverse areas, from materials science to biology and neuroscience. Including numerical tools for characterization, this new edition presents the most advanced imaging techniques for the analysis of general biological shapes, such as cells, tissues, organs, and organisms. Various chapters review the main approaches for shape classification. Although focused on two-dimensional shapes, which are more effectively handled by current technology, the text also covers basic concepts and techniques for threedimensional shapes. These methods offer a rich resource for the computational characterization and classification of biological shapes.

Assembling some of the most influential, world-renowned researchers in the field, this book covers the latest developments in the coarse-grained molecular dynamics simulation and modeling of condensed phase and biomolecular systems. Each chapter focuses on specific examples of evolving coarse-graining methodologies and presents results for a variety of complex systems. The contributors discuss the minimalist, inversion, and multiscale approaches to coarse-graining and explore its emerging challenges. They also connect atomic-level information with new coarse-grained representations of complex systems, such as lipid bilayers, proteins, peptides, and DNA.

Catalog no. 7929, ISBN: 978-0-8493-7929-1 April 2009, 6-1/8 x 9-1/4, 685 pp. Suggested Price: $129.95 / £78.99

Catalog no. 59556, ISBN: 978-1-4200-5955-7 September 2008, 7 x 10, 456 pp. Suggested Price: $159.95 / £99.00

Signal Processing in Magnetic Resonance Spectroscopy with Biomedical Applications

Handbook of Physics in Medicine and Biology

Dzevad Belkic and Karen Belkic

Robert Splinter

Karolinska Institute, Stockholm, Sweden

University of North Carolina at Charlotte, USA

Addressing the critical need in clinical oncology for robust and stable signal processing in MRS, this book explores cutting-edge theory-based innovations for obtaining reliable quantitative information from MR signals for cancer diagnostics. By defining the natural framework of signal processing using the well-established theory of quantum physics, it illustrates how advances in signal processing can optimize MRS. Applying the fast Padé transform (FPT) to several problems in oncology diagnostics, including ovarian, breast, and prostate cancer, the book examines the remarkable ability of the FPT to unambiguously quantify isolated, tightly overlapped, and nearly confluent resonances.

This handbook presents a quantitative physical description of all aspects of cellular and organ performance and methods used to measure these functions. Moreover, it covers the physics necessary to understand the theoretical and practical basis for development of diagnostic and therapeutic tools. It offers readers a foundation in relevant physical principles and technology critical to understanding biological functioning for application to biomedical research and healthcare. Throughout the book, expert contributors emphasize aspects of diagnostic and therapeutic modalities in relation to normal physiological functions.

Luciano da Fontoura Costa

Biomedical Imaging / Biophysics 52

Catalog no. K10321, ISBN: 978-1-4398-0644-9 December 2009, 6-1/8 x 9-1/4, 436 pp. Suggested Price: $119.95 / £76.99

University of Utah, Salt Lake City, USA

Catalog no. 75241, ISBN: 978-1-4200-7524-3 March 2010, 8-1/2 x 11, 680 pp. Suggested Price: $149.95 / £95.00

Optical Tweezers Methods and Applications Edited by

Chiral Recognition in the Gas Phase Edited by

Anne Zehnacker

Miles J. Padgett University of Glasgow, Scotland

Justin Molloy MRC Institute for Medical Research, London, UK

David McGloin

CNRS, Laboratoire de Photophysique Moleculaire, Orsay, France

University of Dundee, Scotland Series in Optics and Optoelectronics, 7

An exploration of the fundamental aspects of chiral recognition at the molecular level, this book describes the forces at play in this process. Providing a unified view of recent research results, the book includes topics that have direct relevance to the rational design of chiral separation media and the understanding of fundamental reactions between molecules. The text summarizes, expands, and connects new data so that it can be appreciated and used by a more general scientific audience. Edited by an expert in the field with contributors of equal caliber, the book is quite possibly the first comprehensive review of state-of-the-art work that has occurred during the past 10 years.

Bringing together many landmark papers on the field, this compendium covers the techniques and applications of optical tweezers. It covers Arthur Ashkin’s initial work on radiation pressure and the immediate progress following his seminal demonstration. The expert contributors explore recent biological, colloidal, and microfluidic applications. They also analyze the mechanisms underpinning basic tweezer force and the interaction among many particles held within multiple tweezer systems. In addition, they explain the conversion of optical tweezers into optical spanners as well as the creation of holographic tweezers using spatial light modulators.

Catalog no. 82272, ISBN: 978-1-4200-8227-2 February 2010, 6-1/8 x 9-1/4, 168 pp. Suggested Price: $99.95 / £63.99

Catalog no. C7412, ISBN: 978-1-4200-7412-3 December 2009, 8-1/2 x 11, 507 pp. Suggested Price: $149.95 / £83.00

Biocatalysis and Agricultural Biotechnology

Development and Uses of Biofortified Agricultural Products

Edited by

Ching T. Hou

Gary S. Banuelos

United States Department of Agriculture, Peoria, Illinois, USA

USDA, ARS, Fresno, California, USA

Jei-Fu Shaw

Zhi-Qing Lin

National Chung Hsing University, Taichung, Taiwan

Southern Illinois University, Edwardsville, USA

With contributions from 55 distinguished international experts from all sectors of academia, industry, and government research institutes — a virtual who’s who among biocatalysis scientists — this book brings together current advances and in-depth reviews of biocatalysis and agricultural biotechnology, emphasizing bio-based products and agricultural biotechnology. Divided into two sections, it covers the latest research on improvements of agronomic and microbial traits and bio-based industry products. A reference for industrial science researchers, this text also serves as reference for graduate students others across bioscience.

Using a multidisciplinary approach, this volume provides new strategies and techniques for the production of biofortified agricultural products from different soils. Contributors from twelve countries explore the effects of environmental and biological factors on the accumulation and speciation of nutritionally important trace elements in agricultural products. They explore novel strategies regarding the functional foods and animal feed and other forms of biofortified agricultural products. The text addresses alternative biosources and bioproducts produced from phytoremediation processes as well as the bioavailability and the effects of bioproduct compounds.

Catalog no. 77031, ISBN: 978-1-4200-7703-2 April 2009, 6-1/8 x 9-1/4, 442 pp. Suggested Price: $179.95 / £109.00

Includes a CD-ROM

Biotechnology A Comprehensive Training Guide for the Biotechnology Industry Syed Imtiaz Haider and Anika Ashtok

Catalog no. 60058, ISBN: 978-1-4200-6005-8 October 2008, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $119.95 / £76.99

Digital Microfluidic Biochips Design Automation and Optimization Krishnendu Chakrabarty Duke University, Durham, North Carolina, USA

Tao Xu

Julphar Gulf Pharmaceutical Industries, United Arab Emirates

Cisco Systems, Cary, North Carolina, USA

Empowered with expert advice, this volume provides concise information covering the concepts and techniques needed to ensure product consistency, potency, efficacy, and safety in the biotechnology and biopharmaceutical industries. A valuable quality tool for both new and existing manufacturers, this text presents step-by-step guidance for optimizing research and maximizing expenditures so as to gain a competitive advantage. It discusses ways to avoid delays to market, reduce product and process failures, develop skilled employees, and maintain both local and international regulatory compliance. The book includes a companion CD-ROM that offers customizable training information.

Microfluidics-based biochips combine electronics with biochemistry for newly emerging application areas such as point-of-care medical diagnostics, on-chip DNA analysis, automated drug discovery, and protein crystallization. This book envisions an automated design flow for microfluidic biochips. It offers newly designed automation solutions for problems unique to digital microfluidics. The authors provide a comprehensive methodology for the automated design, test, and use of robust and low-cost manufactured digital microfluidic systems. Using real-life bioassays as examples, they offer a comprehensive set of practical methodologies and tools for chip design and manufacture.

Catalog no. 84488, ISBN: 978-1-4200-8448-1 April 2009, 7 x 10, 868 pp., Soft Cover Suggested Price: $99.95 / £60.99

Catalog no. K11010, ISBN: 978-1-4398-1915-9 April 2010, 6-1/8 x 9-1/4, 248 pp. Suggested Price: $139.95 / £89.00

Colloids in Biotechnology

Encyclopedia of Biotechnology in Agriculture and Food

Edited by

Monzer Fanun Al-Quds University, East Jerusalem, Israel Series: Surfactant Science

Colloids have come a long way from when Thomas Graham coined the term colloid to describe “pseudo solutions.” This book enables scientists to close the gap between extensive research and translation into commercial options in biomedicine and biotechnology. It covers biosurfactants and surface properties, phase behavior, and orientational change of surfactant mixtures with peptides at the interface. It also covers adsorption of polymers and biopolymers on the surface and interface, discusses colloidal nanoparticles and their use in biotechnology, and delves into bioadhesion and microencapsulation. A final section deals with nanofibre formation and the use of sol-gel in biotechnological applications. Catalog no. K11511, ISBN: 978-1-4398-3080-2 June 2010, 7 x 10, 700 pp. Suggested Price: $159.95 / £99.00

Biotechnology

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

Dennis R. Heldman Heldman Associates, San Marcos, California, USA

Focusing on the science and applications of molecular biology to agriculture and foods, this encyclopedia describes the new tools currently being used or being considered for use in the production of raw agricultural materials and the manufacturing of food products. 200 entries cover areas such as cloned animals, genetically modified and drought-resistant plants, biodiversity, and nutritionally enhanced foods. The encyclopedia explores media coverage of biotechnology, governmental regulations associated with it, consumer acceptance, and environmental issues. Illustrations and comprehensive references complement the text. Also available in an online format and in a combined print and online format

Catalog no. DK271X, ISBN: 978-0-8493-5027-6 June 2010, 8-1/2 x 11, 800 pp. Suggested Price: $320.00 / £204.00

For more information and a complete list

Essentials of Biotechnology R.C. Sobti and Suparna S. Pachouri

Handbook of New Technologies for Genetic Improvement of Legumes Edited by

P. B. Kirti

Biotechnology

Punjab University, India

University of Hyderabad, India

A comprehensive treatise on biotechnology, this volume starts with an overall review of early applications that scientists employed long before the field was defined. It then moves on to examine the emergence of current methods and specialized tools in the field, as well as cell culture and nucleic acid based technologies. It devotes individual chapters to biotechnology in the areas of health, agriculture, environment, aquaculture, and food. These are followed by chapters on the status of biotechnology in developing countries with special reference to India. It also discusses debated ethical considerations and explores ongoing issues regarding intellectual property rights and patents.

Comprehensive in its approach, this book presents the latest research on all aspects of genetically modified legume production. With contributions from over 90 international experts, this eye-opening resource offers an in-depth exploration of key topics such as genetic transformation technology, suppression-subtractive hybridization, c-DNA micro arrays, molecular mapping, tagging regulatory elements, and real-time PCR. The text also features a wealth of detailed references and informative tables to clearly explain pertinent data. With groundbreaking essays from some of the discipline’s most renowned experts, it is a source for upto-date accounts of genetic manipulation of their uses.

Catalog no. AB8284, ISBN: 978-1-4200-8284-5 November 2008, 7 x 9, 750 pp. Suggested Price: $119.95 / £76.99

Catalog no. HW13935, ISBN: 978-1-56022-308-5 May 2008, 6 x 9, 680 pp. Suggested Price: $139.95 / £89.00 Also Available in Soft Cover

Food Biotechnology Second Edition Edited by

Kalidas Shetty, Gopinadhan Paliyath, Anthony Pometto, and Robert E. Levin

Illustrated Dictionary of Biotechnology Himanshu Arora

University of Massachusetts, Amherst, USA Series: Food Science and Technology

Ane Books, India

Food Biotechnology, Second Edition demonstrates the massive effect that biotechnology has on food production and processing. The book begins with an overview of principles of microbiology, biochemistry, cell biology, and genetics. It continues with a review of food microbiology that analyzes the genetics and processes of dietary fundamentals including dairy starter cultures, lactic acid bacteria, baker’s yeast, and wine. The next section discusses dairy and animal foods, and proceeds with an examination of plants and algal systems. It explores food safety and diagnostics, and functional foods. The volume concludes with descriptions of novel bioprocessing applications and regulatory and patent issues.

Helping to support a common language in this rapidly evolving field, the Illustrated Dictionary of Biotechnology includes a range of terms wide enough to satisfy the needs of any researcher, clinician, lawyer, investor, student, or instructor whose work involves contact with new advances in science and medicine. In clear, concise language, it provides straightforward definitions and invaluable background information so that even complex terms require only a rudimentary understanding of the life sciences. Extensive cross-referencing expands individual definitions and enable readers to follow a chosen theme. Illustrations are included where they enhance understanding.

Catalog no. DK3098, ISBN: 978-0-8247-5329-0 October 2005, 7 x 10, 2008 pp. Suggested Price: $470.00 / £299.00

Catalog no. N10040, ISBN: 978-1-4398-0173-4 April 2009, 6-1/8 x 9-1/4, 450 pp., Soft Cover Suggested Price: $59.95 / £33.99

Textbook

Fundamentals of Microfluidics and Lab on a Chip for Biological Analysis and Discovery

Second Edition

Paul C.H. Li

Introduction to Biology and Biotechnology Edited by

Simon Fraser University, Burnaby, British Columbia, Canada

K. Vaidyanath, K. Patrap Reddy, and K. Satya Prasad

This comprehensive textbook presents the fundamentals of microfluidic lab-on-achip systems and provides an overview of the available technology, its limitations, and its breakthroughs. It emphasizes analytical applications of microfluidic technology and provides in-depth coverage of micromachining, nucleic acids, and mass spectrometry. It also covers more recent advances in microdrops and nanoparticles. Ideal for students, the text includes historical background, expanded problem sets in each chapter, a comprehensive glossary, a complete index, and extensive references. A solutions manual is available upon qualifying course adoption.

Covering all aspects of basic microbial, plant, animal, and human biology, Introduction to Biology and Biotechnology describes the linkage of biological principles to plant, animal, environmental, industrial, and medical biotechnologies. It discusses the basic concepts of genetics and molecular biology and examines technological developments in the production of biopolymers. It also examines advances made in vaccines, gene therapy, bioremediation, biofuels, and biofertilizers.

Catalog no. K10977, ISBN: 978-1-4398-1855-8 February 2010, 7 x 10, Soft Cover Suggested Price: $99.95 / £38.99

Catalog no. N10069, ISBN: 978-1-4398-0724-8 February 2009, 7 3/8 x 9 1/4, 625 pp. Suggested Price: $79.95 / £41.99

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Two-Volume Set Edited by

Christina D. Smolke Stanford University, California, USA Series: Metabolic Pathway Engineering Handbook

Christina Smolke, who recently developed a novel way to churn out large quantities of drugs from genetically modified brewer’s yeast, is regarded as one of the most brilliant new minds in biomedical engineering. In The Metabolic Pathway Engineering Handbook, she brings together pioneering scientists from numerous disciplines to provide a complete record of accomplishment in metabolic pathway engineering. With a wealth of cutting edge research and analysis, this work is an invaluable resource for those seeking to add their own contributions. Organized by topic, this reference is available as two volumes that can be purchased individually or as a set.

Save on the set! Catalog no. 3923, ISBN: 978-0-8493-3923-3 August 2009, 7 x 10, 3000 pp. Suggested Price: $199.95 / £121.00

Also available in individual volumes

Fundamentals The Metabolic Pathway Engineering Handbook: Fundamentals provides an overview of the field with a look towards the future. It discusses cellular metabolism, including transport processes inside the cell and energy generating reactions, as well as rare metabolic conversions. This volume also explores balances and reaction models, the regulation of metabolic pathways, and genome scale and multiscale modeling tools. In addition, it covers the development of appropriate hosts for metabolic engineering, including the use of Escherichia coli, Bacillus subtilis, Streptomyces, yeast, filamentous fungi, and mammalian cells using cell culture. Catalog no. K10164, ISBN: 978-1-4398-0296-0 July 2009, 7 x 10, 678 pp. Suggested Price: $159.95 / £99.00

Advances in Chromatography Edited by

Eli Grushka Hebrew University of Jerusalem, Israel

Nelu Grinberg Boehringer-Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA Series: Advances in Chromatography

Advances in Chromatography, Volume 48 For more than four decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. Topics covered in this new edition include new advances in characterization of stationary phases in supercritical fluid chromatography with the solvation parameter model, affinity interaction chromatography, high-throughput methods for microbial metabolome analysis using gas chromatography/mass spectrometry, simulated moving bed processes, retention mechanism in RP, solid phase micro extraction, silica hydride chemistry and applications, and UPLC. Catalog no. 84534, ISBN: 978-1-4200-8453-5 December 2009, 6-1/8 x 9-1/4, 404 pp. Suggested Price: $199.95 / £127.00

Advances in Chromatography, Volume 47 Each author’s clear presentation of topics and vivid illustrations make the material in Advances in Chromatography: Volume 47 accessible and engaging to biochemists and analytical, organic, polymer, and pharmaceutical chemists at all levels. Covering the state of the art in separation science, this volume presents timely, cutting-edge reviews on chromatography in the fields of bio-, analytical, organic, polymer, and pharmaceutical chemistry. Chapters in this volume discuss countercurrent chromatography and large-scale genotyping as well as cyclic voltammetry detection, a powerful tool for determining the electrochemical characteristics of organic compounds. Catalog no. 60368, ISBN: 978-1-4200-6036-2 February 2009, 6-1/8 x 9-1/4, 462 pp. Suggested Price: $189.95 / £115.00

Tools and Applications The Metabolic Pathway Engineering Handbook: Tools and Applications delves into evolutionary tools and gene expression tools for metabolic pathway engineering. It covers applications of emerging technologies, including recent research on genome-wide technologies, DNA and phenotypic microarrays, and proteomics tools for experimentally determining flux through pathways. This volume also looks at emerging applications for producing fine chemicals, drugs, and alternative fuels. Catalog no. 77651, ISBN: 978-1-4200-7765-0 July 2009, 7 x 10, 581 pp. Suggested Price: $159.95 / £99.00

Biomolecular EPR Spectroscopy Wilfred Raymond Hagen Delft University of Technology, The Netherlands

Biomolecular EPR spectroscopy is widely used for the structural, functional, and analytical analysis of paramagnetic molecules in the biochemistry of all species and in related fields. This volume presents comprehensive, up-to-date coverage of the theory of spectroscopy and its applications to biological systems. The underlying quantum mechanics is introduced, assuming no previous knowledge but offering rigorous treatment. The author provides practical tips and recommendations based on his 30 years of experience in the field. The text also includes supporting software with simple graphical user interfaces to allow readers to tackle most of the problems faced in spectral analysis. Catalog no. 59572, ISBN: 978-1-4200-5957-1 December 2008, 6-1/8 x 9-1/4, 248 pp. Suggested Price: $139.95 / £89.00

Biotechnology / Methods & Instrumentation

The Metabolic Pathway Engineering Handbook

For more information and a complete list Chiral Separations by Capillary Electrophoresis Edited by

Ann Van Eeckhaut and Yvette Michotte

Edited by

Ammasi Periasamy University of Virginia, Charlottesville, USA

Methods & Instrumentation

Vrije Universiteit Brussel, Belgium Series: Chromatographic Science Series, 100

Robert M. Clegg

This volume provides a comprehensive, up-to-date overview of the principles of chiral separation by capillary electrophoresis and the different chiral selectors available. It discusses the most important as well as several new chiral selectors used in capillary electrophoresis. The book reviews recent pharmaceutical and biomedical applications and explores novel techniques, such as capillary electrophoresis coupled to mass spectrometry and microchip technology. It also examines quantitative aspects, the possibilities of capillary electrochromatography, and the various chiral columns that are available.

Suitable for a variety of applications in biology and biomedical research, fluorescence lifetime imaging (FLIM) is a powerful new tool for advanced quantitative analysis. Its high contrast and sensitivity allow for the detection of signals at the single molecule level. After an overview of basic principles of fluorescence, microscopy, and FLIM, this book discusses probes, dynamic and video rate FLIM imaging, laser scanning confocal FLIM, spectral lifetime imaging, nonlinear curve-fitting methods, global FLIM data analysis, and new approaches in data analysis. Widely recognized as pioneers in the field, the editors offer a summary chapter on current FLIM applications.

Catalog no. 69330, ISBN: 978-1-4200-6933-4 November 2009, 6-1/8 x 9-1/4, 543 pp. Suggested Price: $169.95 / £108.00

Color Atlas and Manual of Microscopy for Criminalists, Chemists, and Conservators Nicholas Petraco and Thomas Kubic

FLIM Microscopy in Biology and Medicine

University of Illinois, Urbana, USA

Catalog no. C7890, ISBN: 978-1-4200-7890-9 July 2009, 7 x 10, 472 pp. Suggested Price: $99.95 / £63.99

Handbook of Capillary and Microchip Electrophoresis and Associated Microtechniques Third Edition Edited by

James P. Landers

John Jay College, New York, USA

University of Virginia, Charlottesville, USA

Color Atlas and Manual of Microscopy for Criminalists, Chemists, and Conservators offers more than 400 color photomicrographs of the most commonly encountered materials to facilitate specimen comparison and rapid identification of organic and inorganic fibers and particles. In a single source, this book presents a range of simple methods to help readers quickly characterize and identify a broad range of materials. Covering substances such as hair and fibers, minerals and soils, paints, drugs, and dust, the book presents the basic principles of microscopy and directions for sample preparation and examination.

Now in its third edition, this bestselling work continues to offer state-of-the-art information on the development and employment of capillary electrophoresis. With special emphasis on microseparations and microfluidics, it features new chapters describing the use of microchip electrophoresis and associated microtechniques, with a focus on the extraordinary breadth of work undertaken to expand CE methodologies in recent years. Enhanced by contributions from leading international experts, the Handbook of Capillary and Microchip Electrophoresis and Associated Microtechniques, Third Edition remains a seminal reference for the chemistry, biology, and engineering fields.

Catalog no. 1245, ISBN: 978-0-8493-1245-8 September 2003, 287x215, 313 pp. Suggested Price: $209.95 / £134.00

Encyclopedia of Chromatography Third Edition Edited by

Jack Cazes

Catalog no. 3329, ISBN: 978-0-8493-3329-3 December 2007, 7 x 10, 1592 pp. Suggested Price: $209.95 / £134.00

Handbook of Cryo-Preparation Methods for Electron Microscopy Edited by

Annie Cavalier, Daniele Spehner, and Bruno M. Humbel

Lady Lake, Florida, USA

Series: Methods in Visualization

Revised and expanded, this third edition is an authoritative source of information for researchers in chemistry, biology, physics, engineering, and materials science. This guide to specific chromatographic techniques and theory provides a basic introduction to the science and technology, offering key references dealing with the methodology for analysis of specific chemicals and applications in industry. With a focus on emerging technologies, the text contains tables and figures that cogently illustrate and clarify technical points. The book is a valuable, readerfriendly reference for all those who employ chromatographic methods for analysis of complex mixtures of substances, as well as practitioners across the entire spectrum of science.

The last two decades have seen exponential growth in cryo-electron microscopy, resulting in exciting advances, new hypotheses, and a better understanding of the ultrastructure of living and inert matter. Using a step-by-step format, this handbook presents the most sophisticated methods used in research laboratories. It describes the basic principles of cryo-fixation, cryo-ultramicrotomy, embedding at low temperatures and freeze-fracture. It also explores electron crystallography, 2D/3D structure analysis, cryo-electron tomography, and techniques for protein localization. Each chapter includes detailed protocols, summary tables, and illustrations to clarify the techniques.

Also available in an online format and in a combined print and online format Catalog no. 84593, ISBN: 978-1-4200-8459-7 October 2009, 8-1/2 x 11, 2850 pp. Suggested Price: $590.00 / £376.00

Catalog no. 7227, ISBN: 978-0-8493-7227-8 October 2008, 7 x 10, 704 pp. Suggested Price: $179.95 / £114.00

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Third Edition Edited by

Donald A. Burns NIR Resources, Los Alamos, New Mexico, USA

Emil W. Ciurczak Cadrai Technologies, Goldens Bridge, New York, USA Series: Practical Spectroscopy

Presenting nearly 50 percent revised material, this edition combines concise theoretical foundations with the latest advances in instrumentation, computerization, calibration, and methods in NIR spectroscopy. Drawing on the experience of more than 60 experts in the field, it underscores accurate as well as time- and cost-effective current trends in sample preparation, calibration transfer, process control, data analysis, and commercial NIR instrumentation. Chapters new to the third edition highlight novel applications in pharmaceuticals, polymers, plastics, petrochemicals, textiles, foods and beverages, baked products, agricultural products, biomedicine, neutraceuticals, and counterfeit detection. Catalog no. 7393, ISBN: 978-0-8493-7393-0 September 2007, 7 x 10, 826 pp. Suggested Price: $229.95 / £146.00

Handbook of Optical Sensing of Glucose in Biological Fluids and Tissues Edited by

Valery V. Tuchin

Ion-Pair Chromatography and Related Techniques Teresa Cecchi Istituto Tecnico Industriale Statale Montani, Fermo, Italy Series: Analytical Chemistry, 8

Ion-Pair Chromatography (IPC) is a rapidly evolving method for difficult analyses of organic and inorganic ions and ionogenic, neutral, and zwitterionic compounds. Providing a thorough exploration of the multiplicity of interactions involved in an IPC system, this book emphasizes the progress from theoretical modeling to application. It explores the practical potential of IPC in a number of sectors and examines the upgrade of column technology and instrumentation to improve data quality and to increase sample throughput. The book also compares IPC to other instrumental methods of analysis and discusses the rising importance of the ion-pair concept in different analytical techniques. Catalog no. K10075, ISBN: 978-1-4398-0096-6 October 2009, 6-1/8 x 9-1/4, 215 pp. Suggested Price: $129.95 / £82.00

Mass Spectrometry of Nucleosides and Nucleic Acids Edited by

Joseph H. Banoub Fisheries and Oceans Canada, Science Branch and Memorial University of Newfoundland, Canada

Saratov State University, Russia Series in Medical Physics and Biomedical Engineering

Patrick A. Limbach

With an extensive list of references on glucose sensing, glucose monitoring, and light-tissue interaction, this handbook analyzes trends in noninvasive optical glucose sensing and discusses its impact on tissue optical properties. It presents an up-to-date review of commercialized glucose sensors and the underlying science behind their functionality, discusses the fundamentals and basic research of light-tissue interaction, and describes biological fluids that contain glucose on physiological and hyperphysiological levels. The book also details new optical techniques for glucose diffusion coefficient measurements in human tissues and explains glucose-induced optical clearing effects in tissue and blood.

This volume summarizes and reviews the latest developments in the field of nucleic acid research by mass spectrometry and provides a window on the next generation of analysis. It highlights the most popular ionization methods and illustrates the diverse strategies used in the characterization and sequencing of novel nucleosides and nucleotides. It also covers deoxyribonucleic acid (DNA), DNA-adducts, DNA-drug complexes, ribonucleic acid (RNA) oligomers of biomedical importance, RNA-protein complexes, and post-transcriptional modifications. The contributions presented in this volume capture the range of these advances, helping to inspire new findings and avenues of research.

Catalog no. C9748, ISBN: 978-1-58488-974-8 December 2008, 6-1/8 x 9-1/4, 744 pp. Suggested Price: $129.95 / £82.00

Catalog no. 44028, ISBN: 978-1-4200-4402-7 December 2009, 7 x 10, 504 pp. Suggested Price: $149.95 / £95.00

University of Cincinnati, Ohio, USA

Textbook Textbook

An Introduction to Microscopy Suzanne Bell and Keith Morris

Measurement and Detection of Radiation Second Edition Nicholas Tsoulfanidis

West Virginia University, Morgantown, USA

University of Nevada, Reno, USA

Microscopy is an invaluable tool in biology and healthcare and increasingly is integrated into modern chemical instrumentation. This text builds a foundation in the basics of light and polarizing microscopy. The book focuses on forensic science applications and also explores applications in other disciplines. Chapters detail topics ranging from basic theoretical knowledge to advanced subjects such as electron and confocal microscopy and fluorescence. Numerous figures and photographs supplement the text and explain the principles and procedures introduced.

Assuming a basic knowledge of calculus, differential equations, and some atomic physics, this classic bestseller enables students to select the proper detector, analyze the results of counting experiments, and perform radiation measurements following proper health physics procedures. Examples and problems in each chapter ensure that students understand the concepts presented. The book cover long-range alpha detector LRAD, pure geranium detectors, magnetic and electrostatic spectrometers, position-sensitive detectors, the LSL-M2 unfolding code, compensated ion chambers, self-powered neutron detectors, new protection guides, and exposure limits. A solutions manual is available for qualifying instructors.

Catalog no. 8450X, ISBN: 978-1-4200-8450-4 October 2009, 6-1/8 x 9-1/4, 180 pp. Suggested Price: $69.95 / £44.99

Methods & Instrumentation

Handbook of Near-Infrared Analysis

Catalog no. GS857, ISBN: 978-1-56032-317-4 March 1995, 6 x 9, 636 pp. Suggested Price: $175.95 / £111.00

For more information and a complete list The Measurement, Instrumentation and Sensors Handbook

Methods & Instrumentation / Nanobiotechnology 58

Edited by

John G. Webster University of Wisconsin, Madison, USA Series: Electrical Engineering Handbook, 14

Two-Dimensional Optical Spectroscopy Minhaeng Cho Korea University, Seoul

Edited by one of the most renowned instrumentation experts in the world, this best-selling handbook contains nearly 150 contributions covering all aspects of the design and implementation of instrumentation. It describes the use of instruments and techniques for performing practical measurements in engineering, physics, chemistry, and the life sciences. Organized according to measurement problem, each section addresses the different ways of making a measurement for a given variable. Each chapter presents basic information, a detailed mathematical treatment, and advanced applications, evaluative opinions, and areas for future study.

Effectively introducing a newly developed research field, this book provides a detailed account of basic theory required for an understanding of two-dimensional vibrational and electronic spectroscopy. It also bridges the gap between the formal development of nonlinear optical spectroscopy and the application of the theory to explain experimental results. The author presents novel definitions and theoretical frameworks for linear and nonlinear response spectroscopy and describes a range of two-dimensional spectroscopic techniques to compare the merits and disadvantages of each technique. He also includes various examples and applications to real molecular and electronic systems.

Catalog no. 8347, ISBN: 978-0-8493-8347-2 December 1998, 7 x 10, 2630 pp. Suggested Price: $209.95 / £134.00

Catalog no. 84291, ISBN: 978-1-4200-8429-0 June 2009, 6-1/8 x 9-1/4, 385 pp. Suggested Price: $139.95 / £85.00

Pharmaceutical and Medical Applications of Near-Infrared Spectroscopy Emil W. Ciurczak

Using Mass Spectrometry for Drug Metabolism Studies

Cadrai Technologies, Golden’s Bridge, New York, USA

Second Edition

Gary E. Ritchie

Edited by

United States Pharmacopeia, Rockville, Maryland, USA Series: Practical Spectroscopy, 31

Walter A. Korfmacher

Now in its second edition, this volume provides focused coverage of the instrumentation, computerization, calibration, and methods development of NIR spectroscopy. It examines novel applications for accurate time- and costeffective analyses of pharmaceuticals as well as biomedical applications. Fully updated, the book contains entirely new chapters on the theory of diffuse reflection, the calibration and validation of process sensors, the new field of PAT (Process Analytical Technologies) in pharmaceutical applications, nutraceuticals, detection of counterfeit drugs, NIR spectrometry of abdominal aortic aneurysm, and new chemometric methods for biomedical components in blood and control serum.

The first edition of this now classic work helped establish mass spectrometry as the premier tool for drug metabolism studies. Keeping pace with rapid advances, the emergence of new approaches, and increasing demands by vendors, the second edition of this bestseller includes cutting-edge coverage of new instrumentation and software as well as significant new information on the latest findings regarding biomarkers and metabolomics. In addition to exploring all modern techniques and strategies, it offers an excellent overview of the entire drug discovery process, including the latest developments in molecular research.

Catalog no. 84143, ISBN: 978-1-4200-8414-6 April 2010, 7 x 10, 350 pp. Suggested Price: $159.95 / £99.00

Schering-Plough Research Institute, Kenilworth, New Jersey

Catalog no. 92200, ISBN: 978-1-4200-9220-2 November 2009, 6-1/8 x 9-1/4, 451 pp. Suggested Price: $169.95 / £108.00

Sensors for Chemical and Biological Applications Edited by

Manoj Kumar Ram

Biomedical Nanotechnology

Eclipse Energy Systems, Inc, St. Petersburg, Florida, USA

Edited by

Venkat R. Bhethanabotla

Neelina H. Malsch

University of South Florida, Tampa, USA

Malsch TechnoValuation, Utrecht, The Netherlands

This reference supplies versatile, hands-on tools for professionals working in a broad array of disciplines. Sensors for Chemical and Biological Applications offers a detailed discussion of the potential of chemical and biochemical sensors in medical science, food quality, biological, and environmental applications. Examining the role of nanotechnology in sensor development, it explores how sensors confront challenges of chemical-bioterrorism through enhanced specificity, fast response times, and the ability to determine multiple hazardous substances. It also includes practical examples of sensor usage such as cholesterol monitoring along with extensive references.

This work focuses on the biomedical applications of nanotechnology in three areas: nanodrugs and drug delivery; prostheses and implants; and diagnostics and screening technologies. Describing the nanotechnology applications associated with each, leading experts discuss research, including their own, which involves gene therapy, cancer treatments, hip replacement coatings, cantilever biochemical sensors, and lab-on-a-chip techniques. Along with the technical discussion, Biomedical Nanotechnology presents an illuminating discourse on this technology, discussing potential and perceived risks, while also addressing the social and economic context of nanotech research.

Catalog no. 3366, ISBN: 978-0-8493-3366-8 January 2010, 6-1/8 x 9-1/4, 384 pp. Suggested Price: $129.95 / £82.00

Catalog no. DK2453, ISBN: 978-0-8247-2579-2 April 2005, 6-1/8 x 9-1/4, 232 pp. Suggested Price: $144.95 / £92.00

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Nanotech 2010

Edited by

Nanoscience and Technology Institute Cambridge, Massachusetts, USA

Arguably the largest and most well-attended international nanotechnology conference in the world, Nanotech brings together specialists from a wide range of fields of science, technology, and business. Its attendees include business executives, venture capatilists, politicians, scientists, and researchers from more than 70 countries, reflecting the reach of nanotechnology and the innovations it brings. These three volumes contain the latest information on how nanotechnology is revolutionizing medicince, science, pharmaceuticals, robotics, electronics, manufacturing, and computer technology.

Buy the set and save! Catalog no. N10234, ISBN: 978-1-4398-3418-3 June 2010, 2076 pp., Soft Cover, Suggested Price: $550.00 / £350.00

Bionanotechnology Global Prospects Edited by

David E. Reisner The Nano Group, Inc., Farmington, Connecticut, USA

As the impact of nanotechnology continues to grow, it is important for the modern biomedical engineer to have a deeply rooted understanding of bionanotechnologies. Featuring chapters drawn from the third edition of the best-selling Handbook of Biomedical Engineering as well as new contributions not found in the Handbook, Bionanotechnology takes a broad survey of the current research and activities that are shaping this burgeoning field. Covering both technical and non-technical areas, the book discusses the role of nanotechnology in novel medical devices, bioanalytical technologies, and nano-biomaterials as well as intellectual property issues that are unique to nanotechnologies. Catalog no. 7528, ISBN: 978-0-8493-7528-6 July 2008, 7 x 10, 368 pp. Suggested Price: $89.95 / £57.99

Also available on CD-ROM!

Catalog no. N10236, ISBN: 978-1-4398-3421-3 June 2010, CD-ROM, Suggested Price: $550.00 / £350.00

Nanobiotechnology

Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, Three-Volume Set

Textbook Also available as individual volumes Fabrication, Particles, Characterization, MEMs, Electronics and Photonics; Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, Volume 1 Catalog no. N10231, ISBN: 978-1-4398-3401-5 June 2010, 8-1/2 x 11, 748 pp., Soft Cover Suggested Price: $199.95 / £127.00

Life Sciences, Medicine, Diagnostics, Bio Materials and Composites; Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, Volume 2 Catalog no. N10232, ISBN: 978-1-4398-3402-2 June 2010, 8-1/2 x 11, 636 pp., Soft Cover Suggested Price: $199.95 / £127.00

Biofuels, Renewable Energy, Coatings and Compact Modeling; Technical Prceedings of the 2010 NSTI Nanotechnology Conference adn Expo, Volume 3 Catalog no. N10233, ISBN: 978-1-4398-3415-2 June 2010, 6-1/8 x 9-1/4, 742 pp., Soft Cover Suggested Price: $199.95 / £127.00

Fundamentals of Nanotechnology Gabor L. Hornyak, John J. Moore, H.F. Tibbals, and Joydeep Dutta Asian Institute of Technology, Pathumthani, Thailand

Nanotechnology is no longer a subdiscipline of chemistry, engineering, or any other field. It represents the convergence of many fields, and therefore demands a new paradigm for teaching. This CHOICE award winning textbook is for the next generation of nanotechnologists. It surveys the field’s broad landscape, exploring the physical basics such as nanorheology, nanofluidics, and nanomechanics as well as industrial concerns such as manufacturing, reliability, and safety. The authors explore the vast range of nanomaterials and systematically outline devices and applications in various industrial sectors. This color text is an ideal companion to Introduction to Nanoscience by the same group of esteemed authors. Catalog no. 48031, ISBN: 978-1-4200-4803-2 December 2008, 7 x 10, 786 pp. Suggested Price: $89.95 / £39.99

Nanotechnology in Biology and Medicine Methods, Devices, and Applications Edited by

Tuan Vo-Dinh Duke University, Durham, North Carolina, USA

Proceedings from preceding years are also available online at crcpress.com

The latest generation of nanodevices enables scientists to more accurately detect, analyze, and manipulate nanostructures at the molecular level. With emphasis on the application and design of nanomaterials, devices, and sensors, this book carefully details methods, protocols, and instrumentation for biomedical applications such as stem cell research, gene diagnostics, targeted drug delivery, and tissue engineering. Pioneers in the field offer a cohesive compilation of data, practical tool kits, references, and experimental insight on relevant topics, including self-assembly, bio-inspired materials, and biomanufacturing. Catalog no. 2949, ISBN: 978-0-8493-2949-4 January 2007, 7 x 10, 792 pp. Suggested Price: $154.95 / £98.00

For more information and a complete list Particulate Systems in Nano- and Biotechnologies

Scaffolding In Tissue Engineering

Edited by

University of Michigan, Ann Arbor, USA

Nanobiotechnology / Tissue Engineering

Wolfgang Sigmund, Hassan El-Shall, Dinesh O. Shah, and Brij M. Moudgil University of Florida, Gainesville, USA

Edited by

Peter X. Ma Jennifer Elisseeff Johns Hopkins University, Baltimore, Maryland, USA

Viewing recent advancements in absorbed films and particle technology as a foundation for nano- and biotechnology innovations, Particulate Systems in Nano- and Biotechnologies offers comprehensive coverage of important topics in this area and summarizes developments occurring worldwide over the past decade. International experts from European, Australian, Asian, and North American research centers — including the National Science Foundation’s Engineering Research Center for Particle Science and Technology — offer critical perspectives in relation to each of their specific research areas, examine the current status of technology, and define the challenges that future research must address.

A standard reference in the library of leading research efforts and university programs dedicated to scaffolding design and regenerative medicine, Scaffolding in Tissue Engineering reviews the general principles of tissue engineering and examines methods and applications for a broad range of tissue engineering scaffolds. It presents an in-depth exploration of traditional and novel materials and fabrication technologies, including three-dimensional scaffold design, structural and functional scaffold modification, and various tissue engineering trends and applications. The book offers insight into new trends in scaffold development and the ever-expanding range of tissue engineering applications.

Catalog no. 7436, ISBN: 978-0-8493-7436-4 December 2008, 6-1/8 x 9-1/4, 385 pp. Suggested Price: $149.95 / £95.00

Catalog no. DK3367, ISBN: 978-1-57444-521-3 August 2005, 7 x 10, 656 pp. Suggested Price: $195.95 / £127.00

Biomaterials and Tissue Engineering in Urology

Tissue Engineering John P. Fisher University of Maryland, College Park, USA

Edited by

Antonios G. Mikos

John Denstedt

Rice University, Houston, Texas, USA

University of Western Ontario. Canada

Joseph D. Bronzino

Anthony Atala

Trinity College, Hartford, Connecticut, USA

Wake Forest University, Winston-Salem, North Carolina, USA

An invaluable resource for clinicians as well as for researchers in materials and biomedical devices, this text summarizes recent research on the use of biomaterials and tissue engineering in the treatment of urological disorders. The first section reviews the fundamentals, including biofilms and encrustation formation. The next part discusses recent advances in biomaterials and the design of urological devices such as metal ureteral stents, self-lubricating catheter materials, and penile implants. The final section addresses urological tissue engineering, covering artificial and natural biomaterials, nanotechnology, and placental stem cells used for the regeneration of urological tissue and organs.

The ability to engineer biocompatible tissue is the hallmark of modern biomedical engineering, integrating all aspects of every sub-discipline in the field. Featuring chapters drawn from the third edition of the best-selling Handbook of Biomedical Engineering as well as new contributions not found in the Handbook, Tissue Engineering surveys the latest advances in this relatively young area. The book discusses the fundamental concepts of tissue engineering, enabling technologies, and tissue engineering applications. It examines strategies that incorporate scaffolds, nanocomposites, bioreactors, drug delivery systems, and gene therapy techniques that are being applied in regenerative medicine.

Catalog no. N10041, ISBN: 978-1-4398-0177-2 June 2009, 6 x 9, 500 pp. Suggested Price: $247.95 / £150.00

Catalog no. 9026, ISBN: 978-0-8493-9026-5 May 2007, 7 x 10, 600 pp. Suggested Price: $93.95 / £59.99

Nanotechnology and Tissue Engineering Edited by

Tissue Engineering and Artificial Organs

Cato Laurencin

Edited by

The Scaffold University of Virginia, Charlottesville, USA

Lakshmi Nair University of Connecticut, Farmington, USA

With chapters written by world famous researchers involved with various facets of nanostructured scaffolds, this is the first resource that brings together current research and background information on a complete range of engineering processes that have led to the development of a number of highly useful tissues. It details the fundamental and advanced aspects of nanofabrication and includes an examination of cellular interactions at the nanoscale level. This highly comprehensive resource also discusses clinical implications and applications, making it a work of importance for clinicians, as well as an essential reference for engineers and other scientists seeking to further advance the field. Catalog no. 51822, ISBN: 978-1-4200-5182-7 June 2008, 7 x 10, 384 pp. Suggested Price: $149.95 / £95.00

Joseph D. Bronzino Trinity College, Hartford, Connecticut, USA Series: The Biomedical Engineering Handbook, Third Edition

Reviewing applications at the leading edge of modern biomedical engineering, Tissue Engineering and Artificial Organs explores transport phenomena, biomimetics systems, biotechnology, prostheses, artificial organs, and ethical issues. The book integrates coverage of life sciences with a section on molecular biology, and also includes a section on bionanotechnology. New technologies and methods spawned by biomedical engineering have the potential to improve the quality of life for everyone, and this volume from the The Biomedical Engineering Handbook sheds light on the tools that will enable these advances. For information on the complete Handbook, see page 45. Catalog no. 2123, ISBN: 978-0-8493-2123-8 May 2006, 7 x 10, 1304 pp. Suggested Price: $134.95 / £86.00

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

Second Edition

Fate of Pharmaceuticals in the Environment and in Water Treatment Systems

James E. DeMuth

Edited by

University of Wisconsin - Madison, USA Series: Chapman & Hall/CRC Biostatistics Series, 2

Diana S. Aga

Focusing on applications to research, clinical trials, and quality control, Basic Statistics & Pharmaceutical Statistical Applications is a practical, easy-to-use text and reference that builds a basic knowledge of statistics. Accessible and nonthreatening, it discusses all of the commonly used statistical tests and presents them with examples and worked-out results. The emphasis is on correctly interpreting research results rather than on theory. Thoroughly revised and expanded, this edition includes chapters on measures of associations, odds and relative risks ratios, and survival statistics. Other added material addresses process capability, tolerance limits, and reproducibility.

Written by experts from academia, government, and industry, this book provides a well-balanced, multidisciplinary perspective on the issues, discussing topics ranging from field studies documenting the occurrence of pharmaceuticals in environmental compartments, to laboratory studies determining the degradation kinetics and formation of by-products during treatment. The text provides data to help scientists, regulators, and engineers understand the factors that affect the environmental fate of pharmaceuticals in soil and water, facilitate the development of best management practices, and optimize treatment systems for removal of these compounds from the environment.

Catalog no. DK799X, ISBN: 978-0-8493-3799-4 May 2006, 6-1/8 x 9-1/4, 744 pp. Suggested Price: $89.95 / £39.99

Catalog no. 52322, ISBN: 978-1-4200-5232-9 December 2007, 6 x 9, 408 pp. Suggested Price: $144.95 / £92.00

Cleaning Validation Manual

Implementing Quality in Laboratory Policies and Processes

Basic Statistics and Pharmaceutical Statistical Applications

A Comprehensive Guide for the Pharmaceutical and Biotechnology Industries Syed Imtiaz Haider and Erfan Syed Asif Julphar Gulf Pharmaceutical Industries, United Arab Emirates

With more than 20 easy-to-use template protocols for cleaning validation of extensively used equipment, this book provides technical solutions to assist in fulfilling the training needs of finished pharmaceutical manufacturers. Drawing on the authors’ more than two decades of experience, the text offers hands-on training based on current approaches and techniques. The manual is organized as a database to support those involved in the development, manufacturing, auditing, and validation of bio-pharmaceuticals on a pilot scale, that can lead to scaled-up production. It also provides exclusive training guidelines in a CDROM to enable the users to amend or adapt processes as necessary. Catalog no. K11299, ISBN: 978-1-4398-2660-7 January 2010, 7 x 10, 450 pp. Suggested Price: $159.95 / £99.00

CRC Handbook of Chemistry and Physics 91st Edition Edited by

William M. Haynes National Institute of Standards and Technology, Boulder, Colorado, USA

Mirroring the growth and direction of science for a century, the CRC Handbook of Chemistry and Physics, now in its 91st edition, continues to be the most accessed and respected scientific reference in the world, used by both students and Nobel Laureates. Available in its traditional print format, the Handbook is also available as an innovative interactive product on CD and online. This year’s edition adds many new tables and major revisions, including the stopping power of electrons, physical properties of selected polymers, properties of ice and super cooled water, and many, many more. A carbon footprint calculator is also in the works. Catalog no. K11100, ISBN: 978-1-4398-2077-3 June 2010, 8-1/2 x 11, 2800 pp. Suggested Price: $149.95 / £95.00

Handbook of Chemistry and Physics CD-ROM, Version 2010

Catalog no. K10911, ISBN: 978-1-4398-1755-1, August 2009 Suggested Price: $169.95 / £109.00

University at Buffalo, New York, USA

General References

Textbook

Using Templates, Project Management, and Six Sigma Edited by

Donnell R. Christian, Jr., and Stephanie Drilling Professional Business Solutions, O’Fallon, Missouri, USA

To gain accreditation, every laboratory must have a superior quality assurance program based upon a documented set of operational and technical manuals. This volume provides templates for the various policies, procedures, and forms that should be contained in the manuals of a laboratory seeking accreditation. It begins with a general introduction and overview of quality assurance and then moves on to cover implementation strategies. It contains best practices and templates for the project management of the design and implementation of the laboratory quality assurance manual and procedures. The book also examines how Six Sigma concepts can be used to optimize laboratories. Catalog no. 73044, ISBN: 978-1-4200-7304-1 November 2009, 7 x 10, 1432 pp. Suggested Price: $636.00 / £405.00

Multiple Testing Problems in Pharmaceutical Statistics Edited by

Alex Dmitrienko, Ajit C. Tamhane, and Frank Bretz Series: Chapman & Hall/CRC Biostatistics Series, 33

Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical industry, academia, and regulatory agencies, this volume explores the rapidly growing area of multiple comparison research with an emphasis on pharmaceutical applications. It describes important multiplicity problems encountered in pre-clinical and clinical trial settings. The book includes numerous case studies from actual pre-clinical experiments and clinical trials to help readers quickly learn common multiple testing methods and apply them to real-life problems. It also reviews relevant regulatory guidelines and implements the methods using SAS and R. The data sets and code are available on the book’s website. Catalog no. C9845, ISBN: 978-1-58488-984-7 December 2009, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $89.95 / £57.99

For more information and a complete list

Pharmaceutical Packaging Technology

General References / Biopharmaceuticals 62

D A Dean, E R Evans, and I H Hall

Biopharmaceuticals in Plants Toward the Next Century of Medicine Kathleen Laura Hefferon

Fisons Place, Ipswich, UK

Cornell University, Ithaca, New York, USA

Pharmaceutical packaging requires a greater knowledge of materials and a greater intensity of testing than most other packed products, not to mention a sound knowledge of pharmaceutical products and an understanding of regulatory requirements. Structured to meet the needs of the global market, this volume provides an assessment of a wide range of issues. It covers the entire supply chain from conversion of raw materials into packaging materials and then assembled into product packs. Integrating information from many drug delivery systems, the author discusses testing and evaluation and emphasizes traceability and the need to for additional safeguards.

Designed as a basic reference for researchers in a wide variety of disciplines, this book discusses plant transformation techniques, the generation of transgenic plants, and the engineering of plant viruses to produce vaccine proteins or peptides. It addresses the basis of mucosal immunity using plant-based oral vaccines, organelle targeting for vaccine production, and the role of glycosylation in plant-made mammalian proteins. It also considers vaccine production in entire crops or in large batch cell suspension cultures as well as the development of clinical trials. The book concludes with a risk analysis and discussion of future applications.

Catalog no. RU34317, ISBN: 978-0-7484-0440-7 November 2000, 252x177, 646 pp. Suggested Price: $409.95 / £261.00

Catalog no. K10263, ISBN: 978-1-4398-0474-2 November 2009, 6-1/8 x 9-1/4, 224 pp. Suggested Price: $99.95 / £63.99

Pharmacoeconomics From Theory to Practice Edited by

Renée J. G. Arnold Arnold Consultancy & Technology LLC, New York, USA Drug Discovery Series, 13

With emphasis on modeling, methodologies, data sources, and application to real-world dilemmas, this volume introduces the major concepts of pharmacoeconomics and cost-effectiveness analysis (CEA). As a running theme, the book explores the collaboration among the pharmaceutical industry, academia, and government in the development of the human papillomavirus vaccine to demonstrate the full range of ethical and moral issues, as well as public health and commercial concerns involved in decisions entailing CEA. The book teaches about the international use of pharmacoeconomics in drug regulation, drug approval, and pricing, and also provides examples of pharmacoeconomic models used to support these purposes. Catalog no. 84224, ISBN: 978-1-4200-8422-1 October 2009, 6-1/8 x 9-1/4, 264 pp. Suggested Price: $119.95 / £76.99

3-D Cell-Based Biosensors in Drug Discovery Programs

Cell Culture Technology for Pharmaceutical and Cell-Based Therapies Edited by

Sadettin Ozturk Centocor Inc., Nottingham, Pennsylvania, USA

Wei-Shou Hu University of Minnesota, Minneapolis, USA Series: Biotechnology and Bioprocessing, 30

Edited by two of the most distinguished pioneers in genetic manipulation and bioprocess technology, this bestselling reference presents a comprehensive overview of cell culture technology used in the pharmaceutical industry. Contributions from several leading researchers showcase the importance of gene discovery and genomic technology development in the production of biotechnology products, tissue engineering, and cell-based therapies. Offering detailed guidance, they cover the steps leading up to the creation of viable therapies, including host cell selection, cloning and gene amplification, bioreactor design and operation, protein purification, optimization, scale-up, and facility design. Catalog no. DK1481, ISBN: 978-0-8247-5334-4 August 2005, 7 x 10, 776 pp. Suggested Price: $195.95 / £127.00

Microtissue Engineering for High Throughput Screening

Chemicals from Microalgae

William S. Kisaalita

Zvi Cohen

University of Georgia, Athens, USA

This book is based upon cutting-edge research conducted in the author’s lab (Cellular Bioengineering), which during the past decade has developed a number of sophisticated techniques to facilitate use of 3D cell based assays or biosensors. This book uses data from peer-reviewed publications to conclusively justify use of 3D cell cultures in cell-based biosensors (assays) for (HTS). The majority of assays performed in accelerated drug discovery processes are biochemical in nature, but there is a growing demand for live cell-based assays. Unlike biochemical ones, cellular assays are functional approximations of in vivo biological conditions and can provide more biologically relevant information. Catalog no. 73494, ISBN: 978-1-4200-7349-2 June 2010, 6-1/8 x 9-1/4, 350 pp. Suggested Price: $129.95 / £82.00

Edited by

Ben-Gurion University of the Negev, Israel

The production of chemicals from microalgae is a significant area of biological research. This work seeks to cover the various aspects that relate to the use of microalgae as a source of chemicals. The chapters discuss the occurrence and physiological role of these chemicals and concentrates on the methods aimed at enhancing their content, as well as large-scale algal biomass production and down-stream processing. It describes the major algal chemicals of interest, namely pigments and lipids. Catalog no. TF2006, ISBN: 978-0-7484-0515-2 May 1999, 6-1/8 x 9-1/4, 419 pp. Suggested Price: $229.95 / £146.00

Advances in Chromatographic Techniques for Therapeutic Drug Monitoring Edited by

Handbook of Pharmaceutical Controlled Release Technology

Amitava Dasgupta

Edited by

University of Texas Health Sciences Center at Houston, USA

Donald L. Wise

For drugs with a narrow therapeutic index, therapeutic drug monitoring methods are essential for patient management. Although immunoassays are commercially available for many drugs and most laboratories use these assays for routine therapeutic monitoring, they have many limitations which hinder their efficacy. Providing practical guidelines for implementing chromatographic methods, this volume describes the theory and application of therapeutic drug monitoring in clinical laboratories. It addresses preanalytical variables, the pitfalls of immunoassays, tandem mass spectrometry, issues related to pain management and herbal supplements, and drug monitoring for a range of medications.

Reviewing the design, fabrication, methodology, administration, and classifications of various drug delivery systems, this bestselling Handbook of Pharmaceutical Controlled Release Technology provides exhaustive coverage on a huge range of systems and devices. It fully examines the cost, comfort, disease control, side effects, and patient compliance involved with the oral, transdermal, parenteral, and implantable delivery of drugs. Among a wealth of topics, it discusses controlled release systems; examines matrices, and membranecontrolled reservoir systems; evaluates polymers as drug delivery carriers; and describes peptide, protein, micro, and nanoparticulate release systems.

Catalog no. 67583, ISBN: 978-1-4200-6758-3 October 2009, 7 x 10, 475 pp. Suggested Price: $169.95 / £108.00

Catalog no. DK1638, ISBN: 978-0-8247-0369-1 August 2000, 7 x 10, 902 pp. Suggested Price: $279.95 / £178.00

Colloids in Drug Delivery Edited by

Monzer Fanun

Polymers in Drug Delivery Edited by

Ijeoma F. Uchegbu University of London, UK

Al-Quds University, East Jerusalem, Israel Series: Surfactant Science, 150

Andreas G. Schatzlein

With significant applications in drug delivery and formulation science, colloids offer the same advantages of typical materials used for release but can be tailored to specific bulk material properties such as release profiles. Colloidal systems have the potential to increase the shelf life and improve efficacy of a drug, thus reducing the required dosage concentrations and the frequency of administration. Featuring contributions from an international panel of scientists and researchers, this book presents the most recent findings on the application of colloidal properties in drug delivery systems, contributing to the understanding and improved design of novel and advanced drug delivery applications.

In recent years there has been an explosion in the use of polymers to solve various biomedical problems. Polymers play a crucial role in controlling drug release rate, enhancing drug solubility and uptake, and limiting drug degradation and toxicity. Polymers in Drug Delivery is a valuable review of all areas in which polymers are used in drug delivery, including hydrogels, soluble polymer drug conjugates, polymeric vesicles and micelles, microspheres, nanoparticles, polymeric in tissue engineering, and more. It is a readily accessible volume suitable for drug delivery scientists and as reading for advanced pharmaceutical students and others new to the field.

Catalog no. K10958, ISBN: 978-1-4398-1825-1 February 2010, 7 x 10, 736 pp. Suggested Price: $159.95 / £99.00

Catalog no. TF4008, ISBN: 978-0-8493-2533-5 May 2006, 7 x 10, 280 pp. Suggested Price: $164.95 / £105.00

Drug Device Combination Products Delivery Technologies and Applications

University of Glasgow, Scotland

Targeted Delivery of Small and Macromolecular Drugs Edited by

Ram I. Mahato

Edited by

University of Tennessee Health Science Center, Memphis, USA

A. Lewis

Ajit S. Narang

Biocompatibles, Surrey, UK

Bristol-Myers Squibb, Co., New Brunswick, New Jersey, USA

Drug delivery systems represent a vast area of research and development within biomaterials and medicine, and the demand for sophisticated drug delivery devices continues to drive novel product development. This book illustrates how effective drug delivery can be achieved by means other than oral tablets. Written by an international team of experts, this book provides a thorough analysis of the fundamentals, applications, and new technologies of drug-device combination products for use throughout the human body. Topics featured include background information, areas of application, and the development of drug device combination products.

Site-specific drug delivery and targeting has attracted much research interest from both academia and industry, but because of the wide array of challenges faced in the development of these systems, only a very few targeted therapies have made it to clinics. Bringing together key research, this volume summarizes current progress with a focus on the novel ideas that are being explored to overcome these challenges. This forward-looking volume includes an in-depth review of various aspects of these drug delivery approaches as well as a detailed discussion of a few case studies in each category.

Catalog no. N10136, ISBN: 978-1-4398-2479-5 January 2010, 6 x 9 Suggested Price: $244.99 / £155.00

Drug Delivery

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

Catalog no. 8772X, ISBN: 978-1-4200-8772-7 May 2010, 7 x 10, 632 pp. Suggested Price: $99.95 / £63.99

For more information and a complete list Anticancer Agents from Natural Products Edited by

Gordon M. Cragg and David J. Newman National Cancer Institute, Frederick, Maryland, USA

David G.I. Kingston Virginia Polytechnic Institute & State University, Blacksburg, USA

Drug Discovery & Development 64

Approaches to the Conformational Analysis of Biopharmaceuticals Roger L. Lundblad Lundblad Biotechnology, Chapel Hill, North Carolina, USA

Edited by leading scientists who have contributed enormously to natural product development and potential anticancer natural products, Anticancer Agents from Natural Products provides a historical, biochemical, and chemical rationale to the search for plant, marine, or microbial sources that may provide future templates for drug lead optimization and synthetic drug design. It provides an analysis of the research and development of some of the most effective anticancer agents available that are natural products or clearly derived from natural product leads. It is an ideal foundation for scientists engaged in developing new and improved drugs based on natural sources.

Conformational analysis is becoming more critical in the development of generic biopharmaceuticals. This book describes methods used to establish comparability between potentially identical products. It provides researchers with a critical description of studies drawn from the current literature. The text covers physical methods, such as differential scanning calorimetry, light scanning, and analytical ultracentrifugation, as well as chemical methods, including hydrogen-deuterium exchange and trace labeling. The author shows how these methods support comparability claims for generic biologicals and assure structural integrity of active pharmaceutical ingredients in final drug products.

Catalog no. 1863, ISBN: 978-0-8493-1863-4 June 2005, 7 x 10, 600 pp. Suggested Price: $195.95 / £127.00

Catalog no. K10401, ISBN: 978-1-4398-0780-4 December 2009, 6-1/8 x 9-1/4, 354 pp. Suggested Price: $149.95 / £95.00

Antisense Drug Technology Principles, Strategies, and Applications, Second Edition

Chemical Information Mining Facilitating Literature-Based Discovery

Edited by

Stanley T. Crooke

Debra L. Banville

ISIS Pharmaceuticals Inc., Carlsbad, California, USA

AstraZeneca Pharmaceuticals, Wilmington, Delaware, USA

Extensively revised and updated, this second edition incorporates lessons learned from first generation clinical trials, evaluates the technology as a whole, and offers new directions and avenues of research and development. The book explains mechanisms of action, pharmacokinetics of delivery, and the therapeutic potential of antisense drugs, ologonucleotides, hybridization-based drugs, duplex RNA, and more. Leading researchers discuss improvements to second generation drugs and consider the potential of antisense drugs for the alleviation of cardiovascular diseases, metabolic diseases, inflammatory diseases, cancer, neurological disorders, and immune modulation.

This book focuses on information extraction issues, highlights available solutions, and underscores the value of these solutions to academic and commercial scientists. After introducing the drivers behind chemical text mining, the book discusses chemical semantics. The contributors describe the tools that identify and convert chemical names and images to structure-searchable information. They also explain natural language processing, name entity recognition concepts, and semantic web technologies. Following a section on current trends in the field, the text looks at where information mining approaches fit into research needs within the life sciences.

Catalog no. 8796, ISBN: 978-0-8493-8796-8 July 2007, 7 x 10, 848 pp. Suggested Price: $239.95 / £152.00

Catalog no. 76493, ISBN: 978-1-4200-7649-3 December 2008, 6-1/8 x 9-1/4, 208 pp. Suggested Price: $99.95 / £63.99

Applying Genomic and Proteomic Microarray Technology in Drug Discovery

Design and Use of Relational Databases in Chemistry

Robert S. Matson

TJ O’Donnell

Orange, California, USA

President, gNova Inc., San Diego, California, USA

Applying Genomic and Proteomic Microarray Technology in Drug Discovery evaluates current research using microarray technology in genomics and proteomics, providing practical tips on its employment in drug discovery and development. The book details the commercial landscape, critically assessing those studies that have helped define applications in genomics and proteomics, explains gene expression microarray applications, and examines the utility of the protein microarray. He covers alternative substrates, the preparation of various surface chemistries, and looks at their suitability for immobilizing nucleic acids and proteins. He also explains the mechanics, including printer and pin performance; and supplies printing protocols.

Through many examples of good database design, this book shows that relational databases are the best way to store, search, and act on chemical information. Introducing the concepts of RDMS and SQL, the author describes how relational data tables and new data types help store and use chemical information, how molecular structures can become a new data type in a database, and how client programs can effectively use relational databases. He also explains how a fully functioning chemical relational database system can be built. A supplementary website offers an implementation of every function from the book, a database of structures and data, and examples used in the book.

Catalog no. 1469, ISBN: 978-0-8493-1469-8 December 2004, 6-1/8 x 9-1/4, 256 pp. Suggested Price: $185.95 / £121.00

Catalog no. 64428, ISBN: 978-1-4200-6442-1 December 2008, 6-1/8 x 9-1/4, 224 pp. Suggested Price: $129.95 / £82.00

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m High-Throughput Analysis in the Pharmaceutical Industry Edited by

Edited by

Perry G. Wang

John W. Blunt and Murray H.G. Munro

Teleflex, Wyomissing, Pennsylvania, USA Series: Critical Reviews in Combinatorial Chemistry, 4

University of Canterbury, Christchurch, New Zealand

Focusing for the first time on more than 25,000 marine-specific natural products, Dictionary of Marine Natural Products with CD-ROM indexes each product by chemical name, organism type, and compound type. Following a similar format to the Chapman & Hall Chemical Database, this comprehensive volume is mirrored on an accompanying CD-ROM that is fully text and structure-searchable. Each entry includes biological source, chemical structure, physical properties, biological activity, and literature references. This new tool offers immediate access to information essential to the development of novel pharmaceuticals, pesticides, and marine anti-fouling agents derived from unique molecular structures of marine natural products. Catalog no. 8216, ISBN: 978-0-8493-8216-1 September 2007, 8-1/2 x 11, 2536 pp. Suggested Price: $599.00 / £382.00

Gene Profiles in Drug Design

High throughput analysis plays a critical role in the pharmaceutical industry. The ever-shortening timelines and high costs of drug discovery and development have brought about the need for high throughput approaches to methods that are used in the industry. Written and edited by well-known contributors who remain active in this line of research, this book systematically describes high throughput analysis for the pharmaceutical industry, including advanced instrumentation and automated sample preparation. The text discusses various techniques, including HPLC, MALDI-MS, and LC-MS/MS methods, with an emphasis on the later stage of drug development, including pharmacokinetics. Catalog no. 5953X, ISBN: 978-1-4200-5953-3 August 2008, 7 x 10, 432 pp. Suggested Price: $159.95 / £99.00

High-Throughput Lead Optimization in Drug Discovery Edited by

Edited by

Tushar Kshirsagar

Brett A. Lidbury and Suresh Mahalingam

3M Pharmaceuticals, St. Paul, Minnesota, USA Series: Critical Reviews in Combinatorial Chemistry, 3

University of Canberra, Australia

Featuring contributions from leading researchers across a number of fields, this volume explores the processes and technologies that yield gene profile-based drugs. Each chapter focuses on one component or a single step in the process of translating abstract gene profiles into tangible new drugs. The first part of the text compares the advantages and pitfalls of various methods used to generate gene profiles. The next section discusses modern uses of gene profiles in drug design, including lead identification. The book concludes with a look at emerging technologies that use gene profiles to design high-specificity drugs. Catalog no. DK6021, ISBN: 978-0-8493-3733-8 July 2008, 6-1/8 x 9-1/4, 160 pp. Suggested Price: $139.95 / £89.00

Handbook of Assay Development in Drug Discovery Edited by

A single source on parallel synthesis for lead optimization, this book features real-world examples and contributions from well-known scientists. It explores the shift to conducting parallel lead optimization in-house while outsourcing most of the screening libraries synthesis. With more than 15 case studies that encompass a range of biological targets for application in different therapeutic areas, the text contains examples of solid and solution-phase techniques for the synthesis of directed libraries. The chapter authors explain the design principles they used to direct the choice of templates and diversity elements. They explore how this technology, when applied to library design, can speed up drug discovery. Catalog no. 7268, ISBN: 978-0-8493-7268-1 March 2008, 7 x 10, 256 pp. Suggested Price: $149.95 / £95.00

Human Error in Medicine

Lisa K. Minor

Second Edition

Johnson & Johnson Pharmaceutical Research & Development, LLC, Springhouse, Pennsylvania, USA Drug Discovery Series, 5

Marilyn Sue Bogner Institute for the Study of Human Error, Bethesda, Maryland, USA Series: Human Error and Safety

The Handbook of Assay Development in Drug Discovery describes all the tools available for performing various assay techniques. Featuring troubleshooting advice for common problems from experienced assay developers, the vendor community, and scientists in the pharmaceutical industry, the book presents descriptions of methods, laboratory guidelines, and protocols used to perform such methods, specific examples of each assay system, and troubleshooting tools. Designed as a guide to running an assay from start to finish, this is an ideal bench top companion for scientists involved in drug discovery screening, lead profiling, therapeutic target evaluation, and assay development and implementation.

While providers are typically blamed, empirical evidence shows that medical errors are due most often to the convergence of multiple contributing factors. This new edition of Human Error in Medicine presents an expanded consideration of the topic that emphasizes lessons learned not just in hospitals, but also in home and self-care – important because of the increasing prevalence of chronic illnesses. Bringing together diverse experts, the book covers a wide range of topics, including errors in the use of medical equipment, errors from fatigued decision making, latent surgical errors, medical error in the legal system, and error reduction through improved technology and facility design.

Catalog no. DK3264, ISBN: 978-1-57444-471-1 January 2006, 7 x 10, 488 pp. Suggested Price: $154.95 / £98.00

Catalog no. ER522X, ISBN: 978-0-8058-4522-8 June 2010, 6-1/8 x 9-1/4, 368 pp., Soft Cover Suggested Price: $49.95 / £31.99

Drug Discovery & Development

Dictionary of Marine Natural Products with CD-ROM

For more information and a complete list Index Nominum International Drug Directory, Nineteenth Edition Edited by

Swiss Pharmaceutical Society, Germany

Edited by

Taosheng Chen Memphis, Tennessee, USA Series: Critical Reviews in Combinatorial Chemistry, 5

Drug Discovery & Development

After 50 years, this authoritative index continues to reign as the standard international pharmaceutical reference on medications, proprietary names, synonyms, chemical structures, and therapeutic classes of substances. This 19th edition offers improved search functionality and includes 70,000 proprietary names (19,000 more than the previous edition) from more than 12,000 manufacturers representing 171 countries. It also contains an updated and edited collection of active substances and derivatives (4,000 total) with international non-proprietary names (INN) and 12,000 synonyms. An accompanying CD provides more than 12,000 addresses and links to pharmaceutical manufacturers worldwide.

Few scientists have access to the multidisciplinary experience needed for successful assay development and high-throughput screening (HTS) in drug discovery. Designed to give researchers a boost, this text integrates the experience of diverse experts who offer fundamental practical guidance across numerous situations. It introduces emerging technology that allows scientists to identify and capture relevant information. It instructs in how to initiate, validate, optimize, and manage a bioassay intended to screen large collections of compounds. It also identifies critical targets of relevance in drug discovery and treats each individually in terms of the parameters needed for successful assay development.

Catalog no. V5042, ISBN: 978-3-8047-5042-5 May 2008, 9 x 12, 1982 pp. Suggested Price: $395.00

Catalog no. 70509, ISBN: 978-14-2007-050-7 December 2009, 7 x 10, 278 pp. Suggested Price: $159.95 / £99.00

Not available outside North and South America

Methods in Microarray Normalization Edited by

Process Chemistry in the Pharmaceutical Industry

Phillip Stafford

Edited by

Arizona State University, Tempe, USA Drug Discovery Series

A Practical Guide to Assay Development and HighThroughput Screening in Drug Discovery

This organized text compiles, for the first time, the most useful normalization methods developed for interpreting microarray data. Experts examine the mathematical processes that are important in normalizing data and avoiding inherent systematic biases. They also review modern software, including discussions on key algorithms, comparative data, and download locations. The book contains the latest microarray innovations from companies such as Agilent, Affymetrix, and GeneGo as well as new, readily adaptable normalization methods for expression and CGH arrays. It also lists of open-source molecular profiling normalization algorithms available and where to access them. Catalog no. 52780, ISBN: 978-1-4200-5278-7 January 2008, 6-1/8 x 9-1/4, 304 pp. Suggested Price: $79.95 / £49.99

Kumar G. Gadamasetti Delphian Pharmaceuticals, Belmont, California, USA

An ideal guide for scientists entering pharmaceutical discovery and development, this reference also clarifies the roles of various specialties in drug development. Featuring contributions from nearly 50 renowned researchers and more than 1000 references, tables, and illustrations, it offers a solid grounding in synthetic as well as physical organic chemistry. This volume highlights strategies for aggressive drug development programs, green synthesis processes, and other trends in the industry. It illustrates the impact of non-traditional small molecules as a therapeutic agent, including 12 case studies on agents such as inhibitors and antangonists. Catalog no. DK2505, ISBN: 978-0-8247-1981-4 May 1999, 7 x 10, 500 pp. Suggested Price: $229.95 / £146.00

Process Chemistry in the Pharmaceutical Industry Pharmaceutical Chemical Analysis Methods for Identification and Limit Tests Ole Pedersen Quality Control GEA Ltd., Hvidovre, Denmark

Pharmaceutical Chemical Analysis: Methods for Limit Tests and Identifications covers the identification of ions and functional groups tests and limit tests respectively. It discusses subjects relevant to all the pharmacopoeial identification/limit test and then goes on to describe the individual tests in chapters organized and named as they appear in the European Pharmacopoeia. Each chapter begins with a short discussion on the purpose and rationale of the tests, followed by a review of the physical and chemical characteristics of the target ion or compound. The author describes the chemical background and logic of the individual procedural steps of the test with formulas and reaction and provides tips on the strengths and weaknesses of these techniques in terms of specificity, ruggedness, and potential procedural pitfalls. Catalog no. PH1978, ISBN: 978-0-8493-1978-5 January 2006, X, 176 pp. Suggested Price: $195.95 / £127.00

Volume 2 Challenges in an Ever Changing Climate Edited by

Kumar Gadamasetti Delphian Pharmaceuticals, Belmont, California, USA

Tamim Braish Pfizer Global Research & Development, Groton, Connecticut, USA

Defying the misconception of process chemistry as mere scale-up work, this volume explores modern process research and development methods applied to synthesis, clinical trials, and commercial drug candidates. It discusses approaches to synthetic processes, examines safety methods and design experiments, and suggests realistic solutions to problems encountered in manufacturing and process development. Topics include synthesis methods, instrumentation, automation, quality control, cost considerations, regulatory issues, outsourcing, green practices, and future trends. Case studies demonstrate strategies for aggressive drug development programs. Catalog no. 9051, ISBN: 978-0-8493-9051-7 December 2007, 7 x 10, 520 pp. Suggested Price: $259.95 / £165.00

Quantitative Drug Design A Critical Introduction, Second Edition Yvonne C. Martin

Chemistry and Molecular Aspects of Drug Design and Action Edited by

E. A. Rekka and P. N. Kourounakis

Abbotts Lab, Waukegan, Illinois, USA

Aristotelian University of Thessaloniki, Greece

Applying quantitative structure-activity relationship (QSAR) techniques at a state-of-the-art level, this book describes how to transform ligand structureactivity relationships into models that predict the potency or activity/inactivity of new molecules. This edition contains a new chapter on methods that identify the 3D conformations to use for 3D QSAR and offers additional discussions on statistical topics, such as partial least squares and kNN potency prediction. Along with re-analyzing old data using newer methods, the expanded case studies explore molecular design based on 3D modeling and include comparisons of ligand- and structure-based models of biological potency.

Drawn from the work of world-renowned pharmacochemistry scientists, this book explores research that defines the emergence of rational drug design. Offering insight from their own specialized subjects, these pioneers highlight the variety of approaches being employed in this field, including those that start by considering either molecular mechanisms of drug action, or the metabolizing enzyme action occurring in the structure of a drug molecule. Another approach they explore is one that starts from the pathobiochemistry and pathophysiology of target diseases. Furthermore, the book also considers drug development that makes use of already developed compounds stored in data banks.

Catalog no. 70991, ISBN: 978-1-4200-7099-6 January 2010, 6-1/8 x 9-1/4, 392 pp. Suggested Price: $129.95 / £82.00

Catalog no. 9006, ISBN: 978-0-8493-9006-7 April 2008, 6-1/8 x 9-1/4, 384 pp. Suggested Price: $179.95 / £114.00

Textbook

Textbook of Drug Design and Discovery Fourth Edition Edited by

Povl Krogsgaard-Larsen, Ulf Madsen, and Kristian Stromgaard The Faculty of Pharmaceutical Sciences, University of Copenhagen

Drug Synergism and Dose-Effect Data Analysis Ronald J. Tallarida Temple University, Philadelphia, Pennsylvania, USA

This bestselling textbook describes how medicinal chemists draw on a variety of fields and the strategies they employ to advance promising molecules into clinical use. The first part of the book covers general aspects, methods, and principles for drug design and discovery, and the second part covers specific targets and diseases. Each chapter includes references for further study. Most chapters also include some background and history needed to provide context and conclusions that summarize the important points. New topics in this edition include biostructure- and ligandbased drug design, natural products, imaging, neurotransmitter transporters, opioid and cannabinoid receptors, hypnotics, neglected diseases, and antibiotics.

Not since this author’s bestselling Manual of Pharmacologic Calculation has there been an available reference for drug data analysis. Incorporating the most relevant parts of that work, Drug Synergism and Dose-Effect Data Analysis focuses on drug combinations and all the quantitative analyses needed to analyze drug combination dose-effect data and to design experiments with two or more compounds. The book contains the statistical methods, the theory, and the computation algorithms needed to analyze single and combination drug data. Numerous examples accompany a presentation that illustrates the calculations and experimental design considerations for modern drug analysis.

Catalog no. 63227, ISBN: 978-1-4200-6322-6 October 2009, 7 x 10, 476 pp. Suggested Price: $79.95 / £49.99

Catalog no. C0457, ISBN: 978-1-58488-045-5 July 2000, 6-1/8 x 9-1/4, 264 pp. Suggested Price: $79.95 / £49.99

Also Available in Soft Cover

Water-Insoluble Drug Formulation Second Edition Edited by

Rong Liu AustarPharma, Edison, New Jersey, USA

Handbook of Microbiological Quality Control in Pharmaceuticals and Medical Devices Edited by

Rosamund M. Baird, Norman A. Hodges, and Stephen P. Denyer Series: Pharmaceutical Science Series

Scientists have attributed more than 41 percent of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility The most comprehensive resource on the topic, this second edition brings together a distinguished team of experts to provide step-by-step guidance and scientific background on drug and water properties. Twenty-three chapters systematically describe solubility properties and their impact on formulation, from theory to industrial practice. With detailed discussion on how they contribute to solubilization and dissolution, the text also features three additional chapters on water-insoluble drugs, exploring regulatory aspects, pharmacokinetic behaviors, and formulation strategies.

The Handbook of Microbiological Quality Control provides a unique distillation of material by providing a wealth of microbiological information not only on the practical issues facing the company microbiologist, but also the underlying principles of microbiological quality assurance. The book provides guidance on safe microbiological practices, including laboratory design and sampling techniques, and considers the design storage, use and quality control of microbiological culture in depth. All the chapters have been written by leading experts in this field, making the Handbook the essential reference source for the professional microbiologist.

Catalog no. 9644, ISBN: 978-0-8493-9644-1 January 2008, 7 x 10, 688 pp. Suggested Price: $299.95 / £191.00

Catalog no. TF2047, ISBN: 978-0-7484-0614-2 August 2000, 7 x 10, 280 pp. Suggested Price: $179.95 / £97.00

Drug Discovery & Development / Pharmaceutical Science

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

For more information and a complete list Bioactive Natural Products Detection, Isolation, and Structural Determination, Second Edition

Handbook of Solubility Data for Pharmaceuticals

Pharmaceutical Science / Pharmacology 68

Abolghasem Jouyban Tabriz University, Iran

This time-saving handbook presents a comprehensive database of solubility for pharmaceuticals in organic solvents and binary solvent mixtures. It includes a summary of numerous numerical methods to predict the solubility in mono and mixed solvents and provides the model constants of the Jouyban–Acree model for each solute in binary solvents at various temperatures to predict unmeasured solubilities. The book covers pharmaceutical cosolvents, other organic solvents, and the solubilities of amino acids. User-friendly software to predict the solubility of drugs in mono and mixed solvents is available on the author’s website. Catalog no. K10268, ISBN: 978-1-4398-0485-8 August 2009, 7 x 10, 552 pp. Suggested Price: $249.95 / £159.00

Edited by

Steven M. Colegate CSIRO/Plant Toxins Unit, Division of Animal Health, Geelong, Australia

Russell J. Molyneux Western Regional Research Center, Albany, California, USA

Following the successful format of its predecessor, this second edition presents applications of techniques for the detection, isolation, and structural determination of bioactive natural products. This edition features added case studies and illustrations that demonstrate practical applications of techniques covered in the book. The text includes updates on bioactive chemical extraction, and NMR-based structure determination, along with contributions on liquid chromatography linked with mass spectrometry and NMR spectroscopy, dereplication approaches, assessment of source material for bioactive natural products, and novel bioassay development. Catalog no. 7258, ISBN: 978-0-8493-7258-2 December 2007, 7 x 10, 624 pp. Suggested Price: $209.95 / £134.00

Polysaccharides Structural Diversity and Functional Versatility, Second Edition

Bioactive Peptides

Edited by

Severian Dumitriu

John Howl and Sarah Jones

University of Sherbrooke, Canada

University of Wolverhampton, United Kingdom

Completely revised and expanded to reflect advancements in the field, Polysaccharides: Structural Diversity and Functional Versatility, Second Edition outlines fundamental concepts in the structure, function, chemistry, and stability of polysaccharides and reveals analytical techniques and applications that impact the cosmetic, medicinal, chemical, and biochemical industries. The authoritative book discusses polysaccharides utilized in medical applications, such as polysaccharide-based hydrogels, polysialic acids, proteoglycans, glycolipids, and anticoagulant polysaccharides; along with renewable resources for the production of various industrial chemicals and engineering plastics polysaccharides.

Answering a long-standing need in the pharmaceutical and biotechnology fields, this definitive reference focuses on the biology, pharmacology, and therapeutic applications of endogenous peptide mediators and their analogues. This book takes peptide science beyond chemical synthesis strategies and into the realms of peptide biology and therapeutics. It presents the overall contribution peptide science has made to molecular, cellular, and whole organism biology, while discussing future targets and therapeutic applications. With the mounting worldwide interest in the therapeutic potential of peptides, this is an indispensable work for researchers.

Catalog no. DK1167, ISBN: 978-0-8247-5480-8 November 2004, 8-1/2 x 11, 1224 pp. Suggested Price: $309.95 / £197.00

Catalog no. 61143, ISBN: 978-1-4200-6114-7 April 2009, 7 x 10, 503 pp. Suggested Price: $179.95 / £109.00

Quality Assurance and Quality Control in the Analytical Chemical Laboratory

Dictionary of Alkaloids

A Practical Approach

Second Edition with CD-ROM

Piotr Konieczka and Jacek Namie´snik

Edited by

Gdansk University of Technology, Poland Series: Analytical Chemistry, 6

John Buckingham, Keith H. Baggaley, Andrew D. Roberts, and László F. Szabo

Using an approach grounded in hands-on experience, this book provides a strong foundation of the concepts of practical QA/QC. It begins with the theory behind quality control systems and then moves on to discuss examples of tools such as validation parameter measurements. It also examines the use of statistical tests, describes the process of counting the margin of error, and discusses estimating uncertainty. The authors draw on their experience in traceability, statistics, proficiency tests, and method validation to craft a resource that provides practical guidance for each step of the quality assurance process.

While some of the most commonly investigated and most notorious chemicals in the world are alkaloids, many modern medicines are also based on alkaloid structures. Chemists continue to explore new synthetic routes and alkaloid derivatives in search of drug candidates for fighting disease. This comprehensive dictionary documents and categorizes all known alkaloids. Drawn from the authoritative Dictionary of Natural Products, this edition doubles the amount of entries to present concise chemical, structural, and physical data on more than 20,000 alkaloids. Each entry also includes biological sources and activity, chemical structure, physical properties, and literature references. A fully searchable CDROM version of the database also accompanies this volume.

Catalog no. 82701, ISBN: 978-1-4200-8270-8 February 2009, 6-1/8 x 9-1/4, 232 pp. Suggested Price: $129.95 / £78.99

Catalog no. 77694, ISBN: 978-1-4200-7769-8 December 2009, 8-1/2 x 11, 2264 pp. Suggested Price: $695.00 / £442.00

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

Second Edition Kim D. Rainsford Hallam University, Sheffield, UK

Already regarded as a standard reference for anyone who needs to know about the actions and uses of anti-inflammatory and analgesic drugs, this second edition provides even more. It updates information on the medicinal chemistry and the pharmaceutics of ibuprofen and its pharmacokinetics in both humans and animals. It includes molecular pharmacology and toxicological studies, and discusses the safety and efficacy of non-prescription ibuprofen, including its side effects. The text also addresses the therapeutic role of ibuprofen in rheumatic conditions, Alzheimer’s disease, and cancer. Catalog no. 46365, ISBN: 978-1-4200-4636-6 June 2010, 7 x 10, 896 pp. Suggested Price: $199.95 / £127.00

Textbook

Textbook of Receptor Pharmacology Third Edition Edited by

John C. Foreman and Alasdair J. Gibb University College London, UK

Torben Johansen University of Southern Denmark

Providing an introduction to the study of drug receptors, the Textbook of Receptor Pharmacology discusses quantitative descriptions of functional studies with agonists and antagonists; quantitative descriptions of ligands binding to receptors; the molecular structures of drug receptors; and the elements that transport the signal from the activated receptor to the intracellular compartment. This third edition features results from recent research on how the structure of receptors determines the interaction between the receptor and the signal transducer. This edition also offers new information on ligand binding receptor studies that use newly developed techniques. Catalog no. 52543, ISBN: 978-1-4200-5254-1 June 2010, 7 x 10, 320 pp. Suggested Price: $109.95 / £69.99

Textbook

Basic Pharmacology Understanding Drug Actions and Reactions Maria A. Hernandez and Appu Rathinavelu Nova Southeastern University, Fort Lauderdale, Florida, USA Plant Engineering Series, 20

Written as an introductory pharmacology text, Basic Pharmacology: Understanding Drug Actions and Reactions provides the in-depth discussion of the chemical and molecular pharmacology fundamentals that pharmacy students require to move on to more advanced study. Employing the extensive use of model drug structures, the authors effectively explain chemical and molecular pharmacology principles. The book covers the principles of chemistry and biology necessary to understand drug action at the cellular level. It emphasizes the chemical and physical properties of drugs, drug absorption and distribution, drug interactions with cellular receptors, and drug metabolism and interactions. Catalog no. TX605, ISBN: 978-1-58716-160-5 February 2006, 6-1/8 x 9-1/4, 392 pp. Suggested Price: $78.95 / £49.99

Drug Delivery and Targetting For Pharmacists and Pharmaceutical Scientists Edited by

Anya M. Hilary Saint Louis University, Madrid, Spain

Andrew W. Lloyd University of Brighton, UK

James Swarbrick PharmaceuTech, Inc, Pinehurst, North Carolina, USA

An accessible and easy-to-read text, this is the first book to provide a comprehensive introduction to the principles of advanced drug delivery and targeting, their applications, and potential developments, making it indispensable for pharmaceutical students, scientists, and researchers. It covers how to optimize therapeutic efficacy; drug absorption, unwanted distribution and premature inactivation / elimination; attempts to minimize toxicity or alter immunogenicity; achieving rate-controlled drug release and effective drug targeting; routes of delivery; and technologies such as biosensors, microchips, stimuli-sensitive hydrogels, and plasmid-based gene therapy. Catalog no. TF1359, ISBN: 978-0-415-27198-1 September 2001, 7 x 10, 496 pp., Soft Cover Suggested Price: $88.95 / £56.99

Textbook Textbook

Basic Pharmacokinetics

Pharmacology / Pharmacy

Ibuprofen: A Critical Bibliographic Review

Essentials of Human Physiology for Pharmacy Second Edition

Mohsen A. Hedaya

Laurie Kelly McCorry

Tanta University, Egypt Plant Engineering Series

Bunker Hill Community College, Boston, Massachusetts, USA Plant Engineering Series, 19

An accessible introduction to foundational concepts, Basic Pharmacokinetics has been carefully designed for students and others who have never studied the subject before. Exploring the use of mathematical models to predict the response of individual patients to drugs, this book features a CD-ROM that complements the material presented in the text. The CD includes computer-based presentations that use graphics and simulations to allow readers to visualize how a change in one or more pharmacokinetic parameter is reflected in the drug profile of the body. Using a self-instructional format, this text serves as a useful reference covering such topics as drug absorption and therapeutic drug monitoring.

Designed as a resource for pharmacy and health science students, Essentials of Human Physiology for Pharmacy, Second Edition emphasizes the connection and relevance of physiology to pharmacy practice. Every chapter is updated and expanded and added chapters are included on the immune system and the reproductive system. Revised pharmacy applications demonstrate basic principles in physiology and their use in pharmacy practice. Each chapter also offers medical terminology, including definitions, associated terms, and pronunciations, as well as relevant drugs used to treat the disorders discussed, explaining their classifications and therapeutic actions.

Catalog no. 46713, ISBN: 978-1-4200-4671-7 April 2007, 6-1/8 x 9-1/4, 328 pp. Suggested Price: $83.95 / £53.99

Catalog no. 43900, ISBN: 978-1-4200-4390-7 July 2008, 6-1/8 x 9-1/4, 520 pp. Suggested Price: $79.95 / £49.99

For more information and a complete list Textbook

Essentials of Law and Ethics for Pharmacy Technicians Second Edition Kenneth M. Strandberg North Dakota State University, Fargo, USA Plant Engineering Series, 12

Dipak K. Dey University of Connecticut, Storrs, USA

Samiran Ghosh Indiana University-Purdue University, Indianapolis, USA

Bani K. Mallick Texas A&M University, College Station, USA Chapman & Hall/CRC Biostatistics Series, 34

Pharmacy / Bioinformatics

This updated edition of Essentials of Law and Ethics for Pharmacy Technicians clearly explains those laws and regulations relevant to technicians and also examines the ethical issues involved. Fully revised to cover recent developments, it presents an overview of the U.S. legal system, reviews the development of current laws, and describes those laws affecting practice today. It incorporates an added chapter on the Health Information Portability and Accountability Act, the Dietary Supplement Health and Education Act, and the new FDA regulation on controlling pseudoephedrine sales. State issues are addressed in the extensive appendices.

One of the most comprehensive published references on this topic to date, this volume fills the gap in the vast but scattered literature on Bayesian bioinformatics and biostatistics. It presents the perspectives of Bayesian experts on important developments in bioinformatics and biostatistics from two unique standpoints. The book first looks at how to conceptualize, perform, and criticize traditional bioinformatics and biostatistics from a Bayesian perspective. Secondly, it examines how to use modern computational methods to summarize inferences using simulation. The book also explores emerging research topics.

Catalog no. 45563, ISBN: 978-1-4200-4556-7 April 2007, 6-1/8 x 9-1/4, 208 pp., Soft Cover Suggested Price: $49.95 / £31.99

Catalog no. C7017, ISBN: 978-1-4200-7017-0 March 2010, 6-1/8 x 9-1/4, 536 pp. Suggested Price: $89.95 / £57.99

Managing Pharmacy Practice

Bioinformatics Basics

Principles, Strategies, and Systems

Applications in Biological Science and Medicine, Second Edition

Edited by

Andrew M. Peterson Philadelphia College of Pharmacy, Pennsylvania, USA

Bayesian Modeling in Bioinformatics

Highlighting the growing impact of technology throughout pharmacy and healthcare, this text underlines the challenges of this rapidly evolving profession and explores strategies for success. Touching on basic management theory and thoroughly discussing systems theory, the text supplies the groundwork for analyzing managerial systems. This systems approach allows the reader to understand the contextual relationships between seemingly disparate concepts. With contributions from leaders in fields as diverse as pharmacy, human resources, education, and management, the book presents a broad overview of the complexities and intricacies inherent in managing systems in pharmacy. Catalog no. 1446, ISBN: 978-0-8493-1446-9 March 2004, 6-1/2 x 9-1/2, 536 pp. Suggested Price: $93.95 / £59.99

Textbook

Algorithms in Bioinformatics A Practical Introduction

Lukas K. Buehler Southwestern College & University of California, San Diego, USA

Hooman H. Rashidi Yale School of Medicine, New Haven, Connecticut, USA

Completely revised, Bioinformatics Basics: Applications in Biological Science and Medicine, Second Edition continues to be a useful tool for researchers who need to easily access and use databases to gather information on genes, proteins, and diseases. This bestseller covers modern approaches to data analysis using databases around the world. It identifies computing techniques that help readers manage the massive flow of information. The structure of this edition follows that of the first, and its content reflects the growth in information. Added sections cover developments in genome projects, microarrays, proteomics, genome mapping, and more. Catalog no. 1283, ISBN: 978-0-8493-1283-0 June 2005, 6-1/8 x 9-1/4, 360 pp. Suggested Price: $104.95 / £66.99

Bioinformatics High Performance Parallel Computer Architectures

Wing-Kin Sung

Edited by

National University of Singapore Series: Chapman & Hall/CRC Mathematical & Computational Biology, 29

Bertil Schmidt Nanyang Technological University, Singapore Series: Embedded Multi-Core Systems

This classroom-tested text provides an in-depth introduction to the algorithmic techniques applied in bioinformatics. For each topic, the author clearly details the biological motivation, precisely defines the corresponding computational problems, and includes detailed examples to illustrate each algorithm. The text covers basic molecular biology concepts, sequence similarity, the suffix tree, sequence databases, sequence and genome alignment, the phylogenetic tree, genome rearrangement, motif finding, the secondary structure of RNA, peptide sequencing, and population genetics. Supplementary material is provided on the author’s website and a solutions manual is available for qualifying instructors.

Written by internationally recognized experts, this book introduces emerging parallel architectures, their corresponding programming paradigms, and their bioinformatics applications. After providing two introductory chapters to supply necessary background on sequential bioinformatics algorithms and parallel architectures such as multi-cores, Cell B.E., GPUs, and FPGAs, it then presents parallelization strategies and performance evaluations for a number of state-ofthe-art bioinformatics algorithms and tools. Topics include pairwise sequence alignment, multiple sequence alignment, BLAST, motif finding, pattern matching, sequence assembly, hidden Markov models, molecular dynamics, and evolutionary tree reconstruction.

Catalog no. C7033, ISBN: 978-1-4200-7033-0 December 2009, 6-1/8 x 9-1/4, 407 pp. Suggested Price: $79.95 / £39.99

Catalog no. K10768, ISBN: 978-1-4398-1488-8 June 2010, 6-1/8 x 9-1/4, 400 pp. Suggested Price: $129.95 / £82.00

Bioinformatics A Practical Approach

Cancer Systems Biology

Edited by

Shui Qing Ye

Edwin Wang

University of Missouri, Columbia, USA Series: Chapman & Hall/CRC Mathematical & Computational Biology, 16

National Research Council of Canada, Montreal Series: Chapman & Hall/CRC Mathematical & Computational Biology, 32

This practical book provides an overview of modern bioinformatics applications. It first focuses on genome analysis, common DNA analysis tools, phylogenetics analysis, and SNP and haplotype analysis. After chapters on microarray, SAGE, regulation of gene expression, miRNA, and siRNA, the book presents widely applied programs and tools in proteome analysis, protein sequences, protein functions, and functional annotation of proteins in murine models. With more than 250 figures to complement the text, the book also introduces the programming languages used in biology, website and database design, and the interchange of data between Microsoft Excel and Access.

The unprecedented amount of data produced with high-throughput experimentation forces biologists to employ mathematical representation and computation to glean meaningful information in systems-level biology. Applying this approach to the underlying molecular mechanisms of tumorigenesis, cancer research is enjoying a series of new discoveries and biological insights. Unique in its dualistic approach, this book introduces the concepts and theories of systems biology and the applications of systems biology in cancer research. It presents basic cancer biology and cutting-edge topics of cancer research for computational biologists alongside systems biology analysis tools for experimental biologists.

Catalog no. C8105, ISBN: 978-1-58488-810-9 August 2007, 6-1/8 x 9-1/4, 648 pp. Suggested Price: $83.95 / £53.99

Catalog no. K10596, ISBN: 978-1-4398-1185-6 March 2010, 7 x 10, 360 pp. Suggested Price: $89.95 / £57.99

Textbook

Tel-Aviv University, Israel

Combinatorial Pattern Matching Algorithms in Computational Biology Using Perl and R

Ron Unger

Gabriel Valiente

Biological Computation Ehud Lamm Bar-Ilan University, Ramat-Gan, Israel Series: Chapman & Hall/CRC Mathematical & Computational Biology

Technical University of Catalonia, Barcelona, Spain Series: Chapman & Hall/CRC Mathematical & Computational Biology, 22

Created for advanced undergraduates in computer science programs, Biological Computation covers major themes of bio-inspired computing, including cellular automata, molecular computation, genetic algorithms, and neural networks. Providing theoretical and coding exercises, this self-contained text requires no previous knowledge of biology. The book provides valuable insight to researchers and students from biomedical backgrounds looking to gain the computational skills needed to enter the fields of systems biology, biological modeling, and simulations.

Emphasizing the search for patterns within and between biological sequences, trees, and graphs, this book shows how combinatorial pattern matching algorithms can solve computational biology problems that arise in the analysis of genomic, transcriptomic, proteomic, metabolomic, and interactomic data. It provides an intuitive presentation of the algorithms, followed by a detailed exposition in pseudo-code. The author offers alternative implementations of the algorithms in Perl and R to enable the testing of algorithms and the building of projects based on the code. He also includes the Perl and R source code for all the algorithms on his website.

Catalog no. C7959, ISBN: 978-1-4200-8795-6 May 2010, 6-1/8 x 9-1/4, 306 pp. Suggested Price: $79.95 / £49.99

Biological Sequence Analysis Using the SeqAn C++ Library Andreas Gogol-Döring

Catalog no. C6973, ISBN: 978-1-4200-6973-0 April 2009, 6-1/8 x 9-1/4, 368 pp. Suggested Price: $89.95 / £54.99

Textbook

Data Analysis Tools for DNA Microarrays Using R

Institut fur Informatik, Berlin, Germany

Second Edition

Knut Reinert

Sorin Draghici

Freie Universität Berlin, Germany Series: Chapman & Hall/CRC Mathematical & Computational Biology, 30

Wayne State University, Detroit, Michigan, USA Series: Chapman & Hall/CRC Mathematical & Computational Biology, 4

Written by the founders of the SeqAn project, this book first describes the general library design of SeqAn. It introduces biological sequence analysis problems, discusses the benefit of using software libraries, summarizes the design principles and goals of SeqAn, details the main programming techniques used in SeqAn, and demonstrates the application of these techniques in various examples. Focusing on the components provided by SeqAn, the second part explores basic functionality, sequence data structures, alignments, pattern and motif searching, string indices, and graphs. The last part describes applications of SeqAn to genome alignment, consensus sequence, suffix array construction, and more.

Since the publication of the first edition, the field of microarrays has evolved. This timely second edition replaces the commercial software with the open source R computing environment. Although R code is integrated into the text, users of other programming languages can still benefit from the book. This edition contains new chapters on cutting-edge microarray topics and provides the R code on an accompanying CD-ROM. Richly illustrated in full color, the book continues to bridge the gap between an introduction to data analysis and advanced material for performing data analysis.

Catalog no. C7623, ISBN: 978-1-4200-7623-3 November 2009, 6-1/8 x 9-1/4, 329 pp. Suggested Price: $89.95 / £57.99

Catalog no. K10487, ISBN: 978-1-4398-0975-4 May 2010, 6-1/8 x 9-1/4, 706 pp. Suggested Price: $89.95 / £57.99

Bioinformatics

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m

For more information and a complete list DNA Methylation Microarrays Experimental Design and Statistical Analysis Sun-Chong Wang National Central University, Chungli Taoyuan, Taiwan

Art Petronis Centre for Addiction and Mental Health, Toronto, Ontario, Canada Chapman & Hall/CRC Biostatistics Series, 26

Bioinformatics

Illustrating results with examples based on real data, this book presents the statistical methods and tools to analyze DNA methylation microarray data. It describes wet-bench technologies that produce the data for analysis, explains how to preprocess the data to remove systematic artifacts resulting from measurement imperfections, and explores differential methylation and genomic tiling arrays. The authors show how cluster and network analyses can link the functions and roles of unannotated DNA elements with known ones. They also survey the open source software, public databases, and other online resources available for microarray research. An accompanying CD-ROM contains files of plots and many color images. Catalog no. C6727, ISBN: 978-1-4200-6727-9 April 2008, 6-1/8 x 9-1/4, 256 pp. Suggested Price: $79.95 / £49.99

DNA Microarrays and Related Genomics Techniques Design, Analysis, and Interpretation of Experiments Edited by

David B. Allison, Grier P. Page, T. Mark Beasley, and Jode W. Edwards University of Alabama at Birmingham, USA Chapman & Hall/CRC Biostatistics Series, 15

With contributions from distinguished experts in the field, DNA Microarrays and Related Genomics Techniques parallels the steps in conducting and analyzing a microarray experiment from conception to interpretation. This book explores critical aspects of designing a microarray experiment, including power and sample size. It assesses the validity of statistical methods and describes how to ensure the quality and integrity of data. In addition, the text discusses new methods for interpreting microarray data and examines the various issues associated with analysis. It also addresses the movement to make large high-dimensional datasets public for further analysis, along with the associated methods. Catalog no. DK2187, ISBN: 978-0-8247-5461-7 November 2005, 6-1/8 x 9-1/4, 392 pp. Suggested Price: $93.95 / £59.99

Gene Expression Studies Using Affymetrix Microarrays

Genetics and Randomness Anatoly Ruvinsky University of New England, Australia

With the revolutionary explosion of genetic information discovered in recent decades, it is important to realize the underlying limitations of scientific prediction in genetics. Avoiding unnecessary technical details, this book helps readers accept and embrace a probabilistic view and understand the role of randomness in critical biological processes. It explores the nature of genetic uncertainty from different points of view and at different levels of biological organization. The book also traces the origin of some ideas of randomness starting from the basics of quantum mechanics and molecular genetics to modern evolutionary genetics and the philosophy of mathematics. Catalog no. 78852, ISBN: 978-1-4200-7885-5 July 2009, 6-1/8 x 9-1/4, 160 pp., Soft Cover Suggested Price: $79.95 / £49.99

Glycome Informatics Methods and Applications Kiyoko F. Aoki-Kinoshita Soka University, Hachioji, Tokyo, Japan Series: Chapman & Hall/CRC Mathematical & Computational Biology, 28

One of the few up-to-date books available in this important area, Glycome Informatics covers all known informatics methods pertaining to the study of glycans, which provide crucial functional roles in many biological processes. The book supplies all necessary background information, including glycan classes, motifs, and nomenclature. It offers a complete list of relevant databases and resources on glycobiology and presents a wide range of methods, from computer theory and data mining to glycomics. The author also discusses key points and ideas for potential research projects. Sequence analysis and machine learning methods along with glycomic technologies are described in the appendices. Catalog no. C8334, ISBN: 978-1-4200-8334-7 November 2009, 6-1/8 x 9-1/4, 256 pp. Suggested Price: $89.95 / £57.99

Handbook of Computational Molecular Biology Edited by

Hinrich Göhlmann and Willem Talloen

Srinivas Aluru

Johnson & Johnson, Beerse, Belgium Series: Chapman & Hall/CRC Mathematical & Computational Biology, 23

Iowa State University, Ames, USA Chapman & Hall/CRC Computer & Information Science Series, 9

This book tears down the omnipresent language barriers among molecular biology, bioinformatics, and biostatistics researchers by explaining the entire process of a gene expression study from conception to interpretation. It covers important technical and statistical pitfalls and problems, helping not only to explain concepts outside the domain of researchers, but to provide additional guidance in their field of expertise. The book also describes technical and statistical methods conceptually with illustrative examples, enabling those inexperienced with gene expression studies to grasp the basic principles.

The Handbook of Computational Molecular Biology offers a comprehensive, systematic treatment of computational biology, from the most basic concepts to advanced applications. Algorithmic in nature, the handbook highlights applications to molecular biology through every topic covered. In addition, many of the newer topics in the field are covered in depth, like microarrays, comparative genomics and external memory algorithms, and parallel methods. Written by experts in the field, it covers problems related to understanding genetic diseases, designing drugs tailored to the individual, deciphering the genomes of specific organisms, and understanding the process of evolution.

Catalog no. C6515, ISBN: 978-1-4200-6515-2 July 2009, 6-1/8 x 9-1/4, 359 pp. Suggested Price: $89.95 / £54.99

Catalog no. C061, ISBN: 978-1-58488-406-4 December 2005, 7 x 10, 1104 pp. Suggested Price: $144.95 / £92.00

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Microarray Innovations Technology and Experimentation

Martin Gollery

Edited by

University of Nevada, Reno, USA Series: Chapman & Hall/CRC Mathematical & Computational Biology, 19

Gary Hardiman University of California at San Diego, La Jolla, USA Drug Discovery Series, 11

Demonstrating that many useful resources, such as databases, can benefit most bioinformatics projects, this handbook focuses on how to choose and use various methods and programs available for hidden Markov models (HMMs). It explores HMM implementations important in bioinformatics, including SAM, HMMER, Wise2, PSI-BLAST, and Meta-MEME, and shows how numerous databases and programs, such as Pfam, SMART, SUPERFAMILY, and PANTHER, are used in bioinformatics projects. In addition to problems sets in each chapter and a CDROM of related material, the book discusses the use of HMMs for discovering the homology of a protein family, explains how to build custom HMM databases, and offers solutions to help overcome slow searches.

Microarray technologies and applications have evolved steadily with increasing content and better analytical methodologies. This compendium represents a cross section of the past five years of microarray methods and applications and their usage in drug discovery and biomedical research. Expert contributors cover improvements in automation, new substrates for printing arrays, platform comparisons and contrasts, experimental design, data normalization and mining schemes, and epigenomic array studies. They also review electronic microarrays, comparative genomic hybridization, microRNA arrays, mutational analyses, clinical diagnostic arrays, protein arrays, and neuroscience applications.

Catalog no. C6846, ISBN: 978-1-58488-684-6 June 2008, 6-1/8 x 9-1/4, 176 pp. Suggested Price: $59.95 / £38.99

Catalog no. 94483, ISBN: 978-1-4200-9448-0 April 2009, 7 x 10, 314 pp. Suggested Price: $129.95 / £78.99

Bioinformatics

Handbook of Hidden Markov Models in Bioinformatics

Textbook

Introduction to Machine Learning and Bioinformatics Sushmita Mitra, Sujay Datta, Theodore Perkins, and George Michailidis

Python for Bioinformatics Sebastian Bassi

Series: Chapman & Hall/CRC Computer Science & Data Analysis, 12

Universidad Nacional de Quilmes, Bernal, Argentina Series: Chapman & Hall/CRC Mathematical & Computational Biology, 27

Examining the connections between these two increasingly intertwined areas, this text presents a unifying, thorough, and accessible introduction to the basic ideas and developments in machine learning and bioinformatics. It describes the major problems in bioinformatics and the concepts and algorithms of machine learning. The authors demonstrate the capabilities of key machine learning techniques, such as hidden Markov models and artificial neural networks, and apply stateof-the-art techniques to bioinformatics problems in structural biology, cancer treatment, and proteomics. They also include exercises at the end of some chapters and offer instructional materials on their website.

Based on the author’s experience working for an agricultural biotechnology company, this book helps scientists solve their biological problems by helping them understand the basics of programming. Requiring no prior knowledge of programming-related concepts, it focuses on the easy-to-use, yet powerful, Python computer language. After introducing Python and the Biopython package, the book covers advanced topics, such as XML. It contains working code that solves real-world biological problems and includes a DVD with a ready-to-run virtual machine (VM) based in DNALinux to test the code. Along with other material, the appendices offer installation instructions for VM, Python, and Biopython.

Catalog no. C682X, ISBN: 978-1-58488-682-2 June 2008, 6-1/8 x 9-1/4, 384 pp. Suggested Price: $79.95 / £39.99

Catalog no. C9292, ISBN: 978-1-58488-929-8 September 2009, 6-1/8 x 9-1/4, 587 pp., Soft Cover Suggested Price: $69.95 / £44.99

Meta-analysis and Combining Information in Genetics and Genomics

R Programming for Bioinformatics

Rudy Guerra Rice University, Houston, Texas, USA

Darlene R. Goldstein EPFL SB IMA STAT, Switzerland Series: Chapman & Hall/CRC Mathematical & Computational Biology, 25

This book provides many novel techniques for analyzing data from modern biological studies that involve multiple data sets, either of the same type or multiple data sources. It addresses the combination of similar data types: genotype data from genome-wide linkage scans and data derived from microarray gene expression experiments. The expert contributors show how some data combination problems can arise even within the same basic framework and offer solutions to these problems. They also discuss the combined analysis of different data types, giving readers an opportunity to see data combination approaches in action across a wide variety of genome-scale investigations. Catalog no. C522X, ISBN: 978-1-58488-522-1 July 2009, 6-1/8 x 9-1/4, 360 pp. Suggested Price: $99.95 / £63.99

Robert Gentleman Fred Hutchinson Cancer Research Center, Seatttle, Washington, USA Series: Chapman & Hall/CRC Computer Science & Data Analysis, 13

Drawing on the author’s first-hand experiences as an expert in R, this practical guide focuses on the programming skills needed to use R for the solution of bioinformatics and computational biology problems. It covers the fundamentals of the R language, object-oriented programming in R, and data mark-up and web services languages and tools. The author also examines different aspects of string handling and manipulations; discusses the interfacing of R with other languages, such as C, FORTRAN, Perl, and Python; and explains how to write software packages as well as debug and profile R code. The complete source code is available on the book’s website. Catalog no. C6367, ISBN: 978-1-4200-6367-7 July 2008, 6-1/8 x 9-1/4, 328 pp. Suggested Price: $69.95 / £44.99

For more information and a complete list Statistical and Computational Pharmacogenomics Rongling Wu University of Florida, Gainesville, USA

Min Lin Duke Clinical Research Institute, Durham, North Carolina, USA Chapman & Hall/CRC Interdisciplinary Statistics Series

Bioinformatics

Due to the tremendous accumulation of data for genetic markers, pharmacogenomics, the study of the functions and interactions of all genes in the overall variability of drug response, is one of the hottest areas of research in biomedical science. This volume presents recent developments in statistical methodology with a number of detailed worked examples that outline how these methods can be applied. Comprehensive in scope, the text provides key tools needed to understand and model the genetic variation for drug response and equips statisticians with a thorough understanding of this complex field and how computational skills can be employed. Catalog no. C8288, ISBN: 978-1-58488-828-4 August 2008, 6-1/8 x 9-1/4, 368 pp. Suggested Price: $79.95 / £49.99

Statistics of Medical Imaging Tianhu Lei University of Pennsylvania & Children’s Hospital, Philadelphia, USA Chapman & Hall/CRC Interdisciplinary Statistics Series

More work is being done in the statistical aspects of medical imaging, and this book fills the gap to provide a unified framework of study by presenting a complete look at medical imaging and statistics – from the statistical aspects of imaging technology to the statistical analysis of images. It provides technicians and students with the statistical principles that underlay medical imaging, as required reference material for researchers involved in the design of new technology. Illustrations are included throughout as are many real examples, and algorithms. The text also includes exercises developed out of the author’s many years of experience with studying the statistics of medical imaging. Catalog no. C8842, ISBN: 978-1-4200-8842-7 June 2010, 6-1/8 x 9-1/4, 416 pp. Suggested Price: $99.95 / £63.99

Textbook Textbook

Statistical Physics of Biomolecules An Introduction

Darren J. Wilkinson

University of Pittsburgh, Pennsylvania, USA

Newcastle University, UK Series: Chapman & Hall/CRC Mathematical & Computational Biology, 11

Designed especially for students from non-physics and non-chemistry backgrounds, this book covers elementary statistical mechanics and the thermodynamics necessary to understand fundamental biophysical phenomena. The book maintains a probabilistic view throughout. It presents more than one interpretation of every phenomenon: for example, on- and off-rates are carefully explained in the context of binding affinities and connected back with a microscopic statistical picture, as well as with the standard thermodynamic description. The author explicitly explains the theory behind interpreting the physics and statistics of many experiments.

Although stochastic kinetic models are increasingly accepted as the best way to represent and simulate genetic and biochemical networks, most researchers in the field have limited knowledge of stochastic process theory. Stochastic Modelling for Systems Biology provides an accessible introduction to this theory using examples that are familiar to systems biology researchers. Focusing on computer simulation, the author examines the use of stochastic processes for modelling biological systems. Along with the latest simulation techniques and research material, such as parameter inference, the text includes many examples and figures as well as software code in R for various applications.

Catalog no. 73788, ISBN: 978-1-4200-7378-2 April 2010, 6-1/8 x 9-1/4, 248 pp. Suggested Price: $89.95 / £57.99

Catalog no. C5408, ISBN: 978-1-58488-540-5 April 2006, 6-1/8 x 9-1/4, 280 pp. Suggested Price: $88.95 / £56.99

Textbook

Statistics in Human Genetics and Molecular Biology

An Algorithmic Approach

Daniel M. Zuckerman

Stochastic Modelling for Systems Biology

Cavan Reilly University of Minnesota, Minneapolis, USA Series: Chapman & Hall/CRC Texts in Statistical Science, 82

Structural Bioinformatics Forbes J. Burkowski University of Waterloo, Ontario, Canada Series: Chapman & Hall/CRC Mathematical & Computational Biology, 20

Focusing on the roles of different segments of DNA, this book provides a basic understanding of problems arising in the analysis of genetics and genomics. With many worked examples and end-of-chapter exercises, it presents statistical applications in genetic mapping, DNA/protein sequence alignment, and analyses of gene expression data from microarray experiments. The text covers basic molecular biology, likelihood-based statistics, physical mapping, markers, linkage analysis, parametric and nonparametric linkage, sequence alignment, feature recognition, hidden Markov models, and Bayesian approaches. It also discusses differential gene expression detection as well as classification and cluster analysis using gene expression data sets.

Showcasing the beauty of protein structures, this practical text illustrates how to apply key algorithms to solve problems related to macromolecular structure. It emphasizes a methodology that uses mathematical models to act as links between structural biology and computational algorithms. The author shows that protein structure can produce symmetry and beauty as well as biological function. He also gives many examples of dynamic programming applications, including RNA secondary structure prediction and protein sequence alignment. The text includes problems throughout, exercises at the end of each chapter, and a 12-page color insert.

Catalog no. C7263, ISBN: 978-1-4200-7263-1 June 2009, 6-1/8 x 9-1/4, 280 pp. Suggested Price: $59.95 / £38.99

Catalog no. C6838, ISBN: 978-1-58488-683-9 October 2008, 6-1/8 x 9-1/4, 429 pp. Suggested Price: $79.95 / £49.99

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Includes a CD-ROM

Systems Biology and Bioinformatics: A Computational Approach

Design and Analysis of Bioavailability and Bioequivalence Studies Third Edition BABE-Solution Bundle Version

Kayvan Najarian, Christopher N. Eichelberger, Siamak Najarian, and Shahriar Gharibzadeh

Edited by

Emphasizing computational methods, Systems Biology and Bioinformatics provides an introduction to system biology and its impact on biology and medicine. The book reviews the basic principles of molecular and cell biology using a system-oriented approach, with a brief description of the high-throughput biological experiments that produce databases. The methods presented in the text include techniques to discover genes, perform nucleotide and amino acid sequence matching, and estimate static gene dynamic pathways. The book also explains how to use system-oriented models to predict the behavior of biological systems for important applications such as rational drug design.

Chapman & Hall/CRC Biostatistics Series

Catalog no. 46500, ISBN: 978-1-4200-4650-2 April 2009, 6-1/8 x 9-1/4, 190 pp. Suggested Price: $69.95 / £44.99

Shein-Chung Chow and Jen-pei Liu Containing four new chapters, along with several new and updated sections, this third edition reviews the progress of activities and results in bioavailability and bioequivalence on regulatory requirements, scientific and practical issues, and statistical methodology. It presents the current status of regulations on bioavailability and bioequivalence, including guidelines/guidances issued by the FDA, EMEA, and WHO. This edition addresses frequently asked questions and explores sample size determination, meta-analysis, and pharmacokinetics. It also offers a basic version of PharmaSoftware Solutions, Inc.’s BABE Solution 2008, with bioequivalence assessment for in vivo bioequivalence studies. Catalog no. K10699, ISBN: 978-1-4398-1358-4 March 2009, 6-1/8 x 9-1/4, 760 pp., Pack - Book and CD Suggested Price: $299.95 / £167.00

Biological Data Mining Edited by

Using Artificial Intelligence in Chemistry and Biology

Jake Y. Chen

A Practical Guide

University of California, Riverside, USA Chapman & Hall/CRC Data Mining and Knowledge Discovery Series, 11

Hugh Cartwright Oxford University, UK

In a lucid, straightforward manner, this book explains how Artificial Intelligence (AI) methods are used by scientists and what can be accomplished with them. Designed for those with no prior programming knowledge, this book efficiently and quickly teaches meaningful scientific applications. Using a practical and direct approach, it addresses the needs of scientists across a range of disciplines. Topics include an introduction to artificial intelligence, artificial neural networks, self-organizing maps, growing cell structures, evolutionary algorithms, cellular automata, expert systems, fuzzy logic, learning classifier systems, and evolvable developmental systems. Catalog no. 8412, ISBN: 978-0-8493-8412-7 May 2008, 6-1/8 x 9-1/4, 360 pp. Suggested Price: $129.95 / £82.00

Adaptive Design Theory and Implementation Using SAS and R

Indiana University-Purdue University, Indianapolis, USA

Stefano Lonardi

This volume presents comprehensive data mining concepts, theories, and applications in current biological and medical research. The first section of the book discusses challenge and opportunities in analyzing and mining biological sequences and structures to gain insight into molecular functions. The second section addresses emerging computational challenges in interpreting highthroughput Omics data. The book then describes the relationships between data mining and related areas of computing, including knowledge representation, information retrieval, and data integration for structured and unstructured biological data. The last part explores data mining opportunities for biomedical applications. Catalog no. C6847, ISBN: 978-1-4200-8684-3 September 2009, 6-1/8 x 9-1/4, 733 pp. Suggested Price: $99.95 / £63.99

Textbook

Biostatistics A Computing Approach

Mark Chang

Stewart Anderson

AMAG Pharmaceuticals, Inc, Lexington, Massachusetts, USA Chapman & Hall/CRC Biostatistics Series, 22

University of Pittsburgh, Pennsylvania, USA Series: Chapman & Hall/CRC Texts in Statistical Science

This book provides a concise, unified presentation of adaptive design theories, uses SAS and R for the design and simulation of adaptive trials, and illustrates how to master different adaptive designs through real-world examples. It emphasizes the relationships among different methods; covers regulatory views; discusses the challenges in planning, executing, analyzing, and reporting adaptive designs; and features Bayesian decision theory to optimize adaptive designs and programs. The author also explores controversial issues surrounding statistical theories as well as fruitful avenues for future research and applications of adaptive designs.

Focusing on visualization and computational approaches with an emphasis on the importance of simulation, Biostatistics: A Computing Approach introduces modern and classical biostatistical methods and compares their respective usefulness. The book covers essential topics in biostatistical science, including simple linear regression, multivariate regression, repeated measure, nonparametric analysis, survival analysis, sample size, and power calculations. Assuming only basic knowledge of probability and statistics, the text offers numerous practical applications and detailed worked examples taken from the medical area, all computed using R and SAS, as well as exercises with solutions.

Catalog no. C962X, ISBN: 978-1-58488-962-5 June 2007, 6-1/8 x 9-1/4, 440 pp. Suggested Price: $89.95 / £57.99

Bioinformatics / Biostatistics

Textbook

Catalog no. C8342, ISBN: 978-1-58488-834-5 June 2010, 6-1/8 x 9-1/4, 416 pp., Soft Cover Suggested Price: $79.95 / £39.99

For more information and a complete list Correlated Frailty Models in Survival Analysis Andreas Wienke Institute of Medical Epidemiology, Wittenberg, Germany Chapman & Hall/CRC Biostatistics Series

Biostatistics

Written by a recognized authority in frailty models, Correlated Frailty Models in Survival Analysis provides an introduction and extensive overview of gathered information on survival data that pertains to random effects. Applications in medicine, including clinical trials, (genetic) epidemiology, and demography, are presented from real data, which are then used as examples of modeling strategies. Accessible to readers with only a basic knowledge of survival analysis, the book extends the standard Cox model. Catalog no. C7388, ISBN: 978-1-4200-7388-1 May 2010, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $99.95 / £63.99

Textbook

Design and Analysis of Experiments with Examples of SAS John Lawson Brigham Young University, Provo, Utah, USA Series: Chapman & Hall/CRC Texts in Statistical Science

Textbook

Design of Experiments An Introduction Based on Linear Models Max Morris Iowa State University, Ames, USA Series: Chapman & Hall/CRC Texts in Statistical Science

This text enables a better appreciation of the fundamental issues involved in designing experiments. Each chapter contains a description of several experiments taken from the applied science and engineering literature. The author uses designs as the basis to discuss topics, such as blocking, units, and randomization. He covers data analysis through the specific form of the reduced normal equation for each design, basic hypothesis tests, and confidence intervals. The text also explores graphical procedures for presenting data and checking the usual linear model assumptions. It includes statistical computing material in the appendix and the S-Plus and R codes from the book are available online. Catalog no. C9233, ISBN: 978-1-58488-923-6 May 2010, 6-1/8 x 9-1/4, 576 pp. Suggested Price: $89.95 / £39.99

Handbook of Statistics in Clinical Oncology Second Edition Edited by

John Crowley Cancer Research & Biostatistics, Seattle, Washington, USA

Donna Pauler Ankerst Fred Hutchinson Cancer Center, Washington, USA

While most books on the design of experiments emphasize the mechanics of computation, this text minimizes that distraction with the use of the SAS. Especially practical due to the author’s extensive work as a consultant, the book connects the objectives of the research to the type of experimental design required. It describes the process for choosing the appropriate design, creating the design, collecting the data, determining the proper model, fitting the model to the data, and interpreting results. The projects in the book encourage readers to design and perform simple experiments. Code, data sets, and ancillary materials are available for download from the author’s website.

A compendium of modern statistical approaches to solving problems in clinical oncology, this book focuses on clinical trials in phases I, II, and III, proteomic and genomic studies, complementary outcomes and exploratory methods. Cancer Forum called the first edition “a good reference book for statisticians who will be designing and analyzing cancer trials.” The second edition includes over 1000 references, more than 40 world-renowned contributors, and 300 equations, tables, and drawings. Completely revised while keeping the features that made the first edition a bestseller, this book is a valuable source for statistical approaches to research in clinical medicine.

Catalog no. C6060, ISBN: 978-1-4200-6060-7 June 2010, 6-1/8 x 9-1/4, 576 pp. Suggested Price: $99.95 / £63.99

Catalog no. DK3170, ISBN: 978-0-8247-2339-2 December 2005, 6-1/8 x 9-1/4, 640 pp. Suggested Price: $89.95 / £57.99

Textbook

Hierarchical Modeling and Analysis for Spatial Data

Design of Experiments and Linear Regression in the Biological Sciences

Sudipto Banerjee and Brad P. Carlin University of Minnesota, Minneapolis, USA

Alan E. Gelfand

Salvador Alejandro Gezan, Suzanne Jane Clark, Suzanne Jane Welham, and Andrew Mead

Duke University, Durham, North Carolina, USA Series: Chapman & Hall/CRC Monographs on Statistics & Applied Probability, 101

Written in simple language with relevant examples, this illustrative introductory book presents best practices in experimental design and simple data analysis. Taking a practical and intuitive approach, it only uses mathematical formulae to formalize the methods where necessary and appropriate. The text features extended discussions of examples that include real data sets arising from research. The authors analyze data in detail to illustrate the use of basic formulae for simple examples while using the GenStat® statistical package for more complex examples. Each chapter offers instructions on how to obtain the example analyses in GenStat and R.

Hierarchical Modeling and Analysis for Spatial Data is an accessible treatment of Bayesian methods, modeling, and data analysis for spatial and spatio-temporal data. Self-contained, it includes overviews of the necessary background material, exercises, and a brief tutorial on using S+SpatialStats, geoR, and WinBUGS software for hierarchical spatial modeling. This book provides clear explanations, plentiful illustrations – some in full color – and lays the groundwork for using easily accessible software to immediately apply the techniques to your data. Written by a team of leaders in the field, it will undoubtedly remain the primary textbook and reference on the subject for years to come.

Catalog no. K10432, ISBN: 978-1-4398-0878-8 June 2010, 6-1/8 x 9-1/4, 352 pp. Suggested Price: $79.95 / £49.99

Catalog no. C410X, ISBN: 978-1-58488-410-1 December 2003, 6 x 9, 472 pp. Suggested Price: $88.95 / £56.99

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Textbook

Second Edition

Modelling Survival Data in Medical Research Second Edition David Collett

University of Aarhus, Denmark

UK Transplant, Bristol Series: Chapman & Hall/CRC Texts in Statistical Science, 57

This book focuses on the analyses used most often in health research. It covers various graph types, calculation commands, commands to modify data set structure, simple analyses of categorical and continuous variables, regression models, incidence and survival analysis, and measurement and diagnosis. This edition encompasses several of the new features in Stata 10, such as the graph editor and date-and-time variables, as well as an added section with exercises. The author stresses the importance of good documentation habits to prevent errors and wasting time. He also provides robust examples with downloadable data sets on the book’s website.

Survival analysis is an active field, and many advances have emerged during the past decade. Modelling Survival Data in Medical Research, Second Edition expands on the highly successful first edition, which was praised for its clarity, content, and accessibility. This edition presents up-to-date modelling techniques in survival data analysis, including recent developments in model checking, parametric models, time-dependent variables, and interval censored data. For this edition, the author focused the software sections on SAS-the software of choice in medical and bio-statistics. The text includes many practical examples drawn from the medical and pharmaceutical sciences.

Catalog no. SZ0440, ISBN: 978-1-59718-044-3 September 2008, 7 3/8 x 9 1/4, 340 pp., Soft Cover Suggested Price: $69.95 / £46.99

Catalog no. C3251, ISBN: 978-1-58488-325-8 March 2003, 6-1/8 x 9-1/4, 408 pp., Soft Cover Suggested Price: $73.95 / £46.99

Svend Juul

An Introduction to Survival Analysis Using Stata Second Edition

Textbook

Practical Statistics for Medical Research Douglas G. Altman

Mario Cleves, William Gould, Roberto Gutierrez, and Yulia Marchenko

Centre for Statistics in Medicine, Oxford, UK Series: Chapman & Hall/CRC Texts in Statistical Science, 12

Written by the developers of Stata’s widely used survival analysis suite, this book provides the foundation to understand various approaches for analyzing time-to-event data. The authors discuss how survival analysis estimators work and what information they exploit. They also present the syntax, features, and underpinnings of Stata’s survival analysis routines. This edition highlights the new aspects of Stata 10, including its power and sample-size calculations for survival data. Other updates include in-graph at-risk tables for Kaplan–Meier and related curves, survival analysis for survey data, and regression models with flexible functional forms via fractional polynomials.

Practical Statistics for Medical Research is a problem-based text for medical researchers, medical students, and others in the medical arena who need to use statistics but have no specialized mathematics background. The author draws on 20 years of experience as a consulting medical statistician to provide clear explanations to key statistical concepts, with a firm emphasis on practical aspects of designing and analyzing medical research. Using real data and including dozens of interesting data sets, this bestselling text gives special attention to the presentation and interpretation of results and the many real problems that arise in medical research.

Catalog no. SZ0416, ISBN: 978-1-59718-041-2 May 2008, 7 3/8 x 9 1/4, 363 pp., Soft Cover Suggested Price: $79.95 / £49.99

Catalog no. C7630, ISBN: 978-0-412-27630-9 November 1990, 6-1/8 x 9-1/4, 624 pp. Suggested Price: $93.95 / £59.99

Textbook

Randomization, Bootstrap and Monte Carlo Methods in Biology

Medical Biostatistics Second Edition

Biostatistics

An Introduction to Stata for Health Researchers

Abhaya Indrayan

Third Edition

University College of Medical Science, Delhi, India Chapman & Hall/CRC Biostatistics Series, 7

Bryan F.J. Manly

Demonstrating how biostatistics helps manage medical uncertainties, this comprehensive edition covers numerous biostatistical methods used in evidencebased patient management, medical research, and health administration. Added chapters describe clinical trials, observational studies, laboratory experiments, survival analysis, logistic regression, and clinimetrics. With more real-world examples, this edition also expands discussions on epistemic uncertainties, crossover designs, and equivalence trials. In addition to conventional statistical procedures, it discusses reliability and validity evaluations, quality control methods, and the robustness of results.

Modern computer-intensive statistical methods play a key role in solving many problems across a wide range of scientific disciplines. This new edition of a bestseller illustrates the value of a number of these methods with an emphasis on biological applications. The book has been updated to reflect developments in methodology, computing, and applications and features extensively revised chapters on bootstrap and Monte Carlo methods that incorporate many new applications. The author also includes new information on time series and multivariate, survival, and growth data and provides an expanded appendix on software for computational statistics.

Catalog no. C8873, ISBN: 978-1-58488-887-1 March 2008, 6-1/8 x 9-1/4, 824 pp. Suggested Price: $99.95 / £55.99

Catalog no. C5416, ISBN: 978-1-58488-541-2 August 2006, 6-1/8 x 9-1/4, 480 pp. Suggested Price: $83.95 / £53.99

Western EcoSystem Technology, Inc., Laramie, Wyoming, USA

For more information and a complete list Statistical Analysis for Decision Makers in Healthcare Second Edition, Understanding and Evaluating Critical Information in Changing Times

Biostatistics / Biostatistics-Clinical Trials 78

Translational Medicine Strategies and Statistical Methods Edited by

Dennis Cosmatos Parexel International, Rydal, Pennsylvania, USA

Shein-Chung Chow

Futures Practice, ACS Health Care Solutions, Chicago, Illinois, USA

Duke University School of Medicine, Durham, North Carolina, USA Chapman & Hall/CRC Biostatistics Series, 28

Designed for the busy healthcare professional who needs to collect, analyze, and/ or evaluate data, this readily accessible work explains the fundamental concepts, uses, and misuses of statistics. Without jargon or mathematical formulas, the author introduces the practice of quantitative analysis to provide an understanding of the principles of scientific inquiry, applied to clinical medicine, program evaluation, policy analysis, management, accounting, and research. The book discusses practical scientific methods to show why statistics cannot compensate for bad science or bad data. It will help readers to intelligently evaluate the many numbers that cross their desk in the normal course of business.

Translational medicine has become increasingly important in pharmaceutical research development. Translational Medicine: Strategies and Statistical Methods examines the critical decisions that must be made to successfully transition from basic to clinical science. With a review of existing processes, the book presents a detailed discussion of alternative research approaches that lead to faster and more accurate decisions on data. It provides insight on biomarker development in early phase clinical trials, integrates genomic and clinical databases for the establishment of medical predictive models in various diseases, and reviews the design and analysis for translating research findings.

Catalog no. K10061, ISBN: 978-1-4398-0076-8 May 2009, 6 x 9, 160 pp., Soft Cover Suggested Price: $49.95 / £30.99

Catalog no. C8725, ISBN: 978-1-58488-872-7 December 2008, 6-1/8 x 9-1/4, 224 pp. Suggested Price: $89.95 / £57.99

Jeffrey C. Bauer

Textbook

Statistical Analysis of Medical Data Using SAS Geoff Der University of Glasgow, Scotland, UK

Brian S. Everitt

Bayesian Adaptive Methods for Clinical Trials Donald A. Berry, Scott M. Berry, Bradley P. Carlin, J. Jack Lee, and Peter Muller

King’s College, University of London, UK

Chapman & Hall/CRC Biostatistics Series

Statistical Analysis of Medical Data Using SAS demonstrates how to use SAS to analyze medical data. Der and Everitt, authors of the bestselling Handbook of Statistical Analyses Using SAS, bring all of their considerable talent and experience to bear in this book. Each chapter briefly describes a particular procedure, focusing on using SAS to implement it, and properly interpreting the output. Step-by-step instructions, lucid explanations, clear examples, and many exercises combine to form an outstanding, self-contained guide suitable for medical researchers and statisticians alike using SAS to analyze medical data. All of the code and data sets used in the book are available for download from the Internet.

Driven by modern computing capabilities, there has been a rapid increase of interest in Bayesian methods for the analysis of clinical trial data. This book provides an introduction to Bayesian adaptive methods for the design and analysis of clinical trials. It presents background material on Bayesian inference and covers clinical trials in Phases I, II, and III. The methods are illustrated with many detailed examples and case studies using real data obtained by the authors in their extensive work. The examples are implemented using R and WinBUGS software, which is made available on a supporting website.

Catalog no. C469X, ISBN: 978-1-58488-469-9 September 2005, 6-1/8 x 9-1/4, 440 pp. Suggested Price: $88.95 / £56.99

Catalog no. K11217, ISBN: 978-1-4398-2548-8 June 2010, 6-1/8 x 9-1/4, 288 pp. Suggested Price: $89.95 / £57.99

Testing Statistical Hypotheses of Equivalence and Noninferiority

Clinical Trials in Oncology

Second Edition Stefan Wellek

Stephanie Green, John Crowley, Jacqueline Benedetti, and Angela Smith

Second Edition

Central Institute of Mental Health, Germany

Chapman & Hall/CRC Interdisciplinary Statistics Series, 10

The statistical concept of equivalence has gained considerable importance during the past two decades, with applications in medical and biopharmaceutical research. This book provides a comprehensive treatment of statistical equivalence testing. The author addresses a spectrum of specific, two-sided equivalence testing problems, from the one-sample problem with normally distributed observations of fixed known variance to problems involving several samples and multivariate data. The treatment includes a review of basic mathematical results, and the author makes available on the Internet a collection of computer programs that allow easy implementation of the methods presented.

The new edition of the bestselling Clinical Trials in Oncology provides a concise, nontechnical, and thorough review of methods and issues related to clinical trials. The authors emphasize the importance of proper study design, analysis, and data management and identify the pitfalls inherent in these processes. This edition includes an added section covering innovations in Phase I designs and another on overcoming the challenges of array data. As always, the authors use clear, lucid prose, and a multitude of real-world trials as examples to convey the principles of successful trials without the need for a strong statistics or mathematics background.

Catalog no. K10408, ISBN: 978-1-4398-0818-4 June 2010, 6-1/8 x 9-1/4, 416 pp. Suggested Price: $99.95 / £63.99

Catalog no. C3022, ISBN: 978-1-58488-302-9 July 2002, 6-1/8 x 9-1/4, 280 pp. Suggested Price: $104.95 / £66.99

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Richard J. Hayes London School of Hygiene & Tropical Medicine, UK

Design and Analysis of Quality of Life Studies in Clinical Trials

Lawrence H. Moulton

Second Edition

Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA Chapman & Hall/CRC Interdisciplinary Statistics Series

Diane L. Fairclough University of Colorado Health Sciences Center, Denver, USA Chapman & Hall/CRC Interdisciplinary Statistics Series, 24

Exploring the design, conduct, and analysis of CRTs, this book presents simple methods that are easy to apply with readily available statistical software and that perform well under the conditions experienced in most CRTs. It provides substantial material on study design options and includes a variety of practical examples from both developing and industrialized countries, with many of the examples based on the authors’ own research. The book also illustrates the application of analytical methods through several data sets from actual trials and shows how data can be analyzed using Stata. The data sets are available for download online.

Using SAS, SPSS, and R, this book addresses design and analysis aspects in enough detail so that readers can apply statistical methods to their own longitudinal studies. This edition includes a new chapter on testing models that involve moderation and mediation, a new chapter on QALYs and QTWiST specific to clinical trials, and recent methodological developments for the analysis of trials with missing data. It also presents revised discussions of multiple comparisons procedures that focus on the integration of HRQoL outcomes with other study outcomes using gatekeeper strategies. Data sets, examples, applications, and SAS, R, and SPSS code are available on the book’s website.

Catalog no. C8164, ISBN: 978-1-58488-816-1 January 2009, 6-1/8 x 9-1/4, 338 pp. Suggested Price: $89.95 / £54.99

Catalog no. C6117, ISBN: 978-1-4200-6117-8 January 2010, 6-1/8 x 9-1/4, 411 pp. Suggested Price: $89.95 / £57.99

Textbook

Data and Safety Monitoring Committees in Clinical Trials

Introduction to Randomized Controlled Clinical Trials Second Edition

Jay Herson

John N.S. Matthews

John Hopkins University, Baltimore, Maryland, USA Chapman & Hall/CRC Biostatistics Series, 30

The University of Newcastle, Newcastle upon Tyne, UK Series: Chapman & Hall/CRC Texts in Statistical Science, 69

Intended to address the practical clinical and statistical issues that arise in pharmaceutical trials, this book summarizes the author’s experience in serving on many DMCs and in heading up a contract research organization that provided statistical support to nearly 75 DMCs. It explains the difference in DMC operations between the pharmaceutical industry and NIH-sponsored trials. Leading you through types of reports for adverse events and lab values, the author presents the statistical requirements of data monitoring committees and gives advice on how statisticians can best interact with its physician members.

Focusing on the important role that statistical methods play in the analysis of the data collected and in the overall clinical trial process, Introduction to Randomized Controlled Clinical Trials provides a concise and accessible introduction to clinical trials. This second edition features added and updated references, examples, exercises, and material on binary outcomes and survival analysis. It features numerous real examples taken from The Lancet, exercises at the end of the chapter, and solutions in an appendix. Ideal for advanced undergraduate and graduate students, the author uses Minitab and R software throughout the text for implementing the methods presented.

Catalog no. C7037, ISBN: 978-1-4200-7037-8 March 2009, 6-1/8 x 9-1/4, 191 pp. Suggested Price: $89.95 / £54.99

Catalog no. C6242, ISBN: 978-1-58488-624-2 June 2006, 6-1/8 x 9-1/4, 304 pp., Soft Cover Suggested Price: $62.95 / £39.99

Design and Analysis of Clinical Trials with Time-to-Event Endpoints

Textbook

Karl E. Peace

Thomas D. Cook and David L. DeMets

Georgia Southern University, Statesboro, USA Chapman & Hall/CRC Biostatistics Series, 31

University of Wisconsin, Madison, USA Series: Chapman & Hall/CRC Texts in Statistical Science

This resource provides a thorough presentation of the design, monitoring, analysis, and interpretation of clinical trials in which time-to-event is of critical interest. Incorporating the collaborations of truly world-class statisticians, it discusses the design and monitoring of Phase II and III clinical trials with timeto-event endpoints. The book presents parametric, semiparametric, categorical, and Bayesian inferential and descriptive methods for analyzing time-to-event endpoints and covers numerous clinical trial applications, including analgesic, antibiotic, antiviral, cancer and cardiovascular prevention, optimal assignment of treatments, adverse events, and carcinogenicity.

This text provides a solid understanding of the various statistical topics relevant to the design, monitoring, and analysis of a clinical trial. It covers basic experimental design, sample size, randomization procedures, interim and survival analyses, quality of life assessment, and longitudinal methods. The book describes all phases of a clinical trial and explores the advantages of and objections to the intent-to-treat principle as well as its implementation. With exercises at the end of most chapters, it also illustrates methods using examples with real data from a variety of disease areas, including heart and lung diseases, cancer, and AIDS.

Catalog no. C6639, ISBN: 978-1-4200-6639-5 April 2009, 6-1/8 x 9-1/4, 616 pp. Suggested Price: $99.95 / £60.99

Biostatistics-Clinical Trials

Cluster Randomised Trials

Introduction to Statistical Methods for Clinical Trials

Catalog no. C0005, ISBN: 978-1-58488-027-1 November 2007, 8-1/2 x 11, 464 pp. Suggested Price: $73.95 / £46.99

For more information and a complete list Textbook

Epidemiology Sample Sizes for Clinical Trials

Biostatistics-Clinical Trials / Epidemiology 80

Steven A. Julious University of Sheffield, UK

With worked examples and problems based on real-world scenarios, this book takes readers through the process of calculating the sample size for many types of clinical trials. It covers the most common types of clinical trials across all phases. The author discusses how assumptions made in a sample size calculation can impact the calculation. He provides calculations for many of the trials and offers hints and tips on how to optimize the calculations. He also illustrates the steps involved in determining sample size, from defining the trial objective to selecting an appropriate endpoint. Catalog no. C7397, ISBN: 978-1-58488-739-3 August 2009, 6-1/8 x 9-1/4, 317 pp. Suggested Price: $79.95 / £48.99

Bayesian Disease Mapping

Study Design and Data Analysis, Second Edition Mark Woodward Mount Sinai Medical Centre, New York, USA Series: Chapman & Hall/CRC Texts in Statistical Science

Discussing techniques used in report writing, models for diagnostics, and design issues, this book covers the spectrum of statistical principles and analytical tools used in epidemiological research. This second edition includes added material on systematic evaluation, meta-analysis, regression dilution, case-cohort studies, casecrossover studies, pooled logistic regression and a companion website containing data sets for examples and exercises, SAS and Stata code for examples, a sample size calculator, and a SAS floating absolute risk macro. The author favors the use of basic mathematics and practical methods over complicated mathematical proofs, making the book comprehensive yet accessible. Catalog no. C415X, ISBN: 978-1-58488-415-6 November 2004, 6-1/8 x 9-1/4, 872 pp. Suggested Price: $93.95 / £46.99

Hierarchical Modeling in Spatial Epidemiology

Forensic Epidemiology

Andrew B. Lawson

Steven A. Koehler and Peggy A. Brown

University of South Carolina, Columbia, USA Chapman & Hall/CRC Interdisciplinary Statistics Series

Point Park University, Pittsburgh, Pennsylvania, USA Series: International Forensic Science and Investigation, 19

This work provides an overview of the main areas of Bayesian hierarchical modeling and its application to the geographical analysis of disease. It explores a range of topics in Bayesian inference and modeling, including Markov chain Monte Carlo methods, Gibbs sampling, the Metropolis–Hastings algorithm, goodness-of-fit measures, and residual diagnostics. The author explains how to apply these methods to disease mapping using numerous real-world data sets pertaining to cancer, asthma, epilepsy, foot and mouth disease, influenza, and other diseases. Data sets, WinBUGS ODC files, and R code are available on the author’s website.

Forensic epidemiology provides an investigative response to public health issues and events that may be linked to criminal activities. After the events of 9/11, the field emerged as a leading tool of investigation, partnering public health officers with law enforcement like never before. This book demonstrates the important role of forensic epidemiology in public health, the medical community, and the legal system. Emphasizing the importance of understanding the terminology and procedures of each field in order to work together effectively, the text explains methods to collect, analyze, and interpret data for criminal investigations using a variety of illustrations and real-world case studies.

Catalog no. C8407, ISBN: 978-1-58488-840-6 August 2008, 6-1/8 x 9-1/4, 368 pp. Suggested Price: $79.95 / £49.99

Catalog no. 63278, ISBN: 978-1-4200-6327-1 August 2009, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $129.95 / £82.00

Causal Inference

Handbook of Spatial Statistics

Miguel A. Hernan and James M. Robins Harvard School of Public Health, Boston, Massachusetts, USA Series: Chapman & Hall/CRC Monographs on Statistics & Applied Probability

The application of causal inference methods is growing exponentially in fields that deal with observational data. Written by pioneers in the field, this practical book presents an authoritative yet accessible overview of the methods and applications of causal inference. With a wide range of detailed, worked examples using real epidemiologic data as well as software for replicating the analyses, the text provides a thorough introduction to the basics of the theory for non-timevarying treatments and the generalization to complex longitudinal data. Catalog no. C7616, ISBN: 978-1-4200-7616-5 June 2010, 6-1/8 x 9-1/4, 352 pp. Suggested Price: $79.95 / £49.99

Alan E. Gelfand, Montserrat Fuentes, Peter Guttorp, and Peter Diggle Series: Chapman & Hall/CRC Handbooks of Modern Statistical Methods, 2

The past few decades have seen a huge increase in the amount of spatial statistics research. This single volume provides a comprehensive, coherent, and unified summary of the entire field. Divided into broad sections, the text addresses topics in the areas of continuous spatial variation, discrete spatial variation, spatial point patterns, and spatio-temporal analysis. A separate section presents additional topics of interest, such as boundary analysis, ecological bias, and multivariate spatial process models. Leading contributors present balanced coverage of methodology and practical application through the inclusion of worked examples using real data as well as detailed case studies. Catalog no. C7287, ISBN: 978-1-4200-7287-7 February 2010, 7 x 10, 904 pp. Suggested Price: $99.95 / £63.99

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Textbook

Poh-Chin Lai, Fun-Mun So, Ka-Wing Chan

Veterinary Clinical Epidemiology, Third Edition Ronald D. Smith University of Illinois College of Veterinary Medicine, UrbanaChampaign, USA

University of Hong Kong

Compiled with method descriptions and step-by-step procedures, the Spatial Epidemiological Approaches in Disease Mapping and Analysis equips readers with the skills needed to prepare health-related data in the proper format, process the data using relevant functions and software, and display the results as mapped or statistical summaries. Describing the wide range of available methods and key GIS concepts for spatial epidemiology, this book illustrates the utilities of the software using real-world data. Additional topics include geographic data models, address matching, geostatistical analysis, universal kriging, point pattern analysis, kernel density, spatio-temporal display, and disease surveillance.

Veterinary Clinical Epidemiology, Third Edition serves as both a teaching resource and a reference on the application of epidemiologic methods in veterinary clinical research. The edition of this successful book continues its focus on observations of naturally or spontaneously occurring diseases. This well-illustrated text includes discussion of applications of epidemiology in medical decision making at the individual and herd levels, details the relevance of epidemiology to companion animal, food animal, and population medicine, and describes applications of molecular diagnostic tools and advanced statistical techniques. It includes many case studies and examples from veterinary literature.

Catalog no. 45466, ISBN: 978-1-4200-4546-8 August 2008, 6-1/8 x 9-1/4, 194 pp. Suggested Price: $79.95 / £55.99

Catalog no. 1566, ISBN: 978-0-8493-1566-4 September 2005, 7 x 10, 280 pp. Suggested Price: $109.95 / £57.99

Cell Mechanics Statistical Thinking in Epidemiology Yu-Kang Tu and Mark S. Gilthorpe University of Leeds, UK

Addressing issues that have plagued researchers throughout the past decade, this book provides new insights into the many existing problems in statistical modeling and offers several alternative strategies to approach these problems. Emphasizing the importance of statistical thinking behind all analyses, the authors use specific examples in epidemiology to illustrate different model specifications that can imply different sets of causal relationships between variables. Each model is interpreted with regard to the context of implicit or explicit causal relationships. The authors also use vector geometry where applicable to provide an intuitive understanding of important statistical concepts. Catalog no. K10018, ISBN: 978-1-4200-9991-1 June 2010, 6-1/8 x 9-1/4, 256 pp. Suggested Price: $89.95 / £57.99

From Single Scale-Based Models to Multiscale Modeling Arnaud Chauvière, Luigi Preziosi, and Verdier Claude Series: Chapman & Hall/CRC Mathematical & Computational Biology, 29

Bringing together experts in cell mechanics, this volume discusses problems and methods relevant to research at the subcellular, cellular, and tissular levels, with special consideration given to multiscale approaches. The first chapters deal with single cells and cell migration, discussing aspects of microrheology and cell adhesion. Middle chapters consider cell mechanics under the influence of the environment. The final chapters move on to more complex multi-cellular situations, including cell-cell interactions, tissues, and tumors. The authors provide biological, mechanical, and physical approaches. Models issued from different approaches are provided that have application to real biological situations. Catalog no. C4548, ISBN: 978-1-4200-9454-1 January 2010, 6-1/8 x 9-1/4, 456 pp. Suggested Price: $119.95 / £76.99

Textbook Textbook

Statistics for Epidemiology Nicholas P. Jewell University of California, Berkeley, USA Series: Chapman & Hall/CRC Texts in Statistical Science, 58

Differential Equations and Mathematical Biology Second Edition D.S. Jones, M.J. Plank, and B.D. Sleeman Series: Chapman & Hall/CRC Mathematical & Computational Biology, 31

Written by one of the top biostatisticians in the field, Statistics for Epidemiology fills a substantial niche by explaining the ideas behind the analysis of epidemiological data without requiring a high level of mathematics or resorting to a cookbook format. It covers the basic material for analyzing data that arise from simple epidemiological studies, including case-control and matched studies. Methodologically, it describes stratification techniques for handling confounding and interaction and the logistic regression model. The author uses a case-study approach, following a few simple examples through several method chapters rather than introducing a different example at each stage.

Ideal for courses on differential equations with applications to mathematical biology or as an introduction to mathematical biology, this bestselling text introduces the fundamental modeling and analytical techniques used to understand biological phenomena. It discusses the modeling of biological behavior, including the heartbeat cycle, chemical reactions, nerve pulses, predator–prey models, and epidemics. This expanded edition includes an added section on spiral waves, recent developments in tumor biology, and additional examples and exercises. It also offers more on the numerical solution of differential equations and numerical bifurcation analysis, providing downloadable MATLAB® files online.

Catalog no. C4339, ISBN: 978-1-58488-433-0 August 2003, 6-1/8 x 9-1/4, 352 pp. Suggested Price: $83.95 / £53.99

Catalog no. C8357, ISBN: 978-1-4200-8357-6 November 2009, 6-1/8 x 9-1/4, 462 pp. Suggested Price: $79.95 / £34.99

Epidemiology / Mathematics for Biology & Medicine

Spatial Epidemiological Approaches in Disease Mapping and Analysis

For more information and a complete list Textbook

An Introduction to Dynamical Systems for Biological Modeling

Thomas S. Deisboeck

Fred Brauer

Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA

University of British Columbia, Vancouver, Canada

Georgio S. Stamatakos

Christopher Kribs-Zaleta

Mathematics for Biology & Medicine 82

Multiscale Cancer Modeling

University of Texas at Arlington, USA Series: Chapman & Hall/CRC Mathematical & Computational Biology

Taking more of a qualitative rather than computational approach, this text presents the techniques required to undertake basic modeling of biological systems through the development and analysis of dynamical systems. It includes many different types of applications from population biology and epidemiology. Keeping technical details to a minimum, the text only requires a basic understanding of calculus. It provides examples of problems with solutions followed by exercises to reinforce the examples. Many of the problems are somewhat challenging so as to encourage a deeper understanding and prompt the use of mathematics in learning about biology. Catalog no. C664X, ISBN: 978-1-4200-6641-8 May 2010, 6-1/8 x 9-1/4, 480 pp. Suggested Price: $89.95 / £39.99

Kinetic Modelling in Systems Biology Oleg Demin Moscow State University, Russia

Igor Goryanin University of Edinburgh, Scotland Series: Chapman & Hall/CRC Mathematical & Computational Biology, 21

Focusing on one of the main pillars in the future development of systems biology, this book explores the kinetic modelling approach and how to apply it to solve real-life problems. It covers model creation techniques, model verification and validation, and simulations and interpretation of biological results. The authors describe underlying algorithms for selected reference methods and present several examples of applications, ranging from drug safety mechanisms to multiple target identification analysis to optimization of E. coli amino acid biosynthesis. The accompanying CD-ROM contains pathway diagrams, model examples, EPE software, and DBSolve installation. Catalog no. C6676, ISBN: 978-1-58488-667-9 October 2008, 6-1/8 x 9-1/4, 360 pp. Suggested Price: $79.95 / £49.99

Textbook

Mathematical and Experimental Modeling of Physical and Biological Processes H.T. Banks and H.T. Tran North Carolina State University, Raleigh, USA Series: Textbooks in Mathematics, 4

Exploring how mathematics is applied to problems in science and engineering, this book discusses mathematical modeling in the context of case study problems that arise in industry and government laboratories. It covers thermal imaging and detection, dynamic properties of beams, acoustics and fluid transport, and size-structured population dynamics for marine populations. The text explains physical and biological relationships and mechanisms through a first principlesbased fundamental modeling approach. It also emphasizes model validation through specific laboratory experiments as well as data collection and analysis. Catalog no. C7337, ISBN: 978-1-4200-7337-9 January 2009, 6-1/8 x 9-1/4, 298 pp. Suggested Price: $79.95 / £48.99

National Technical University of Athens, Zografou, Greece Series: Chapman & Hall/CRC Mathematical & Computational Biology

Computational and mathematical cancer modeling has already become a major driving force behind interdisciplinary cancer systems biology. Understanding tumors as a complex biosystem involves finding ways to investigate and ultimately to target their many constituents and dynamic relationships across multiple scales in space and time. In other words, it requires a detailed understanding of multiscale modeling and simulation. Featuring international contributors who are key players in this important field, this book provides a comprehensive introduction to multiscale cancer modeling. It offers an accessible approach, making it useful for advanced work in cancer modeling. Catalog no. K10739, ISBN: 978-1-4398-1440-6 May 2010, 6-1/8 x 9-1/4, 256 pp. Suggested Price: $89.95 / £57.99

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Adaptive Design Theory and Implementation Using SAS and R...............................................................75

Basic Pharmacokinetics.....................................................69

Biomedical Engineering Principles....................................45

Basic Pharmacology: Understanding Drug Actions and Reactions...........................................................................69

Biomedical Image Analysis................................................49

Adipose Tissue and Inflammation.....................................23

Basic Statistics and Pharmaceutical Statistical Applications, Second Edition..................................................................61

Advanced Nutrition: Macronutrients, Micronutrients, and Metabolism................................................................23

Bayesian Adaptive Methods for Clinical Trials...................78

Advanced Quantitative Microbiology for Foods and Biosystems: Models for Predicting Growth and Inactivation.........................................................................9 Advanced Signal Processing: Theory and Implementation for Sonar, Radar, and Non-Invasive Medical Diagnostic Systems, Second Edition...................................................37 Advanced Textiles for Wound Care...................................37 Advances in Chromatographic Techniques for Therapeutic Drug Monitoring..........................................63

Biomedical Imaging in Experimental Neuroscience...........49 Biomedical Nanotechnology.............................................58 Biomedical Photonics Handbook......................................45 Biomedical Technology and Devices Handbook................45

Bayesian Disease Mapping: Hierarchical Modeling in Spatial Epidemiology........................................................80

Biomimetics: Biologically Inspired Technologies...............45

Bayesian Modeling in Bioinformatics................................70

Biomolecular EPR Spectroscopy.......................................55

Bioactive Natural Products: Detection, Isolation, and Structural Determination, Second Edition........................68

Bionanotechnology: Global Prospects...............................59

Bioactive Peptides..............................................................68

Biopharmaceuticals in Plants: Toward the Next Century of Medicine.........................................................62

Bioactive Peptides: Applications for Improving Nutrition and Health........................................................................23

Biosignal and Medical Image Processing, Second Edition..................................................................49

Biocatalysis and Agricultural Biotechnology......................53

Biostatistics: A Computing Approach...............................75

Advances in Chromatography, Volume 47........................55

Bioceramics and Their Clinical Applications.....................37

Biotechnology in Functional Foods and Nutraceuticals.....23

Advances in Chromatography: Volume 48........................55

Biochemical Applications of Nonlinear Optical Spectroscopy.....................................................................33

Biotechnology: A Comprehensive Training Guide for the Biotechnology Industry.....................................................53

Biodefense: Research Methodology and Animal Models................................................................................6

Bone Repair Biomaterials..................................................39

Advances in Food Biochemistry........................................33 Advances in the Neuroscience of Addiction.......................14 Advances in Vagal Afferent Neurobiology.........................15 Algorithms in Bioinformatics: A Practical Introduction....70

Biofluid Dynamics: Principles and Selected Applications......................................................................44

Animal Clinical Chemistry: A Practical Handbook for Toxicologists and Biomedical Researchers, Second Edition....................................................................6

Bio-Implant Interface: Improving Biomaterials and Tissue Reactions.........................................................37

Animal Hematotoxicology: A Practical Guide for Toxicologists and Biomedical Researchers...........................6 Animal Lectins: A Functional View.....................................3 Animal Models of Cognitive Impairment..........................15 Anticancer Agents from Natural Products.........................64 Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition............................................64

Bioinformatics Basics: Applications in Biological Science and Medicine, Second Edition..........................................70

C Cancer Epigenetics............................................................13 Cancer Systems Biology....................................................71 Carbohydrate-Active Enzymes: Structure, Function and Applications........................................................................9

Bioinformatics: A Practical Approach................................71

Carotenoids: Physical, Chemical, and Biological Functions and Properties...................................................................34

Bioinformatics: High Performance Parallel Computer Architectures.....................................................................70

Case Studies in Physiology and Nutrition.........................23

Biological and Bioenvironmental Heat and Mass Transfer....................................................................44 Biological Computation....................................................71

Causal Inference................................................................80 Cell Culture Technology for Pharmaceutical and Cell-Based Therapies.........................................................62

Biological Data Mining.....................................................75

Cell Mechanics: From Single Scale-Based Models to Multiscale Modeling.........................................................81

Applied Biomedical Engineering Mechanics......................43

Biological Performance of Materials: Fundamentals of Biocompatibility, Fourth Edition......................................37

Cellular and Molecular Biology of Metals...........................3

Applied Biomedical Microbiology: A Biofilms Approach...........................................................9

Biological Sequence Analysis Using the SeqAn C++ Library......................................................................71

Chemical and Biological Properties of Food Allergens.........5

Applying Genomic and Proteomic Microarray Technology in Drug Discovery..........................................64

Biologically Inspired Textiles.............................................38

Approaches to the Conformational Analysis of Biopharmaceuticals...........................................................64

Biology of the NMDA Receptor.......................................15

Chemical Information Mining: Facilitating Literature-Based Discovery................................................64

Biomaterials and Devices for the Circulatory Systems.......38

Chemicals from Microalgae...............................................62

Biomaterials and Regenerative Medicine in Ophthalmology.................................................................38

Chemistry and Molecular Aspects of Drug Design and Action...............................................................................67

Application of Solution Protein Chemistry to Biotechnology...................................................................29

Asbestos: Risk Assessment, Epidemiology, and Health Effects...............................................................................31 Atlas of Functional Neuroanatomy, Second Edition..........15

Biology for Engineers........................................................44

Title Index

Cellular Response to Biomaterials.....................................39 Chemical Components of Tobacco and Tobacco Smoke...............................................................................32

Atlas of Human Central Nervous System Development, 5-Volume Set......................................................................4

Biomaterials and Tissue Engineering in Urology...............60

Chemistry for the Life Sciences, Second Edition...............34

Biomaterials Fabrication and Processing Handbook..........38

Atlas of Immunology, Third Edition...................................5

Chemistry of Peptide Synthesis.........................................34

Biomaterials for Treating Skin Loss...................................39

Autism: Oxidative Stress, Inflammation, and Immune Abnormalities....................................................................15

Biomaterials: A Nano Approach........................................38

Chemoarchitectonic Atlas of the Developing Mouse Brain........................................................................7

Automated EEG-Based Diagnosis of Neurological Disorders: Inventing the Future of Neurology...................15

Biomaterials: Principles and Applications..........................38

Chiral Recognition in the Gas Phase.................................52

Biomechanics in Ergonomics, Second Edition..................43

Chiral Separations by Capillary Electrophoresis................56

Automated Image Detection of Retinal Pathology.............49

Biomechanics of the Upper Limbs: Mechanics, Modelling and Musculoskeletal Injuries.............................................43

Chitin, Chitosan, Oligosaccharides and Their Derivatives: Biological Activities and Applications............34

Biomedical Composites.....................................................39

Circadian Physiology, Second Edition...............................16

Bacterial Resistance to Antimicrobials, Second Edition.......9

Biomedical Engineering Fundamentals.............................45

Basic Introduction to Bioelectromagnetics, Second Edition..................................................................44

Biomedical Engineering Handbook, Third Edition â&#x20AC;&#x201C; Three - Volume Set..................................45

Cleaning Validation Manual: A Comprehensive Guide for the Pharmaceutical and Biotechnology Industries.............61 Cleanroom Microbiology for the Non-Microbiologist......10

For more information and a complete list Clinical Embryology: A Color Atlas and Text......................4 Clinical Engineering.........................................................46 Clinical Procedures for Medical Technology Specialists.....46 Clinical Trials in Oncology, Second Edition......................78 Cluster Randomised Trials................................................79 Coarse-Graining of Condensed Phase and Biomolecular Systems.............................................................................52 Colloids in Biotechnology.................................................53

Epidemiology: Study Design and Data Analysis, Second Edition..................................................................80

Design and Use of Relational Databases in Chemistry......64

Epigenetics in Biology and Medicine.................................14

Design Controls for the Medical Device Industry.............40

Epilepsy: Mechanisms, Models, and Translational Perspectives.......................................................................17

Design of Biomedical Devices and Systems Second Edition..................................................................40 Design of Caspase Inhibitors as Potential Clinical Agents..................................................................34

Colloids in Drug Delivery.................................................63

Design of Experiments and Linear Regression in the Biological Sciences............................................................76

Color Atlas and Manual of Microscopy for Criminalists, Chemists, and Conservators..............................................56

Design of Experiments: An Introduction Based on Linear Models..............................................................................76

Combination Products: Regulatory Challenges and Successful Product Development.......................................46

Designing Usability into Medical Products.......................46

Title Index

Combinatorial Pattern Matching Algorithms in Computational Biology Using Perl and R.........................71 Computational Intelligence in Medical Imaging: Techniques and Applications.............................................49 Computational Neuroscience: Realistic Modeling for Experimentalists................................................................16 Computational Protein-Protein Interactions.....................29 Computational Proteomics: Protein Classification and Meta-Organization............................................................30 Computer Vision: From Surface to Objects......................50 Concise Guide to Intraoperative Monitoring....................46 Concussive Brain Trauma: Neurobehavioral Impairment & Maladaption, Second Edition....................16 Copper Amine Oxidases: Structures, Catalytic Mechanisms, and Role in Pathophysiology........................34 Correlated Frailty Models in Survival Analysis..................76 CRC Desk Reference for Nutrition, Second Edition.........24 CRC Desk Reference on Sports Nutrition.........................24 CRC Handbook of Chemistry and Physics, 91st Edition......................................................................61 CRC Handbook of Chemistry and Physics, CD-ROM, Version 2010..................................................61

Design and Analysis of Quality of Life Studies in Clinical Trials, Second Edition..........................................79

Cryptosporidium and Cryptosporidiosis, Second Edition..................................................................10

D Data Analysis Tools for DNA Microarrays Using R, Second Edition..................................................................71 Data and Safety Monitoring Committees in Clinical Trials....................................................................79 Defensive Mutualism in Microbial Symbiosis....................10 Degradation Rate of Bioresorbable Materials: Prediction and Evaluation.................................................39 Delivery and Controlled Release of Bioactives in Foods and Nutraceuticals..................................................24 Dental Biomaterials: Imaging, Testing and Modelling.......39 Design and Analysis of Bioavailability and Bioequivalence Studies, Third Edition BABE-Solution Bundle Version..................................................................75

Development and Uses of Biofortified Agricultural Products............................................................................53

Ergonomics for Rehabilitation Professionals......................46 Essentials of Biotechnology...............................................54 Essentials of Human Physiology for Pharmacy, Second Edition..................................................................69 Essentials of Law and Ethics for Pharmacy Technicians, Second Edition..................................................................70 Experimental Surgical Models in the Laboratory Rat..........7

Diagnostic Endoscopy.......................................................50

Fat Detection: Taste, Texture, and Post Ingestive Effects....17

Diagnostic Ultrasound: Imaging and Blood Flow Measurements...................................................................50

Fate of Pharmaceuticals in the Environment and in Water Treatment Systems..................................................61

Dictionary of Alkaloids, Second Edition with CD-ROM.........................................................................68

Female Brain, Second Edition...........................................17

Dictionary of Carbohydrates with CD-ROM...................35

Food Biotechnology, Second Edition................................54

Dictionary of Marine Natural Products with CD-ROM.........................................................................65

Food Composition and Nutrition Tables, 7th Edition.......24

Dictionary of Nutraceuticals and Functional Foods..........24 Dietary Modulation of Cell Signaling Pathways..................3 Differential Equations and Mathematical Biology, Second Edition..................................................................81 Digital Microfluidic Biochips: Design Automation and Optimization....................................................................53 DNA Arrays: Technologies and Experimental Strategies....16

FLIM Microscopy in Biology and Medicine.....................56

Food Constituents and Oral Health: Current Status and Future Prospects................................................................24 Food Lipids: Chemistry, Nutrition, and Biotechnology, Third Edition....................................................................25 Food Safety of Proteins in Agricultural Biotechnology......30 Foodborne Pathogens: Hazards, Risk Analysis and Control, Second Edition............................................10

DNA Damage Recognition.................................................3

Foot and Ankle Motion Analysis: Clinical Treatment and Technology.......................................................................44

DNA Methylation Microarrays: Experimental Design and Statistical Analysis.............................................................72

Forensic Epidemiology......................................................80

DNA Microarrays and Related Genomics Techniques: Design, Analysis, and Interpretation of Experiments.........72

Functional Foods: Principles and Technology....................25 Fundamental Food Microbiology, Fourth Edition.............10

Drug Delivery and Targeting: For Pharmacists and Pharmaceutical Scientists..................................................69

Fundamentals of Microfluidics and Lab on a Chip for Biological Analysis and Discovery ....................................54

Drug Device Combination Products: Delivery Technologies and Applications..........................................63

Fundamentals of MRI: An Interactive Learning Approach..........................................................................50

Drug Synergism and Dose-Effect Data Analysis................67

Fundamentals of Nanotechnology.....................................59

Dynamic Synapse: Molecular Methods in Ionotropic Receptor Biology...............................................................16

Fundamentals of QSARs for Metal Ions............................35

E Electron Transfer Proteins: A Computational Perspective........................................................................30 Emerging Protein Biotherapeutics.....................................30 Encyclopedia of Biotechnology in Agriculture and Food (Print Version)..........................................................53 Encyclopedia of Chromatography, Third Edition (Print Version)...................................................................56

Fungal Pathogenesis in Plants and Crops: Molecular Biology and Host Defense Mechanisms, Second Edition..................................................................10

G Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, Third Edition.....................................................3 Gene Expression Studies Using Affymetrix Microarrays.......................................................................72 Gene Profiles in Drug Design...........................................65

Encyclopedia of Supramolecular Chemistry......................35

Genetics and Randomness................................................72

Design and Analysis of Clinical Trials with Time-to-Event Endpoints.................................................79

Endocannabinoids: The Brain and Bodyâ&#x20AC;&#x2122;s Marijuana and Beyond......................................................16

Geomicrobiology, Fifth Edition........................................10

Design and Analysis of Experiments with Examples of SAS...............................................................76

Endocrine Disruption Modeling.......................................32 Engineering Genetic Circuits............................................13

Geriatric Nutrition............................................................25 Glycome Informatics: Methods and Applications..............72

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Human Brain During the Early First Trimester...................4

Handbook of Anatomical Models for Radiation Dosimetry.........................................................................47

Human Brain During the Second Trimester........................4

Human Brain During the Late First Trimester....................4

Introduction to Survival Analysis Using Stata, Second Edition..................................................................77 Ion-Pair Chromatography and Related Techniques...........57 Ion-Radical Organic Chemistry: Principles and Applications, Second Edition............................................35

Handbook of Assay Development in Drug Discovery.......65

Human Brain During the Third Trimester..........................4

Handbook of Capillary and Microchip Electrophoresis and Associated Microtechniques, Third Edition.......................56

Human Error in Medicine, Second Edition......................65

Handbook of Computational Molecular Biology..............72

Jet Fuel Toxicology............................................................32

Ibuprofen: A Critical Bibliographic Review, Second Edition..................................................................69

Handbook of Cryo-Preparation Methods for Electron Microscopy.......................................................................56 Handbook of Forensic Toxicology for Medical Examiners.........................................................................32 Handbook of Hidden Markov Models in Bioinformatics...................................................................73 Handbook of Human Immunology, Second Edition..........6 Handbook of Laboratory Animal Science, Second Edition: Animal Models, Volume II........................7 Handbook of Laboratory Animal Science, Second Edition: Animal Models, Volume III.......................7 Handbook of Laboratory Animal Science, Second Edition: Essential Principles and Practices, Volume I. 7 Handbook of Listeria monocytogenes...............................11 Handbook of Microbiological Media, Fourth Edition.......11

Human Variation: From the Laboratory to the Field...........5

Kinetic Modelling in Systems Biology...............................82

Illustrated Dictionary of Immunology, Third Edition.........6

Image Processing with MATLABÂŽ: Applications in Medicine and Biology.......................................................50 Implementing Quality in Laboratory Policies and Processes: Using Templates, Project Management, and Six Sigma...................................................................61 In Vivo Optical Imaging of Brain Function, Second Edition..................................................................17 Index Nominum: International Drug Directory, Nineteenth Edition...........................................................66 Infectious Diseases and Pathology of Reptiles: Color Atlas and Text............................................................7 Insect Physiology and Biochemistry, Second Edition.........35

Handbook of Near-Infrared Analysis, Third Edition.........57

Insect Symbiosis, Volume 2...............................................11

Handbook of New Technologies for Genetic Improvement of Legumes........................................................................54

Insect Symbiosis, Volume 3...............................................11

Handbook of Nutrition and Food, Second Edition...........25

Joint Replacement Technology..........................................40

Illustrated Dictionary of Biotechnology............................54

Handbook of Microbiological Quality Control in Pharmaceuticals and Medical Devices...............................67

Handbook of Nucleic Acid Purification............................14

Insect Symbiosis, Volume 1...............................................11

Instrumental Data for Drug Analysis, Third Edition â&#x20AC;&#x201C; Six- Volume Set.......................................32 Integrated Nervous System: A Systematic Diagnostic Approach..........................................................................17

Laboratory Animal Pocket Reference Series, Ten Volume Set...................................................................8 Laboratory Biosecurity Handbook....................................11 Laboratory Canine..............................................................8 Laboratory Cat....................................................................8 Laboratory Course in Biomaterials....................................40 Laboratory Guinea Pig........................................................8 Laboratory Hamster and Gerbil..........................................8 Laboratory Mouse...............................................................8 Laboratory Nonhuman Primate..........................................8 Laboratory Rabbit, Second Edition.....................................8 Laboratory Rat....................................................................8 Laboratory Small Ruminant................................................8 Laboratory Swine, Second Edition......................................8 Laboratory Xenopus sp.......................................................8

Handbook of Optical Sensing of Glucose in Biological Fluids and Tissues.............................................................57

Intelligent and Adaptive Systems in Medicine...................47

Lactic Acid Bacteria: Microbiological and Functional Aspects, Third Edition......................................................12

Intestinal Failure and Rehabilitation: A Clinical Guide.....26

Lipid Metabolism and Health...........................................27

Handbook of Pharmaceutical Controlled Release Technology.......................................................................63

Introduction to Biology and Biotechnology, Second Edition..................................................................54

Lipid-Mediated Signaling....................................................3

Handbook of Physics in Medicine and Biology.................52

Introduction to Biomaterials.............................................40

Handbook of Prebiotics....................................................25

Introduction to Cereal Grains: Properties, Processing and Nutritional Attributes.......................................................26

Handbook of Nutrition in the Aged, Fourth Edition........25

Handbook of Prebiotics and Probiotics Ingredients: Health Benefits and Food Applications.............................26 Handbook of Solubility Data for Pharmaceuticals............68

Introduction to Dynamical Systems for Biological Modeling..........................................................................82

Handbook of Spatial Statistics...........................................80

Introduction to Machine Learning and Bioinformatics.....73

Handbook of Statistics in Clinical Oncology, Second Edition..................................................................76

Introduction to Microscopy..............................................57

Handbook of Venoms and Toxins of Reptiles....................32 Handbook of Vitamins, Fourth Edition............................26 Herbal and Traditional Medicine: Molecular Aspects of Health...............................................................................26

Introduction to Molecular Biology, Genomics and Proteomics for Biomedical Engineers................................47 Introduction to Nutrition and Metabolism, Fourth Edition..................................................................26 Introduction to Peptides and Proteins...............................30

Hierarchical Modeling and Analysis for Spatial Data.........76

Introduction to Physics in Modern Medicine....................47

High-Throughput Analysis in the Pharmaceutical Industry............................................................................65

Introduction to Randomized Controlled Clinical Trials, Second Edition..................................................................79

High-Throughput Lead Optimization in Drug Discovery.................................................................65

Introduction to Stata for Health Researchers, Second Edition..................................................................77

Histologic Basis of Mouse Endocrine System Development: A Comparative Analysis......................................................7

Introduction to Statistical Methods for Clinical Trials.......79

Title Index

Lipoic Acid: Energy Production, Antioxidant Activity and Health Effects...................................................................35 Listeria, Listeriosis, and Food Safety, Third Edition..........12

M Macroporous Polymers: Production Properties and Biotechnological/Biomedical Applications........................40 Managing Pharmacy Practice: Principles, Strategies, and Systems.............................................................................70 Managing the Laboratory Animal Facility, Second Edition....................................................................9 Manual of Stroke Models in Rats......................................17 Mass Spectrometry of Nucleosides and Nucleic Acids.......57 Materials Science for Dentistry, Ninth Edition..................41 Mathematical and Experimental Modeling of Physical and Biological Processes.......................................82 Measurement and Detection of Radiation, Second Edition..................................................................57 Measurement, Instrumentation and Sensors Handbook.........................................................................58 Medical Biostatistics, Second Edition................................77

For more information and a complete list Medical Device R&D Handbook.....................................41 Medical Devices and Systems............................................41 Medical Image Analysis Methods......................................50 Medical Image Processing, Reconstruction and Restoration: Concepts and Methods.................................51 Medical Image Registration...............................................51 Medical Nanotechnology and Nanomedicine....................47 Medical Physics and Biomedical Engineering....................47 Medical Textiles 2007: Proceedings of the Fourth International Conference on Healthcare and Medical Textiles..............................................................................41 Medicinal Protein Engineering..........................................30 Medicine and Evolution: Current Applications, Future Prospects.............................................................................5

Title Index

Meta-analysis and Combining Information in Genetics and Genomics..........................................................................73

Motor Neurobiology of the Spinal Cord...........................19

Paramecium: Genetics and Epigenetics.............................14

Multiple Testing Problems in Pharmaceutical Statistics.....61

Parkinson’s Disease............................................................21

Multiscale Cancer Modeling.............................................82

Particulate Systems in Nano- and Biotechnologies............60

Pediatric Epilepsy Case Studies: From Infancy and Childhood through Adolescence.......................................21

Nano- and Biocomposites.................................................41

Pediatric Rehabilitation Engineering: From Disability to Possibility..........................................................................48

Nanotechnology 2010: Three-Volume Set.........................59 Nanotechnology 2010: Three-Volume Set on CD-ROM.........................................................................59 Nanotechnology 2010: Volume 1: Fabrication, Particles, Characterization, MEMs, Electronics and Photonics.........59 Nanotechnology 2010: Volume 2: Life Sciences, Medicine, Diagnostics, Bio Materials and Composites.......................59

Pharmaceutical and Medical Applications of Near-Infrared Spectroscopy...............................................58 Pharmaceutical Chemical Analysis: Methods for Identification and Limit Tests............................................66 Pharmaceutical Packaging Technology..............................62 Pharmacoeconomics: From Theory to Practice..................62

Nanotechnology 2010: Volume 3: Biofuels, Renewable Energy, Coatings and Compact Modeling.........................59

Photoacoustic Imaging and Spectroscopy..........................51

Nanotechnology and Tissue Engineering: The Scaffold.....60

Phytochemicals in Nutrition and Health...........................29

Metabolic Pathway Engineering Handbook: Fundamentals.. 55

Nanotechnology in Biology and Medicine: Methods, Devices, and Applications.................................................59

Phytochemicals: Aging and Health....................................28

Metabolic Pathway Engineering Handbook: Tools and Applications......................................................................55

Natural Fibers, Biopolymers, and Biocomposites..............41

Metabolic Pathway Engineering Handbook, Two-Volume Set................................................................55

Methods in Alcohol-Related Neuroscience Research.........18

Motor Cortex in Voluntary Movements: A Distributed System for Distributed Functions......................................19

Natural-Based Polymers for Biomedical Applications........42

Physiology of Fishes, Third Edition.....................................5

Phytochemicals: Mechanisms of Action............................28 Phytochemicals: Nutrient-Gene Interactions.....................28 Pictorial Atlas of Soil and Seed Fungi: Morphologies of Cultured Fungi and Key to Species, Third Edition............12

Methods in Chemosensory Research.................................18

Neural Plasticity in Adult Somatic Sensory-Motor Systems.....................................................19

Methods in Drug Abuse Research: Cellular and Circuit Level Analyses...................................................................18

Neural Prostheses for Restoration of Sensory and Motor Function...........................................................................19

Polar Microbiology: The Ecology, Biodiversity and Bioremediation Potential of Microorganisms in Extremely Cold Environments..........................................13

Methods in Insect Sensory Neuroscience...........................19

Neuroanatomical Basis of Clinical Neurology...................20

Polymeric Biomaterials, Second Edition............................42

Methods in Microarray Normalization..............................66

Neurobiology of Huntington’s Disease..............................20

Polymers in Drug Delivery................................................63

Methods in Pain Research.................................................18

Neurobiology of Olfaction................................................20

Polyolefin Fibres: Industrial and Medical Applications......42

Methods in Reproductive Aquaculture: Marine and Freshwater Species...............................................................5

Neuroengineering.............................................................20 Neuroproteomics..............................................................20

Polysaccharides: Structural Diversity and Functional Versatility, Second Edition................................................68

Methods of Behavior Analysis in Neuroscience, Second Edition..................................................................18

New Concepts in Cerebral Ischemia.................................20

Practical Approach to Medical Image Processing...............51

Microarray Innovations: Technology and Experimentation...............................................................73

Nicotinic Receptors in the Nervous System.......................21 Nucleic Acids in Innate Immunity......................................6

Practical Atlas for Bacterial Identification, Second Edition..................................................................13

Microarray Methods and Protocols...................................14

Nutrients and Epigenetics.................................................27

Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery...............66

Microbial Food Contamination, Second Edition..............33

Nutrition in Public Health: Principles, Policies, and Practice.......................................................................27

Practical Handbook of Biochemistry and Molecular Biology, Second Edition CD-ROM..................36

Nutrition, Physical Activity, and Health in Early Life, Second Edition..................................................................27

Practical Handbook of Microbiology, Second Edition.......13

Nutritional Concerns in Recreation, Exercise, and Sport..........................................................................27

Primate Audition: Ethology and Neurobiology.................21

Microbial Limit and Bioburden Tests: Validation Approaches and Global Requirements,Second Edition......12 Microbiology of Wounds..................................................12 MicroComputed Tomography: Methodology and Applications......................................................................51 Micronutrients and Brain Health......................................19 Micronutrients: Metabolic Tuning Prevention - Therapy.........................................................27 Mobile Telemedicine: A Computing and Networking Perspective........................................................................48

Practical Statistics for Medical Research............................77

Nutritional Management of Digestive Disorders...............28

Primate Visual System.......................................................21

Principles and Practice of Bioanalysis, Second Edition......36

Omega-3 Fatty Acids and the DHA Principle...................36 Optical Tweezers: Methods and Applications....................52

Principles of Biomechanics................................................44 Principles of Food Toxicology............................................33 Process Chemistry in the Pharmaceutical Industry............66

Modelling Survival Data in Medical Research, Second Edition..................................................................77

Optimization in Medicine and Biology.............................48 Optimizing Women’s Health through Nutrition...............28

Process Chemistry in the Pharmaceutical Industry, Volume 2: Challenges in an Ever Changing Climate.........66

Modern Neurosurgery: Clinical Translation of Neuroscience Advances.....................................................19

Organic Chemistry of Sugars............................................36

Protein Discovery Technologies.........................................31

Molecular Basis of Chromatographic Separation...............36 Molecular Detection of Foodborne Pathogens..................12 Monitoring of Respiration and Circulation.......................48

Orthopaedic Bone Cements..............................................42

Protein Engineering and Design........................................31

Osmotic and Ionic Regulation: Cells and Animals..............4

Proteins: Energy, Heat and Signal Flow.............................31

Oxidative Stress and Inflammatory Mechanisms in Obesity, Diabetes, and the Metabolic Syndrome...............28

Python for Bioinformatics.................................................73

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Quality Assurance and Quality Control in the Analytical Chemical Laboratory: A Practical Approach......................68 Quantitative Drug Design: A Critical Introduction, Second Edition..................................................................67

Structural Bioinformatics: An Algorithmic Approach........74 Structure and Function of Intrinsically Disordered Proteins...........................................................31 Superior Colliculus: New Approaches for Studying Sensorimotor Integration..................................................22

Systems Biology and Bioinformatics: A Computational Approach..........................................................................75

Randomization, Bootstrap and Monte Carlo Methods in Biology, Third Edition......................................................77

Rapid Detection and Characterization of Foodborne Pathogens by Molecular Techniques..................................13

Targeted Delivery of Small and Macromolecular Drugs....63

Regulation of Gene Expression by Small RNAs.................14

Textbook of Drug Design and Discovery, Fourth Edition..................................................................67 Textbook of Receptor Pharmacology, Third Edition..........69

Reversibility of Chronic Degenerative Disease and Hypersensitivity, Volume 1: Regulating Mechanisms........33

Therapeutic Peptides and Proteins: Formulation, Processing, and Delivery Systems, Second Edition............31

Sample Sizes for Clinical Trials..........................................80 Scaffolding In Tissue Engineering.....................................60 Science of Imaging, An Introduction, Second Edition......51 Seafood and Freshwater Toxins: Pharmacology, Physiology, and Detection, Second Edition.......................33 Semiconductor Radiation Detection Systems....................48 Sensors for Chemical and Biological Applications.............58 Shape Classification and Analysis: Theory and Practice, Second Edition..................................................................52

Third Histamine Receptor: Selective Ligands as Potential Therapeutic Agents in CNS Disorders..............................22 3-D Cell-Based Biosensors in Drug Discovery Programs: Microtissue Engineering for High Throughput Screening..........................................................................62 3D Fibrous Assemblies: Properties, Applications and Modelling of Three-Dimensional Textile Structures..........43 Tissue Engineering............................................................60 Tissue Engineering and Artificial Organs..........................60 Titanium: Modelling Microstructure, Properties and Applications......................................................................43

Shape Memory Alloys for Biomedical Applications...........43

Translational Medicine: Strategies and Statistical Methods............................................................................78

Signal Processing in Magnetic Resonance Spectroscopy with Biomedical Applications......................52

Translational Pain Research: From Mouse to Man.............22

Signaling by Toll-Like Receptors.........................................4 Signaling Mechanisms of Oxygen and Nitrogen Free Radicals.............................................................................36 Sleep: Circuits and Functions............................................21 Somatosensory System: Deciphering the Brainâ&#x20AC;&#x2122;s Own Body Image..............................................................22 Spatial Epidemiological Approaches in Disease Mapping and Analysis.......................................................81 Spinal Cord from Gestational Week 4 to the 4th Postnatal Month...........................................................4 Statistical Analysis for Decision Makers in Healthcare, Second Edition: Understanding and Evaluating Critical Information in Changing Times........................................78 Statistical Analysis of Medical Data Using SAS.................78 Statistical and Computational Pharmacogenomics............74

Traumatic Brain Injury: Methods for Clinical and Forensic Neuropsychiatric Assessment, Second Edition.....22 Traumatic Brain Injury: Rehabilitation, Treatment, and Case Management, Third Edition..............................22 Tunable Laser Applications, Second Edition......................48 Two-Dimensional Optical Spectroscopy...........................58

U Ultrasonics: Data, Equations and Their Practical Uses......49 Understanding Autism: From Basic Neuroscience to Treatment..........................................................................23 Using Artificial Intelligence in Chemistry and Biology: A Practical Guide..............................................................75 Using Mass Spectrometry for Drug Metabolism Studies, Second Edition..................................................................58

Statistical Physics of Biomolecules: An Introduction.........74

Statistical Thinking in Epidemiology................................81

Veterinary Clinical Epidemiology, Third Edition..............81

Statistics for Epidemiology................................................81

Vitamin Analysis for the Health and Food Sciences, Second Edition..................................................................29

Statistics in Human Genetics and Molecular Biology........74

Water-Insoluble Drug Formulation, Second Edition.........67

Testing Statistical Hypotheses of Equivalence and Noninferiority, Second Edition.........................................78

Reliable Design of Medical Devices, Second Edition.........42

Water and Life: The Unique Properties of H20.................37

Swine in the Laboratory: Surgery, Anesthesia, Imaging, and Experimental Techniques, Second Edition..........................9

R Programming for Bioinformatics...................................73

Regenerative Medicine and Biomaterials for the Repair of Connective Tissues............................................................42

W-Z

Title Index

Statistics of Medical Imaging.............................................74

Vitamin K in Health and Disease......................................29

Stochastic Modelling for Systems Biology.........................74

Vitamins In Foods: Analysis, Bioavailability, and Stability......................................................................29

For more information and a complete list A Abbott; A..........................................................................38 Abbott; Louise C.................................................................7 Adeli; Hojjat.....................................................................15 Afanas’ev; Igor B...............................................................36 Aga; Diana S.....................................................................61 Ahmed; Hafiz......................................................................3 Aislabie; Jackie..................................................................13 Akira; Shizuo.......................................................................6 Akoh; Casimir C...............................................................25 Allen; Matthew J.................................................................8

Author Index

Allison; David B................................................................72 Alstrup; Aage Kristian Olsen...............................................8 Altman; Douglas G...........................................................77 Altman; Joseph....................................................................4 Aluru; Srinivas..................................................................72 Alzate; Oscar.....................................................................20 Amador Kane; Suzanne.....................................................47 Ambrosio; L......................................................................39 Anand; S. C......................................................................41 Anderson; Stewart.............................................................75 Ankerst; Donna Pauler......................................................76 Aoki-Kinoshita; Kiyoko F..................................................72 Arap; Wadih......................................................................31 Archer; C..........................................................................42 Arnold; Renée J. G............................................................62 Arora; Himanshu..............................................................54 Arslan; Orhan...................................................................20 Ashley; Mark J..................................................................22

Ashtok; Anika...................................................................53 Asif; Erfan Syed.................................................................61 Asyali; Musa Hakan..........................................................50 Atala; Anthony..................................................................60 Atlas; Ronald M..........................................................11, 13 Atwood; Jerry L.................................................................35 Awad; Atif B.....................................................................23 Azevedo; Helena S.............................................................42

Banville; Debra L..............................................................64

Buchanan; Fraser...............................................................39

Barber; D. C.....................................................................47

Buckingham; John............................................................68

Bar-Cohen; Yoseph............................................................45

Buehler; Lukas K...............................................................70

Barrow; John D.................................................................37

Bulpitt; Andrew J..............................................................50

Bassi; Sebastian.................................................................73

Burkowski; Forbes J..........................................................74

Bauer; Jeffrey C.................................................................78

Burnham; Keith J..............................................................47

Bayer; Shirley A...................................................................4

Burns; Donald A...............................................................57

Beale; G. H.......................................................................14

Burns; Mark D..................................................................32

Beasley; T. Mark................................................................72

Bej; Asim K.......................................................................13 Belkic; Dzevad..................................................................52 Belkic; Karen.....................................................................52 Bell; Suzanne.....................................................................57 Bender; David A...............................................................26 Benedetti; Jacqueline.........................................................78 Bennett; B. Taylor...............................................................8 Benoiton; N. Leo..............................................................34 Berdanier; Carolyn D............................................23, 24, 24 Berdanier; Lynne...............................................................23 Berry; Donald A................................................................78 Berry; Elizabeth...........................................................50, 51 Berry; Scott M..................................................................78 Best; Serena M..................................................................39 Bhethanabotla; Venkat R...................................................58 Bhunia; Arun....................................................................10 Bidlack; Wayne R........................................................28, 29 Black; Jonathan.................................................................37 Black; R............................................................................38 Blackburn; Clive de W......................................................10 Blanco; Carlos...................................................................39 Blom; J. A.........................................................................48 Blunt; John W...................................................................65 Bogner; Marilyn Sue.........................................................65 Bollen; Peter J. A.................................................................8 Botana; Luis M.................................................................33 Bourtzis; Kostas.................................................................11 Bradford; Peter G..............................................................23

Bradley; Richard................................................................40

Bagchi; Debasis.................................................................23

Brauer; Fred......................................................................81

Baggaley; Keith H.............................................................68

Brayton; Cory.....................................................................8

Baird; Rosamund M..........................................................67

Bretz; Frank......................................................................61

Ball; George F. M..............................................................29

Bronzino, PhD; Joseph D.................................................20

Banerjee; Bhaskar..............................................................28

Bronzino; Joseph D...................................38, 41, 45, 46, 60

Banerjee; Sudipto..............................................................76

Brookes; Murray.................................................................4

Banga; Ajay K...................................................................31

Brown; B.H......................................................................47

Banks; H. T.......................................................................81

Brown; Peggy A.................................................................80

Banoub; Joseph H.............................................................57

Brown; Ted.......................................................................15

Banuelos; Gary S...............................................................53

Buccafusco; Jerry J......................................................15, 18

Braish; Tamim...................................................................66

Cabrita; Elsa........................................................................5 Cadenas; Enrique..........................................................3, 19 Carlberg; David M............................................................10 Carlin; Bradley P.........................................................76, 78 Cartwright; Hugh.............................................................75 Cavalier; Annie.................................................................56 Cazes; Jack........................................................................56 Cecchi; Teresa...................................................................57 Cesar, Jr.; Roberto Marcondes...........................................52 Chakrabarty; Krishnendu..................................................53 Chan; Ka-Wing................................................................81 Chang; Mark.....................................................................75 Chapin; John K.................................................................19 Chapman; Kevin...............................................................21 Chau; Tom........................................................................48 Chauhan; Abha.................................................................15 Chauhan; Ved...................................................................15 Chauvière; Arnaud ...........................................................81 Chen; Hui.........................................................................48 Chen; Jake Y......................................................................75 Chen; Taosheng................................................................66 Chirila; T. V......................................................................38 Cho; Minhaeng.................................................................58 Cho; Susan Sungsoo..........................................................26 Choi; Sang-Woon.............................................................27 Chow; Shein-Chung...................................................75, 78 Christensen; Douglas A.....................................................44 Christensen; Thomas A.....................................................18 Christian, Jr.; Donnell R...................................................61 Chu; Paul K......................................................................38 Ciurczak; Emil W........................................................57, 58 Claiborne; James B..............................................................5 Clark; Suzanne Jane..........................................................76 Claude; Verdier.................................................................81 Clegg; Robert M...............................................................56 Clemons; Donna J..............................................................8 Cleves; Mario....................................................................77 Clontz; Lucia....................................................................12 Cochran; Jennifer R..........................................................31 Cohen; Zvi........................................................................62

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Colegate; Steven M...........................................................68

Doetsch; Paul W..................................................................3

Fortman; Jeffrey D..............................................................8

Collett; David...................................................................77

Dong; Zigang......................................................................3

Freivalds; Andris................................................................43

Collins; Christine E..........................................................21

Donnenberg; Albert D........................................................6

Fries; Richard C..........................................................40, 42

Collins; Peter M................................................................35

Draghici; Sorin..................................................................71

Friso; Simonetta................................................................27

Connor; Anne N...............................................................47

Drilling; Stephanie............................................................61

Frostig; Ron......................................................................17

Cook; Thomas D..............................................................79

Driskell; Judy A.................................................................27

Fuentes; Montserrat..........................................................80

Cope; Timothy C..............................................................19

Drzal; Lawrence T.............................................................41

Fügedi; Péter.....................................................................36

Cosmatos; Dennis . ..........................................................78

Duarte; F. J........................................................................48

Furse; Cynthia...................................................................44

Costa; Luciano da Fontoura..............................................52

Dumitriu; Severian......................................................42, 68

Costaridou; Lena...............................................................50

Durney; Carl H.................................................................44

Cragg; Gordon M.............................................................64

Dutta; Joydeep..................................................................59

Cravatt; Benjamin F..........................................................30

Dwyer; Johanna................................................................25

Cree; Michael J.................................................................49

Garti; Nissim....................................................................24

Galeaev; Igor Yu................................................................40 Gaudioso; Jennifer............................................................11

Ebadi; Manuchair ............................................................21

Gaur; Rajesh K..................................................................14

Ebner; Ford F....................................................................19

Gelfand; Alan E..........................................................76, 80

Eckerman; Keith F.............................................................47

Gentleman; Robert...........................................................73

Edwards; Jode W...............................................................72

Gezan; Salvador Alejandro................................................76

Eggersdorfer; Manfred......................................................19

Gharibzadeh; Shahriar .....................................................75

Ehrlich; Henry Lutz..........................................................11

Ghazanfar; Asif A..............................................................21

Eichelberger; Christopher N.............................................75

Ghista; Dhanjoo N...........................................................43

Eitenmiller; Ronald R.......................................................29

Ghosh; Dilip K.................................................................23

Danneman; Peggy...............................................................8

Elisseeff; Jennifer...............................................................60

Ghosh; Samiran................................................................70

Darlington; Cynthia..........................................................17

Ellingsen; Jan Eirik............................................................37

Ghosh-Dastidar; Samanwoy..............................................15

Darvell; Brian W...............................................................41

Ellison; M.........................................................................38

Gibb; Alasdair J.................................................................69

Dasgupta; Amitava............................................................63

El-Shall; Hassan................................................................60

Gibson; Glenn R...............................................................25

Crowley; John.............................................................76, 78 Cruse; Julius M...............................................................5, 6 Cserháti; Tibor..................................................................36 Cullimore; D. Roy............................................................13 Curtis; Richard..................................................................39 Cutting; Keith...................................................................12

Datta; Ashim K.................................................................44

Elton; Sarah........................................................................5

Gilthorpe; Mark S.............................................................81

Datta; Sujay......................................................................73

Enache; M........................................................................35

Gogol-Döring; Andreas.....................................................71

David; Yadin.....................................................................46

Ensminger; Dale...............................................................49

Göhlmann; Hinrich..........................................................72

Davies; Audra J...........................................................28, 29

Eskin; N. A. Michael.........................................................24

Goldman; Emanuel...........................................................13

De Muth; James E.............................................................61

Esteller; Manel..................................................................14

Goldstein; Darlene R........................................................73

De Schutter; Erik..............................................................16

Evans; David H...............................................................4, 5

Gollery; Martin.................................................................73

Dean; D A........................................................................62

Evans; E R.........................................................................62

Gomes; Manuela E............................................................42

Deb; Sanjukta...................................................................42

Evans; G.O.........................................................................6

Gopalaswamy; Smita.........................................................46

Deisboeck; Thomas S........................................................81

Everitt; Brian S..................................................................78

Gopalaswamy; Venky........................................................46

DeMets; David L..............................................................79

Goryanin; Igor..................................................................81

Demin; Oleg.....................................................................81 Demirkaya; Omer.............................................................50 Denstedt; John..................................................................60 Denyer; Stephen P.............................................................67 Der; Geoff.........................................................................78 Devillers; James.................................................................32 Dey; Dipak K....................................................................70 Di Loreto; Veronica.............................................................7 Di Marzo; Vincenzo..........................................................16 Di Silvio; Lucy..................................................................39 Diggle; Peter.....................................................................80 DiLorenzo, MD, PhD, MBA; Daniel J.............................20 Dmitrienko; Alex..............................................................61 Dodson; Ronald F.............................................................31

Fachmann; W...................................................................24 Fairclough; Diane L..........................................................79 Fanun; Monzer............................................................53, 63 Fayer; Ronald....................................................................10 Feldman; Elaine B.............................................................25 Field; Garrett.......................................................................8 Field; Karl J.........................................................................8 Finney; John L..................................................................37 Finocchiaro; Terry.............................................................26 Fisher; John P....................................................................60 Floris; Giovanni................................................................34 Foreman; John C...............................................................69 Forgács; Esther..................................................................36

Gould; William.................................................................77 Gourlay; T........................................................................38 Granacher, Jr.; Robert P.....................................................22 Graslund; Astrid................................................................30 Green; Lorrence H............................................................13 Green; Sherril L...................................................................8 Green; Stephanie...............................................................78 Grewal; Iqbal S.................................................................30 Grigorenko; Elena V..........................................................16 Grinberg; Nelu..................................................................55 Gröber; Uwe.....................................................................27 Grushka; Eli......................................................................55 Guelcher; Scott A..............................................................40 Guerra; Rudy....................................................................73

Author Index

Crooke; Stanley T..............................................................64

Gadamasetti; Kumar G.....................................................66

For more information and a complete list Guo; M.............................................................................25 Gutierrez; Roberto............................................................77 Guttorp; Peter...................................................................80

Ichiye; Toshiko..................................................................30

Indrayan; Abhaya..............................................................77

Haas; Olivier C. L.............................................................47

Ishii; Ken J..........................................................................6

Hagen; Wilfred Raymond.................................................55 Haider; Syed Imtiaz....................................................53, 61 Hajnal; Joseph V................................................................51 Hall; I H...........................................................................62 Hall; William C................................................................22 Halliwell; Barry.................................................................26

Author Index

Hammar; Samuel P............................................................31 Hammond; Bruce G.........................................................30 Hansen; Axel K...................................................................8 Hardiman; Gary................................................................73 Harper; Charles.................................................................37 Harris; Gerald F................................................................44 Hassanien; Aboul Ella.......................................................49 Hau; Jann...........................................................................7 Hawkes; David J...............................................................51 Hayes; Richard J...............................................................79 Haynes; William M...........................................................61

Iniewski; Krzysztof............................................................48

Kruger; Lawrence..............................................................22 Kshirsagar; Tushar.............................................................65 Kubic; Thomas..................................................................56 Kucklick; Theodore R.......................................................41 Kuhn; Cynthia M.............................................................14

Kumar; Ashok...................................................................40

Jackson; Todd A..................................................................8

Kumar; T .S. Sampath.......................................................38

Jacobowitz; David M..........................................................7 Jacobson; Elliott..................................................................7 Jan; Jiri..............................................................................51 Jedrychowski; Lucjan..........................................................5 Jelinek; Herbert F..............................................................49 Jewell; Nicholas P..............................................................81 Jiang; Jianmin...................................................................49 Johansen; Torben..............................................................69 Johnson; Arthur T.............................................................44 Jones; D. S........................................................................81 Jones; Sarah.......................................................................68 Jouyban; Abolghasem........................................................68 Julious; Steven A...............................................................80 Juul; Svend........................................................................77

Kumar; Shrawan.........................................................43, 46

L La Regina; Marie C.............................................................8 Lacroix; Damien...............................................................39 Lafdi; Khalid.....................................................................41 Lai; Poh-Chin...................................................................81 Lamm; Ehud.....................................................................71 Land; Tiit..........................................................................30 Landen, Jr; W. O...............................................................29 Landers; James P................................................................56 Landrum; John T..............................................................34 Langel; ร lo.......................................................................30 Lau; Alan Kin-tak.............................................................41 Lau; Francis C...................................................................23 Laurencin; Cato................................................................60

Hedaya; Mohsen A............................................................69

Hefferon; Kathleen Laura..................................................62

Kaas; Jon H.......................................................................21

Lawson; Andrew B............................................................80

Heldman; Dennis R..........................................................53

Kaufman; Matthew.............................................................7

Lawson; John....................................................................76

Hendelman; Walter J..................................................15, 17

Kennedy; J. F.....................................................................41

le Coutre; Johannes...........................................................17

Hernan; Miguel A.............................................................80

Kern; Mark.......................................................................24

Lee; Eva K.........................................................................48

Hernandez; Maria A..........................................................69

Khudyakov; Yury E...........................................................30

Lee; J. Jack........................................................................78

Herrรกez; Paz........................................................................5

Kim; Se-Kwon...................................................................34

Lei; Tianhu.......................................................................74

Herson; Jay.......................................................................79

King; Paul H.....................................................................40

Leitner; David M..............................................................31

Hewett; Terry A..................................................................8

Kingston; David G. I........................................................64

Lepadatu; Costinel............................................................35

Hill; Derek L.G.................................................................51

Kirti; P. B..........................................................................54

Levin; Edward D.........................................................15, 21

Hillery; Anya M................................................................69

Kisaalita; William S...........................................................62

Levin; Robert E...........................................................13, 54

Hodges; Norman A...........................................................67

Kittler; Josef T...................................................................16

Levy; Daniel E..................................................................36

Hollinger; Jeffrey O...........................................................40

Kleinstreuer; Clement.......................................................44

Lewis; A............................................................................63

Lawford; P. V....................................................................47

Hornyak; Gabor L............................................................59

Koehler; Steven A..............................................................80

Lewis; Douglas S...............................................................28

Hose; D. R........................................................................47

Kokubo; Tadashi...............................................................37

Lewis; Kim..........................................................................9

Hou; Ching T...................................................................53

Konat; Gregory W...............................................................4

Lewis; Robert E...............................................................5, 6

Howl; John.......................................................................68

Konieczka; Piotr................................................................68

Li; Paul C.H.....................................................................54

Hu; Jinlian........................................................................43

Koob; George F.................................................................14

Lidbury; Brett A................................................................65

Hu; Wei-Shou...................................................................62

Korfmacher; Walter A.......................................................58

Light; Alan R....................................................................22

Hughes; Robert E.............................................................20

Koropatnick; D. James........................................................3

Lim; Gino J.......................................................................48

Humbel; Bruno M............................................................56

Kourounakis; P. N.............................................................67

Limbach; Patrick A...........................................................57

Humphreys; Peter.............................................................17

Kow; Yoke Wah...................................................................3

Lin; Min...........................................................................74

Hussain; Farzana...............................................................41

Kraut; Heinrich.................................................................24

Lin; Rick C. S...................................................................20

Huston; Ronald................................................................44

Kribs-Zaleta; Christopher.................................................81

Lin; Zhi-Qing...................................................................53

Krogsgaard-Larsen; Povl....................................................67

Linton; Steven D...............................................................34

Kruger; Lawrence..............................................................18

Liu; Dongyou.......................................................11, 12, 14 Liu; Jen-pei.......................................................................75

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Min; David B....................................................................25

Liu; Xuanyong..................................................................38

Minor; Lisa K....................................................................65

Liu; Yuan..........................................................................18

Miraftab; M......................................................................41

Lloyd; Andrew W..............................................................69

Misra; Manjusri................................................................41

Lo; Donald C....................................................................10

Mitra; Sushmita................................................................73

Lonardi; Stefano................................................................75

Moffatt; Robert J..............................................................27

Lovinger; David M............................................................18

Mohanty; Amar K.............................................................41

Lundblad; Roger L................................................29, 36, 64

Moldin; Steven O.............................................................23

Luppi; Pierre-Herve’..........................................................21

Molina, M.D.; D. K..........................................................32

Lynden-Bell; Ruth M........................................................37

Molloy; Justin...................................................................52

Lyngstadaas; S.Petter.........................................................37

Molyneux; Russell J...........................................................68

Mondovi; Bruno...............................................................34

Ma; Peter X.......................................................................60 Mackessy; Stephen P..........................................................32 Madsen; Ulf......................................................................67 Mahalingam; Suresh..........................................................65 Mahato; Ram I..................................................................63 Malinov; Savko.................................................................43 Mallick; Bani K.................................................................70 Malsch; Neelina H............................................................58 Manly; Bryan F.J. .............................................................77 Mano; João F.....................................................................42 Marchenko; Yulia..............................................................77 Marks; Richard M.............................................................44 Marques; Alexandra P........................................................42 Marth; Elmer H................................................................12 Martin; Brett J....................................................................8 Martin; Yvonne C.............................................................67

Montmayeur; Jean-Pierre..................................................17 Moore; James....................................................................45

O’Donnell; T J..................................................................64 O’Gorman; Maurice R.G....................................................6 O’Higgins; Paul..................................................................5 Ollis, Jr.; Robert J.............................................................32 Omaye; Stanley T..............................................................29 Onaivi; Emmanuel S.........................................................16 Ong; Choon Nam.............................................................26 Orgill; Denis.....................................................................39 Ouwehand; Arthur C........................................................12 Owusu-Apenten; Richard..................................................23 Ozturk; Sadettin...............................................................62

P,Q

Morley; John E..................................................................25

Pachouri; Suparna S..........................................................54

Morris; Keith....................................................................57

Packer; Lester......................................................................3

Morris; Max......................................................................76

Packer; Lester..................................................19, 26, 28, 35

Morris; Simon Conway.....................................................37

Padgett; Miles J.................................................................52

Moschovakis; Adonis K.....................................................22

Page; Grier P......................................................................72

Moss; Stephen J................................................................16

Paliyath; Gopinadhan........................................................54

Moudgil; Brij. M...............................................................60

Papanicolaou; Andrew C...................................................46

Moulton; Lawrence H.......................................................79

Paˇrízková; Jana..................................................................27

Moxon; Karen A...............................................................19

Park; Joon B......................................................................38

Muller; Peter.....................................................................78

Park; Kwan-Hwa.................................................................9

Munro; Murray H. G........................................................65

Park; Sheldon J..................................................................31

Murphy; Eric J....................................................................3

Parker; Rolland S..............................................................16

Myers; Chris J...................................................................13

Pasqualini; Renata.............................................................31

Matarese; Laura E.............................................................26

Nair; Lakshmi...................................................................60

Matchett; Christian C.......................................................32

Najarian; Kayvan...............................................................75

Matson; Robert S........................................................14, 64

Najarian; Siamak...............................................................75

Matthews; John N. S.........................................................79

Namiesnik; Jacek...............................................................68

Mattiasson; Bo..................................................................40

Nano Science & Technology Institute...............................59

Mayazaki; Shuichi.............................................................43

Narang; Ajit S...................................................................63

McClure; Peter J...............................................................10

Nation; James L................................................................35

McCormick; Donald B.....................................................26

Nelson; Randall J..............................................................22

McCorry; Laurie Kelly......................................................69

Neuman; Michael R..........................................................46

McGloin; David................................................................52

Neves; Nuno M................................................................42

Mead; Andrew..................................................................76

Newman; David J.............................................................64

Menini; Anna....................................................................20

Newman; Dianne K..........................................................11

Merolli; Antonio...............................................................39

Newman; Michael C.........................................................35

Meskin; Mark S..........................................................28, 29

Nicolelis; Miguel A. L.......................................................18

Michailidis; George...........................................................73

Niessen; Sherry.................................................................30

Michniak; Bozena B..........................................................45

Nikitin; Alexander Yu..........................................................7

Michotte; Yvette................................................................56

Northrop; Robert B..........................................................47

Mikos; Antonios G...........................................................60

Nussinov; Ruth.................................................................29

Mills, III; Terry.................................................................32

O’Brien; Tom....................................................................34

Moore; John J...................................................................59

Mascie-Taylor; C.G. Nicholas.............................................5

Miller; Thomas A..............................................................11

Author Index

Liu; Rong..........................................................................67

Patel; Mulchand S.............................................................35 Paulson; Daryl S..................................................................9 Peace; Karl E.....................................................................79 Pedersen; Ole....................................................................66 Peleg; Micha........................................................................9 Percival; Steven..................................................................12 Perfetti; Thomas A............................................................32 Periasamy; Ammasi...........................................................56 Perkins; Theodore.............................................................73 Peterson; Andrew M.........................................................70 Petraco; Nicholas...............................................................56 Petronis; Art......................................................................72 Pfeiffer; Ronald F..............................................................21 Planell; Joseph A...............................................................39 Plank; M. J........................................................................81 Pometto; Anthony.............................................................54 Prasad; K. Satya.................................................................54 Preer, Jr.; John R...............................................................14 Preziosi; Luigi....................................................................81 Püssa; Tõnu......................................................................33

For more information and a complete list R Rainsford; Kim D.............................................................69 Rajendran; S.....................................................................37 Rajendran; S.....................................................................41 Ralphs; J...........................................................................42 Ram; Manoj Kumar..........................................................58 Ramakrishna; Seeram........................................................38 Ramalingam; Murugan.....................................................38 Randolph; R. Keith...........................................................28 Rangayyan; Rangaraj M....................................................49 Rashidi; Hooman H..........................................................70

Author Index

Rathinavelu; Appu............................................................69 Ray; Bibek.........................................................................10 Rea; William J...................................................................33 Reddy; K. Patrap...............................................................54 Refinetti, Ph.D.; Roberto..................................................16 Reilly; Cavan.....................................................................74 Reinert; Knut....................................................................71 Reis; R.L...........................................................................42 Reisman; Stanley...............................................................45 Reisner; David E...............................................................59 Rekka; E.A........................................................................67 Revell; P.A.........................................................................40 Rho; Jong M.....................................................................17 Rho; Jong M.....................................................................21 Riehle; Alexa.....................................................................19 Rigalli; Alfredo....................................................................7 Ritchie; Gary E.................................................................58 Ritchie; Glenn David........................................................32

Ritter; Arthur B................................................................45 Roberfroid; Marcel B........................................................25 Roberson; James Conrad...................................................32 Roberts; Andrew D...........................................................68 Roberts; Timothy .............................................................49 Robins; James M...............................................................80 Robles; Vanesa.....................................................................5 Rockett; Bernard...............................................................34 Rodgman; Alan.................................................................32 Rosenberger; Thad A...........................................................3 Rossi; John J......................................................................14

Salyers; Abigail....................................................................9

Street; Laurence J..............................................................46

Sankar; Raman..................................................................17

Stromgaard; Kristian.........................................................67

Saxby; Graham..................................................................51

Stulen; Foster B.................................................................49

Schaefer; Gerald................................................................49

Suckow; Mark A.................................................................8

Schatzlein; Andreas G.......................................................63

Sugiura; Takayuki..............................................................16

Schmidt; Bertil..................................................................70

Sundberg; John P.................................................................7

Schreiber; Gideon.............................................................29

Sung; Wing-Kin................................................................70

Schroeder; Valerie................................................................8

Surh; Young-Joon................................................................3

Seidner; Douglas L............................................................26

Suttie; John W...................................................................26

Semmlow; John L.............................................................49

Suttie; John W...................................................................29

Serna-Saldivar; Sergio O....................................................26

Sutton; Raul......................................................................34

Sha; Wei............................................................................43

Swarbrick; James...............................................................69

Shah; Dinesh O................................................................60

Swearengen; James R...........................................................6

Sharp; Patrick E..................................................................8

Swindells; Peter G.............................................................34

Shaw; Jei-Fu......................................................................53

Swindle; M. Michael...........................................................9

Shetty; Kalidas..................................................................54

Swiss Pharmaceutical Society.............................................66

Shung; K. Kirk..................................................................50

Szabo; L谩szl贸 F..................................................................68

Sibold; Amber L..................................................................8

Siede; Wolfram....................................................................3 Sies; Helmut.....................................................................19 Sies; Helmut.....................................................................28 Sigmund; Wolfgang..........................................................60 Silverman; Jerald.................................................................9 Simon; Mathew J..............................................................32 Simon; Sidney A...............................................................18 Skinner; Christopher.........................................................17 Sleeman; B.D....................................................................81 Smallwood; R.H...............................................................47 Smith; Angela....................................................................78 Smith; Peter A...................................................................44 Smith; Ronald D...............................................................81 Smolke; Christina D.........................................................55 So; Fun-Mun....................................................................81 Soboyejo; Winston O........................................................38 Sobti; R. C........................................................................54 Souci; Siegfried W.............................................................24 Spark; Arlene.....................................................................27 Spehner; Daniele...............................................................56 Splinter; Robert.................................................................52 Stafford; Phillip.................................................................66 Stamatakos; Georgio S......................................................81

Taber; Harry.......................................................................9 Tallarida; Ronald J............................................................67 Talloen; Willem................................................................72 Tamhane; Ajit C...............................................................61 Tamir; Snait......................................................................24 Teixeira; Marie B...............................................................40 Templeton; Nancy Smyth...................................................3 Terril-Robb; Lizabeth A......................................................8 Thomas; David R..............................................................25 Thompson; Lilian U.........................................................28 Tibbals; H.F......................................................................59 Tibbals; Harry F................................................................47 Todres; Zory Vlad.............................................................35 Tollefsbol; Trygve..............................................................13 Tompa; Peter.....................................................................31 Torres; Monica S...............................................................10 Tran; H. T.........................................................................81 Tsoulfanidis; Nicholas.......................................................57 Tu; Yu-Kang......................................................................81 Tuchin; Valery V................................................................57 Turner; Dennis A..............................................................19 Tyler; Christopher W.........................................................50

Stamford; Bryant...............................................................27

Steed; Jonathan W.............................................................35

Uchegbu; Ijeoma F............................................................63

Steiger; Ezra......................................................................26

Ugbolue; S. C. O..............................................................42

Stergiopoulos; Stergios......................................................37

Ulijaszek; Stanley................................................................5

Stock; Stuart R..................................................................51

Undem; Bradley J..............................................................15

Sahoo; Prasanna K............................................................50

Strandberg; Kenneth M....................................................70

Unger; Ron.......................................................................71

Salerno; Reynolds M.........................................................11

Straub; John E...................................................................31

Rubenstein; John L. R.......................................................23 Rucker; Robert B..............................................................26 Ruvinsky; Anatoly.............................................................72 Ryser; Elliot T....................................................................12

Salminen; Seppo...............................................................12

o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m Vaadia; Eilon.....................................................................19 Vaidyanath; K...................................................................54 Valentine; David L............................................................36 Valentine; Raymond C......................................................36 Valiente; Gabriel...............................................................71 Van Bruggen; Nick............................................................49 Van Eeckhaut; Ann...........................................................56 Van Hoosier, Jr.; Gerald L...................................................7 VanDongen; Antonius M..................................................15 Vasta; Gerardo R.................................................................3 Venn; Richard F.................................................................36 Vidhyasekaran; P...............................................................10 Vo-Dinh; Tuan............................................................45, 59 Vohora; Divya...................................................................22 von Heijne; Gunnar..........................................................30 von Maltzahn; Wolf W......................................................46

Webster; John G...............................................................58 Weinreich; Daniel.............................................................15 Welham; Suzanne Jane .....................................................76 Wellek; Stefan...................................................................78 White, Jr.; James F.............................................................10 Wichers; Harry J.................................................................5 Wienke; Andreas...............................................................76 Wiklund; Michael E..........................................................46 Wilcox; Stephen B............................................................46 Wilkinson; Darren J..........................................................74 Wilson, Ph.D.; Charles L..................................................33 Wilson; Michael................................................................24 Wise; Donald L.................................................................63 Witten; Mark L.................................................................32 Wolinsky; Ira.....................................................................27 Woodward; Mark..............................................................80 Wu; Rongling....................................................................74

von Wright; Atte...............................................................12

Voth; Gregory A................................................................52

Xian; Wujing.....................................................................40

W Walker; John D.................................................................35 Wang; Edwin....................................................................71 Wang; Lihong...................................................................51 Wang; Perry G..................................................................65

Zalups; Rudolfs K...............................................................3 Zehnacker; Anne...............................................................52 Zeiger; Errol......................................................................32 Zempleni; Janos................................................................23 Zempleni; Janos................................................................26 Zeng; Haishan..................................................................50 Zietman; Anthony..............................................................4 Zorko; Matja탑...................................................................30 Zouridakis; George...........................................................45 Zouridakis; George...........................................................46 Zuckerman; Daniel M......................................................74

Xiao; Lihua.......................................................................10 Xiao; Yang.........................................................................48 Xu; Tao.............................................................................53 Xu; Xie George.................................................................47

Wang; Sun-Chong............................................................72

Yakovlev; Vladislav............................................................33

Wang-Fischer; Yanlin........................................................17

Yasukouchi; Akira...............................................................5

Ward; Wendy E.................................................................28

Ye; Lin...............................................................................29

Watanabe; Tsuneo.............................................................12

Ye; Shui Qing....................................................................71

Waterhouse; Barry D.........................................................18

Yildiz; Fatih.......................................................................33

Watson; Ronald Ross........................................................25

Yona; Golan......................................................................30

Watson; Timothy..............................................................39

Yoneyama; Takayuki..........................................................43

Wax; Richard G..................................................................9

Author Index

plc

CRC Press • Taylor & Francis • Chapman & Hall/CRC • Auerbach Publications • Productivity Press

Visit us online at

www.crcpress.com

In the Americas Sales Office - CRC Press 6000 Broken Sound Parkway, NW, Suite 300, Boca Raton, FL 33487, U.S.A. Within the Continental USA - Tel: 800-272-7737 • Fax: 800-374-3401 • orders@taylorandfrancis.com Outside the Continental USA - Tel: 561-994-0555 • Fax: 561-361-6018 • international.orders@taylorandfrancis.com

Senior Vice President of Sales

Dennis Weiss Tel: 561-998-2510 Fax: 561-998-2580 e-mail: dennis.weiss@taylorandfrancis.com

Customer Service

Sales Agents

Angela Williams Tel: 800-272-7737 ext. 6091 Fax: 800-374-3401 e-mail: angela.williams@taylorandfrancis.com

Michael Dulisse Tel: 561-998-2582 Fax: 561-361-6049 e-mail: michael.dulisse@taylorandfrancis.com

Academic Sales

Premium/Custom Sales

Retail Bookstores

Library/Medical Wholesalers

Subsidiary Rights Sales

Ryan Prior Tel: 561-998-2516 Fax: 561-361-6049 e-mail: ryan.prior@taylorandfrancis.com

Susie Carlisle Tel: 561-998-2538 Fax: 561-361-6049 e-mail: susie.carlisle@taylorandfrancis.com

Evelyn Elias Tel: 561-361-6010 Fax: 561-361-6049 e-mail: evelyn.elias@taylorandfrancis.com

Jennifer Strong Tel: 212-216-7851 Fax: 212-244-1563 e-mail: jennifer.strong@taylorandfrancis.com

Milton Park Sales Office - Taylor & Francis Group (Books Ltd) 2 Park Square, Milton Park, Abingdon, Oxon, OX14 4RN, UK

Group Sales Director

Academic Representatives (UK)

China Liaison Office

Customer Services

Christoph Chesher Tel: +44 (0) 20 7017 6194 Fax: +44 (0) 20 7017 6748 e-mail: christoph.chesher@tandf.co.uk

Tim Page Higher Education Sales Manager Mobile: 07824 690646 e-mail: tim.page@tandf.co.uk

Book orders should be addressed to the appropriate overseas agent or the Customer Service Department at Bookpoint:

International Sales Director

International Enquiries

Graham Crossley Tel: +44 (0) 20 7017 6048 Fax: +44 (0) 20 7017 6748 e-mail: graham.crossley@tandf.co.uk

Kate Pearce International Sales Support Manager (Books) Tel: +44 (0) 20 7017 6053 Fax: +44 (0) 20 7017 6748 e-mail: kate.pearce@tandf.co.uk

Yan Pei Manager Taylor & Francis Room 523 Resource Building No. 151 North Street Zhongguancun Beijing, China 100080 P.O. Box: 8762 Tel/Fax: +86 (10) 58876523 e-mail: yanpei@tandf.co.sg

Foreign Rights

Standing Orders

Head of UK Sales Nick Perry Tel: +44 (0) 20 7017 6132 Fax: +44 (0) 20 7017 6732 e-mail: nick.perry@tandf.co.uk

Corporate and Institutional Sales Alfred Lea Tel: +44 (0) 20 7017 6273 Fax: +44 (0) 20 7017 6732 e-mail: cis@tandf.co.uk

Latin American Sales

UK Sales Support Executive Judith Cavell Tel: +44 (0) 20 7017 6191 Fax: +44 (0) 20 7017 6732 e-mail: judith.cavell@tandf.co.uk

Central and South America and Mexico Michael Dulisse Sales Office, Boca Raton, FL Taylor & Francis 6000 Broken Sound Parkway, NW, Suite 300, Boca Raton, FL 33487, USA Tel: 561-998-2582 Fax: 561-361-6049 e-mail: michael.dulisse@taylorandfrancis.com Ethan E. Atkin Cranbury International LLC 7 Clarendon Ave, Suite 2 Montpelier, VT 05602, USA Tel: +1 802 223 6565 Fax: +1 802 223 6824 e-mail: eatkin@cranburyinternational.com

European and Japanese Enquiries Lucy Astone International Sales Support Coordinator Tel: +44 (0) 20 7017 6149 Fax: +44 (0) 20 7017 6748 e-mail: lucy.astone@tandf.co.uk

South Asian, Middle Eastern and African Enquiries

Adele Parker e-mail: adele.parker@tandf.co.uk

Exhibitions Katie Gilbert Exhibitions Manager Tel: 020 7017 6310 e-mail: katie.gilbert@tandf.co.uk

Taylor & Francis Bookpoint 130 Milton Park, Abingdon, Oxon OX14 4SB Tel: +44 (0) 1235 400 524 Fax: +44 (0) 1235 400 525 e-mail (UK): uktrade@tandf.co.uk e-mail (international): international@tandf.co.uk If you would like to receive books on our improved preselective standing order system, or if you would like to have further information about this service, please contact your area manager or Customer Services Department.

Reanna Young International Sales Support Coordinator Tel: +44 (0) 20 7017 6114 Fax: +44 (0) 20 7017 6748 e-mail: reanna.young@tandf.co.uk

Caribbean and The West Indies

New Zealand

Middle East and North Africa

Jasmina Basic Area Sales Manager Milton Park Sales Office Tel: +44 (0) 20 7017 6187 Fax: +44 (0) 20 7017 6748 e-mail: jasmina.basic@tandf.co.uk

Macmillan Publishers NZ Ltd Victoria Johnson 6 Ride Way, Albany, Auckland, NZ Tel: +64 9414 0350 Fax: +64 9414 0357 e-mail: vicki@macmillan.co.nz

Australasia

Australia and New Zealand

Jasmina Basic Area Sales Manager – Middle East and Africa Milton Park Sales Office Tel: +44 (0) 20 7017 6187 Fax: +44 (0) 20 7017 6748 e-mail: jasmina.basic@tandf.co.uk Zoe Kaviani IPS (Middle East) Ltd P.O. Box 27533 Dubai, UAE Tel: +971 4 282 8801 Fax: +971 4 282 8804 e-mail: itpme@emirates.net.ae Website: http://www.ipsme.com

Kate Pearce Milton Park Sales Office Tel: +44 (0) 20 7017 6053 Fax: +44 (0) 20 7017 6748 e-mail: kate.pearce@tandf.co.uk

Australia Palgrave Macmillan Level 1, 15-19 Claremont Street, South Yarra Melbourne, Vic 3141, Australia Tel: +61 3 9825 1111 Fax: +61 3 9825 1010 e-mail: palgrave@macmillan.com.au www.palgravemacmillan.com.au

CRC Press and Marcel Dekker only Libraries may wish to order from their local bookseller, Palgrave Macmillan or DA Information Services Pty Ltd 648 Whitehorse Road, Mitcham Victoria, Australia Tel: +61 3 9210 7804 Fax: +61 3 9210 7788 www.dadirect.com.au

Australia Europa Publications (non-exclusive) James Bennett 3 Narabang Way, Belrose, NSW 2085 Australia Tel: +02 9986 7064 Fax: +02 9986 7030 www.bennett.com.au

Rest of Africa Jasmina Basic Area Sales Manager – Middle East and Africa Milton Park Sales Office

Korea

Chinke Ojiji Publishers Support Services Ltd Plot 2 Adewunmi Estate Oregun Road (Near First Bank Oregun) PO Box 9270, Ikeja, Lagos State Tel: +234 1 774 1073 Fax: +234 1 493 0419 e-mail: chinkeojiji@yahoo.co.uk

Se-Yung Jun ICK (Information & Culture Korea) 473-19 Seokyo-dong, Mapo-ku Seoul, Korea 121-842 Tel: +82 2 3141-4791 Fax: +82 2 3141-7733 e-mail: cs.ick@ick.co.kr

Botswana

For all Taylor & Francis Group imprints please order from our Singapore Sales Office Singapore Sales Office Taylor & Francis Asia Pacific 240 MacPherson Road #08-01 Pines Industrial Building Singapore 348574 Tel: +65 6741 5166 Fax: +65 6742 9356 e-mail: sales@tandf.com.sg

Arthur Oageng Book Promotions/Horizon Books Botswana Gaborone International Finance Park Plot 113-114, Unit 33, Kgale Mews 2, Suite 3 Gaborone, Botswana Tel: +267 393 1194 Fax: +267 392 4908 e-mail: arthur.oageng@online.co.bw

South Africa, Namibia, Lesotho and Swaziland Michelle Symington Book Promotions Ltd BMD Office Park, 108 De Waal Road Diep River, 7800 Cape Town South Africa Tel: +27 21 707 5700 General Fax: +27 21 707 5795 Orders Fax: +27 21 707 5794 e-mail: msymingtom@bookpro.co.za

South Asia Ryan Cooper Area Sales Manager Milton Park Sales Office Tel: +44 (0) 20 7017 6113 Fax: +44 (0) 20 7017 6748 e-mail: ryan.cooper@tandf.co.uk

India Taylor & Francis Books India Pvt Ltd. 912 Tolstoy House 15-17, Tolstoy Marg New Delhi 110 001 Tel: +91 (0) 11 2371 2131 +91 (0) 11 2335 1453 Fax: +91 (0) 11 2371 2132 e-mail: tandfindia@airtelbroadband.in

Pakistan M. Anwer Iqbal Book Bird Mian Chambers, 3 Temple Road PO Box 518, Lahore, Pakistan Tel: +92 42 636 7275 Fax: +92 42 636 1370 e-mail: bookbird@brain.net.pk

Sri Lanka Nirosha Saravanapavan e-mail: niroshas@sltnet.lk Mobile: 0094 714 750911

Japan Hans Van Ess Book Sales and Marketing Executive Taylor & Francis Group 7F Koshin Bldg. 2-23-4 Kanda-Jimbocho Chiyoda, Tokyo 101-0051, Japan Tel: +81 (0) 3 5848 7061 Mobile: +81 (0) 80 5426 3552 e-mail: hans.vaness@informa.com United Publishers Services Limited 1-32-5 Higashi-shinagawa Shinagawa-ku, Tokyo 140-0002 Tel: +81 (0) 3 5479 7251 Fax: +81 (0) 3 5479 7307 e-mail: info@ups.co.jp Editorial Office Takahiko Kaneko Edition Synapse Yamaguchi Bldg. 3F 2-8-5 Uchikanda Chiyoda-Ku, Tokyo 101 0047, Japan Tel: +81 (0) 3 5296 9186 Fax: +81 (0) 3 3252 1822 e-mail: edsynapse@nifty.ne.jp

East and Southeast Asia

Malaysia and Brunei

David Yeong General Manager Taylor & Francis Publishing Services Taylor & Francis Asia Pacific No. 23-2, Jalan PJS 8/18 Dataran Mentari 46150 Petaling Jaya Selangor Darul Ehsan Malaysia Tel: +60 (3) 5630 1361 Fax: +60 (3) 5630 1732 Mobile: +60 (0)16 331 9912 e-mail: david.yeong@tandf.com.sg

Singapore, Philippines and Indonesia

Francis Chua, Sales Manager Singapore Sales Office e-mail: francis.chua@tandf.com.sg

Vietnam

Jeffrey Lim, Books Sales Director Singapore Sales Office e-mail: jeffrey.lim@tandf.com.sg

Hong Kong

Taylor & Francis Asia Pacific Tel: +852 91796613 Jeffrey Lim, Books Sales Director e-mail: jeffrey.lim@tandf.com.sg Jolly Chan, Account Manager e-mail: jolly.chan@tandf.com.sg

Thailand

Taylor & Francis Asia Pacific Tel: +66 (2) 6427954-6 ext. 406 Fax: +66 (2) 6427677 Jeffrey Lim, Books Sales Director e-mail: jeffrey.lim@tandf.com.sg Nonglak Sawaithong, Sales Executive e-mail: s.nonglak@tandf.com.sg

Taiwan

Taylor & Francis Asia Pacific Tel: +886 (2) 2578 6106 ext.125 Fax: +886 (2) 2578 6507 Jeffrey Lim, Books Sales Director e-mail: jeffrey.lim@tandf.com.sg Raymond Hsu, Sales Executive e-mail: raymond.hsu@tandf.com.sg

China

Taylor & Francis Asia Pacific Room 903, Resource Building No.151 North Street Zhongguancun, Beijing, China 100080 Tel/Fax: +86 (10) 58876903 Jeffrey Lim, Books Sales Director e-mail: jeffrey.lim@tandf.com.sg Cynthia Ji, Sales & Marketing Executive e-mail: cynthia.ji@tandf.com.sg

Shanghai Region

Chris Ye, Senior Sales Executive Tel: +86 135 64618686 e-mail: chris.ye@tandf.com.sg

Israel and the Palestinian Territories Ryan Cooper Area Sales Manager Milton Park Sales Office Tel: +44 (0) 20 7017 6113 Fax: +44 (0) 20 7017 6748 e-mail: ryan.cooper@tandf.co.uk and Rodney Franklin Franklin’s International PO BOX 3772 7, Tel Aviv 61376, Israel Tel: +972 356 00724 Fax: +972 356 00479 e-mail: rodneyf@netvision.net.il

Europe Peter Havinga European Sales Manager A. Hofmanweg 5a, 2031 BH Haarlem The Netherlands Tel: +31 (0) 23 750 5730 Fax: +31 (0) 23 750 5701 Mobile: +31 (0) 6 515 69560 e-mail: peter.havinga@tandf.co.uk

Belgium, The Netherlands, France and Luxembourg Liza Walraven Sales Representative A. Hofmanweg 5a, 2031 BH Haarlem The Netherlands Tel: 0031 (0) 23 750 5731 Fax: 0031 (0) 23 750 5701 Mobile: 0031 (0) 6 238 49668 e-mail: liza.walraven@informa.com

England and Wales London (East, Northwest, North) and Eastern England Bob Davis Senior Area Representative Mobile: 07889 263 856 Fax: 01621 819 833 e-mail: bob.davis@tandf.co.uk

Southern England Daphne Edwards Area Representative Mobile: 07802 536 233 Tel: +44 (0) 20 7017 6259 e-mail: daphne.edwards@tandf.co.uk

Oxfordshire, West Midlands and South Wales John Blake Area Representative Mobile: 07889 263 857 Fax: 01242 228 691 e-mail: john.blake@tandf.co.uk

North and Northwest England Lucy Greaves Area Representative Mobile: 07860 633156 Fax: 01663 746682 e-mail: lucy.greaves@tandf.co.uk

London (EC, SE, SW, W and WC) Charlotte Westgate Area Representative Mobile: 07917 648040 e-mail: charlotte.westgate@tandf.co.uk

Greece

Scotland and North of England

Ryan Cooper Area Sales Manager Milton Park Sales Office Tel: +44 (0) 20 7017 6113 Fax: +44 (0) 20 7017 6748 e-mail: ryan.cooper@tandf.co.uk

Bob Fairbrother Area Representative Mobile: +44 (0) 7825 748476 E-mail: bob.fairbrother@tandf.co.uk Nick Pepper Area Representative Tel: 01434 250331 Mobile: 07825 748476

Nordic Countries Keith Gray Sales Representative Taylor & Francis Group c/o IBC Euroforum Blegdamsvej 104A, 2100 Copenhagen ø Denmark Tel: +45 4195 1428 Mobile: +45 6064 8041 e-mail: keith.gray@informa.com

Germany, Austria and Switzerland Eva Kneissl Area Sales Manager

(Maternity leave cover for Gabriela Mauch)

Mobile: +49 (0) 173905 9469 e-mail: eva.kneissl@informa.com

Spain, Portugal, and Italy Philip Veysey Area Sales Manager Príncipe de Vergara 109, 28002 Madrid, Spain Tel: +34 91 700 0688 Fax: +34 91 141 2304 Mobile: +34 68 777 3678 e-mail: philip.veysey@informa.com

Eastern Europe Marek Lewinson (Humanities and Social Sciences) Bohaterewicza 3/45 03-982 Warsaw, Poland Tel/fax: +48 (0) 22 6714819 Mobile: +48 (0) 602 707 037 e-mail: mlewinso@it.com.pl Radek Janousek (Science and Technology) Pod Nouzovem 972/21 197 00 Prague, Czech Republic Tel: +42 (0) 28 658 49888 Mobile: +42 (0) 602294014 e-mail: radek@mareklewinson.com

Sales Agents

Nigeria

Ireland and Northern Ireland Conor Graham / Michael Darcy Brookside Publishing Services 2 Brookside, Dundrum Road, Dublin 14 Tel: 00 353 1 298 9937 Fax: 00 353 1 298 7912 e-mail: sales@brookside.ie

Library Supply Nigel Berkeley Library Supply and London Key Accounts Manager Mobile: 07795 968206 e-mail: nigel.berkeley@tandf.co.uk

Online Retailers Rod Abraham Assistant UK Sales Manager Mobile: 07860 380 814 Fax: 01372 273 744 e-mail: rod.abraham@tandf.co.uk

ORDER FORM 1

BILL TO Name_____________________________________________________________

Name_____________________________________________________________

Title______________________________________________________________

Organization________________________________________________________

Address___________________________________________________________

City________________________________State/Province___________________

Country__________________________ Zip/Postal Code____________________

Daytime Phone (

)_____________________ Fax ( (Required to Process Order)

)__________________

e-Mail Address______________________________________________________

Order Form 96

SHIP TO (Fill in only if different than box 1)

)_____________________ Fax (

)__________________

e-Mail Address______________________________________________________

Please send me the following: ISBN NO.

QUANTITY

TITLE

PRICE EACH

TOTAL PRICE

Subtotal

Method of Payment

Tax o I’ve enclosed check #_____________________ payable to CRC Press LLC

Shipping Charges

o Bill My Company (Purchase Order Attached) o Please Charge to: o MasterCard

o VISA

Order Total

o American Express

CARD NO.

Exp. Date MO.

Sec. Code YR.

Signature _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ Phone Number _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ (Signature and Phone Number Required to Process Order)

SHIPPING AND HANDLING Region Delivery Time First Title Additional Title For expedited USA (continental) 3-5 days $4.99 $1.99 shipping, Alaska, Hawaii, Puerto Rico 4-5 days $14.99 $2.99 call your nearest Canada 3-7 days $7.99 $1.99 CRC PRESS Latin America varies by region $9.99 $2.99 office Rest of the World varies by region call for pricing

Ordering Locations Rest of the World: In the Americas: CRC PRESS / BOOKPOINT CRC PRESS

PO Box 409267 Atlanta, GA 30384-9267 Tel: 1-800-634-7064 Fax: 1-800-248-4724 From Outside the Continental U.S. Tel: 1-561-994-0555 Fax: 1-561-361-6018 e-mail: orders@taylorandfrancis.com

130 Milton Park Abingdon, Oxon, OX14 4SB, UK Tel: +44 (0) 1235 400 524 Fax: +44 (0) 1235 400 525 e-mail: (UK): uk.trade@tandf.co.uk (Int’l): international@tandf.co.uk

Corporate Offices CRC PRESS CRC PRESS UK

6000 Broken Sound Parkway, NW, Suite 300 Albert House, 4th floor Boca Raton, FL 33487, USA 1 - 4 Singer Street Tel: 1-800-272-7737 London EC2A 4BQ Fax: 1-800-374-3401 UK From Outside the Continental U.S. Tel: 44 (0) 20 7017 6000 Tel: 1-561-994-0555 Fax: 44 (0) 20 7017 6747 Fax: 1-561-361-6018 e-mail: enquiries@crcpress.com e-mail: orders@taylorandfrancis.com

www.crcpress.com

The following subject catalogs are available from CRC Press. You can view them online at the URLs listed or contact your local sales representative for copies.

Taylor & Francis Group

Agricultural and Life Sciences Catalog no. CATAGL • ISBN: 978-0-8493-3864-9 http://issuu.com/CRCPress/docs/annualcat_aglife

Biomedical Science and Engineering

Pioneers in Publishing

Catalog no. CATBMS • ISBN: 978-0-8493-3866-3 http://issuu.com/CRCPress/docs/annualcat_biomed

Business, Management, and Public Administration Catalog no. CATBMP • ISBN: 978-0-8493-9175-0 http://issuu.com/CRCPress/docs/annualcat_bus_pub_admin

Chemistry and Chemical Engineering Catalog no. CATSPC • ISBN: 978-0-8493-3867-0

http://issuu.com/CRCPress/docs/annualcat_chem

Civil and Mechanical Engineering Catalog no. CATMCE • ISBN: 978-0-8493-3880-9 http://issuu.com/CRCPress/docs/annualcat_civil_mech_eng

Computer Science and Information Technology Catalog no. CATITB • ISBN: 978-0-8493-3878-6 http://issuu.com/CRCPress/docs/annualcat_compsci_it

Electrical Engineering Catalog no. CATEEC • ISBN: 978-0-8493-3869-4 http://issuu.com/CRCPress/docs/annualcat_elec_eng

Environmental Science and Engineering

Catalog no. CATEVE • ISBN: 978-0-8493-3874-8 http://issuu.com/CRCPress/docs/annualcat_envsci

Food Science and Nutrition Catalog no. CATFSN • ISBN: 978-0-8493-3876-2 http://issuu.com/CRCPress/docs/annualcat_foodsci

Forensic Science, Law Enforcement, and Homeland Security Catalog no. CATFSC • ISBN: 978-0-8493-3877-9

INVITATION TO AUTHORS If you have an idea for a book or a manuscript in progress relevant to any scientific, technical, or business discipline, CRC Press is interested. Please contact:

John Lavender, Senior VP Publishing 561-994-0555 • john.lavender@taylorandfrancis.com

http://issuu.com/CRCPress/docs/annualcat_forensics

Human Factors and Ergonomics / Industrial Engineering and Manufacturing

To order, visit us online at

Catalog no. CATHFI • ISBN: 978-0-8493-3875-5 http://issuu.com/CRCPress/docs/annualcat_erg_indust_eng

Mathematics and Statistics Catalog no. CATMTS • ISBN: 978-0-8493-3879-3 http://issuu.com/CRCPress/docs/annualcat_math_stats

Nanoscience and Technology / CleanTech Catalog no. CATMSN • ISBN: 978-0-8493-3885-4 http://issuu.com/CRCPress/docs/annualcat_nano_clean_tech

Physics / Materials Science Catalog no. CATPHY • ISBN: 978-0-8493-9176-7 http://issuu.com/CRCPress/docs/annualcat_physics_matsci

• • • • •

All netBASE ebook Content on One Platform Pay-per-view Chapters Individual eBook Purchases Annual and Perpetual Subscription Options Available Improved Search and Functionality

Free Trials Available for Libraries