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Product Listings Biomedical Science Cell Biology................................................................................................................................................... 3 Developmental Biology................................................................................................................................. 4 Immunology................................................................................................................................................. 8 Lab Animal Science....................................................................................................................................... 9 Microbiology............................................................................................................................................... 12 Molecular Biology....................................................................................................................................... 18 Neuroscience.............................................................................................................................................. 19 Nutrition Science......................................................................................................................................... 24 Protein Science............................................................................................................................................ 30 Toxicology................................................................................................................................................... 31 Biomedical Engineering Biochemistry............................................................................................................................................... 33 Biomaterials & Medical Devices................................................................................................................... 37 Biomedical Engineering............................................................................................................................... 42 Biomedical Imaging.................................................................................................................................... 49 Biophysics................................................................................................................................................... 52 Biotechnology............................................................................................................................................. 54 Methods & Instrumentation........................................................................................................................ 58 Nanobiotechnology.................................................................................................................................... 60 Pharmaceutical Science General References...................................................................................................................................... 62 Biopharmaceuticals..................................................................................................................................... 63 Drug Delivery.............................................................................................................................................. 63 Drug Discovery & Development.................................................................................................................. 64 Pharmaceutical Science............................................................................................................................... 66 Pharmacology............................................................................................................................................. 67 Pharmacy.................................................................................................................................................... 68 Mathematics & Statistics in Biomedicine Bioinformatics............................................................................................................................................. 69 Biostatistics.................................................................................................................................................. 74 Clinical Trials............................................................................................................................................... 85 Epidemiology.............................................................................................................................................. 87 Mathematics for Biology & Medicine.......................................................................................................... 88 Title Index................................................................................................................................................... 91 Author Index............................................................................................................................................... 96 Sales Agents.............................................................................................................................................. 102 Order Form............................................................................................................................................... 104 Ordering Information / Call for Authors................................................................................ Inside Back Cover

Biomedical Science and Engineering Catalog - 2011

Table of Contents

For more information and a complete list of titles, visit us at www.crcpress.com

Apoptosis

Gene and Cell Therapy

Modern Insights into Disease from Molecules to Man

Therapeutic Mechanisms and Strategies, Third Edition

Edited by

Victor R. Preedy

Nancy Smyth Templeton

King’s College, London, UK

Gradalis Inc., Carrollton, Texas, USA

Apoptosis: Modern Insights into Disease from Molecules to Man covers Apoptosis from A to Z. Unlike other books that fail to target the key active elements, this book explores a wide range of topics – from various cancers, asthma, and multiple sclerosis, to alcohol liver disease, chronic back pain, and cardiovascular health. With 40 chapters written by reputable authorities, the book answers the field’s long-standing need for a one-stop comprehensive volume.

This latest edition of Gene and Cell Therapy provides comprehensive coverage of all aspects of the tools and state-of-the-art technologies currently available in this field. Written by international leaders, this edition features 12 additional chapters addressing new topics such as gene and cell therapies for diabetes and cardiovascular disease, relevant nanotechnologies, siRNA therapeutics, dendrimers, clinical trials, human embryonic stem cell research, tissue engineering, and novel polymers. All chapters in the text have been substantially updated and revised to reflect the latest information available in the field.

Available in eBook

Catalog no. 8768, ISBN: 978-0-8493-8768-5 October 2008, 8-1/2 x 11, 1120 pp. Suggested Price: $247.95 / £158.00

Cell Biology

Catalog no. N10280, ISBN: 978-1-57808-583-5 July 2010, 6-1/8 x 9-1/4, 650 pp. Suggested Price: $129.95 / £87.00

Available in eBook

Cellular and Molecular Biology of Metals Rudolfs K. Zalups Mercer University School of Medicine, Macon, Georgia, USA

James Koropatnick London Regional Cancer Center, Ontario, Canada

In recent years, there have been significant advancements in the understanding of the roles of certain metal ions in the conformational changes and function of cellular proteins. This volume explains the role of key biologically relevant divalent metal ions involved in the molecular and cellular biology of various target cell populations. Although it primarily focuses on homeostatic metals such as nickel, zinc, and chromium, the text also discusses a few environmentally relevant toxic divalent cations, including mercury, cadmium, and arsenic. Catalog no. 59971, ISBN: 978-1-4200-5997-7 May 2010, 7 x 10, 440 pp. Suggested Price: $199.95 / £127.00 Available in eBook

The Delivery of Regenerative Medicines and Their Impact on Healthcare Edited by

Inflammation, Life Style and Chronic Diseases The Silent Link Edited by

Bharat B. Aggarwal The University of Texas, Houston, USA

Sunil Krishnan Sushovan Guha Series: Oxidative Stress and Disease

This text discusses the role of inflammation on chronic diseases (including cancer, GI tract, metabolism and others diseases) and the effect of inflammations on lifestyle. It examines the links between the diseases and risk factors such as chronic infections, obesity, alcohol, tobacco, radiation, environmental pollutants, and high-calorie diets. It covers anti-inflammatory agents made by man and Mother Nature as potential therapeutics to the symptoms and presents research on how the suppression of proinflammatory pathways may provide opportunities for both prevention and treatment of chronic diseases. Catalog no. K11838, ISBN: 978-1-4398-3989-8 April 2011, 6-1/8 x 9-1/4, 576 pp. Suggested Price: $149.95 / £95.00 Available in eBook

Lipid Oxidation Pathways Volume Two

Catherine D. Prescott

Edited by

Biolatris Ltd., Cambridge, UK

Afaf Kamal-Eldin David Min

Dame Julia Polak Imperial College, London, UK

This book provides first-hand experience of the challenges and opportunities facing the delivery of regenerative medicines to patients. It highlights key issues beyond science and clinical translation, such as finance and business models, intellectual property and regulatory landscapes, as well as questions of how regenerative medicines will be evaluated for reimbursement. This book will become a pivotal reference to anyone within the healthcare sector interested in understanding and investing in the delivery of regenerative medicines to the benefit of patients. Catalog no. K11628, ISBN: 978-1-4398-3606-4 November 2010, 6-1/8 x 9-1/4, 400 pp. Suggested Price: $169.95 / £108.00

This volume complements Lipid Oxidation Pathways, Volume 1 by focusing on the oxidation kinetics and mechanisms governing the behavior of different molecular species involved in lipid oxidation reactions. It provides a more detailed review of the reactions of other lipid molecules than conventional polyunsaturated fatty acids. Catalog no. N10249, ISBN: 978-1-893997-56-1 January 2010, 6 x 9, 324 pp. Suggested Price: $198.00 / £127.00

Available in eBook

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Lipid-Mediated Signaling

Cell Biology / Developmental Biology

Edited by

What’s New About Crop Plants

Eric J. Murphy and Thad A. Rosenberger

Novel Discoveries of the 21st Century

University of North Dakota, Grand Forks, USA Series: Methods in Signal Transduction

U. S. Gupta

Lipid-Mediated Signaling provides a much needed examination of a decade’s worth of research tying pathologic disorders such as cancer and autoimmunity to aberrant or deregulated signal transduction processes. It considers particular cells, tissues, and organ systems, and discusses recent efforts to identify the various signaling proteins that govern their behavior. The book divides its material into five sections: fatty acid metabolism, eicosanoid formation, acyl hydrolase activity, phospholipids and nuclear signaling, and gene expression. It includes contributions from a number of pioneering experts in this emerging field.

Until recently, breeding efforts in mass produced food crops centered on high yield production while sacrificing flavor, taste, and other quality traits. Now, more emphasis is being placed on the enhancement of nutritional and medicinal properties of the food crops. Crops are today being looked from a health benefit perspective and even from an environmental standpoint. This volume looks at the use of crops for a myriad of purposes, including the prevention and/or mitigation of various diseases, vaccine and antigen production, biofuel production, and the suppression of weeds.

Catalog no. 8141, ISBN: 978-0-8493-8141-6 March 2010, 6-1/8 x 9-1/4, 452 pp. Suggested Price: $159.95 / £99.00

Catalog no. N10329, ISBN: 978-1-57808-699-3 January 2011, 6-1/8 x 9-1/4, 649 pp. Suggested Price: $179.95 / £114.00

Available in eBook

Stem Cell Labeling for Delivery and Tracking Using Non-invasive Imaging Edited by

Dara L. Kraitchman Johns Hopkins University, Maryland, USA

Joseph C. Wu Stanford University School of Medicine, California, USA Series in Medical Physics and Biomedical Engineering

This book provides a comprehensive overview of cell therapy imaging, ranging from the basic biology of cell therapeutic choices to the preclinical and clinical applications of cell therapy. The expert contributors emphasize the use of medical imaging for therapeutic delivery/targeting, cell tracking, and determining therapeutic efficacy. They discuss the different methodologies of stem cell labeling, the benefits of using multiple imaging modalities, and the application of the techniques to specific diseases in clinical trials. A CD-ROM includes images and movies. Catalog no. K10383, ISBN: 978-1-4398-0751-4 May 2011, 6-1/8 x 9-1/4, 288 pp. Suggested Price: $119.95 / £76.99

Retired Adj Professor, University of Georgia, Athens, USA

Airway Chemoreceptors in the Vertebrates Edited by

Giacomo Zaccone, Ernest Cutz, and Dirk Adriaensen The book provides a comprehensive and up-to-date account of the information available on the morphological, physiological, and evolutionary aspects of oxygen receptor neuroepithelial cells distributed within the epithelia of the airways in the vertebrates. Studies addressed to the chemoreceptor cell systems in the airways are of great importance for investigating their response to changes in the oxygen and carbon dioxide concentrations in the environment since the future of the planet earth is being threatened by global warming and climate change. Catalog no. N00105, ISBN: 978-1-57808-614-6 January 2009, 6 x 9, 464 pp. Suggested Price: $139.95 / £89.00 Available in eBook

Available in eBook

The Structure of Biological Membranes Third Edition

Five-Volume Set

Edited by

Shirley A. Bayer and Joseph Altman

Philip L. Yeagle

Indianapolis, Indiana, USA

The Structure of Biological Membranes, Second Edition focuses on lipids and the lipid bilayer, membrane protein structure and function, and includes a chapter on transport. It provides an integrated view of membranes as functioning units. This new edition incorporates recent advances in membrane protein structure, membrane rafts, and membrane fusion. The roles of cholesterol in the biology of cells, the structures of G-protein coupled receptors, membrane lipids as modulators of membrane-bound enzymes, and viral fusion mechanisms are presented and analyzed in depth. Catalog no. K10479, ISBN: 978-1-4398-0957-0 May 2011, 7 x 10, 552 pp. Suggested Price: $199.95 / £127.00 Available in eBook

Atlas of Human Central Nervous System Development

This award-winning series provides a complete record of the development of the human central nervous system from spinal cord gestation through the third trimester. The contents are organized by coronal, sagittal, and horizontal planes of sectioning, ensuring pictorial representation of nearly every structure in the developing brain. Each volume provides two-page spreads of highresolution black and white images on one side and ghost images on the other, with unabbreviated labels clearly identifying each structure. The final volume summarizes major events of CNS development and offers a theoretical account of the morphogenetic processes involved. Catalog no. 68008, ISBN: 978-1-4200-6800-9 July 2007 Suggested Price: $786.00 / £501.00

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Biological Clock in Fish Edited by

The Biology of Lungfishes

Ewa Kulczykowska

Edited by

Institute of Oceanology of the Polish Academy Sciences, Warsaw, Poland

Jorden Morup Jorgensen

Wlodzimierz Popek B.G. Kapoor

Jean Joss

University of Aarhus, Denmark

The Biology of Lungfishes presents an up-to-date collection of reviews on some of the most important aspects of the life of lungfishes. The book draws on contributions from well-known experts with long records of scientific work within their respective fields. The general natural history of the three genera of lungfishes, the fascinating fossil story, and modern ideas of lungfish phylogeny form the main part of the text. The book also covers the morphology and physiology of various organs.

Catalog no. N10269, ISBN: 978-1-57808-675-7 May 2010, 6 x 9, 280 pp. Suggested Price: $99.95 / £63.99

Catalog no. N10294, ISBN: 978-1-57808-431-9 November 2010, 6-1/8 x 9-1/4, 530 pp. Suggested Price: $139.95 / £89.00

Available in eBook

Reproduction of Amphibians

Comparative High Pressure Biology

Maria Oielska Series: Biological Systems in Vertebrates

This book deals with reproduction of Caecilians, Salamanders, Frogs, and Toads. The gonad structure and development, gametogenesis, urogenital connections, and reproductive tracts of males and females are treated individually. The text is illustrated with original schemes and photographs and focuses on anatomy, histology, cytology, and molecular mechanisms that regulate gametogenesis and reproductive cycles. Topics covered include: the origin of somatic and germ cells during formation of undifferentiated gonads, embryonic and postembryonic development, direct development, neoteny, and modifications of gametogenesis and meiosis in hybrids and polyploids (hybridogenesis and gynogenesis). Catalog no. N00197, ISBN: 978-1-57808-307-7 January 2009, 6 x 9, 436 pp. Suggested Price: $129.95 / £82.00

The Biology of Blennies Edited by

Developmental Biology

Macquarie University, Sydney, Australia

Circadian biological clocks exist in most organisms. Although biological clocks have been intensively studied in mammals over the past four decades, only recently have the tools needed to examine the molecular basis of circadian rhythms become available. This book reviews the state of knowledge in sufficient detail and presents the latest contributions to the field, showing fish provide a unique model of the circadian biological clock. The book explores the location, molecular basis, and other common questions about fish circadian clocks.

Edited by

Philippe Sebért One of the major reasons for the interest in studying high pressure is that this environmental factor also plays an important role in thermodynamics and consequently in biology. Pressure, from a biological perspective, has a bearing on all living creatures. The book presents a panoramic view of this subject from molecules to the overall organism via the cells and unicellular species, invertebrates and vertebrates, and ectotherms and endotherms. This book provides not only the more recent results in each of its chapters but also suggests new directions for research. Catalog no. N00107, ISBN: 978-1-57808-638-2 January 2010, 6 x 9, 575 pp. Suggested Price: $139.95 / £89.00 Available in eBook

Development of Non-Teleost Fishes

Robert A Patzner, Emanuel J. Gonçalves, and Philip A. Hastings

Edited by

Blennies are a diverse group of bony fishes found around the globe. As most blennies are small and somewhat difficult to identify, these fish did not occupy the interests of many ichthyologists and even fewer ecologists until recently. With nearly 900 species, blennies are important members of most coastal marine communities. This book should stimulate interest in blennies among a wider array of students, and marine biologists in general.

An up-to-date compilation of the development of non-teleost fishes has so far been unavailable. These fishes include the jawless fishes, the cartilaginous fishes, the forerunners of the teleostei: the cladistia, the chondrostei, the neopterygii, and, finally, the closest relations to the tetrapods: the lungfishes. Therefore, the present volume has been devoted to closing the gap with an up-to-date scientific review of the early life-history of these non-teleost fishes (agnathi excepted).

Catalog no. N00050, ISBN: 978-1-57808-439-5 January 2009, 6 x 9, 494 pp. Suggested Price: $139.95 / £89.00

Catalog no. N00059, ISBN: 978-1-57808-500-2 January 2009, 6 x 9, 309 pp. Suggested Price: $119.95 / £76.99

Available in eBook

Yvette W. Kunz, Carl A. Luer, and B.G. Kapoor

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Gonorynchiformes and Ostariophysan Relationships A Comprehensive Review (Series on: Teleostean Fish Biology)

Fish Defenses Vol. 1: Immunology

Edited by

Giacomo Zaccone, J. Meseguer, and B.G. Kapoor

Developmental Biology

The study of immunological fish defenses has advanced considerably in recent decades. This has been due to the key status of fish the field of immune system evolution and the rapid expansion of aquaculture over this period. Most of the chapters not only review the current advances on fish immune defenses, but also show perspective for future research. The book will be of interest to scientists involved in fish immunology, fisheries, and aquaculture as well as for students of fish biology. Catalog no. N00208, ISBN: 978-1-57808-327-5 January 2009, 6 x 9, 390 pp. Suggested Price: $119.95 / £76.99 Available in eBook

Terry Grande, Francisco José Poyato-Ariza, and Rui Diogo An understanding of gonorynchiform morphology and systematic inter- and intra-relationships has proven vital to a better understanding of the evolution of lower teleosts in general, and more specifically, of groups such as the clupeiforms (e.g., herrings and anchovies), and ostariophysans (e.g., carps, minnows, and catfishes). This book examines the current knowledge of gonorynchiform biology, including comparative osteology, myology, epibranchial morphology, and development. Phylogenetic interrelationships among gonorynchiform fishes are reexamined. Catalog no. N00014, ISBN: 978-1-57808-374-9 January 2010, 6 x 9, 600 pp. Suggested Price: $149.95 / £95.00 Available in eBook

Human Variation From the Laboratory to the Field

Fish Defenses Vol. 2: Pathogens, Parasites and Predators

Edited by

C.G. Nicholas Mascie-Taylor, Akira Yasukouchi, and Stanley Ulijaszek

Giacomo Zaccone, C. Perrière, and A. Mathis

Series: Society for the Study of Human Biology

Dramatic changes in the environment, including habitat degradation and climate change, have focused attention on how individuals and populations respond to a shifting biotic and abiotic landscape. Changes in water quality and temperature have direct and indirect effects on fishes. Defensive responses can occur at many levels, from cellular to behavioral actions. The authors in this volume provide a general view of the current state of knowledge of fish defenses with respect to pathogens, parasites, and predators, and point out gaps where further study is needed.

This work updates our understanding of human variation by employing both laboratory and field perspectives. Written by a team of scientists representing four continents, it reviews the way we examine and analyze human variation with special reference to genetics, growth, and development, and physiology. In describing the main factors influencing human variation, it delves into environmental plasticity, lifestyle, and heritability of characteristics. A significant part of the focus is on the methodology and analytical techniques, detailing field and laboratory approaches, and looking at how the two perspectives complement each other.

Catalog no. N00031, ISBN: 978-1-57808-407-4 January 2009, 6 x 9, 411 pp. Suggested Price: $129.95 / £82.00 Available in eBook

Catalog no. 84712, ISBN: 978-1-4200-8471-9 March 2010, 6-1/8 x 9-1/4, 317 pp. Suggested Price: $99.95 / £63.99 Available in eBook

Key Transitions in Animal Evolution Edited by

Fish Locomotion An Eco-ethological Perspective Edited by

Paolo Domenici and B.G. Kapoor Swimming is fundamental in a vast majority of fish species for avoiding predation, feeding, finding food, mating, migrating, and finding optimal physical environments. This treatise looks at fish swimming from the behavioral and ecological perspectives rather than from the more traditional biomechanics, ecomorphology, and physiological perspectives used in studies of fish swimming. The book is therefore largely integrative, and includes considerations related to fisheries, conservation, and evolution. It is aimed at students and researchers interested in fish swimming from any organismal background, be it biomechanics, ecomorphology, physiology, behavior or ecology. Catalog no. N00058, ISBN: 978-1-57808-448-7 January 2010, 6 x 9, 549 pp. Suggested Price: $139.95 / £89.00

Rob Desalle American Museum of Natural History, New York, New York, USA

Bernd Schierwater ITZ, Ecology and Evolution, TiHo Hannover, Germany

This challenging book summarizes the more recent results in phylogenetics and developmental biology that address the evolution of key innovations in metazoans. Divided into three sections, the first considers the phylogenetic issues involving this area of the tree of life and the elucidation of those relationships that continue to trouble taxonomists. The second section considers the developmental biology of metazoan evolution including the development of the nervous system, sensory organs, and physiological maturation. Part three focuses on the evolution of pattern and process in the Metazoa. Catalog no. N10322, ISBN: 978-1-57808-695-5 November 2010, 6-1/8 x 9-1/4, 340 pp. Suggested Price: $129.95 / £82.00 Available in eBook

Available in eBook For more information and a complete list of titles, visit us at www.crcpress.com

Textbook Comparative Anatomy, Evolution, Homologies and Development Rui Diogo The George Washington University, District of Columbia, USA

Virginia Abdala Universidad Nacional de Tucuman, Argentina

The Physiology of Fishes Third Edition Edited by

David H. Evans University of Florida, Gainesville, USA

James B. Claiborne Georgia Southern University, Statesboro, USA Series: Marine Biology

This book provides a detailed account of the comparative anatomy, development, homologies, and evolution of the head, neck, pectoral, and forelimb muscles of vertebrates. It includes hundreds of illustrations that show the homologies between the muscles of all the major extant vertebrate taxa. It supplies a list of more than a thousand synonyms used by other authors to designate these muscles. It reviews data obtained in the fields of evolutionary developmental biology, molecular biology, and embryology, explaining how this data can help in understanding the evolution and homologies of vertebrate muscles.

The Physiology of Fishes, Third Edition is not merely an update, but an entire reworking of the original using the latest research in microbiology. To satisfy that need for a fresh approach, the editors have employed a new set of expert contributors steeped in the very latest research. In addition to new chapters on gas transport, temperature physiology, and stress, as well as one dedicated to functional genomics, readers will discover that many of these new contributors approach their material with a contemporary molecular perspective.

Catalog no. N10284, ISBN: 978-1-57808-682-5 July 2010, 6 x 9.5, 500 pp. Suggested Price: $149.95 / £95.00

Catalog no. 2022, ISBN: 978-0-8493-2022-4 December 2005, 7 x 10, 616 pp. Suggested Price: $124.95 / £79.99

Developmental Biology

Muscles of Vertebrates

Available in eBook

Phenotypic Plasticity of Insects Mechanisms and Consequences Edited by

Douglas Whitman and T.N. Ananthakrishnan With phenotypic plasticity as a central organizing theme, this volume takes an integrative approach to explain how physical and biological environmental stimuli influence biochemical and physiological learning and developmental processes, so as to alter phenotype, which then influences performance, ecology, and subsequent evolution. Among a wealth of topics, the book covers endocrinology, allometry, mating, density-dependent prophylaxis, physiological adaptation, acclimation, homeostasis, heat-shock proteins, adaptive anti-predator behavior, and evolution of phenotypic plasticity. Catalog no. N00042, ISBN: 978-1-57808-423-4 January 2009, 6 x 9, 904 pp. Suggested Price: $139.95 / £89.00 Available in eBook

Reproductive Biology and Phylogeny of Chondrichthyes Sharks, Batoids, and Chimaeras, Volume 3 Edited by

William C. Hamlett Indiana University School of Medicine, Notre Dame, USA

Internal fertilization is universal in chondrichthyan fishes and, as such, requires a suite of biological activities, including behavioral, morphological, and physiological mechanisms, to ensure successful copulation and fertilization. This volume correlates available data and ideas concerning the development, reproductive morphology, function, and phylogeny of chondrichthyan fishes. Coverage includes oogenesis, spermatogenesis, gestation, regulation of reproductive tract function, sperm storage, nutrient provision, placentation, and phylogeny. New and exciting data is presented including the idea that yolk sac viviparity is the plesiomorphic state rather than oviparity. Catalog no. N10328, ISBN: 978-1-57808-314-5 March 2005, 6-1/8 x 9-1/4, 576 pp. Suggested Price: $169.95 / £108.00 Available in eBook

Photographic and Descriptive Musculoskeletal Atlas of Gorilla With Notes on the Attachments, Variations, Innervation, Synonymy and Weight of the Muscles Edited by

Rui Diogo, Bernard A. Wood, Josep M. Potau, Gaelle Bello, Juan F. Pastor, Felix J. dePaz, Eva M. Ferrero, and Mercedex Barbosa The Photographic and Descriptive Musculoskeletal Atlas of Gorilla includes numerous detailed, high-quality photographs of musculoskeletal structures from most anatomical regions of the body. It includes textual information about the attachments, innervations, and weights of the reported muscles. The book is based on the dissections of various fresh gorillas, as well as on an extensive review of the works published by other authors, thus providing an updated review of the anatomical variations within gorillas. Catalog no. N10305, ISBN: 978-1-57808-694-8 November 2010, 7 x 10, 120 pp. Suggested Price: $129.95 / £82.00

Reproductive Biology and Phylogeny of Fishes Vol. 8: Part B: Sperm Competion Hormones Edited by

Barrie G.M. Jamieson Reproductive Biology and Phylogeny of Fishes, Vol. 8, Part B deals with: testes, sperm, and sperm competition; endocrinology of reproduction; pheromones and reproduction; copulatory structures: taxonomic overview and the potential for sexual selection; sexual selection: signaling and courtship; adaptation and evolution of reproductive mode in copulating cottoid species; fertilization; sex determination; parental care; reproduction in relation to conservation and exploitation of marine fishes; Cryopreservation of Gametes; Embryogenesis and Development; and Molecular Genetics of Development. Catalog no. N00104, ISBN: 978-1-57808-581-1 January 2009, 6 x 9, 552 pp. Suggested Price: $139.95 / £89.00 Available in eBook

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Reproductive Biology and Phylogeny of Fishes Vol. 8A: Part A: Phylogeny Morphology Hormones Fertilization

Atlas of Immunology

Edited by

Julius M. Cruse and Robert E. Lewis

Developmental Biology / Immunology

Barrie G.M. Jamieson

Third Edition University of Mississippi Medical Center, Jackson, USA

It is perhaps because fishes live in a buoyant medium, whether it be fresh or sea water, that they show a diversity in body shapes that is unparalleled by other vertebrates. There is also a unique diversity in the modes of reproduction, whether by external or internal fertilization. These factors along with the morphology and fine structure of the reproductive system and its components, comprise the subject of the present volume. A large part of this book deals with the ultrastructure of spermatozoa, with some discussion of phylogenetic implications. Catalog no. N00103, ISBN: 978-1-57808-580-4 January 2009, 6 x 9, 802 pp. Suggested Price: $149.95 / £95.00

With more than 1300 figures, line drawings, and photographs, Atlas of Immunology clearly demonstrates that a picture is worth a thousand words. Each entry in this third edition has been revised to reflect recent advances in scientific knowledge based on current research. A new chapter, Immunophenotyping of Hematopoietic Malignancies, has been added and the History of Immunology chapter has been expanded, detailing pivotal research developments. The contents of the book range from photographs of field pioneers to illustrations of molecular structures of recently characterized cytokines, major histocompatibility complex molecules, immunoglobins, and molecules of related interest. Catalog no. K10141, ISBN: 978-1-4398-0268-7 April 2010, 8-1/2 x 11, 958 pp. Suggested Price: $119.95 / £76.99 Available in eBook

Chemical and Biological Properties of Food Allergens Edited by

Lucjan Jedrychowski

Sexuality in Fishes

Inst of Animal Reproduction & Food Research, Olsztyn, Poland

T.J. Pandian

Harry J. Wichers

Visiting Professor, Annamalai University, Tamil Nadu, India

Series: Chemical & Functional Properties of Food Components

The unprecedented level of diversity recorded among the clones of self-fertilizing gynogenetic unisexuals and self-fertilizing simultaneous hermaphrodites challenges current ideas on the predominant role of recombination in promoting evolution of biological diversity. Though limited to a few species, the existence of self-fertilizing and cyclical sex changing hermaphrodites remains a puzzle to many geneticists and endocrinologists. The causes for the sex changing mechanism pose many challenges to socio-ecologists and behavior specialists. This book is a synthesis of relevant and recent information on sexuality of fishes and points towards new directions of desired research.

Providing the clear-cut information necessary to conduct an effective allergen risk analysis, this book examines the chemical, analytical, technological, and medical aspects of food allergies and the growing problem of cross-contact contamination during product processing. With contributions from an international team of research specialists, the book explains the basic mechanisms of allergenic reactions in humans, the molecular background of these mechanisms, and the problems of food tolerance and intolerance. It also discusses the issues related to common treatments of food allergies and the narrow groups into which they are categorized.

Catalog no. N10287, ISBN: 978-1-57808-685-6 October 2010, 6 x 9 1/2, 190 pp. Suggested Price: $89.95 / £57.99

Catalog no. 5855X, ISBN: 978-1-4200-5855-0 September 2009, 6-1/8 x 9-1/4, 447 pp. Suggested Price: $164.95 / £105.00

Available in eBook

Vertebrates

Illustrated Dictionary of Immunology

Structures and Functions

Third Edition

S.M. Kisia University of Nairobi, Kenya Series: Biological Systems in Vertebrates

Julius M. Cruse and Robert E. Lewis University of Mississippi Medical Center, Jackson, USA

The book describes the diversity and features of various vertebrate groups, ranging from the oldest living fishes to the relatively modern mammals. The authors cover the structures of body systems including organs and tissues, including functions differences across various vertebrate groups. They also discuss the evolution of vertebrate groups from the earliest extinct ancestors to the living vertebrates as well as related groups that are now extinct. The book contains illustrations to clarify various issues and discussions of the features that enable vertebrates to adapt to aquatic and terrestrial environments they inhabit.

Designed for both immunologists and those scientists and students from other fields seeking a working understanding of immunology, this substantially revised and expanded new edition of the bestselling Illustrated Dictionary of Immunology strengthens its position as the leading general reference on the essential concepts of immunology. Written by two of the most respected scientists in the field, this edition features huge number of illustrations, while also adding additional computer-generated figures, line drawings, and photographs that illustrate critical aspects of immunology. The third edition also includes terms from various subspecialties, ranging from molecular immunology to transplantation.

Catalog no. N10263, ISBN: 978-1-57808-606-1 April 2010, 6 x 9, 530 pp., Soft Cover Suggested Price: $99.95 / £63.99

Catalog no. 7987, ISBN: 978-0-8493-7987-1 April 2009, 8-1/2 x 11, 816 pp. Suggested Price: $102.95 / £65.99

Available in eBook

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Immune-based Cancer Treatment The T Iymphocyte Response Edited by

Widener University, Chester, Pennsylvania, USA

Franck Genten, Eddy Terwinghe, and André Danguy

The culmination of 30 years of research and experience in T-cell-based cancer, this book highlights and evaluates new treatments that harness the power of the T cell to attack and kill all cancer cells in our bodies. It describes how the T cell immune system can be manipulated and redirected to kill resistant cancer cells by understanding and influencing the interaction of many different immune cells in the body. Citing current experimental trials, it examines the role and pathology of T-cells and suggests additional experimental approaches to the problem.

Although several studies treat histological aspects in relation to pathology, until now no recent synthesis on the normal histology of fish was available. Histology is the discipline of biology that involves the microscopic examination of thin stained tissue sections in order to study their structure and correlate it with function. Histology can detect signs of disease not easily recognized on gross examination and can therefore be of interest in fish health supervision. This volume presents a general reference guide providing an extensive set of histological images of fishes (about 40 species).

Catalog no. N10339, ISBN: 978-1-57808-703-7 February 2011, 6-1/8 x 9-1/4, 250 pp. Suggested Price: $129.95 / £82.00 Available in eBook

Immunology / Lab Animal Science

Atlas of Fish Histology

Michael A. Alexander

Catalog no. N00092, ISBN: 978-1-57808-544-6 January 2009, 6 x 9, 223 pp. Suggested Price: $149.95 / £95.00 Available in eBook

Making and Using Antibodies A Practical Handbook

The COST Manual of Laboratory Animal Care and Use Refinement, Reduction, and Research Edited by

Edited by

Bryan Howard

Gary C. Howard

Former Director of Animal Welfare, University of Sheffield, UK

Castro Valley, California, USA

Timo Nevalainen

Matthew R. Kaser Bell & Associates, San Francisco, California, USA

Written for professionals in the fields of biomedical research, Making and Using Antibodies: A Practical Handbook uses a cookbook approach to presenting methods for the production, characterization, and use of antibodies. The book focuses on specific aspects of antibodies and takes readers on a step-by-step process from antigen preparation to immunizations, adjuvants, screening, purification, storage, and applications. Introductory material accompanies each chapter, giving readers a better understanding of the methods and applications. It covers basic techniques including enzyme-linked immunosorbent assay (ELISA), Western blotting, immunohistochemistry, and flow cytometry. Catalog no. 3528, ISBN: 978-0-8493-3528-0 December 2006, 6-1/8 x 9-1/4, 408 pp., Soft Cover Suggested Price: $167.95 / £107.00 Available in eBook

University of Eastern Finland, Kuopio

Gemma Perretta Italian National Research Council, Italy

COST (European Cooperation in the field of Scientific and Technical Research) is an intergovernmental initiative in science and research intended to promote the coordination of nationally funded research at a European level. In laboratory animal science, four working groups were established to discuss the housing of animals, environmental needs, refinement of procedures, genetically modified animals, and cost-benefit analysis. Based on the activities of these working groups, this book provides the European best practices for individuals and institutions working with laboratory animals. The text also provides a guide for the ethical evaluation of experiments and procedures involving animals. Catalog no. K11184, ISBN: 978-1-4398-2492-4 October 2010, 7 x 10, 439 pp. Suggested Price: $89.95 / £57.99

A Practical Handbook for Toxicologists and Biomedical Researchers, Second Edition

A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis

Edited by

Animal Clinical Chemistry

Franz Joel Leong, Veronique Dartois, and Thomas Dick

G.O. Evans A. George Owen and Company, UK

Novartis Institute for Tropical Diseases, Singapore

Assembling information widely dispersed throughout the literature, the second edition of this work focuses on information of relevance to experimental toxicology as separate from human medicine. It presents background information on the selection and application of biochemical tests in safety assessment studies. In addition to chapters which discuss the assessment of toxicity in specific organs, such as the liver, kidney, and thyroid, the book also covers pre-analytical variables, regulatory requirements, and statistical approaches, while highlighting some of the major differences between humans and various laboratory animals.

This book is the first pictorial histopathology atlas with annotations on tuberculosis. The book’s drug discovery and animal model perspective makes in applicative rather than academic and presents the material in a highly readable format. Each section will cover the manifestations of induced or acquired pulmonary tuberculosis in one of six animal species (models) - human, non-human primate, rabbit, guinea pig, rat, and mouse. It provides low-, medium-, and high-power microscopy views of lung tissue in color to enhance the understanding of TB for newcomers and the senior tuberculosis researchers.

Catalog no. 80113, ISBN: 978-1-4200-8011-7 April 2009, 6-1/8 x 9-1/4, 368 pp. Suggested Price: $79.95 / £49.99

Catalog no. K11591, ISBN: 978-1-4398-3527-2 September 2010, 6-1/8 x 9-1/4, 236 pp., Soft Cover Suggested Price: $119.95 / £76.99

Also Available in Soft Cover

Available in eBook

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Histologic Basis of Mouse Endocrine System Development Experimental Surgical Models in the Laboratory Rat

A Comparative Analysis

Edited by

Alexander Yu. Nikitin

Alfredo Rigalli and Veronica Elina Di Loreto

Cornell University, Ithaca, New York, USA

Rosario National University, Rosario, Argentina

Lab Animal Science

Written for biomedical researchers, this manual on the surgery of the rat summarizes a series of techniques that have been applied at the Bone Biology Laboratories, School of Medicine, Rosario National University, Argentina. Stopping short of an exhaustive analysis of the techniques, the manual describes the basis of each surgical technique, the necessary materials including catheters, precautions to consider, the methodology to apply, and the possible results to be obtained. The descriptions of each technique appear with diagrams and pictures. Catalog no. 93266, ISBN: 978-1-4200-9326-1 May 2009, 7 x 10, 232 pp. Suggested Price: $139.95 / £89.00 Available in eBook

Handbook of Laboratory Animal Science Volume I, Third Edition: Essential Principles and Practices Edited by

University of Edinburgh, Scotland

John P. Sundberg The Jackson Laboratory, Bar Harbor, Maine, USA

As more than 3,000 mutant mice strains have been created through genetic manipulation, analysis of anatomic changes can be a challenge for even the best pathologist. This volume provides researchers with both a survey and a guide concerning use of the mutant mouse in histological studies of various glands. With full color throughout, this atlas illustrates the similarities and differences between the mouse endocrine system and that of other species including humans. It includes approximately 50 high-magnification color plates and a variety of sectioned embryos post-conception. Catalog no. 88181, ISBN: 978-1-4200-8818-2 October 2009, 7 x 10, 240 pp. Suggested Price: $149.95 / £95.00 Available in eBook

The IACUC Handbook Second Edition Edited by

Jerald Silverman University of Massachusetts Medical School, Worcester, USA

Jann Hau University of Copenhagen & Rigshhospitalet, Denmark

Steven J. Schapiro The University of Texas, Bastrop, USA

Matthew Kaufman

Now in its third edition, this comprehensive handbook explores the myriad issues surrounding the use of animals in scientific laboratories. Topics in Volume I include the history of animal research, ethical concerns, regulation and legislation, facilities and equipment, genetics, health monitoring, nutrient requirements and feeding schedules, statistical analysis, surgical and non-surgical techniques, and anesthesia. The book also explores alternatives to lab animal use with a discussion of the refinement, reduction, and replacement of animal uses in the life sciences. The book boasts an array of international contributors. Catalog no. 84550, ISBN: 978-1-4200-8455-9 December 2010, 7 x 10, 736 pp. Suggested Price: $149.95 / £95.00 Available in eBook

Handbook of Laboratory Animal Science Volume II, Third Edition: Animal Models

Mark A. Suckow University of Notre Dame, Indiana, USA

Sreekant Murthy Drexel University, Philadelphia, Pennsylvania, USA

The Institutional Animal Care and Use Committee has evolved as the premiere instrument of animal welfare supervision for institutions in the United States. The IACUC Handbook provides a foundation for those attempting to understand and implement the various responsibilities of this committee. This new edition features comprehensive updates for all pertinent federal laws, regulations, and policies. It incorporates revised suggestions from experienced professionals in the field to guide IACUC members on best-practice compliance. With concise, easy-to-find information, it remains the reference of choice for researchers and professionals. Catalog no. 4010, ISBN: 978-0-8493-4010-9 October 2006, 7 x 10, 680 pp. Suggested Price: $89.95 / £57.99

Infectious Diseases and Pathology of Reptiles

Edited by

Color Atlas and Text

Jann Hau

Edited by

University of Copenhagen & Rigshhospitalet, Denmark

Elliott Jacobson

Steven J. Schapiro

University of Florida College of Veterinary Medicine

The University of Texas, Bastrop, USA

This third edition of a bestselling handbook now has a truly international flavor. A chapter focuses on an important subdiscipline and can be read and used as stand-alone text, with only limited necessity to consult other chapters for information. This approach has resulted in slight overlaps in contents in some chapters, a small price to pay to make the book as reader friendly as possible. The handbook stresses the 3Rs; replacing live animals with alternative methods, reducing the number of animals used, and refining techniques to minimize the discomfort experienced by the animal participants. Catalog no. 84577, ISBN: 978-1-4200-8457-3 April 2011, 7 x 10, 480 pp. Suggested Price: $119.95 / £76.99 Available in eBook

Featuring 1,200 high-quality, color photos of normal anatomy and histology, as well as gross, light, and electron microscopic images of pathogens and diseases, this exceptionally comprehensive atlas provides definitive information on every known infectious disease affecting reptiles. Beginning with a thorough review of reptile biology, anatomy, and histology, leading authorities then addresses specific topics such as immunology, circulating inflammatory cells, necropsy techniques, pathogen identification and isolation, molecular diagnosis, and serodiagnostics. The atlas also catalogs specific pathologies due to viruses, bacteria, fungi, and parasites. Included are numerous never-before published electron microscope findings of reptile lesions. Catalog no. 2321, ISBN: 978-0-8493-2321-8 April 2007, 8-1/2 x 11, 736 pp. Suggested Price: $199.95 / £127.00 Available in eBook

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Laboratory Animal Pocket Reference Series Twelve-Volume Set

Jeffrey D. Fortman, B. Taylor Bennett and Lisa Halliday University of Illinois at Chicago, USA

A. Suckow

Terry A. Hewett

The Laboratory Animal Pocket Reference Series discusses procedures that ensure laboratory animals receive the best, most humane, and responsible care possible. The 12 volumes are compact and comb-bound to lay flat for use in the laboratory. The contents of each includes important biological features, husbandry, management, veterinary care, regulatory concerns, and commonly used and new procedures, as well as a section that includes an invaluable list of suppliers. Each book in the series can be purchased individually or as part of the set.

University of California, Davis, USA

Save on the Set!

Second Edition

Catalog no. 2562, ISBN: 978-0-8493-2562-5 September 2001, 6-1/8 x 9-1/4, 288 pp., Soft Cover Suggested Price: $57.95 / £36.99 Available in eBook

The Laboratory Rat

Catalog no. 2560, ISBN: 978-0-8493-2560-1 March 2000, 8-1/2 x 11, Suggested Price: $570.00 / £363.00

Patrick E. Sharp

The Laboratory Canine

Jason Vilano

Garrett Field, Eli Lilly and Company, Indianapolis, Indiana, USA Todd A. Jackson, Bristol-Myers Squibb, Evansville, Indiana, USA

Catalog no. K11462, ISBN: 978-1-4398-2986-8 May 2011, 6-1/8 x 9-1/4, 288 pp., Soft Cover Suggested Price: $59.95 / £38.99

Catalog no. 2893, ISBN: 978-0-8493-2893-0 October 2006, 6-1/8 x 9-1/4, 184 pp., Soft Cover Suggested Price: $57.95 / £36.99

The Laboratory Cat Brent J. Martin, Medical College of Ohio, Toledo, USA Catalog no. 2567, ISBN: 978-0-8493-2567-0 November 1997, 6-1/8 x 9-1/4, 160 pp., Soft Cover Suggested Price: $59.95 / £38.99

The Laboratory Guinea Pig Second Edition Lisabeth A. Terril and Donna Clemons Covance Laboratories Inc., Madison, Wisconsin, USA

Catalog no. K11598, ISBN: 978-1-4398-3556-2 April 2011, 6-1/8 x 9-1/4, 224 pp., Soft Cover Suggested Price: $59.95 / £38.99

The Laboratory Hamster and Gerbil Karl J. Field, Bristol Myers Veterinary Sciences, Flemington, New Jersey, USA Amber L. Sibold, Consultant, East Hanover, New Jersey, USA Catalog no. 2566, ISBN: 978-0-8493-2566-3 December 1998, 6-1/8 x 9-1/4, 168 pp., Soft Cover Suggested Price: $57.95 / £36.99

The Laboratory Mouse Mark A. Suckow, University of Notre Dame, Indiana, USA Peggy Danneman, The Jackson Laboratory, Bar Harbor, Maine, USA Cory Brayton, Johns Hopkins University, Baltimore, Maryland, USA Catalog no. 0322, ISBN: 978-0-8493-0322-7 December 2000, 6-1/8 x 9-1/4, 184 pp., Soft Cover Suggested Price: $57.95 / £36.99

National University of Singapore Penn State Hershey Medical Center, PA, USA

Available in eBook

The Laboratory Small Ruminant Matthew J. Allen, SUNY Health Science Center, Syracuse, New York, USA Gary L. Borkowski, Consultant, Saint Louis, Missouri, USA Catalog no. 2893, ISBN: 978-0-8493-2893-0 October 2006, 6-1/8 x 9-1/4, 184 pp., Soft Cover Suggested Price: $57.95 / £36.99

The Laboratory Swine Second Edition Peter J. A. Bollen University of Southern Denmark, Odense

Axel Kornerup Hansen University of Copenhagen, Frederiksberg, Denmark

Aage Kristian Olsen Alstrup Aarhus University Hospital, Aarhus, Denmark

Catalog no. K10783, ISBN: 978-1-4398-1528-1 February 2010, 6-1/8 x 9-1/4, 138 pp., Soft Cover Suggested Price: $59.95 / £38.99

The Laboratory Xenopus sp Sherril L. Green Stanford University, California, USA

Catalog no. 91093, ISBN: 978-1-4200-9109-0 December 2009, 6-1/8 x 9-1/4, 180 pp., Soft Cover Suggested Price: $59.95 / £38.99

The Laboratory Zebrafish Claudia Harper and Amgen Inc., Cambridge, Massachusetts, USA

Available in eBook

Christian Lawrence

The Laboratory Rabbit

Children’s Hospital Boston, Massachusetts, USA Series: Laboratory Animal Pocket Reference

Second Edition Mark A. Suckow and Valerie Schroeder, University of Notre Dame, Indiana, USA Catalog no. 91050, ISBN: 978-1-4200-9105-2 April 2010, 6-1/8 x 9-1/4, 148 pp., Soft Cover Suggested Price: $59.95 / £38.99

Lab Animal Science

Edited by Mark

The Laboratory Nonhuman Primate

Catalog no. K10378, ISBN: 978-1-4398-0743-9 December 2010, 6-1/8 x 9-1/4, 274 pp., Soft Cover Suggested Price: $59.95 / £38.99

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Laboratory Mouse and Laboratory Rat Procedural Techniques Manuals and DVDs John J. Bogdanske, Scott Hubbard-Van Stelle, Margaret Rankin-Riley, and Beth M. Schiffman

Lab Animal Science / Microbiology

University of Wisconsin, Madison, USA

This combination of manuals and DVDs provides much-needed training on the proper handling of mice and rats used in biomedical research. The DVDs include narrated video clips that demonstrate and describe each procedural technique. The manuals contain handouts with color illustrations and descriptive text for each technique, including the purpose and application of the procedure, recommended skills, and necessary supplies. The pair can be used as a training resource and refresher for lab animal veterinarians, veterinary technicians, animal care staff, trainers, and research investigators, as well as staff who work with mice and rats. Catalog no. K12298, ISBN: 978-1-4398-5050-3 December 2010, 6-1/8 x 9-1/4, 192 pp., Soft Cover Suggested Price: $108.00 / £68.99

Laboratory Mouse Procedural Techniques Manual and DVD

Second Edition Jerald Silverman University of Massachusetts Medical School, Worcester, USA

A launching pad to providing high-quality management of laboratory animal facilities in a financially sound manner, this guide enables a basic understanding of management and leadership concepts in laboratory animal science. While retaining the focus of its predecessor, this edition contains over 100 more pages of new and expanded material. It includes an entirely new chapter on leadership, a greatly expanded chapter on the management of human resources, a new appendix on productivity goals and measurements, and a revised appendix on how to calculate per diem rates. Catalog no. 55569, ISBN: 978-1-4200-5556-6 July 2008, 6-1/8 x 9-1/4, 328 pp. Suggested Price: $79.95 / £49.99 Available in eBook

Swine in the Laboratory

John J. Bogdanske, Scott Hubbard-Van Stelle, Margaret Rankin-Riley, and Beth M. Schiffman

Surgery, Anesthesia, Imaging, and Experimental Techniques, Second Edition

University of Wisconsin, Madison, USA

Edited by

Catalog no. K12294, ISBN: 978-1-4398-5042-8 December 2010, 6-1/8 x 9-1/4, 100 pp., Soft Cover Suggested Price: $59.95 / £38.99

M. Michael Swindle Medical University of South Carolina, Charleston, USA

University of Wisconsin, Madison, USA

To diminish the learning curve associated with using swine as models, this book provides practical technical information for the use of swine in biomedical research. It focuses on models produced by surgical and other invasive procedures, supplying the basic principles for performing experiments with an organ or system of interest. This edition contains never-before-published images, new chapters on toxicology and radiobiology, updated sections on anesthesia and perioperative care, and expanded details on anatomy and endoscopy. It also includes an accompanying DVD with 3-D, full-color images.

Catalog no. K12295, ISBN: 978-1-4398-5044-2 December 2010, 6-1/8 x 9-1/4, 92 pp., Soft Cover Suggested Price: $59.95 / £38.99

Catalog no. 9278, ISBN: 978-0-8493-9278-8 March 2007, 7 x 10, 496 pp. Suggested Price: $159.95 / £102.00

Laboratory Rat Procedural Techniques Manual and DVD John J. Bogdanske, Scott Hubbard-Van Stelle, Margaret Rankin-Riley, and Beth M. Schiffman

Managing the Laboratory Animal Facility

Available in eBook

Management of Laboratory Animal Care and Use Programs Edited by

Mark A. Suckow

Advances in Food Dehydration

University of Notre Dame, Indiana, USA

Edited by

Fred A. Douglas

Cristina Ratti

Purdue University, West Lafayette, Indiana, USA

Laval University, St-Foy, Quebec, Canada Series: Contemporary Food Engineering

Robert H. Weichbrod National Eye Institute, Maryland, USA

The management of biomedical research using animals has become increasingly complex due to new technology, increased regulatory oversight, and recognition of the need for animals free of disease and distress. Management of Laboratory Animals Care and Use Programs provides both factual and theoretical information drawn from the substantial experience of authors who are noted experts in the field. Laboratory animal management is a discipline that is likely to experience continued growth and an increase in complexity. This book presents the basic knowledge and information needed to meet typical professional challenges.

Advances in Food Dehydration provides a practical understanding of dehydration and the latest developments in the food industry, including improved dehydration methods, analytical techniques, and mathematical modeling. This book explains the structural and physic-chemical changes that food undergoes during dehydration and discusses ways to optimize natural resources. Nonconvectional heating sources such as microwaves, infrared, and radio frequency are described. The text also examines the impact of drying on nutraceutical compounds, the bases of rehydration of dry food particles and the stresses on microorganisms during drying and their stability during storage.

Catalog no. 2287, ISBN: 978-0-8493-2287-7 November 2001, 6-1/8 x 9-1/4, 408 pp. Suggested Price: $94.95 / £60.99

Catalog no. 52527, ISBN: 978-1-4200-5252-7 November 2008, 6-1/8 x 9-1/4, 467 pp. Suggested Price: $185.95 / £119.00

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Biosensors in Food Processing, Safety, and Quality Control

The Alga Dunaliella

Mehmet Mutlu

Ami Ben-Amotz, Jürgen E.W. Polle, and D.V. Subba Rao

Hacettepe University, Ankara, Turkey Series: Contemporary Food Engineering

This volume presents a state-of-the-art research in biochemistry, molecular biology, and medical application. A glossary of specialized terms is appended. Each chapter is contributed by an expert or group of experts dedicated to increasing our understanding of Dunaliella. The book provides a balanced multidisciplinary communication and contributes to our understanding of this unique alga. It is addressed to graduate students and scientists as a summary of current thoughts on Dunaliella.

This book details the latest developments in sensing technology and its application in the food industry. It explores the opportunities created by the chemical and biosensensing technology, and improvements performed in recent years for better food quality, better food safety, better food processing and control, and better input for food industry. The chapters in this book have been divided into three sections: basic principles of chemical and biosensing technology, biosensors for food processing and control, and biosensors for food safety.

Catalog no. N00093, ISBN: 978-1-57808-545-3 January 2009, 6 x 9, 575 pp. Suggested Price: $139.95 / £89.00

Catalog no. K11046, ISBN: 978-1-4398-1985-2 December 2010, 6-1/8 x 9-1/4, 352 pp. Suggested Price: $159.95 / £99.00

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Analysis of Pesticides in Food and Environmental Samples Edited by

Jose L. Tadeo National Institute for Agricultural and Food Research and Technology (INIA), Madrid, Spain

Defensive Mutualism in Microbial Symbiosis Edited by

James F. White Jr. and Monica S. Torres Rutgers University, New Brunswick, New Jersey, USA Series: Mycology

Presenting the latest research in the field, this multi-authored book critically examines the analytical methods and instrumentation used to determine pesticide residues in soil, water, air, and foods from both vegetal and animal origin. The text introduces pesticide classes and physicochemical properties, followed by trends in sample preparation, pesticide analysis, and quality assurance. It details extraction and determination techniques for analyzing real world samples, contains data on the levels of pesticides found in food and environmental matrices, and addresses regulatory aspects of monitoring for chemicals.

Defensive Mutualism in Microbial Symbiosis includes basic ecology and biological information on defensive mutualisms, explores how they function, and evaluates how they have evolved. It looks at the implications of symbiosis defensive compounds as a new frontier in bioexploration for drug and natural product discovery. The book expands the concept of defensive mutualisms to evaluate defense against environmental abiotic and biotic stresses. Addressing the topic of defensive mutualisms in microbial symbiosis across this wide spectrum, it includes chapters on defensive mutualistic associations involving multiple kingdoms of organisms in terrestrial and aquatic ecosystems--plant, animal, fungi, bacteria, and protozoans.

Catalog no. 7552, ISBN: 978-0-8493-7552-1 February 2008, 6-1/8 x 9-1/4, 384 pp. Suggested Price: $172.95 / £110.00

Catalog no. 69314, ISBN: 978-1-4200-6931-0 May 2009, 7 x 10, 430 pp. Suggested Price: $144.95 / £92.00

Available in eBook

Applied Biomedical Microbiology A Biofilms Approach

Textbook

Environmental Biotechnology

Edited by

M. H. Fulekar

Daryl S. Paulson BioSciences Laboratories, Inc., Bozeman, Montana, USA

Microbiology

Edited by

Department of Life Sciences, University of Mumbai, India

Biofilms now account for over 80 percent of microbial infections in the body. Written from a variety of perspectives by leading researchers, Applied Biomedical Microbiology: A Biofilms Approach presents an in-depth discussion of medically challenging biofilms. It provides a solid foundation in the basic microbiology of biofilms and then goes on to discuss those biofilms associated with medical devices, catheters, and dental unit water lines, as well as those that impact cardiovascular medicine, the gastrointestinal system, periodontal disease, and chronic wounds. A final chapter addresses a variety of methods used to investigate biofilms.

This book provides information essential to students taking courses/modules in biotechnology as part of environmental sciences, environmental management, and environmental biology programs. It is also suitable for those studying water, waste management, and pollution abatement. Topics discussed include biodiversity, renewable energy, bioremediation technology, recombinant DNA technology, genetic engineering, solid waste management, composting, vermicomposting, biofertilizer, chemical pesticides, biological control of pests, and genetically modified organisms. The book also discusses bioethics and risk assessment, intellectual property rights, environmental cleanup technologies, and environmental nanotechnology.

Catalog no. 7569, ISBN: 978-0-8493-7569-9 October 2009, 6-1/8 x 9-1/4, 176 pp. Suggested Price: $133.95 / £85.00

Catalog no. N10286, ISBN: 978-1-57808-582-8 July 2010, 7 x 10, 620 pp., Soft Cover Suggested Price: $89.95 / £57.99

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Fermentation Microbiology and Biotechnology Third Edition

Fundamental Food Microbiology Fourth Edition Bibek Ray

Microbiology

Edited by

University of Wyoming, Laramie, USA

E.M.T. El-Mansi, C.F.A. Bryce, A.L. Demain, and A.R. Allman

Arun Bhunia

Retaining valuable information from the first edition, including fermentation kinetics and flux control analysis, this new edition addresses numerous topics that have risen to importance. New chapters explore the production of primary and secondary metabolites such as amino acids, nucleotides, and vitamins, as well as antibiotics, immunosuppressants, and anti-tumor agents. The authors examine advances in enzyme and co-factor engineering, cell immobilization, and sensor technology. Packed with examples and industry case studies, and requiring only a basic microbiology background, the text is accessible to academic and industry researchers and students.

Maintaining the high standard set by the previous bestselling editions, this fourth edition continues to present the most up-to-date information in this rapidly growing and highly dynamic field. Revised and expanded to reflect recent advances, it includes many new and emerging pathogens as well as descriptions of the mechanism of pathogenesis. An entirely new chapter on detection methods appears in this edition with evaluations of advanced rapid detection techniques using biosensors and nanotechnology. Along with many more easy-to-follow figures and illustrations, each chapter includes an introduction, conclusion, references, and questions.

Catalog no. 5334, ISBN: 978-0-8493-5334-5 October 2006, 7 x 10, 576 pp. Suggested Price: $102.95 / £65.99

Catalog no. 7529, ISBN: 978-0-8493-7529-3 October 2007, 7 x 10, 536 pp. Suggested Price: $73.95 / £46.99

Purdue University, West Lafayette, Indiana, USA

Also Available in Soft Cover

Foodborne Pathogens Hazards, Risk Analysis and Control, Second Edition

Textbook

Fungal Pathogenesis in Plants and Crops Molecular Biology and Host Defense Mechanisms, Second Edition

Edited by

P. Vidhyasekaran

Clive de W. Blackburn and Peter J. Mcclure Unilever Colworth, UK

Tamil Nadu Agricultural University, Coimbatore, India Series: Books in Soils, Plants, and the Environment

As outbreaks of foodborne disease continue to rise, the effective identification and control of pathogens becomes increasingly important for the food industry. With its distinguished international team of contributors, Foodborne Pathogens presents an authoritative and practical guide to effective control measures and how they can be applied to individual pathogens. The book covers general techniques in assessing and managing bacterial hazards, modeling pathogen behavior and carrying out a risk assessment, good management practices, and hygienic process design and operation. It is an essential guide to successful pathogen control in the food industry.

Completely updated and revised, this second edition of the widely acclaimed Fungal Pathogenesis in Plants and Crops covers the fungal infection process, molecular host-defense mechanisms, and events leading to the suppression of these defense mechanisms by fungal pathogens. This second edition features three brand-new chapters on disease resistance and susceptibility genes in signal perception and emission, and cell death signaling in disease susceptibility and resistance. This text also includes additional material on phytoalexins, toxins, signal perception and transduction in fungal pathogenesis, and 17 families of pathogenesis-related proteins.

Catalog no. N10071, ISBN: 978-1-4398-0768-2 July 2009, 6 x 9, 521 pp. Suggested Price: $359.95 / £225.00

Catalog no. DK9867, ISBN: 978-0-8493-9867-4 August 2007, 7 x 10, 536 pp. Suggested Price: $189.95 / £121.00 Available in eBook

Freeze-Drying of Pharmaceutical and Food Products Edited by

Geomicrobiology

Tse-Chau Hua, B.L. Liu, and Hua Zhang

Edited by

Beijing Normal University, People’s Republic of China

S.K. Jain, A.A. Khan and M.K. Rai

Freeze-drying is an important preservation technique for heat-sensitive pharmaceuticals and foods. This informative text addresses the principles and practice of freeze-drying preservation techniques for pharmaceutical and food products. The authors introduce freeze-drying and review the fundamentals of the technique, heat-mass transfer analyses, modelling of the drying process and the equipment employed. They discuss freeze-drying of food, pharmaceuticals and the protective agents and additives applied. The final chapter covers disinfection, sterilization, and process validation.

Geomicrobiology examines the role that microbes have played in the past and are currently playing in a number of fundamental geological processes. The present book is of great importance for researchers working in the field of microbiology, biotechnology, geology, and environmental biotechnology. It can be a major reference book for students as well as researchers. This is a new and rapidly-developing field that has led in the past decade to a radically-revised view of the diversity and activity of microbial life on Earth.

Catalog no. N10143, ISBN: 978-1-4398-2598-3 August 2010, 6 x 9, 256 pp. Suggested Price: $179.95 / £115.00

Catalog no. N10270, ISBN: 978-1-57808-665-8 April 2010, 6 x 9, 320 pp. Suggested Price: $119.95 / £76.99 Available in eBook

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Geomicrobiology Henry Lutz Ehrlich Rensselaer Polytechnic Institute, Troy, New York, USA

Dianne K. Newman

Handbook of Microbiological Media Fourth Edition

Massachusetts Institute of Technology and Howard Hughes Medical Institute, Cambridge, USA

Ronald M. Atlas

This fifth edition presents a survey of various aspects of geomicrobiology, including the microbial role in the formation and degradation of minerals and fossil fuels and elemental cycling. It explores the role of microbes in early evolution, as well as in the lithosphere, deep subsurface, and hydrosphere. This edition includes more foundational information, covering important principles and methods for identification and function of specific microbes in a particular process. Generously laden with tables, graphics, diagrams, and photographs, the remainder of the book examines the geomicrobial aspects of a wide range of minerals.

This latest edition of a bestseller carries on the tradition of CRC handbook excellence. This updated volume lists the formulation, method of preparation, and uses for over four thousand microbiological media. With 30 percent more entries than the previous editions, the book includes recent information on the international collection of microorganisms and expanded information of yeast, algae, and Archaea. The book also contains formulations and uses of media for isolation, culture, identification, and maintenance of microorganisms. The entries are arranged alphabetically by medium name and include synonyms, sources, trademarks, and more.

Catalog no. 7906, ISBN: 978-0-8493-7906-2 December 2008, 7 x 10, 628 pp. Suggested Price: $209.95 / £133.00

Catalog no. K10224, ISBN: 978-1-4398-0406-3 March 2010, 8-1/2 x 11, 2040 pp. Suggested Price: $199.95 / £127.00

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University of Louisville, Kentucky, USA

Guide to Microbiological Control in Pharmaceuticals and Medical Devices

Microbiology

Fifth Edition

Second Edition Edited by

Stephen P. Denyer, Cardiff University, UK Rosamund M. Baird, University of Bath, UK This new edition covers principal aspects of microbiology relevant to the preformulation, formulation, manufacturing, and license application stages involved with the production of pharmaceuticals, while expanding the book’s focus to include medical devices. This work provides a brief introduction to microbiology geared towards the non-microbiologist. Covering good manufacturing practice in the control of contamination, the text explores monitoring microbiological quality, the preservation of pharmaceutical formulations and principles of sterilization, including microbiological specific considerations for biotechnological products and other medical devices. Catalog no. TF2048, ISBN: 978-0-7484-0615-9 December 2006, 6-1/8 x 9-1/4, 504 pp. Suggested Price: $179.95 / £114.00

Laboratory Biosecurity Handbook Reynolds M. Salerno and Jennifer Gaudioso Sandia National Laboratories, Albuquerque, New Mexico, USA

The Laboratory Biosecurity Handbook is a guide to the implementation of pathogen protection programs. The first sections of the book offer an historical overview of biological weapons activity, key principles of biosecurity, and its integration into existing frameworks, as well as a discussion of biosecurity risk. Later sections discuss biosecurity risk assessments, describe detailed components of a biosecurity program, and offer a graded approach to biosecurity through multiple risk levels. The work also covers risk prioritization of biological assets and biosecurity training. Catalog no. 6475, ISBN: 978-0-8493-6475-4 June 2007, 6 x 9, 208 pp. Suggested Price: $113.95 / £72.99 Available in eBook

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Handbook of Food Analysis Second Edition. Three-Volume Set

Manipulative Tenants Bacteria Associated with Arthropods Elinat Zchori-Fein

Edited by

Newe Ya’ar Research Center, Ramat Yishay, Israel

Leo M.L. Nollet

Kostas Bourtzis

University College Ghent, Applied Engineering Sciences, Belgium Series: Food Science and Technology

University of Ioannina, Agrinio, Greece Series: Frontiers in Microbiology

Thoroughly updated and revised, the Handbook of Food Analysis, Second Edition presents an exhaustive compilation of analytical methods essential to every food chemist. This outstanding three-volume reference delineates the physical and chemical properties of nutrients and other food components and provides step-by-step descriptions of preparation, detection, separation, derivatization, and clean-up techniques and assesses the relative advantage, accuracy, and reliability of each procedure. The second edition includes new chapters on biosensors, BMO’s, nanoscale analysis systems, food authenticity, radionuclides concentration, meat factors and meat quality, particle size analysis, scanning colorimetry, and others.

In efforts to summarize the most up-to-date information available on bacterial symbionts of arthropods, this text provides an overview of primary symbionts in addition to 10 of the most abundant secondary symbionts known to date. The editors brought together entomogists and microbiologists to create a full picture of the complex systems, encouraging the integration of theory and practice in efforts to find innovative routes to pest and disease management. The book provides comprehensive knowledge and a unique perspective on a fast-growing field. Figures within the text include diagrams, tables, graphs, pictures, and chemical structures.

Catalog no. DK2311, ISBN: 978-0-8247-5039-8 July 2004, 2296 pp. Suggested Price: $839.00 / £534.00

Catalog no. K11358, ISBN: 978-1-4398-2749-9 June 2011, 6-1/8 x 9-1/4, 224 pp. Suggested Price: $49.95 / £31.99 Available in eBook

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Methods for the Study of DeepSea Sediments, Their Functioning and Biodiversity Edited by

Modern Soil Microbiology Second Edition Edited by

Jan Dirk van Elsas, Janet K. Jansson, and Jack T. Trevors

Roberto Danovaro

Microbiology

Polytechnic University of Marche, Ancona, Italy

Series: Books in Soils, Plants, and the Environment

A comprehensive update on methodologies for the study of deep-sea sediments, this handbook includes information on all living components of the benthos. It covers benthic viruses and prokaryotes (both Bacteria and Archaea), protozoa, foraminifera, meiofauna, macrofauna, and megafauna. After organismal components are discussed in terms of abundance, biomass, and biodiversity, they are integrated according to environmental variables. Each chapter includes sampling procedures, step-by-step laboratory protocols, instrument settings, calculation formulas, and conversion coefficients. Pictures, schemes, and diagrams provide visual support for working scientists.

Over the past decade, the study of soil microbiology has significantly changed, both in the understanding of the diversity and function of soil microbial communities and in the research methods. Completely revised and rewritten, this second edition provides broad, cutting-edge knowledge of a discipline that encompasses ecology, physiology, genetics, molecular biology, and biotechnology and makes use of biochemical and biophysical approaches. The chapters cover topics ranging from the fundamental to the applied, and describe the use of advanced methods that have provided a great thrust to the discipline of soil microbiology.

Catalog no. K10568, ISBN: 978-1-4398-1137-5 December 2009, 7 x 10, 458 pp. Suggested Price: $144.95 / £92.00

Catalog no. DK3097, ISBN: 978-0-8247-2749-9 December 2006, 6 x 9, 672 pp. Suggested Price: $124.95 / £37.99

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Microbial Limit and Bioburden Tests Validation Approaches and Global Requirements, Second Edition Lucia Clontz Diosynth Biotechnology, Schering-Plough, Morrisville, North Carolina, USA

Textbook

Molecular Detection of Foodborne Pathogens Edited by

Dongyou Liu Mississippi State University, USA

Often called the “industry bible,” Microbial Limit and Bioburden Tests: Validation Approaches and Global Requirements provides a practical guide to microbial limit methodologies. This new second edition has been substantially updated and expanded to include the most recent microbial limit tests and bioburden testing mandated by USP-NF. A comprehensive reference source, it reflects current industry standards, regulatory expectations, and the latest technical and scientific information. This edition addresses new topics such as water testing and also includes new chapters that provide complete coverage of biofilms, environmental monitoring, and microbial identification.

One of the most effective ways to control and prevent human foodborne infections is to implement a pathogen surveillance system. Addressing the biology, epidemiology, and pathogenesis of more than 60 microorganisms, Molecular Detection of Foodborne Pathogens demonstrates how to implement a surveillance system that uses state-of-the-art molecular techniques to quickly detect and identify bacterial, fungal, viral, and parasitic pathogens. Each chapter contains a concise review of the discussed pathogen; a detailed description of current molecular procedures for its detection and identification including ready-to-use protocols; and a discussion on further research needs pertaining to improved diagnosis.

Catalog no. 53485, ISBN: 978-1-4200-5348-7 October 2008, 6-1/8 x 9-1/4, 280 pp. Suggested Price: $199.95 / £127.00

Catalog no. 76434, ISBN: 978-1-4200-7643-1 July 2009, 8-1/2 x 11, 905 pp. Suggested Price: $205.95 / £131.00

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Microbiology of Wounds Steven Percival

Molecular Detection of Human Bacterial Pathogens

Advanced Medical Solutions, Ltd., UK

Edited by

Keith Cutting

Dongyou Liu

Buckinghamshire New University, Uxbridge, UK

Mississippi State University, USA

It is not the presence of bacterial organisms, but their interaction with patients that determine their influence on wound healing. This volume discusses the microbiology and biology of human wounds in relation to infection and the biology of the non-healing wound. It presents scientific and clinical information regarding chronic and acute wounds, and discusses inflammation, epithelialization, granulation tissue, and tissue remodeling. It also details techniques for managing chronic and acute wound bioburden and covers the mode of action and efficacy of anti-infectives used in treating wounds.

The second book in a four-part series, this text is an in-depth review of stateof-the-art molecular detection and identification methods for human bacterial pathogens. This book is an authoritative summary of biology, epidemiology, and pathogenesis of major human bacterial pathogens. This book is a handy textbook for undergraduate and graduate students in medical, veterinary, and food microbiology, and contains approximately 750 figures and 750 tables for better comprehension. Topics in this text include classification, morphology and biology, epidemiology, genomics, and diagnoses.

Catalog no. 7993X, ISBN: 978-1-4200-7993-7 April 2010, 6-1/8 x 9-1/4, 407 pp. Suggested Price: $149.95 / £95.00

Catalog no. K10625, ISBN: 978-1-4398-1238-9 April 2011, 8-1/2 x 11, 1184 pp. Suggested Price: $199.95 / £127.00

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Edited by

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Polar Microbiology

Edited by

The Ecology, Biodiversity and Bioremediation Potential of Microorganisms in Extremely Cold Environments

Dongyou Liu

Edited by

Mississippi State University, USA

Asim K. Bej, Jackie Aislabie, and Ronald M. Atlas

With a focus on sample preparation and molecular detection procedures, this text concisely reviews the pathogen concerned in respect to its taxonomy, biology, epidemiology, and pathogenesis. It provides descriptions of clinical sample collection preparation procedures and summaries of molecular detection methods available together with the presentation of a detailed, representative molecular detection protocol for the pathogen. The book also discusses the challenges, limitations, and advantages of the current methods as well as further research needs relating to improved diagnosis.

The only book to cover the breadth of microbial ecology and diversity in polar regions with an emphasis on bioremediation, Polar Microbiology examines polar microorganisms and their ability to degrade petroleum hydrocarbon contaminants in polar terrestrial and aquatic environments. Providing a unique perspective of these microorganisms in extremely cold temperatures, the book focuses on their taxonomy, physiology, biochemistry, population structure, bioremediation potential, and potential for biotechnology applications. Leading investigators provide complete coverage of the microbiology relevant to the study of biodiversity and biodegradation of pollutants in the Arctic and Antarctic.

Catalog no. K10626, ISBN: 978-1-4398-1240-2 June 2011, 8-1/2 x 11, 888 pp. Suggested Price: $199.95 / £127.00

Catalog no. 83848, ISBN: 978-1-4200-8384-2 December 2009, 6-1/8 x 9-1/4, 424 pp. Suggested Price: $164.95 / £102.00 Available in eBook

Molecular Detection of Human Viral Pathogens

Practical Atlas for Bacterial Identification

Edited by

Second Edition

Dongyou Liu

D. Roy Cullimore

Mississippi State University, USA

Droycon Bioconcepts Inc., Regina, Saskatchewan, Canada

The first in a series of four books, this comprehensive work details the molecular detection of major human viral, bacterial, fungal, and parasitic pathogens. Focusing on sample preparation and molecular detection procedures, each chapter presents a concise review of the pathogen concerned including its taxonomy, biology, epidemiology, and pathogenesis; a description of clinical sample collection preparation procedures; a summary of molecular detection methods; representative molecular detection protocols; and a discussion on the challenges, limitations, and advantages for the current methods as well as further research required to improve diagnosis.

In a radical departure from the classical reductionist identification of bacteria dominated by genetic and biochemical analysis of separated strains of bacteria, this book takes a generalistic approach utilizing the form, function, and habitat of communities of bacteria. This complete revised and updated second introduces the concept of bacteria community intelligence as reflected in corrosion, plugging, and shifts in the quality parameters in water, gas, oil, food, or even air. The book allows readers to start with a symptom, uncover the bacterial activities, and then indentify the communities distinctly enough to allow management and control.

Catalog no. K10623, ISBN: 978-1-4398-1236-5 December 2010, 8-1/2 x 11, 1180 pp. Suggested Price: $199.95 / £127.00

Catalog no. 87975, ISBN: 978-1-4200-8797-0 March 2010, 6-1/8 x 9-1/4, 327 pp. Suggested Price: $139.95 / £89.00 Available in eBook

Pictorial Atlas of Soil and Seed Fungi

Practical Handbook of Microbiology

Morphologies of Cultured Fungi and Key to Species, Third Edition

Second Edition

Tsuneo Watanabe

Emanuel Goldman

Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan

This third edition describes and illustrates more than 515 fungal species, including 49 oomycetous, 35 zygomycetous, 49 ascomycetous, 38 basidiomycetous, and 344 anamorphic species. All fungi are described alphabetically in order of Oomycota, Zygomycota, Ascomycota, Basidiomycota, and Anamorphic (Deuteromycetous) fungi. For each genus, the atlas includes type species, references, morphology, and materials. The book illustrates all fungi alongside morphologies and colonies of their fresh agar cultures or dried specimens, providing ready access to morphologically similar fungi for quick comparison. This edition contains CDROM, which includes color versions of all images from the book. Catalog no. K10231, ISBN: 978-1-4398-0419-3 May 2010, 8-1/2 x 11, 426 pp. Suggested Price: $159.95 / £99.00

Microbiology

Molecular Detection of Human Fungal Pathogens

Edited by

University of Medicine & Dentistry of New Jersey, USA

Lorrence H. Green Westbury Diagnostics Inc., New York, USA

The second edition of the bestselling Practical Handbook of Microbiology provides in-depth chapters on all aspects of the field, from classical microbiology to genomics. Reflecting the recent, sweeping changes in the field, yet retaining the popular format of the original, this second edition includes many chapter rewrites and more than 20 new or expanded chapters. Various brief taxonomy chapters from the first edition are now complete chapters with descriptions of genus and species, and several tables have been updated and revised along with the addition of a new survey table of selected eubacteria. Catalog no. 9365, ISBN: 978-0-8493-9365-5 August 2008, 7 x 10, 864 pp. Suggested Price: $172.95 / £110.00 Available in eBook

Available in eBook For more information and a complete list of titles, visit us at www.crcpress.com

Probiotic Foods in Health and Disease Edited by

G. B. Nair and Yoshifumi Takeda

Microbiology / Molecular Biology 18

A blend of fundamental and applied research, this volume looks at how probiotics can enhance human health. The book covers all aspects of intestinal microflora and while the focus remains on the recent findings in the field of gut health, this book also looks at the possible role of probiotics beyond the gut such as in oral health care, allergic disorders, and women’s health. The book also reviews pertinent legislation across the globe with special emphasis on Japan, which pioneered the establishment of a regulatory framework for functional foods. Catalog no. N10312, ISBN: 978-1-57808-698-6 November 2010, 7 x 9.5, 150 pp., Soft Cover Suggested Price: $89.95 / £57.99

Topical Antimicrobials Testing and Evaluation Second Edition Edited by

Daryl S. Paulson BioSciences Laboratories, Inc., Bozeman, Montana, USA

Providing industry and academia with the ways of getting products approved by the FDA and the means of servicing expanding markets, this work presents and reviews techniques for testing antibacterial compounds. It discusses and illustrates the most effective methods for testing efficacy and safety of preinjection and preoperative washes, healthcare and food service workers’ handwashes, and surgical scrubs. Catalog no. K10678, ISBN: 978-1-4398-1322-5 June 2011, 6 x 9, 376 pp. Suggested Price: $149.95 / £95.00 Available in eBook

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Rapid Detection and Characterization of Foodborne Pathogens by Molecular Techniques

Cancer Epigenetics Edited by

Robert E. Levin

Trygve Tollefsbol

University of Massachusetts, Amherst, USA

University of Alabama at Birmingham, USA

Written by one of the most prolific and respected researchers in food safety, this book describes molecular techniques for the detection and discrimination of major infectious bacteria associated with foods. Each chapter deals with a specific organism and techniques applied to that organism. Particular focus is placed on genes associated with pathogenicity used in the polymerase chain reaction (PCR) including real-time PCR for specific detection of pathogenic bacteria and the inherent limitations of such methodology with certain pathogens. Methods for extracting microorganisms from complex food matrices and DNA purification techniques are also emphasized.

Heredity is not the sole determining factor in disease development, and the field of epigenetics is now the focus of many of the most exciting and significant advances in cancer research. Providing the most up-to-date and relevant information available, this text presents in-depth discussions of DNA methylation analysis and cancer, histone modifications and cancer, and other epigenetic aspects of cancer. This book explores the role of epigenetics in the diagnosis, prognosis, and therapy of cancer and offers a comprehensive overview of current and potential new epigenetics advancements.

Catalog no. 92421, ISBN: 978-1-4200-9242-4 October 2009, 6-1/8 x 9-1/4, 608 pp. Suggested Price: $174.95 / £111.00

Catalog no. 45792, ISBN: 978-1-4200-4579-6 September 2008, 7 x 10, 472 pp. Suggested Price: $162.95 / £102.00 Available in eBook

Available in eBook

Sensory Evaluation Techniques Fourth Edition Gail Vance Civille

Epigenetics in Biology and Medicine

Sensory Spectrum Incorporated, New Providence, New Jersey, USA

Edited by

B. Thomas Carr

Manel Esteller

Carr Consulting, Evanston, Illinois, USA

Spanish National Cancer Centre, Madrid, Spain

Sensory Evaluation Techniques, Fourth Edition covers all phases of sensory evaluation. Like its bestselling predecessors, this edition details sensory tests currently in use, promotes understanding of these tests, and describes major sensory evaluation practices. New to this edition are an expanded chapter on the Spectrum™ method of descriptive sensory analysis, a set of revised flavor intensity scales, an overview of Thurstonian scaling, and a detailed discussion of data-relationship techniques. With numerous examples and sample tests, this book remains an essential resource that illustrates the development of sensory perception testing.

At present more than a dozen drugs that target epigenetic changes are in clinical trials. Epigenetics in Biology and Medicine offers a comprehensive overview of epigenetics, both in normal functions and disease states. This book presents contributions from international experts, addressing both theoretical and methodological issues. It discusses cell biology and the role of epigenetics in human, animal, and plant diseases. The text also covers DNA methylation inhibitors, histone modifications, and epigenomics, as well as the impact that diet has on epigenetic changes.

Morten C. Meilgaard Ann Arbor, Michigan, USA

Catalog no. 3839, ISBN: 978-0-8493-3839-7 December 2006, 7 x 10, 464 pp. Suggested Price: $102.95 / £65.99

Catalog no. 7289, ISBN: 978-0-8493-7289-6 September 2008, 6-1/8 x 9-1/4, 312 pp. Suggested Price: $162.95 / £102.00 Available in eBook

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Protein Folding and Metal Ions

A Practical Guide

Mechanisms, Biology and Disease

Edited by

Albert D. Donnenberg

Claudio M. Gomes

Hillman Cancer Center, Pittsburgh, Pennsylvania, USA

Universidade Nova de Lisboa, Portugal

Fiona Elizabeth Craig

Pernilla Wittung-Stafshede

University of Pittsburgh, Pennsylvania, USA

Umea University, Sweden

This book details six of the most useful topics in flow cytometry derived from six lectures by recognized experts in the field. Each lecture is accompanied by easy-toread expert commentary. The cutting-edge chapters cover a wide array of topics including designing a flow cytometry experiment, rare event analysis, functional assays, assays of cell proliferation, solid tissues, and imaging flow cytometry. Each topic is carefully discussed for its current relevance in the field, its importance in biomedical research, and the frequency of its misuse in the scientific literature.

The role of metal ions in protein folding and structure is critical to a range of scientists. This volume provides case study examples of protein folding and stability studies in particular systems or proteins that comprise different metal ions of cofactors. It reviews the proteins that shuttle metal ions in the cell to a particular target metalloprotein. It also illustrates how metal binding can be connected to pathological protein conformations in unrelated diseases. The final section addresses protein redesign of metal-containing proteins by computational methods, folding simulation studies, and work on model peptides.

Catalog no. K10037, ISBN: 978-1-4398-0034-8 May 2011, 6-1/8 x 9-1/4, 512 pp. Suggested Price: $149.95 / £95.00 Available in eBook

Catalog no. K10482, ISBN: 978-1-4398-0964-8 October 2010, 6-1/8 x 9-1/4, 308 pp. Suggested Price: $149.95 / £95.00 Available in eBook

Handbook of Nucleic Acid Purification

Regulation of Gene Expression by Small RNAs

Edited by

Dongyou Liu

Rajesh K. Gaur and John J. Rossi

Mississippi State University, USA

Beckman Research Institute, Duarte, California, USA

An all-encompassing volume on nucleic acid purification strategies for bacteria, viruses, fungi, parasites, mammals, and plants, this book emphasizes sample preparation methods for direct molecular applications. Each chapter provides a concise review of historical background and purification principles, a detailed description of current techniques, including several state-of-art protocols for large and small-scale preparations, and a discussion for future development trends. A comprehensive reliable reference, the book supplies a useful roadmap for clinical, forensic, and research scientists involved in the molecular analysis of biological specimens.

Recent research demonstrates that defects in the processing mechanisms of small non-coding RNAs are linked to various human diseases. This text explores the latest research on microRNAs and their functional roles in cells and organisms. Written by international experts, discussion includes the identification, characterization, and structure-function analysis of microRNAs; the study of microRNAs in development, cancer, and viruses; and the applications of microRNAs with respect to gene regulation, functional genomics, and therapeutics. This book is a valuable reference for established researchers as well as fellows and advanced students.

Catalog no. 70967, ISBN: 978-1-4200-7096-5 January 2009, 7 x 10, 584 pp. Suggested Price: $164.95 / £105.00

Catalog no. 9169, ISBN: 978-0-8493-9169-9 April 2009, 6-1/8 x 9-1/4, 440 pp. Suggested Price: $154.95 / £99.00

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Advances in the Neuroscience of Addiction Edited by

Cynthia M. Kuhn

Microarray Methods and Protocols Robert S. Matson Beckman Coulter, Fullerton, California, USA

This volume provides insight into present and future uses for microarray technology. The book presents an overview of companies providing arrays, the type of arrays available, array construction processes, substrate chemistry, array printing, and quality control. With a focus on nucleic acid microarrays of biomedical relevance and the use of microarrays in drug discovery, the text describes the application of gene expression arrays to identify drug targets for human diseases and to predict possible drug toxicity problems. The relatively new field of protein microarray technology is also discussed. Catalog no. 46659, ISBN: 978-1-4200-4665-6 January 2009, 6-1/8 x 9-1/4, 216 pp., Soft Cover Suggested Price: $133.95 / £85.00 Available in eBook

Duke University Medical Center, Durham, North Carolina, USA

George F. Koob The Scripps Research Institute, La Jolla, California, USA Series: Frontiers in Neuroscience

Featuring contributions from leading experts, this book presents an excellent overview of the available and emerging approaches used to investigate the neurobiological mechanisms of drug addiction. Discussion includes the behavioral strategies and characteristics of addiction as well as mechanistic approaches to understanding the underlying neurobiology. The authors provide information from mathematical models, model organisms, animal models, and experiments conducted in humans. They deliver a comprehensive introduction to the methodologies of the field for students and beginning researchers and an essential reference source for established investigators. Catalog no. 7391, ISBN: 978-0-8493-7391-6 April 2010, 6-1/8 x 9-1/4, 238 pp. Suggested Price: $139.95 / £89.00 Available in eBook

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Molecular Biology / Neuroscience

Flow Cyclometry

Atlas of the Neonatal Rat Brain

Inventing the Future of Neurology

Renuka Ramachandra

Hojjat Adeli

Penn State Hershey Medical Center, USA

Ohio State University, Columbus, USA

Thyagarajan Subramanian

Samanwoy Ghosh-Dastidar

Neuroscience

Penn State University, Hershey, USA

Ardmore, Pennsylvania, USA

The first histological atlas of the rat neonatal brain, this volume provides researchers in neurology and pharmacology, as well as biology and veterinary science with the detailed color images of the normal developing rat brain required for their research. Each plate is a photomicrograph composite that shows the entire brain in sagittal and coronal sections at each stage stained with cresyl violet. Various brain nuclei and their connections are specifically labeled. Since changes in the rat brain post-birth are so rapid, images are provided for postnatal days one, five, and fifteen.

This book presents a novel approach for automated EEG-based diagnosis of neurological disorders such as epilepsy. The authors have developed an innovative method that has been shown to diagnose epilepsy and detect seizure with an accuracy rate of 96 percent. Their method is based on the adroit integration of three computing and problem solving paradigms: neural networks, wavelets, and chaos theory. The text introduces each of these computing paradigms along with a number of sophisticated mathematical algorithms. It concludes with applications of the method to epilepsy and to Alzheimer’s disease.

Catalog no. K11857, ISBN: 978-1-4398-4012-2 February 2011, 8-1/2 x 11, 188 pp. Suggested Price: $159.95 / £108.00

Catalog no. K10784, ISBN: 978-1-4398-1531-1 February 2010, 6-1/8 x 9-1/4, 423 pp. Suggested Price: $159.95 / £99.00

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Augmenting Cognition Idan Segev The Hebrew University, Jerusalem, Israel

Henry Markram

Concussive Brain Trauma Neurobehavioral Impairment & Maladaptation, Second Edition Rolland S. Parker New York University School of Medicine, USA

Swiss Federal Institute of Technology, Lausanne

Automated EEG-Based Diagnosis of Neurological Disorders

Modern medicine has few options to treat those with cognitive deficiencies, and as we learn more about the biology of diminished cognition, we consider the design of a new class of therapies to restore and augment cognition. This book describes a number of the foundational areas of cognitive enhancement, with chapters devoted to the following subject areas: use of stem cells, savants, posttraumatic stress disorder, deep-brain stimulation, music and dance, virtual reality, role of sleep, longevity, drugs, and the brain-computer interface.

Continuing the tradition of the bestselling first edition, this second edition provides comprehensive coverage of neurobehavioral disorders in children and adults following impact and acceleration accidents. Completely revised and updated, the book includes comprehensive coverage of consciousness including normal, acute, and persistent alterations. Drawing on his training, education, and experience in human physiology, neuroanatomy, and endocrinology, the author not only gives readers a solid foundation for understanding, diagnosing, and treating concussive brain trauma, but also gives them tools to increase standards of care.

Catalog no. N10260, ISBN: 978-1-4398-3993-5 March 2011, 6 x 9, 250 pp. Suggested Price: $89.95 / £57.99

Catalog no. 8039, ISBN: 978-0-8493-8039-6 March 2011, 7 x 10, 976 pp. Suggested Price: $159.95 / £99.00

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Epilepsy Mechanisms, Models, and Translational Perspectives Edited by

Autism Oxidative Stress, Inflammation, and Immune Abnormalities Abha Chauhan, Ved Chauhan and Ted Brown

Jong Rho Alberta Children’s Hospital, Canada

Raman Sankar University of California School of Medicine, Los Angeles, USA

New York State Institute for Basic Research in Developmental Disabilities, Staten Island, USA

Carl E. Stafstrom

Recently, the Center for Disease Control issued an alert indicating that autism may impact one out of every 150 children. While the syndrome is still officially labeled as idiopathic, research shows the cause of autism may possess genetic, environmental, and possibly immunological factors and that it has at least one correlation to oxidative stress. This book is a collection of research that has found links between autism and a number of oxidative stress-related abnormalities such as neuroinflammation, mitochondrial dysfunction, membrane and metabolism abnormalities, and signal transduction. The text also reports on potential avenues for new therapeutic intervention strategies.

Written for researchers and clinicians in neurology and neuroscience, this text offers a bridge across the so-called translational divide, to cover innovative treatment strategies that, while based on scientific principles, have yet to be tested rigorously in clinical settings. The text features the contributions of leading researchers in adult and pediatric epilepsy who cover a range of topics including gene therapy, metabolic regulation, and neuroprotective strategies. It offers an understanding of the pathogenesis and mechanisms of various epilepsy syndromes, highlights therapies with the greatest potential, and identifies challenges common to researchers.

Catalog no. 68814, ISBN: 978-1-4200-6881-8 October 2009, 6-1/8 x 9-1/4, 452 pp. Suggested Price: $164.95 / £102.00

Catalog no. 8559X, ISBN: 978-1-4200-8559-4 June 2010, 7 x 10, 684 pp. Suggested Price: $189.95 / £121.00

Available in eBook

University of Wisconsin, Madison, USA

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The Intersection of Neurosciences, Biology, Mathematics, Engineering and Physics

The Female Brain Second Edition

Edited by

Cynthia L. Darlington

Ivan Osorio, Hitten Zaveri, Mark G. Frei, and Susan Arthurs

Series: Conceptual Advances in Brain Research

Integrating the studies of epilepsy, neurosciences, computational neurosciences, mathematics, physics, engineering, and medicine, this volume provides the first means to a clear, structured, and enriching multidisciplinary perspective for developing students, researchers, and clinicians in the field of epilepsy. The text gives up-to-date information on the state of current research, possible future research, and clinical directions in the fields of epilepsy and seizure dynamics. Clear illustrations that the patterns of brain electrophysiology and behavioral manifestations are provided to aid comprehension. The authors include extensive references in each chapter.

The first edition of this bestseller laid the groundwork for understanding the female brain. Addressing a wealth of new research, the second edition continues in this vein, leading readers through the basic principles of anatomy and physiology and on to the complex behavioral functions which constitute the workings of the normal and abnormal female brain. Filled with rigorous scientific analysis in an easily accessible format, the book delineates gender-based differences between brains and explains why they should be considered when designing research and clinical studies.

Catalog no. K11766, ISBN: 978-1-4398-3885-3 April 2011, 7 x 10, 568 pp. Suggested Price: $189.95 / £121.00

Catalog no. 77449, ISBN: 978-1-4200-7744-5 April 2009, 6-1/8 x 9-1/4, 266 pp. Suggested Price: $133.95 / £85.00 Available in eBook

Available in eBook

Epileptic Seizures and the EEG Measurement, Models, Detection and Prediction Andrea Varsavsky and Iven Mareels The University of Melbourne, Australia

The Neural Bases of Multisensory Processes

Neuroscience

Epilepsy

Edited by

Micah M. Murray CIBM, Lausanne, Switzerland

Mark Thomas Wallace

Mark Cook St. Vincent’s Hospital and the University of Melbourne, Victoria, Australia

Vanderbilt Brain Institute, Nashville, Tennessee, USA Series: Frontiers in Neuroscience

A study of epilepsy from an engineering perspective, this volume begins by summarizing the physiology and the fundamental ideas behind the measurement, analysis, and modeling of the epileptic brain. It introduces the EEG and provides an explanation of the type of brain activity likely to register in EEG measurements, offering an overview of how these EEG records are and have been analyzed in the past. The book focuses on the problem of seizure detection and surveys the physiologically based dynamic models of brain activity. Finally, it addresses the fundamental question: can seizures be predicted?

Introducing groundbreaking original research and reviews, this indispensible reference provides a current review of the state-of-the-field focusing on the neural bases that form the foundation of multisensory processes. Accessible to a multidisciplinary scientific audience as well as non-specialists, this comprehensive overview is divided into seven sections, including combinatorial principles and modeling, anatomy, learning, plasticity, development and aging, clinical manifestations, and attention and spatial representations. It addresses the movement toward more naturalistic multisensory processes and includes translational perspectives across multiple species and methodologies.

Catalog no. K10604, ISBN: 978-1-4398-1200-6 December 2010, 6-1/8 x 9-1/4, 380 pp. Suggested Price: $139.95 / £89.00 Available in eBook

Catalog no. K10614, ISBN: 978-1-4398-1217-4 June 2011, 6-1/8 x 9-1/4, 512 pp. Suggested Price: $149.95 / £95.00 Available in eBook

Fat Detection Taste, Texture, and Post Ingestive Effects

In Vivo Optical Imaging of Brain Function

Jean-Pierre Montmayeur

Second Edition

Centre des Sciences du Hout, Dijon, France

Edited by

Johannes le Coutre

Ron D. Frostig

Nestle Research Center, Lausanne, Switerland Series: Frontiers in Neuroscience

University of California, Irvine, USA Series: Frontiers in Neuroscience

Taking a multidisciplinary approach, this volume sheds new light on critical concerns regarding dietary fat and its relation to obesity. Going far beyond the well-known concerns, it offers new scientific data on the many aspects of fat, including psychological, behavioral, genetic, and physiological factors that contribute to its desirability, perception, intake, and impact on human health. Bringing together cross-disciplinary research, it includes information on genetic predisposition, neural imaging, endocrine impacts on metabolism, and also provides a progressive integrated view on fat taste, fat preference, and nutrition at the molecular level.

Like the original, this new edition reaches across disciplines to review a variety of noninvasive optical techniques used to study activity in the living brain. Leading authorities from such diverse areas as optical hardware, cognitive behavior, and neuroscience present a host of perspectives that range from a single neuron to large assemblies of neurons several million strong, captured at various temporal and spatial resolutions. Introducing techniques that were unavailable just a few years ago, the book describes their theory, setup, analytical methods, and examples that highlight the advantages of each particular method.

Catalog no. 67753, ISBN: 978-1-4200-6775-0 September 2009, 6-1/8 x 9-1/4, 643 pp. Suggested Price: $154.95 / £99.00

Catalog no. 76841, ISBN: 978-1-4200-7684-4 May 2009, 6-1/8 x 9-1/4, 428 pp. Suggested Price: $154.95 / £99.00 Available in eBook

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Textbook

The Integrated Nervous System A Systematic Diagnostic Approach Walter J. Hendelman University of Ottawa, Ontario, Canada

Peter Humphreys Children’s Hospital of Eastern Ontario, Canada

Edited by

Andre Mercanzini Faculty of Engineering, Swiss Federal Institute of Technology Lausanne, (EPFL), Switzerland

Neuroscience

Christopher Skinner

Philippe Renaud

Ottawa Hospital, Ontario, Canada

Despite their demonstrated effectiveness, the long term use of microscale neuroprosthetic devices is compromised by the post-implantation tissue reaction that often forms around the device. This book studies ways to improve the tissue reaction to implanted neuroprosthesis by use of a controlled drug release mechanism, quantified by novel measurement techniques. The author describes solutions to the problem of tissue reaction around microscale neuroprostheses and an also examines an improvement in neural stimulation and recording capability. The author, Andre Mercanzini, is Review Editor for Frontiers in Neuroengineering. He holds two U.S. patents on microassembly.

To demonstrate the connection between academic neuroanatomy and the practice of clinical neurology, this innovative textbook presents carefully chosen clinical cases that illustrate how the nervous system is constructed and how it functions under normal circumstances. Providing the foundation needed to encounter neurological diseases, it teaches students and residents how to integrate a patient’s clinical history and examination with neuroanatomy. In addition to color illustrations, the book adds an invaluable DVD for further exploration and access to a state-of-the-art website with additional materials that are updated periodically. Catalog no. 45970, ISBN: 978-1-4200-4597-0 September 2009, 8-1/2 x 11, 352 pp. Suggested Price: $82.95 / £52.99

Maldynia Multidisciplinary Perspectives on the Illness of Chronic Pain Edited by

James Giordano Director, Center for Neurotechnology Studies, Potomac Institute for Policy Studies, Arlington, VA, USA

Microfabricated Cortical Neuroprostheses

An in depth examination of maldynia, also known as chronic pain, this book explores pain as a bio-cultural phenomenon that necessitates reexamination of medical philosophy, ethics, education, and practice. It provides a historical account of pain and then frames it with contemporary neurobiological perspectives. This book supplies a foundation upon which to illustrate (1) how what we know about pain could and should influence medical education, and the scope, and value (s) of medical practice, and (2) how a knowledge of the history and present considerations of pain might help to construct meaningful, patientcentered medicine. Catalog no. K11642, ISBN: 978-1-4398-3630-9 December 2010, 6-1/8 x 9-1/4, 280 pp. Suggested Price: $149.95 / £95.00 Available in eBook

Methods of Behavior Analysis in Neuroscience,

Catalog no. N10256, ISBN: 978-1-4398-3754-2 September 2010, 6 x 9, 250 pp. Suggested Price: $89.95 / £57.99

Micronutrients and Brain Health Edited by

Lester Packer, Helmut Sies, Manfred Eggersdorfer, and Enrique Cadenas Series: Oxidative Stress and Disease

Under the direction of leading experts in oxidative stress, this book addresses cutting-edge areas of research regarding micronutrients and the brain: It discusses identification of brain-specific micronutrients that support function and molecular mechanisms underlying neuroprotectant activity. The book covers agerelated metabolic pathways, mitochondrial nutrients, and neurodegeneration. Additional chapters cover flavonoids, cell signaling, and neuronal functions, as well as the role of choline, amino acids, metals, and other micronutrients in brain health and function. The text places a particular emphasis on lipoic acid, which is shown to be a therapeutic agent in neuropathologies. Catalog no. 73516, ISBN: 978-1-4200-7351-5 October 2009, 7 x 10, 460 pp. Suggested Price: $174.95 / £111.00 Available in eBook

Neurobiology of Huntington’s Disease Applications to Drug Discovery

Second Edition

Edited by

Duke University Medical Center, Durham, North Carolina, USA

Donald C. Lo

Jerry J. Buccafusco Medical College of Georgia, Augusta, USA Series: Frontiers in Neuroscience

Robert E. Hughes Buck Institute for Age Research, Novato, California, USA Series: Frontiers in Neuroscience

A comprehensive reference for the most well-studied behavioral approaches in animal subjects, this book provides a better understanding of disease effects and new therapeutic treatments. The second edition features new material on the relevance of transgenic mouse models for Alzheimer’s disease, behavioral methods for assessing the cognitive impairment associated with major psychotic disorders, the revival of the scopolamine reversal model for assessing the clinical relevance of new AD drugs, and new approaches to assessing cognitive impairment in aged mice. Each chapter presents theoretical background, methodology, and data interpretation.

Focusing on Huntington’s disease, Neurobiology of Huntington’s Disease highlights advances in the discovery and development of new drug therapies for neurodegenerative disorders. It discusses genetics, genomics, and proteomics, and the latest in high-throughput and high-content screening. The authors provide introductory background as well as highly sophisticated information on current and future directions of research. Exploring the interplay between academic and industrial research, the investment community, and non-profit contributors, the book also examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage.

Catalog no. 52349, ISBN: 978-1-4200-5234-3 October 2008, 6-1/8 x 9-1/4, 360 pp. Suggested Price: $157.95 / £99.00

Catalog no. 9000, ISBN: 978-0-8493-9000-5 July 2010, 6-1/8 x 9-1/4, 338 pp. Suggested Price: $149.95 / £95.00

Available in eBook

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Neurotechnology The Neurobiology of Olfaction Edited by

Premises, Potential and Problems Edited by

James Giordano

Anna Menini

The Neurobiology of Olfaction provides a comprehensive overview of the present status of knowledge and research on olfaction. With an interdisciplinary approach, it includes content from genetics to behavior and from nematodes to humans. It also contains chapters about recent discoveries on odor coding from the olfactory epithelium to cortical centers and neurogenesis in the olfactory epithelium and the olfactory bulb. Each subject-specific chapter is written by a top researcher in the field and provides an extensive list of reviews and original articles for students and scientists interested in further readings. Catalog no. 71971, ISBN: 978-1-4200-7197-9 November 2009, 7 x 10, 448 pp. Suggested Price: $164.95 / £102.00 Available in eBook

This text presents a unique, integrative perspective that examines how studies and developments in neurotechnololgy are both impacted by, and affect the philosophical foundations of the human condition. As the first book in the series Advances in Neurotechnology: Ethical, Legal and Social Issues, this work establishes the current state of neurotechnology and defines the philosophical and ethical issues in neuroscience, neuroengineering, biomedical engineering, computer science, and nanoscience. It also specifically addresses core questions that are integral to the intellectual and pragmatic dimensions of the rapidly progressing field of neurotechnology. Catalog no. K11241, ISBN: 978-1-4398-2586-0 June 2011, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $119.95 / £76.99 Available in eBook

Parkinson’s Disease Neurobiology of Sensation and Reward Jay A. Gottfried

Neuroscience

Director, Center for Neurotechnology Studies, Potomac Institute for Policy Studies, Arlington, VA, USA Series: Advances in Neurotechnology Research and Applications

S.I.S.S.A, Trieste, Italy Series: Frontiers in Neuroscience

Second Edition Edited by

Manuchair Ebadi University of North Dakota, Grand Forks, USA

Northwestern University, Chicago, Illinois, USA Series: Frontiers in Neuroscience

Ronald F. Pfeiffer

This book explores what reward processing can teach us about the senses and what sensory processing can teach us about reward. In examining the neurobiological interface between sensation and reward, the book reveals how the instrinsic properties of sensory systems effectively define and constrain the ambitions of reward-related processing in human and non-human brains. With contributions from leading investigators in the fields of sensation and reward, the text injects the “sensory” back into the study of reward processing and the “rewarding” back into the study of sensory processing.

A new optimism that Parkinson’s disease can be defeated is energizing the research community. Halting the progression of the disease, restoring function, and even prevention are all realistic goals. This comprehensive volume provides state-ofthe-art information on all aspects of Parkinson’s disease, including epidemiology, genetics, diagnosis, treatment, and social issues. Novel and attractive models are included to simplify difficult-to-understand concepts. With a focus on therapeutics and written by leaders in the field, Parkinson’s Disease emphasizes both the importance of early diagnosis and the search for more effective therapies.

Catalog no. 67265, ISBN: 978-1-4200-6726-2 March 2011, 7 x 10, 520 pp. Suggested Price: $149.95 / £95.00

Catalog no. K10361, ISBN: 978-1-4398-0714-9 June 2011, 8-1/2 x 11, 1408 pp. Suggested Price: $249.95 / £159.00

Available in eBook

Neuroproteomics Edited by

The Role of Dopamine in the Basal Ganglia

Oscar Alzate

Edited by

University of Tennessee Health Science Center, Memphis, USA

University of North Carolina, Chapel Hill, USA Series: Frontiers in Neuroscience

Susan Jones

Edited by Oscar Alzate, this is the newest volume in the CRC Frontiers of Neuroscience Series. With an extensive background in mathematics and physics, Dr. Alzate exemplifies the newest generation of biological systems researchers. He organizes an overview of neuroproteomics that is practical and progressive. Approaches discussed include mass spectrometry, electrophoresis, chromatography, surface plasmon resonance, protein arrays, immunoblotting, computational proteomics, and molecular imaging. Writing about their work, leading researchers detail the principles, approaches, and difficulties of the techniques, showcasing the questions that neuroproteomics can answer and those it raises.

This book is an exploration of the nature of dopamine-glutamate interactions in the basal ganglia, from receptor molecules to complex behaviors. It covers anatomy, the subtypes and signaling pathways of dopamine and glutamate receptors expressed in the basal ganglia, and their interaction and the molecular level. The cover includes endogenous and exogenous modulators of this interaction and the implications of dopamine-glutamate interactions at the level of physiological and behavioral measurements of key basal ganglia functions. It also examines the concept that compromised dopamine-glutamate interactions may underpin basal ganglia disorders.

Catalog no. 76256, ISBN: 978-1-4200-7625-7 October 2009, 6-1/8 x 9-1/4, 354 pp. Suggested Price: $164.95 / £102.00

Catalog no. 88793, ISBN: 978-1-4200-8879-3 June 2011, 6-1/8 x 9-1/4, 416 pp. Suggested Price: $149.95 / £95.00

Available in eBook

Series: Frontiers in Neuroscience

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Translational Pain Research From Mouse to Man Edited by

Neuroscience / Nutrition Science 24

Lawrence Kruger

TRP Channels

University of California, Los Angeles, USA

Edited by

Alan R Light

Michael Xl Zhu

University of Utah, Salt Lake City, USA Series: Frontiers in Neuroscience

The University of Texas Health Science Center at Houston, USA Methods in Signal Transduction Series

The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, this book examines rodent models for pain associated with bone cancer, osteoarthritis, and cardiac episodes. It covers the cloning of highly specific receptors and the analysis of modular molecular mechanisms relevant to painful neuropathies, while also considering the bearing of this trend toward translational research on the commercial pharmaceutical establishment.

The purpose of this book is to provide detailed methods for the study of TRP channels. It includes expression and functional studies of TRP channels in heterologous systems as well as structural and functional studies of TRP channels. The author also explores various methods for detailed analysis of biophysical properties of TRP channels. In addition, the text covers high-throughput screening assays for TRP channels and offers novel and effective approaches to study endogenous TRP channel function in native systems.

Catalog no. K10609, ISBN: 978-1-4398-1209-9 November 2009, 6-1/8 x 9-1/4, 432 pp. Suggested Price: $164.95 / £102.00

Catalog no. K10983, ISBN: 978-1-4398-1860-2 April 2011, 6-1/8 x 9-1/4, 440 pp. Suggested Price: $149.95 / £95.00 Available in eBook

Available in eBook

Traumatic Brain Injury

Adipose Tissue and Inflammation

Methods for Clinical and Forensic Neuropsychiatric Assessment, Second Edition

Edited by

Robert P. Granacher, Jr. University of Kentucky, Lexington, USA

State University of New York, Buffalo, USA Series: Oxidative Stress and Disease

A comprehensive introduction to evaluating and treating patients with traumatic brain injuries, this second edition of a bestseller features new information regarding the epidemiology and pathophysiology of brain injury. It also discusses structural and functional imaging in the assessment of traumatic brain injury, including functional MRI, PET scanning, and magnetic resonance spectroscopy. With expanded discussions of brain-injury malingering and family dynamics, this revised and updated text gives an overview of state-of-the-art techniques and discusses new pharmacological treatments, acquired psychopathy, and test instruments for assessing behavior.

Obesity leads to a host of pathologies, including cardiovascular disease, insulin resistance, and metabolic syndrome. Central to all of these pathologies is the concept that obesity produces chronic inflammation. Featuring contributions from international experts in the fields of adiposity, inflammation, adipokines, and pharmaconutrition, this book focuses on the effects of obesity on systemic inflammation. The text addresses the epidemiology of obesity-induced inflammation, the adipokine mediators that link adipose tissue to inflammation, the influence of hormones on adipose inflammation, and the roles of nutrients, lifestyles, and pharmacotherapy in reducing inflammation and obesity.

Catalog no. 8138, ISBN: 978-0-8493-8138-6 December 2007, 7 x 10, 584 pp. Suggested Price: $162.95 / £102.00

Catalog no. 91301, ISBN: 978-1-4200-9130-4 October 2009, 6-1/8 x 9-1/4, 318 pp. Suggested Price: $154.95 / £99.00

Available in eBook

Atif B. Awad and Peter G. Bradford

Textbook

Traumatic Brain Injury Rehabilitation, Treatment, and Case Management, Third Edition

Advanced Nutrition Macronutrients, Micronutrients, and Metabolism Carolyn D. Berdanier

Edited by

Professor Emerita, University of Georgia, Athens, USA

Mark J. Ashley

Janos Zempleni

Centre for Neuro Skills of California, Bakersfield, USA

University of Nebraska, Lincoln, USA

The new edition of this highly respected text consolidates advances in specific therapeutic approaches for traumatic brain injury. It offers pharmacological, anatomical, and physiological information for basic therapeutic rationales that are not well-understood in the field. Expanding coverage from the last edition, it includes details on metabolic and bioenergetic factors in brain injury, neuroendocrine dysfunction following brain injury, blast injury, ethical issues in treatment of brain injury, interventions for the minimally conscious patient, neuropharmacological and neuropsychological interventions following brain injury, and dietary and exercise considerations after brain injury.

Integrating nutrition with biochemistry, genetics, and physiology, this text presents key concepts in nutrition science, emphasizing the role of macroand micronutrients in metabolism. Revising and expanding information from Advanced Nutrition Micronutrients and Advanced Nutrition Macronutrients, this work by two of the most respected researchers and educators in the field includes new chapters on food intake regulation, daily recommendations, nutrition assessment, metabolism, toxicology, nutrigenomics, epigenetics, gene expression, cell cycle, and lifespan nutrition. Comb-bound to lay flat, it includes a glossary, clinical correlates, and a CD-ROM with additional instructional material.

Catalog no. 71947, ISBN: 978-1-4200-7194-8 May 2010, 7 x 10, 1079 pp. Suggested Price: $159.95 / £99.00

Catalog no. 55526, ISBN: 978-1-4200-5552-8 August 2008, 7 x 10, 552 pp., Soft Cover Suggested Price: $102.95 / £66.99

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Textbook

Edited by

Case Studies in Physiology and Nutrition

Ronald Ross Watson

Lynne Berdanier

University of Arizona, Tucson, USA

Gainesville State College, Georgia, USA

Victor R. Preedy

Carolyn D. Berdanier

Cancer Treatment and Prevention

King’s College London, UK

Professor Emerita, University of Georgia, Athens, USA

A review of the recent surge in research related to the effect of plant products in cancer treatment, Bioactive Foods and Extracts: Cancer Treatment and Prevention organizes cutting-edge findings into an easily accessible format. It addresses the wide availability of botanicals and their extracts and how their use is largely unregulated, particularly in the United States. It provides the sciencebased information critical to researchers and health care professionals charged with making decisions regarding the benefits, risks, and value of botanicals in the prevention and treatment of cancers.

Designed to encourage critical thinking skills, this text of case studies presents a range of conditions including anemia, diabetes, obesity, over- and malnutrition, starvation, parasites, dementia, and vitamin deficiencies. Each study presents patient background, lists symptoms and clinical findings, and poses questions. Another section lists solutions, scientific information, and opportunities for further learning. The text explores nutritional components by defining biochemical, mechanical, and physical functions. The book’s format aids students in relating functionality to system failure as well as understanding the role of environment in health and nutrition.

Catalog no. K10833, ISBN: 978-1-4398-1619-6 November 2010, 7 x 10, 663 pp. Suggested Price: $169.95 / £108.00 Available in eBook

Catalog no. 88777, ISBN: 978-1-4200-8877-9 September 2009, 7 x 10, 176 pp., Soft Cover Suggested Price: $61.95 / £39.99

Textbook

Cereal Grains

Bioactive Peptides Applications for Improving Nutrition and Health Richard Owusu-Apenten University of Ulster, Coleraine, Northern Ireland

This book presents data from human studies and trials, along with recent research findings on the benefits of bioactive peptides used to mitigate major metabolic derangements that result in unwanted weight loss. It covers the background science on the relationship between illness and muscle weight loss, highlighting bioactive peptides’ ability to enhance the body’s antioxidant status, antisepsis capacity, immune function, anti-inflammatory capacity, growth potential, and appetite. Building on this, the author discusses the use of bioactive peptides to modify aspects of the host response to illness, including inflammation, antimicrobial activity, anabolic dysfunction, and anorexia. Catalog no. K10702, ISBN: 978-1-4398-1362-1 June 2010, 6-1/8 x 9-1/4, 414 pp. Suggested Price: $169.95 / £108.00

Properties, Processing, and Nutritional Attributes Sergio O. Serna-Saldivar I.T.E.S.M., Monterrey, Mexico Series: Food Preservation Technology

Focusing on postharvest management and the wide array of industrial processes used to manufacture foods, this text provides current information about the physicochemical and nutritional properties of cereals and their products. It covers the chemistry, physical properties, and morphology of cereal grains and provides a better understanding of the storage and manufacturing processes. The text covers the chemical and physical grain properties of various types of cereals and cerealbased products as well as industrial dry-milling and wet-milling techniques. Catalog no. K10801, ISBN: 978-1-4398-1560-1 May 2010, 6-1/8 x 9-1/4, 752 pp. Suggested Price: $99.00 / £63.99

Available in eBook

Biotechnology in Functional Foods and Nutraceuticals Edited by

Debasis Bagchi University of Houston College of Pharmacy, Texas, USA

CRC Desk Reference for Nutrition

Francis C. Lau

Third Edition

InterHealth Nutraceuticals Incorporated, Benicia, California, USA

Carolyn D. Berdanier

Dilip K. Ghosh

Professor Emerita, University of Georgia, Athens, USA

nutriConnect, Sydney, NSW, Australia

Nutrition Science

Bioactive Foods and Extracts

Written by a team of top-tier researchers and scientists, this resource brings you up to speed on cutting-edge advances taking place in the field. It begins with an overview of recent advances in biotechnology and their contributions to food science. It then examines the impact of genetic modification on functional foods and explores various aspects of food manufacturing technology. The book also provides coverage of quality assurance and food safety and an assessment of where the field currently stands on legal, social, and regulatory aspects of food biotechnology.

This updated reference defines and explains terms commonly used in nutrition, medicine, food science, metabolism, and physiology. The entries are listed alphabetically and are followed by a definition, paragraph, essay, and composition or feature article. Many of the more complex entries are supported with illustrations and/or tables. It has been expanded to reflect new advances in all areas of nutrition science. New material contains information on gut hormones and their functions; food intake recommendations; new drugs with nutritional applications; and novel discoveries of transport proteins and messenger proteins. Websites are provided for additional information.

Catalog no. 87118, ISBN: 978-1-4200-8711-6 April 2010, 7 x 10, 591 pp. Suggested Price: $149.95 / £95.00

Catalog no. K12160, ISBN: 978-1-4398-4844-9 May 2011, 7 x 10, 448 pp. Suggested Price: $99.95 / £63.99

Available in eBook

Available in eBook For more information and a complete list of titles, visit us at www.crcpress.com

Fatty Acids in Health Promotion and Disease Causation Edited by

Principles and Technology Edited by

M. Guo

Ronald R. Watson

University of Vermont, USA

Nutrition Science

This book focuses on heart disease and the role that fatty acids can play in its prevention and causation. It provides information on special populations, Native Americans, stroke, and cardiac injury as examples of areas where fatty acids play a key role. The book also discusses body composition, diabetic disease, health promotion, and actions after transformation by oxidation. It includes coverage of fatty acids in health promotion and diseases such as cancer, intestinal microbes, and membrane functions. Finally the actions of omega-3 fatty acids are extensively investigated by global experts. Catalog no. N10251, ISBN: 978-1-893997-65-3 January 2010, 6 x 9, 865 pp. Suggested Price: $175.00 / £114.00 Available in eBook

Food Constituents and Oral Health Current Status and Future Prospects

Functional foods—products which have health-promoting properties over and beyond their nutritional value—have become a significant food industry sector. This volume provides an authoritative introduction to the key scientific aspects and major product categories in this area. It focuses on the most significant product categories, reviewing ingredient sources, classification, chemical and physical properties, the wide range of therapeutic effects and possible mechanisms of action, among other topics. It also explores industry and consumer roles and examines antioxidants, dietary fiber, prebiotics and probiotics, lipids, and soy. The Appendix contains laboratory exercises. Catalog no. N10083, ISBN: 978-1-4398-0897-9 February 2009, 6 x 9 Suggested Price: $229.95 / £135.00

Handbook of Fermented Functional Foods Second Edition Edited by

Edited by

Edward R. Farnworth

M. Wilson

Agriculture and Agri-Food Canada, St. Hyacinthe, Quebec, Canada Series: Functional Foods and Nutraceuticals

Clemson University, South Carolina, USA / Eastman Dental Institute, UK

Oral diseases can have a significant impact on self esteem and quality of life. This essential collection reviews the latest research into the effects of food constituents on diseases and conditions of the mouth. Chapters cover diseases caused by oral bacteria, viral and fungal infections of the oral cavity, and dental erosion. The book also examines the effects of specific foods and food components, including sugar alcohols, casein phosphopeptides and antioxidants. The final section explores the technology and development of foods and supplements for oral health and oral healthcare products containing food-derived bioactives.

Functional Foods

Catalog no. N10062, ISBN: 978-1-4398-0430-8 June 2009, 6 x 9, 500 pp. Suggested Price: $247.95 / £150.00

Food Lipids Chemistry, Nutrition, and Biotechnology, Third Edition

This second edition examines the health benefits of fermented foods as well as the processes and production techniques involved in their manufacture. It includes new chapters on olives, tempeh, and the traditional fermented foods of China, Thailand, and India. It reveals the specific benefits of fermented milk, Kefir, yogurt, and cheese. Contributions cover fermented soy products, Korean Kimchi and Doenjang, and German sauerkraut. The book also explains the bioactivity and bioavailability of microorganisms and investigates the more recent practice of producing probiotic cultures to add to fermented foods for increased health benefit. Catalog no. 53264, ISBN: 978-1-4200-5326-5 May 2008, 6-1/8 x 9-1/4, 600 pp. Suggested Price: $172.95 / £110.00

Handbook of Nutraceuticals and Functional Foods

Edited by

Second Edition

Casimir C. Akoh

Edited by

The University of Georgia, Athens, USA

Robert E.C. Wildman

David B. Min The Ohio State University, Columbus, USA Series: Food Science and Technology

Demeter Consultants, Dripping Springs, Texas, USA Series: Modern Nutrition

Highlighting the role of dietary fats in foods, human health, and disease, the third edition of Food Lipids emphasizes lipids from the point of entry into the food supply. New chapters cover polyunsaturated lipid oxidation in aqueous systems, total antioxidant evaluation and synergism, tocopherol stability and prooxidant mechanisms of oxidized tocopherols in lipids, and the effects and mechanisms of minor compounds in oil on lipid oxidation. Addressing the chemistry of lipid and antioxidant reactions as well as applications in biotechnology, this edition presents an in-depth discussion on lipid oxidation and antioxidants.

With contributions from a panel of leading international experts, the Handbook of Nutraceuticals and Functional Foods, Second Edition provides a collection of the most current topics in nutraceuticals and functional foods. This edition features new and revised chapters, including the topics of vitamin E, nutritional supplements and inflammation, whey protein, cereals, beverages, and fruits. This authoritative guide serves as a comprehensive, all-in-one reference source for professionals in food chemistry and engineering as well as nutritional, pharmaceutical, and biomedical science and makes an ideal text for students specializing in these fields.

Catalog no. 46632, ISBN: 978-1-4200-4663-2 March 2008, 7 x 10, 928 pp. Suggested Price: $249.95 / £160.00

Catalog no. 6409, ISBN: 978-0-8493-6409-9 October 2006, 7 x 10, 560 pp. Suggested Price: $169.95 / £108.00

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Handbook of Nutrition and Food Second Edition

Handbook of Prebiotics and Probiotics Ingredients Health Benefits and Food Applications

Edited by

Carolyn D. Berdanier and Elaine B. Feldman

Susan Sungsoo Cho

Johanna Dwyer Tufts New England Medical Ctr, Boston, Massachusetts, USA

NutraSource Inc., Laurel, Maryland, USA

Terry Finocchiaro National Starch Food Innovation, Bridgewater, New Jersey, USA

Handbook of Nutrition and Food, Second Edition covers basic nutrition concepts including food composition, labeling, and nutrient analysis systems to provide a solid foundation for understanding the role of individual micronutrients, metabolic issues, as well as nutrient-nutrient interactions and their effects on the body. The book addresses nutritional need throughout the lifecycle from prenatal to old age, as well as the nutritional evaluation and monitoring of specific age and cultural demographics. A considerable portion of the book details clinical nutrition and the prophylactic and therapeutic use of nutrition in a wide variety of disease circumstances.

While there is little dispute that probiotics and prebiotics, alone and together, have been proven to promote gastrointestinal health and proper immune function, the challenge faced by researchers is finding not only the right combinations, but also finding those that are fully compatible with the formulation, processing, packaging, and distribution of functional foods. This volume comprehensively explores these variables and highlights the most current biological research and applications. It examines the sources of prebiotics and probiotics, describes the physiological functions of both products, and discusses promising applications for a plethora of disorders.

Catalog no. 9218, ISBN: 978-0-8493-9218-4 August 2007, 8-1/2 x 11, 1288 pp. Suggested Price: $319.95 / £204.00

Catalog no. 62131, ISBN: 978-1-4200-6213-7 November 2009, 6-1/8 x 9-1/4, 454 pp. Suggested Price: $164.95 / £102.00

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Handbook of Nutrition in the Aged Fourth Edition

Handbook of Vitamins

Edited by

Fourth Edition

Ronald Ross Watson

Edited by

University of Arizona, Tucson, USA Series: Modern Nutrition

Robert B. Rucker, Janos Zempleni, John W. Suttie, and Donald B. McCormick

The Handbook of Nutrition in the Aged reviews health problems that occur in aging adults and the nutritional therapies to overcome them. This fourth edition features new sections on alcohol and beverages in health degradation as well as complementary and alternative medicines, including the use of antioxidants, botanicals, and marine oils. New chapters address arthritis, cognitive functioning, diabetes prevention, cancer, nutritional supplements in fracture care, and recent research on protein and vitamins intake. This text also provides new information on adequate diets to improve quality of life.

Thoroughly revised and updated, Handbook of Vitamins highlights the most recent research in vitamins and gene expression, vitamin-dependent genes, and vitamin effect on DNA stability. This fourth edition includes new chapters on vitamin-dependent modification of chromatin, analysis of vitamin metabolism using accelerated mass spectrometry, and dietary reference intakes for vitamins. It encompasses classical and modern approaches to vitamins, focusing on human nutrition, vitamin analysis, and vitamin action at the molecular level. Featuring contributions from international experts, this remains an ideal reference for nutritional scientists, food scientists, and graduate students.

Catalog no. 59718, ISBN: 978-1-4200-5971-7 October 2008, 7 x 10, 368 pp. Suggested Price: $139.95 / £89.00 Available in eBook

Catalog no. 4022, ISBN: 978-0-8493-4022-2 June 2007, 7 x 10, 608 pp. Suggested Price: $159.95 / £102.00 Available in eBook

Handbook of Prebiotics Edited by

Textbook

Glenn R. Gibson The University of Reading, UK

Introducing Food Science

Marcel B. Roberfroid

Robert L. Shewfelt

Universite Catholique de Louvain, Brussels, Belgium

University of Georgia, Athens, USA

This handbook discusses the concept, definition, and criteria for classification as prebiotics and describes their interactions with gut microbiota. Contributions discuss the biomechanics of prebiotics and their effects on immune status, serum lipid concentrations, mineral bioavailability, and satiety modulation. They consider the health implications of prebiotic intake such as reduced incidence of gastroenteritis and chronic pathogenic gut disorders including intestinal cancers and inflammatory bowel disease. The book explores the varying effects of prebiotics in different populations and age groups and describes potential food avenues and the safety implications for prebiotic use.

This textbook is designed to excite and encourage students to major in food science. It proceeds from a non-technical discussion of food issues that concern today’s consumer to an in-depth technical overview of the basic principles of the study of food. In between are commercial products and processes and the functions and roles of food scientists. Each section builds on the previous one, providing greater technical depth. Depending on the course, professors can choose to use select chapters or all chapters in the book.

Catalog no. 8171, ISBN: 978-0-8493-8171-3 January 2008, 6-1/8 x 9-1/4, 504 pp. Suggested Price: $162.95 / £102.00

Nutrition Science

Professor Emerita, University of Georgia, Athens, USA

Catalog no. TX285, ISBN: 978-1-58716-028-8 April 2009, 6-1/8 x 9-1/4, 385 pp. Suggested Price: $61.95 / £39.99

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Textbook

Nutrients and Epigenetics

Introduction to Nutrition and Metabolism

Edited by

Sang-Woon Choi

Fourth Edition

Jean Mayer USDA Human Nutrition Research Center on Aging, Boston, Massachusetts, USA

David A. Bender

Simonetta Friso

Nutrition Science

University College London, UK

University of Verona School of Medicine, Italy

This fourth edition of a bestseller cut through a wealth of sometimes conflicting new findings to continue to provide a clear introduction to nutrition and metabolism. It explains the scientific principles underlying our current understanding of interactions between diet and health, examines nutrient function and metabolic pathways, and explores the scientific basis of various dietary goals. New features include a list of key points at the end of each chapter and the addition of open-ended case-based problems. The accompanying CD contains PowerPoint® presentations, self-assessment exercises, a virtual laboratory, and a nutrient analysis program.

Presenting up-to-date research on the relationship between nutrition and the evolving field of epigenetics, this work takes a close look at current findings and the potential impact of this research on our understanding of aging, embryonic growth, and the development of cancer. With the aid of numerous color illustrations and photographs, it effectively describes how nutrients modulate physiologic and pathologic processes. Providing a starting point for further research, it covers a range of cutting-edge topics that include current findings on DNA methylation, histone modification, epigenetic phenomena, and chromatin remodeling.

Catalog no. 43129, ISBN: 978-1-4200-4312-9 July 2007, 7 x 10, 440 pp., Soft Cover Suggested Price: $71.95 / £45.99

Catalog no. 63545, ISBN: 978-1-4200-6354-7 May 2009, 6-1/8 x 9-1/4, 258 pp. Suggested Price: $133.95 / £85.00 Available in eBook

Lycopene Nutritional, Medicinal and Therapeutic Properties

Nutrition in Public Health

Edited by

Principles, Policies, and Practice

V.R. Preedy Ronald R. Watson

Arlene Spark Hunter College, New York City, USA

Increasingly, clinical evidence supports the role of lycopene as a nutrient with important health benefits, especially against a broad range of epithelial cancers. The possibility that consumption of lycopene-rich foods may reduce the risk of such diseases has prompted numerous in-depth studies of the levels of lycopene in foods and of correlations between dietary lycopene and certain diseases. This monograph serves as a reference for providing a better understanding of the role of lycopene in promoting health, by encouraging a deeper understanding of approaches to a healthy diet and life.

Catalog no. N00089, ISBN: 978-1-57808-538-5 January 2009, 6 x 9, 472 pp. Suggested Price: $119.95 / £76.99 Available in eBook

Nutrition plays a key role in many conditions, including pre-term delivery, cancer, obesity, diabetes, and cardiovascular and renal diseases. This book focuses on nutrition issues in the public setting, taking into account the myriad demographic, social, and cultural issues that influence public policy. It integrates an examination of food and nutrition needs and the policies and political mechanisms that affect the delivery of quality food and nutrition services. It presents opposing views on controversial, cutting-edge issues such as the conflicting interests of USDA and DHHS, legislation for functional foods, food labeling and health claim regulations, and school feeding challenges. Catalog no. 1473, ISBN: 978-0-8493-1473-5 May 2007, 7 x 10, 576 pp. Suggested Price: $129.95 / £83.99 Available in eBook

Melatonin in the Promotion of Health

Nutrition Support for the Critically Ill Patient

Second Edition

A Guide to Practice

Edited by

Ronald R. Watson

Gail Cresci

University of Arizona, Tucson, USA

Medical College of Georgia, Augusta, USA

This book covers how melatonin is synthesized in the body and how this hormone affects several diseases. The book heavily focuses on prevention as well as treatment of various human disease states including behavior disorders, mental disorders, breast cancer, bone health, and gastrointestinal diseases. It covers the role of melatonin in the prevention of oxidative stress, mutagenesis, sun damage, ocular health, gut motility, and detoxification. It also presents mechanisms of melatonin action in humans including cell modulation, signaling mechanisms, protective effects, and melatonin receptors as well as its role as an antioxidant.

Designed for clinicians working in a critical care setting, this practical text considers the internal alterations that occur during critical illness to provide evidencebased, state-of-the-art practices for nutritional support. Highlighting metabolism issues, nutrient delivery, and lifecycle considerations such as pregnancy and old age, it examines the need for specialized nutrients and explores topics such as physiological stress, specific system failures, and general systemic failure. The text also explores professional issues such as ethical and economic considerations and provides an extensive list of references, tables, figures, and case studies.

Catalog no. K11833, ISBN: 978-1-4398-3979-9 May 2011, 6-1/8 x 9-1/4, 350 pp. Suggested Price: $129.95 / £82.00

Catalog no. 2153, ISBN: 978-0-8493-2153-5 February 2005, 7 x 10, 712 pp. Suggested Price: $144.95 / £92.00

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Nutrition, Physical Activity, and Health in Early Life Second Edition

Nutritional Management of Digestive Disorders Edited by

Obesity Management Centre, Prague, Czech Republic

Chief, Section of Gastroenterology, University of Arizona College of Medicine, Tucson, USA

The second edition of Nutrition, Physical Activity, and Health in Early Life analyzes longitudinal and cross-sectional data on the morphological, nutritional and functional development as related to the environment influencing the growth and development of humans in early life stages. New chapters address the role of genetic factors as well as the prevention, consequences, and treatment of high BMI and obesity. The text compares body mass index, body composition, and the shifts of adiposity rebound on an international scale. The presented approach combines somatic, functional, biochemical, hormonal, and psychological parameters to characterize the level of development.

Reflecting current concerns, especially regarding aging and obesity, this cuttingedge work covers a range of digestive disorders and novel therapies. It considers management and nutrition for celiacs, eosinophilic esophagitis, and inflammatory bowel, as well as acute pancreatitis and liver disease. It discusses macro- and micronutrients for colon cancer prevention, guidelines on probiotics for IBS and antibiotic-associated diarrhea, treatments for obesity including bariatric surgery, and short bowel syndrome and small intestinal transplantation. It also includes a wealth of practical advice on nutritional assessment, parenteral nutrition, and home nutritional support.

Catalog no. 82310, ISBN: 978-1-4200-8231-9 October 2009, 6-1/8 x 9-1/4, 428 pp. Suggested Price: $144.95 / £92.00

Catalog no. 86545, ISBN: 978-1-4200-8654-6 August 2010, 6-1/8 x 9-1/4, 406 pp. Suggested Price: $129.95 / £82.00

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Nutritional Concerns in Recreation, Exercise, and Sport

Obesity

Edited by

Judy A. Driskell

Debasis Bagchi

University of Nebraska, Lincoln, USA

University of Houston College of Pharmacy, Texas, USA

Ira Wolinsky

Harry G. Preuss

Professor Emeritus, University of Houston, Texas, USA

Georgetown University Medical Center, Washington, DC, USA

Concise, current, and well-referenced, this book address major nutritional concerns of athletes, fitness practitioners, and serious recreationalists. It contains a blend of basic and applied chapters that provide recommendations to increase endurance and enhance performance. Topics include energy requirements, the roles of macronutrients and micronutrients, hydration, weight control, dietary supplements as ergogenic aids, and life cycle including aging and pregnancy. Information on nutrient requirements is correlated with age and energy expenditure, encouraging the creation of tailored nutrition plans. Each chapter summarizes practical nutritional recommendations.

This volume is a comprehensive resource for sound, up-to-the-minute data on the management of obesity. Divided into eight sections, the text covers epidemiology and pathophysiology, associated degenerative diseases, drug development and safety, the intricacies of childhood obesity, and the benefits of bariatric surgery. A large portion of the book considers natural, nutritional, and physical approaches to weight management. It explores exercise, diet, and gender differences, along with research on a wide range of functional foods, neutraceuticals, and natural supplements such as hydroxycitric acid, marine lipids, polyphenolic compounds, trivalent chromium, and ephedra.

Catalog no. 68156, ISBN: 978-1-4200-6815-3 June 2009, 6-1/8 x 9-1/4, 368 pp. Suggested Price: $124.95 / £79.99

Catalog no. 3802, ISBN: 978-0-8493-3802-1 March 2007, 7 x 10, 592 pp. Suggested Price: $167.95 / £107.00

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Epidemiology, Pathophysiology, and Prevention

Nutritional Genomics The Impact of Dietary Regulation of Gene Function on Human Disease California State Polytechnic University, Pomona, USA

Postharvest Biology and Technology for Preserving Fruit Quality

Raymond L. Rodriguez

Daniel Valero and Maria Serrano

Edited by

Wayne R. Bidlack University of California, Davis, USA

University of Miguel Hernandez, Orihuela, Spain

Written as a platform for scientists and policy makers to discuss the current status of nutritional genomic research, this book contains the latest findings on the mechanisms underlying diet-genome interactions. It covers information on transforming dietary signals into disease-preventing changes in gene expression, gene-linked networks of chronic disease and cancer, and the role of food science and nutrition to meet individual genomic health needs. The book identifies future directions for research and challenges and opportunities for improving global health and wellness by preventing, delaying, or mitigating chronic diseases with diet.

A comprehensive overview of new postharvest technologies, this book examines the physical, chemical, and nutritional changes that occur during the ripening process. The text focuses on how to maintain both sensorial and nutritional fruit quality parameters as well as how to extend shelf life. The authors present a wide range of technological applications for postharvest strategies, including heat treatments, naturally-occurring compounds, modified atmosphere packaging, non-toxic chemical compounds, and active packaging. The text also discusses the advantages and disadvantages of using cold temperatures during handling, packaging, and storage.

Catalog no. K11975, ISBN: 978-1-4398-4452-6 June 2011, 6-1/8 x 9-1/4, 448 pp. Suggested Price: $139.95 / £89.00

Catalog no. K10140, ISBN: 978-1-4398-0266-3 May 2010, 6-1/8 x 9-1/4, 287 pp. Suggested Price: $139.95 / £89.00

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Nutrition Science

Bhaskar Banerjee

Jana Parizkova

Introduction to Computational Proteomics Serving People with Food Allergies Kitchen Management and Menu Creation Joel Schaefer Allergy Chefs, Inc., Jacksonville, Florida, USA

Nutrition Science / Protein Science

Written for large food service corporations and hotel and restaurant chains to use when training their staff, this book contains information on cooking for and serving those with food allergies in basic terminology, making it suitable for household-use as well. The author provides information on specialty products to enhance menu offerings and reduce liability issues. He also offers ideas on reviewing kitchen procedures to identify ways to prevent cross-contaminations. The book contains tools for cooks, managers, home cooks, and chefs. Catalog no. K11383, ISBN: 978-1-4398-2804-5 April 2011, 6-1/8 x 9-1/4, 192 pp. Suggested Price: $49.95 / £31.99 Available in eBook

Department of Structural Biology, Stanford University, California, USA Series: Chapman & Hall/CRC Mathematical & Computational Biology

This book tackles the steps and problems involved with protein analysis, classification, and meta-organization. It starts with the analysis of individual entities and proceeds to more complex entities, from protein families to interactions, cellular pathways, and gene networks. The first part of the book presents methods for identifying the building blocks of the protein space, algorithms for assessing similarity between proteins, and mathematical models for representing protein families and classifying new instances. The second part covers methods that investigate higher order structure in the protein space through the application of unsupervised learning algorithms. Catalog no. C5556, ISBN: 978-1-58488-555-9 November 2010, 6-1/8 x 9-1/4, 767 pp. Suggested Price: $89.95 / £57.99

Emerging Protein Biotherapeutics Vitamin K in Health and Disease

Edited by

John W. Suttie

Preclinical Therapeutics, Seattle Genetics, Inc., Bothell, Washington, USA

Professor Emeritus, University of Wisconsin-Madison, USA

Vitamin K in Health and Disease provides a comprehensive summary of the latest scientific evidence regarding Vitamin K’s health-promoting activities. This book offers complete coverage of the chemistry of Vitamin K, deficiency signs and nutritional assessment, metabolism and biochemistry, and pharmacology. It presents up-to-date scientific studies on the nutritional, metabolic, and medical aspects along with an overview of the history of Vitamin K research. This text also reviews current dietary requirements and discusses both plasma and non-plasma Vitamin K-dependent proteins.

Golan Yona

Catalog no. 3392, ISBN: 978-0-8493-3392-7 April 2009, 6-1/8 x 9-1/4, 231 pp. Suggested Price: $133.95 / £85.00 Available in eBook

Iqbal S. Grewal Given the speed at which antibody therapy is becoming readily accepted, a comprehensive industry guide is sorely needed. Written by leading international authorities, this book maintains an overall emphasis on various therapeutic approaches and applications and provides critical discussions on the most significant areas of research in biologics. It focuses on the applications of protein biologics in autoimmunity and inflammation, hematological malignancies, and solid tumors. Each chapter clearly presents the most informative and contemporary account of its subject available, making this an unrivaled reference source beneficial to those in both academia and biotechnology industries. Catalog no. 63200, ISBN: 978-1-4200-6320-2 June 2009, 6-1/8 x 9-1/4, 368 pp. Suggested Price: $164.95 / £105.00 Available in eBook

Computational Protein-Protein Interactions Edited by

Ruth Nussinov National Cancer Institute, Frederick, Maryland, USA

Gideon Schreiber Weizmann Institute of Science, Rehovot, Israel

A description of fundamental and applied aspects of the usefulness of computations when approaching protein-protein interactions, this book incorporates different views of the same biochemical problem from sequence to structure to energetics. It covers protein-protein interaction, drug design for inhibition, and uses for predicting function. The text provides an overview of the topic with general chapters understandable by students and junior researchers in this area, while also providing advanced material for more specialized readers. The chapters detail the complexity of protein interaction studies and inform readers of the potential caveats that might be involved. Catalog no. 70053, ISBN: 978-1-4200-7005-7 June 2009, 6-1/8 x 9-1/4, 343 pp. Suggested Price: $124.95 / £79.99

Textbook

Introduction to Peptides and Proteins Ülo Langel, Benjamin F. Cravatt, Astrid Gräslund, Gunnar von Heijne, Tiit Land, Sherry Niessen, and Matjaˇz Zorko This book provides key insight into the fast-developing field of proteomics, including structural and functional aspects, biochip development, and clinical potential. It includes chapters on bioinformatics and proteomics and presents the latest information on concerns over protein degradation and the post-translational modifications of proteins and peptides. The book also includes a section on protein-coupled diseases that presents increasing evidence of the pathological impact of protein misfolding in relation to various neurodegenerative diseases, as well as a section on the role of proteins in cancer. Catalog no. 64126, ISBN: 978-1-4200-6412-4 November 2009, 6-1/8 x 9-1/4, 420 pp. Suggested Price: $102.95 / £65.99

Available in eBook For more information and a complete list of titles, visit us at www.crcpress.com

Edited by

Renata Pasqualini and Wadih Arap University of Texas, M.D. Anderson Cancer Center, Houston, USA Series: Drug Discovery Series

Featuring contributions from leading experts, Protein Discovery Technologies provides comprehensive coverage of the principles, techniques, strategies, and broad range of applications of protein discovery. This volume presents in-depth discussions of various methods for protein discovery, including bioinformatics, interaction cloning, protein purification, phage display, non-primate models, and chemical targeting. It also explores biological themes through the examination of cell death, angiogenesis, hemostasis, development, signal transduction, transcriptional control, cell cycle control, neurobiology, and quality control. Catalog no. DK2081, ISBN: 978-0-8247-5468-6 July 2009, 6-1/8 x 9-1/4, 250 pp. Suggested Price: $154.95 / £99.00 Available in eBook

Structure and Function of Intrinsically Disordered Proteins Peter Tompa Hungarian Academy of Sciences, Budapest

Providing the first focused and detailed treatment of the rapidly emerging field of protein disorder, this book illustrates how IDPs defy the structure-function paradigm and play important regulatory and signaling roles. The author introduces basic terms and fundamental principles of protein science and presents a unified theory of ordered and disordered proteins. He also outlines new applications of traditional biophysical and bioinformatic techniques, such as x-ray crystallography and NMR. The book includes an overview of the structure, function, and evolution of IDPs and addresses biomedical implications and protein disorder in drug development for cancer and neurodegenerative diseases. Catalog no. C7892, ISBN: 978-1-4200-7892-3 November 2009, 6-1/8 x 9-1/4, 359 pp. Suggested Price: $102.95 / £65.99 Available in eBook

Edited by

The Chemical Components of Tobacco and Tobacco Smoke

Sheldon J. Park

Alan Rodgman

State University of New York at Buffalo, USA

Winston-Salem, North Carolina, USA

Jennifer R. Cochran

Thomas A. Perfetti

Stanford University, California, USA

Perfetti and Perfetti, LLC, Winston-Salem, North Carolina, USA

The emerging use of the computational design approach as a means of engineering proteins with novel functions has led to widespread usage of computational analysis in protein engineering at large. This book furthers understanding in this design area by providing a lucid description of computation’s role in protein engineering and tracing the history of protein design. In so doing, it successfully de-mystifies computational analysis, making it widely accessible to a broad audience both in academia and industry.

Cataloging more than 8,400 tobacco and tobacco smoke components, this book provides the most comprehensive, single-source reference published on the subject since 1968. It reviews every chemical class of component found in tobacco and tobacco smoke and presents more than 6,000 cited references that deal with many topics pertinent to the ones in question. The authors list the corresponding Chemical Abstracts Registry Number for those most cataloged. They also examine health-related problems assigned to specific tobacco smoke components as well as components reported to negate such harmful effects. The accompanying CD-ROM contains a searchable, 300-page alphabetical index.

Protein Engineering and Design

Catalog no. 76582, ISBN: 978-1-4200-7658-5 September 2009, 6-1/8 x 9-1/4, 416 pp. Suggested Price: $124.95 / £79.99 Available in eBook

Catalog no. 78836, ISBN: 978-1-4200-7883-1 December 2008, 8-1/2 x 11, 928 pp. Suggested Price: $319.95 / £204.00 Available in eBook

Proteins Energy, Heat and Signal Flow Edited by

Endocrine Disruption Modeling

David M. Leitner

Edited by

University of Nevada, Reno, USA

James Devillers

John E. Straub

CTIS, Rillieux La Pape, France Series: QSAR in Environmental and Health Sciences

Boston University, Massachusetts, USA

This comprehensive, up-to-date volume presents state-of-the-art computational strategies for studying energy redistribution, signaling, and heat transport in proteins and other molecular machines, including nanoscale and biomolecular systems. It emphasizes the interrelations between these disparate approaches that have contributed to our understanding of energy flow in proteins and its role in protein function. By defining the forefront of research in this area, the book delineates the current challenges and opportunities in developing novel methods and applications for the evolving study of energy flow in molecular machines and nanomaterials. Catalog no. 87037, ISBN: 978-1-4200-8703-1 September 2009, 6-1/8 x 9-1/4, 415 pp. Suggested Price: $133.95 / £85.00

This book provides an excellent overview of approaches for modeling the endocrine activity of chemicals and the related potential adverse effects they may induce on environmental and human health. It focuses on chemicals accidentally released into the environment and also on the specific design, in agro-chemistry, of chemicals acting on the endocrine system of insects to control them. An interesting feature of the book is the bringing together of these two aspects of endocrine disruption, which are based on the same modeling concepts. It includes a review of available e-resources. Catalog no. 76353, ISBN: 978-1-4200-7635-6 April 2009, 6-1/8 x 9-1/4, 416 pp. Suggested Price: $144.95 / £92.00 Available in eBook

Available in eBook For more information and a complete list of titles, visit us at www.crcpress.com

Protein Science / Toxicology

Protein Discovery Technologies

Environmental Effects on Seafood Availability, Safety, and Quality Edited by

West Pomeranian University of Technology, Poland

Handbook of Venoms and Toxins of Reptiles

Bonnie Sun Pan

Edited by

National Taiwan Ocean University, Taiwan Series: Chemical & Functional Properties of Food Components

Stephen P. Mackessy

This 12th volume in the Chemical & Functional Properties of Food Components series focuses on the effects of natural and anthropogenic environmental conditions on the availability of marine organisms harvested for food purposes. Particular emphasis is placed on how physical, chemical, and biological characteristics of the marine environment impact technological suitability, sensory quality, nutritional value, health-promoting activity, and safety aspects of raw seafood materials. The authors explain how to enhance the desirable sensory quality and health effects of various marine food products. The text also explores the health risks and benefits of consuming seafood.

Bringing together contributions from many of the world’s leading experts in toxinology, this handbook covers a broad range of topics relevant to a wide range of professionals including clinicians, biomedical researchers, herpetologists, and zoologists, as well as pharmacologists and evolutionary scientists. It discusses phylogeny and gland structure, venom enzymes and toxins, non-protein venom components, and envenomation and its treatment. It contrasts ideal treatments with those that are actually available in specific areas of the world. The text also addresses venom enzymes and assay procedures used to detect venoms along with venom toxins.

Catalog no. K10184, ISBN: 978-1-4398-0327-1 December 2010, 6-1/8 x 9-1/4, 401 pp. Suggested Price: $169.95 / £108.00

Catalog no. 9165, ISBN: 978-0-8493-9165-1 July 2009, 7 x 10, 528 pp. Suggested Price: $129.95 / £82.00

Available in eBook

Elzbieta G. Daczkowska-Kozon

Toxicology

Instrumental Data for Drug Analysis

Fire Toxicity

Third Edition - Six Volume Set

Edited by

Terry Mills, III, James Conrad Roberson, Christian C. Matchett, Mathew J. Simon, Mark D. Burns, and Robert J. Ollis, Jr.

Anna Stec and Richard Hull University of Central Lancashire, UK

Assessment of toxic effects is increasingly recognized as key in the assessment of fire hazards. This is the first substantive reference on fire toxicity and the only scientific work on the subject in the last 15 years. This book discusses types of toxic effluents that fires produce, their physiological effects, methods for generation and assessment of fire toxicity, current and proposed regulations, and approaches to modeling the toxic impact of fires. Contributors represent an international team of leading experts in each aspect of this challenging field.

University of Northern Colorado, Greeley, USA

Catalog no. N10161, ISBN: 978-1-4398-2791-8 April 2010, 6 x 9, 664 pp. Suggested Price: $269.95 / £170.00

Finding detailed information on the analysis of drug-related compounds is challenging at best. This latest edition is an extensive six-volume set that contains over 6,500 spectra on more than 1,750 illicit and prescription drugs. It presents data on the six most popular analytical techniques used today: ultraviolet (UV) spectroscopy, infrared (IR) spectrometry, nuclear magnetic resonance (NMR) spectrometry, mass spectrometry (MS), gas chromatography (GC), and high pressure liquid chromatography (HPLC). This edition also presents the latest analytical techniques of FT-Ramen Spectra. Drugs are alphabetized and a combined index permits easy reference. Catalog no. 1974, ISBN: 978-0-8493-1974-7 August 2005, 8-1/2 x 11, 4688 pp. Suggested Price: $1360.00 / £866.00 Available in eBook

Handbook of Forensic Toxicology for Medical Examiners D. K. Molina, M.D.

International Poisonous Plants Checklist An Evidence-Based Reference D. Jesse Wagstaff

Series: Practical Aspects of Criminal & Forensic Investigations

United States Food and Drug Administration (Emeritus)

Forensic professionals require quick and easy access to reliable sources of information to help interpret toxicology results. This volume is a concise handbook referencing the most common toxic drugs and their levels of toxicity, making it an ideal text for quick confirmation in the field or in the lab. It describes how to obtain and submit samples, explains methods of analysis, provides hundreds of tables and data sets on substances causing toxicity that are commonly seen in forensic practice, and includes several appendices, including one on the latest issues in pharmacogenetics pertinent to forensic investigation.

International Poisonous Plants Checklist: An Evidence-Based Reference addresses the geographic fragmentation of and confusion in the poisonous plant literature. It provides an international, authoritative, and comprehensive reference for toxicologists needing information on the human and animal toxicity of plants. Using accepted botanic names, it defines the set of toxic vascular plants of the world, thereby satisfying the need for an international standard of identity. Synonyms and common names are cross referenced with the botanic names for easy reference.

Catalog no. 76418, ISBN: 978-1-4200-7641-7 July 2009, 6-1/8 x 9-1/4, 384 pp., Soft Cover Suggested Price: $92.95 / £58.99

Catalog no. 62522, ISBN: 978-1-4200-6252-6 July 2008, 8-1/2 x 11, 464 pp. Suggested Price: $154.95 / £99.00

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Jet Fuel Toxicology Edited by

University of Arizona School of Medicine, Tucson, USA

Errol Zeiger

Advances in Food Biochemistry

NIEHS, Chapel Hill, North Carolina, USA

Edited by

Glenn D. Ritchie

Fatih Yildiz

Central Nervous System Safety Pharmacology, Columbus, Ohio, USA

Middle East Technical University, Ankara, Turkey

Used by the National Center for Toxological Research in their work with the Gulf Coast oil spill, this book presents current research conducted primarily by the airforce on the toxic effects of JP-8 jet fuel on the pulmonary, immune, dermal, and nervous systems. It examines the history and chemistry involved with the handling of jet fuel, and discusses the impact of exposure. The book considers 13 toxicology studies of significance, the results of which are currently shaping US armed services policy. It will enable all of the hydrocarbon industry to make better choices regarding fuel handling.

Understanding the biochemistry of food is basic to all other research and development in the fields of food science, technology, and nutrition. This volume provides a unified exploration of foods from a biochemical perspective. Featuring illustrations to elucidate molecular concepts throughout the text, it examines a range of issues on the food spectrum, including water and its relation to food, the glycobiology of food components, enzymes, hormones, functional foods and supplements, flavor compounds, organic acids, environmental issues, oxidation, food safety, and the genetic makeup of individual food components.

Catalog no. 80202, ISBN: 978-1-4200-8020-9 July 2010, 6-1/8 x 9-1/4, 348 pp. Suggested Price: $159.95 / £99.00

Catalog no. 7499, ISBN: 978-0-8493-7499-9 December 2009, 7 x 10, 521 pp. Suggested Price: $174.95 / £111.00

Available in eBook

Mixture Toxicity Linking Approaches from Ecological and Human Toxicology Edited by

Cornelis A. M. van Gestel, Martijs Jonker, Jan E. Kammenga, Ryszard Laskowski, and Claus Svendsen Although the fields of toxicology and human health assessment address similar problems, the experts from these fields do not meet very frequently. Originating from a meeting of scientist in both fields, this book clearly links ecotoxicology and classic human toxicology. It incorporates extensive reviews of exposure to toxicants, toxicokinetics and toxicodynamics, toxicology of mixtures, and risk assessment. This unusual combination of coverage sets it apart from other ecotoxicological and risk assessment resources that do not discuss these topics in an integrated manner. Catalog no. K11470, ISBN: 978-1-4398-3008-6 November 2010, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $119.95 / £76.99 Available in eBook

Application of Solution Protein Chemistry to Biotechnology Roger L. Lundblad Lundblad Biotechnology, Chapel Hill, North Carolina, USA

Protein scientist Roger Lundblad draws from traditional protein science and proteomics to include a great deal of material not found in electronic format. He includes chapters on the use of classical protein chemistry in food, the protein and carbohydrate chemistry of adhesives, glues, and sealants, protein chemistry and hydrogels, and the use of chemical modification to prepare protein therapeutics. While demonstrating current uses and development of biotech applications, Dr. Lundblad makes a point to separate what is truly new from that which has merely been renamed. Catalog no. 73419, ISBN: 978-1-4200-7341-6 May 2009, 6-1/8 x 9-1/4, 456 pp. Suggested Price: $174.95 / £111.00 Available in eBook

Reversibility of Chronic Degenerative Disease and Hypersensitivity Volume 1: Regulating Mechanisms of Chemical Sensitivity William J. Rea Environmental Health Center, Dallas, Texas, USA

Kalpana Patel

Basic Organometallic Chemistry Concepts, Syntheses, and Applications of Transition Metals BD Gupta Department of Chemistry, IIT, Kanpur

A J. Elias

Allergy and Environmental Health Center WNY, Buffalo, New York

Department of Chemistry, IIT, Delhi

Offering a perspective on chronic degenerative diseases that disputes the idiopathic label and irreversible prognosis attached to most, this encyclopedia demonstrates that common to chronic diseases is the disruption of systemic and cellular homeostasis, especially by environmental pollutants. Drawing on data collected by the authors in their medical practices, Volume 1 offers an overview of the physiologic basis of homeostasis, exploring how the body deals with toxins, communicates news of assault, and makes provisions for adaptation. The text provides clinicians and researchers with approaches for developing efficient ways to prevent and reverse conditions considered intractable.

Filled with detail not often found in coverage of the chemistry involved with transition metals, this clearly written resource encourages enhanced interest in the study of organometallic chemistry. Among a wealth of topics it covers the 18 Valence Electron Rule, unique reactions in organometallic chemistry, bioorganometallic chemistry, relevant ligands, bonding, structures, and a variety of other reactions, processes, and applications essential to understanding this highly complex field. The text includes figures, equations, and a large number of problems and exercises at the end of each chapter.

Catalog no. K10689, ISBN: 978-1-4398-1342-3 June 2010, 7 x 10, 594 pp. Suggested Price: $139.95 / £73.99

Toxicology / Biochemistry

Mark L. Witten

Catalog no. K12252, ISBN: 978-1-4398-4968-2 September 2010, 7 x 10, 512 pp. Suggested Price: $89.95 / £57.99

Available in eBook For more information and a complete list of titles, visit us at www.crcpress.com

Bioactive Natural Products Detection, Isolation, and Structural Determination, Second Edition Edited by

Steven M. Colegate CSIRO/Plant Toxins Unit, Division of Animal Health, Geelong, Australia

Russell J. Molyneux Western Regional Research Center, Albany, California, USA

Biochemistry

Following the successful format of the original, this new edition presents applications of the most recent techniques for the detection, isolation, and structural determination of bioactive natural products. It features new case studies and illustrations that demonstrate applications of techniques covered in the book. Complementing as much as replacing the first edition, most of the contributors are new. The text includes updates on chemical extraction, NMRbased structure determination, and new contributions on liquid chromatography linked with mass and NMR spectroscopy, dereplication approaches, assessment of source material for natural products, and novel bioassay development. Catalog no. 7258, ISBN: 978-0-8493-7258-2 December 2007, 7 x 10, 624 pp. Suggested Price: $226.95 / £145.00 Available in eBook

Physical, Chemical, and Biological Functions and Properties Edited by

John T. Landrum Florida International University, Miami, USA

Carotenoids are of great interest due to their essential biological functions in both plants and animals, and their properties and functions in natural systems are surprisingly complex. With an emphasis on the chemical aspects of these compounds, this text presents a broad overview and recent developments with respect to understanding carotenoid structure, electronic and photochemical properties, and the use of novel analytical methods in the detection and characterization of carotenoids and their actions. The text also explores LC/MS and LC/MS/MS techniques and new applications of PCR and molecular biology methodologies. Catalog no. 52306, ISBN: 978-1-4200-5230-5 December 2009, 7 x 10, 568 pp. Suggested Price: $195.95 / £125.00 Available in eBook

Textbook

Biochemical Applications of Nonlinear Optical Spectroscopy

Carotenoids

Chemistry for the Life Sciences Second Edition Raul Sutton

Edited by

University of Wolverhampton, UK

Vladislav V. Yakovlev

Bernard Rockett

University of Wisconsin, Milwaukee, USA Series: Optical Science and Engineering

Peter G. Swindells

Nonlinear optical spectroscopy is a powerful tool for studying biomolecular structures and cellular organelles. Written by an international panel of experts, this volume presents the most significant advances and future directions within this important field. It provides an understanding of the nonlinear optical response of complex molecules and reviews developments in ultrafast technology. In addition, the editor includes a theoretical analysis of nonlinear optical spectroscopies. Novel experimental approaches, such as spatial and temporal pulse shaping, are addressed as well as various nonlinear optical spectroscopic tools, including harmonics generation and Raman spectroscopy. Catalog no. 68598, ISBN: 978-1-4200-6859-7 June 2009, 6-1/8 x 9-1/4, 290 pp. Suggested Price: $154.95 / £99.00

Formerly of University of Wolverhampton, UK Retired

Retaining its original user-friendly style, this updated edition continues to provide a foundation in the aspects of chemistry that developing life scientists need to understand biochemical and biomedical research. This edition adds new chapters, including one on water, covering the mole concept and colloids; another on gases, discussing pressure, solubility, and diffusion; and a third on metals, describing properties, carriers, biocatalysis, and toxicity. Each topic is clearly tied to numerical considerations and core concepts. Critical information is reinforced through worked examples and questions. A solutions manual is available upon qualifying course adoption.

Available in eBook

Catalog no. 69357, ISBN: 978-1-4200-6935-8 November 2008, 7 x 10, 280 pp., Soft Cover Suggested Price: $41.95 / £27.99

Biomolecular EPR Spectroscopy

Chemistry of Biomolecules

Wilfred Raymond Hagen

S.P. Bhutani

Delft University of Technology, The Netherlands

Rajdhani College, University of Delhi, India

Biomolecular EPR spectroscopy is widely used for the structural, functional, and analytical analysis of paramagnetic molecules in the biochemistry of all species and in related fields. This volume presents comprehensive, up-to-date coverage of the theory of spectroscopy and its applications to biological systems. The underlying quantum mechanics is introduced, assuming no previous knowledge but offering rigorous treatment. The author provides practical tricks and recommendations based on his 30 years of experience in the field. The text also includes supporting software with simple graphical user interfaces to allow readers to tackle most of the problems faced in spectral analysis.

Biomolecules are molecules that are involved in the maintenance and metabolic processes of all living organisms. Ideal for graduate students and researchers, Chemistry of Biomolecules offers extensive coverage of important biomolecules from an organic chemistry point of view. The esteemed author discusses carbohydrates, amino acids, peptides, proteins, enzymes, pyrimidines, purines, nucleic acids, terpenoids, and lipids. He describes the various topics in simple, lucid language and explains the mechanisms of the reactions wherever required.

Catalog no. 59572, ISBN: 978-1-4200-5957-1 December 2008, 6-1/8 x 9-1/4, 248 pp. Suggested Price: $149.95 / £96.00

Catalog no. N10258, ISBN: 978-1-4398-3929-4 September 2010, 6 x 9, 300 pp. Suggested Price: $99.95 / £63.99

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Nilashis Nandi

Roger L. Lundblad

University of Kalyani, India

Lundblad Biotechnology, Chapel Hill, North Carolina, USA

The active sites of large biological macromolecules greatly accelerate biological reactions. The chirality of the reactants also has a strong influence on the process, but its importance in such biological reactions has only recently begun to be understood. This book explores the influence of chirality on reaction mechanisms in such biological nanospaces. The text addresses the influence of the chirality of amino acid and sugar in the active sites of transferase, oxidoreductases, hydrolases, lysases, isomerase, ligases, and other systems. It also covers ribosomal architecture.

A comprehensive assessment of biomarkers, this book covers the history and current status of the application of biomarkers in diagnostics and prognostics. It explores the technology used for the study of biomarkers, and the validation of biomarkers including a comparison of the various technologies used to identify and measure biomarkers. The author emphasizes the technology underlying biomarkers and the translation of basic science to clinical laboratory technology, including the commercial development of biomarkers. He also covers proteomics and proteomic technologies and their applications in the identification of biomarkers.

Catalog no. K11852, ISBN: 978-1-4398-4002-3 June 2011, 6-1/8 x 9-1/4, 232 pp. Suggested Price: $119.95 / £76.99 Available in eBook

Catalog no. K11042, ISBN: 978-1-4398-1979-1 October 2010, 6-1/8 x 9-1/4, 297 pp. Suggested Price: $149.95 / £95.00 Available in eBook

Chitin, Chitosan, Oligosaccharides and Their Derivatives Biological Activities and Applications Edited by

Se-Kwon Kim

Handbook of Aqueous Solubility Data Second Edition Samuel H. Yalkowsky, University of Arizona, Tucson, USA Yan He, Sanofi-Aventis, Bridgewater, New Jersey, USA Parijat Jain

Pukyong National University, Busan, South Korea

Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA

Providing comprehensive coverage of the biological activities and industrial applications of Chitin, Chitosan, oligosaccharides, and their derivatives, this book presents a balance of information between the various materials, functionalities, applications, and advantages of these polysaccharides in food, nutrition, and agriculture. Divided into five parts, the first part focuses on source and production. The second, third, and fourth parts cover physical and chemical aspects, structural modifications and functions, and biological activities and mechanisms of action. The final part presents a comprehensive assessment of applications.

The second edition of this landmark volume continues the tradition of providing an extensive compilation of published aqueous solubility data for a wide variety of organic nonelectrolytes and unionized weak electrolytes. It adds 2000 new solubility values, bringing the total count to over 18,000 data points for more than 4000 organic compounds. It includes data for pharmaceuticals, pollutants, nutrients, herbicides, pesticides, and agricultural, industrial, and energy-related compounds. Each compound is identified by a sequential number along with molecular formula, compound name, synonyms, molecular weight, CASR number, melting point, and boiling point, if available.

Catalog no. K10823, ISBN: 978-1-4398-1603-5 July 2010, 7 x 10, 666 pp. Suggested Price: $189.95 / £121.00

Catalog no. K10130, ISBN: 978-1-4398-0245-8 April 2010, 7 x 10, 1620 pp. Suggested Price: $399.95 / £254.00

Also Available in Soft Cover and in eBook

Available in eBook

Copper Amine Oxidases Structures, Catalytic Mechanisms and Role in Pathophysiology Edited by

Hansen Solubility Parameters

Giovanni Floris University of Cagliari, Italy

A User’s Handbook, Second Edition

Bruno Mondovi

Charles M. Hansen

University of Rome, La Sapienza, Italy

Charles M. Hansen Consulting, Hoersholm, Denmark

Although the amount of research on copper amine oxidases has grown rapidly and substantially in the past decade, the field unfortunately suffers from lack of cohesion. This book describes the structure of the enzymes, the role of copper, and the unusual cofactor 6-hydroxydopa quinine derived from a posttranslational modification of a tyrosine residue. It also covers the differences in amine oxidases from bacteria, plants, and mammals. Finally, the text examines the importance of this ubiquitous class of enzymes in physiology and in metabolism of biogenic amines.

In this new edition, Charles M. Hansen invites five renowned experts to share their innovative work on novel topics such as using statistical thermodynamics to confirm existing HSPs, reconciling HSP with other thermodynamic theories, predicting the behavior of carbon dioxide, environmental stress cracking, absorption and diffusion in polymers, and other insight on future applications in biological materials, controlled release, nanotechnology, and self-assembly. The book highlights recent findings on interactions with DNA, and other novel applications of HSPs, such as ozone-safe solvents, protective clothing, drug delivery systems, and petroleum applications.

Catalog no. 76809, ISBN: 978-1-4200-7680-6 June 2009, 6-1/8 x 9-1/4, 374 pp. Suggested Price: $154.95 / £99.00 Available in eBook

Biochemistry

Reactions in Active Sites

Development and Application of Biomarkers

Chirality in Biological Nanospaces

Catalog no. 7248, ISBN: 978-0-8493-7248-3 June 2007, 7 x 10, 544 pp. Suggested Price: $179.95 / £114.00 Available in eBook

For more information and a complete list of titles, visit us at www.crcpress.com

Textbook

Insect Physiology and Biochemistry

Textbook

Second Edition

An Acid—Base Approach

James L. Nation

Michael Smith

Biochemistry

University of Florida, Gainesville, USA

University of Connecticut, Storrs, USA

Based on nearly 40 years of teaching, this new edition of a bestselling text presents new findings that challenge conventional wisdom and considers their impact across species. It features new chapters on insect immunity, insect flight, insect vision, and diapause in insects, and includes updated and additional information on insect hormones and development. Providing a clear description of the principles, fundamentals, and terminology of insect physiology, this comprehensive resource offers an in-depth discussion of the relationship between insect physiology and animal behavior and ecology.

Most reactions in organic chemistry can be explained by variations of fundamental acid–base concepts. Using several techniques to develop a relational understanding, this text helps students fully grasp the concepts at the root of organic chemistry. Chapters contain checklists of what students need to know before they begin to study a topic, concepts to be fully understood before moving to the next subject area, homework problems directly tied to each concept at the end of each chapter, embedded problems with answers throughout the material, and experimental details and mechanisms for key reactions.

Catalog no. 61771, ISBN: 978-1-4200-6177-2 April 2008, 7 x 10, 560 pp. Suggested Price: $83.95 / £46.99

Catalog no. 79204, ISBN: 978-1-4200-7920-3 October 2010, 7 x 10, 1592 pp. Suggested Price: $139.95 / £59.99

Liquid Chromatography-Mass Spectrometry Third Edition

Organic Chemistry

Organic Chemist’s Desk Reference

Wilfried M.A. Niessen

Second Edition

hyphen MassSpec Consultancy, Leiden, The Netherlands Chromatographic Science Series

Caroline Cooper

Offering well-rounded coverage of the most significant technological developments in the past few years, this classic work explains how to use LC–MS and interpret data for various disciplines. This edition places a stronger emphasis on applications, dedicating more than two-thirds of the text to examining LC– MS in emerging application areas, including environmental, food-safety, and clinical analysis as well as proteomics, pharmaceutical drug discovery, and natural products research. Supported by the most authoritative literature available, each chapter examines how the strategies, technologies, and recent advances in LC– MS continue to shape these fields.

Extensively revised, this new edition of a classic reference contains the very latest data that chemists need access to for experimentation and research. Changes to the second edition include rearranged content, making subjects easier to find; expanded topics from the glossary now presented as separate chapters; updated information on classic subjects such as mass spectrometry and infrared, ultraviolet, and nuclear magnetic resonance spectroscopy; new sections on chiral separations and crystallography; and cross references to a plethora of web information.

Catalog no. DK2272, ISBN: 978-0-8247-4082-5 August 2006, 6 x 9, 632 pp. Suggested Price: $194.95 / £127.00

London, UK

Catalog no. K10587, ISBN: 978-1-4398-1164-1 July 2010, 7 x 10, 280 pp., Soft Cover Suggested Price: $79.95 / £48.99 Available in eBook

Available in eBook

Handbook of Biochemistry and Molecular Biology Fourth Edition - CD-ROM Version

Omega-3 Fatty Acids and the DHA Principle

Edited by

Raymond C. Valentine and David L. Valentine

Fiona Macdonald

University of California, Santa Barbara, USA

The physical-chemical properties of the omega-3 fatty acid DHA enable it to facilitate biochemical processes in the membrane. This effect has numerous benefits, yet DHA also carries risks that can lead to cellular death and disease. This volume explores the roles of omega-3 fatty acids in cellular membranes and develops a principle by which to assess their benefits and risks. Reflecting the increased public interest that has emerged over the years, the book uses an integrative approach to explain the complex roles of omega-3s in the membrane. Catalog no. K10660, ISBN: 978-1-4398-1299-0 December 2009, 6-1/8 x 9-1/4, 278 pp. Suggested Price: $164.95 / £102.00 Available in eBook

Roger L. Lundblad Lundblad Biotechnology, Chapel Hill, North Carolina, USA CRC Press, Boca Raton, Florida, USA

This revised CD-ROM version of a venerable handbook gathers information not easily obtained from any single reference source. It provides basic and updated information on proteins, nucleic acids, lipids, and carbohydrates. Presented in an organized, concise, and simple-to-use format, this popular reference allows quick access to the most frequently used data. It covers a wide range of topics including amino acids, peptides, synthetic poly acids, vitamins, coenzymes, proteomics, genomics, and cell biology, as well as physical and chemical data. It also details the properties of commonly used biochemicals and laboratory solvents. Catalog no. 8744, ISBN: 978-0-8493-8744-9 May 2010, 1264 pp., CD-ROM Suggested Price: $199.95 / £127.00

For more information and a complete list of titles, visit us at www.crcpress.com

Principles and Practice of Bioanalysis Second Edition

Advanced Textiles for Wound Care

Edited by

Richard F. Venn

S. Rajendran

Pfizer Central Research, Kent, UK

University of Bolton, UK

Principles and Practice of Bioanalysis: Second Edition provides an updated guide to the techniques currently used in developing and running ultra-trace analyses for drugs, metabolites and other substances. Experts in the field offer a logical path through the problems of small molecule bioanalysis, enabling researchers to choose the appropriate methods of analysis across a number of fields, including the agrochemical and pharmaceutical industries. Scientists and graduate students in biology, biochemistry, and chemistry will also find this to be a valuable reference.

This collection provides a detailed explanation of the importance and suitability of using textiles on different wound types. It introduces wound care and covers wound management and the importance of laboratory testing in relation to wound care. It comprehensively reviews the different textile dressings available, moist would management, and bioactive dressings to promote healing. The concluding chapters describe how advanced textiles, such as smart temperature controlled textiles and composites, can be used for wound care products. The final chapter gives an interesting insight into the use of fibrous scaffolds for tissue engineering.

Catalog no. 3857, ISBN: 978-0-8493-3857-1 February 2008, 7 x 10, 344 pp. Suggested Price: $94.95 / £60.99 Also Available in Soft Cover

Signaling Mechanisms of Oxygen and Nitrogen Free Radicals Igor B. Afanas’ev All-Union Vitamin Research Institute, Moscow, Russia

The text covers free radical signaling processes catalyzed by enzymes and examines those producers of superoxide and nitric oxide that are able to use produced ROS/ RNS as signaling species to initiate the processes. It also considers ROS/ RNS signaling produced or insufficiently produced by mitochondrial enzymes, which leads to key findings about mitochondrial disorders and subsequent apoptosis, as well as the development of potential new treatments including novel drugs for aging-related afflictions such inflammation, cancer, and cardiovascular disease. Catalog no. 73745, ISBN: 978-1-4200-7374-4 June 2009, 6-1/8 x 9-1/4, 220 pp. Suggested Price: $164.95 / £105.00 Available in eBook

Catalog no. WP9489, ISBN: 978-1-4200-9489-3 June 2009, 6-1/8 x 9-1/4, 384 pp. Suggested Price: $222.95 / £135.00

Biobased Surfactants and Detergents Synthesis, Properties, and Applications Edited by

Douglas Hayes, Dai Kitamoto, Daniel Solaiman, and Richard Ashby Today’s petroleum prices and supply concerns have led to increased interest in biobased surfactants and detergents, which can out-perform synthetic, petroleumderived surfactants in areas related to biodegradability, biocompatibility, and sustainability. This book provides an overview of biobased surfactants currently under development, exploring R&D in the industrial sector. Several chapters describe the state-of-the-art in biosurfactants and natural amphiphiles synthesized by microorganisms. An additional focus area is on the application of biobased surfactants as lung surfactants. Many chapters involve the chemical and enzymatic synthesis and applications consisting of polyols derived from nature. Catalog no. N10253, ISBN: 978-1-893997-67-7 January 2010, 6 x 9, 515 pp. Suggested Price: $225.00 / £146.00 Available in eBook

Water and Life The Unique Properties of H20 Edited by

Biointegration of Medical Implant Materials Science and Design

Ruth M. Lynden-Bell, Simon Conway Morris, John D. Barrow, John L. Finney, and Charles L. Harper Jr.

Edited by

This collection focuses on the properties of water and its interaction with life. Providing an overview of the role of water in biochemistry, physical chemistry, earth sciences, and astronomy, the book examines the arguments of Lawrence J. Henderson and other scholars on the “fitness” of water for life as part of the physical and chemical properties of nature. Highly esteemed researchers from multidisciplinary fields develop a variety of approaches that help to illuminate ways in which to address deeper questions with respect to the nature of the universe and our place within it.

This volume provides a review of recent research into material and tissue interaction and integration. The first section discusses soft tissue biointegration with chapters on the biocompatibility of engineered stem cells, corneal tissue engineering, and vascular grafts. The second part reviews techniques in drug delivery, including inorganic nanoparticles for targeted drug delivery and alginatebased drug delivery devices. The third section covers design considerations, exploring biocompatibility of materials and its relevance to drug delivery and tissue engineering, mechanisms of failure of medical implants during long term use, and rapid prototyping in biomedical engineering.

Catalog no. K10200, ISBN: 978-1-4398-0356-1 May 2010, 7 x 10, 396 pp. Suggested Price: $89.95 / £57.99 Available in eBook

C.P. Sharma Sree Chitra Tirunal Institute for Medical Sciences and Technology, India

Catalog no. N10181, ISBN: 978-1-4398-3064-2 August 2010, 6 x 9, 384 pp. Suggested Price: $229.95 / £146.00

For more information and a complete list of titles, visit us at www.crcpress.com

Biochemistry / Biomaterials & Medical Devices

Textbook

Biological and Biomedical Coatings Handbook Edited by

Biomaterials and Regenerative Medicine in Ophthalmology

Sam Zhang

Edited by

Nanyang Technological University, Singapore Series: Advances in Materials Science and Engineering

T. V. Chirila

Biological and biomedical coatings have been studied extensively and are currently receiving much attention from nanotechnology researchers. Providing a timely reference for experts and newcomers, this comprehensive handbook explores the latest developments in films and coatings for biological and biomedical applications. The text covers a wide array of material types, including sol-gel, bioceramics, polymers, glass, nanomaterials, and chitosan. It also addresses various processes for developing and implementing these coatings, including CVD and PVD, drug delivery, released-control coatings, and spectroscopy.

Biomaterials have contributed in recent years to numerous medical devices for the restoration of eyesight. This book provides readers with a definitive coverage of biomaterials and techniques used for the repair and regeneration of the eye. Initial chapters review applications in the anterior segment of the eye. A second group of chapters discuss applications in the posterior segment of the eye. The final group of chapters in the book covers other pertinent topics such as hydrogel sealants for wound repair in ophthalmic surgery, orbital enucleation implants, and polymeric materials for orbital reconstruction.

Catalog no. K11126, ISBN: 978-1-4398-2125-1 April 2011, 7 x 10, 936 pp. Suggested Price: $249.95 / £159.00

Catalog no. N10052, ISBN: 978-1-4398-0215-1 January 2010, 6 x 9, 560 pp. Suggested Price: $244.99 / £155.00

Two-Volume Set

Biomaterials & Medical Devices

Available in eBook

Biological and Biomedical Coatings Handbook Applications

Biomaterials and Tissue Engineering in Urology Edited by

Catalog no. K12270, ISBN: 978-1-4398-4996-5 April 2011, 7 x 10, 520 pp. Suggested Price: $139.95 / £89.00

John Denstedt

Available in eBook

Wake Forest University, Winston-Salem, North Carolina, USA

Biological and Biomedical Coatings Handbook Processing and Characterization

Queensland Eye Institute, Australia

Catalog no. K12269, ISBN: 978-1-4398-4995-8 April 2011, 7 x 10, 416 pp. Suggested Price: $139.95 / £89.00

University of Western Ontario, Canada

Anthony Atala An invaluable resource for clinicians and researchers in materials and biomedical devices, this text summarizes recent research on the use of biomaterials and tissue engineering in the treatment of urological disorders. Part one reviews the fundamentals including biofilms and encrustation formation. Part two then discusses recent advances in biomaterials and the design of urological devices such as metal ureteral stents, self-lubricating catheter materials, and penile implants. The final section addresses urological tissue engineering, covering artificial and natural biomaterials, nanotechnology, and placental stem cells used for the regeneration of urological tissue and organs. Catalog no. N10041, ISBN: 978-1-4398-0177-2 June 2009, 6 x 9, 500 pp. Suggested Price: $247.95 / £150.00

Available in eBook

Biologically Inspired Textiles Edited by

A. Abbott Clemson University, South Carolina, USA

Biomaterials for Treating Skin Loss Denis Orgill

M. Ellison

Brigham and Women’s Hospital, Boston, Massachusetts, USA

Clemson University, South Carolina, USA Eastman Dental Institute, UK

Carlos Blanco University Hospital Maastricht, The Netherlands

Written by a distinguished team of international authors, Biologically Inspired Textiles explores the current state of the art in this research arena and examines how biomimetics are increasingly applied to new textile technologies. It discusses the principles, production, and properties of biomimetics. Chapters include recombinant DNA technologies and their application for protein production, spinning of fibres from protein solutions and structure/function relationships in spider silk. Building on this foundation, the book then provides a review of the application of biomimetics to a range of textile applications, including the design of clothing and self-cleaning textiles.

A comprehensive review of the range of biomaterials for treating skin loss, this book begins with an examination of the basics of skin replacement with chapters on markets and regulation, biomechanics, and the biological environment of skin. It then reviews epidermal and dermal replacement technology with discussions on alternative delivery of keratinocytes, collagen-based and human origin-based dermal replacement, and lyophilized xenogenic products. The book closes with an exploration of combined dermis and epidermal replacement technologies and provides a round-up of skin replacement principles.

Catalog no. WP7985, ISBN: 978-1-4200-7985-2 March 2009, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $219.95 / £115.00

Catalog no. N10002, ISBN: 978-1-4200-9989-8 February 2009, 6 x 9, 320 pp. Suggested Price: $239.95 / £125.00

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The ISO 13485 Standard

Edited by

A Complete Guide to Quality Control

L. Ambrosio

Itay Abuhav

University of Naples Federico II, Italy

Hinterforst, Switzerland

Biocomposites are widely used in the medical industry to repair bone, cartilage, ligaments, and tendons. This book provides a thorough review of the current situation, recent progress, and future trends in composites for biomedical applications. It concentrates on the research and applications of this increasingly popular family of materials. The book begins with an introduction to the material, focusing on the properties, fabrication, and design of composites. It then discusses particular applications and biocompatibility of biocomposites. The final group of chapters analyses the mechanical behavior and failure of biocomposites and their future potential.

The United States and European Union now require the ISO 13485 Standard certification for medical device manufacturers. Written by an experienced industry professional, this practical book provides a complete guide to the ISO 13485 Standard certification for medical device manufacturing in terms of quality control. It covers all the requirements of ISO 13485 and offers a stepby-step comparison between the ISO 13485 and ISO 9001, enabling a sound understanding of these new procedures.

Catalog no. N10042, ISBN: 978-1-4398-0178-9 December 2009, 6 x 9, 648 pp. Suggested Price: $249.95 / £160.00

Catalog no. K12946, ISBN: 978-1-4398-6611-5 June 2011, 6 x 9, 300 pp. Suggested Price: $129.95 / £82.00 Available in eBook

Bone Repair Biomaterials Edited by

Joseph A. Planell and Damien Lacroix Universitat Politecnica de Catalunya, Spain

Textbook

Cambridge University, UK

A Laboratory Course in Biomaterials

Antonio Merolli

Wujing Xian

Universita Cattolica del Sacro Cuore, Italy

University of Illinois at Urbana-Champaign, USA

A fundamental aspect of the rapidly expanding medical care sector, bone repair continues to benefit from emerging technological developments. This text provides researchers and students with a comprehensive review of the materials science and engineering principles behind these developments. The first part reviews the fundamentals of bone repair and regeneration. Further chapters discuss the science and properties of biomaterials used in bone repair, including metals and biocomposites. Final chapters analyze device considerations such as implant lifetime and failure, and discuss potential applications, as well as the ethical issues that continually confront researchers and clinicians.

A new teaching tool for instructors in biomaterials and bioengineering, this volume is a comprehensive laboratory textbook. It trains students in laboratory skills, data analysis, problem solving, and scientific writing and integrates a variety of principles that include materials science, chemistry, biochemistry, molecular and cell biology, and engineering. Providing detailed descriptions, explanations, and illustrations of experiments, the text also includes a series of questions and answers at the end of each chapter to clarify concepts. Many of the experiments presented are adapted from research papers to reflect the recent progress in biomaterials and bioengineering.

Catalog no. N10044, ISBN: 978-1-4398-0195-6 September 2009, 6 x 9, 496 pp. Suggested Price: $229.95 / £145.00

Catalog no. 75829, ISBN: 978-1-4200-7582-3 June 2009, 7 x 10, 216 pp., Soft Cover Suggested Price: $61.95 / £39.99

Serena M. Best

Macroporous Polymers Production Properties and Biotechnological/ Biomedical Applications

Cellular Response to Biomaterials

Edited by

Bo Mattiasson and Igor Galeaev

Edited by

Lund University, Sweden

Lucy Di Silvio

Ashok Kumar

Kings College London, UK

Indian Institute of Technology, Kampur, India

This volume discusses the response of cells to a wide range of biomaterials targeted at specific medical applications. It first examines cell responses to a variety of polymers and ceramics and discusses degradable polymers and biocompatibility. The next section examines cell responses and regenerative medicine with topics such as vascular grafts, nerve repair, and Bioglass®. Lastly, the text explores the effect of surfaces and proteins on cell response. Specific chapters review nanoengineered surfaces, the influence of plasma proteins on bone cell adhesion, and surface modification of titanium implants.

Macroporous polymers are rapidly becoming the material of choice for many tissue engineering, bioseparation, and bioprocessing applications. Presented in a systematic way, this book addresses the production, characterization, and application of these polymers. The text considers traditional methods of production, including phase separation polymerization, leaching, foaming, and double emulsion, as well as newly merging methods such as cryogelation. The chapters also detail the various applications of macroporous gels for the separation of biomolecules and for the cultivation of mammalian cells in bioreactors, as well as for tissue engineering.

Catalog no. WP9373, ISBN: 978-1-4200-9373-5 January 2009, 6-1/8 x 9-1/4, 500 pp. Suggested Price: $289.95 / £153.00

Catalog no. 84615, ISBN: 978-1-4200-8461-0 December 2009, 6-1/8 x 9-1/4, 525 pp. Suggested Price: $133.95 / £85.00 Available in eBook

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Biomaterials & Medical Devices

Biomedical Composites

Materials Science for Dentistry Ninth Edition

Edited by

B. W. Darvell

Biomaterials & Medical Devices 40

Metals for Biomedical Devices Mitsuo Niinomi

The University of Hong Kong

Tohoku University, Japan

Materials Science for Dentistry provides a fundamental understanding of the materials on which dentistry depends, covering those aspects of structure and chemistry which govern the behavior and performance of the materials in use. It discusses gypsum, polymers, acrylic, cements, waxes, porcelain, and metals. Other chapters review topics such as surfaces, corrosion, mixing, casting, cutting, and bonding as well as mechanical testing. The new edition includes a new chapter on further aspects of mechanical testing and new material on condensation silicone and phosphate-bonded investment chemistries, mixing, MTA™ and alternative radiographic imaging techniques.

Given their widespread use in medical devices, it is vital that the fundamentals and behavior of metals are understood. In meeting such a need, this volume reviews the latest techniques in metal processing methods and the critical aspects of their behavior that might effect production and application. The text reviews the current status and selection of metals for biomedical devices before moving on to cover mechanical behavior, degradation, and testing. A final section discusses cardiovascular and orthopaedic uses and the employment of new generation biomaterials.

Catalog no. N10006, ISBN: 978-1-4398-0105-5 June 2009, 6 x 9, 662 pp., Soft Cover Suggested Price: $69.95 / £46.99

Materials Science of DNA

Catalog no. N10188, ISBN: 978-1-4398-3107-6 May 2010, 6 x 9, 432 pp. Suggested Price: $229.95 / £145.00

Korea University, Seoul

Physical Enhancement Strategies for Topical and Transdermal Drug Delivery

James Grote

Ajay K Banga

AFRL/RXPS, Wright Patterson Air Force Base, Ohio, USA

Mercer University, Atlanta, Georgia, USA

As interest continues to grow, DNA is expected to occupy the central position in nanobiotechnology because of its structural and chemical characteristics. With chapters written by experts in their respective fields, this text is the first to address the materials science facet of DNA, rather than its chemical, biochemical, or biological aspects and chiefly focuses on the rapidly growing fields of nanoscience, nanotechnology, and biotechnology. It includes tables, graphs, equations, and an ancillary CD-ROM to provide understanding of DNA and the high potential of this biopolymer as advanced material.

Interest in drug delivery systems is growing for the increased number of biologic medicines, which include peptides, proteins, and nucleic acids. Transdermal delivery is an important part of such systems, and the use of physical enhancement methods to penetrate the skin barrier is where the field is headed. This book reviews the strategies available for the delivery of compounds into and through the skin. It also focuses on technological developments in the domain of nanotechnology that can be exploited to enhance the transdermal delivery of drugs.

Edited by

Jung-II Jin

Catalog no. K11352, ISBN: 978-1-4398-2741-3 June 2011, 6-1/8 x 9-1/4, 344 pp. Suggested Price: $119.95 / £76.99

Catalog no. K10285, ISBN: 978-1-4398-0509-1 June 2011, 6-1/8 x 9-1/4, 368 pp. Suggested Price: $129.95 / £82.00 Available in eBook

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Medical and Healthcare Textiles 2007 Proceedings of the Fourth International Conference on Healthcare and Medical Textiles Edited by

Polymeric Biomaterials Revised and Expanded Edited by

J.F. Kennedy

Severian Dumitriu

Chembiotech Ltd., UK

S.C. Anand, M. Miraftab, and S. Rajendran

University of Sherbrooke, Canada

University of Bolton, UK

Offering nearly 7,000 references-3,900 more than the first edition-Polymeric Biomaterials is an up-to-the-minute source for plastics and biomedical engineers, polymer scientists, biochemists, molecular biologists, macromolecular chemists, pharmacists, cardiovascular and plastic surgeons, and graduate and medical students in these disciplines. Completely revised and updated, it includes coverage of genetic engineering, synthesis of biodegradable polymers, hydrogels, and mucoadhesive polymers, as well as polymers for dermacosmetic treatments, burn and wound dressings, orthopedic surgery, artificial joints, vascular prostheses, and in blood contacting systems.

This volume is based on of papers presented in 2007 at the University of Bolton. Contributors cover a range of topics. These include emerging textilebased biomaterials, hygienic textiles, the use of textiles in infection control and as barrier materials, bandaging and pressure garments for managing chronic infections such as ulcers, the role of textiles in the management of burns and wounds, textile-based implantable devices such as tissue scaffolds and sutures, and intelligent textiles. Catalog no. WP7989, ISBN: 978-1-4200-7989-0 August 2010, 6-1/8 x 9-1/4, 512 pp. Suggested Price: $249.95 / £159.00

Catalog no. DK1811, ISBN: 978-0-8247-0569-5 November 2001, 287x208, 1168 pp. Suggested Price: $309.95 / £179.00 Available in eBook

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Shape Memory Alloys for Biomedical Applications

Polyolefin Fibres

Edited by

Samuel C. O. Ugbolue

Takayuki Yoneyama Nihon University, Chiyoda-ku, Tokyo

The Hong Kong Polytechnic University and The University of Massachusetts, USA

Shuichi Mayazaki

Polyolefins, such as polyethylene and polypropylene, are among the most widely used commercial polymers. These versatile fibers are durable, chemically resistant, lightweight, economical, and functional. This work provides researchers a comprehensive resource that will assist them with material improvement and product development. The first chapters discuss the structural and chemical properties of different types of polyolefins, as well as production methods. Middle chapters delve into functionality improvement. Closing chapters address how polyolefins can be incorporated into specific industrial, medical, and automotive products.

Shape memory metals are suitable for a wide range of biomedical devices, including applications in dentistry, bone repair, urology, and cardiology. This book provides a thorough review of shape memory metals and devices for medical applications. The first part of the book discusses the materials, primarily Ti-Ni based alloys. It covers mechanical properties, thermodynamics, and composition as well as fabrication of parts, chemical reactivity, surface modification, and biocompatibility. The contributors also examine stents, orthodontic devices, and endodontic instruments. Finally, future developments in this area are discussed including alternatives to Ti-Ni based shape memory alloys.

Catalog no. N10000, ISBN: 978-1-4200-9985-0 February 2009, 6 x 9, 320 pp. Suggested Price: $239.95 / £125.00

Catalog no. WP7966, ISBN: 978-1-4200-7966-1 March 2009, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $219.95 / £126.00

Polyurethane Shape-Memory Polymers

Titanium

W. M. Huang

University of Tsukuba, Japan

Modelling Microstructure, Properties and Applications

Nanyang Techological University, Singapore

Edited by

Yang Bin

Wei Sha

Helvoet Rubber & Plastic Technologies Pte Ltd.

Yong Qing Fu

University of Canterbury, New Zealand, and The Queen’s University Belfast, UK

Biomaterials & Medical Devices

Industrial and Medical Applications

Savko Malinov

Heriot Watt University, Edinburgh, UK

Shape memory polymers have attracted serious attention as a result of their ability to recover their original shape after having a stimulus applied to them. From their history to the most recent developments, this book provides the full story of polyurethane-based shape memory polymers, including discussion of thermomechanical properties and behavior of the polymer and its composites. Next, it addresses the modification of the shape memory polymer and introduces novel actuation mechanisms. Finally, the author presents a spectrum of state-ofthe-art and potential applications of this material and its composites. Catalog no. K11723, ISBN: 978-1-4398-3800-6 May 2011, 6-1/8 x 9-1/4, 296 pp. Suggested Price: $129.95 / £82.00

The Queen’s University of Belfast, UK

An exploration of modeling techniques for the microstructure and properties of titanium and its alloys, this book discusses experimental techniques such as microscopy, synchrotron radiation X-ray diffraction, and differential scanning calorimetry. It reviews physical modelling methods including thermodynamic modelling, the Johnson-Mehl-Avrami method, finite element modelling, the Phase-field method, the cellular automata method, crystallographic and fracture behaviour of titanium aluminide, and atomistic simulations of interfaces and dislocations relevant to TiAl. The coverage includes neural network models and surface engineering products.

Available in eBook

Catalog no. N10034, ISBN: 978-1-4398-0148-2 June 2009, 6 x 9, 500 pp. Suggested Price: $255.95 / £155.00

Regenerative Medicine and Biomaterials for the Repair of Connective Tissues

Usability Testing of Medical Devices

Edited by

Michael Wiklund, Jonathan Kendler, and Allison Yale Strochlic

Charles Archer and Jim Ralphs Cardiff University, UK

Wiklund Research Design, Concord, Massachusetts, USA

Regenerative medicine for the repair of connective tissues is a fast moving field which generates a lot of interest. The biomaterials and biomechanics for soft tissue repair have been under-represented in the past, particularly the natural connection between cartilage, tendons, and ligaments is often not made. This book addresses the gap by exploring the natural association of cartilage, tendons, and ligaments to provide a review of the different structures, biomechanics and, more importantly, provide a discussion of practical techniques and biomaterials which are being used to repair connective tissues.

Informative, practical, and engaging, this handbook covers how to conduct usability tests of medical devices. Recognizing that the intended readers are busy and disinclined to read lengthy textbooks, this book has been carefully designed to be concise and visual, allowing readers to jump from one section to another as needed. The book provides a general understanding of usability testing and reviews key concepts. It highlights the challenges of validating that protect against dangerous errors that could lead to patient injury and death.

Catalog no. N10011, ISBN: 978-1-4398-0110-9 February 2010, 6 x 9, 600 pp. Suggested Price: $249.95 / £159.00

Catalog no. K10595, ISBN: 978-1-4398-1183-2 December 2010, 6-1/8 x 9-1/4, 410 pp. Suggested Price: $69.95 / £44.99 Available in eBook

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Quality and Safety in Radiotherapy

Biomaterials & Medical Devices / Biomedical Engineering 42

Todd Pawlicki and Arno J. Mundt

Basic Introduction to Bioelectromagnetics

University of California San Diego, La Jolla, USA

Second Edition

Edited by

Peter B. Dunscombe Tom Baker Cancer Center, Calgary, Alberta, Canada

Pierre Scalliet

Cynthia Furse, Douglas A. Christensen, and Carl H. Durney University of Utah, Salt Lake City, USA

St. Luc University Hospital, Belgium

The first text to focus solely on quality and safety in radiotherapy, this work encompasses not only traditional technically oriented quality assurance activities, but also general approaches regarding quality and safety. It includes contributions from experts inside and outside the field to discuss the processes and the people delivering the service. It includes discussions about lean thinking, looks at reactive and prospective error management techniques, deals broadly with techniques to monitor, assure, and improve quality, and provides explicit details of quality control relating to equipment and patient-specific issues.

Completely revised and updated, this new edition facilitates the process of interdisciplinary research by introducing life scientists to the basic concepts of electromagnetic fields. The book outlines elements of EM that are helpful to life scientists working with physicists and electrical engineers. Each concept is presented with an associated application and discussion. Example applications include MRI, NMR, ultrasound, hyperthermia, neural stimulation, and cardiac pacing/defibrillation. With the liberal use of diagrams and graphs, this text covers the entire frequency spectrum through optical frequencies from a qualitative perspective beneficial to life scientists.

Catalog no. K10241, ISBN: 978-1-4398-0436-0 December 2010, 8-1/2 x 11, 643 pp. Suggested Price: $129.95 / £82.00

Catalog no. 55429, ISBN: 978-1-4200-5542-9 March 2009, 7 x 10, 288 pp. Suggested Price: $102.95 / £65.99

Available in eBook

Quality Control Training Manual Comprehensive Training Guide for API, Finished Pharmaceutical and Biotechnologies Laboratories

Textbook

Basic Transport Phenomena in Biomedical Engineering Second Edition

Syed Imtiaz Haider and Erfan Asif Syed

Ronald L. Fournier

Julphar Gulf Pharm Industries, United Arab Emirates

University of Toledo, Ohio, USA

A valuable tool for chemists and analysts working in Quality Control laboratories, this book provides technical solutions that fulfill training requirements and build skilled manpower. The text is written for practitioners in quality control laboratories, product development laboratories, and stability laboratories in pharmaceutical and bio-pharmaceutical manufacturing, along with students in pharmaceutical and biotechnology development. It includes chapters on various elements commonly used in quality control labs, with questions at the end to ensure understanding. It also includes training manuals, a training log, and a CD-ROM on various laboratory aspects.

This text combines the basic principles and theories of transport in biological systems with fundamental bioengineering. It contains real-world applications in drug delivery systems, tissue engineering, and artificial organs. Considerable significance is placed on developing a quantitative understanding of the underlying physical, chemical, and biological phenomena. Therefore, many mathematical methods are developed using compartmental approaches. The book is replete with examples and problems.

Catalog no. K12268, ISBN: 978-1-4398-4994-1 January 2011, 6 x 9, 479 pp. Suggested Price: $139.95 / £89.00

Catalog no. GS1058, ISBN: 978-1-59169-026-9 July 2006, 6 x 9, 472 pp., Soft Cover Suggested Price: $135.95 / £87.00

Textbook

Biofluid Mechanics Advanced Electroporation Techniques in Biology and Medicine Andrei G. Pakhomov, Damijan Miklavcic, and Marko S. Markov

The Human Circulation Krishnan B. Chandran University of Iowa, Iowa City, USA

Alit P. Yoganathan Georgia Tech, USA

Stanley E. Rittgers University of Akron, Ohio, USA

During the last several decades, intense study has taken place on the effects of electromagnetic fields on living tissues. Reflecting this inquiry, this book discusses the theoretical and experimental evidence of these electromagnetic fields and electric pulses and examines their importance in medicine and biology. The authors present the basic techniques applied in electroporation and the advanced methods for creation of nanopores, highlighting their basic science and clinical applications. Topics include nano electroporation, classic electroporaiton, experimental evidence for electroporation of living cells, and electroporation for cancer and wound healing.

Based on the authors’ courses on cardiovascular fluid mechanics, this textbook is ideal for an introductory course on fluid mechanics in the human circulation. It covers fluid and solid mechanics as well as cardiovascular physiology; vascular implants and measurement techniques in the cardiovascular system; design and fluid mechanical evaluation of artificial heart valves; and fluid mechanical alterations related to vascular graft and stent implants. The book includes models illustrating fluid mechanics in the human circulation at the arterial level and detailed derivations of classic solutions and real-life applications.

Catalog no. K11005, ISBN: 978-1-4398-1906-7 June 2010, 7 x 10, 528 pp. Suggested Price: $139.95 / £89.00

Catalog no. 7328, ISBN: 978-0-8493-7328-2 November 2006, 6 x 9, 432 pp. Suggested Price: $109.95 / £69.99

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Biologically Inspired Robotics Edited by

Textbook

The Chinese University of Hong Kong

Second Edition

Dong Sun City University of Hong Kong, Kowloon

Arthur B. Ritter, Stanley Reisman and Bozena B. Michnaik

This cutting-edge reference is based on a selection of speeches from the 2009 IEEE International Conference on Robotics and Biomimetics. The 16 chapters, rewritten from the speeches to include extra detail and analysis, cover robotic design, micro/nano robots for bio-systems and biomedicine, and biological measurement and actuation. A section on cybernetics is included as well. Written for graduate students and researchers in control engineering and robotics, this text helps the reader understand research trends and future development of biorobotics and biologically inspired robot design. It includes a wealth of figures and hundreds of equations.

Integrating engineering, medicine, biology, and physics, this book clearly defines basic principles in image processing and biomechanics, modeling physiological processes, and bioelectric signal analysis to build a solid understanding of devices and designs for improved functioning of the human body. It includes cutting-edge discussions of tissue engineering, cardiovascular components, bone regrowth, and nerve regeneration. Other topics include technologies at the forefront of cardiac care, such as total artificial hearts, left ventricular assist devices, and stents, as well as issues related to minimally invasive and robotic surgery, next-generation imaging devices, and nanodevices.

Catalog no. K12555, ISBN: 978-1-4398-5488-4 June 2011 Suggested Price: $99.95 / £63.99

Catalog no. K10621, ISBN: 978-1-4398-1232-7 May 2011, 6-1/8 x 9-1/4, 448 pp. Suggested Price: $99.95 / £63.99

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Textbook

Biology for Engineers Arthur T. Johnson University of Maryland, College Park, USA

Biomedical Microsystems Ellis Meng University of Southern California, Los Angeles, USA

Biology is a critical application area for engineering analysis and design, and students in engineering programs must be well-versed in its fundamentals. This introductory text minimizes unnecessary memorization of connections and classifications and instead emphasizes concepts, technology, and the utilization of living things. Filled with practical examples, the book discusses biological responses from the perspectives of psychology, human factors, genetics, plant and animal physiology, imaging, control systems, actuary, and medicine; scaling of biological responses and attributes; and different types of applications related to biological systems. Numerous tables of useful information are included.

Written by an active researcher who was recently named one of Technology Review’s Young Innovators Under 35, this book begins with an introduction to the benefits of miniaturization. It then introduces materials, fabrication technology, and the necessary components of all bioMEMS. The author also covers fundamental principles and building blocks, including microfluidic concepts, lab-on-a-chip systems, and sensing and detection methods. The final chapters explore several important applications of bioMEMS, such as microdialysis, catheter-based sensors, MEMS implants, neural probes, and tissue engineering. Detailed examples, exercises, and illustrations help elucidate the concepts.

Catalog no. 77635, ISBN: 978-1-4200-7763-6 September 2010, 7 x 10, 775 pp. Suggested Price: $99.95 / £44.99

Catalog no. 51229, ISBN: 978-1-4200-5122-3 September 2010, 6-1/8 x 9-1/4, 408 pp. Suggested Price: $89.95 / £49.99

The Biomedical Engineering Handbook Third Edition - Three Volume Set Edited by

Biomedical Engineering

Biomedical Engineering Principles

Yunhui Liu

Biomedical Sensors and Instruments Second Edition Tatsuo Tagawa Waseda University, Tokorozawa, Saitama, Japan

Joseph D. Bronzino

Toshiyo Tamura

Trinity College, Hartford, Connecticut, USA Series: Electrical Engineering Handbook

P. Ake Oberg

Chiba University, Japan Linkoping University Hospital, Sweden

Already referred to as the “bible” of biomedical engineering, the third edition of The Biomedical Engineering Handbook is even vaster in its scope and depth than the previous two editions. Individually, each volume provides a convenient, sharply focused guide to specialized information. Together, these three volumes form the most comprehensive, authoritative, and interdisciplinary reference available, conveniently organized for quick access. This edition includes new sections on neuroengineering, infrared imaging, bioinformatics, molecular biology, and bionanotechnology.

Written for graduate-level engineering and kinesiology students, but also beneficial professionals, this book is an engineering-oriented reference on upper-extremity musculoskeletal disorders. It begins with an introduction to the human musculoskeletal system, neuromuscular physiology, and the motor control system and is followed by the mechanics and models of the components of the neuromuscular system. The book then goes on to present instruments and tools to identify the work-related musculoskeletal disorders (WRMSDs) in the industrial workplace. Final chapters provide specific applications to hand tools and computer workstations, the culprits for most upper limb ailments.

Catalog no. 2124, ISBN: 978-0-8493-2124-5 April 2006, 7 x 10, 4232 pp. Suggested Price: $267.95 / £171.00

Catalog no. 9078X, ISBN: 978-1-4200-9078-9 March 2011, 7 x 10, 428 pp. Suggested Price: $139.95 / £89.00

Available in eBook

Available in eBook For more information and a complete list of titles, visit us at www.crcpress.com

Biomedical Technology and Devices Handbook

Bionanotechnology II

Edited by

James Moore and George Zouridakis

David E. Reisner

Biomedical Engineering

Handbook Series for Mechanical Engineering

The Nano Group, Inc., Farmington, Connecticut, USA

Concise yet comprehensive, the Biomedical Technology and Devices Handbook illuminates the equipment, devices, and techniques used in modern medicine to diagnose, treat, and monitor human illnesses. With topics ranging from the basic procedures like blood pressure measurement to cutting-edge imaging equipment, biological tests, and genetic engineering, the book is organized to navigate smoothly from simple procedures and concepts to the more sophisticated and complex ones. Each section contains a description of the technique, its technical considerations, and its use according to its applications and relevant body systems.

A blend of information from the Biomedical Engineering Handbook and new material, this book draws on the experience of experts from countries such as Iran, Cuba, South Africa, UK, Canada, China, India, and Russia. It reflects the increasing emphasis and importance of nanomedicine and biotechnology with the inclusion of topics such as Biomimicry, Stem Cells, Optical Togs, Nanocoating for Medical Implantable Devices, Food Industry, Cosmetics, Cardiac Diagnosis, Batteries, Drug Delivery, Photonics, DNA Building Blocks, Protein Devices, Quantum Dots, Bioanalysis, Optics, Nanomedicine, Personalized Medicine, and the Business of Emerging Bionanotech Companies.

Catalog no. 1140, ISBN: 978-0-8493-1140-6 August 2003, 7 x 10, 840 pp. Suggested Price: $226.95 / £145.00

Catalog no. K10254, ISBN: 978-1-4398-0463-6 January 2011, 7 x 10, 350 pp. Suggested Price: $99.95 / £63.99

Available in eBook

Biologically Inspired Technologies

Clinical Procedures for Medical Technology Specialists

Yoseph Bar-Cohen

Laurence J. Street

Jet Propulsion Laboratory, Pasadena, California, USA

Chilliwack General Hospital, Rosedale, British Columbia, Canada

Introducing the principles of using biology to inspire designs as well as biological mechanisms as models for technology, this book surveys the field of biomimetics, from modeling to applications. Biomimetics: Biologically Inspired Technologies discusses the biological models useful to engineering, the current state of the field, and the progress and challenges awaiting future researchers. Taking a systems approach to design, it reflects the interdisciplinary nature of the science, integrating materials, structures, actuators, sensors, interfaces, control, adaptability, and intelligence, among others.

This comprehensive book provides an overview of the most common medical procedures performed in modern clinical settings. Each section presents common names for the procedure; an outline of the disease or injury for which the procedure is performed; a brief review of the anatomical structures and physiological processes that are involved; staffing, equipment, and pre-procedure requirements; a detailed description of the procedure itself; and a discussion of expected outcomes as well as potential complications. Each chapter includes a summary and study questions, while the appendices offer a glossary and a table of normal values.

Biomimetics

Global Prospects

Catalog no. 3163, ISBN: 978-0-8493-3163-3 November 2005, 7 x 10, 552 pp. Suggested Price: $179.95 / £114.00 Available in eBook

Catalog no. 81993, ISBN: 978-1-4200-8199-2 October 2010, 7 x 10, 344 pp. Suggested Price: $69.95 / £44.99 Available in eBook

Computational Hydrodynamics of Capsules and Biological Cells

Bionanotechnology

Edited by

Maheshwar Sharon IIT Bombay (retired), Birla College, Nanotechnology Research Center

Madhuri Sharon Monad Nanotech Pvt. Limited, Mumbai, India

This book focuses on all fundamental bionanomachines including their applications towards the service of humankind. These bionanomachines would include such topics as DNA, RNA, proteins, carbohydrates, and lipids, which are vastly pervasive in all biosystems existing in this world. This book is a distillation of the author’s research and experimentation gathered while doing groundbreaking research in the field of bionanotechnology. It represents well documented and researched information about how nanoscale technologies may enhance our lives and health resulting in significantly changing the world we live in. Catalog no. K12393, ISBN: 978-1-4398-5214-9 January 2011, 6 x 9, 300 pp. Suggested Price: $79.95 / £49.99

C. Pozrikidis University of Massachusetts, Amherst, USA Series: Chapman & Hall/CRC Mathematical & Computational Biology

A roadmap to the current state of the art in computational cellular mechanics and biofluiddynamics, this volume provides a comprehensive and rigorous introduction to the fundamental concepts, mathematical formulation, alternative approaches, and predictions of this evolving field. It covers advanced numerical methods for simulating the motion of rigid particles (platelets) and the flow-induced deformation of liquid capsules and cells enclosed by viscoelastic membranes. The book also enables readers to compare solutions produced by different numerical approaches and assess the efficiency of alternative formulations. MATLAB® code and other data are available on the book’s website. Catalog no. K11057, ISBN: 978-1-4398-2005-6 June 2010, 6-1/8 x 9-1/4, 327 pp. Suggested Price: $129.95 / £82.00 Available in eBook

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George Zouridakis

Ergonomics for Rehabilitation Professionals

University of Houston, Texas, USA

Edited by

Andrew C. Papanicolaou

Shrawan Kumar

University of Texas - Houston, USA

University of North Texas, Fort Worth, USA

The use of electrophysiological recordings to assess the functional integrity of the nervous system during surgery is gradually becoming part of standard medical practice. This book provides a general but comprehensive introduction to intraoperative monitoring. It includes pictures and drawings that show the exact placement of stimulation and recording electrodes, and contains tables that show exact stimulation and recording parameters and the detailed effects of anesthetic agents on neurophysiological signals. It offers examples of normal recordings and presents discussion of problems that can occur during surgery along with the corresponding abnormal recordings.

Designed to meet the diverse needs of therapists, this book presents a new approach to rehabilitation that integrates ergonomics concepts to address the wide range of problems commonly encountered by professionals. It addresses general concepts such as anthropometry and tissue mechanics then examines whole body biomechanics, demonstrating the ergonomic effects of physiological and biomechanical factors. The author also focuses on regional biomechanics, explaining the rationale for ergonomic intervention, and discusses the ergonomic paradigm in rehabilitation, including the use of physical demands analysis.

Catalog no. 0886, ISBN: 978-0-8493-0886-4 December 2000, 6-1/8 x 9-1/4, 216 pp. Suggested Price: $124.95 / £79.99 Available in eBook

Catalog no. 8146, ISBN: 978-0-8493-8146-1 April 2009, 6-1/8 x 9-1/4, 640 pp. Suggested Price: $102.95 / £65.99 Available in eBook

Handbook of Anatomical Models for Radiation Dosimetry

Design Controls for the Medical Device Industry

Edited by

Marie B. Teixeira

Keith F. Eckerman

QA/RA Compliance Connection, Inc., Odessa, Florida, USA

Richard Bradley Global Consulting Network, Inc., Palm Harbor, Florida, USA

Design Controls for the Medical Device Industry provides real-world examples, strategies, and templates for the implementation of effective design control programs that meet ISO 9000 and FDA QSR standards and regulations. It also offers product development models for the production of safe, durable, and cost-efficient medical devices and systems. The book details procedures utilized by leading companies to successfully meet FDA and end-user requirements, manufacture high-quality products, and improve and generate profit. It presents blueprints for the application, evaluation, and refinement of quality assurance and performance practices, from product launch through engineering and assembly. Catalog no. DK5666, ISBN: 978-0-8247-0830-6 September 2002, 6 x 9, 254 pp. Suggested Price: $189.95 / £121.00 Available in eBook

Textbook

Design of Biomedical Devices and Systems Second edition

Xie George Xu Rensselaer Polytechnic Institute, Troy, New York, USA Oak Ridge National Laboratory, Tennessee, USA Series in Medical Physics and Biomedical Engineering

This pioneering work brings together recommendations sanctioned by the International Commission on Radiological Protection (ICRP) and documents 40 years of cutting-edge work with Monte Carlo Codes and radiation protection dosimetry. Assembling the work of nearly all major phantom (computational model) developers around the world, it examines detailed accounts for each well-known phantom, including those for applications for radiation protection dosimetry involving environmental, nuclear power plant, and internal contamination exposures, as well as a host of medical applications. Related datasets can be downloaded from the authors’ website. Catalog no. C5979, ISBN: 978-1-4200-5979-3 September 2009, 7 x 10, 757 pp. Suggested Price: $133.95 / £85.00 Available in eBook

Handbook of Biological Effects of Electromagnetic Fields Third Edition - Two Volume Set Edited by

Frank S. Barnes

Paul H. King Vanderbilt University, Nashville, Tennessee, USA

Richard C. Fries Baxter Healthcare, Round Lake, Illinois, USA

The second edition of a bestseller, this book provides a comprehensive overview of biomedical device and system design — including topics related to databases, process analysis, and device improvement — from a strong design perspective. It covers all aspects of design that must be considered for complex biomedical projects. This second edition features information on device definition and reliability, as well as testing and hardware verification and each chapter has been updated to reflect the latest advances in the field. Catalog no. 61798, ISBN: 978-1-4200-6179-6 August 2008, 7 x 10, 424 pp. Suggested Price: $124.95 / £79.99

Biomedical Engineering

A Concise Guide to Intraoperative Monitoring

University of Colorado, Boulder, USA

Ben Greenebaum University of Wisconsin, Kenosha, USA Series: Handbook of Biological Effects of Electromagnetic Fields, 3Ed

Entering its third edition, the bestselling Handbook of Biological Effects of Electromagnetic Fields is a definitive reference for researching bioeffects of static, low-, and high-frequency fields. It incorporates extensive new material and up-to-date data, results, and discussions into two cohesive volumes. The first installment focuses on physics, engineering, and chemical aspects of electromagnetic fields, including molecular-level mechanisms, while the second concentrates on biological and medical aspects, including physiological effects, medical applications, and exposure standards. The handbook examines the latest applications of EM fields, particularly for medical treatment and diagnostics. Catalog no. 2952, ISBN: 978-0-8493-2952-4 November 2006, 7 x 10, 960 pp. Suggested Price: $162.95 / £99.00

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Handbook of Biomedical Optics Edited by

David A. Boas Harvard Medical School, Charlestown, Massachusetts, USA University of Cyprus, Nicosia

Introduction to Complexity and Complex Systems

Nimmi Ramanujam

Robert B. Northrop

Constantinos Pitris

Biomedical Engineering

Duke University, Durham, North Carolina, USA

University of Connecticut, Storrs, USA

Taking a broad yet detailed approach, this comprehensive handbook covers light-based diagnostic methodologies and light-mediated therapeutics as well as concepts and cutting-edge optical methods used in research and practice. Extensively illustrated, the book presents the theory and fundamentals, along with state-of-the-art applications. The expert contributors also discuss advantages and disadvantages of various techniques. After introducing the background principles of optics, light sources, and irradiation and basic tissue optics concepts, the book focuses on spectroscopic methods, tomographic imaging, microscopic imaging methods, molecular probe development, and phototherapy.

Written for students and professionals in the fields of biomedical engineering, systems biology, biophysics, and physiology, this unique reference covers complex issues within living systems. Topics explored include human responses to coping with complex systems, the Law of Unintended Consequences, the relation of complexity to evolution, the complexity inherent in invertebrate immune systems, and the complexity inherent in economic systems. A comprehensive glossary is included to help readers with acronyms and terms relating to complex, nonlinear biological systems. Also included are dynamic models and homework questions to further aid in understanding.

Catalog no. 90364, ISBN: 978-1-4200-9036-9 June 2011, 8-1/2 x 11, 848 pp. Suggested Price: $149.95 / £95.00

Catalog no. K11775, ISBN: 978-1-4398-3901-0 December 2010, 6 x 9, 551 pp. Suggested Price: $79.95 / £44.99

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Textbook

Handbook of Photonics for Biomedical Science Edited by

Introduction to Engineering Mechanics A Continuum Approach Jenn Stroud Rossmann

Valery V. Tuchin Saratov State University, Russia Series in Medical Physics and Biomedical Engineering

Textbook

Addressing the latest problems in biomedical optics and biophotonics, this handbook describes advanced biophotonics methods and techniques intensively developed in recent years. It discusses optical and terahertz spectroscopy and imaging methods for biomedical diagnostics based on the interaction of coherent, polarized, and acoustically modulated radiation with tissues and cells. It covers modalities of nonlinear spectroscopic microscopies, photonic technologies for therapy and surgery, and nanoparticle photonic technologies for cancer treatment and UV radiation protection. The text also elucidates the advanced spectroscopy and imaging of normal and pathological tissues. Catalog no. K10313, ISBN: 978-1-4398-0628-9 May 2010, 7 x 10, 868 pp. Suggested Price: $149.95 / £95.00 Available in eBook

Lafayette College, Easton, Pennsylvania, USA

Clive L. Dym Harvey Mudd College, Claremont, California, USA

The essence of continuum mechanics — the internal response of materials to external loading — is often obscured by the complex mathematics of its formulation. By building gradually from one-dimensional to two- and threedimensional formulations, this book provides an accessible introduction to the fundamentals of solid and fluid mechanics. This undergraduate text presents several real-world case studies, such as the St. Francis Dam, to illustrate the mathematical connections between solid and fluid mechanics, with an emphasis on practical applications of these concepts to mechanical, civil, and electrical engineering structures and design. Catalog no. 62719, ISBN: 978-1-4200-6271-7 November 2008, 6-1/8 x 9-1/4, 485 pp. Suggested Price: $94.95 / £53.99

Healthcare Sensor Networks Challenges Toward Practical Implementation Edited by

Victoria University, Melbourne, Australia

The Law of Regenerative Medicine and Tissue Engineering

Marimuthu Palaniswami

David S. Smith

University of Melbourne, Parkville, Victoria, Australia

Pepper Hamilton LLP, Pittsburgh, Pennsylvania, USA

From network deployment to secure monitoring, this book addresses the latest developments in healthcare sensor networks—human oriented networks of monitoring medical devices deployed on the body or in the surrounding infrastructure. The text discusses fundamental concepts and provides examples of clinical applications, including fall prevention for the elderly and monitoring children with cerebral palsy. Each chapter details a separate challenge in the design and implementation. The book addresses such challenges as higher data bandwidth demand, longer network operational time, robust network design in dynamic environments, and lower costs versus high computational demand.

Numerous clinical trials are currently in progress for complex tissue constructs and cell therapies. Many companies are commercializing skin substitutes, expanded cell populations for cartilage repair, and extracellular materials intended to enable remodeling or repair at the implementation site. This book provides an overview of legal and regulatory elements that can significantly impact the clinical introduction of cell- and tissue-based products. As a reference for important regulations at both the federal and state level, it guides the development of strategies for building patent portfolios and navigating FDA review for market approval.

Catalog no. K11159, ISBN: 978-1-4398-2181-7 May 2011, 6-1/8 x 9-1/4, 480 pp. Suggested Price: $149.95 / £95.00

Catalog no. K11293, ISBN: 978-1-4398-2650-8 May 2011, 6 x 9, 270 pp., Soft Cover Suggested Price: $59.95 / £38.99

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Daniel Tze Huri Lai and Rezaul Begg

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Edited by

Medical Nanotechnology and Nanomedicine

John G. Webster

Harry F. Tibbals

University of Wisconsin, Madison, USA Series: Electrical Engineering Handbook

University of Texas Southwestern Medical Center, Dallas, USA Series: Perspectives in Nanotechnology

Edited by one of the most renowned instrumentation experts in the world, this best-selling handbook contains nearly 150 contributions covering all aspects of the design and implementation of instrumentation. It describes the use of instruments and techniques for performing practical measurements in engineering, physics, chemistry, and the life sciences. Organized according to measurement problem, each section addresses the different ways of making a measurement for a given variable. Each chapter presents basic information, a detailed mathematical treatment, and advanced applications, evaluative opinions, and areas for future study.

This accessible guide reviews advances in nanoscience and nanotechnology and considers their applications in medicine. Providing an introduction to both the science and the infrastructure required to support these advances, this volume is written for non-experts, which can include medical researchers and clinicians, as well as those concerned with business aspects, regulation, and the administration of medical practices. The book provides a contextual background including history, definitions, and recent trends, and then investigates current and future nanotech applications in medicine and the biomedical sciences.

Catalog no. 8347, ISBN: 978-0-8493-8347-2 December 1998, 7 x 10, 2630 pp. Suggested Price: $226.95 / £145.00

Catalog no. K10431, ISBN: 978-1-4398-0874-0 September 2010, 6-1/8 x 9-1/4, 527 pp., Soft Cover Suggested Price: $69.95 / £44.99 Available in eBook

Paediatric Rehabilitation Engineering From Disability to Possibility

Mechanobiology Handbook

Edited by

Bloorview Kids Rehab, Toronto, Canada

Jiro Nagatomi Clemson University, South Carolina, USA

At appropriate levels, mechanical stimuli are necessary for growth and maintenance of healthy tissues and organs. Mechanobiology Handbook examines effects of mechanical force stimuli on cellular biological functions. The past two decades have seen a dramatic increase in the level of research in mechaniobiology. Collecting the cutting-edge research findings from a diverse range of scientists, this volume, which presents basic materials in mechanics and cell biology, is a reference for those new to the field and also is designed to stimulate new ways of thinking in current mechanobiology researchers. Catalog no. 91212, ISBN: 978-1-4200-9121-2 March 2011, 7 x 10, 560 pp. Suggested Price: $169.95 / £109.00 Available in eBook

Tom Chau Jillian Fairley CRC Press Series in Rehabilitation Science in Practice

Written by international experts, this book provides an up-to-date synopsis of advances in pediatric rehabilitation engineering research. Offering a single comprehensive resource on the latest research findings, each chapter presents a different area of technology or the developments of particular clinical relevance to pediatric rehabilitation. The material within each chapter also includes a conceptual description of the technology or underlying scientific principles, followed by a synthesis of relevant literature, recent research advances, selected clinical case studies (where applicable), and perspectives for future directions. Catalog no. K10416, ISBN: 978-1-4398-0842-9 December 2010, 6-1/8 x 9-1/4, 366 pp. Suggested Price: $139.95 / £89.00

Textbook

Physics for Diagnostic Radiology The Medical Device R&D Handbook

Third Edition

Edited by

Brian Heaton

Theodore R. Kucklick

Aberdeen Radiation Protection Services, UK Series in Medical Physics and Biomedical Engineering

TRKD Medical Devices, Los Gatos, California, USA

The Medical Device R&D Handbook is a practical, hands-on digest of medical device engineering that presents information that is often hard to find or gained by on-the-job experience. Highlights include using rapid-prototyping methods to develop medical devices and how to choose the best methods for certain applications, such as form, fit, and function, and meeting device regulatory requirements. It offers special techniques for iterating devices with the best possible results at the lowest cost. This book shortens the time it takes for engineers to become productive medical device designers. Catalog no. 2717, ISBN: 978-0-8493-2717-9 November 2005, 6-1/8 x 9-1/4, 376 pp. Suggested Price: $157.95 / £99.00 Available in eBook

Biomedical Engineering

The Measurement, Instrumentation and Sensors Handbook

Philip Palin Dendy Addenbrookes NHS Trust, Cambridge, UK

A complete course for radiologists studying for the FRCR part one exam and for graduate students in diagnostic radiology, the third edition of this popular text focuses on modern developments and new applications, including new imaging systems. The text follows the guidelines issued by the European Association of Radiology for training. Its analytical approach deals in a logical order with the wide range of imaging techniques available and explains how to use imaging equipment. The book includes the background physics necessary to understand the production of digitized images, nuclear medicine, and magnetic resonance imaging. Catalog no. 83155, ISBN: 978-1-4200-8315-6 June 2011, 7 x 10, 728 pp. Suggested Price: $79.95 / £49.99 Also Available in Soft Cover

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Biomedical Engineering 48

The Physiology of Bioelectricity in Development, Tissue Regeneration and Cancer

Reliable Design of Medical Devices

Edited by

Second Edition

Christine E. Pullar

Richard Fries

University of Leicester, Leicester, UK

Baxter Healthcare, Round Lake, Illinois, USA

Revealing the role of biological electric fields in pathophysiologies such as cancer, this book describes the importance of biological electric fields in regulating physiology at the cellular level and influencing tissue repair and regeneration. The text explains how biological electric fields are generated and how to measure them; how cells can sense these local electrical guidance cures; how bioelectricity plays a role in development, regeneration, wound repair, and cancer; and how we can harness our current understanding to promote tissue regeneration and wound repair as well as to attempt to reduce occurrences of cancer.

The second edition of Reliable Design of Medical Devices presents the basic concepts and the major issues involved in the design of medical devices, updating the information to stay at the forefront of developments in the industry. This edition includes new topics such as Six Sigma philosophy, electronic signature, material selection and biocompatibility, and quick response manufacturing. The book helps manufacturers implement a reliability assurance program while conforming to current regulations and will also help purchasers formulate effective vendor evaluation methods.

Catalog no. K11686, ISBN: 978-1-4398-3723-8 March 2011, 6 x 9, 320 pp. Suggested Price: $119.95 / £76.99

Catalog no. DK3104, ISBN: 978-0-8247-2375-0 November 2005, 6-1/8 x 9-1/4, 504 pp. Suggested Price: $179.95 / £114.00

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Textbook Textbook

Physiology, Biophysics and Biomedical Engineering

Signals and Systems Analysis In Biomedical Engineering Second Edition

Andrew W. Wood

Robert B. Northrop

Brain Sciences Institute, Hawthorn, Australia Series in Medical Physics and Biomedical Engineering

University of Connecticut, Storrs, USA Series: Biomedical Engineering

Developed from the author’s courses, this text provides an understanding of the physical principles underlying human physiology and the monitoring of physical parameters in clinical settings with biomedical engineering applications. It takes a quantitative approach to physiology and includes many problems and worked examples. A supplementary website provides MATLAB® codes and material for practical classroom activities. A solutions manual is available for qualifying instructors.

The interdisciplinary field of biomedical engineering requires its practitioners to know and master not only engineering skills, but also a diversity of material in the biological sciences. This text helps biomedical engineering students and professionals strengthen their skills in the network of applied mathematics that ties together these diverse disciplines. Based on the author’s 30 years of experience in teaching as well as his personal research on neurosensory systems, this book, now in its second edition, provides a ready source of information on the specialized mathematical techniques most useful in describing and analyzing biomedical signals.

Catalog no. C6513, ISBN: 978-1-4200-6513-8 June 2011, 7 x 10, 750 pp. Suggested Price: $99.95 / £49.99

Catalog no. K10633, ISBN: 978-1-4398-1251-8 March 2010, 6-1/8 x 9-1/4, 654 pp. Suggested Price: $99.95 / £48.99

Textbook

Porous Media Applications in Biological Systems and Biotechnology

Transport Phenomena Fundamentals Second Edition

Edited by

Joel Plawsky

Kambiz Vafai

Rensselaer Polytechnic Institute, Troy, New York, USA Series: Chemical Industries

University of California, Riverside, USA

Presenting state-of-the-art research advancements, this volume explores innovative approaches to effectively apply existing porous media technologies to biomedical applications. In each peer-reviewed chapter, world-class scientists and engineers address significant problems and discuss exciting research in biological systems. They cover various transport processes, mechanical behavior, and material properties of biological tissues from a porous media point of view. The book also presents pertinent aspects of experimental work and numerical techniques and discusses the modeling of several phenomena, including flow changes in cerebral aneurysms, biomass growth, marine systems, and tissue homeostasis and repair. Catalog no. 65416, ISBN: 978-1-4200-6541-1 August 2010, 6-1/8 x 9-1/4, 632 pp. Suggested Price: $149.95 / £95.00

This text provides a unified treatment of heat, mass, and momentum transport based on a balance equation approach. The first part of the book takes students through the balance equation in the context of diffusive transport. The second half builds upon the balance equation description of diffusive transport by introducing convective transport terms, focusing on partial rather than ordinary differential equations. A series of example modules are provided online on the author’s website, which is designed to be a living component of the course. Catalog no. 62336, ISBN: 978-1-4200-6233-5 September 2009, 7 x 10, 857 pp. Suggested Price: $129.95 / £49.99

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Textbook

Biosignal and Medical Image Processing Second Edition

Edited by

John L. Semmlow

Martin Murphy Virginia Commonwealth University, Richmond, USA

Rutgers University, Piscataway, New Jersey, USA Series: Signal Processing and Communications

This book provides the first detailed treatment of online interventional techniques for motion compensation radiotherapy. It explains how adaptive motion intervention is imaging-intensive and relies on near real-time image acquisition and processing. With a focus on the strategy of online motion compensation, the book discusses necessary motion detection methodology, repositioning methodology, and how to interpret and respond to target movement data in real time. It covers methods of detection and correction and then offers examples. It also gives attention to the distinct problems in dose planning and delivery posed by each adaptation technology.

This second edition provides a complete set of signal processing tools, including diagnostic decision-making tools and classification methods. New chapters cover adaptive neural nets, linear discriminators, and support vector machines. Examples and problems in MATLAB® encourage exploration of important properties of signal and image processing tools. An accompanying CD-ROM provides data, support subroutines, and source code from examples in the text. An educational support CD-ROM that contains a solutions manual, a suggested syllabus, and PowerPoint® presentations of all chapters is also available for instructors looking to adapt this professional reference for classroom use.

Catalog no. K11160, ISBN: 978-1-4398-2193-0 May 2011, 8-1/2 x 11, 400 pp. Suggested Price: $149.95 / £95.00

Catalog no. 62301, ISBN: 978-1-4200-6230-4 October 2008, 7 x 10, 472 pp. Suggested Price: $102.95 / £41.99

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Advanced Signal Processing Theory and Implementation for Sonar, Radar, and Non-Invasive Medical Diagnostic Systems, Second Edition

Computational Intelligence in Medical Imaging

Edited by

Techniques and Applications

Stergios Stergiopoulos

Edited by

University of Western Ontario, Canada Series: Electrical Engineering & Applied Signal Processing

Gerald Schaefer, Aboul Ella Hassanien, and Jianmin Jiang

Continuing in the bestselling tradition of the first edition, this book integrates topics of signal processing from sonar, radar, and medical system technologies by identifying their concept similarities. The second edition continues to gather the most pertinent information in advanced signal processing and provides substantial updates to the section on non-invasive medical diagnostic system applications, including intracranial ultrasound, an emerging technology that attempts to address non-invasive detection on brain injuries and stroke. The chapter titled Adapting Systems in Signal Processing represents a coherent summary of Simon Haykin’s work in the relevant field.

A compilation of the latest trends in the field, this book explores how intelligent computing can bring enormous benefit to existing technology in medical image processing and also how it can improve medical imaging research. It covers stateof-the-art research toward integrating medical image processing with artificial intelligence and machine learning approaches. The book presents a range of computational algorithms and techniques, such as neural networks, fuzzy sets, evolutionary optimization, and Monte Carlo simulations. It encompasses many important applications, including the identification of melanoma and prostate cancer analysis.

Catalog no. 62387, ISBN: 978-1-4200-6238-0 March 2009, 7 x 10, 750 pp. Suggested Price: $164.95 / £105.00

Catalog no. C6059, ISBN: 978-1-4200-6059-1 March 2009, 6-1/8 x 9-1/4, 504 pp. Suggested Price: $102.95 / £65.99

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Automated Image Detection of Retinal Pathology

Computer Vision

Herbert F. Jelinek

Edited by

Medical University of Vienna, Austria

Christopher W. Tyler

Michael J. Cree University of Waikato, Hamilton, New Zealand

Offering an array of informative examples, this book analyzes the use of automated computer techniques, such as pattern recognition, in analyzing retinal images and detecting diabetic retinopathy and its progression as well as other retinalbased diseases. It also addresses the benefits and challenges of automated health care in the field of ophthalmology. The book then details the increasing practice of telemedicine screening and other advanced applications including arteriolarvenous ratio, which has been shown to be an early indicator of cardiovascular, diabetes, and cerebrovascular risk. Catalog no. 7556, ISBN: 978-0-8493-7556-9 October 2009, 6 x 9, 384 pp. Suggested Price: $144.95 / £92.00 Available in eBook

From Surfaces to 3D Objects Smith-Kettlewell Eye Research Institute, San Francisco, California, USA

Computer Vision is the first book to take a full approach to the challenging issue of veridical 3D object representation. It introduces mathematical and conceptual advances that offer an unprecedented framework for analyzing the complex scene structure of the world. Leading theorists cover full 3D scene reconstruction, instead of the simplistic 2D planar algorithms employed in the past. They explore cutting-edge research on computational algorithms for scene analysis and present an integrated, complementary treatment of neural, behavioral, mathematical, and computational approaches. The text includes numerous graphics of complex processes, with many in color. Catalog no. K10887, ISBN: 978-1-4398-1712-4 January 2011, 6-1/8 x 9-1/4, 247 pp. Suggested Price: $89.95 / £57.99 Available in eBook

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Biomedical Imaging

Adaptive Motion Compensation in Radiotherapy

Correction Techniques in Emission Tomographic Imaging Mohammad Dawood and Klaus Schafers

Biomedical Imaging

European Institute of Molecular Imaging, Munster, Germany

The Image Processing Handbook

Xiaoyi Jiang

Sixth Edition

University of Munster, Germany Series in Medical Physics and Biomedical Engineering

John C. Russ

As they transition from preclinical to clinical settings, hybrid PET systems, such as PET-CT and PET-MRI, necessitate additional and more complex requirements for data correction. This book presents compensation techniques for a range of PET and hybrid PET imaging modalities, including newer hybrid systems currently in preclinical and small animal settings that are being developed for clinical applications. The authors address the problems encountered in emission tomography and their effects on the resulting images, providing compensation methods from the viewpoints of mathematics, computer science, and physics.

This sixth edition elucidates the tools used to acquire, process, and analyze data contained in images. Using new examples and diagrams, it presents new sections on: selecting a camera with resolution appropriate for use on light microscopes, ability of current cameras to capture raw images with high dynamic range, and imaging in more than two dimensions. The book also discusses Dmax for x-ray images and combining images with different exposure settings to further extend the dynamic range. New coverage also includes shape measurements and developments in image file searching.

Catalog no. K10659, ISBN: 978-1-4398-1298-3 May 2011, 6-1/8 x 9-1/4, 280 pp. Suggested Price: $119.95 / £76.99

Catalog no. K11875, ISBN: 978-1-4398-4045-0 February 2011, 7 x 10, 972 pp. Suggested Price: $169.95 / £108.00

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Diffuse Optical Tomography

Image Processing in Radiation Therapy

Principles and Applications

North Carolina State University, Raleigh, USA

Edited by

Huabei Jiang

Kristy Kay Brock

University of Florida, Gainesville, USA

Based on near infrared optical technologies and model-based inverse computations, DOT is an imaging method that can provide spatial distributions of intrinsic tissue optical properties through model-based reconstruction algorithms using NIR measurements along or near the boundary of tissue. This book covers almost every aspect of DOT—from mathematics, reconstruction algorithms, instrumentation, and phantom experiments to clinical applications. The text covers the fundamentals principles of DOT, including its mathematical foundations and computational methods, and explains how to set up experimental image systems, as well as how to translate laboratory studies into clinical applications.

This book provides complete descriptions of the techniques involved in medical image processing. Chapters cover topics of deformable registration, segmentation, image reconstruction, and integration of these practices into the radiation therapy environment. The four sections provide an overview of the image segmentation and reconstruction techniques using image processing across all modalities, and applications of these approaches in radiation therapy. The book also addresses the applications of registration, segmentation, and image reconstruction for radiation therapy, including adaptive radiotherapy, monitoring and tracking of treatment delivery, quantifying accuracy, and visualizing results.

Catalog no. K12111, ISBN: 978-1-4398-4757-2 December 2010, 6-1/8 x 9-1/4, 375 pp. Suggested Price: $129.95 / £82.00

Catalog no. K11476, ISBN: 978-1-4398-3017-8 June 2011, 6-1/8 x 9-1/4, 400 pp. Suggested Price: $129.95 / £82.00

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Textbook

Electronics for Radiation Detection Edited by

Image Processing with MATLAB® Applications in Medicine and Biology Omer Demirkaya

Krzysztof Iniewski

King Faisal Specialist Hospital & Res. Ctr, Riyadh, Saudi Arabia

CMOS Emerging Technologies Inc., Vancouver, British Columbia, Canada Series: Devices, Circuits, and Systems

Musa Hakan Asyali Erciyes University, Kayseri, Turkey

This book presents valuable information that will help integrated circuit (IC) designers and other electronics professionals take full advantage of the tremendous developments and opportunities associated with this burgeoning field. The information presented here helps readers optimize use of electronic detection equipment and stimulate further interest in its development. It explores the design of semiconductor detectors, integrated circuits, and other electronics used in radiation detection, and explains how circuits are built to deal with radiation, focusing on practical information regarding how they are being used, rather than simply mathematical details.

This text explains complex, theory-laden topics in image processing through examples and MATLAB® algorithms. It provides these algorithms to help scientists and researchers quickly identify the most effective solution method for a particular problem at hand. The authors emphasize three-dimensional processing and analysis as well as statistical and stochastic modeling. They cover the new areas of nonlinear diffusion filtering and PDE-based image filtering, address relatively advanced topics, such as Markov random field-based image segmentation, and highlight applications with images from medicine and biology. They also include real-world examples and exercises in every chapter.

Catalog no. K10847, ISBN: 978-1-4398-1648-6 July 2010, 6-1/8 x 9-1/4, 378 pp. Suggested Price: $149.95 / £95.00

Catalog no. 9246, ISBN: 978-0-8493-9246-7 December 2008, 6-1/8 x 9-1/4, 451 pp. Suggested Price: $102.95 / £45.99

Prasanna K. Sahoo University of Louisville, Kentucky, USA

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George C. Kagadis

Edited by

University of Patras, Rion, Greece

Lihong V. Wang

Steve G. Langer

Washington University, St. Louis, Missouri, USA Series: Optical Science and Engineering

Mayo Clinic, Rochester, New York, USA

This book reflects the considerable advances made in recent years, most notably in radiology, which is the source of most imaging modalities. It also addresses other specialties, such as pathology, cardiology, dermatology, and surgery, which have now adopted the use of digital images. The text discusses basic imaging informatics protocols, picture archiving and communication systems, and the electronic medical record. It also details key instrumentation and data mining technologies used in medical imaging informatics as well as practical operational issues, such as procurement, maintenance, teleradiology, and ethics. Catalog no. K11526, ISBN: 978-1-4398-3124-3 May 2011, 8-1/2 x 11, 500 pp. Suggested Price: $149.95 / £95.00 Available in eBook

While photoacoustic imaging is probably the fastest growing biomedical imaging technology, this is the first comprehensive volume in this emerging field to cover both the physics and the noninvasive applications that are changing diagnostic medicine. Photoacoustic Imaging and Spectroscopy examines the state of the art in this exciting area of research, offering complete coverage of photoacoustic, optoacoustic, and thermoacoustic imaging. Featuring 200 illustrations, this volume illustrates the superiority of photoacoustic images over x-ray and ultrasonic images. It also discusses all potential applications of photoacoustic technology, including biomedical applications. Catalog no. 59912, ISBN: 978-1-4200-5991-5 March 2009, 8-1/2 x 11, 518 pp. Suggested Price: $154.95 / £99.00 Available in eBook

Knowledge-Driven Medicine A Machine Learning Approach Edited by

Textbook

The Physics of Medical Imaging

R. Bharat Rao

Second Edition

Siemens, Malvern, Pennsylvania, USA

Edited by

Glenn Fung

S. Webb

Siemens Medical Solutions, Madison, Wisconsin, USA

Romer Rosales

Institute of Cancer Research and Royal Marsden NHS Trust, UK Series in Medical Physics and Biomedical Engineering

Focusing on several recent, novel machine learning automatic algorithms, this reference provides the first source on the use of machine learning methods in designing computer-aided diagnosis (CAD) systems. It proposes a framework for CAD problems, presents the technical issues involved when building classifiers, and provides the appropriate machine learning techniques to address these problems. The book also includes results and concrete examples for different diseases and imaging modalities. It provides a useful tool for researchers and students in the biomedical sciences and machine learning as well as for advanced courses on CAD and/or medical informatics.

This updated text explains the physical principles governing medical imaging. It places different techniques in context with each other to provide historical perspective and insight on future developments. It also illustrates techniques through examples of clinical imaging applications. The book covers the use of x-rays in diagnostic radiology and computed tomography in radiotherapy planning. It also discusses the tools and techniques of radioisotope, ultrasound, magnetic resonance, infrared, and optical imaging, along with the mathematics involved in image formation and processing, image interpretation, and computational requirements of imaging systems.

Catalog no. K11767, ISBN: 978-1-4398-3887-7 June 2011, 6-1/8 x 9-1/4, 300 pp. Suggested Price: $89.95 / £54.99

Catalog no. IP743, ISBN: 978-0-7503-0573-0 June 2011, 6-1/8 x 9-1/4, 600 pp., Soft Cover Suggested Price: $69.95 / £44.99

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Nuclear Medicine Physics

Textbook

Edited by

The Science of Imaging

Joao Jose De Lima

Second Edition

IBILI Biophysics Institute, Coimbra, Portugal Series in Medical Physics and Biomedical Engineering

Graham Saxby

Edited by a renowned international expert in the field, Nuclear Medicine Physics offers an up-to-date, state-of-the-art account of the physics behind the theoretical foundation and applications of nuclear medicine. It covers important physical aspects of the methods and instruments involved in modern nuclear medicine, along with related biological topics. The book discusses the production of radioisotopes and radiopharmaceuticals, positron physics and positron applications in medicine and biology, and modern radiation detectors and measuring methods. It also explores systems in nuclear medicine, imaging methodologies, dosimetry, and the biological effects of radiation.

Updated and expanded to keep pace with the digital revolution, the new edition of this critically acclaimed work provides a comprehensive exploration of imaging science. Extensively illustrated, the second edition covers the fundamental laws of physics as well as the cutting-edge techniques defining current and future directions in the field. This accessible introduction takes readers on a grand tour of imaging. Starting with the fundamentals of light and basic cameras, the author journeys through television and holography to advanced scientific and medical imaging. He highlights essential formulas, while keeping the complex mathematics to a minimum.

Catalog no. C7958, ISBN: 978-1-58488-795-9 November 2010, 6-1/8 x 9-1/4, 524 pp. Suggested Price: $149.95 / £95.00

Catalog no. K10653, ISBN: 978-1-4398-1286-0 November 2010, 8-1/2 x 11, 352 pp. Suggested Price: $69.95 / £36.99

Retired, University of Wolverhampton, UK

Available in eBook For more information and a complete list of titles, visit us at www.crcpress.com

Biomedical Imaging

Edited by

Photoacoustic Imaging and Spectroscopy

Informatics in Medical Imaging

Semiconductor Radiation Detection Systems Edited by

Krzysztof Iniewski

Biomedical Imaging / Biophysics

CMOS Emerging Technologies Inc., Vancouver, British Columbia, Canada Series: Devices, Circuits, and Systems

Edited by

An essential resource for anyone serious about detectors and electronics in the healthcare sector, this book addresses the state-of-the-art in the design of semiconductor detectors and integrated circuits in the context of medical imaging using ionizing radiation. It includes new, exciting opportunities in X-ray detection, Computer Tomography (CT), bone dosimetry, and nuclear medicine applications such as PET and SPECT. In addition to medical imaging, the book explores other applications of semiconductor radiation detection systems in areas related to security, such as luggage scanning, dirty bomb detection, and border control.

This volume describes the structural and energetic aspects of molecular interactions responsible for chiral recognition. Topics discussed include optical spectroscopy in jet-cooled conditions in neutral chiral molecules and complexes, and mass spectrometry approaches to chiral recognition in ionic complexes. These include the study of the stability of supramolecular chiral host-guest adducts, the study of chiral catalysts and chiral selectors, the use of small DNA sequences as auxiliaries for discriminating the enantiomers of amino-acids, and the probe of the chirality of a single amino acid within a peptide chain.

Catalog no. K10214, ISBN: 978-1-4398-0385-1 May 2010, 6-1/8 x 9-1/4, 400 pp. Suggested Price: $149.95 / £95.00

Anne Zehnacker CNRS, Laboratoire de Photophysique Moleculaire, Orsay, France

Catalog no. 82272, ISBN: 978-1-4200-8227-2 May 2010, 6-1/8 x 9-1/4, 247 pp. Suggested Price: $99.95 / £63.99 Available in eBook

Available in eBook

Signal Processing in Magnetic Resonance Spectroscopy with Biomedical Applications

Textbook

Engineering Genetic Circuits Chris J. Myers

Karolinska Institute, Stockholm, Sweden

University of Utah, Salt lake City, USA Series: Chapman & Hall/CRC Mathematical & Computational Biology

Addressing the critical need in clinical oncology for robust and stable signal processing in MRS, this book explores cutting-edge theory-based innovations for obtaining reliable quantitative information from MR signals for cancer diagnostics. By defining the natural framework of signal processing using the well-established theory of quantum physics, it illustrates how advances in signal processing can optimize MRS. Applying the fast Padé transform (FPT) to several problems in oncology diagnostics, including ovarian, breast, and prostate cancer, the book examines the remarkable ability of the FPT to unambiguously quantify isolated, tightly overlapped, and nearly confluent resonances.

This text presents the modeling, analysis, and design methods for systems biology. It discusses how to examine experimental data to learn about mathematical models, develop efficient abstraction and simulation methods to analyze these models, and use analytical methods to design new circuits. The author reviews basic molecular biology and biochemistry principles, covers several methods for modeling and analyzing genetic circuits, and uses phage lambda as an example throughout to help illustrate the methods. He also explores the emerging area of synthetic biology. iBioSim software, lecture slides, and a solutions manual are available on the author’s website.

Catalog no. K10321, ISBN: 978-1-4398-0644-9 January 2010, 6-1/8 x 9-1/4, 468 pp. Suggested Price: $119.95 / £76.99

Catalog no. C3244, ISBN: 978-1-4200-8324-8 July 2009, 6-1/8 x 9-1/4, 306 pp. Suggested Price: $71.95 / £45.99

Dzevad Belkic and Karen Belkic

Chiral Recognition in the Gas Phase

Available in eBook

FLIM Microscopy in Biology and Medicine Chemical Physics

Edited by

Electrons and Excitations

University of Virginia, Charlottesville, USA

Ammasi Periasamy

Sven Larsson

Robert M. Clegg

Chalmers University of Technology, Gothenburg, Sweden

University of Illinois, Urbana, USA

Addressing students of theoretical and quantum chemistry and their counterparts in physics, this book introduces chemical physics as a gateway to fields such as photo physics, solid state physics, and electrochemistry. Offering relevant background in theory and applications, it covers the foundations of quantum mechanics and molecular structure, as well as more specialized topics such as transfer reactions and photochemistry. It employs numerous case studies and applications to quantum chemical problems in real, modern research including excited electronic states, biological metal centers, and condensed phase experiments. Math problems and solutions are available online.

Fluorescence lifetime imaging (FLIM) is a powerful new tool for advanced quantitative analysis. Its high contrast and sensitivity allow for the detection of signals at the single molecule level. After an overview of basic principles of fluorescence, microscopy, and FLIM, this book discusses probes, dynamic and video rate FLIM imaging, laser scanning confocal FLIM, spectral lifetime imaging, nonlinear curve-fitting methods, global FLIM data analysis, and new approaches in data analysis. Widely recognized as pioneers in the field, the editors offer a summary chapter on current FLIM applications.

Catalog no. K11167, ISBN: 978-1-4398-2251-7 June 2011, 6-1/8 x 9-1/4, 360 pp. Suggested Price: $99.95 / £63.99

Catalog no. C7890, ISBN: 978-1-4200-7890-9 July 2009, 7 x 10, 472 pp. Suggested Price: $102.95 / £65.99 Available in eBook

Available in eBook For more information and a complete list of titles, visit us at www.crcpress.com

Optical Tweezers Methods and Applications

Handbook of Physics in Medicine and Biology Edited by

Edited by

Miles J. Padgett University of Glasgow, Scotland

Justin Molloy MRC National Institute for Medical Research, London, UK

University of North Carolina at Charlotte, USA

This volume covers materials associated with replacement or repair of tissues or entire tissue structures. The book begins with a description of specific biological features and delves into the physics of explicit anatomical structures starting with the cell. The contents are then organized by organ type and biological function. In addition to physical descriptions, each chapter discusses principles of related diagnostic methods and technological aspects of therapeutic applications. A final section on regenerative engineering emphasizes biochemical and physiochemical factors important in improving or replacing biological functions. Catalog no. 75241, ISBN: 978-1-4200-7524-3 April 2010, 8-1/2 x 11, 548 pp. Suggested Price: $149.95 / £95.00 Available in eBook

David McGloin University of Dundee, Scotland UK

Bringing together many landmark papers on the field, this compendium covers the techniques and applications of optical tweezers. It covers Arthur Ashkin’s initial work on radiation pressure and the immediate progress following his seminal demonstration. The expert contributors explore recent biological, colloidal, and microfluidic applications. They also analyze the mechanisms underpinning basic tweezer force and the interaction among many particles held within multiple tweezer systems. In addition, they explain the conversion of optical tweezers into optical spanners as well as the creation of holographic tweezers using spatial light modulators. Catalog no. C7412, ISBN: 978-1-4200-7412-3 June 2010, 8-1/2 x 11, 508 pp. Suggested Price: $149.95 / £83.00 Available in eBook

Textbook

Introduction to Experimental Biophysics Biological Methods for Physical Scientists Jay Nadeau McGill University, Montreal, Quebec, Canada

A practical companion for physical scientists seeking to move into wet laboratory experiments and biological research areas, this book gives a clear understanding of what is experimentally feasible. The text begins with the simpler, essential methods and builds gradually to more advanced techniques. It is organized into three main sections that address genes, proteins, and expression systems. This structure allows readers to follow the steps involved in the production of nucleic acids and proteins and the different levels of purification required for each type of analysis. Catalog no. K11452, ISBN: 978-1-4398-2953-0 May 2011, 7 x 10, 350 pp., Soft Cover Suggested Price: $79.95 / £49.99

Textbook

Quantitative Understanding of Biosystems An Introduction to Biophysics Thomas M. Nordlund University of Alabama at Birmingham, USA

This intermediate-level text covers the biophysics of macromolecules and subcellular structures interactions with light from a quantitative perspective. The author emphasizes mathematical and computational approaches to study the properties and physical behavior of biomolecules and nanostructures. He provides detailed coverage of key principles of statistical mechanics and quantum effects that are important for biological function, as well as light interactions with supramolecular structures. The book incorporates learning tools, such as problem sets, exercises, review material, and learning objectives, and includes discussions of topics that are often neglected, such as structural hierarchy. Catalog no. 89772, ISBN: 978-1-4200-8972-1 February 2011, 8-1/2 x 11, 583 pp. Suggested Price: $89.95 / £57.99

Introduction to Proteins Structure, Function, and Motion Amit Kessel Es-is Technologies Ltd., Givatayim, Israel

Nir Ben-Tal

Textbook

Statistical Physics of Biomolecules

Tel Aviv University, Israel Series: Chapman & Hall/CRC Mathematical & Computational Biology

An Introduction

With more than 350 color images throughout, this text presents a unified, in-depth treatment of the relationship between the structure, dynamics, and function of proteins. Taking a structural–biophysical approach, the authors discuss the molecular interactions and thermodynamic changes that transpire in these highly complex molecules. They use numerous proteins as examples to illustrate principles and demonstrate how proteins can be analyzed in multiple ways. The text refers to many everyday applications of proteins and enzymes in medical disorders, drugs, toxins, chemical warfare, and animal behavior.

It is essential for modern students of molecular behavior to understand the statistical/chemical physics at the heart of modern molecular science. But traditional presentations of this material are often difficult to penetrate. This volume brings “down to earth” some of the most intimidating but important theories of molecular biophysics. Students build understanding by focusing on topics such as probability theory, low-dimensional models, and the simplest molecular systems. The book’s accessible development of equilibrium and dynamical statistical physics makes this a valuable text for students with limited physics and chemistry backgrounds.

Catalog no. K10533, ISBN: 978-1-4398-1071-2 December 2010, 7 x 10, 654 pp. Suggested Price: $79.95 / £49.99 Available in eBook

Biophysics

Robert Splinter

Daniel M. Zuckerman University of Pittsburgh, Pennsylvania, USA

Catalog no. 73788, ISBN: 978-1-4200-7378-2 June 2010, 6-1/8 x 9-1/4, 356 pp. Suggested Price: $89.95 / £46.99

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Vibrational Spectroscopy for Tissue Analysis

Biocatalysis and Agricultural Biotechnology

Ihtesham Ur Rehman and Zanyar Movasaghi

Edited by

Queen Mary University of London, UK

Ching T. Hou

Shazza Rehman

United States Department of Agriculture, Peoria, Illinois, USA

Biophysics / Biotechnology

St. George’s Healthcare NHS Trust, West Yorkshire, UK Series in Medical Physics and Biomedical Engineering

Jei-Fu Shaw

This book presents a variety of vibrational spectroscopic techniques, focusing on Raman and Fourier transform infrared (FTIR) spectroscopy and their use in noninvasive optical tissue diagnosis. It covers the most recent research in this area to create a unique database of different chemical bands and their assignments of spectral bands. The text explores the spectroscopic investigation of different tissues and samples, including breast tissue, lung tissue, and brain tissue. The authors provide definitions of peak frequencies as well as other aspects of spectroscopy that could be helpful to a wide range of scientists.

With contributions from 55 distinguished international experts comprising all sectors of academia, industry, and government research institutes — a virtual who’s who among biocatalysis scientists — this book brings together current advances and in-depth reviews of biocatalysis and agricultural biotechnology, emphasizing bio-based products and agricultural biotechnology. Divided into two sections, it covers the latest research on improvements of agronomic and microbial traits and bio-based industry products. A reference for industrial science researchers, this text also serves as a reference for graduate students across bioscience.

Catalog no. K11629, ISBN: 978-1-4398-3608-8 June 2011, 6-1/8 x 9-1/4, 432 pp. Suggested Price: $159.95 / £99.00

Catalog no. 77031, ISBN: 978-1-4200-7703-2 April 2009, 6-1/8 x 9-1/4, 442 pp. Suggested Price: $185.95 / £119.00

Available in eBook

Textbook

Adhesion Molecules

National Chung Hsing University, Taichung, Taiwan

Biotechnology Operations Principles and Practices

Victor R. Preedy

Michael J. Roy

King’s College, London, UK

University of Wisconsin-Madison, USA

This book covers the structure and classification of adhesion molecules, immunohistochemical localization, junctional, functional and inflammatory adhesion molecules, and molecular imaging. It discusses adhesion molecules in relation to signaling pathways, gene expression, arginine, stem cells, neutrophil migration, leukocytes decompression sickness, ischemia reperfusion injury, diabetes, obesity, metabolic syndrome, weight loss, hypoxia, kidney disease, smoking, osteoprotegerin, tumors, bioinformatics, high-throughput technologies, chemotherapy, hematopoiesis, lipoproteins, fatty acids, atrial fibrillation, and heart disease, and the brain and dementia.

Based on the author’s five years of teaching, this book introduces key biotechnology developments covering the critical elements of such as project management, regulatory affairs, quality assurance, biomanufacturing, quality control, nonclinical safety testing, and clinical evaluation. The author discusses these subjects in relation to development planning, process and pathways, management of integrated projects and the business and economic aspects of development. It describes the functional areas that must be successfully integrated to bring a biotechnology product to market, using simple language and explanatory figures.

Catalog no. N10265, ISBN: 978-1-57808-671-9 April 2010, 6 x 9, 520 pp. Suggested Price: $149.95 / £95.00

Catalog no. K11486, ISBN: 978-1-4398-3027-7 March 2011, 6-1/8 x 9-1/4, 416 pp. Suggested Price: $99.95 / £63.99

Available in eBook

Applied Optics Fundamentals and Device Applications

Biotechnology

Nano, MOEMS, and Biotechnology

A Comprehensive Training Guide for the Biotechnology Industry

Mark A. Mentzer

Syed Imtiaz Haider and Anika Ashtok

U.S. Army Aberdeen Test Center, Maryland, USA

Julphar Gulf Pharm. Industries, United Arab Emirates

Providing an interdisciplinary look at optics technology, this book investigates the connection between nanotechnology, MOEMS, and biotechnology. It covers fundamental relationships and system applications and includes design examples and numerous useful references. The author discusses emerging technologies, such as MEMS, MOEMS, nanotechnology, biotechnology, fiber optic sensing, and integrated optics, along with specialized military applications. He uses case studies to provide a comprehensive understanding of the way in which emerging optics technologies are applied in the marketplace.

This guide provides concise information covering the concepts and techniques needed to ensure product consistency, potency, efficacy, and safety in the biotechnology and biopharmaceutical industries. A valuable quality tool for both new and existing manufacturers, this text presents step-by-step guidance for optimizing research and maximizing expenditures so as to gain a competitive advantage. It discusses ways to avoid delays to market, reduce product and process failures, develop skilled employees, and maintain both local and international regulatory compliance. The book includes a companion CD-ROM that offers customizable training information.

Catalog no. K11430, ISBN: 978-1-4398-2906-6 April 2011, 6-1/8 x 9-1/4, 424 pp. Suggested Price: $129.95 / £78.99 Available in eBook

Catalog no. 84488, ISBN: 978-1-4200-8448-1 April 2009, 7 x 10, 868 pp., Soft Cover Suggested Price: $102.95 / £65.99 Available in eBook

For more information and a complete list of titles, visit us at www.crcpress.com

New Technologies and Applications

Second Edition - 2 Volume Set (Print Version)

Edited by

Narayan S. Hosmane

Dennis R. Heldman

Northern Illinois University, Dekalb, USA

Heldman Associates, Mason, Ohio, USA

The field of boron chemistry research has grown substantially in recent years. However, finding reliable information on these advances has required searching across a vast amount of research literature. This book is the first of its kind to comprehensively cover the latest in boron science in a single source. The text addresses the application of boron in chemistry, industry, medicine, and pharmacology and explains its role in such problems as catalysis, hydroboration, superconductors, materials, and magnetic and nonmagnetic nanoparticles as well as in medical applications such as cancer therapy.

This expansive resource covers the development and design of procedures, equipment, and systems utilized in the production and conversion of raw materials into food and nonfood consumer goods. With nearly 2,000 photographs, figures, tables, and equations, including 128 color figures--the book emphasizes and illustrates the various engineering processes associated with the production of materials with agricultural origin. With contributions from more than 350 experts and featuring more than 200 entries and 3600 references, this is the largest and most comprehensive guide on raw production technology.

Catalog no. K11300, ISBN: 978-1-4398-2662-1 March 2011, 6-1/8 x 9-1/4, 440 pp. Suggested Price: $159.95 / £99.00

Catalog no. K10554, ISBN: 978-1-4398-1111-5 October 2010, 8-1/2 x 11, 2114 pp. Suggested Price: $636.00 / £507.00

Available in eBook

Colloids in Biotechnology Edited by

Encyclopedia of Biotechnology in Agriculture and Food

Biotechnology

Boron Science

Encyclopedia of Agricultural, Food, and Biological Engineering

Edited by

Dennis R. Heldman Heldman Associates, Mason, Ohio, USA

Monzer Fanun Al-Quds University, East Jerusalem, Palestine Series: Surfactant Science

Colloids show great potential in a wide variety of applications, including drug delivery and medical imaging. This volume describes developments in the field of biotechnological applications in the past decade and bridges the gap between these research efforts and commercially viable options. The authors discuss new types of biosurfactants; mixtures of surfactants; and peptides, proteins, and polyelectrolytes. They also describe the formation and properties of magnetic colloids and review their applications in chemical biology and medicine. They highlight current progress in the design of self-assembled materials for biotechnology, and they also cover the formation of nanofibres and the use of sol-gel technology in biology. Catalog no. K11511, ISBN: 978-1-4398-3080-2 September 2010, 7 x 10, 547 pp. Suggested Price: $159.95 / £99.00 Available in eBook

Digital Microfluidic Biochips Design Automation and Optimization

Matthew B. Wheeler University of Illinois, Urbana, USA

Dallas G. Hoover University of Delware, Newark, USA

Focusing on the science and applications of molecular biology to agriculture and foods, this encyclopedia describes the new tools for use in the production of raw agricultural materials and the manufacturing of food products. Two hundred entries cover areas such as cloned animals, genetically modified and droughtresistant plants, biodiversity, and nutritionally enhanced foods. The encyclopedia explores media coverage of biotechnology, governmental regulations associated with it, consumer acceptance, and environmental issues. Illustrations and comprehensive references complement the text. This reference is also available in an online format. Catalog no. DK271X, ISBN: 978-0-8493-5027-6 July 2010, 8-1/2 x 11, 784 pp. Suggested Price: $399.95 / £254.00

Textbook

Duke University, Durham, North Carolina, USA

Environmental Microbiology for Engineers

Tao Xu

Volodymyr Ivanov

Krishnendu Chakrabarty Cisco Systems, Cary, North Carolina, USA

Nanyang Technological University, Singapore

Microfluidics-based biochips combine electronics with biochemistry for newly emerging application areas such as point-of-care medical diagnostics, on-chip DNA analysis, automated drug discovery, and protein crystallization. This book envisions an automated design flow for microfluidic biochips. It offers newly designed automation solutions for problems unique to digital microfluidics. The authors provide a comprehensive methodology for the automated design, test, and use of robust and low-cost manufactured digital microfluidic systems. Using real-life bioassays as examples, they offer a comprehensive set of practical methodologies and tools for chip design and manufacture.

Designed specifically for engineers with little or no biology training, this book covers diversity and function of microorganisms in environmental engineering systems, environmental bioengineering processes, applied microbial genetics and molecular biology, microbiology of water and wastewater treatment, biotreatment and bioremediation, and microbial monitoring. It also explores biocorrosion of the constructions, biodeterioration of the materials, biocementation and bioclogging of soil, biopollution of indoor environment, and biofouling of the facilities. Each chapter includes quizzes and tutorials with instructor’s solutions available in a separate solutions manual with qualifying course adoption.

Catalog no. K11010, ISBN: 978-1-4398-1915-9 May 2010, 6-1/8 x 9-1/4, 213 pp. Suggested Price: $139.95 / £89.00

Catalog no. 92340, ISBN: 978-1-4200-9234-9 November 2010, 6-1/8 x 9-1/4, 438 pp. Suggested Price: $99.95 / £63.99

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Textbook

Fundamentals of Microfluidics and Lab on a Chip for Biological Analysis and Discovery

Textbook

Paul C.H. Li

Dimitris Dogramatzis

Healthcare Biotechnology A Practical Guide

Biotechnology

Simon Fraser University, Burnaby, British Columbia, Canada

Dogramatzis Pharmacy, Athens, Greece

This volume focuses on all key aspects of the microfluidic lab-on-a-chip technologies to offer an exceptionally cohesive overview of the science, its limitations, breakthroughs made over the years, and currently emerging advances. The book emphasizes analytical applications of microfluidic technology and presents in-depth coverage of micromachining methods, microfluidic operations, chemical separations, sample preparation and injection methods, detection technology, and various chemical and biological analyses. Other topics of interest include the use of polymeric chips, fluid flow valve and control, single-cell analysis, DNA and RNA amplification techniques, DNA hybridization, immunoassays, and enzymatic assays.

This text is a resourceful practical guide that assists all healthcare related biotech professionals in their day-to-day activities. The book contains chapters on bioeconomy, biolicensing, biofinance, biopartnering, biodrug research, biomarketing planning, biopromotion, product life cycle management, and biobusiness models, among others. Written by a well-established professional and registered pharmacist, this reference is appropriate for graduate students and industry professionals. It contains over 350 tables and figures and end-of-section problems accompany each chapter. There are also extensive references following each chapter to enhance further study.

Catalog no. K10977, ISBN: 978-1-4398-1855-8 February 2010, 7 x 10, 418 pp., Soft Cover Suggested Price: $99.95 / £38.99

Catalog no. K12108, ISBN: 978-1-4398-4746-6 December 2010, 6-1/8 x 9-1/4, 768 pp. Suggested Price: $99.95 / £63.99

Gene Biotechnology Third Edition Esperion Therapeutics, Inc., Ann Arbor, Michigan, USA

Illustrated Dictionary of Biotechnology

Peter B. Kaufman and Michael J. Welsh

Himanshu Arora

University of Michigan, Ann Arbor, USA

Ane Books, India

The third edition of this popular reference covers a variety of techniques related to gene manipulation, including DNA isolation, preparation, screening, and analysis. Topics range from very basic methods to current and sophisticated technologies, including methodologies created and tested by the authors. Other topics include approaches to grant funding and SiRNA technology. The authors offer detailed, step-by-step explanations of protocols and helpful troubleshooting guides. This edition features new techniques for every chapter, as well as several new chapters.

Helping to support a common language in this rapidly evolving field, the Illustrated Dictionary of Biotechnology includes a range of terms wide enough to satisfy the needs of any researcher, clinician, lawyer, investor, student, or instructor whose work involves contact with new advances in science and medicine. In clear and lucid English, it provides straightforward definitions and invaluable background information so that even complex terms require only a rudimentary understanding of the life sciences. Extensive cross-referencing expands individual definitions, enabling readers to follow a chosen theme. Illustrations are included where they enhance understanding.

William Wu

Catalog no. K12153, ISBN: 978-1-4398-4830-2 May 2011, 6-1/8 x 9-1/4, 584 pp. Suggested Price: $149.95 / £95.00

Handbook of Analysis of Oligonucleotides and Related Products Edited by

Jose V. Bonilla

Catalog no. N10040, ISBN: 978-1-4398-0173-4 April 2009, 6-1/8 x 9-1/4, 450 pp., Soft Cover Suggested Price: $61.95 / £39.99

Textbook

Introduction to Biology and Biotechnology

Girindus America, Cincinnati, Ohio, USA

Second Edition

G. Susan Srivatsa

K. Vaidyanath, K. Pratap Reddy, and K. Satya Prasad

ElixinPharma, Encinitas, California, USA

Osmania University, Hyderabad, India

A first-of-its-kind handbook, this text covers all the analytical techniques and methods commonly employed with oligonucleotides. With contributions from experts in the field, this handbook presents comprehensive coverage for analytical chemists, biochemists, biotechnologists, molecular biologists, and geneticists on the latest analytical technologies currently available. Topics covered include purity determination by HPLC, molecular weight determination, determination of hygroscopicity, analysis of bioburden, and analyses of ionic species by ion chromatography. A chapter on PAT and coverage of bioanalytical techniques is also included, and illustrations of analytical techniques and outputs are presented to aid with comprehension.

Including recent advances, this edition focuses on sustainable development and human welfare in biology, genetics, microbial biotechnology, and molecular medicine. While written for engineers specializing in biotechnology, those in agriculture, veterinary science, and medicine will find new information relevant to their practice. It links biological principles to plant, animal, environmental, industrial, and medical biotechnologies, discusses concepts of genetics and molecular biology, and examines developments in the production of biopolymers, vaccines, gene therapy, bioremediation, biofuels, and biofertilizers.

Catalog no. K11050, ISBN: 978-1-4398-1993-7 February 2011, 7 x 10, 492 pp. Suggested Price: $139.95 / £89.00

Catalog no. N10069, ISBN: 978-1-4398-0724-8 February 2009, 7 3/8 x 9 1/4, 625 pp. Suggested Price: $82.95 / £42.99

Available in eBook For more information and a complete list of titles, visit us at www.crcpress.com

The Metabolic Pathway Engineering Handbook Two-Volume Set

OMICS Biomedical Perspectives and Applications

Stanford University, California, USA Series: Metabolic Pathway Engineering Handbook

Debmalya Barh Institute of Integrative Omics and Applied Biotechnology, West Bengal, India

Christina Smolke, who recently developed a novel way to churn out large quantities of drugs from genetically modified brewer’s yeast, is regarded as one of the most brilliant new minds in biomedical engineering. In this handbook, she brings together pioneering scientists from dozens of disciplines to provide a complete record of accomplishment in metabolic pathway engineering. With a wealth of cutting-edge material, this work is an invaluable resource for those seeking to add their own contributions. Organized by topic, this reference is available as two volumes that can be purchased individually or as a set.

Omics is a general term for science and engineering disciplines involved in analyzing the interaction of biological informational objects in various omes. Reflecting the explosion of research and development in this area, this volume explores applications of omics in bioinformatics, cancer research and therapy, diabetes research, plant science, molecular biology, and neurosciences. Worldwide experts have each written specific chapters in this comprehensive volume that highlight proteomics and genomics. Detailed references are included at the end of each chapter to enhance further study.

Buy the set and save!

Catalog no. K12277, ISBN: 978-1-4398-5008-4 June 2011, 6 x 9, 400 pp. Suggested Price: $139.95 / £89.00

Catalog no. 3923, ISBN: 978-0-8493-3923-3 August 2009, 7 x 10, 1259 pp., Suggested Price: $257.95 / £164.00

Also available in individual volumes

Fundamentals This volume explores balances and reaction models, the regulation of metabolic pathways, and genome scale and multiscale modeling tools. In addition, it covers the development of appropriate hosts for metabolic engineering, including the use of Escherichia coli, Bacillus subtilis, Streptomyces, yeast, filamentous fungi, and mammalian cells using cell culture. Catalog no. K10164, ISBN: 978-1-4398-0296-0 July 2009, 7 x 10, 678 pp. Suggested Price: $164.95 / £102.00

Tools and Applications This volume delves into evolutionary tools as well as gene expression tools for metabolic pathway engineering. It covers applications of emerging technologies including recent research genome-wide technologies, DNA and phenotypic microarrays, and proteomics tools for experimentally determining flux through pathways. This volume also looks at emerging applications for producing fine chemicals, drugs, and alternative fuels. Catalog no. 77651, ISBN: 978-1-4200-7765-0 July 2009, 7 x 10, 581 pp. Suggested Price: $164.95 / £102.00 Both available in eBook

Micro and Nano Techniques for the Handling of Biological Samples Jaime Castillo, Winnie Edith Svendsen, and Maria Dimaki

Available in eBook

Support Vector Machines and Their Application in Chemistry and Biotechnology Yizeng Liang Hunan University, Changsha, China

Qing-Song Xu Central South University, Changsha, China

Support vector machines (SVMs), a promising machine learning method, is a powerful tool for chemical data analysis and for modeling complex physicochemical and biological systems. It is of growing interest to chemists and has been applied to problems in such areas as food quality control, chemical reaction monitoring, metabolite analysis, QSAR/QSPR, and toxicity. This book presents the theory of SVMs in a way that is easy to understand, regardless of mathematical background. It includes simple examples of chemical and OMICS data to demonstrate the performance of SVMs and compares SVMs to other traditional classification/regression methods. Catalog no. K11127, ISBN: 978-1-4398-2127-5 March 2011, 6-1/8 x 9-1/4, 201 pp. Suggested Price: $119.95 / £76.99 Available in eBook

3D Cell-Based Biosensors in Drug Discovery Programs Microtissue Engineering for High Throughput Screening William S. Kisaalita University of Georgia, Athens, USA

The techniques and tools used to understand many biological problems must be able to handle biological material without damaging or altering its natural state. This timely book assesses various micro and nano techniques currently available to handle these materials. It shows how the techniques can effectively manipulate biological samples and highlights the advantages and shortcomings of each technique. The authors also help readers to understand how the manipulation tools work and to determine the appropriate tool for their needs.

This book is based upon cutting-edge research conducted in the author’s lab (Cellular Bioengineering), which over the past decade has developed a number of sophisticated techniques to facilitate use of 3D cell based assays or biosensors. This book uses data from peer-reviewed publications to conclusively justify use of 3D cell cultures in cell-based biosensors (assays) for HTS. The majority of assays performed in accelerated drug discovery processes are biochemical in nature, but there is a growing demand for live cell-based assays. Unlike biochemical ones, cellular assays are functional approximations of in vivo biological conditions and can provide more biologically relevant information.

Catalog no. K11354, ISBN: 978-1-4398-2743-7 June 2011, 6-1/8 x 9-1/4, 496 pp. Suggested Price: $139.95 / £89.00

Catalog no. 73494, ISBN: 978-1-4200-7349-2 June 2010, 6-1/8 x 9-1/4, 404 pp. Suggested Price: $129.95 / £82.00

Available in eBook

Technical University of Denmark, Lyngby

Biotechnology

Christina Smolke

For more information and a complete list of titles, visit us at www.crcpress.com

Advances in Chromatography Edited by

Eli Grushka, The Hebrew University of Jerusalem, Israel Nelu Grinberg, Boehringer-Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA Series: Advances in Chromatography

Chiral Separations by Capillary Electrophoresis Edited by

Ann Van Eeckhaut and Yvette Michotte Vrije Universiteit, Brussels, Belgium Chromatographic Science Series

Methods & Instrumentation

Advances in Chromatography Volume 49 For more than four decades, scientists and researchers have relied on this series for the most up-to-date information on chromatographic methods and applications. This volume presents timely and cutting-edge reviews on a variety of related topics. Each author’s clear presentation of topics and vivid illustrations make the material accessible to those at all levels of experience. This edition covers method harmonization, strategies for rapid HPLC development, multidimensional ion chromatography, quantitative in silico analysis, mechanistic aspects of chiral discrimination on protein phases, novel materials for chromatographic analysis, and advances in CE-MS based glycoanalysis.

This volume provides a comprehensive, up-to-date overview of the principles of chiral separation by capillary electrophoresis and the different chiral selectors available. It discusses the most important as well as several new chiral selectors used in capillary electrophoresis. The book reviews recent pharmaceutical and biomedical applications and explores novel techniques, such as capillary electrophoresis coupled to mass spectrometry and microchip technology. It also examines the quantitative aspects of capillary electrophoresis, the possibilities of capillary electrochromatography, and the various chiral columns available. Catalog no. 69330, ISBN: 978-1-4200-6933-4 November 2009, 6-1/8 x 9-1/4, 543 pp. Suggested Price: $174.95 / £111.00 Available in eBook

Catalog no. K11898, ISBN: 978-1-4398-4091-7 February 2011, 6-1/8 x 9-1/4, 488 pp. Suggested Price: $229.95 / £146.00

Encyclopedia of Chromatography

Available in eBook

Edited by

Third Edition Jack Cazes Consultant, Lady Lake, Florida, USA

Advances in Chromatography Volume 48

For more than four decades, scientists and researchers have relied on the Advances in Chromatography Series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. With contributions from an array of international experts, the latest volume captures new developments in this important field that yields great possibilities in a number of applications. The authors’ clear presentation of topics and vivid illustrations make the material in Volume 48 accessible and engaging to biochemists and analytical, organic, polymer, and pharmaceutical chemists at all levels of technical skill.

This guide to specific chromatographic techniques and theory provides a basic introduction to the science and technology of the method, offering key references dealing with the methodology for analysis of specific chemicals and applications in industry. With a focus on emerging technologies and uses, the text contains tables and figures that cogently illustrate and clarify technical points in the articles. The Third Edition provides a valuable, reader-friendly reference for all those who employ chromatographic methods for analysis of complex mixtures of substances, as well as practitioners across the entire spectrum of science. Catalog no. 84593, ISBN: 978-1-4200-8459-7 October 2009, 8-1/2 x 11, 2850 pp. Suggested Price: $690.00 / £439.00 Available in eBook

Catalog no. 84534, ISBN: 978-1-4200-8453-5 December 2009, 6-1/8 x 9-1/4, 422 pp. Suggested Price: $205.95 / £131.00

Handbook of Cryo-Preparation Methods for Electron Microscopy

Available in eBook

Edited by

Annie Cavalier University de Rennes, Cedex, France

Daniele Spehner University of Strasbourg, Illkirch, France

Advances in Chromatography Volume 47 For more than four decades, scientists and researchers have relied upon the Advances in Chromatography series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. Covering the state of the art in separation science, this volume continues to present timely, cuttingedge reviews on chromatography in the fields of bio-, analytical, organic, polymer, and pharmaceutical chemistry. With contributions from leading researchers from around the world, new chapters cover countercurrent chromatography and largescale genotyping as well as cyclic voltammetry detection, a powerful tool for determining the electrochemical characteristics of organic compounds. Catalog no. 60368, ISBN: 978-1-4200-6036-2 February 2009, 6-1/8 x 9-1/4, 462 pp. Suggested Price: $195.95 / £125.00 Available in eBook

Bruno M. Humbel Utrecht University, Netherlands Series: Methods in Visualization

Cryo-electron microscopy has resulted in exciting advances, new hypotheses, and a better understanding of the ultrastructure of living and inert matter. Using an accessible, step-by-step format, this handbook presents the most sophisticated methods used in research laboratories. It describes the basic principles of cryofixation, cryo-ultramicrotomy, embedding at low temperatures and freeze-fracture. The book also explores applications such as electron crystallography, 2D/3D structure analysis, cryo-electron tomography, and techniques for protein localization. Each chapter covers a specific method, including detailed protocols, summary tables, and hundreds of illustrations and diagrams to clarify the techniques. Catalog no. 7227, ISBN: 978-0-8493-7227-8 October 2008, 7 x 10, 704 pp. Suggested Price: $195.95 / £125.00 Available in eBook

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Edited by

R. Andrew Shalliker

Semih Otles Ege University, Izmir, Turkey

Univ. of Western Sydney Chromatographic Science Series

Because the presence and interactions of various compounds in foods during storage and processing impact all aspects of quality, applying proper methods for the analysis of foods is a critical endeavor. During the past century, analytical methods have evolved considerably to include the use of increasingly sophisticated instruments. The Handbook of Food Analysis Instruments focuses on the origin, concept, and use of these instruments. Each chapter presents a specific type of instrument, nuclear magnetic resonance spectroscopy, microwave-assisted process, and more. The operating principles, definitions, theory, and applications to food analysis are examined for every instrument covered in the text.

Widely employed for separating and detecting chemicals in solution, separation techniques are most often applied in tandem, subsequently referred to as hyphenated methods. Hyphenated and Alternative Methods of Detection in Chromatography details the development and application of mass spectral detection techniques coupled with gas phase and liquid phase chromatographies. The book details the advantages and disadvantages of various separation techniques and addresses methods for cutting-edge applications such as proteomics research. This book provides a detailed reference for experienced readers as well as for those who are new to the field of separation and analysis.

Catalog no. 45660, ISBN: 978-1-4200-4566-6 September 2008, 7 x 10, 544 pp. Suggested Price: $185.95 / £119.00

Catalog no. 9077, ISBN: 978-0-8493-9077-7 May 2011, 6 x 9, 330 pp. Suggested Price: $169.95 / £103.00

Available in eBook

Handbook of HPLC Second Edition

Textbook

Edited by

An Introduction to Microscopy

Danilo Corradini and Terry M. Phillips Chromatographic Science Series

Now in its second edition, this updated text examines the new advances made in this field since the publication of the first edition twelve years ago. New concepts presented include monolithic columns, bonded stationary phases, micro-HPLC, two-dimensional comprehensive liquid chromatography, gradient elution mode, retention models for ions, and capillary electromigration techniques. The book also addresses HPLC detectors, LC-MS interfaces, nonlinear chromatography, displacement chromatography of peptides, and proteins, polymer HPLC, fieldflow fractionation, affinity, and ion chromatography. Significant areas of HPLC application are also explored, including chiral pharmaceutical, environmental, food, and forensic analysis. Catalog no. DK3616, ISBN: 978-1-57444-554-1 July 2010, 7 x 10, 715 pp. Suggested Price: $139.95 / £89.00

Suzanne Bell and Keith Morris West Virginia University, Morgantown, Virginia, USA

Microscopy is an invaluable tool in biology and healthcare and increasingly is integrated into modern chemical instrumentation. Written by two forensic experts, this text builds a foundation in the basics of light and polarizing microscopy. The book focuses on forensic science applications and also explores applications in other disciplines. Chapters detail topics ranging from basic theoretical knowledge to advanced subjects such as electron and confocal microscopy and fluorescence. Numerous figures and photographs supplement the text and explain the principles and procedures introduced. Catalog no. 8450X, ISBN: 978-1-4200-8450-4 October 2009, 6-1/8 x 9-1/4, 180 pp. Suggested Price: $71.95 / £45.99

Available in eBook

Handbook of Near-Infrared Analysis Third Edition Edited by

Donald A. Burns NIR Resources, Los Alamos, New Mexico, USA

Emil W. Ciurczak Cadrai Technologies, Goldens Bridge, New York, USA

Presenting nearly 50 percent new and revised material, this edition combines concise theoretical foundations with the latest advances in instrumentation, computerization, calibration, and methods in NIR spectroscopy. Drawing on the experience of more than 60 experts in the field, it underscores accurate as well as time- and cost-effective current trends in sample preparation, calibration transfer, process control, data analysis, and commercial NIR instrumentation. New chapters highlight novel applications in pharmaceuticals, polymers, plastics, petrochemicals, textiles, foods and beverages, baked products, agricultural products, biomedicine, neutraceuticals, and counterfeit detection. Catalog no. 7393, ISBN: 978-0-8493-7393-0 September 2007, 7 x 10, 826 pp. Suggested Price: $229.95 / £146.00

Methods & Instrumentation

Handbook of Food Analysis Instruments

Hyphenated and Alternative Methods of Detection in Chromatography

Ion-Pair Chromatography and Related Techniques Teresa Cecchi Istituto Tecnico Industriale Statale Montani, Fermo, Italy Series: Analytical Chemistry

Providing a thorough exploration of the multiplicity of interactions involved in an IPC system, this book emphasizes the progress from theoretical modeling to application. It explores the practical potential of IPC in the life science, medicine, pharmacology, forensic, food, and environmental sectors. It examines the upgrade of column technology and instrumentation to improve data quality and to increase sample throughput. The book also compares IPC to other instrumental methods of analysis and discusses the rising importance of the ion-pair concept in different analytical techniques. Catalog no. K10075, ISBN: 978-1-4398-0096-6 October 2009, 6-1/8 x 9-1/4, 215 pp. Suggested Price: $133.95 / £85.00 Available in eBook

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Mass Spectrometry of Nucleosides and Nucleic Acids Edited by

Joseph H. Banoub

Methods & Instrumentation / Nanobiotechnology 60

Fisheries and Oceans Canada, Science Branch and Memorial University of Newfoundland, Canada

Patrick A. Limbach

Using Mass Spectrometry for Drug Metabolism Studies Second Edition Edited by

Walter A. Korfmacher

University of Cincinnati, Ohio, USA

Schering-Plough Research Institute, Kenilworth, New Jersey, USA

This volume summarizes and reviews the latest developments in the field of nucleic acid research by mass spectrometry and provides a window on the next generation of analysis. It highlights the most popular ionization methods and illustrates the diverse strategies used in the characterization and sequencing of novel nucleosides and nucleotides. It also covers deoxyribonucleic acid (DNA), DNA-adducts, DNA-drug complexes, ribonucleic acid (RNA) oligomers of biomedical importance, RNA-protein complexes, and post-transcriptional modifications. The contributions presented in this volume capture the range of these advances, helping to inspire new findings and avenues of research.

The first edition of this now classic work helped establish mass spectrometry as the premier tool for drug metabolism studies. Keeping pace with rapid advances, the emergence of new approaches, and increasing demands by vendors, the second edition of this bestseller includes cutting-edge coverage of new instrumentation and software as well as significant new information on the latest findings regarding biomarkers and metabolomics. In addition to exploring all modern techniques and strategies, it offers an excellent overview of the entire drug discovery process, including the latest developments in molecular research.

Catalog no. 44028, ISBN: 978-1-4200-4402-7 December 2009, 7 x 10, 504 pp. Suggested Price: $154.95 / £99.00

Catalog no. 92200, ISBN: 978-1-4200-9220-2 November 2009, 6-1/8 x 9-1/4, 451 pp. Suggested Price: $174.95 / £111.00 Available in eBook

Available in eBook

Mass Spectrometry

Textbook

A Basic Approach

Biomaterials

John Greaves University of California, Irvine, USA

A Nano Approach

John Roboz

Seeram Ramakrishna, Murugan Ramalingam, T.S. Sampath Kumar, and Winston O. Soboyejo

Mount Sinai School of Medicine, New York, USA

Designed specifically for novice users of mass spectronomy, an audience that is not currently well-addressed by existing texts, this book covers the basic concepts, instruments, and techniques with cases illustrating its application in problem solving. Other books in this field focus too narrowly on instrumentation without discussing practical application, or present the information in dense discussions and tables, making the information hard to find. This book does neither, it provides practical advice and key background knowledge in a format that is easy to use. Catalog no. 94181, ISBN: 978-1-4200-9418-3 June 2011, 6-1/8 x 9-1/4, 224 pp., Soft Cover Suggested Price: $69.95 / £44.99 Available in eBook

From a multi-disciplinary point of view, this book examines basic concepts, various processing methodologies, and techniques involved in the preparation and characterization of nanobiomaterials that are specific to biomedical applications. It spans their historical development and reviews their current advances in the field. It describes how basic concepts in nanotechnology are applied to the processing of novel nanobiomaterials, including nanostructured metals and alloys. Presenting illustrative examples and a variety of applications, this text offers a solid framework for understanding present and future trends of biomaterials in human health care systems. Catalog no. 47817, ISBN: 978-1-4200-4781-3 June 2010, 6-1/8 x 9-1/4, 372 pp. Suggested Price: $99.95 / £69.99

Nano- and Biocomposites Edited by

Alan Kin-tak Lau

Two-Dimensional Optical Spectroscopy Minhaeng Cho

University of Southern Queensland, Australia and The Hong Kong Polytechnic University, Kowloon

Farzana Hussain Oregon State University, Corvallis, USA

Khalid Lafdi

Korea University, Seoul, South Korea

University of Dayton, Ohio, USA

Effectively introducing a newly developed research field, this book provides a detailed account of basic theory required for an understanding of two-dimensional vibrational and electronic spectroscopy. It also bridges the gap between the formal development of nonlinear optical spectroscopy and the application of the theory to explain experimental results. The author presents novel definitions and theoretical frameworks for linear and nonlinear response spectroscopy and describes a range of two-dimensional spectroscopic techniques to compare the merits and disadvantages of each technique. He also includes various examples and applications to real molecular and electronic systems. Catalog no. 84291, ISBN: 978-1-4200-8429-0 June 2009, 6-1/8 x 9-1/4, 385 pp. Suggested Price: $144.95 / £92.00

This forward-thinking book is one of the first to meld research in biocomposites with advances in nanocomposite technology to provide an interdisciplinary resource on advanced materials for the biomedical industry. It brings together pioneering researchers who describe their contributions to the field. Among other areas, they cover nanostructured polymer composites and nano/bio composites. They look at developments in tissue engineering, safer resins for tooth and bone repair, and improved artificial joints. They also discuss potential opportunities for continued research in this well-funded field. Catalog no. 8027X, ISBN: 978-1-4200-8027-8 August 2009, 6-1/8 x 9-1/4, 408 pp. Suggested Price: $164.95 / £102.00 Available in eBook

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Textbook

Introduction to Nanoscience and Nanotechnology Gabor L. Hornyak Henry F. Tibbals Joydeep Dutta John J. Moore

Nanofabrication Handbook Edited by

Stefano Cabrini Lawrence Berkeley National Lab, California, USA

Satoshi Kawata

Buy the set and save! Catalog no. 47795, ISBN: 978-1-4200-4779-0 December 2008, 7 x 10, 1574 pp. Suggested Price: $144.95 / £89.00

A comprehensive resource for this rapidly emerging discipline, this book includes detailed discussions of the underlying theoretical basis, the resolution, patterns, and substrates used as well as applications. It builds upon current understanding of microfabrication, moving into the nano dimension and demonstrating how work at this level calls for a different process. Most notably, the book provides guidance on particular lithographic techniques that better fit specific research needs. It includes coverage of how to approach key problems in the decisionmaking process related to materials, methods, surface considerations, and more. Catalog no. 90526, ISBN: 978-1-4200-9052-9 June 2011, 7 x 10, 600 pp. Suggested Price: $129.95 / £82.00 Available in eBook

Also available in individual volumes Textbook

Nanosensors

Introduction to Nanoscience

Theory and Applications in Industry, Healthcare and Defense

Catalog no. 48058, ISBN: 978-1-4200-4805-6 May 2008, 7 x 10, 856 pp. Suggested Price: $89.95 / £41.99

Nanobiotechnology

Osaka University, Japan

A two-part work, the first part elucidates the nanoscale along with the societal impacts of nanoscience, then presents an overview of characterization and fabrication methods. The authors systematically discuss the chemistry, physics, and biology aspects of nanoscience, providing a complete picture of the challenges, opportunities, and inspirations posed by each facet before giving a brief glimpse at nanoscience in action: nanotechnology. The second surveys the field’s broad landscape, exploring the physical basics such as nanorheology, nanofluidics, and nanomechanics as well as industrial concerns such as manufacturing, reliability, and safety.

Edited by

Teik-Cheng Lim SIM University, Singapore

WINNER 2009 CHOICE AWARD OUTSTANDING ACADEMIC TITLE!

Nanosensors, sensing devices with at least one sensing dimension less than 100nm, have become instrumental for monitoring physical and chemical phenomena, detecting biochemicals in cellular organelles, and measuring nanoscopic particles in industrial processes. This book provides a guide to nanosensors. Inspired by his own experience with nanofiber-based gas sensors, the author explains the principles and applications of nanosensors for industry, healthcare, and defense. Each chapter presents an overview of the specific type of nanosensor and then describes the fundamental science that forms the basis of the sensing mechanism, fabrication techniques, and the specific nanosensor’s detection.

Catalog no. 48031, ISBN: 978-1-4200-4803-2 December 2008, 7 x 10, 786 pp. Suggested Price: $89.95 / £41.99

Catalog no. K10373, ISBN: 978-1-4398-0736-1 December 2010, 6-1/8 x 9-1/4, 334 pp. Suggested Price: $119.95 / £76.99

Textbook

Fundamentals of Nanotechnology

Available in eBook

Textbook

Nanobiomaterials Handbook Edited by

Fundamentals and Applications

Balaji Sitharaman

Arlen D. Meyers, Gabor L. Hornyak, Anil K. Rao, and Raechelle A. D’sa

Stony Brook University, New York, USA

A comprehensive overview of and broad introduction to the field of nanobiomaterials, this handbook defines the field and discusses its scope, current status, and future prospects. It then provides an in-depth survey of nanobiomaterials and provides a comprehensive overview of the various synthesis and processing techniques important for developing bionanomaterials. It also includes a detailed overview of the interaction between bionanomaterials/biological systems and the biocompatibility issues associated with bionanomaterials. Extensive references are included at the end of each chapter to enhance additional study. Catalog no. 94661, ISBN: 978-1-4200-9466-4 June 2011, 7 x 10, 808 pp. Suggested Price: $149.95 / £95.00 Available in eBook

Nanotechnology for the Life Sciences

Although touted as the next industrial revolution, the interdisciplinary nature of nanotechnology can pose a challenge to students. Exploring nanotechnology through a life sciences filter, this book focuses on the applications of nanoscience and the engineering aspects of medical and biotechnological nanodevices. Divided into introductory, intermediate, and advanced sections, each chapter offers a succinct introduction, a detailed discussion of the topic at hand with illustrative examples, numerous figures and necessary equations, and a concise summary. Problem sets include exercises of varying difficulty and numerical problems that are analytical to thought provoking. Catalog no. K10561, ISBN: 978-1-4398-1122-1 June 2011, 6-1/8 x 9-1/4, 450 pp. Suggested Price: $139.95 / £89.00

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Nanotech 2010

Nanotechnology in Tissue Engineering and Regenerative Medicine

Nanobiotechnology / General References

Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, Volumes 1-3

Edited by

Ketul Popat

Edited by

NSTI Nanoscience and Technology Inst., Cambridge, Massachusetts, USA

NSTI’s nanotechnology conferences have built a tradition of being the most prestigious forum in the world for leading nano scientists, and Nanotech 2010 is no exception. Top nano scientists offer an up-to-date global perspective on the latest developments in nanotechnology. These volumes cut across every scientific and engineering discipline to provide the most complete record of current accomplishments in Nanotech. Nanotech is available in print, as well as on a DVD that also includes the Cleantech proceedings.

Catalog no. K10090, ISBN: 978-1-4398-0141-3 November 2010, 7 x 10, 302 pp. Suggested Price: $119.95 / £72.00

Buy the set and save!

Available in eBook

Catalog no. N10234, ISBN: 978-1-4398-3418-3 July 2010, 2076 pp., Soft Cover, Suggested Price: $550.00 / £350.00

Cleaning Validation Manual

Also available no DVD!

Catalog no. N10236, ISBN: 978-1-4398-3421-3 June 2010, DVD Suggested Price: $550.00 / £350.00

Also available in individual volumes Fabrication, Particles, Characterization, MEMs, Electronics and Photonics; Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo (Volume 1)

Referred to as “nanomedicine” or “nanobiomedicine,” the application of nanotechnology to medicine can impact diagnosis, monitoring, and treatment of diseases as well as control and understanding of biological systems. Bringing together an unparalleled field of experts, this volume explores various aspects of nanotechnology and its applications in biomedical fields. The book uses an application-oriented approach to relate laboratory-based research to the development of technologies that can be readily adaptable to an industrial environment, focusing chiefly on drug delivery, tissue engineering, and regenerative medicine.

Catalog no. N10231, ISBN: 978-1-4398-3401-5 July 2010, 8-1/2 x 11, 748 pp., Soft Cover Suggested Price: $199.95 / £127.00

A Comprehensive Guide for the Pharmaceutical and Biotechnology Industries Syed Imtiaz Haider and Erfan Syed Asif Julphar Gulf Pharm Industries, United Arab Emirates

With over 20 easy-to-use template protocols for cleaning validation of extensively used equipments, this book provides technical solutions to assist in fulfilling the training needs of finished pharmaceutical manufacturers. The text offers handson training based on current approaches and techniques. The manual is organized as a database to support those involved in the development, manufacturing, auditing, and validation of bio-pharmaceuticals on a pilot scale, that can lead to scaled-up production. It also provides exclusive training guidelines in a CDROM to enable the users to amend or adapt processes as necessary. Catalog no. K11299, ISBN: 978-1-4398-2660-7 May 2010, 7 x 10, 608 pp. Suggested Price: $139.95 / £89.00 Available in eBook

Biofuels, Renewable Energy, Coatings and Compact Modeling; Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo (Volume 3) Catalog no. N10233, ISBN: 978-1-4398-3415-2 July 2010, 6-1/8 x 9-1/4, 742 pp., Soft Cover Suggested Price: $199.95 / £127.00

Life Sciences, Medicine, Diagnostics, Bio Materials and Composites; Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo (Volume 2) Catalog no. N10232, ISBN: 978-1-4398-3402-2 July 2010, 8-1/2 x 11, 636 pp., Soft Cover Suggested Price: $199.95 / £127.00

CRC Handbook of Chemistry and Physics 92nd Edition Edited by

William M. Haynes National Institute of Standards and Technology, Boulder, Colorado, USA

The CRC Handbook of Chemistry and Physics, now in its 92nd edition, continues to be the most accessed and respected scientific reference in the world. Available in its traditional print format, the Handbook is also available as an interactive product on CD-ROM and online. Among a wealth of enhancements, this edition analyzes, updates, and validates molecular formulas and weights, boiling and melting points, densities, and refractive indexes in the Physical Constants of Organic Compounds Table through comparisons with critically evaluated data from the NIST Thermodynamics Research Center. Catalog no. K12569, ISBN: 978-1-4398-5511-9 June 2011, 8-1/2 x 11, 2650 pp. Suggested Price: $149.95 / £95.00 Also available in CD-ROM or online versions

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Using Templates, Project Management, and Six Sigma

Biopharmaceuticals in Plants

Edited by

Toward the Next Century of Medicine

Donnell R. Christian, Jr. and Stephanie Drilling

Kathleen Laura Hefferon

Professional Business Solutions, O’Fallon, Missouri, USA

Cornell Research Foundation, Ithaca, New York, USA

This volume provides templates for the various policies, procedures, and forms that should be contained in the manuals of a laboratory seeking accreditation. It begins with a general introduction and overview of quality assurance and then moves on to cover implementation strategies. It contains best practices and templates for the project management of the design and implementation of the laboratory quality assurance manual and procedures. The book also examines how Six Sigma concepts can be used to optimize laboratories.

Designed as a basic reference for researchers in a wide variety of disciplines, this book discusses plant transformation techniques, the generation of transgenic plants, and the engineering of plant viruses to produce vaccine proteins or peptides. It addresses the basis of mucosal immunity using plant-based oral vaccines, organelle targeting for vaccine production, and the role of glycosylation in plant-made mammalian proteins. It also considers vaccine production in entire crops or in large batch cell suspension cultures as well as the development of clinical trials. The book concludes with a risk analysis and discussion of future applications.

Catalog no. 73044, ISBN: 978-1-4200-7304-1 November 2009, 7 x 10, 1432 pp. Suggested Price: $795.00 / £482.00 Available in eBook

Multiple Testing Problems in Pharmaceutical Statistics Edited by

Alex Dmitrienko Eli Lilly and Company, Indianapolis, Indiana, USA

Ajit C. Tamhane Northwestern University, Evanston, Illinois, USA

Frank Bretz Novartis Pharma AG, Basel, Switzerland

Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical industry, academia, and regulatory agencies, this volume explores multiple comparison research with an emphasis on pharmaceutical applications. It describes important multiplicity problems encountered in pre-clinical and clinical trial settings. The book includes numerous case studies from actual preclinical experiments and clinical trials to help readers quickly learn common multiple testing methods and apply them to real-life problems. It also reviews relevant regulatory guidelines and implements the methods using SAS and R. The data sets and code are available on the book’s website. Catalog no. C9845, ISBN: 978-1-58488-984-7 December 2009, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $89.95 / £57.99 Available in eBook

Catalog no. K10263, ISBN: 978-1-4398-0474-2 November 2009, 6-1/8 x 9-1/4, 224 pp. Suggested Price: $99.95 / £63.99 Available in eBook

Cell Culture Technology for Pharmaceutical and Cell-Based Therapies Edited by

Sadettin Ozturk Centocor Inc., Nottingham, Pennsylvania, USA

Wei-Shou Hu University of Minnesota, Minneapolis, USA

Edited by two of the most distinguished pioneers in genetic manipulation and bioprocess technology, this bestselling reference presents a comprehensive overview of current cell culture technology used in the pharmaceutical industry. Contributions from several leading researchers showcase the importance of gene discovery and genomic technology development in the production of biotechnology products, tissue engineering, and cell-based therapies. Offering detailed guidance, they cover the steps leading up to the creation of viable therapies including host cell selection, cloning and gene amplification, bioreactor design and operation, protein purification, optimization, scale-up, and facility design. Catalog no. DK1481, ISBN: 978-0-8247-5334-4 August 2005, 7 x 10, 776 pp. Suggested Price: $205.95 / £133.00 Available in eBook

Edited by

Advances in Chromatographic Techniques for Therapeutic Drug Monitoring

Renee J. G. Arnold

Edited by

Arnold Consultancy & Technology LLC, New York, USA Series: Drug Discovery Series

Amitava Dasgupta

With emphasis on modeling, methodologies, data sources, and application to realworld dilemmas, this volume introduces the major concepts of pharmacoeconomics and cost-effectiveness analysis (CEA). The book explores the collaboration among the pharmaceutical industry, academia, and government in the development of the human papillomavirus vaccine to demonstrate the full range of ethical and moral issues, as well as public health and commercial concerns involved in decisions entailing CEA. The book provides examples of pharmacoeconomic models used to support the international use of pharmacoeconomics in drug regulation, drug approval, and pricing.

For drugs with a narrow therapeutic index, therapeutic drug monitoring methods are essential for patient management. Although immunoassays are commercially available for many drugs and most laboratories use these assays for routine therapeutic monitoring, they have many limitations which hinder their efficacy. Providing practical guidelines for implementing chromatographic methods, this volume describes the theory and application of therapeutic drug monitoring in clinical laboratories. It addresses preanalytical variables, the pitfalls of immunoassays, tandem mass spectrometry, issues related to pain management and herbal supplements, and drug monitoring for a range of medications.

Catalog no. 84224, ISBN: 978-1-4200-8422-1 October 2009, 6-1/8 x 9-1/4, 264 pp. Suggested Price: $124.95 / £79.99

Catalog no. 67583, ISBN: 978-1-4200-6758-3 October 2009, 7 x 10, 475 pp. Suggested Price: $174.95 / £111.00

Available in eBook

Pharmacoeconomics From Theory to Practice

University of Texas Health Sciences Center at Houston, USA

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General References / Biopharmaceuticals / Drug Delivery

Implementing Quality in Laboratory Policies and Processes

Colloids in Drug Delivery

Drug Delivery / Drug Discovery & Development 64

Edited by

Trans-ungual Drug Delivery

Monzer Fanun

Edited by

Al-Quds University, East Jerusalem, Palestine Series: Surfactant Science

S. Narasimha Murthy

Colloids offer the same advantages of typical materials used for release but can be tailored to specific bulk material properties such as release profiles. Colloidal systems have the potential to increase the shelf life and improve efficacy of a drug, thus reducing the required dosage concentrations and the frequency of administration. Featuring contributions from an international panel of scientists and researchers, this book presents the most recent findings on the application of colloidal properties in drug delivery systems, contributing to the understanding and improved design of novel and advanced drug delivery applications.

Presenting crucial information on the state of the science in trans-ungual drug delivery, this comprehensive overview provides a useful tool to assist in the development of products to treat and solve nail diseases. A growing area of pharmaceutical research, the search for efficient delivery techniques that can cross the nail barrier has yielded several effective strategies. Discussing existing techniques, ongoing research, new approaches, and basic concepts in transungual drug delivery, this book summarizes the current knowledge and represents a jumping-off point for creating novel techniques of drug delivery across the nail.

Catalog no. K10958, ISBN: 978-1-4398-1825-1 March 2010, 7 x 10, 652 pp. Suggested Price: $159.95 / £99.00 Available in eBook

The University of Mississippi, University, USA

Catalog no. K10565, ISBN: 978-1-4398-1129-0 June 2011, 6-1/8 x 9-1/4, 200 pp. Suggested Price: $129.95 / £82.00

Edited by

Approaches to the Conformational Analysis of Biopharmaceuticals

A. Lewis

Roger L. Lundblad

Biocompatibles, UK

Lundblad Biotechnology, Chapel Hill, North Carolina, USA

Drug delivery systems represent a vast area of research and development within biomaterials and medicine and the demand for sophisticated drug delivery devices continues to drive novel product development. This book illustrates how effective drug delivery can be achieved by means other than oral tablets. Written by an international team of experts, this book provides a thorough analysis of the fundamentals, applications, and new technologies of drug-device combination products for use throughout the human body. Topics featured include background information, areas of application, and the development of drug device combination products.

Conformational analysis is becoming more critical in the development of generic biopharmaceuticals. This book describes methods used to establish comparability between potentially identical products. It provides researchers with a critical description of studies drawn from the current literature. The text covers physical methods, such as differential scanning calorimetry, light scanning, and analytical ultracentrifugation, as well as chemical methods, including hydrogen–deuterium exchange and trace labeling. The author shows how these methods support comparability claims for generic biologicals and assure structural integrity of active pharmaceutical ingredients in final drug products.

Catalog no. N10136, ISBN: 978-1-4398-2479-5 January 2010, 6 x 9 Suggested Price: $244.99 / £155.00

Catalog no. K10401, ISBN: 978-1-4398-0780-4 December 2009, 6-1/8 x 9-1/4, 366 pp. Suggested Price: $154.95 / £99.00

Drug Device Combination Products Delivery Technologies and Applications

Available in eBook

Targeted Delivery of Small and Macromolecular Drugs Ajit S. Narang

Dictionary of Marine Natural Products with CD-ROM

Bristol-Myers Squibb, Co., New Brunswick, New Jersey, USA

Edited by

Ram I. Mahato

John W. Blunt and Murray H. G. Munro

University of Tennessee Health Science Center, Memphis, USA

University of Canterbury, Christchurch, New Zealand

Site-specific drug delivery and targeting has attracted much research interest from both academia and industry, but because of the wide array of challenges faced in the development of these systems, only a very few targeted therapies have made it to clinics. Bringing together key research, this volume summarizes current progress with a focus on the novel ideas that are being explored to overcome these challenges. This forward-looking volume includes an in-depth review of various aspects of these drug delivery approaches as well as a detailed discussion of a few case studies in each category.

This dictionary focuses on more than 25,000 marine- natural products. It indexes each by chemical name, organism type, and compound type. Following a similar format to the Chapman & Hall Chemical Database, this comprehensive volume is mirrored on an accompanying CD-ROM that is fully text and structure-searchable. Each entry includes biological source, chemical structure, physical properties, biological activity, and literature references. This new tool offers immediate access to information essential to the development of novel pharmaceuticals, pesticides, and marine anti-fouling agents derived from unique molecular structures of marine natural products.

Edited by

Catalog no. 8772X, ISBN: 978-1-4200-8772-7 May 2010, 7 x 10, 630 pp. Suggested Price: $99.95 / £63.99 Available in eBook

Catalog no. 8216, ISBN: 978-0-8493-8216-1 September 2007, 8-1/2 x 11, 2536 pp. Suggested Price: $629.00 / £401.00 Available in eBook

For more information and a complete list of titles, visit us at www.crcpress.com

Drugs of Natural Origin A Treatise of Pharmacognosy, Sixth Revised Edition Gunnar Samuelsson

Hydrophilic Interaction Liquid Chromatography (HILIC) and Advanced Applications Edited by

Perry G. Wang US FDA, College Park, Maryland, USA

Weixuan He

Uppsala University, Sweden (retired)

This is the first book that comprehensively and systematically describes the new technology of hydrophilic interaction liquid chromatography (HILIC). Hydrophilic interaction chromatography is a separation technique suitable for polar and hydrophilic compounds and orthogonal to reversed phase liquid chromatography. From small organic molecules to proteins, the text explores the many applications of HILIC in the analytical field. Winner of the President’s Award for Excellence, the author explains how HILIC can significantly improve analytical throughput by shortening sample preparation procedure, which is one of the bottlenecks for drug discovery and development in the pharmaceutical industry.

Catalog no. N10257, ISBN: 978-1-4398-3857-0 June 2010, 776 pp. Suggested Price: $149.95 / £95.00

Catalog no. K10384, ISBN: 978-1-4398-0753-8 February 2011, 6-1/8 x 9-1/4, 610 pp. Suggested Price: $169.95 / £108.00 Available in eBook

Handbook of Analytical Validation Ira S. Krull

A Practical Guide to Assay Development and HighThroughput Screening in Drug Discovery

Northeastern University, Boston, Massachusetts, USA

Taosheng Chen

Michael E. Swartz Synomics Pharmaceuticals Svcs LLC, Massachusetts, USA

Memphis, Tennessee, USA Series: Critical Reviews in Combinatorial Chemistry

Written for researchers in the drug and biotechnology industries, this handbook carefully compiles the current regulatory requirements to correctly and properly validate a new or modified analytical method. This authoritative text enables readers to fully and correctly adapt new or modified analytical methods in order to meet regulatory requirements. The book contains the latest regulatory requirements for submitting applications for new drugs or other applications regarding analytical method validation. The chapters apply to small molecules in the conventional pharmaceutical industry as well to biopolymers derived from the biopharmaceutical industry.

Few scientists have the multidisciplinary experience needed to control all aspects of a high-throughput screening (HTS) drug discovery project. This volume integrates the knowledge of experts in biology, chemistry, informatics, instrumentation, automation, technology development, and project management. Enabling researchers in industrial and academic settings to find the most efficient way to carry a project from start to finish, this volume identifies critical targets that are of relevance to drug discovery, discusses the components of the HTS process, and provides step-by-step instructions for an HTS project, while also examining emerging technologies and systems.

Catalog no. DK2235, ISBN: 978-0-8247-0689-0 May 2011, 6-1/8 x 9-1/4, 250 pp. Suggested Price: $169.95 / £108.00

Catalog no. 70509, ISBN: 978-14-2007-050-7 December 2009, 7 x 10, 291 pp. Suggested Price: $164.95 / £102.00

Available in eBook

Human Error in Medicine Second Edition

Quantitative Drug Design

Marilyn Sue Bogner

A Critical Introduction, Second Edition

Institute for the Study of Human Error, Bethesda, Maryland Series: Human Error and Safety

Yvonne Connolly Martin

Medical errors are due most often to the convergence of multiple contributing factors. This new edition of Human Error in Medicine presents an expanded consideration of the topic that emphasizes lessons learned not just in hospitals, but also in home and self-care – important because of the increasing prevalence of chronic illnesses. Bringing together diverse experts, the book covers a wide range of topics including errors in the use of medical equipment, errors from fatigued decision making, latent surgical errors, medical error in the legal system, and error reduction through improved technology and facility design.

Applying quantitative structure-activity relationship (QSAR) techniques at a state-of-the-art level, this book describes how to transform ligand structureactivity relationships into models that predict the potency or activity/inactivity of new molecules. This edition contains a new chapter on methods that identify the 3D conformations to use for 3D QSAR and offers additional discussions on statistical topics, such as partial least squares and kNN potency prediction. Along with re-analyzing old data using newer methods, the expanded case studies explore molecular design based on 3D modeling and include comparisons of ligand- and structure-based models of biological potency.

Catalog no. ER522X, ISBN: 978-0-8058-4522-8 June 2011, 6-1/8 x 9-1/4, 368 pp., Soft Cover Suggested Price: $49.95 / £31.99 Available in eBook

Abbott Laboratories, Abbott Park, Illinois, USA (retired)

Catalog no. 70991, ISBN: 978-1-4200-7099-6 May 2010, 6-1/8 x 9-1/4, 292 pp. Suggested Price: $129.95 / £82.00 Available in eBook

For more information and a complete list of titles, visit us at www.crcpress.com

Drug Discovery & Development

Meda Pharmaceuticals, North Brunswick, New Jersey, USA

This sixth edition provides a multidisciplinary approach for those working in natural product development. It brings together research on the sustainable use of natural products in the development of new drugs, scientifically based herbal remedies, and environmentally adapted biomolecules. Since publication of the 5th edition, new concepts and techniques (genomics, proteomics, and metabolomics) have emerged and herbal remedies have become subject to more rigid legislation aiming to improve their quality and efficacy. This development is reflected in a substantial revision and expansion of the book. This edition also describes many new drugs.

Textbook

Drug Discovery & Development / Pharmaceutical Science 66

Textbook of Drug Design and Discovery Fourth Edition Edited by

Povl Krogsgaard-Larsen, Kristian Stromgaard, and Ulf Madsen The Faculty of Pharmaceutical Sciences, University of Copenhagen, Denmark

Updated and revised, this fourth edition of a bestseller provides current and comprehensive information on all aspects of drug design and discovery. The first part of the book covers general aspects, methods, and principles and the second section covers specific targets and diseases. Topics new to this edition include biostructure- and ligand-based drug design, natural products, imaging, neurotransmitter transporters, opioid and cannabinoid receptors, hypnotics, neglected diseases, and antibiotics. Each chapter includes references for further study. Most chapters also supply background and history needed to provide context, as well as conclusions that summarize the important points. Catalog no. 63227, ISBN: 978-1-4200-6322-6 October 2009, 7 x 10, 476 pp. Suggested Price: $82.95 / £52.99

Three Dimensional QSAR Applications in Pharmacology and Toxicology Jean Pierre Doucet and Annick Panaye University Paris, Francis Series: QSAR in Environmental and Health Sciences

Quantitative structure-activity relationships (QSAR) continue to evolve quickly with an explosion of new tools and techniques. These techniques now play an increasing role in drug design and chemical risk assessment. New molecular descriptors based on three-dimensional structures incorporate a range of classical approaches, including regression and PLS analysis, as well as new nonlinear approaches, such as neural networks and support vector machines. ThreeDimensional QSAR addresses the scope and limitations of different modeling techniques using case studies from pharmacology, toxicology, and ecotoxicology to demonstrate the utility of each technique. Catalog no. 91158, ISBN: 978-1-4200-9115-1 December 2010, 6-1/8 x 9-1/4, 575 pp. Suggested Price: $179.99 / £114.00 Available in eBook

Water-Insoluble Drug Formulation Second Edition

Handbook of Solubility Data for Pharmaceuticals Abolghasem Jouyban Tabriz University, Iran

This time-saving handbook presents a comprehensive database of solubility for pharmaceuticals in organic solvents and binary solvent mixtures. It includes a summary of numerous numerical methods to predict the solubility in mono and mixed solvents and provides the model constants of the Jouyban–Acree model for each solute in binary solvents at various temperatures to predict unmeasured solubilities. The book covers pharmaceutical cosolvents, other organic solvents, and the solubilities of amino acids. User-friendly software to predict the solubility of drugs in mono and mixed solvents is available on the author’s website. Catalog no. K10268, ISBN: 978-1-4398-0485-8 August 2009, 7 x 10, 552 pp. Suggested Price: $257.95 / £164.00 Available in eBook

Quality Assurance and Quality Control in the Analytical Chemical Laboratory A Practical Approach Piotr Konieczka and Jacek Namiesnik Gdansk University of Technology, Poland Series: Analytical Chemistry

Using an approach grounded in hands-on experience, this book provides a strong foundation of the concepts of practical QA/QC. It begins with the theory behind quality control systems and then moves on to discuss examples of tools such as validation parameter measurements. It also examines the use of statistical tests, describes the process of counting the margin of error, and discusses estimating uncertainty. The authors draw on their experience in traceability, statistics, proficiency tests, and method validation to craft a resource that provides practical guidance for each step of the quality assurance process. Catalog no. 82701, ISBN: 978-1-4200-8270-8 February 2009, 6-1/8 x 9-1/4, 232 pp. Suggested Price: $133.95 / £85.00 Available in eBook

Radiopharmaceuticals

Edited by

Introduction to Drug Evaluation and Dose Estimation

Rong Liu

Lawerence E. Williams

AustarPharma, Edison, New Jersey, USA

City of Hope National Medical Center, Duarte, California, USA

Scientists have attributed more than 41 percent of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility The most comprehensive resource on the topic, this second edition brings together a distinguished team of experts to provide step-by-step guidance and scientific background on drug and water properties. Twenty-three chapters systematically describe solubility properties and their impact on formulation, from theory to industrial practice. With detailed discussion on how they contribute to solubilization and dissolution, the text also features three brand new chapters on water-insoluble drugs, exploring regulatory aspects, pharmacokinetic behaviors, and formulation strategies.

This comprehensive overview details the process of radiopharmaceutical development, from cellular studies to animal experiments to the design and implementation of clinical trials. It compares various radiopharmaceuticals and provides guidance on dose estimation and agent selection, covering standard medical internal radiation dose (MIRD), absorbed dose method for imaging agents, vivo methods for obtaining activity data, errors of activity estimation techniques, and phantom-based and patient-based dose estimates. Backed by examples from clinical trials, it discusses two and three dimensional estimation processes, including the use of modern hybrid scanners such as SPECT /CT and PET/CT.

Catalog no. 9644, ISBN: 978-0-8493-9644-1 January 2008, 7 x 10, 688 pp. Suggested Price: $319.95 / £204.00

Catalog no. K10532, ISBN: 978-1-4398-1067-5 December 2010, 6-1/8 x 9-1/4, 326 pp. Suggested Price: $129.95 / £82.00

Available in eBook

Available in eBook For more information and a complete list of titles, visit us at www.crcpress.com

Understanding Drug Actions and Reactions

Dermatokinetics of Therapeutic Agents

Maria A. Hernandez and Appu Rathinavelu

Edited by

Nova Southeastern University, Fort Lauderdale, Florida, USA Plant Engineering Series

S. Narasimha Murthy

Written as an introductory pharmacology text, Basic Pharmacology: Understanding Drug Actions and Reactions provides the in-depth discussion of the chemical and molecular pharmacology fundamentals that pharmacy students require to move on to more advanced study. The book covers the principles of chemistry and biology necessary to understand drug action at the cellular level. It emphasizes the chemical and physical properties of drugs, drug absorption and distribution, drug interactions with cellular receptors, and drug metabolism and interactions. The book effectively explains chemical and molecular pharmacology principles with extensive use of model drug structures.

This book provides an overview of the fundamentals of dermatokinetics: the study of drug uptake into skin layers. It offers a detailed discussion of dermatokinetics that is applicable to any route of administration and to different pharmaceutical drug delivery systems. The author includes a general overview of the theoretical as well as the practical aspects of dermatokinetics and addresses the impact of drug delivery system design on the dermatokinetics of drugs. Chapters cover such topics as dermatopharmacology, cutaneous microdialysis, and dermatokinetics of gene therapeutics.

Basic Pharmacology

Catalog no. TX605, ISBN: 978-1-58716-160-5 February 2006, 6-1/8 x 9-1/4, 392 pp. Suggested Price: $82.95 / £52.99

The University of Mississippi, USA

Catalog no. K10264, ISBN: 978-1-4398-0477-3 April 2011, 6-1/8 x 9-1/4, 248 pp. Suggested Price: $129.95 / £82.00 Available in eBook

Pharmacology

Textbook

Dictionary of Alkaloids

Bioactive Peptides

Second Edition with CD-ROM

Edited by

John Howl and Sarah Jones

John Buckingham, Keith H. Baggaley, Andrew D. Roberts, and Laszlo F. Szabo

University of Wolverhampton, UK

Answering a long-standing need in the pharmaceutical and biotechnology fields, this definitive reference focuses on the biology, pharmacology, and therapeutic applications of endogenous peptide mediators and their analogues. This book takes peptide science beyond chemical synthesis strategies and into the realms of peptide biology and therapeutics. It presents the overall contribution peptide science has made to molecular, cellular, and whole organism biology, while discussing future targets and therapeutic applications. With the mounting worldwide interest in the therapeutic potential of peptides, this is an indispensable work for researchers. Catalog no. 61143, ISBN: 978-1-4200-6114-7 April 2009, 7 x 10, 503 pp. Suggested Price: $185.95 / £119.00

Drawn from the venerable Dictionary of Natural Products, this volume categorizes all known alkaloids to present their concise chemical, structural, and physical data. Doubled in size, this edition includes 20,000 entries. Existing entries have been inspected for accuracy; the vast majority updated. Accompanying the dictionary is a searchable CD-ROM that mirrors the book’s complete contents. The choice of formats allows researchers to conduct high-speed electronic searches, while also giving them the ability to leisurely thumb through the book’s printed pages. With either format, readers will find access to data unparalleled in scope and depth. Catalog no. 77694, ISBN: 978-1-4200-7769-8 January 2010, 8-1/2 x 11, 2374 pp. Suggested Price: $795.00 / £442.00 Available in eBook

Available in eBook

Drug Delivery Systems Third Edition Vasant V. Ranade

Chemistry of Natural Products A Unified Approach, Second Edition N.R. Krishnaswamy

Director of Chemical Research, Academic Pharmaceuticals Inc, Lake Bluff, Illinois, USA

Manifred A. Hollinger Targeted Drug Solutions, Grayslake, Illinois, USA

The second edition of a bestseller, this book discusses the common structural and stereochemical features of naturally occurring organic compounds. It includes a variety of examples to illustrate varied aspects so that the range of structure and behavior exhibited by these compounds is retained within the set framework. The author explores the increasing application of physical (spectroscopic) methods like IR, NMR, CD, ORD, MS, and High Resolution Mass Spectroscopy without undermining the importance of ‘classical’ chemical methods. The section on problem solving helps to develop an analytical and critical evaluation of the data.

The third edition of this popular book contains the latest research and development on drug delivery systems. It also contains a new chapter on nanoscience and technology for drug delivery along with cutting-edge business intelligence and strategies throughout the text. Like previous editions, it continues to provide readers with a multitude of possible drug delivery systems that can be used to improve therapeutics as well as information on the technology involved and the regulatory approaches that make them useful. The authors introduce complex drug delivery technology in an easy-to-understand format with numerous practical examples.

Catalog no. K12250, ISBN: 978-1-4398-4965-1 September 2010, 7 x 10, 432 pp. Suggested Price: $89.95 / £57.99

Catalog no. K10307, ISBN: 978-1-4398-0618-0 April 2011, 6-1/8 x 9-1/4 Suggested Price: $199.95 / £127.00 Available in eBook

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Introduction to Natural Products Chemistry

Basic Pharmacokinetics Edited by

Edited by

Mohsen A. Hedaya

Rensheng Xu, Yang Ye, and Weimin Zhao

Kuwait University, Safat Series: Plant Engineering

Shanghai Institute of Materia Medica, Pudong, China

Pharmacology / Pharmacy

This reference covers basic principles of isolation, structure, characteristics, and the current research techniques of structure elucidation with wet chemistry and spectroscopic analyses. The book includes information on UV, IR, MS and NMR, especially 2d-NMR, HMBC and HMQC, bioactivity, biosynthesis, and chemical synthesis. Written by experts in the field, this volume illustrates how natural products chemistry is one of the most developed scientific fields in China. Topics are illustrated with examples from scientific experiments, making the book attractive to a broad audience, including graduate students and researchers in the field. Catalog no. K12793, ISBN: 978-1-4398-6076-2 April 2011, 7 x 10, 384 pp. Suggested Price: $89.95 / £57.99 Available in eBook

Pharmacokinetic and Pharmacodynamic Data Analysis Concepts and Applications, Fourth Edition Johan Gabrielsson Swedish Pharmaceutical Press, Stockholm

Dan Weiner West Virginia University, Morgantown, USA

This essential professional resource is regarded as the most comprehensive and practical guide to the design, analysis, and interpretation of kinetic and dynamic experiments. It provides the expertise needed to resolve commonly appearing problems with a pedagogic yet accessible approach. For many years a staple in both undergraduate and graduate classrooms , this updated edition adds new case studies to support basic concepts in PK/PD. This edition includes a CD with all exercises and WinNonlin model/ command files.

Textbook

Catalog no. SP5100, ISBN: 978-9-19-765100-4 July 2007, 1250 pp. Suggested Price: $219.95 / £141.00

Textbook

Textbook of Receptor Pharmacology Third Edition Edited by

John C. Foreman and Alasdair J. Gibb University College London, UK

Torben Johansen University of Southern Denmark, Odense

This text presents in-depth coverage of receptor pharmacology. The book combines current understanding of classical quantitative pharmacology and drug-receptor interactions with the basics of receptor structure and signal transduction mechanisms. It focuses on molecular investigation of receptor structure, quantitative functional studies of agonists and antagonists, ligand binding, and signal transduction at the cell membrane. This edition includes updated chapters on receptor structure and signal transduction by G-proteins and tyrosine kinases as well as enhancements to the quantitative treatment of drug-receptor interactions. Several chapters contain problems and worked-out solutions. Catalog no. 52543, ISBN: 978-1-4200-5254-1 September 2010, 7 x 10, 303 pp. Suggested Price: $109.95 / £69.99

This book has been carefully designed for students and others who are new to pharmokinetics. The book explores the use of mathematical models to predict the response of individual patients to drugs. Complementing the material in the text, a CD-ROM is included that contains computer-based presentations with graphics and simulations to allow readers to visualize how a change in one or more pharmacokinetic parameter is reflected in the drug profile of the body. Using a self-instructional format, this text also explores such topics as drug absorption and therapeutic drug monitoring. Catalog no. 46713, ISBN: 978-1-4200-4671-7 April 2007, 6-1/8 x 9-1/4, 328 pp. Suggested Price: $88.95 / £56.99

Drug Delivery and Targeting For Pharmacists and Pharmaceutical Scientists Edited by

Anya M. Hilary Saint Louis University, Madrid, Spain

Andrew W. Lloyd University of Brighton, United Kingdom

James Swarbrick PharmaceuTech, Inc, Pinehurst, North Carolina, USA

An accessible and easy-to-read text, this is the first book to provide a comprehensive introduction to the principles of advanced drug delivery and targeting, their current applications, and potential future developments, making it indispensable for pharmaceutical students, scientists, and researchers. It covers how to optimize therapeutic efficacy; drug absorption, unwanted distribution, and premature inactivation / elimination; attempts to minimize toxicity or alter immunogenicity; achieving rate-controlled drug release and effective drug targeting; routes of delivery; and technologies such as biosensors, microchips, stimuli-sensitive hydrogels, and plasmid-based gene therapy. Catalog no. TF1359, ISBN: 978-0-415-27198-1 September 2001, 7 x 10, 496 pp., Soft Cover Suggested Price: $95.95 / £60.99

Textbook

Essentials of Law and Ethics for Pharmacy Technicians Third Edition Kenneth M. Strandberg North Dakota State University, Fargo, USA Plant Engineering Series

Fully revised to address the latest procedural, ethical, and technological developments in this rapidly changing field, this third edition of a bestseller employs a chapter by chapter edit for clarity alongside a wealth of new material, including a new appendix on the legal standing of electronic transmission of prescriptions. It covers the latest in state and federal regulations pertaining to the administration of new medications, including birth control and the morning after pill, as well as new regulations on Over the Counter label claims. Catalog no. K12451, ISBN: 978-1-4398-5315-3 May 2011, 6-1/8 x 9-1/4, 256 pp. Suggested Price: $52.95 / £33.99

For more information and a complete list of titles, visit us at www.crcpress.com

Pharmaceutical Dosage Forms and Drug Delivery

Understanding Medical Terms

Ram I. Mahato

Walter F. Stanaszek, Mary J. Stanaszek, Robert J. Holt, and Steven Strauss

Integrating aspects of physical pharmacy, biopharmaceuticals, drug delivery, and biotechnology, Pharmaceutical Dosage Forms and Drug Delivery presents basic physico-chemical principles and their application in the design of dosage forms. This book addresses the relevance of these principles to the biopharmaceutical aspects of drugs. It explores the latest developments in the application of biomaterials, including polymers and biotechnology-based agents, to the development of novel dosage forms. In addition, the book discusses physico-chemical parameters used for the design, development, and evaluation of biotechnological dosage forms. This text also provides review questions and answers for students. Catalog no. 9285, ISBN: 978-0-8493-9285-6 June 2007, 6-1/8 x 9-1/4, 336 pp. Suggested Price: $88.95 / £56.99

Pharmacy Education Series

This book provides an updated orientation to the prefixes, suffixes, and roots used to determine most medical terms encountered in practice. The book covers the basics of medical terminology and therapeutic terminology, thoroughly explains medical terms, and contains a complete index for quick reference, a table of common abbreviations for each therapeutic chapter, and expanded tables that put the information at readers fingertips. An invaluable reference for pharmacists, technicians, health care providers, pharmacy students, and anyone who requires a working knowledge of medical terminology, this edition is even more complete for today’s practitioner. Catalog no. TX65951, ISBN: 978-1-56676-595-4 July 1998, 7 x 10, 436 pp. Suggested Price: $73.95 / £46.99

Textbook

Algorithms in Bioinformatics

Pharmacy Fits

A Practical Introduction

Practical Tactics for Integrating Medication Related Computer Systems, Teams and Processes Faron Moore

Wing-Kin Sung National University of Singapore Series: Chapman & Hall/CRC Mathematical & Computational Biology

Many of the challenges for healthcare IT projects can be traced to confusing data related to medication processes. This text offers valuable insight into how these challenges might be addressed, both in pharmacy informatics and in the broader health IT arena. This book is easy and enjoyable to read, practical, and insightful into the source of challenges in an attempt to both aid and popularize pharmacy informatics. The book brings a fresh perspective on how healthcare IT project problems are faced and solved. A glossary and worksheets are provided to boost comprehension.

This classroom-tested text provides an in-depth introduction to the algorithmic techniques applied in bioinformatics. For each topic, the author clearly details the biological motivation, precisely defines the corresponding computational problems, and includes detailed examples to illustrate each algorithm. The text covers basic molecular biology concepts, sequence similarity, the suffix tree, sequence databases, sequence and genome alignment, the phylogenetic tree, genome rearrangement, motif finding, the secondary structure of RNA, peptide sequencing, and population genetics. Supplementary material is provided on the author’s website and a solutions manual is available for qualifying instructors.

Catalog no. K11929, ISBN: 978-1-4398-4148-8 June 2011, 7 x 10, 200 pp., Soft Cover Suggested Price: $69.95 / £44.99

Catalog no. C7033, ISBN: 978-1-4200-7033-0 November 2009, 6-1/8 x 9-1/4, 407 pp. Suggested Price: $82.95 / £41.99

Available in eBook

Bayesian Modeling in Bioinformatics Edited by

Textbook

Dipak K. Dey

Pharmacy

University of Connecticut, Storrs, USA

What It Is and How It Works, Third Edition

Samiran Ghosh

William N. Kelly

Weill Cornell Medical College, White Plains, New York, USA

William N. Kelly Consulting Inc., Oldsmar, Florida, USA Series: Plant Engineering

Bani K. Mallick Texas A&M University, College Station, USA

Developments since the first edition include the new Medicare prescription benefit, a growing emphasis on medication safety, and the dynamic technology driving safety in organized health care settings. This second edition explores all of these changes that have affected the field of pharmacy in recent years. Expanding coverage throughout, the text features a new chapter on the role of the pharmacist in today’s health care delivery system, as well as new material on support personnel, the consolidation of ambulatory pharmacy, and current controversies within the pharmaceutical industry.

This volume discusses the development and application of Bayesian statistical methods for the analysis of high-throughput bioinformatics data arising from problems in molecular and structural biology and disease-related medical research such as cancer. It presents a broad overview of statistical inference, clustering, and classification problems in two main high-throughput platforms: microarray gene expression and phylogenic analysis. Illustrating concepts using real-world data, the book covers a variety of recently developed Bayesian techniques, along with applications in genome-wide studies, phylogenetics, breast cancer, expression genomics, and more.

Catalog no. 7246, ISBN: 978-0-8493-7246-9 December 2006, 6-1/8 x 9-1/4, 512 pp. Suggested Price: $57.95 / £36.99

Pharmacy / Bioinformatics

University of Tennessee Health Science Center, Memphis, USA Plant Engineering Series

A Guide for Pharmacy Practice, Second Edition

Catalog no. C7017, ISBN: 978-1-4200-7017-0 September 2010, 6-1/8 x 9-1/4, 466 pp. Suggested Price: $89.95 / £57.99 Available in eBook

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Bioinformatics Database Systems Jason T.L. Wang

BioMEMS

New Jersey Institute of Technology, Newark, USA

Science and Engineering Perspectives

Katherine G. Herbert

Simona Badilescu and Muthukumaran Packirisamy

Bioinformatics

University of Montclair, New Jersey, USA

Concordia University, Montreal, Canada

This book explains the world of database systems to bioinformatics and cheminformatics database users. It begins with a survey of popular databases, including primary genetic and protein sequence, phylogenetic, structure and pathway, and microarray databases. The text discusses information management and modeling issues in these databases, addressing data quality issues as well as efforts in the data cleaning field to combat such problems. From drug discovery to the structure of various molecular components of the cell, the authors present new applications and case studies illustrating concepts in database systems.

Written to cover often overlooked areas in the field of bioMEMS, this volume bridges topics related to biomolecules and complex biological entities with those directly related to the design, fabrication, and characterization of the devices. Unlike other references, this text aids with the fundamental physiochemical understanding of biological processes relevant to the performance of various biosensing devices. Accessible to seniors and graduate students enrolled in engineering programs, the book includes problems in each chapter as well as case studies to provide real-life examples.

Catalog no. K10630, ISBN: 978-1-4398-1247-1 May 2011, 6-1/8 x 9-1/4, 300 pp. Suggested Price: $79.95 / £49.99

Catalog no. K10877, ISBN: 978-1-4398-1699-8 April 2011, 7 x 10, 400 pp. Suggested Price: $99.95 / £63.99

Available in eBook

Bioinformatics High Performance Parallel Computer Architectures

Cancer Systems Biology

Edited by

Edwin Wang

Bertil Schmidt

National Research Council of Canada and McGill University Center for Bioinformatics, Montreal, Quebec Series: Chapman & Hall/CRC Mathematical & Computational Biology

Nanyang Technological University, Singapore Series: Embedded Multi-Core Systems

Textbook

Edited by

Written by internationally renowned experts, this book introduces emerging parallel architectures, their corresponding programming paradigms, and their bioinformatics applications. Providing two introductory chapters to supply necessary background on sequential bioinformatics algorithms and parallel architectures—such as multi-cores, Cell B.E., GPUs, FPGAs—it then presents parallelization strategies and performance evaluations for numerous state-ofthe-art bioinformatics algorithms and tools. Topics include pairwise sequence alignment, multiple sequence alignment, BLAST, motif finding, and pattern matching. The book also covers sequence assembly, hidden Markov models, molecular dynamics, and evolutionary tree reconstruction.

The unprecedented amount of data produced with high-throughput experimentation forces biologists to employ mathematical representation and computation to glean meaningful information in systems-level biology. Applying this approach to the underlying molecular mechanisms of tumorigenesis, cancer research is enjoying a series of new discoveries and biological insights. Unique in its dualistic approach, this book introduces the concepts and theories of systems biology and the applications of systems biology in cancer research. It presents basic cancer biology and cutting-edge topics of cancer research for computational biologists alongside systems biology analysis tools for experimental biologists.

Catalog no. K10768, ISBN: 978-1-4398-1488-8 July 2010, 6-1/8 x 9-1/4, 370 pp. Suggested Price: $129.95 / £82.00

Catalog no. K10596, ISBN: 978-1-4398-1185-6 May 2010, 7 x 10, 455 pp. Suggested Price: $89.95 / £57.99

Available in eBook

Biological Sequence Analysis Using the SeqAn C++ Library Institut fur Informatik, Berlin, Germany

Combinatorial Pattern Matching Algorithms in Computational Biology Using Perl and R

Knut Reinert

Gabriel Valiente

Freie Universität Berlin, Germany Series: Chapman & Hall/CRC Mathematical & Computational Biology

Technical University of Catalonia, Barcelona, Spain Series: Chapman & Hall/CRC Mathematical & Computational Biology, 22

Written by the founders of the SeqAn project, this book first describes the general library design of SeqAn. It introduces biological sequence analysis problems, discusses the benefit of using software libraries, summarizes the design principles and goals of SeqAn, details the main programming techniques used in SeqAn, and demonstrates the application of these techniques in various examples. Focusing on the components provided by SeqAn, the second part explores basic functionality, sequence data structures, alignments, pattern and motif searching, string indices, and graphs. The last part describes applications of SeqAn to genome alignment, consensus sequence, suffix array construction, and more.

Emphasizing the search for patterns within and between biological sequences, trees, and graphs, this book shows how combinatorial pattern matching algorithms can solve computational biology problems that arise in the analysis of genomic, transcriptomic, proteomic, metabolomic, and interactomic data. It provides an intuitive presentation of the algorithms, followed by a detailed exposition in pseudo-code. The author offers alternative implementations of the algorithms in Perl and R to enable the testing of algorithms and the building of projects based on the code. Perl and R source code for all algorithms are on the authors’ website.

Catalog no. C7623, ISBN: 978-1-4200-7623-3 November 2009, 6-1/8 x 9-1/4, 329 pp. Suggested Price: $92.95 / £58.99

Catalog no. C6973, ISBN: 978-1-4200-6973-0 April 2009, 6-1/8 x 9-1/4, 368 pp. Suggested Price: $92.95 / £58.99

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Andreas Gogol-Döring

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Data Mining in Biomedical Imaging, Signaling, and Systems Sumeet Dua Louisiana Tech University, Ruston, USA

Genetics and Randomness

Rajendra Acharya U

Anatoly Ruvinsky

Ngee Ann Polytechnic, Singapore

University of New England, Australia

Approaching the techniques and challenges of image mining from a multidisciplinary perspective, this book presents data mining techniques, methodologies, algorithms, and strategies to analyze biomedical signals and images. Written by experts, the text addresses data mining paradigms for the development of biomedical systems. It also includes special coverage of knowledge discovery in mammograms and emphasizes both the diagnostic and therapeutic fields of eye imaging.

It is important to realize the underlying limitations of scientific prediction in genetics. Avoiding unnecessary technical details, this book helps readers accept and embrace a probabilistic view and understand the role of randomness in critical biological processes. It explores the nature of genetic uncertainty from different points of view and at different levels of biological organization. The book also traces the origin of some ideas of randomness starting from the basics of quantum mechanics and molecular genetics to modern evolutionary genetics and the philosophy of mathematics.

Catalog no. K11798, ISBN: 978-1-4398-3938-6 May 2011, 6-1/8 x 9-1/4, 448 pp. Suggested Price: $109.95 / £66.99 Available in eBook

Catalog no. 78852, ISBN: 978-1-4200-7885-5 July 2009, 6-1/8 x 9-1/4, 160 pp., Soft Cover Suggested Price: $82.95 / £52.99 Available in eBook

Feedback Control in Systems Biology

Glycome Informatics

Edited by

Kiyoko F. Aoki-Kinoshita

Carlo Cosentino

Soka University, Hachioji, Tokyo, Japan Series: Chapman & Hall/CRC Mathematical & Computational Biology

University of Catanzaro, Catanzaro, Italy

Declan Bates

Bioinformatics

Edited by

Methods and Applications

University of Leicester, Leicester, UK

This self-contained, easy-to-follow book demonstrates how feedback control concepts can be applied to systems biology. Each chapter introduces a field within control engineering and then provides several applications in cellular biology. Chapters focus on the essential ideas and concepts from control theory that have found applicability in the systems biology research literature, including basic linear introductory material as well as more advanced nonlinear techniques. The book illustrates key ideas and concepts with examples from cellular biology. It also includes research literature, illustrations, and references to enhance study. Catalog no. K10870, ISBN: 978-1-4398-1690-5 June 2011, 6-1/8 x 9-1/4, 300 pp. Suggested Price: $89.95 / £57.99 Available in eBook

Glycome Informatics covers all known informatics methods pertaining to the study of glycans, which provide crucial functional roles in many biological processes. The book supplies all the necessary background information, including glycan classes, motifs, and nomenclature. It offers a complete list of relevant databases and resources on glycobiology and presents a wide range of methods, from computer theory and data mining to glycomics. The author also discusses key points and ideas for potential research projects. Sequence analysis and machine learning methods as well as glycomic technologies are described in the appendices. Catalog no. C8334, ISBN: 978-1-4200-8334-7 November 2009, 6-1/8 x 9-1/4, 256 pp. Suggested Price: $92.95 / £58.99 Available in eBook

Gene Expression Studies Using Affymetrix Microarrays

Handbook of Chemoinformatics Algorithms Jean-Loup Faulon University of Evry, France

Hinrich Gohlmann and Willem Talloen

Andreas Bender

Johnson & Johnson, Beerse, Belgium Series: Chapman & Hall/CRC Mathematical & Computational Biology

Leiden University, The Netherlands Series: Chapman & Hall/CRC Mathematical & Computational Biology

The Affymetrix GeneChip® system is one of the most widely adapted microarray platforms. However, due to the preponderance of information available, many researchers compromise their findings by never going beyond the system’s default settings. This truly multidisciplinary work eliminates confusion, explaining the entire process of a gene expression study from conception to conclusion. Offering valuable instruction and insight for both the novice and experienced researcher, the authors show how to optimize experiments and data analysis using Affymetrix as well as other microarray platforms, and explain various analysis methods via illustrative examples using R and BioConductor.

This handbook provides an overview of the most common chemoinformatics algorithms in a single source. It explains how algorithms and graph theory are applied to chemical problems, such as structure–activity/property predictions. The book describes virtual screening techniques, docking methods, inverseQSAR methods, de novo design algorithms, sequence alignment algorithms, and classical machine learning algorithms. Along with reviewing open source software and databases, it also explores the development and validation of QSAR models and covers applications in combinatorial library design, synthesis design, biological network inference, and systems biology.

Catalog no. C6515, ISBN: 978-1-4200-6515-2 July 2009, 6-1/8 x 9-1/4, 359 pp. Suggested Price: $89.95 / £57.99

Catalog no. C2922, ISBN: 978-1-4200-8292-0 April 2010, 6-1/8 x 9-1/4, 454 pp. Suggested Price: $99.95 / £63.99

Available in eBook

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Handbook of Fitting Statistical Distributions with R Zaven A. Karian Denison University, Granville, Ohio, USA

Edward J. Dudewicz Syracuse University, New York, USA

Bioinformatics

Along with in-depth coverage of cutting-edge applications and contributions from experts who offer deep insight on a range of topics, this comprehensive and authoritative handbook presents the latest and best methods, algorithms, and computations for fitting distributions to data. The book covers GLD methodology and fitting systems as well as recent additions to GLD and generalized bootstrap methods. It also explores real-world applications in agriculture, reliability estimation, hurricanes/typhoons/cyclones, hail storms, water systems, insurance and inventory management, and materials science. The accompanying CD-ROM includes the R programs used for many of the computations. Catalog no. C7117, ISBN: 978-1-58488-711-9 October 2010, 7 x 10, 1718 pp. Suggested Price: $149.95 / £95.00

Methods in Medical Informatics Fundamentals of Healthcare Programming in Perl, Python, and Ruby Jules J. Berman Columbia, Maryland, USA Series: Chapman & Hall/CRC Mathematical & Computational Biology

A user friendly, step-by-step practical guide for applying basic informatics algorithms to medical data sets, this book includes examples using Perl, Python, and Ruby. The author employs a minimal selection of commands for quick learning, and references only free, publicly available resources. This book demonstrates how easy it is to master the wide variety of data types encountered in a healthcare setting with just a few simple programming commands. It covers building blocks, medical data resources, primary tasks of medical informatics, and medical discovery. Catalog no. K11946, ISBN: 978-1-4398-4182-2 September 2010, 7 x 10, 413 pp. Suggested Price: $79.95 / £49.99 Available in eBook

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Microarray Innovations Introduction to Bio-Ontologies

Technology and Experimentation

Peter N. Robinson and Sebastian Bauer

Edited by

Charite Universitatsmedizin Berlin, Germany Series: Chapman & Hall/CRC Mathematical & Computational Biology

Gary Hardiman University of California at San Diego, La Jolla, USA Series: Drug Discovery Series

Ontologies have become the tool of choice for organizing and describing the meaning of biological and medical data. This book introduces the most important aspects of bio-ontologies, including statistical overrepresentation analysis, semantic similarity, and inference. Each chapter reviews the main goals of the methods discussed, explains the mathematical and computation methods used to achieve those goals, offers practical examples, and includes theoretical and practical exercises. A supporting website provides ontologies and files for the practical exercises and open-source software.

Microarray technologies and applications have evolved steadily with increasing content and better analytical methodologies. This compendium represents a cross section of the past five years of microarray methods and applications and their usage in drug discovery and biomedical research. Expert contributors cover improvements in automation, new substrates for printing arrays, platform comparisons and contrasts, experimental design, data normalization and mining schemes, and epigenomic array studies. It also reviews electronic microarrays, comparative genomic hybridization, microRNA arrays, mutational analyses, clinical diagnostic arrays, protein arrays, and neuroscience applications.

Catalog no. K11656, ISBN: 978-1-4398-3665-1 May 2011, 6-1/8 x 9-1/4, 306 pp. Suggested Price: $79.95 / £49.99 Available in eBook

Catalog no. 94483, ISBN: 978-1-4200-9448-0 April 2009, 7 x 10, 314 pp. Suggested Price: $133.95 / £85.00

Meta-analysis and Combining Information in Genetics and Genomics

Available in eBook

Rudy Guerra

Volume 3 Advanced Genomics

Rice University, Houston, Texas, USA

Darlene R. Goldstein

Principles and Practices of Plant Genomics

EPFL SB IMA STAT, Switzerland Series: Chapman & Hall/CRC Mathematical & Computational Biology

Edited by

This book provides many novel techniques for analyzing data from modern biological studies that involve multiple data sets. It addresses the combination of similar data types: genotype data from genome-wide linkage scans and data derived from microarray gene expression experiments. The expert contributors show how some data combination problems can arise even within the same basic framework and offer solutions to these problems. They also discuss the combined analysis of different data types, giving readers an opportunity to see data combination approaches in action across a wide variety of genome-scale investigations.

This book presents the basic and applied aspects of sequencing of genes and genomes and their implication in the fine-scale elucidation of the plant genomes. The third volume presents an overview on the advances of plant genomics made in the past century; deliberations on the genomics resources; and concepts, tools, strategies, and achievements of comparative, evolutionary, and functional genomics and whole-genome sequencing. It also presents critical reviews on the already completed genome initiatives and glimpses on the currently progressing genome initiatives.

Catalog no. C522X, ISBN: 978-1-58488-522-1 July 2009, 6-1/8 x 9-1/4, 360 pp. Suggested Price: $99.95 / £63.99

Chittaranjan Kole and Albert G. Abbott Clemson University, South Carolina, USA

Catalog no. N10281, ISBN: 978-1-57808-683-2 August 2010, 6-1/8 x 9-1/4, 370 pp. Suggested Price: $119.95 / £76.99 Available in eBook

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Statistics for Biological Networks How to Infer Networks from Data Ernst Wit Sebastian Bassi Universidad Nacional de Quilmes, Bernal, Argentina Series: Chapman & Hall/CRC Mathematical & Computational Biology

University of Groningen, The Netherlands

Veronica Vinciotti Brunel University, Middlesex, UK

Vilda Purutcuoglu Middle East Technical University, Ankara, Turkey Series: Chapman & Hall/CRC Interdisciplinary Statistics

This book helps scientists solve their biological problems by helping them understand the basics of programming. Requiring no prior knowledge of programming-related concepts, it focuses on the easy-to-use, yet powerful, Python computer language. After introducing Python and the Biopython package, the book covers advanced topics, such as XML. It contains working code that solves real-world biological problems and includes a DVD with a readyto-run virtual machine (VM) based in DNALinux to test the code. Along with other material, the appendices offer installation instructions for the VM, Python, and Biopython.

An introduction to a new paradigm in social, technological, and scientific discourse, this book presents an overview of statistical methods for describing, modeling, and inferring biological networks using genomic and other types of data. It covers a large variety of modern statistical techniques, such as sparse graphical models, state space models, Boolean networks, and hidden Markov models. The authors address gene transcription data, microRNAs, ChIP-chip, and RNAi data. Along with end-of-chapter exercises, the text includes many realworld examples with implementations using a dedicated R package.

Catalog no. C9292, ISBN: 978-1-58488-929-8 September 2009, 6-1/8 x 9-1/4, 587 pp., Soft Cover Suggested Price: $71.95 / £45.99

Catalog no. K11928, ISBN: 978-1-4398-4147-1 June 2011, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $79.95 / £49.99

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Textbook

Bioinformatics

Python for Bioinformatics

Statistics in Human Genetics and Molecular Biology

R Programming for Bioinformatics

Cavan Reilly

Robert Gentleman Series: Chapman & Hall/CRC Computer Science & Data Analysis

University of Minnesota, Minneapolis, USA Series: Chapman & Hall/CRC Texts in Statistical Science

This practical guide focuses on the programming skills needed to use R for the solution of bioinformatics and computational biology problems. It covers the fundamentals of the R language, object-oriented programming in R, and data mark-up and web services languages and tools. The author also examines different aspects of string handling and manipulations; discusses the interfacing of R with other languages, such as C, FORTRAN, Perl, and Python; and explains how to write software packages as well as debug and profile R code. The complete source code is available on the book’s website.

This book provides a basic understanding of problems arising in the analysis of genetics and genomics. With many worked examples and end-of-chapter exercises, it presents statistical applications in genetic mapping, DNA/protein sequence alignment, and analyses of gene expression data from microarray experiments. The text covers basic molecular biology, likelihood-based statistics, physical mapping, markers, linkage analysis, parametric and nonparametric linkage, sequence alignment, feature recognition, hidden Markov models, and Bayesian approaches. It also discusses differential gene expression detection as well as classification and cluster analysis using gene expression data sets.

Catalog no. C6367, ISBN: 978-1-4200-6367-7 July 2008, 6-1/8 x 9-1/4, 328 pp. Suggested Price: $75.95 / £47.99 Available in eBook

Randomization, Bootstrap and Monte Carlo Methods in Biology Third Edition

Catalog no. C7263, ISBN: 978-1-4200-7263-1 June 2009, 6-1/8 x 9-1/4, 280 pp. Suggested Price: $61.95 / £39.99

Statistics of Medical Imaging Tianhu Lei

Western EcoSystem Technology, Inc., Laramie, Wyoming, USA

University of Pennsylvania & Children’s Hospital, Philadelphia, USA Series: Chapman & Hall/CRC Interdisciplinary Statistics

This new edition of the bestselling Randomization, Bootstrap and Monte Carlo Methods in Biology illustrates the value of a number of these methods with an emphasis on biological applications. It has been updated to reflect developments in methodology, computing, and applications and features extensively revised chapters on bootstrap and Monte Carlo methods that incorporate many new applications. The author also includes new information on time series and multivariate, survival, and growth data and provides an expanded appendix on software for computational statistics.

This book covers the extensive work being done in the statistical aspects of medical imaging. It presents a complete look at medical imaging and statistics, from the statistical aspects of imaging technology to the statistical analysis of images. It provides technicians and students with the statistical principles that underlay medical imaging and offers reference material for researchers involved in the design of new technology. Illustrations are included throughout as are many real examples and algorithms. The text also includes exercises developed out of the author’s many years of experience.

Catalog no. C5416, ISBN: 978-1-58488-541-2 August 2006, 6-1/8 x 9-1/4, 480 pp. Suggested Price: $89.95 / £56.99

Catalog no. C8842, ISBN: 978-1-4200-8842-7 June 2011, 6-1/8 x 9-1/4, 416 pp. Suggested Price: $99.95 / £63.99

Bryan F.J. Manly

Available in eBook

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Stochastic Modelling for Systems Biology Darren J. Wilkinson School of Mathematics and Statistics, Newcastle University, UK Series: Chapman & Hall/CRC Mathematical & Computational Biology

Bioinformatics / Biostatistics

Stochastic kinetic models are increasingly accepted as the best way to represent and simulate genetic and biochemical networks. Stochastic Modelling for Systems Biology provides an accessible introduction to this theory using examples that are familiar to systems biology researchers. Focusing on computer simulation, the author examines the use of stochastic processes for modelling biological systems. Along with the latest simulation techniques and research material, such as parameter inference, the text includes many examples and figures as well as software code in R for various applications. Catalog no. C5408, ISBN: 978-1-58488-540-5 April 2006, 6-1/8 x 9-1/4, 280 pp. Suggested Price: $95.95 / £60.99

Textbook

Systems Biology and Bioinformatics: A Computational Approach Kayvan Najarian Virginia Commonwealth University, Richmond, USA

Siamak Najarian and Shahriar Gharibzadeh Amirkabir University of Technology, Tehran, Iran

Christopher N. Eichelberger University of North Carolina, Charlotte, USA

Emphasizing computational methods, Systems Biology and Bioinformatics provides an introduction to system biology and its impact on biology and medicine. The book reviews the basic principles of molecular and cell biology using a system-oriented approach, with a brief description of the high-throughput biological experiments that produce databases. The methods presented in the text include techniques to discover genes, perform nucleotide and amino acid sequence matching, and estimate static gene dynamic pathways. The book also explains how to use system-oriented models to predict the behavior of biological systems for important applications such as rational drug design. Catalog no. 46500, ISBN: 978-1-4200-4650-2 April 2009, 6-1/8 x 9-1/4, 190 pp. Suggested Price: $71.95 / £45.99

Accuracy and Reliability of Statistical Classification Advanced ROC Analysis

Analysis of Questionnaire Data with R Bruno Falissard INSERM U669, Paris, France

Addressing the problem of inefficient collection and analysis of questionnaire data, this book proposes a methodology that uses R software. The author takes a practical approach to the subject, presenting principles first followed by detailed examples of their application to real data. He discusses principles of good questionnaire design, data management, capture, and manipulation and covers descriptive statistics, scoring, reliability, and missing data. The book focuses on readily available R packages and integrates discussion of their implementation and code throughout. All the data sets and R code packages are provided on a website. Catalog no. K10917, ISBN: 978-1-4398-1766-7 June 2011, 6-1/8 x 9-1/4, 300 pp. Suggested Price: $89.95 / £57.99 Available in eBook

Textbook

Applied Categorical and Count Data Analysis Wan Tang, Hua He, and Xin M. Tu University of Rochester, Rochester, New York, USA Series: Chapman & Hall/CRC Texts in Statistical Science

In addition to traditional topics like logistic and Poisson regression models, this book covers modern statistical analysis subjects, such as models for count variables, longitudinal data analysis, reliability analysis, and methods for dealing with missing values. It pays special attention to small samples by including exact methods for inference where possible. The authors analyze dependent outcomes from clustered and longitudinal study designs using the generalized linear mixedeffects model and weighted generalized estimating equations. They also include SAS, SPSS, and R codes for implementation of the methods discussed. Catalog no. K10311, ISBN: 978-1-4398-0624-1 June 2011, 6-1/8 x 9-1/4, 360 pp. Suggested Price: $89.95 / £57.99

Artificial Neural Networks in Biological and Environmental Analysis Grady Hanrahan

Kelly H. Zou, Aiyi Liu, Andriy Bandos, Howard Rockette, and Lucila Ohno-Machado

California Lutheran University, Los Angeles, USA Series: Analytical Chemistry

This book gives a historical overview of the empirical and nonparametric ROC method for continuous diagnostic and classification data. It introduces methods for estimating and comparing ROC curves based on diagnostic test results and covers both semiparametric and parametric models. The authors develop likelihood-based algorithms for estimating an ROC curve and its characteristics under these models. They also present methods for sample size calculations and Monte Carlo simulations. The text includes many real clinical examples, with R code provided for all of them.

Based on our knowledge of the functioning human brain, ANNs (artificial neural networks) serve as a modern paradigm for computing. Drawing on the experience and knowledge of a practicing professional, this book provides a comprehensive introduction and practical guide to the development, optimization, and application of ANNs in modern environmental and biological analysis. Presenting basic principles together with simulated biological and environmental data sets and real applications in the field, this volume helps scientists comprehend the power of the ANN model to explain physical concepts and to demonstrate complex natural processes.

Catalog no. K10617, ISBN: 978-1-4398-1222-8 June 2011, 6-1/8 x 9-1/4, 300 pp. Suggested Price: $89.95 / £57.99 Available in eBook

Catalog no. K10638, ISBN: 978-1-4398-1258-7 January 2011, 6-1/8 x 9-1/4, 200 pp. Suggested Price: $89.95 / £57.99 Available in eBook

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Basic Statistics and Pharmaceutical Statistical Applications

Bayesian Disease Mapping

Second Edition

Hierarchical Modeling in Spatial Epidemiology

James E. De Muth

Andrew B. Lawson

University of Wisconsin - Madison, USA Series: Chapman & Hall/CRC Biostatistics

Medical University of South Carolina, Charleston, USA Series: Chapman & Hall/CRC Interdisciplinary Statistics

Focusing on applications to research, clinical trials, and quality control, Basic Statistics & Pharmaceutical Statistical Applications is a practical, easy-to-use text and reference that builds a basic knowledge of statistics. Accessible and nonthreatening, it discusses all of the commonly used statistical tests and presents them with examples and worked-out results. The emphasis is on correctly interpreting research results rather than on theory. Thoroughly revised and expanded, this edition includes chapters on measures of associations, odds and relative risks ratios, and survival statistics. Other added material addresses process capability, tolerance limits, and reproducibility.

This work provides an overview of the main areas of Bayesian hierarchical modeling and its application to the geographical analysis of disease. It explores a range of topics in Bayesian inference and modeling, including Markov chain Monte Carlo methods, Gibbs sampling, the Metropolis–Hastings algorithm, goodness-of-fit measures, and residual diagnostics. The author explains how to apply these methods to disease mapping using numerous real-world data sets pertaining to cancer, asthma, epilepsy, foot and mouth disease, influenza, and other diseases. Data sets, WinBUGS ODC files, and R code are available on the author’s website.

Catalog no. DK799X, ISBN: 978-0-8493-3799-4 May 2006, 6-1/8 x 9-1/4, 744 pp. Suggested Price: $89.95 / £41.99

Catalog no. C8407, ISBN: 978-1-58488-840-6 August 2008, 6-1/8 x 9-1/4, 368 pp. Suggested Price: $85.95 / £54.99 Available in eBook

Bayesian Analysis for Population Ecology

Textbook

Bayesian Ideas and Data Analysis An Introduction for Scientists and Statisticians

Ruth King, Byron J.T. Morgan, Olivier Gimenez, and Stephen Brooks

Ronald Christensen, Wesley Johnson, Adam Branscum, and Timothy E. Hanson

Series: Chapman & Hall/CRC Interdisciplinary Statistics

Series: Chapman & Hall/CRC Texts in Statistical Science

This book presents up-to-date Bayesian methods for analyzing complex ecological data. It provides a basic introduction to Bayesian methods that assumes no prior knowledge. The book includes detailed descriptions of methods that deal with covariate data and covers techniques at the forefront of research, such as model discrimination and model averaging. Leaders in the statistical ecology field, the authors apply the theory to a wide range of actual case studies and illustrate the methods using WinBUGS and R. The computer programs and full details of the data sets are available on the book’s website.

Emphasizing the use of WinBUGS and R to analyze real data, this text presents statistical tools to address scientific questions. It highlights foundational issues in statistics, the importance of making accurate predictions, and the need for scientists and statisticians to collaborate in analyzing data. The authors cover a large number of statistical models, explore numerical approximations via MCMC simulation, and include numerous exercises and real-world examples. The WinBUGS code provided offers a convenient platform to model and analyze a wide range of data. Code and other materials are available on the book’s website.

Catalog no. K10597, ISBN: 978-1-4398-1187-0 October 2009, 6-1/8 x 9-1/4, 456 pp. Suggested Price: $82.95 / £50.99

Catalog no. K10199, ISBN: 978-1-4398-0354-7 July 2010, 7 x 10, 516 pp. Suggested Price: $69.95 / £44.99

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Textbook

Bayesian Methods for Data Analysis Bayesian Analysis Made Simple An Excel GUI for WinBUGS Phil Woodward Pfizer, LTD, Sandwich, Kent, UK Chapman & Hall/CRC Biostatistics Series

From simple NLMs to complex GLMMs, this book describes how to use the GUI for WinBUGS—BugsXLA—an Excel add-in written by the author that allows a range of Bayesian models to be easily specified. The text shows how to routinely apply even the more complex aspects of model specification, such as GLMMs, outlier robust models, random effects Emax models, auto-regressive errors, and Bayesian variable selection. It provides brief, up-to-date discussions of current issues in the practical application of Bayesian methods. The author also explains how to obtain free software to get started immediately. Catalog no. K11808, ISBN: 978-1-4398-3954-6 May 2011, 6-1/8 x 9-1/4, 300 pp. Suggested Price: $69.95 / £44.99 Available in eBook

Biostatistics

Textbook

Third Edition Bradley P. Carlin University of Minnesota, Minneapolis, USA

Thomas A. Louis Johns Hopkins Bloomberg School of Public Health, Maryland, USA Series: Chapman & Hall/CRC Texts in Statistical Science

This proven text provides an accessible introduction to the foundations and applications of Bayesian analysis. Broadening its scope to nonstatisticians, this edition concentrates more on hierarchical Bayesian modeling as implemented via MCMC methods and related data analytic techniques. It contains a readerfriendly introduction to hierarchical statistical modeling, a new chapter on Bayesian design that emphasizes Bayesian clinical trials, a completely revised and expanded section on ranking and histogram estimation, and a new case study on infectious disease modeling and the 1918 flu epidemic. This edition also includes new data examples, corresponding R and WinBUGS code, and exercises. Catalog no. C6978, ISBN: 978-1-58488-697-6 June 2008, 6-1/8 x 9-1/4, 552 pp. Suggested Price: $69.95 / £44.99

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Textbook

Bayesian Methods A Social and Behavioral Sciences Approach, Second Edition

Biostatistics

Jeff Gill

Models and Designs

Washington University, St. Louis, Missouri, USA Series: Chapman & Hall/CRC Statistics in the Social and Behavioral Science

Damaraju Raghavarao, James B. Wiley and Pallavi Chitturi

Offering a graduate-level introduction to Bayesian statistics for social scientists, this text provides detailed explanations of derivations and theories using a computationally oriented approach. This edition presents many new developments in the field, such as the deviance information criterion, hybrid MCMC algorithms, diagnostics, perfect sampling, and Bayesian nonparametrics. The author emphasizes applications commonly used in the social sciences, including regression models and covariates, and uses the most up-to-date MCMC package in WinBUGS and the new MCMCpack in R. He also supplies detailed advice and guidance on the mechanics of stochastic simulation.

Conjoint analysis (CA) and discrete choice experimentation (DCE) are tools used to facilitate development and modification of products, services, policies, and programs. Building on the authors’ significant work in the field, this book explores the experimental design issues that occur when constructing concept profiles for DCE and CA studies. It shows how to modify commonly used designs and models as well as develop new types of designs for solving DCE and CA problems. Requiring minimal mathematical background, the text explains experimental design concepts through illustrative examples and provides detailed coding of design matrices for standard designs.

Catalog no. C5629, ISBN: 978-1-58488-562-7 November 2007, 6-1/8 x 9-1/4, 752 pp. Suggested Price: $77.95 / £49.99

Catalog no. K10020, ISBN: 978-1-4200-9996-6 August 2010, 6-1/8 x 9-1/4, 192 pp. Suggested Price: $89.95 / £57.99

Temple University, Philadelphia, Pennsylvania, USA

Available in eBook

Edited by

Clinical Trial Data Analysis Using R

Jake Y. Chen

Ding-Geng Chen

Biological Data Mining Indiana University-Purdue University, Indianapolis, USA

Stefano Lonardi University of California, Riverside, USA Series: Chapman & Hall/CRC Data Mining and Knowledge Discovery

Choice-Based Conjoint Analysis

This volume presents comprehensive data mining concepts, theories, and applications in current biological and medical research. The first section of the book discusses challenges and opportunities in analyzing and mining biological sequences and structures to gain insight into molecular functions. The second section addresses emerging computational challenges in interpreting high-throughput Omics data. The book then describes the relationships between data mining and related areas of computing, including knowledge representation, information retrieval, and data integration for structured and unstructured biological data. The last part explores data mining opportunities for biomedical applications. Catalog no. C6847, ISBN: 978-1-4200-8684-3 September 2009, 6-1/8 x 9-1/4, 733 pp. Suggested Price: $99.95 / £65.99

Georgia Southern University, Statesboro, USA

Karl E. Peace Jiann-Ping Hsu College of Public Health, Georgia Southern University, Statesboro, USA Chapman & Hall/CRC Biostatistics Series

With examples based on the authors’ 30 years of real-world experience in many areas of clinical drug development, this book provides a thorough presentation of clinical trial methodology. It presents detailed step-by-step illustrations on the implementation of the open-source software R. Case studies demonstrate how to select the appropriate clinical trial data. The authors introduce the corresponding biostatistical analysis methods, followed by the step-by-step data analysis using R. They also offer the R program for download, along with other essential data, on their website. Catalog no. K11861, ISBN: 978-1-4398-4020-7 December 2010, 6-1/8 x 9-1/4, 387 pp. Suggested Price: $89.95 / £57.99 Available in eBook

Available in eBook

Textbook

Cluster Randomised Trials

Biostatistics

Richard J. Hayes

A Computing Approach

Lawrence H. Moulton

London School of Hygiene & Tropical Medicine, London, UK

Stewart Anderson University of Pittsburgh, Pennsylvania, USA Series: Chapman & Hall/CRC Texts in Statistical Science

Focusing on visualization and computational approaches with an emphasis on the importance of simulation, Biostatistics introduces modern and classical biostatistical methods and compares their respective usefulness. The book covers essential topics in biostatistical science, including simple linear regression, multivariate regression, repeated measure, nonparametric analysis, survival analysis, sample size, and power calculations. Assuming only basic knowledge of probability and statistics, the text offers numerous practical applications and detailed worked examples taken from the medical area, all computed using R and SAS, as well as exercises with solutions. Catalog no. C8342, ISBN: 978-1-58488-834-5 June 2011, 6-1/8 x 9-1/4, 416 pp., Soft Cover Suggested Price: $79.95 / £39.99

Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA Series: Chapman & Hall/CRC Interdisciplinary Statistics

This book presents simple methods that are easy to apply with readily available statistical software and that perform well under the conditions experienced in most CRTs. It provides substantial material on study design options and includes a variety of practical examples from both developing and industrialized countries, with many of the examples based on the authors’ own research. The book also illustrates the application of analytical methods through several data sets from actual trials and shows how data can be analyzed using Stata. The data sets are available for download online. Catalog no. C8164, ISBN: 978-1-58488-816-1 January 2009, 6-1/8 x 9-1/4, 338 pp. Suggested Price: $92.95 / £56.99 Available in eBook

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Textbook

Design of Experiments

John D. MacCuish and Norah E. MacCuish

An Introduction Based on Linear Models

Mesa Analytics & Computing, Inc., Santa Fe, New Mexico, USA Series: Chapman & Hall/CRC Mathematical & Computational Biology

Max D. Morris Iowa State University, Ames, USA Series: Chapman & Hall/CRC Texts in Statistical Science

With a DVD of color figures, this book provides an expert guide on extracting the most pertinent information from pharmaceutical and biomedical data. It offers a concise overview of common and recent clustering methods used in bioinformatics and drug discovery. The authors cover the clustering of small and large data sets, parallelization of clustering algorithms, validation and visualization, asymmetric clustering, and clustering ambiguity. They provide many real-world examples from industrial settings, such as combinatorial library design and compound databases, and include exercises at the end of each chapter.

This text explores how experiments are designed using the language of linear statistical models. It presents an organized framework for understanding the statistical aspects of experimental design as a whole within the structure provided by general linear models. The text describes specific forms or classes of experimental designs, incorporates actual experiments drawn from the scientific and technical literature, and includes many end-of-chapter exercises. Calculations are performed using R, with commands provided in an appendix. A solutions manual is available for qualifying instructors.

Catalog no. K10863, ISBN: 978-1-4398-1678-3 November 2010, 6-1/8 x 9-1/4, 244 pp. Suggested Price: $79.95 / £49.99

Catalog no. C9233, ISBN: 978-1-58488-923-6 July 2010, 6-1/8 x 9-1/4, 370 pp. Suggested Price: $89.95 / £39.99

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Gilbert Mackenzie

Dose Finding by the Continual Reassessment Method

Limerick University, Ireland Series: Chapman & Hall/CRC Monographs on Statistics & Applied Probability

Ying Kuen Cheung Department of Biostatistics, Columbia University, USA Chapman & Hall/CRC Biostatistics Series

Written by a researcher at the forefront of the field, this book expounds on modern theory of covariance modelling in which regression models are used to model the covariance structure simultaneously with the mean. In a systematic treatment, quite possibly the first available in a convenient format, the author then compares the results obtained to conventional methods and delineates why the new methodology is advantageous using a series of classical examples taken from the existing literature.

This book presents the continual reassessment method (CRM) as a tool for dosefinding studies. With a focus on the implementation and practice of the CRM and its variations, it explains how the CRM may be calibrated and extended to suit common clinical settings. The book includes examples of real clinical trials data to illustrate the calibration techniques and shows how R can be used to carry out the techniques. It reviews the literature, related methodology, and theoretical properties of the CRM. It also explores alternatives for situations where the CRM fails.

Covariance Modelling

Catalog no. C6080, ISBN: 978-1-58488-608-2 June 2011, 6 x 9, 256 pp. Suggested Price: $79.95 / £49.99 Available in eBook

Catalog no. C9151, ISBN: 978-1-4200-9151-9 March 2011, 6-1/8 x 9-1/4, 200 pp. Suggested Price: $79.95 / £49.99 Available in eBook

Textbook Textbook

Design and Analysis of Experiments with SAS John Lawson Brigham Young University, Provo, Utah, USA Series: Chapman & Hall/CRC Texts in Statistical Science

This textbook covers both classical ideas in experimental design and the latest research topics. It clearly discusses the objectives of a research project that lead to an appropriate design choice, the practical aspects of creating a design and performing experiments, and the interpretation of the results of computer data analysis. Using SAS 9.2 to illustrate the construction of experimental designs and analysis of data, the author presents many applications from the pharmaceutical, agricultural, industrial chemicals, and machinery industries. SAS code and ancillaries are available on the author’s website. Catalog no. C6060, ISBN: 978-1-4200-6060-7 May 2010, 6-1/8 x 9-1/4, 596 pp. Suggested Price: $99.95 / £63.99

Exercises and Solutions in Biostatistical Theory Lawrence L. Kupper University of North Carolina, Chapel Hill, USA

Brian Neelon Sean M. O’Brien Duke University School of Medicine, Durham, North Carolina, USA Series: Chapman & Hall/CRC Texts in Statistical Science

Drawn from nearly four decades of Lawrence L. Kupper’s teaching experiences, this text presents theoretical statistical concepts, numerous exercises, and detailed solutions that span topics from basic probability to statistical inference. The text links theoretical principles to real-world situations, including some of the authors’ own biostatistical work that has addressed complicated design and analysis issues in the health sciences. The authors explain the biostatistical principles needed to solve the exercises, which range in level of difficulty from fairly basic to more challenging. Catalog no. C7222, ISBN: 978-1-58488-722-5 November 2010, 6-1/8 x 9-1/4, 420 pp., Soft Cover Suggested Price: $49.95 / £24.99

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Biostatistics

Clustering in Bioinformatics and Drug Discovery

Exploratory Multivariate Analysis by Example Using R

Biostatistics

Francois Husson, Sebastien Le, and Jerome Pages

Frailty Models in Survival Analysis

AGROCAMPUS OUEST, Rennes, France Series: Chapman & Hall/CRC Computer Science & Data Analysis

Andreas Wienke Martin-Luther-University Halle-Wittenberg, Germany Chapman & Hall/CRC Biostatistics Series

Full of real-world case studies and practical advice, this book focuses on four fundamental methods of multivariate exploratory data analysis that are most suitable for applications. It covers principal component analysis when variables are quantitative, correspondence analysis and multiple correspondence analysis when variables are categorical, and hierarchical cluster analysis. The authors take a geometric point of view that provides a unified vision for exploring multivariate data tables. All of the data sets and code are available on the book’s website.

Accessible to nonspecialists, this book explains the basic ideas in frailty modeling and statistical techniques, with a focus on real data application and interpretation of the results. It extensively explores how univariate frailty models can represent unobserved heterogeneity. It also emphasizes correlated frailty models as extensions of univariate and shared frailty models. The author analyzes similarities and differences between frailty and copula models, discusses problems related to frailty models, and describes parametric and semiparametric models using both frequentist and Bayesian approaches. The author demonstrates realworld applications using R, SAS, and Stata.

Catalog no. K11614, ISBN: 978-1-4398-3580-7 November 2010, 6-1/8 x 9-1/4, 240 pp. Suggested Price: $79.95 / £49.99 Available in eBook

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Textbook

Extending the Linear Model with R Generalized Linear, Mixed Effects and Nonparametric Regression Models

Catalog no. C7388, ISBN: 978-1-4200-7388-1 July 2010, 6-1/8 x 9-1/4, 312 pp. Suggested Price: $99.95 / £63.99

Gaussian Process Regression Analysis for Functional Data Jian Qing Shi

Julian J. Faraway

University of Newcastle upon Tyne, UK

University of Bath, UK Series: Chapman & Hall/CRC Texts in Statistical Science

Korea University, Seoul, Korea

Julian J. Faraway’s critically acclaimed Linear Models with R thoroughly examined the different methods available and showed in which situations each one applies. Following in those footsteps, his new book surveys the techniques that grow from the regression model, presenting three extensions to that framework: generalized linear models, mixed effect models, and nonparametric regression models. It provides a well-stocked toolbox of methodologies, and with its unique presentation of these very modern statistical techniques, holds the potential to break new ground in the way graduate-level courses in this area are taught. Catalog no. C424X, ISBN: 978-1-58488-424-8 December 2005, 6-1/8 x 9-1/4, 312 pp. Suggested Price: $89.95 / £45.99

Textbook

A First Course in Linear Model Theory

Taeryon Choi A Gaussian process is a type of stochastic process that is particularly useful for Bayesian inference of complex problems. This book presents an overview of Gaussian process regression, all of the necessary theory, and real-world applications from the fields of medicine and engineering. It covers the required background in regression and examines key aspects of the modeling process, including model selection as well as more advanced topics, such as mixture models and kernelbased methods. For implementing the methods discussed in the text, the authors provide ad hoc software for download on their website. Catalog no. K11716, ISBN: 978-1-4398-3773-3 June 2011, 6-1/8 x 9-1/4, 224 pp. Suggested Price: $99.95 / £63.99 Available in eBook

Textbook

Generalized Additive Models An Introduction with R

Nalini Ravishanker and Dipak K. Dey

Simon N. Wood

University of Connecticut, Storrs, USA Series: Chapman & Hall/CRC Texts in Statistical Science

University of Bath, England, UK Series: Chapman & Hall/CRC Texts in Statistical Science

This intermediate-level statistics text presents the theory of linear statistical models at a level appropriate for senior undergraduate or first-year graduate students. It systematically presents the basic theory behind linear statistical models with motivation from an algebraic as well as a geometric perspective. Through the concepts and tools of matrix and linear algebra and distribution theory, it provides a framework for understanding classical and contemporary linear model theory. It develops in students the art of statistical thinking and inspires learning at an intuitive level by emphasizing conceptual understanding.

Generalized Additive Models: An Introduction with R imparts a thorough understanding of the theory and practical applications of GAMs and related advanced models, enabling informed use of these flexible tools. The author’s approach is based on a framework of penalized regression splines, and he builds the necessary foundation through motivating chapters on linear and generalized linear models. Use of the freely available R software helps explain the theory and illustrates the practicalities of linear, generalized linear, and generalized additive models, as well as their mixed effect extensions.

Catalog no. C2476, ISBN: 978-1-58488-247-3 December 2001, 6-1/8 x 9-1/4, 496 pp. Suggested Price: $94.95 / £41.99

Catalog no. C4746, ISBN: 978-1-58488-474-3 February 2006, 6-1/8 x 9-1/4, 410 pp. Suggested Price: $89.95 / £56.99

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Multilevel, Longitudinal, and Structural Equation Models

A Handbook of Statistical Analyses Using R Second Edition

Anders Skrondal

Brian S. Everitt

London School of Economics, UK

King’s College, University of London, UK

Sophia Rabe-Hesketh

Torsten Hothorn

University of California, Berkeley, USA

Ludwig-Maximilians-Universität München, Germany

Generalized Latent Variable Modeling: Multilevel, Longitudinal, and Structural Equation Models unifies and extends latent variable models, including multilevel or generalized linear mixed models, longitudinal or panel models, item response or factor models, latent class or finite mixture models, and structural equation models. Following a gentle introduction to latent variable modeling, the authors clearly explain a wide range of estimation and prediction methods. Exciting, realistic applications demonstrate how latent variable modeling can be used to solve problems in areas as diverse as medicine, economics, and psychology.

Like its bestselling predecessor, this second edition provides a guide to data analysis using the R system for statistical computing. This edition contains new chapters on graphical displays, generalized additive models, and simultaneous inference as well as a new section on generalized linear mixed models that completes the discussion on the analysis of longitudinal data where the response variable does not have a normal distribution. The authors include new examples and additional exercises in several chapters. They also offer a new version of the HSAUR package (HSAUR2), which is available from CRAN.

Catalog no. C80007, ISBN: 978-1-58488-000-4 May 2004, 6-1/8 x 9-1/4, 528 pp. Suggested Price: $104.95 / £65.99

Catalog no. C7933, ISBN: 978-1-4200-7933-3 July 2009, 6-1/8 x 9-1/4, 376 pp., Soft Cover Suggested Price: $57.95 / £36.99 Available in eBook

Available in eBook

Generalized Linear Models and Extensions Second Edition

A Handbook of Statistical Analyses using SAS

Biostatistics

Generalized Latent Variable Modeling

Third Edition

James Hardin University of South Carolina, Columbia, USA

Geoff Der

Joseph Hilbe

University of Glasgow, Scotland, UK

Jet Propulsion Laboratory, California Institute of Technology, Pasadena, California and Arizona State University, Tempe, USA

Brian S. Everitt UK King’s College, University of London, UK

This book presents a thorough examination of generalized linear model (GLM) estimation methods as well as the derivation of all major GLM families. Examined families include Gaussian, gamma, inverse Gaussian, binomial, Poisson, geometric, and negative binomial. The text also contains various models that have been developed on the basis of GLM theory, including GAM, ordered binomial models, multinomial logit and probit models, GEE and other quasilikelihood models, fixed and random effects models, and random intercept and random parameter models. Using Stata, the book offers numerous examples to assist you in applying the models to your own data situations.

This third edition of a bestseller explains how to conduct a range of statistical analyses using the latest version of SAS. It illustrates each type of analysis with numerous real-world data examples, such as environmental causes of diseases, hypertension treatment, and gastric cancer treatment. This edition presents the new graphics procedures of SAS 9.2. It also includes more end-of-chapter exercises and selected answers in the appendix, along with a solutions manual that provides SAS code, output, and comments. The SAS programs and data sets used in the book are available online.

Catalog no. SZ0149, ISBN: 978-1-59718-014-6 February 2007, 387 pp., Soft Cover Suggested Price: $87.95 / £58.99

Handbook of Markov Chain Monte Carlo Edited by

Steve Brooks, Andrew Gelman, Galin Jones, and Xiao-Li Meng

Catalog no. C7842, ISBN: 978-1-58488-784-3 December 2008, 6-1/8 x 9-1/4, 392 pp., Soft Cover Suggested Price: $59.95 / £37.99

Handbook of Statistical Analyses Using Stata Fourth Edition Sophia Rabe-Hesketh University of California, Berkeley, USA

Brian S. Everitt

Series: Chapman & Hall/CRC Handbooks of Modern Statistical Methods

UK King’s College, University of London, UK

Handbook of Markov Chain Monte Carlo brings together the major advances that have occurred in recent years while incorporating enough introductory material for new users of MCMC. Along with thorough coverage of the theoretical foundations and algorithmic and computational methodology, this comprehensive handbook includes substantial realistic case studies from a variety of disciplines. These case studies demonstrate the application of MCMC methods and serve as a series of templates for the construction, implementation, and choice of MCMC methodology.

Fully updated, the fourth edition of this highly acclaimed and perpetually bestselling text demonstrates how a wide variety of statistical analyses, including descriptive statistics, graphics, and model estimation and diagnostics, can be performed using Stata version 9. The authors present many of Stata’s novel features, including a new mixed-models estimation command and a new matrix language. This edition also contains additional exercises that use various data sets and numerous examples of real-life data, enabling a better understanding of the methodology. The book offers selected solutions and a solutions manual.

Catalog no. C7941, ISBN: 978-1-4200-7941-8 May 2011, 7 x 10, 480 pp. Suggested Price: $99.95 / £63.99

Catalog no. C7567, ISBN: 978-1-58488-756-0 November 2006, 6 x 9, 352 pp., Soft Cover Suggested Price: $67.95 / £42.99

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Hierarchical Modeling and Analysis for Spatial Data Second Edition University of Minnesota, Minneapolis, USA

An Introduction to Stata for Health Researchers

Alan E. Gelfand

Third Edition

Duke University, Durham, North Carolina, USA Series: Chapman & Hall/CRC Monographs on Statistics & Applied Probability

Svend Juul and Morten Frydenberg

Sudipto Banerjee and Brad P. Carlin

Biostatistics

Hierarchical Modeling and Analysis for Spatial Data is the first accessible, upto-date treatment of Bayesian methods, modeling, and data analysis for spatial and spatio-temporal data. Self-contained, it includes overviews of the necessary background material, exercises, and brief tutorial on using S+SpatialStats, geoR, and WinBUGS software for hierarchical spatial modeling. This book provides clear explanations, plentiful illustrations--some in full color--and lays the groundwork for using easily accessible software to immediately apply the techniques to your data. Catalog no. K11011, ISBN: 978-1-4398-1917-3 June 2011, 6 x 9, 608 pp. Suggested Price: $89.95 / £57.99

Catalog no. N10327, ISBN: 978-1-59718-077-1 August 2010, 7 3/8 x 9 1/4, 340 pp., Soft Cover Suggested Price: $79.95 / £49.99

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Integrated Microsystems Materials, MEMs, Photonics, Bio Interfaces Edited by

Krzysztof Iniewski CMOS Emerging Technologies Inc., Vancouver, British Columbia Series: Devices, Circuits, and Systems

This book focuses on electrical engineering and elaborates on how electrical circuits interface with biology, microfluidics, and photonics. Including only light math and physics, with greater focus on explanation, it covers integrated devices and other emerging structures required for future micro- and nanotechnologies. This material addresses physical and chemical sensing, imaging, smart actuation, and data fusion and management. Providing tables, figures, and equations to help illustrate concepts, the book’s contributors examine and explain the potential of emerging applications that are in integrated microsystems.

Aarhus University, Denmark

This book continues to systematically cover data management, simple description and analysis, and more advanced analyses that are most often used in health research, such as regression models, survival analysis, measurement, and diagnosis. It also describes many graph types as well as how to modify the appearance of a graph. This third edition presents some of the new features in Stata 11, including the new, flexible syntax for factor variables. It also incorporates Stata 11 in the rewritten chapters on regression and survival analysis. Robust data sets can be downloaded from the book’s website.

Catalog no. K11637, ISBN: 978-1-4398-3620-0 May 2011, 6-1/8 x 9-1/4, 425 pp. Suggested Price: $139.95 / £89.00

Textbook

Introduction to Statistical Data Analysis for the Life Sciences Claus Thorn Ekstrom and Helle Sorensen University of Copenhagen, Denmark

Developed from the authors’ courses, this text provides a computational toolbox that enables readers to perform actual analysis for real data sets as well as the confidence and skills to undertake more sophisticated analyses as their careers progress. While the main text can be used with any statistical software, the authors encourage a reliance on R. They provide a short tutorial for those new to the software and include R commands and output at the end of each chapter. Data sets used in the book are available on a supporting website. Catalog no. K11221, ISBN: 978-1-4398-2555-6 August 2010, 6-1/8 x 9-1/4, 427 pp., Soft Cover Suggested Price: $69.95 / £31.99

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Textbook

An Introduction to Generalized Linear Models Third Edition Annette J. Dobson University of Queensland, Herston, Australia

Adrian G. Barnett Queensland University of Technology, Kelvin Grove, Australia Series: Chapman & Hall/CRC Texts in Statistical Science

Updated with Stata, R, and WinBUGS code as well as three new chapters on Bayesian analysis, this new edition of a bestseller continues to provide a cohesive framework for statistical modeling. Emphasizing numerical and graphical methods, it enables readers to understand the unifying structure that underpins GLMs. The text discusses common concepts and principles of advanced GLMs, including nominal and ordinal regression, survival analysis, and longitudinal analysis. It contains numerous examples from business, medicine, engineering, and the social sciences and offers the data sets and solutions to the exercises online. Catalog no. C9500, ISBN: 978-1-58488-950-2 May 2008, 6-1/8 x 9-1/4, 320 pp., Soft Cover Suggested Price: $62.95 / £39.99

Textbook

Introduction to Statistical Limit Theory Alan M. Polansky Northern Illinois University, Dekalb, USA Series: Chapman & Hall/CRC Texts in Statistical Science

Those moving on to advanced statistics typically lack the mathematical foundation that allows them to make full use of statistical limit theory. This accessible resource reviews approximation theory and limit theory for sequences of functions and basic notions of functional analysis. It provides detailed arguments that show how underlying mathematical and statistical theory work together. Among its unique qualities, the text covers expansion theory, which is becoming increasingly important in modern applications. It also discusses bootstrap, kernel smoothing, and Markov chain Monte Carlo and includes a wide array of examples and problems. Catalog no. C6604, ISBN: 978-1-4200-7660-8 January 2011, 6-1/8 x 9-1/4, 640 pp. Suggested Price: $89.95 / £57.99 Available in eBook

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Third Edition

Longitudinal Data Analysis

Mario Cleves

Edited by

University of Arkansas for Medical Sciences, Little Rock, USA

Garrett Fitzmaurice, Marie Davidian, Geert Verbeke, and Geert Molenberghs

William Gould, Roberto Gutierrez, and Yulia Marchenko StataCorp LP, College Station, Texas, USA

This book provides the foundation to understand various approaches for analyzing time-to-event data. This updated third edition highlights new features of Stata 11, including competing-risks analysis and the treatment of missing values via multiple imputation. Other additions include new diagnostic measures after Cox regression, Stata’s new treatment of categorical variables and interactions, and a new syntax for obtaining prediction and diagnostics after Cox regression. The book helps you understand the formulas, gain intuition about how survival analysis estimators work and what information they exploit, and acquire deeper, more comprehensive knowledge of Stata’s survival analysis routines. Catalog no. N10331, ISBN: 978-1-59718-074-0 September 2010, 7 3/8 x 9 1/4, 412 pp., Soft Cover Suggested Price: $79.95 / £49.99

Linear Mixed Models A Practical Guide Using Statistical Software Brady T. West, Kathleen B. Welch, and Andrzej T Galecki University of Michigan, Ann Arbor, USA

Series: Chapman & Hall/CRC Handbooks of Modern Statistical Methods

This collection provides a clear, comprehensive, and unified overview of recent developments in statistical methods for the analysis of longitudinal data. Focusing on both theory and applications, it addresses challenges that arise in analyzing longitudinal data, emphasizes statistical models and methods likely to endure in the future, highlights connections between various research threads in the statistical literature, and contains numerous examples and case studies drawn from a range of disciplines. Data sets, software programs, and other material are available on the editors’ website. Catalog no. C6587, ISBN: 978-1-58488-658-7 August 2008, 7 x 10, 632 pp. Suggested Price: $99.95 / £62.99 Available in eBook

Measurement Error in Nonlinear Models A Modern Perspective, Second Edition Raymond J. Carroll, David Ruppert, Leonard A. Stefanski, and Ciprian M. Crainiceanu Series: Chapman & Hall/CRC Monographs on Statistics & Applied Probability

This easy-to-use resource provides a clear explanation of mixed modeling techniques and theories and demonstrates the use of popular statistical software procedures for fitting linear mixed models (LMMs). The authors fit LMMs based on both general and hierarchical model specifications, develop the model-building process step-by-step, and demonstrate the estimation, testing, and interpretation of fixed-effect parameters and covariance parameters associated with random effects. These concepts are illustrated through examples of real-world data sets using R, SAS, SPSS, HLM, and Stata that enable comparison of model fitting options and results across the software procedures. A supporting website provides software code and the data sets discussed in the book.

Measurement Error in Nonlinear Models: A Modern Perspective, Second Edition provides an up-to-date overview of analysis strategies for regression models in which variables are measured with errors. Thoroughly revised, this second edition includes additional material on Bayesian methods and semiparametric regression and a new chapter on generalized linear mixed models. Focusing on general ideas and strategies of estimation and inference, the authors provide various detailed worked examples, computed using MATLAB and R, from the fields of epidemiology and biometry. Data sets and software for all of the examples are available for download from the Internet.

Catalog no. C4800, ISBN: 978-1-58488-480-4 November 2006, 7 x 10, 376 pp. Suggested Price: $89.95 / £56.99

Catalog no. C331X, ISBN: 978-1-58488-633-4 June 2006, 6 x 9, 488 pp. Suggested Price: $104.95 / £65.99

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Textbook

Measures of Interobserver Agreement and Reliability

Linear Models with R

Mohamed M. Shoukri

Julian J. Faraway

Biostatistics

An Introduction to Survival Analysis Using Stata

Second Edition

University of Bath, United Kingdom Series: Chapman & Hall/CRC Texts in Statistical Science

King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia Chapman & Hall/CRC Biostatistics Series

Linear Models with R focuses on the practice of regression and analysis of variance. It demonstrates the different methods available in which situations each one applies. It covers all of the standard topics, from the basics of estimation to missing data, factorial designs, and block designs. It also includes discussion on topics rarely addressed in books of this type, such as model uncertainty. The presentation incorporates examples that clarify both the use of each technique and conclusions. All of the data sets used in the book are available for download from the Internet.

Emphasizing applications over theory, this book provides a comprehensive survey of this method and provides readers with standards and directions on how to run sound clinical and other types of studies. The author clearly explains how to reduce measurement error and presents numerous practical examples of the interobserver agreement approach. To help with problem solving, he includes SAS code, both within the book and on the CRC website. This edition presents new applications, new tables, more detail on SAS, new code, updated references, and two new chapters.

Catalog no. C4258, ISBN: 978-1-58488-425-5 August 2004, 6-1/8 x 9-1/4, 240 pp. Suggested Price: $82.95 / £45.99

Catalog no. K10539, ISBN: 978-1-4398-1080-4 December 2010, 6-1/8 x 9-1/4, 288 pp. Suggested Price: $99.95 / £63.99 Available in eBook

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Textbook

Medical Biostatistics Second Edition

Biostatistics

Abhaya Indrayan

Second Edition

University College of Medical Science, Delhi, India Chapman & Hall/CRC Biostatistics Series

Malcolm Haddon

Demonstrating how biostatistics helps manage medical uncertainties, this comprehensive edition covers numerous biostatistical methods used in evidencebased patient management, medical research, and health administration. New chapters describe clinical trials, observational studies, laboratory experiments, survival analysis, logistic regression, and clinimetrics. With more real-world examples, this edition also expands discussions on epistemic uncertainties, crossover designs, and equivalence trials. In addition to conventional statistical procedures, it discusses reliability and validity evaluations, quality control methods, and the robustness of results.

This book provides an accessible introduction to quantitative methods in fisheries. This book features new material on tests and comparisons as well as new chapters on length-based models and estimating uncertainty using Bayesian methods. It presents a structured, step-by-step approach that introduces the material in a logical sequence. This text covers a range of topics such as simple linear regression, complex nonlinear modeling, methodology, and specific fields in fisheries. It also includes numerous real-world examples implemented in Excel, with workbooks for all examples available for download on the web.

Catalog no. C8873, ISBN: 978-1-58488-887-1 March 2008, 6-1/8 x 9-1/4, 824 pp. Suggested Price: $99.95 / £63.99

Missing Data in Longitudinal Studies Strategies for Bayesian Modeling and Sensitivity Analysis Michael J. Daniels

Modelling and Quantitative Methods in Fisheries University of Tasmania, Australia

Catalog no. C561X, ISBN: 978-1-58488-561-0 January 2011, 6-1/8 x 9-1/4, 471 pp. Suggested Price: $79.95 / £39.99

Textbook

Modelling Survival Data in Medical Research Second Edition

University of Florida, Gainesville, USA

David Collett

Joseph W. Hogan Brown University, Providence, Rhode Island, USA

UK Transplant, Bristol, UK Series: Chapman & Hall/CRC Texts in Statistical Science

This book provides a unified Bayesian approach to handle missing data in longitudinal studies. It contains examples and case studies on schizophrenia, aging, HIV, and smoking cessation. The authors describe assumptions that include MAR and ignorability, demonstrate the importance of covariance modeling with incomplete data, and cover mixture and selection models for nonignorable missingness. They also present methods for representing untestable assumptions using prior distributions. Several analyses deal with nonignorable missingness as well as illustrate the models and methods. Many analyses are implemented using WinBUGS, with the code provided on a supplementary web page.

The second edition of Modelling Survival Data in Medical Research has been thoroughly revised and updated to reflect the many developments and advances— particularly in software—made in the field over the last 10 years. It provides an outstanding text for upper-level and graduate courses in survival analysis, biostatistics, and time-to-event analysis. This edition features a more detailed treatment of topics such as parametric models, accelerated failure time models, and analysis of interval-censored data. The author also focuses the software section on the use of SAS, summarizing the methods used by the software to generate its output and examining that output in detail.

Catalog no. C6099, ISBN: 978-1-58488-609-9 March 2008, 6-1/8 x 9-1/4, 328 pp. Suggested Price: $85.95 / £54.99

Catalog no. C3251, ISBN: 978-1-58488-325-8 March 2003, 6-1/8 x 9-1/4, 408 pp., Soft Cover Suggested Price: $79.95 / £49.99

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Mixed Effects Models for Complex Data

Monte Carlo Simulation for the Pharmaceutical Industry

Lang Wu

Concepts, Algorithms, and Case Studies

University of British Columbia, Vancouver, Canada Series: Chapman & Hall/CRC Monographs on Statistics & Applied Probability

Mark Chang AMAG Pharmaceuticals, Lexington, Massachusetts, USA Chapman & Hall/CRC Biostatistics Series

Presenting effective approaches to address missing data, measurement errors, censoring, and outliers in longitudinal data, this book covers linear, nonlinear, generalized linear, nonparametric, and semiparametric mixed effects models. It links each mixed-effects model with the corresponding class of regression model for cross-sectional data and discusses computational strategies for likelihood estimations of mixed effects models. The author briefly describes generalized estimating equations methods and Bayesian mixed effects models and explains how to implement standard models using R and S-Plus. The real-world data examples used throughout encompass studies on mental distress, AIDS, and more.

Helping you become a skillful “simulator,” this book provides broad coverage of the drug development process, from drug discovery to preclinical and clinical trial aspects to commercialization. It presents the theories and methods for carrying out computer simulations efficiently, covers both descriptive and pseudocode algorithms that provide the basis for implementing the simulation methods, and illustrates real-world problems through case studies. The author discusses many key topics, including game theory, adaptive design, molecular design, prescription drug marketing, biological pathway simulation, genetic programming, and pharmacokinetic modeling.

Catalog no. C7402, ISBN: 978-1-4200-7402-4 November 2009, 6-1/8 x 9-1/4, 431 pp. Suggested Price: $89.95 / £57.99

Catalog no. K11621, ISBN: 978-1-4398-3592-0 September 2010, 6-1/8 x 9-1/4, 564 pp. Suggested Price: $89.95 / £57.99

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Multiple Comparisons Using R Novartis Pharma AG, Basel, Switzerland

Torsten Hothorn

Optimal Design for Nonlinear Response Models

Ludwig-Maximilians-Universität München, Germany

Valerii V. Fedorov and Sergei L. Leonov

Peter Westfall

GlaxoSmithKline, Collegeville, Pennsylvania, USA Series: Chapman & Hall/CRC Biostatistics

Texas Tech University, Lubbock, USA

Controlling multiplicity in experiments ensures better decision making and safeguards against false claims. Adopting a unifying theme based on maximum statistics, this self-contained introduction describes the common underlying theory of multiple comparison procedures through numerous examples. It covers a range of multiple comparison procedures, from the Bonferroni method and Simes’ test to resampling and adaptive design methods. The book also presents a detailed description of available software implementations in R. The R packages and source code for the analyses are available at http://CRAN.R-project.org Catalog no. C5742, ISBN: 978-1-58488-574-0 July 2010, 6-1/8 x 9-1/4, 205 pp. Suggested Price: $79.95 / £49.99 Available in eBook

This book examines the theory of optimal model-based design and provides examples of optimal designs for various models, mostly related to biopharmaceutical applications, such as dose-response studies. The authors pay special attention to adaptive or sequential optimal designs for nonlinear regression models when estimation and optimal design are performed in stages. Ideal for researchers in regression analysis and experimental design, the text illustrates optimal designs for various models using an example of the application of a first-order optimization algorithm in the space of information matrices, which is implemented in both MATLAB® and SAS. Catalog no. K11140, ISBN: 978-1-4398-2151-0 June 2011, 6-1/8 x 9-1/4, 300 pp. Suggested Price: $89.95 / £57.99 Available in eBook

Biostatistics

Frank Bretz

Multivariate Geostatistical Models Inference and Computation Hao Zhang Purdue University, West Lafayette, Indiana, USA Series: Chapman & Hall/CRC Monographs on Statistics & Applied Probability

Multivariate geostatistical data involves the observation of two or more spatial processes at spatial and/or temporal points. The objective of such analysis is to estimate the correlation or dependence structure between the multiple variable or to predict the multiple variable at unsampled locations. Multivariate Geostatistical Models provides complete coverage of all key topics in this area, including modeling and estimating the multivariate covariogram, multivariate spatial generalized linear mixed models, and multivariate non-Gaussian models. Illustrated with detailed worked examples from a range of disciplines, the book implements methods using Markov chain Monte Carlo (MCMC) simulation for Bayesian inference. Catalog no. C6994, ISBN: 978-1-58488-699-0 June 2011, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $89.95 / £57.99

Practical Statistical Methods A SAS Programming Approach Lakshmi Padgett Centocor, Malvern, Pennsylvania, USA

This reference presents a broad range of statistical methods for a diverse audience. It first introduces fundamental concepts from statistics and then discusses data analysis and regression. Later chapters cover diverse topics such as interim analysis, propensity scores, and competing risks. The author provides SAS code for the analyses of widely encountered research problems found in a range of disciplines, including medical research, the pharmaceutical industry, and the social sciences. While SAS code and output is integrated into the text, a supporting website includes all of the data sets and SAS code. Catalog no. K10634, ISBN: 978-1-4398-1282-2 April 2011, 6-1/8 x 9-1/4, 352 pp. Suggested Price: $79.95 / £49.99 Available in eBook

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Textbook Textbook

Multivariate Statistical Methods A Primer, Third Edition

Practical Statistics for Medical Research Douglas G. Altman

Western EcoSystem Technology, Inc., Laramie, Wyoming, USA

Centre for Statistics in Medicine, Oxford, UK Series: Chapman & Hall/CRC Texts in Statistical Science

This is a thoroughly revised, updated edition of a best-selling introductory textbook and primer. The third edition retains the author’s trademark clear, concise style and focus on examples in the biological and environmental sciences. New to this edition are fully updated references as well as additional examples and exercises from the social and environmental sciences. While not linking the book to any specific software package, the book now includes an appendix comparing and contrasting various statistical software packages, such as Stata, Statistica, SAS, and Genstat.

Practical Statistics for Medical Research is a problem-based text for medical researchers who need to use statistics but have no specialized mathematics background. The author draws on 20 years of experience as a consulting medical statistician to provide clear explanations of key statistical concepts, with a firm emphasis on practical aspects of designing and analyzing medical research. Using real data and including dozens of interesting data sets, this bestselling text gives special attention to the presentation and interpretation of results and the many real problems that arise in medical research.

Catalog no. C4142, ISBN: 978-1-58488-414-9 July 2004, 6-1/8 x 9-1/4, 224 pp., Soft Cover Suggested Price: $60.95 / £39.99

Catalog no. C7630, ISBN: 978-0-412-27630-9 November 1990, 6-1/8 x 9-1/4, 624 pp. Suggested Price: $99.95 / £62.99

Bryan F.J. Manly

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Robust Nonparametric Statistical Methods Second Edition Thomas P. Hettmansperger Pennsylvania State University, University Park, USA

Joseph W. McKean Western Michigan University, Kalamazoo, USA Series: Chapman & Hall/CRC Monographs on Statistics & Applied Probability

Biostatistics

Often referred to as distribution-free methods, nonparametric methods do not rely on assumptions that the data are drawn from a given probability distribution. With an emphasis on Wilcoxon rank methods that enable a unified approach to data analysis, this book presents a unique overview of robust nonparametric statistical methods. Drawing on examples from various disciplines, the relevant R code for these examples, as well as numerous exercises for self-study, the text covers location models, regression models, designed experiments, and multivariate methods. This edition features a new chapter on cluster correlated data. Catalog no. K10449, ISBN: 978-1-4398-0908-2 December 2010, 7 x 10, 551 pp. Suggested Price: $99.95 / £63.99

Wei Liu University of Southampton, UK Series: Chapman & Hall/CRC Monographs on Statistics & Applied Probability

With examples and MATLAB® programs that make it easy to apply the methods to your own data analysis, this book provides a thorough overview of the construction methods and applications of simultaneous confidence bands for various inferential purposes. Most of the text covers normal-error linear regression models, although the author also describes the logistic regression model to show how simultaneous confidence bands can be constructed and used for generalized linear regression models. The MATLAB programs, along with color figures, are available for download on the author’s website. Catalog no. K11385, ISBN: 978-1-4398-2809-0 October 2010, 6-1/8 x 9-1/4, 292 pp. Suggested Price: $89.95 / £57.99 Available in eBook

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SAS and R Data Management, Statistical Analysis, and Graphics Ken Kleinman Harvard Medical School, Boston, Massachusetts, USA

Nicholas. J Horton Smith College, Northampton, Massachusetts, USA

This book presents an easy way to learn how to perform an analytical task in both SAS and R. The text provides parallel examples in SAS and R to demonstrate how to use the software and derive identical answers regardless of software choice. It also gives insight into the process of statistical coding from beginning to end by supplying worked examples of complex coding tasks. The authors include an index for each software, allowing users to easily locate procedures, and offer the SAS and R data sets and code for download online.

Simultaneous Inference in Regression

Buy the set and save! Catalog no. C7057, ISBN: 978-1-4200-7057-6 July 2009, 7 x 10, 343 pp., Suggested Price: $71.95 / £45.99 Available in eBook

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Using R for Data Management, Statistical Analysis, and Graphics Catalog no. K11360, ISBN: 978-1-4398-2755-0 July 2010, 6-1/8 x 9-1/4, 297 pp., Soft Cover Suggested Price: $59.95 / £38.99 Available in eBook

Using SAS for Data Management, Statistical Analysis, and Graphics Catalog no. K11361, ISBN: 978-1-4398-2757-4 July 2010, 6-1/8 x 9-1/4, 305 pp., Soft Cover Suggested Price: $59.95 / £38.99 Available in eBook

Statistical Analysis for Decision Makers in Healthcare Second Edition Understanding and Evaluating Critical Information in Changing Times Jeffrey C. Bauer Futures Practice, ACS Health Care Solutions, Chicago, Illinois, USA

Designed for the busy health care professional who needs to collect, analyze, and/ or evaluate data, this readily accessible work explains the fundamental concepts, uses, and misuses of statistics. Without jargon or mathematical formulas, the author introduces the practice of quantitative analysis to provide an understanding of the principles of scientific inquiry, applied to clinical medicine, program evaluation, policy analysis, management, accounting, and research. The book discusses practical scientific methods to show why statistics cannot compensate for bad science or bad data. It will help readers to intelligently evaluate the many numbers that cross their desk in the normal course of business. Catalog no. K10061, ISBN: 978-1-4398-0076-8 May 2009, 6 x 9, 160 pp., Soft Cover Suggested Price: $51.95 / £32.99 Available in eBook

Statistical Analysis of Medical Data Using SAS Geoff Der University of Glasgow, Scotland, UK

Brian S. Everitt King’s College, University of London, UK

Statistical Analysis of Medical Data Using SAS demonstrates how to use SAS to analyze medical data. Each chapter briefly describes a particular procedure but focuses on using SAS to implement it and properly interpreting the output. Step-by-step instructions, lucid explanations, clear examples, and many exercises combine to form an outstanding, self-contained guide suitable for medical researchers and statisticians alike to using SAS to analyze medical data. All of the code and data sets used in the book are available for download from the Internet. Catalog no. C469X, ISBN: 978-1-58488-469-9 September 2005, 6-1/8 x 9-1/4, 440 pp. Suggested Price: $95.95 / £60.99

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Maria L. Rizzo

Advanced Bayesian Methods for Medical Test Accuracy

Bowling Green State University, Ohio, USA Series: Chapman & Hall/CRC Computer Science & Data Analysis

Lyle D. Broemeling Broemeling and Associates, Medical Lake, Washington, USA Series: Chapman & Hall/CRC Biostatistics

This text covers the traditional core material of computational statistics, with an emphasis on using the R language via an examples-based approach. An excellent tutorial on R programming techniques used in practical computational problems, it illustrates every algorithm with at least one fully implemented example coded in R. The book also offers the source code for all examples online and contains numerous exercises. Key topics covered include the simulation of random variables from probability distributions, the visualization of multivariate data, Monte Carlo integration and variance reduction methods, Monte Carlo methods in inference, bootstrap and jackknife, MCMC methods, and density estimation.

After a review of the usual measures for assessing medical test accuracy, including specificity, sensitivity, positive predictive value, negative predictive value, and the area under the ROC curve, the book expands its scope to cover the more advanced topics of verification bias, diagnostic tests with imperfect gold standards, and medical tests where no gold standard is available. The author offers a practical treatment by including R and WinBugs code in the examples and by employing the Bayesian approach throughout the text. He also provides practical problems at the end of each chapter.

Statistical Computing with R

Catalog no. C5459, ISBN: 978-1-58488-545-0 November 2007, 6-1/8 x 9-1/4, 416 pp. Suggested Price: $88.95 / £41.99

Testing Statistical Hypotheses of Equivalence and Noninferiority Second Edition

Catalog no. K11763, ISBN: 978-1-4398-3878-5 June 2011, 6-1/8 x 9-1/4, 352 pp. Suggested Price: $129.95 / £82.00 Available in eBook

Adaptive Design Methods in Clinical Trials Shein-Chung Chow Duke University School of Medicine, Durham, North Carolina, USA

Biostatistics / Clinical Trials

Textbook

Mark Chang

Stefan Wellek Central Institute of Mental Health, Mannheim, and University of Heidelberg, Germany

AMAG Pharmaceuticals, Inc, Lexington, Massachusetts, USA Series: Chapman & Hall/CRC Biostatistics

Giving much more attention to noninferiority testing, this second edition provides readers with a rich repertoire of efficient solutions to specific equivalence and noninferiority testing problems frequently encountered in the analysis of real data sets. It also includes new chapters on equivalence tests for multivariate data and tests for relevant differences between treatments. Drawing from real-life medical research, the author uses numerous examples throughout to illustrate the methods. Updated computer programs in SAS, Fortran, and R for facilitating the routine application of testing procedures are available online at www.crcpress. com.

Adaptive Design Methods Clinical Trials presents the principles and methodologies in adaptive design and analysis that pertain to adaptations made to trial or statistical procedures based on accrued data of ongoing clinical trials. The book also offers a well-balanced summary of current regulatory perspectives, recently developed statistical methods, and practical guidelines for choosing an optimal design. Providing a broad range of adaptive design methods that use both analytical and simulation approaches, this resource fills the need for a unified, comprehensive, and updated book in the clinical research and development of adaptive design and analysis.

Catalog no. K10408, ISBN: 978-1-4398-0818-4 June 2010, 6-1/8 x 9-1/4, 431 pp. Suggested Price: $99.95 / £63.99

Catalog no. C7761, ISBN: 978-1-58488-776-8 November 2006, 6 x 9, 296 pp. Suggested Price: $94.95 / £63.99

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Time Series Modeling of Neuroscience Data Tohru Ozaki

Bayesian Adaptive Methods for Clinical Trials Scott M. Berry, Bradley P. Carlin, J. Jack Lee, and Peter Muller

Inst.Statistical Mathematics & Graduate Univ. of Adv. Studies

Series: Chapman & Hall/CRC Biostatistics

There is increasing interest in the use of time series models for the study of neuroscience data such as EEG, MEG, fMRI, and NIRS. Written by one of the pioneers of these methods, this book presents an overview of time series models for the study of neuroscience data. It is accessible to applied statisticians working with neuroscience data as well as quantitatively trained neuroscientists. The book is supported by many real examples to illustrate the methods and provides a computational toolbox on the web, which enables readers to apply the methods to real data.

This book explores the growing role of Bayesian thinking in clinical trial analysis. Covering Phase I, II, and III clinical trials, it establishes the basic principles before extending them to specific phases and endpoints. The authors also discuss special topics that span different phases of the process, including the use of historical data, equivalence studies, multiplicity and multiple comparisons, and subgroup analysis. They provide many detailed examples drawing on real data sets. Along with other materials, the R and WinBUGS codes used throughout are available on supporting websites.

Catalog no. C4602, ISBN: 978-1-4200-9460-2 June 2011, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $99.95 / £63.99

Catalog no. K11217, ISBN: 978-1-4398-2548-8 July 2010, 6-1/8 x 9-1/4, 323 pp. Suggested Price: $89.95 / £57.99

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Controversial Issues in Clinical Trials

Clinical Trials

Shein-Chung Chow

Second Edition

Duke University School of Medicine, Durham, North Carolina, USA Chapman & Hall/CRC Biostatistics Series

Diane L. Fairclough University of Colorado Health Sciences Center, Denver, USA Series: Chapman & Hall/CRC Interdisciplinary Statistics

Covering a number of controversial issues that are commonly encountered when conducting clinical trials, this book serves as a useful desk reference and an assessment of the current state of the art. It discusses the appropriateness of traditional statistical hypotheses (which primarily focus on efficacy) for clinical evaluation of both efficacy and safety, instability of classical sample size calculation based on information from a small pilot study, and integrity of randomization and blinding. The author illustrates the issues using real-world examples and upto-date data. He also provides recommendations of possible resolutions of these issues.

Using SAS, SPSS, and R, this book addresses design and analysis aspects in enough detail so that readers can apply statistical methods to their own longitudinal studies. This edition includes a new chapter on testing models that involve moderation and mediation, a new chapter on QALYs and QTWiST specific to clinical trials, and recent methodological developments for the analysis of trials with missing data. It also presents revised discussions of multiple comparisons procedures that focus on the integration of HRQoL outcomes with other study outcomes using gatekeeper strategies. Data sets, examples, applications, and SAS, R, and SPSS code are available on the book’s website.

Catalog no. K12247, ISBN: 978-1-4398-4961-3 June 2011, 6-1/8 x 9-1/4, 576 pp. Suggested Price: $99.95 / £63.99

Catalog no. C6117, ISBN: 978-1-4200-6117-8 January 2010, 6-1/8 x 9-1/4, 424 pp. Suggested Price: $89.95 / £57.99

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Data and Safety Monitoring Committees in Clinical Trials

Edited by

Jay Herson John Hopkins University, Baltimore, Maryland, USA Series: Chapman & Hall/CRC Biostatistics

Design and Analysis of Quality of Life Studies in Clinical Trials

Handbook of Adaptive Designs in Pharmaceutical and Clinical Development Annpey Pong Merck Research Laboratories, Rahway, New Jersey, USA

Shein-Chung Chow Duke University School of Medicine, Durham, North Carolina, USA

Focusing on the practical clinical and statistical issues that arise in pharmaceutical industry trials, this book summarizes the author’s experience in serving on many DMCs and in heading up a contract research organization that provided statistical support to nearly seventy-five DMCs. It explains the difference in DMC operations between the pharmaceutical industry and NIH-sponsored trials. Leading you through the types of reports for adverse events and lab values, the author presents the statistical requirements of data monitoring committees and gives advice on how statisticians can best interact with physician members of these committees.

This handbook provides a comprehensive and unified presentation of the principles and latest statistical methodologies used when modifying trial procedures based on accrued data of ongoing clinical trials. The book also gives a well-balanced summary of current regulatory perspectives and presents realworld examples of a range of adaptive designs. Leading clinical researchers in the pharmaceutical industry, academia, and regulatory agencies examine issues commonly encountered when applying adaptive design methods in clinical trials. They discuss the importance of sample size estimation/allocation, justification, and adjustment when implementing a complicated adaptive design.

Catalog no. C7037, ISBN: 978-1-4200-7037-8 March 2009, 6-1/8 x 9-1/4, 191 pp. Suggested Price: $89.95 / £57.99

Catalog no. K10507, ISBN: 978-1-4398-1016-3 October 2010, 7 x 10, 496 pp. Suggested Price: $99.95 / £63.99

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Design and Analysis of Clinical Trials with Time-to-Event Endpoints

Textbook

Karl E. Peace

Introduction to Statistical Methods for Clinical Trials

Jiann-Ping Hsu College of Public Health, Georgia Southern University, Statesboro, USA Series: Chapman & Hall/CRC Biostatistics

Thomas D. Cook and David L. DeMets University of Wisconsin, Madison, USA Series: Chapman & Hall/CRC Texts in Statistical Science

This resource provides a thorough presentation of the design, monitoring, analysis, and interpretation of clinical trials in which time-to-event is of critical interest. Incorporating the collaborations of truly world-class statisticians, it discusses the design and monitoring of Phase II and III clinical trials with timeto-event endpoints. The book presents parametric, semiparametric, categorical, and Bayesian inferential and descriptive methods for analyzing time-to-event endpoints and covers numerous clinical trial applications, including analgesic, antibiotic, antiviral, cancer and cardiovascular prevention, optimal assignment of treatments, adverse events, and carcinogenicity.

This text provides a solid understanding of the various statistical topics relevant to the design, monitoring, and analysis of a clinical trial. It covers basic experimental design, sample size, randomization procedures, interim and survival analyses, quality of life assessment, and longitudinal methods. The book describes all phases of a clinical trial and explores the advantages of and objections to the intent-to-treat principle as well as its implementation. With exercises at the end of most chapters, it also illustrates methods using examples with real data from a variety of disease areas, including heart and lung diseases, cancer, and AIDS.

Edited by

Catalog no. C6639, ISBN: 978-1-4200-6639-5 April 2009, 6-1/8 x 9-1/4, 616 pp. Suggested Price: $99.95 / £63.99

Catalog no. C0005, ISBN: 978-1-58488-027-1 November 2007, 8-1/2 x 11, 464 pp. Suggested Price: $77.95 / £49.99

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Second Edition

Sample Sizes for Clinical Trials

Susanne Prokscha

Steven A. Julious

Redwood City, California, USA

University of Sheffield, England, UK

Practical Guide to Clinical Data Management, Second Edition provides a solid introduction to the key process elements of clinical data management. It incorporates the modifications that data management groups have made under 21 CFR 11 and examines the differences in data management between EDCbased studies and paper-based studies. The book has been reorganized into three sections. Part I covers the basic data management tasks. Part II addresses the expectations of the FDA and auditors for how data management groups carry out their work in compliance with regulations. Part III focuses on the computer systems.

With worked examples and problems based on real-world scenarios, this book takes readers through the process of calculating the sample size for many types of clinical trials. It covers the most common types of clinical trials across all phases. The author discusses how assumptions made in a sample size calculation can impact the calculation. He provides calculations for many of the trials and offers hints and tips on how to optimize the calculations. He also illustrates the steps involved in determining sample size, from defining the trial objective to selecting an appropriate endpoint.

Catalog no. 7615, ISBN: 978-0-8493-7615-3 August 2006, 6-1/8 x 9-1/4, 252 pp. Suggested Price: $179.95 / £114.00

Catalog no. C7397, ISBN: 978-1-58488-739-3 August 2009, 6-1/8 x 9-1/4, 317 pp. Suggested Price: $82.95 / £49.99 Available in eBook

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Randomized Clinical Trials of Nonpharmacologic Treatments Edited by

Isabelle Boutron and Philippe Ravaud

Textbook

Epidemiology Study Design and Data Analysis, Second Edition

INSERM U738, Paris, France

Mark Woodward

David Moher

Mount Sinai Medical Centre, New York, USA Series: Chapman & Hall/CRC Texts in Statistical Science

University of Ottawa, Ontario, Canada Series: Chapman & Hall/CRC Biostatistics

Nonpharmacological treatments include a wide variety of treatments such as surgery, technical procedures, implantable devices, nonimplantable devices, rehabilitation, psychoteherapy, and behavioral interventions. This book focuses on the methods of assessing nonpharmacological treatments, highlighting specific issues and discussing all possible designs of trials. It provides practical examples to underline the issues and solutions in assessing nonpharmacological treatment in trials. Arguably the first book to exclusively explore this topic, it discusses various categories of treatments from surgical procedures to psychotherapy.

Discussing techniques used in report writing, models for diagnostics, and design issues, this book covers the spectrum of statistical principles and analytical tools used in epidemiological research. This second edition includes new material on systematic evaluation, meta-analysis, regression dilution, case-cohort studies, case-crossover studies, pooled logistic regression, and a companion Web site containing data sets for examples and exercises, SAS and Stata code for examples, a sample size calculator, and a SAS floating absolute risk macro. The author favors the use of basic mathematics and practical methods over complicated mathematical proofs, making the book comprehensive, yet accessible.

Catalog no. C8017, ISBN: 978-1-4200-8801-4 June 2011, 6-1/8 x 9-1/4, 300 pp. Suggested Price: $99.95 / £63.99

Catalog no. C415X, ISBN: 978-1-58488-415-6 November 2004, 6-1/8 x 9-1/4, 872 pp. Suggested Price: $99.95 / £49.99

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Sample Size Calculations in Clinical Research

Forensic Epidemiology

Second Edition N-Solution bundle version

Point Park University, Pittsburgh, Pennsylvania, USA

Edited by

Shein-Chung Chow, Jun Shao, and Hansheng Wang

Steven A. Koehler Peggy A. Brown

Series: Chapman & Hall/CRC Biostatistics

Pittsburgh, Pennsylvania, USA Series: International Forensic Science and Investigation

This book explains how the formulas and procedures for sample size calculations can be used in a variety of clinical research and development stages. It presents real-world examples from several therapeutic areas and explores emerging topics in pharmaceutical research and development. This edition now provides sample size calculations for dose response studies, microarray studies, and Bayesian approaches. It also includes a basic version of PharmaSoftware Solutions, Inc.’s N Solution 2007. Along with sensitivity analyses for each procedure, the software contains all procedures for testing equality, superiority/noninferiority, and equivalence for comparing means, proportions, and time-to-event data.

Forensic epidemiology provides an investigative response to public health issues and events that may be linked to criminal activities. It is a leading tool of investigation, partnering public health officers with law enforcement like never before. This book demonstrates the important role of forensic epidemiology in public health, the medical community, and the legal system. Emphasizing the importance of understanding the terminology and procedures of each field in order to work together effectively, the text explains methods to collect, analyze, and interpret data for criminal investigations using a variety of illustrations and real-world case studies.

Catalog no. K10700, ISBN: 978-1-4398-1359-1 March 2009, 6-1/8 x 9-1/4, 480 pp., Pack - Book and CD Suggested Price: $249.95 / £159.00

Catalog no. 63278, ISBN: 978-1-4200-6327-1 August 2009, 6-1/8 x 9-1/4, 320 pp. Suggested Price: $133.95 / £85.00 Available in eBook

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Clinical Trials / Epidemiology

Practical Guide to Clinical Data Management

Handbook of Spatial Statistics Edited by

Epidemiology / Mathematics for Biology & Medicine 88

Alan E. Gelfand, Peter J. Diggle, Montserrat Fuentes, and Peter Guttorp

Textbook

Veterinary Clinical Epidemiology Third Edition

Series: Chapman & Hall/CRC Handbooks of Modern Statistical Methods

Ronald D. Smith

Based on the work of prominent researchers, this book provides broad, thorough coverage, from historical to contemporary topics. It explores the modeling advances, computational approaches, and new methodologies that have emerged in recent years. The handbook focuses on continuous and discrete spatial variation, spatial point patterns, and spatio-temporal processes. It also covers multivariate spatial process models, spatial aggregation, spatial misalignment, and spatial gradients in depth. The theory and applications are illustrated with many real-world data examples.

Veterinary Clinical Epidemiology, Third Edition serves as a teaching resource and a reference on the application of epidemiologic methods in veterinary clinical research. The third edition continues its focus on observations of naturally or spontaneously occurring diseases. This well-illustrated text includes discussion of applications of epidemiology in medical decision making at the individual and herd levels, details the relevance of epidemiology to companion animal, food animal, and population medicine; and describes applications of molecular diagnostic tools and advanced statistical techniques. It includes many case studies and examples from veterinary literature.

Catalog no. C7287, ISBN: 978-1-4200-7287-7 March 2010, 7 x 10, 619 pp. Suggested Price: $99.95 / £63.99 Available in eBook

Statistical Thinking in Epidemiology

University of Illinois College of Veterinary Medicine, USA

Catalog no. 1566, ISBN: 978-0-8493-1566-4 September 2005, 7 x 10, 280 pp. Suggested Price: $115.95 / £73.85

Applications of Lie Groups to Difference Equations Vladimir Dorodnitsyn

University of Leeds, UK

Keldysh Institute of Applied Mathematics, Moscow, Russia Series: Differential and Integral Equations and Their Applications

Addressing issues that have plagued researchers throughout the last decade, this book provides new insights into the many existing problems in statistical modeling and offers several alternative strategies to approach these problems. Emphasizing the importance of statistical thinking behind all analyses, the authors use specific examples in epidemiology to illustrate different model specifications that can imply different sets of causal relationships between variables. Each model is interpreted with regard to the context of implicit or explicit causal relationships. The authors also use vector geometry where applicable to provide an intuitive understanding of important statistical concepts.

Applications of Lie Groups to Difference Equations is the first book to provide a systematic construction of invariant difference schemes for nonlinear differential equations. A guide to methods and results in a new area of application of Lie groups to difference equations, difference meshes (lattices), and difference functionals, this book focuses on the preservation of complete symmetry of original differential equations in numerical schemes. This symmetry preservation results in symmetry reduction of the difference model along with that of the original partial differential equations and in order reduction for ordinary difference equations.

Catalog no. K10018, ISBN: 978-1-4200-9991-1 May 2011, 6-1/8 x 9-1/4, 256 pp. Suggested Price: $89.95 / £57.99

Catalog no. C3090, ISBN: 978-1-4200-8309-5 December 2010, 7 x 10, 344 pp. Suggested Price: $89.95 / £57.99

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Yu-Kang Tu and Mark S. Gilthorpe

Textbook

Biological Computation Textbook

Ehud Lamm

Statistics for Epidemiology

Tel-Aviv University, Israel

Nicholas P. Jewell

Ron Unger

University of California, Berkeley, USA Series: Chapman & Hall/CRC Texts in Statistical Science

Bar-Ilan University, Ramat-Gan, Israel Series: Chapman & Hall/CRC Mathematical & Computational Biology

Statistics for Epidemiology fills a substantial niche by explaining the ideas behind the analysis of epidemiological data without requiring a high level of mathematics or resorting to a “cookbook” format. It covers the basic material for analyzing data that arise from simple epidemiological studies, including case-control and matched studies. Methodologically, it describes stratification techniques for handling confounding and interaction and the logistic regression model. The author uses a case-study approach, following a few simple examples through several method chapters rather than introducing a different example at each stage.

A unified overview of computer science ideas inspired by biology, Biological Computation presents the most fundamental and significant concepts in this area. In the book, readers discover profound ideas about computer science through biological examples, such as the use of DNA for performing computations and how evolution solves optimization problems. The text focuses on cellular automata, evolutionary computation, neural networks, and molecular computation. Each chapter explores the biological background, describes the computational techniques, gives examples of applications, discusses possible variants of the techniques, and includes exercises and solutions.

Catalog no. C4339, ISBN: 978-1-58488-433-0 August 2003, 6-1/8 x 9-1/4, 352 pp. Suggested Price: $89.95 / £56.99

Catalog no. C7959, ISBN: 978-1-4200-8795-6 January 2011, 6-1/8 x 9-1/4, 344 pp. Suggested Price: $79.95 / £49.99

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Textbook

From Single Scale-Based Models to Multiscale Modeling Edited by

An Introduction to Stochastic Processes with Applications to Biology

Arnaud Chauvière, Luigi Preziosi, and Claude Verdier

Second Edition

Series: Chapman & Hall/CRC Mathematical & Computational Biology

Linda J. S. Allen

This book brings together mechanical, mathematical, physical, and biological approaches for simulating the behavior of cells, specifically tumor cells. It illustrates how phenomena occurring at various scales can be modeled and coupled to account for multiscale aspects. The text discusses experimental and theoretical topics, including biological and complex modeling issues. It links subcellular effects to cellular properties, covers the modeling of cell migration and multicellular systems, and examines cell interactions with the environment, such as the rolling motion of leukocytes on a vessel wall and the forces exerted by cells on a rigid substrate.

Focusing on discrete and continuous time Markov chains and continuous time and state Markov processes, this text presents the basic theory of stochastic processes necessary in understanding and applying stochastic methods to biological problems. This edition contains a new chapter on stochastic differential equations that extends the basic theory to multivariate processes. Along with additional references, it now includes examples and exercises from cellular and molecular biology and doubles the number of exercises and MATLAB® programs at the end of each chapter.

Catalog no. C4548, ISBN: 978-1-4200-9454-1 January 2010, 6-1/8 x 9-1/4, 482 pp. Suggested Price: $119.95 / £76.99

Texas Tech University, Lubbock, USA

Catalog no. K10993, ISBN: 978-1-4398-1882-4 December 2010, 6-1/8 x 9-1/4, 490 pp. Suggested Price: $89.95 / £39.99

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Differential Equations and Mathematical Biology Second Edition D.S. Jones, Michael Plank, and B.D. Sleeman Series: Chapman & Hall/CRC Mathematical & Computational Biology

Ideal for courses on differential equations with applications to mathematical biology or as an introduction to mathematical biology, this best-selling text introduces the fundamental modeling and analytical techniques used to understand biological phenomena. It discusses the modeling of biological behavior, including the heartbeat cycle, chemical reactions, nerve pulses, predator–prey models, and epidemics. This expanded edition includes a new section on spiral waves, recent developments in tumor biology, and additional examples and exercises. It also offers more on the numerical solution of differential equations and numerical bifurcation analysis, providing downloadable MATLAB® files online. Catalog no. C8357, ISBN: 978-1-4200-8357-6 November 2009, 6-1/8 x 9-1/4, 462 pp. Suggested Price: $82.95 / £35.99

An Introduction to Systems Biology Design Principles of Biological Circuits Uri Alon Weizmann Institute of Science, Rehovot, Israel Series: Chapman & Hall/CRC Mathematical & Computational Biology

This book presents design principles that govern the structure and behavior of biological networks such as gene circuits, highlighting simple, recurring circuit elements that make up the network. It provides a quantitative theory for which circuits are found in a given environment and a mathematical framework for understanding and even designing biological circuits. The book requires only basic mathematics and includes a review of the necessary background material. It fills need for a comprehensive introduction to the concepts, principles, and mathematical tools that will form the basis of future developments in the field. Catalog no. C6420, ISBN: 978-1-58488-642-6 July 2006, 7 x 10, 320 pp., Soft Cover Suggested Price: $59.95 / £37.99

Textbook Textbook

Dynamical Models in Medicine Yang Kuang and John Nagy

Mathematics for Biology & Medicine

Cell Mechanics

Mathematical and Experimental Modeling of Physical and Biological Processes H.T. Banks and H.T. Tran

Series: Chapman & Hall/CRC Mathematical & Computational Biology

North Carolina State University, Raleigh, USA Series: Textbooks in Mathematics

This self-contained book focuses on three categories of disease: cancer, viral diseases, and dynamical diseases. It presents the medical and biological background of the diseases, specific issues to be modeled, and existing methods and their limitations. The text also introduces mathematical and programming tools, along with analytical and numerical studies of the models. It provides exercises and projects at the end of most chapters, hints and answers to selected problems at the back of the book, and a supplementary website with lecture notes, homework problems, useful computer programs, and other reference material.

Exploring how mathematics is applied to problems in science and engineering, this book discusses mathematical modeling in the context of case study problems that arise in industry and government laboratories. It covers thermal imaging and detection, dynamic properties of beams, acoustics and fluid transport, and size-structured population dynamics for marine populations. The text explains physical and biological relationships and mechanisms through a first principlesbased fundamental modeling approach. It also emphasizes model validation through specific laboratory experiments as well as data collection and analysis.

Catalog no. C990X, ISBN: 978-1-58488-990-8 May 2011, 6-1/8 x 9-1/4 Suggested Price: $79.95 / £49.99

Catalog no. C7337, ISBN: 978-1-4200-7337-9 January 2009, 6-1/8 x 9-1/4, 298 pp. Suggested Price: $82.95 / £49.99

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Multiscale Cancer Modeling Edited by

Thomas S. Deisboeck Massachusetts General Hospital and Harvard Medical School, Boston, USA

Georgios S. Stamatakos

Mathematics for Biology & Medicine

Institute of Communication and Computer Systems, National Technical University of Athens, Greece Series: Chapman & Hall/CRC Mathematical & Computational Biology

Multiscale Cancer Modeling discusses the scientific and technical expertise necessary to conduct innovative cancer modeling research across scales. It presents modeling methods and results at the forefront of cancer simulation at all levels of biocomplexity and explains how combinations of multilevel cancer models can enhance our understanding of cancer and can help optimize its treatment. The book explores computational cancer research ranging from experimentally testable hypothesis generation and cross-scale data integration to patient-specific prediction of progression and treatment planning. ÂŽ Catalog no. K10739, ISBN: 978-1-4398-1440-6 December 2010, 6-1/8 x 9-1/4, 384 pp. Suggested Price: $89.95 / ÂŁ57.99 Available in eBook

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Artificial Neural Networks in Biological and Environmental Analysis.............................................................................74

Biological and Biomedical Coatings Handbook: Applications......................................................................38

Atlas of Fish Histology........................................................9

Biological and Biomedical Coatings Handbook: Processing and Characterization.........................................................38

Atlas of Human Central Nervous System Development 5 Volume Set.......................................................................4

Accuracy and Reliability of Statistical Classification: Advanced ROC Analysis...................................................74

Atlas of Immunology, Third Edition...................................8

Biological Computation....................................................88

Atlas of the Neonatal Rat Brain.........................................20

Biological Data Mining.....................................................76

Augmenting Cognition.....................................................20

Biological Sequence Analysis Using the SeqAn C++ Library......................................................................70

Adaptive Design Methods in Clinical Trials......................85 Adaptive Motion Compensation in Radiotherapy.............49 Adhesion Molecules..........................................................54 Adipose Tissue and Inflammation.....................................24 Advanced Bayesian Methods for Medical Test Accuracy....85 Advanced Electroporation Techniques in Biology and Medicine...........................................................................42 Advanced Nutrition: Macronutrients, Micronutrients, and Metabolism.......................................................................24 Advanced Signal Processing: Theory and Implementation for Sonar, Radar, and Non-Invasive Medical Diagnostic Systems, Second Edition...................................................49

Autism: Oxidative Stress, Inflammation, and Immune Abnormalities....................................................................20

Biological Clock in Fish......................................................5

Reproduction of Amphibians..............................................5

Automated EEG-Based Diagnosis of Neurological Disorders: Inventing the Future of Neurology...................20

Biologically Inspired Robotics...........................................43

Automated Image Detection of Retinal Pathology.............49

Biology for Engineers........................................................43

Biomaterials and Regenerative Medicine in Ophthalmology.................................................................38

Basic Introduction to Bioelectromagnetics, Second Edition..................................................................42

Biomaterials and Tissue Engineering in Urology...............38

Basic Organometallic Chemistry: Concepts, Syntheses, and Applications of Transition Metals......................................33

Biomaterials: A Nano Approach........................................60

Biologically Inspired Textiles.............................................38

Biomaterials for Treating Skin Loss...................................38 Biomedical Composites.....................................................39

Advanced Textiles for Wound Care...................................37

Basic Pharmacokinetics.....................................................68

Advances in Chromatographic Techniques for Therapeutic Drug Monitoring..............................................................63

Basic Pharmacology: Understanding Drug Actions and Reactions...........................................................................67

Biomedical Microsystems..................................................43

Advances in Chromatography, Volume 47........................58

Basic Statistics and Pharmaceutical Statistical Applications, Second Edition..................................................................75

Biomedical Sensors and Instruments, Second Edition.......43 Biomedical Technology and Devices Handbook................44 BioMEMS: Science and Engineering Perspectives.............70

Advances in Food Biochemistry........................................33

Basic Transport Phenomena in Biomedical Engineering, 2nd Edition.......................................................................42

Advances in Food Dehydration.........................................12

Bayesian Adaptive Methods for Clinical Trials...................85

Biomolecular EPR Spectroscopy.......................................34

Advances in the Neuroscience of Addiction.......................19

Bayesian Analysis for Population Ecology..........................75

Bionanotechnology...........................................................44

Airway Chemoreceptors in the Vertebrates..........................4

Bayesian Analysis Made Simple: An Excel GUI for WinBUGS........................................................................75

Bionanotechnology II: Global Prospects............................44

Advances in Chromatography, Volume 48........................58 Advances in Chromatography: Volume 49........................58

Algorithms in Bioinformatics: A Practical Introduction....69 An Introduction to Generalized Linear Models, Third Edition....................................................................80 An Introduction to Microscopy.........................................59 An Introduction to Stata for Health Researchers, Third Edition....................................................................80 An Introduction to Stochastic Processes with Applications to Biology, Second Edition....................................................89 An Introduction to Survival Analysis Using Stata, Third Edition....................................................................81 An Introduction to Systems Biology: Design Principles of Biological Circuits.............................................................89 Analysis of Pesticides in Food and Environmental Samples.............................................................................13 Analysis of Questionnaire Data with R.............................74 Animal Clinical Chemistry: A Practical Handbook for Toxicologists and Biomedical Researchers, Second Edition....................................................................9 Apoptosis: Modern Insights into Disease from Molecules to Man....................................................................................3 Application of Solution Protein Chemistry to Biotechnology...................................................................33

Bayesian Disease Mapping: Hierarchical Modeling in Spatial Epidemiology....................................................................75

Biopharmaceuticals in Plants: Toward the Next Century of Medicine...........................................................................63 Biosensors in Food Processing, Safety, and Quality Control................................................................13 Biosignal and Medical Image Processing, Second Edition.49

Bayesian Methods for Data Analysis, Third Edition..........75

Biostatistics: A Computing Approach...............................76

Bayesian Methods: A Social and Behavioral Sciences Approach, Second Edition................................................76

Biotechnology in Functional Foods and Nutraceuticals.....25

Bayesian Modeling in Bioinformatics................................69 Bioactive Foods and Extracts: Cancer Treatment and Prevention.........................................................................25 Bioactive Natural Products: Detection, Isolation, and Structural Determination, Second Edition........................34

Biotechnology Operations: Principles and Practices..........54 Biotechnology: A Comprehensive Training Guide for the Biotechnology Industry.....................................................54 Bone Repair Biomaterials..................................................39 Boron Science: New Technologies and Applications..........55

Bioactive Peptides..............................................................67

Bioactive Peptides: Applications for Improving Nutrition and Health........................................................................25

Cancer Epigenetics............................................................18

Biobased Surfactants and Detergents: Synthesis, Properties, and Applications...............................................................37 Biocatalysis and Agricultural Biotechnology......................54 Biochemical Applications of Nonlinear Optical Spectroscopy.....................................................................34 Biofluid Mechanics: The Human Circulation...................42 Bioinformatics Database Systems......................................70

Applied Biomedical Microbiology: A Biofilms Approach.........................................................13

Bioinformatics: High Performance Parallel Computer Architectures.....................................................................70

Applied Categorical and Count Data Analysis...................74

Biointegration of Medical Implant Materials: Science and Design...............................................................................37

Approaches to the Conformational Analysis of Biopharmaceuticals...........................................................64

Biomimetics: Biologically Inspired Technologies...............44

Bayesian Ideas and Data Analysis: An Introduction for Scientists and Statisticians.................................................75

Applications of Lie Groups to Difference Equations.........88

Applied Optics Fundamentals and Device Applications: Nano, MOEMS, and Biotechnology.................................54

Biomedical Engineering Principles, Second Edition..........43

Biological and Biomedical Coatings Handbook, Two-Volume Set................................................................38

Title Index

3D Cell-Based Biosensors in Drug Discovery Programs: Microtissue Engineering for High Throughput Screening..........................................................................57

Cancer Systems Biology....................................................70 Carotenoids: Physical, Chemical, and Biological Functions and Properties...................................................................34 Case Studies in Physiology and Nutrition.........................25 Cell Culture Technology for Pharmaceutical and Cell-Based Therapies..........................................................................63 Cell Mechanics: From Single Scale-Based Models to Multiscale Modeling.........................................................89 Cellular and Molecular Biology of Metals...........................3 Cellular Response to Biomaterials.....................................39 Cereal Grains: Properties, Processing, and Nutritional Attributes..........................................................................25 Chemical and Biological Properties of Food Allergens.........8 Chemical Physics: Electrons and Excitations.....................52

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Design of Experiments: An Introduction Based on Linear Models..............................................................................77

Chemistry of Natural Products: A Unified Approach, Second Edition..................................................................67

Development and Application of Biomarkers....................35

Fat Detection: Taste, Texture, and Post Ingestive Effects....21

Development of Non-teleost Fishes.....................................5

Fatty Acids in Health Promotion and Disease Causation...26

Chiral Recognition in the Gas Phase.................................52

Feedback Control in Systems Biology...............................71

Chiral Separations by Capillary Electrophoresis................58

Dictionary of Alkaloids, Second Edition with CD-ROM.........................................................................67

Chirality in Biological Nanospaces: Reactions in Active Sites........................................................................35

Dictionary of Marine Natural Products with CD-ROM.........................................................................64

Chitin, Chitosan, Oligosaccharides and Their Derivatives: Biological Activities and Applications................................35

Differential Equations and Mathematical Biology, Second Edition..................................................................89

A First Course in Linear Model Theory.............................78

Choice-Based Conjoint Analysis: Models and Designs......76

Diffuse Optical Tomography: Principles and Applications......................................................................50

Fish Defenses Vol. 2: Pathogens, Parasites and Predators.....6

Digital Microfluidic Biochips: Design Automation and Optimization....................................................................55

FLIM Microscopy in Biology and Medicine.....................52

Chemistry for the Life Sciences, Second Edition...............34 Chemistry of Biomolecules...............................................34

Cleaning Validation Manual: A Comprehensive Guide for the Pharmaceutical and Biotechnology Industries.............62 Clinical Procedures for Medical Technology Specialists.....44 Clinical Trial Data Analysis Using R.................................76

Title Index

Cluster Randomised Trials................................................76 Clustering in Bioinformatics and Drug Discovery.............77 Colloids in Biotechnology.................................................55 Colloids in Drug Delivery.................................................64 A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis........................................................................9 Combinatorial Pattern Matching Algorithms in Computational Biology Using Perl and R.........................70

Drug Delivery and Targeting: For Pharmacists and Pharmaceutical Scientists..................................................68 Drug Delivery Systems, Third Edition..............................67 Drug Device Combination Products: Delivery Technologies and Applications...............................................................64 Drugs of Natural Origin: A Treatise of Pharmacognosy, Sixth Revised Edition........................................................65 Dynamical Models in Medicine........................................89

Comparative High Pressure Biology....................................5

Computational Hydrodynamics of Capsules and Biological Cells..................................................................................44

Electronics for Radiation Detection..................................50

Computational Intelligence in Medical Imaging: Techniques and Applications...............................................................49 Computational Protein-Protein Interactions.....................30 Computer Vision: From Surfaces to 3D Objects...............49

Dose Finding by the Continual Reassessment Method......77

Emerging Protein Biotherapeutics.....................................30 Encyclopedia of Agricultural, Food, and Biological Engineering, Second Edition - 2 Volume Set (Print Version)...................................................................55

A Concise Guide to Intraoperative Monitoring.................45

Encyclopedia of Biotechnology in Agriculture and Food (Print Version)...................................................................55

Concussive Brain Trauma: Neurobehavioral Impairment & Maladaptation, Second Edition.........................................20

Encyclopedia of Chromatography, Third Edition (Print Version)...................................................................58

Controversial Issues in Clinical Trials................................86

Endocrine Disruption Modeling.......................................31

Copper Amine Oxidases: Structures, Catalytic Mechanisms and Role in Pathophysiology.............................................35

Engineering Genetic Circuits............................................52

Correction Techniques in Emission Tomographic Imaging.............................................................................50

Environmental Effects on Seafood Availability, Safety, and Quality..............................................................................32

Covariance Modelling.......................................................77 CRC Desk Reference for Nutrition, Third Edition...........25 CRC Handbook of Chemistry and Physics, 92nd Edition.....................................................................62

D Data and Safety Monitoring Committees in Clinical Trials....................................................................86 Data Mining in Biomedical Imaging, Signaling, and Systems.............................................................................71 Defensive Mutualism in Microbial Symbiosis....................13 Dermatokinetics of Therapeutic Agents............................67 Design and Analysis of Clinical Trials with Time-to-Event Endpoints.........................................................................86 Design and Analysis of Experiments with SAS..................77 Design and Analysis of Quality of Life Studies in Clinical Trials, Second Edition.......................................................86 Design Controls for the Medical Device Industry.............45 Design of Biomedical Devices and Systems Second Edition..................................................................45

Environmental Biotechnology...........................................13

Environmental Microbiology for Engineers.......................55 Epidemiology: Study Design and Data Analysis, Second Edition..................................................................87 Epigenetics in Biology and Medicine.................................18 Epilepsy: Mechanisms, Models, and Translational Perspectives.......................................................................20 Epilepsy: The Intersection of Neurosciences, Biology, Mathematics, Engineering and Physics..............................21 Epileptic Seizures and the EEG: Measurement, Models, Detection and Prediction..................................................21

Fermentation Microbiology and Biotechnology, Third Edition..............................................................................14 Fire Toxicity......................................................................32 Fish Defenses Vol. 1: Immunology......................................6 Fish Locomotion: An Eco-ethological Perspective...............6 Flow Cyclometry: A Practical Guide.................................19 Food Constituents and Oral Health: Current Status and Future Prospects................................................................26 Food Lipids: Chemistry, Nutrition, and Biotechnology, Third Edition....................................................................26 Foodborne Pathogens: Hazards, Risk Analysis and Control, 2nd Edition.......................................................................14 Forensic Epidemiology......................................................87 Frailty Models in Survival Analysis....................................78 Freeze-drying of Pharmaceutical and Food Products.........14 Functional Foods: Principles and Technology....................26 Fundamental Food Microbiology, Fourth Edition.............14 Fundamentals of Microfluidics and Lab on a Chip for Biological Analysis and Discovery ....................................56 Fundamentals of Nanotechnology.....................................61 Fungal Pathogenesis in Plants and Crops: Molecular Biology and Host Defense Mechanisms, Second Edition...............14

G Gaussian Process Regression Analysis for Functional Data................................................................78 Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, Third Edition.....................................................3 Gene Biotechnology, Third Edition..................................56 Gene Expression Studies Using Affymetrix Microarrays....71 Generalized Additive Models: An Introduction with R.....78 Generalized Latent Variable Modeling: Multilevel, Longitudinal, and Structural Equation Models.................79 Generalized Linear Models and Extensions, Second Edition..................................................................79 Genetics and Randomness................................................71 Geomicrobiology..............................................................14 Geomicrobiology, Fifth Edition........................................15 Glycome Informatics: Methods and Applications..............71

Ergonomics for Rehabilitation Professionals......................45

Gonorynchiformes and Ostariophysan Relationships: A Comprehensive Review....................................................6

Essentials of Law and Ethics for Pharmacy Technicians, Third Edition....................................................................68

Guide to Microbiological Control in Pharmaceuticals and Medical Devices, Second Edition......................................15

Exercises and Solutions in Biostatistical Theory................77

Experimental Surgical Models in the Laboratory Rat........10 Exploratory Multivariate Analysis by Example Using R.....78 Extending the Linear Model with R: Generalized Linear, Mixed Effects and Nonparametric Regression Models.......78

Handbook of Adaptive Designs in Pharmaceutical and Clinical Development.......................................................86 Handbook of Analysis of Oligonucleotides and Related Products............................................................................56 Handbook of Analytical Validation...................................65

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Human Variation: From the Laboratory to the Field...........6

Handbook of Aqueous Solubility Data, Second Edition....35

Hydrophilic Interaction Liquid Chromatography (HILIC) and Advanced Applications...............................................65

Key Transitions in Animal Evolution...................................6

Handbook of Biochemistry and Molecular Biology, Fourth Edition - CD-ROM Version..................................36

Hyphenated and Alternative Methods of Detection in Chromatography...............................................................59

Knowledge-Driven Medicine: A Machine Learning Approach..........................................................................51

Handbook of Biological Effects of Electromagnetic Fields, Third Edition - 2 Volume Set............................................45

Handbook of Biomedical Optics.......................................46

Illustrated Dictionary of Biotechnology............................56

Handbook of Chemoinformatics Algorithms....................71

Illustrated Dictionary of Immunology, Third Edition.........8

Laboratory Animal Pocket Reference Series: 12- Volume Set.................................................................11

Handbook of Cryo-Preparation Methods for Electron Microscopy.......................................................................58

Image Processing in Radiation Therapy.............................50

Handbook of Fermented Functional Foods, Second Edition..................................................................26 Handbook of Fitting Statistical Distributions with R........71 Handbook of Food Analysis Instruments..........................59 Handbook of Food Analysis, Second Edition 3 Volume Set.....................................................................15 Handbook of Forensic Toxicology for Medical Examiners.........................................................................32

Image Processing with MATLAB: Applications in Medicine and Biology.......................................................................50 Immune-based Cancer Treatment: The T Iymphocyte Response.............................................................................9 Implementing Quality in Laboratory Policies and Processes: Using Templates, Project Management, and Six Sigma......63 In Vivo Optical Imaging of Brain Function, Second Edition..................................................................21

Laboratory Biosecurity Handbook....................................15 A Laboratory Course in Biomaterials................................39 Laboratory Mouse and Laboratory Rat Procedural Techniques: Manuals and DVDs.......................................11 Laboratory Mouse Procedural Techniques: Manual and DVD.................................................................................11 Laboratory Rat Procedural Techniques: Manual and DVD.............................................................11 Linear Mixed Models: A Practical Guide Using Statistical Software............................................................................81

Handbook of HPLC, Second Edition...............................59

Infectious Diseases and Pathology of Reptiles: Color Atlas and Text............................................................................10

Handbook of Laboratory Animal Science, Volume I, Third Edition: Essential Principles and Practices...............10

Inflammation, Life Style and Chronic Diseases: The Silent Link....................................................................................3

Lipid Oxidation Pathways, Volume Two.............................3

Handbook of Laboratory Animal Science, Volume II, Third Edition: Animal Models..........................................10

Informatics in Medical Imaging........................................51

Liquid Chromatography-Mass Spectrometry, Third Edition....................................................................36

Handbook of Markov Chain Monte Carlo........................79

Instrumental Data for Drug Analysis, Third Edition 6 Volume Set.....................................................................32

Handbook of Microbiological Media, Fourth Edition.......15 Handbook of Near-Infrared Analysis, Third Edition.........59 Handbook of Nucleic Acid Purification............................19 Handbook of Nutraceuticals and Functional Foods, Second Edition..................................................................26 Handbook of Nutrition and Food, Second Edition...........27 Handbook of Nutrition in the Aged, Fourth Edition........27 Handbook of Photonics for Biomedical Science................46 Handbook of Physics in Medicine and Biology.................53 Handbook of Prebiotics....................................................27 Handbook of Prebiotics and Probiotics Ingredients: Health Benefits and Food Applications.............................27 Handbook of Solubility Data for Pharmaceuticals............66 Handbook of Spatial Statistics...........................................88 A Handbook of Statistical Analyses Using R, Second Edition..................................................................79 A Handbook of Statistical Analyses using SAS, Third Edition....................................................................79 Handbook of Statistical Analyses Using Stata, Fourth Edition..................................................................79 Handbook of Venoms and Toxins of Reptiles....................32 Handbook of Vitamins, Fourth Edition............................27 Hansen Solubility Parameters: A Userâ&#x20AC;&#x2122;s Handbook, Second Edition..................................................................35 Healthcare Biotechnology: A Practical Guide....................56 Healthcare Sensor Networks: Challenges Toward Practical Implementation................................................................46 Hierarchical Modeling and Analysis for Spatial Data, Second Edition..................................................................80 Histologic Basis of Mouse Endocrine System Development: A Comparative Analysis....................................................10 Human Error in Medicine, Second Edition......................65

Insect Physiology and Biochemistry, Second Edition.........36

Integrated Microsystems: Materials, MEMs, Photonics, Bio Interfaces...........................................................................80 International Poisonous Plants Checklist: An EvidenceBased Reference................................................................32 Introducing Food Science.................................................27 Introduction to Biology and Biotechnology, Second Edition..................................................................56 Introduction to Bio-Ontologies.........................................72 Introduction to Complexity and Complex Systems...........46 Introduction to Computational Proteomics......................30 Introduction to Engineering Mechanics: A Continuum Approach..........................................................................46 Introduction to Experimental Biophysics: Biological Methods for Physical Scientists.........................................53 Introduction to Nanoscience.............................................61 Introduction to Nanoscience and Nanotechnology...........61 Introduction to Natural Products Chemistry....................68 Introduction to Nutrition and Metabolism, Fourth Edition..................................................................28 Introduction to Peptides and Proteins...............................30 Introduction to Proteins: Structure, Function, and Motion.......................................................................53 Introduction to Statistical Data Analysis for the Life Sciences.............................................................................80 Introduction to Statistical Limit Theory............................80

Linear Models with R........................................................81 Lipid-Mediated Signaling....................................................4

Longitudinal Data Analysis...............................................81 Lycopene: Nutritional, Medicinal and Therapeutic Properties..........................................................................28

M Macroporous Polymers: Production Properties and Biotechnological/Biomedical Applications........................39 Making and Using Antibodies: A Practical Handbook........9 Maldynia: Multidisciplinary Perspectives on the Illness of Chronic Pain.....................................................................22 Management of Laboratory Animal Care and Use Programs...........................................................................12 Managing the Laboratory Animal Facility, Second Edition..................................................................12 Manipulative Tenants: Bacteria Associated with Arthropods........................................................................15 Mass Spectrometry of Nucleosides and Nucleic Acids.......60 Mass Spectrometry: A Basic Approach..............................60 Materials Science for Dentistry, Ninth Edition..................40 Materials Science of DNA.................................................40 Mathematical and Experimental Modeling of Physical and Biological Processes...........................................................89 Measurement Error in Nonlinear Models: A Modern Perspective, Second Edition...............................................81 Measures of Interobserver Agreement and Reliability, Second Edition..................................................................81 Mechanobiology Handbook..............................................47

Ion-Pair Chromatography and Related Techniques...........59

Medical and Healthcare Textiles 2007: Proceedings of the Fourth International Conference on Healthcare and Medical Textiles..............................................................................40

Medical Biostatistics, Second Edition................................82

Introduction to Statistical Methods for Clinical Trials.......86

Jet Fuel Toxicology............................................................33

Title Index

Handbook of Anatomical Models for Radiation Dosimetry.........................................................................45

Medical Nanotechnology and Nanomedicine....................47 Melatonin in the Promotion of Health, Second Edition....28 Meta-analysis and Combining Information in Genetics and Genomics..........................................................................72

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Metals for Biomedical Devices..........................................40 Methods for the Study of Deep-Sea Sediments, Their Functioning and Biodiversity............................................16 Methods in Medical Informatics: Fundamentals of Healthcare Programming in Perl, Python, and Ruby.........72 Methods of Behavior Analysis in Neuroscience, Second Edition..............................................................................22 Micro and Nano Techniques for the Handling of Biological Samples.............................................................................57 Microarray Innovations: Technology and Experimentation...............................................................72 Microarray Methods and Protocols...................................19 Microbial Limit and Bioburden Tests: Validation Approaches and Global Requirements,Second Edition......16 Microbiology of Wounds..................................................16

Title Index

Microfabricated Cortical Neuroprostheses........................22 Micronutrients and Brain Health......................................22 Missing Data in Longitudinal Studies: Strategies for Bayesian Modeling and Sensitivity Analysis.......................82 Mixed Effects Models for Complex Data..........................82 Mixture Toxicity: Linking Approaches from Ecological and Human Toxicology............................................................33 Modelling and Quantitative Methods in Fisheries, Second Edition..................................................................82 Modelling Survival Data in Medical Research, Second Edition..............................................................................82 Modern Soil Microbiology, Second Edition......................16 Molecular Detection of Foodborne Pathogens..................16 Molecular Detection of Human Bacterial Pathogens.........16 Molecular Detection of Human Fungal Pathogens............17 Molecular Detection of Human Viral Pathogens...............17 Monte Carlo Simulation for the Pharmaceutical Industry: Concepts, Algorithms, and Case Studies...........................82 Multi-dimensional QSAR: Methods and Applications for Drug Discovery and Polymer Science................................65

Multiple Comparisons Using R.........................................83 Multiple Testing Problems in Pharmaceutical Statistics.....63 Multiscale Cancer Modeling.............................................90 Multivariate Geostatistical Models: Inference and Computation....................................................................83 Multivariate Statistical Methods: A Primer, Third Edition....................................................................83 Muscles of Vertebrates: Comparative Anatomy, Evolution, Homologies and Development............................................7

Nanotechnology 2010: Fabrication, Particles, Characterization, MEMs, Electronics and Photonics; Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo (Volume 1).....................................62 Nanotechnology 2010: Life Sciences, Medicine, Diagnostics, Bio Materials and Composites; Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo (Volume 2)........................................................62 Nanotechnology For the Life Sciences: Fundamentals and Applications......................................................................61 Nanotechnology in Tissue Engineering and Regenerative Medicine...........................................................................62 Neurobiology of Huntington’s Disease: Applications to Drug Discovery.................................................................22 Neurobiology of Sensation and Reward.............................23 Neuroproteomics..............................................................23 Neurotechnology: Premises, Potential and Problems.........23 Nuclear Medicine Physics.................................................51 Nutrients and Epigenetics.................................................28 Nutrition in Public Health: Principles, Policies, and Practice.......................................................................28 Nutrition Support for the Critically Ill Patient: A Guide to Practice.............................................................................28 Nutrition, Physical Activity, and Health in Early Life, Second Edition..................................................................29 Nutritional Concerns in Recreation, Exercise, and Sport...29 Nutritional Genomics: The Impact of Dietary Regulation of Gene Function on Human Disease...................................29 Nutritional Management of Digestive Disorders...............29

O Obesity: Epidemiology, Pathophysiology, and Prevention.........................................................................29 Omega-3 Fatty Acids and the DHA Principle...................36 OMICS: Biomedical Perspectives and Applications...........57 Optical Tweezers: Methods and Applications....................53 Optimal Design for Nonlinear Response Models..............83

Physical Enhancement Strategies for Topical and Transdermal Drug Delivery...............................................10 Physics for Diagnostic Radiology, Third Edition...............47 Physiology, Biophysics and Biomedical Engineering..........48 Pictorial Atlas of Soil and Seed Fungi: Morphologies of Cultured Fungi and Key to Species,Third Edition.............17 Polar Microbiology: The Ecology, Biodiversity and Bioremediation Potential of Microorganisms in Extremely Cold Environments...........................................................17 Polymeric Biomaterials, Revised and Expanded.................10 Polyolefin Fibres: Industrial and Medical Applications......41 Polyurethane Shape-Memory Polymers.............................41 Porous Media: Applications in Biological Systems and Biotechnology...................................................................48 Postharvest Biology and Technology for Preserving Fruit Quality..............................................................................29 Practical Atlas for Bacterial Identification, Second Edition..................................................................17 A Practical Guide to Assay Development and HighThroughput Screening in Drug Discovery........................65 Practical Guide to Clinical Data Management, Second Edition..............................................................................87 Practical Handbook of Microbiology, Second Edition.......17 Practical Statistical Methods: A SAS Programming Approach..........................................................................83 Practical Statistics for Medical Research............................83 Principles and Practice of Bioanalysis, Second Edition......37 Principles and Practices of Plant Genomics, Volume 3: Advanced Genomics..........................................................72 Probiotic Foods in Health and Disease..............................18 Protein Discovery Technologies.........................................31 Protein Engineering and Design........................................31 Protein Folding and Metal Ions: Mechanisms, Biology and Disease..............................................................................19 Proteins: Energy, Heat and Signal Flow.............................31 Python for Bioinformatics.................................................73

Organic Chemistry: An Acid—Base Approach..................36 Organic Chemist’s Desk Reference, Second Edition..........36

P Paediatric Rehabilitation Engineering: From Disability to Possibility..........................................................................47 Parkinson’s Disease, Second Edition..................................23 Pharmaceutical Dosage Forms and Drug Delivery............69

Quality and Safety in Radiotherapy...................................42 Quality Assurance and Quality Control in the Analytical Chemical Laboratory: A Practical Approach......................66 Quality Control Training Manual: Comprehensive Training Guide for API, Finished Pharmaceutical and Biotechnologies Laboratories.............................................42

Pharmacoeconomics: From Theory to Practice..................63

Quantitative Drug Design: A Critical Introduction, Second Edition..................................................................65

Nano- and Biocomposites.................................................60

Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Fourth Edition......................68

Quantitative Understanding of Biosystems: An Introduction to Biophysics..........................................53

Pharmacy Fits: Practical Tactics for Integrating Medication Related Computer Systems, Teams and Processes..............69

Pharmacy: What It Is and How It Works, Third Edition....................................................................69

R Programming for Bioinformatics...................................73

Nanobiomaterials Handbook............................................61 Nanofabrication Handbook..............................................61 Nanosensors: Theory and Applications in Industry, Healthcare and Defense....................................................61 Nanotech 2010: Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo (Volumes 1-3)......62 Nanotechnology 2010: Biofuels, Renewable Energy, Coatings and Compact Modeling; Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo (Volume 3)........................................................................62

Phenotypic Plasticity of Insects: Mechanisms and Consequences.....................................................................7 Photoacoustic Imaging and Spectroscopy..........................51 Photographic and Descriptive Musculoskeletal Atlas of Gorilla: With Notes on the Attachments, Variations, Innervation, Synonymy and Weight of the Muscles............7

Radiopharmaceuticals: Introduction to Drug Evaluation and Dose Estimation................................................................66 Randomization, Bootstrap and Monte Carlo Methods in Biology, Third Edition......................................................73 Randomized Clinical Trials of Nonpharmacologic Treatments........................................................................87 Rapid Detection and Characterization of Foodborne Pathogens by Molecular Techniques..................................18

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Regulation of Gene Expression by Small RNAs.................19

Targeted Delivery of Small and Macromolecular Drugs....64

Reliable Design of Medical Devices, Second Edition.........48

TechConnect World 2010 Proceedings: Nanotech, Clean Technology, Microtech, Bio Nanotech Proceedings DVD.................................................................................62

Reproductive Biology and Phylogeny of Chondrichthyes: Sharks, Batoids, and Chimaeras, Volume 3.........................7 Reproductive Biology and Phylogeny of Fishes, Vol 8B: Part B: Sperm Competion Hormones.................................7 Reproductive Biology and Phylogeny of Fishes, Vol. 8A: Part A: Phylogeny Morphology Hormones Fertilization......8 Reversibility of Chronic Degenerative Disease and Hypersensitivity, Volume 1: Regulating Mechanisms of Chemical Sensitivity..........................................................33 Robust Nonparametric Statistical Methods, Second Edition..................................................................84

S Sample Size Calculations in Clinical Research, Second Edition N-Solution bundle version.......................87

Testing Statistical Hypotheses of Equivalence and Noninferiority, Second Edition.........................................85 Textbook of Drug Design and Discovery, Fourth Edition..................................................................66 Textbook of Receptor Pharmacology, Third Edition..........68 The Alga Dunaliella..........................................................13 The Biology of Blennies......................................................5 The Biology of Lungfishes...................................................5 The Biomedical Engineering Handbook, Third Edition 3 Volume Set.....................................................................43 The Chemical Components of Tobacco and Tobacco Smoke.................................................................31

Sample Sizes for Clinical Trials..........................................87

The COST Manual of Laboratory Animal Care and Use: Refinement, Reduction, and Research.................................9

SAS and R: Data Management, Statistical Analysis, and Graphics............................................................................84

The Delivery of Regenerative Medicines and Their Impact on Healthcare......................................................................3

Semiconductor Radiation Detection Systems....................52

The Female Brain, Second Edition....................................21

Sensory Evaluation Techniques, Fourth Edition................18

The IACUC Handbook, Second Edition..........................10

Serving People with Food Allergies: Kitchen Management and Menu Creation...........................................................30 Sexuality in Fishes...............................................................8 Shape Memory Alloys for Biomedical Applications...........41 Signal Processing in Magnetic Resonance Spectroscopy with Biomedical Applications....................................................52

The Image Processing Handbook, Sixth Edition...............50 The Integrated Nervous System: A Systematic Diagnostic Approach..........................................................................22 The ISO 13485 Standard: A Complete Guide to Quality Control.............................................................................39

The Structure of Biological Membranes, Third Edition......4 Three dimensional QSAR: Applications in Pharmacology and Toxicology..................................................................66 Time Series Modeling of Neuroscience Data.....................85 Titanium: Modelling Microstructure, Properties and Applications......................................................................41 Topical Antimicrobials Testing and Evaluation, Second Edition..................................................................18 Translational Pain Research: From Mouse to Man.............24 Transport Phenomena Fundamentals, Second Edition......48 Trans-ungual Drug Delivery..............................................64 Traumatic Brain Injury: Methods for Clinical and Forensic Neuropsychiatric Assessment, Second Edition...................24 Traumatic Brain Injury: Rehabilitation, Treatment, and Case Management, Third Edition.............................................24 TRP Channels..................................................................24 Two-Dimensional Optical Spectroscopy...........................60

U Understanding Medical Terms: A Guide for Pharmacy Practice, Second Edition...................................................69 Usability Testing of Medical Devices.................................41 Using Mass Spectrometry for Drug Metabolism Studies, Second Edition..................................................................60 Using R for Data Management, Statistical Analysis, and Graphics............................................................................84 Using SAS for Data Management, Statistical Analysis, and Graphics............................................................................84

The Laboratory Canine.....................................................11

Signaling Mechanisms of Oxygen and Nitrogen Free Radicals.............................................................................37

The Laboratory Guinea Pig, Second Edition.....................11

Vertebrates: Structures and Functions.................................8

The Laboratory Hamster and Gerbil.................................11

Signals and Systems Analysis In Biomedical Engineering, Second Edition..................................................................48

Veterinary Clinical Epidemiology, Third Edition..............88

The Laboratory Mouse......................................................11

Vibrational Spectroscopy for Tissue Analysis.....................54

The Laboratory Nonhuman Primate.................................11

Vitamin K in Health and Disease......................................30

The Laboratory Rabbit, Second Edition............................11

W-Z

Simultaneous Inference in Regression...............................84 Statistical Analysis for Decision Makers in Healthcare, Second Edition: Understanding and Evaluating Critical Information in Changing Times........................................84 Statistical Analysis of Medical Data Using SAS.................84 Statistical Computing with R............................................85 Statistical Physics of Biomolecules: An Introduction.........53 Statistical Thinking in Epidemiology................................88 Statistics for Biological Networks: How to Infer Networks from Data.........................................................................73 Statistics for Epidemiology................................................88 Statistics in Human Genetics and Molecular Biology........73 Statistics of Medical Imaging.............................................73 Stem Cell Labeling for Delivery and Tracking using Non-invasive Imaging.........................................................4

The Laboratory Rat, Second Edition.................................11 The Laboratory Swine, Second Edition.............................12

Water and Life: The Unique Properties of H20..................37

The Laboratory Xenopus sp................................................12

Water-Insoluble Drug Formulation, Second Edition.........66

The Laboratory Zebrafish.................................................12

Whatâ&#x20AC;&#x2122;s New About Crop Plants: Novel Discoveries of the 21st Century.......................................................................4

The Law of Regenerative Medicine and Tissue Engineering.......................................................................46 The Measurement, Instrumentation and Sensors Handbook.........................................................................47 The Medical Device R&D Handbook..............................47 The Metabolic Pathway Engineering Handbook, Two Volume Set........................................................................57 The Metabolic Pathway Engineering Handbook: Fundamentals....................................................................57

Stochastic Modelling for Systems Biology.........................74

The Metabolic Pathway Engineering Handbook: Tools and Applications......................................................................57

Structure and Function of Intrinsically Disordered Proteins.............................................................................31

The Neural Bases of Multisensory Processes......................21

Support Vector Machines and Their Application in Chemistry and Biotechnology...........................................57 Swine in the Laboratory: Surgery, Anesthesia, Imaging, and Experimental Techniques, Second Edition........................12 Systems Biology and Bioinformatics:: A Computational Approach..........................................................................74

Title Index

Regenerative Medicine and Biomaterials for the Repair of Connective Tissues............................................................41

The Neurobiology of Olfaction.........................................23 The Physics of Medical Imaging, Second Edition..............51 The Physiology of Bioelectricity in Development, Tissue Regeneration and Cancer..................................................48 The Physiology of Fishes, Third Edition.............................7 The Role of Dopamine in the Basal Ganglia.....................23 The Science of Imaging, Second Edition...........................51

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A Abbott; Albert G.........................................................38, 72 Abdala; Virginia..................................................................7 Abuhav; Itay......................................................................39 Acharya U; Rajendra.........................................................71 Adeli; Hojjat.....................................................................20 Adriaensen; Dirk.................................................................4 Afanasâ&#x20AC;&#x2122;ev; Igor B...............................................................37 Aggarwal; Bharat B.............................................................3 Aislabie; Jackie..................................................................17 Akoh; Casimir C...............................................................26 Alexander; Michael A..........................................................9 Allen; Linda J. S................................................................89

Author Index

Allen; Matthew J...............................................................11 Allman; A.R......................................................................14 Alon; Uri...........................................................................89 Altman; Douglas G...........................................................83 Altman; Joseph....................................................................4 Alzate; Oscar.....................................................................23 Ambrosio; L......................................................................39 Anand; S.C.......................................................................40 Ananthakrishnan; T.N.........................................................7 Anderson; Stewart.............................................................76 Aoki-Kinoshita; Kiyoko F..................................................71 Arap; Wadih......................................................................31 Archer; Charles.................................................................41 Arnold; Renee J. G............................................................63 Arora; Himanshu..............................................................56 Arthurs; Susan...................................................................21 Ashby; Richard..................................................................37 Ashley; Mark J..................................................................24 Ashtok; Anika...................................................................54 Asif Syed; Erfan.................................................................42

Barnett; Adrian.................................................................80

Asif; Erfan Syed.................................................................62 Asyali; Musa Hakan..........................................................50 Atala; Anthony..................................................................38 Atlas; Ronald M..........................................................15, 17 Awad; Atif B.....................................................................24

Barrow; John D.................................................................37 Bassi; Sebastian.................................................................73 Bates; Declan....................................................................71 Bauer; Jeffrey C.................................................................84 Bauer; Sebastian................................................................72 Bayer; Shirley A...................................................................4 Begg; Rezaul......................................................................46 Bej; Asim K.......................................................................17 Belkic; Dzevad..................................................................52 Belkic; Karen.....................................................................52 Bell; Suzanne.....................................................................59 Bello; Gaelle........................................................................7 Ben-Amotz; Ami ..............................................................13 Bender; Andreas . .............................................................71 Bender; David A...............................................................28 Bennett; B. Taylor.............................................................11 Ben-Tal; Nir......................................................................53 Berdanier; Carolyn D............................................24, 25, 27 Berdanier; Lynne...............................................................25 Berman; Jules J..................................................................72 Berry; Scott M..................................................................85 Best; Serena M..................................................................39 Bhunia; Arun....................................................................14 Bhutani; S. P......................................................................34 Bidlack; Wayne R..............................................................29 Bin; Yang..........................................................................41 Blackburn; Clive de W......................................................14 Blanco; Carlos...................................................................38 Blunt; John W...................................................................64 Boas; David A...................................................................46 Bogdanske; John J.............................................................12 Bogner; Marilyn Sue.........................................................65 Bohlin; Lars......................................................................65 Bollen; Peter J. A...............................................................11 Bonilla; Jose V...................................................................56 Bourtzis; Kostas.................................................................15 Boutron; Isabelle...............................................................87 Bradford; Peter G..............................................................24 Bradley; Richard................................................................45

Badilescu; Simona.............................................................70 Bagchi; Debasis...........................................................25, 29 Baggaley; Keith H.............................................................67 Baird; Rosamund M..........................................................15 Bandos; Andriy.................................................................74 Banerjee; Bhaskar..............................................................29 Banerjee; Sudipto..............................................................80 Banga; Ajay K...................................................................40 Banks; H.T........................................................................89 Banoub; Joseph H.............................................................60 Barbosa; Mercedex..............................................................7 Bar-Cohen; Yoseph............................................................44 Barh; Debmalya................................................................57 Barnes; Frank S.................................................................45

Branscum; Adam...............................................................75 Brayton; Cory...................................................................11 Bretz; Frank................................................................63, 83 Brock; Kristy Kay..............................................................50 Broemeling; Lyle D...........................................................85 Bronzino; Joseph D...........................................................43 Brooks; Stephen..........................................................75, 79 Brown; Peggy A.................................................................87 Brown; Ted.......................................................................20 Bryce; C. F. A....................................................................14 Buccafusco; Jerry J............................................................22 Buckingham; John............................................................67 Burns; Donald A...............................................................59 Burns; Mark D..................................................................32

Cabrini; Stefano................................................................61 Cadenas; Enrique..............................................................22 Carlin; Bradley P...................................................75, 80, 85 Carr; B. Thomas...............................................................18 Carroll; Raymond J...........................................................81 Castillo; Jaime...................................................................57 Cavalier; Annie.................................................................58 Cazes; Jack........................................................................58 Cecchi; Teresa...................................................................59 Chakrabarty; Krishnendu..................................................55 Chandran; Krishnan B......................................................42 Chang; Mark...............................................................82, 85 Chau; Tom........................................................................47 Chauhan; Abha.................................................................20 Chauhan; Ved...................................................................20 ChauviĂ¨re; Arnaud ...........................................................89 Chen; Ding-Geng.............................................................76 Chen; Jake Y......................................................................76 Chen; Taosheng................................................................65 Cheung; Ying Kuen..........................................................77 Chirila; T. V......................................................................38 Chitturi; Pallavi.................................................................76 Cho; Minhaeng.................................................................60 Cho; Susan Sungsoo..........................................................27 Choi; Sang-Woon.............................................................28 Choi; Taeryon...................................................................78 Chow; Shein-Chung.............................................85, 86, 87 Christensen; Douglas A.....................................................42 Christensen; Ronald..........................................................75 Christian, Jr.; Donnell R...................................................63 Ciurczak; Emil W..............................................................59 Civille; Gail Vance............................................................18 Claiborne; James B..............................................................7 Clegg; Robert M...............................................................52 Clemons; Donna J............................................................11 Cleves; Mario....................................................................81 Clontz; Lucia....................................................................16 Cochran; Jennifer R..........................................................31 Colegate; Steven M...........................................................34 Collett; David...................................................................82 Cook; Mark......................................................................21 Cook; Thomas D..............................................................86 Cooper; Caroline..............................................................36 Corradini; Danilo.............................................................59 Cosentino; Carlo...............................................................71 Craig; Fiona Elizabeth.......................................................19 Crainiceanu; Ciprian M....................................................81 Cravatt; Benjamin F..........................................................30 Cree; Michael J.................................................................49 Cresci; Gail.......................................................................28 Cruse; Julius M...................................................................8 Cullimore; D. Roy............................................................17 Cutting; Keith...................................................................16

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Ebadi; Manuchair ............................................................23

Daczkowska-Kozon; E. Grazyna ......................................32

Eckerman; Keith F.............................................................45

Danguy; André...................................................................9

Eggersdorfer; Manfred......................................................22

Daniels; Michael J.............................................................82

Ehrlich; Henry Lutz..........................................................15

Danneman; Peggy.............................................................11

Eichelberger; Christopher N.............................................74

Danovaro; Roberto...........................................................16

Ekstrom; Claus Thorn.......................................................80

Darlington; Cynthia L......................................................21

Elias; Anil J.......................................................................33

Dartois; Veronique..............................................................9

Ellison; M.........................................................................38

Darvell; B. W....................................................................40

El-Mansi; E. M. T.............................................................14

Dasgupta; Amitava............................................................63

Esposito; Emilio................................................................65

Davidian; Marie................................................................81

Esteller; Manel..................................................................18

Dawood; Mohammad.......................................................50

Evans; David H...................................................................7

De Lima; Joao Jose............................................................51

Evans; G.O.........................................................................9

De Muth; James E.............................................................75

Everitt; Brian S............................................................79, 84

Deisboeck; Thomas S........................................................90

Demain; A. L....................................................................14 DeMets; David L..............................................................86 Demirkaya; Omer.............................................................50 Dendy; Philip Palin...........................................................47 Denstedt; John..................................................................38 Denyer; Stephen P.............................................................15 dePaz; Felix J.......................................................................7 Der; Geoff...................................................................79, 84 Desalle; Rob........................................................................6 Devillers; James.................................................................31 Dey; Dipak K..............................................................69, 78 Di Loreto; Veronica Elina..................................................10 Di Silvio; Lucy..................................................................39 Dick; Thomas.....................................................................9 Diggle; Peter.....................................................................88 Dimaki; Maria..................................................................57 Diogo; Rui......................................................................6, 7 Dmitrienko; Alex..............................................................63 Dobson; Annette J............................................................80 Dogramatzis; Dimitris.......................................................56 Domenici; Paolo ................................................................6 Donnenberg; Albert D......................................................19 Dorodnitsyn; Vladimir......................................................88 Doucet; Jean Pierre...........................................................66 Douglas; Fred A................................................................12 Drilling; Stephanie............................................................63 Driskell; Judy A.................................................................29 D’sa; Raechelle A...............................................................61 Dua; Sumeet.....................................................................71 Dudewicz; Edward J.........................................................72 Dumitriu; Severian............................................................40 Dunscombe; Peter B.........................................................42 Durney; Carl H.................................................................42 Dutta; Joydeep..................................................................61 Dwyer; Johanna................................................................27 Dym; Clive L....................................................................46

Fairclough; Diane L..........................................................86 Fairley; Jillian....................................................................47 Falissard; Bruno................................................................74 Fanun; Monzer............................................................55, 64 Faraway; Julian J.........................................................78, 81 Farnworth; Edward R........................................................26 Faulon; Jean-Loup.............................................................71 Fedorov; Valerii V..............................................................83 Feldman; Elaine B.............................................................27 Ferrero; Eva M....................................................................7 Fersht; Alan.......................................................................31 Field; Garrett.....................................................................11 Field; Karl J.......................................................................11 Finney; John L..................................................................37 Finocchiaro; Terry.............................................................27 Fitzmaurice; Garrett..........................................................81 Floris; Giovanni................................................................35 Foreman; John C...............................................................68 Fortman; Jeffrey D............................................................11 Fournier; Ronald L............................................................42 Frei; Mark G.....................................................................21 Fries; Richard C..........................................................45, 48 Friso; Simonetta................................................................28

Gelfand; Alan E..........................................................80, 88 Gelman; Andrew...............................................................79 Genten; Franck ..................................................................9 Gentleman; Robert ..........................................................73 Gharibzadeh; Shahriar .....................................................74 Ghosh; Dilip K.................................................................25 Ghosh; Samiran ...............................................................69 Ghosh-Dastidar; Samanwoy..............................................20 Gibb; Alasdair J.................................................................68 Gibson; Glenn R...............................................................27 Gill; Jeff............................................................................76 Gilthorpe; Mark S.............................................................88 Gimenez; Olivier...............................................................75 Giordano; James ........................................................22, 23 Gogol-Döring; Andreas.....................................................70 Gohlmann; Hinrich..........................................................71 Goldman; Emanuel...........................................................17 Goldstein; Darlene R........................................................72 Gomes; Claudio M...........................................................19 Gonçalves; Emanuel J.........................................................5 Gottfried; Jay A.................................................................23 Gould; William.................................................................81 Granacher, Jr.; Robert P.....................................................24 Grande; Terry . ...................................................................6 Graslund; Astrid................................................................30 Greaves; John....................................................................60 Green; Lorrence H............................................................17 Green; Sherril L.................................................................13 Greenebaum; Ben.............................................................45 Grewal; Iqbal S.................................................................30 Grinberg; Nelu..................................................................58 Grote; James......................................................................40 Grushka; Eli......................................................................58 Guerra; Rudy....................................................................72 Guha; Sushovan..................................................................3 Guo; M.............................................................................26 Gupta; B. D......................................................................33 Gupta; U. S.........................................................................4 Gutierrez; Roberto............................................................81 Guttorp; Peter...................................................................88

Frostig; Ron......................................................................21 Frydenberg; Morten..........................................................80 Fu; Yong Qing..................................................................41 Fuentes; Montserrat..........................................................88 Fulekar; M. H...................................................................13 Fung; Glenn......................................................................51 Furse; Cynthia...................................................................42

G Gabrielsson; Johan............................................................68 Galeaev; Igor.....................................................................39 Galecki; Andrzej T.............................................................81 Gaudioso; Jennifer............................................................15 Gaur; Rajesh K..................................................................19

Author Index

Cutz; Ernest........................................................................4

Haddon; Malcolm.............................................................82 Hagen; Wilfred Raymond.................................................34 Haider; Syed Imtiaz..............................................42, 54, 62 Halliday; Lisa....................................................................11 Hamlett; William C. ..........................................................7 Hanrahan; Grady..............................................................74 Hansen; Axel Kornerup.....................................................11 Hansen; Charles M...........................................................35 Hanson; Timothy E..........................................................75 Hardiman; Gary................................................................72 Hardin; James...................................................................79 Harper; Charles.................................................................37 Harper; Claudia................................................................13

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Author Index

Hassanien; Aboul Ella.......................................................49

Jamieson; Barrie G. M........................................................7

Krull; Ira S........................................................................65

Hastings; Philip A...............................................................5

Jansson; Janet K................................................................16

Kuang; Yang......................................................................89

Hau; Jann.........................................................................10

Jedrychowski; Lucjan..........................................................8

Kucklick; Theodore R.......................................................47

Hayes; Douglas.................................................................37

Jelinek; Herbert F..............................................................49

Kuhn; Cynthia M.............................................................19

Hayes; Richard J...............................................................76

Jewell; Nicholas P..............................................................88

Kulczykowska; Ewa.............................................................5

Haynes; William M...........................................................62

Jiang; Huabei....................................................................50

Kumar; Ashok...................................................................39

He; Hua............................................................................74

Jiang; Jianmin...................................................................49

Kumar; Shrawan...............................................................45

He; Weixuan.....................................................................65

Jiang; Xiaoyi......................................................................50

Kumar; T .S. Sampath.......................................................60

He; Yan.............................................................................35

Jin; Jung-II........................................................................40

Kunz; Yvette W ..................................................................5

Heaton; Brian...................................................................47

Johansen; Torben..............................................................68

Kupper; Lawrence L..........................................................77

Hedaya; Mohsen A............................................................68

Johnson; Arthur T.............................................................43

Hefferon; Kathleen Laura..................................................63

Johnson; Wesley ...............................................................75

Heldman; Dennis R..........................................................55

Jones; D.S.........................................................................89

Lacroix; Dacroix................................................................39

Hendelman; Walter...........................................................22

Jones; Galin.......................................................................79

Lafdi; Khalid.....................................................................60

Herbert; Katherine G........................................................70

Jones; Sarah.......................................................................67

Lai; Daniel Tze Huri.........................................................46

Hernandez; Maria A..........................................................67

Jonker; Martijs..................................................................33

Lamm; Ehud.....................................................................88

Herson; Jay.......................................................................86

Jorgensen; Jorden Morup....................................................5

Land; Tiit..........................................................................30

Hettmansperger; Thomas P...............................................84

Joss; Jean.............................................................................5

Landrum; John T..............................................................34

Hewett; Terry A................................................................11

Jouyban; Abolghasem........................................................66

Langel; Ulo.......................................................................30

Hilbe; Joseph....................................................................79

Julious; Steven A...............................................................87

Langer; Steve G.................................................................51

Hillery...............................................................................68

Juul; Svend........................................................................80

Larsson; Sven....................................................................52

Hogan; Joseph W..............................................................82

Laskowski; Ryszard............................................................33

Holt; Robert J...................................................................69

Kagadis; George C............................................................51

Lau; Francis C...................................................................25

Hoover; Dallas G..............................................................55

Kamal-Eldin; Afaf...............................................................3

Lawrence; Christian .........................................................13

Hopfinger; Anton J...........................................................65

Kammenga; Jan E.............................................................33

Lawson; Andrew...............................................................75

Hornyak; Gabor L............................................................61

Kapoor; B.G...................................................................5, 6

Lawson; John....................................................................77

Horton; Nicholas J............................................................84

Karian; Zaven A................................................................72

le Coutre; Johannes...........................................................21

Hosmane; Narayan S........................................................55

Kaser; Matthew R...............................................................9

Le; Sebastien ....................................................................78

Hothorn; Torsten........................................................79, 83

Kaufman; Matthew...........................................................10

Lee; J. Jack........................................................................85

Hou; Ching T...................................................................54

Kaufman; Peter B..............................................................56

Lei; Tianhu.......................................................................73

Howard; Bryan....................................................................9

Kawata; Satoshi.................................................................61

Leitner; David M..............................................................31

Howard; Gary C.................................................................9

Kelly; William N...............................................................69

Leong; Franz Joel................................................................9

Howl; John.......................................................................67

Kendler; Jonathan.............................................................41

Leonov; Sergei L................................................................83

Hu; Wei-Shou...................................................................63

Kennedy; J.F......................................................................40

Levin; Robert E.................................................................18

Hua; Tse-Chau..................................................................14

Kessel; Amit......................................................................53

Lewis; A............................................................................64

Huang; W. M....................................................................41

Khan; A. A........................................................................14

Lewis; Robert E...................................................................8

Hubbard-Van Stelle; Scott.................................................12

Kim; Se-Kwon...................................................................35

Li; Paul C.H.....................................................................56

Hughes; Robert E. ...........................................................22

King; Paul H.....................................................................45

Liang; Yizeng....................................................................57

Hull; T. R..........................................................................32

King; Ruth . .....................................................................75

Light; Alan R....................................................................24

Humbel; Bruno M............................................................58

Kisaalita; William S...........................................................57

Lim; Teik-Cheng...............................................................61

Humphreys; Peter.............................................................22

Kisia; S. M..........................................................................8

Limbach; Patrick A...........................................................60

Hussain; Farzana...............................................................60

Kitamoto; Dai...................................................................37

Liu; Aiyi............................................................................74

Husson; Francois...............................................................78

Kleinman; Ken..................................................................84

Liu; B. L............................................................................14

Koehler; Steven A..............................................................87

Liu; Dongyou.......................................................16, 17, 19

Kole; Chittaranjan.............................................................72

Liu; Rong..........................................................................66

Hollinger; Manifred A.......................................................67

Lau; Alan Kin-tak.............................................................60

Indrayan; Abhaya..............................................................82

Konieczka; Piotr................................................................66

Liu; Wei............................................................................84

Iniewski; Krzysztof............................................................50

Koob; George F.................................................................19

Liu; Yunhui.......................................................................43

Ivanov; Volodymyr............................................................55

Korfmacher; Walter A.......................................................60

Lloyd.................................................................................68

Koropatnick; James.............................................................3

Lo; Donald C. . ................................................................22

Kraitchman; Dara L............................................................4

Lonardi; Stefano................................................................76

Jackson; Todd A................................................................11

Krishnan; Sunil...................................................................3

Louis; Thomas A...............................................................75

Jacobson; Elliott................................................................10

Krishnaswamy; N R..........................................................67

Luer; Carl A........................................................................5

Jain; Parijat........................................................................35

Krogsgaard-Larsen; Povl....................................................66

Lundblad; Roger L..........................................33, 35, 36, 64

Jain; S. K...........................................................................14

Kruger; Lawrence..............................................................24

Lynden-Bell; Ruth M........................................................37

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P, Q

Morgan; Byron J.T............................................................75

MacCuish; John D............................................................77 MacCuish; Norah E..........................................................77 Macdonald; Fiona.............................................................36 Mackenzie; Gilbert............................................................77 Mackessy; Stephen P..........................................................32 Madsen; Ulf......................................................................66 Mahato; Ram I............................................................64, 69 Malinov; Savko.................................................................41 Mallick; Bani K.................................................................69 Manly; Bryan F.J.........................................................73, 83 Marchenko; Yulia..............................................................81 Mareels; Iven.....................................................................21 Markov; Marko S..............................................................42 Markram; Henry...............................................................20 Martin; Brent J..................................................................11

Morris; Keith....................................................................59 Morris; Max D..................................................................77 Morris; Simon Conway.....................................................37 Moulton; Lawrence H.......................................................76 Movasaghi; Zanyar............................................................54 Muller; Peter.....................................................................85 Mundt; Arno J..................................................................42 Munro; Murray H. G........................................................64 Murphy; Eric J....................................................................4 Murphy; Martin . .............................................................49 Murray; Micah M.............................................................21 Murthy; S. Narasimha.................................................64, 67 Murthy; Sreekant..............................................................10 Mutlu; Mehmet................................................................13 Myers; Chris J...................................................................52

Packer; Lester....................................................................22 Packirisamy; Muthukumaran............................................70 Padgett; Lakshmi...............................................................83 Padgett; Miles J.................................................................53 Pages; Jerome....................................................................78 Pakhomov; Andrei G........................................................42 Palaniswami; Marimuthu..................................................46 Panaye; Annick.................................................................66 Pandian; T. J........................................................................8 Papanicolaou; Andrew C...................................................45 Parizkova; Jana..................................................................29 Park; Sheldon J..................................................................31 Parker; Rolland S..............................................................20 Pasqualini; Renata.............................................................31 Pastor; Juan F......................................................................7

Martin; Yvonne Connolly.................................................65

Mascie-Taylor; C.G. Nicholas.............................................6

Nadeau; Jay.......................................................................53

Patzner; Robert A . .............................................................5

Matchett; Christian C.......................................................32

Nagatomi; Jiro..................................................................47

Paulson; Daryl S..........................................................13, 18

Mathis; A............................................................................6

Nagy; John........................................................................89

Pawlicki; Todd .................................................................42

Matson; Robert S..............................................................19

Nair; G. B.........................................................................18

Peace; Karl E...............................................................76, 86

Mattiasson; Bo..................................................................39

Najarian; Kayvan...............................................................74

Percival; Steven..................................................................16

Mayazaki; Shuichi.............................................................41

Najarian; Siamak...............................................................74

Perfetti; Thomas A............................................................31

Mcclure; Peter J.................................................................14

Namiesnik; Jacek...............................................................66

Periasamy; Ammasi...........................................................52

McCormick; Donald B.....................................................27

Nandi; Nilashis.................................................................35

Perretta; Gemma.................................................................9

McGloin; David................................................................53

Narang; Ajit S.............................................................64, 69

Perrière; C...........................................................................6

McKean; Joseph W............................................................84

Nation; James L................................................................36

Pfeiffer; Ronald F..............................................................23

Meilgaard; Morten C........................................................18

Patel; Kalpana...................................................................33

Neelon; Brian....................................................................77

Philips; Terry M................................................................59

Meng; Ellis........................................................................43

Nevalainen; Timo................................................................9

Pitris; Constantinos...........................................................46

Meng; Xiao-Li...................................................................79

Newman; Dianne K..........................................................15

Planell; Joseph A...............................................................39

Menini; Anna....................................................................23

Niessen; Sherry.................................................................30

Plank; Michael..................................................................89

Mentzer; Mark A...............................................................54

Niessen; Wilfried M.A......................................................36

Plawsky; Joel.....................................................................48

Mercanzini; Andre............................................................22

Niinomi; M......................................................................40

Polak; Dame Julia................................................................3

Merolli; Antonio...............................................................39

Nikitin; Alexander Yu........................................................10

Polansky; Alan M..............................................................80

Meseguer; J.........................................................................6

Nollet; Leo M.L................................................................15

Polle; Jürgen E.W..............................................................13

Meyers; Arlen D................................................................61

Nordlund; Thomas M.......................................................53

Pong; Annpey....................................................................86

Michnaik; Bozena B. . ......................................................43

Northrop; Robert B....................................................46, 48

Popat; Ketul......................................................................62

Michotte; Yvette................................................................58

NSTI................................................................................62

Popek; Wlodzimierz............................................................5

Miklavcic; Damijan...........................................................42

Nussinov; Ruth.................................................................30

Potau; Josep M....................................................................7

Mills, III; Terry.................................................................32 Min; David.........................................................................3

Pozrikidis; C......................................................................44

Min; David B....................................................................26

Oberg; P. Ake....................................................................43

Prasad; K. Satya.................................................................56

Miraftab; Mitsuo...............................................................40

O’Brien; Sean M...............................................................77

Preedy; Victor R................................................3, 25, 28, 54

Moher; David...................................................................87

Ohno-Machado; Lucila.....................................................74

Prescott; Catherine..............................................................3

Molenberghs; Geert..........................................................81

Oielska; Maria ...................................................................5

Preuss; Harry G.................................................................29

Molina, M.D.; D. K..........................................................32

Ollis, Jr.; Robert J.............................................................32

Preziosi; Luigi....................................................................89

Molloy; Justin...................................................................53

Olsen Alstrup; Aage Kristian.............................................11

Prokscha; Susanne.............................................................87

Molyneux; Russell J...........................................................34

Orgill; D...........................................................................38

Pullar; Christine E.............................................................48

Mondovi; Bruno...............................................................35

Osorio; Ivan......................................................................21

Purutcuoglu; Vilda............................................................73

Montmayeur; Jean-Pierre..................................................21

Otles; Semih.....................................................................59

Moore, James....................................................................44

Owusu-Apenten; Richard..................................................25

Moore; Faron....................................................................69

Ozaki; Tohru.....................................................................85

Rabe-Hesketh; Sophia.......................................................79

Moore; John J...................................................................61

Ozturk; Sadettin...............................................................63

Raghavarao; Damaraju......................................................76

Moraru; Carmen I.............................................................55

Poyato-Ariza; Francisco José................................................6

Rai; M. K. . ......................................................................14

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Author Index

Author Index 100

Rajendran; S...............................................................37, 40

Saxby; Graham..................................................................51

Street; Laurence J..............................................................44

Ralphs; Jim.......................................................................41

Scalliet; Pierre...................................................................42

Strochlic; Allison Yale........................................................41

Ramachandra; Renuka......................................................20

Schaefer; Gerald................................................................49

Stromgaard; Kristian.........................................................66

Ramakrishna; Seeram........................................................60

Schaefer; Joel.....................................................................30

Subramanian; Thyagarajan................................................20

Ramalingam ; Murugan....................................................60

Schafers; Klaus..................................................................50

Suckow; Mark A...................................................10, 11, 12

Ramanujam; Nimmi.........................................................46

Schapiro; Steven J.............................................................10

Sun Pan; Bonnie...............................................................32

Ranade; Vasant V...............................................................67

Schierwater; Bernd..............................................................6

Sun; Dong........................................................................43

Rankin-Riley; Margaret.....................................................12

Schiffman; Beth M............................................................12

Sundberg; John P...............................................................10

Rao; Anil K.......................................................................61

Schmidt; Bertil..................................................................70

Sung; Wing-Kin................................................................69

Rao; D.V. Subba...............................................................13

Schreiber; Gideon.............................................................30

Suttie; John W.............................................................27, 30

Rao; R. Bharat..................................................................51

Schroeder; Valerie..............................................................11

Sutton; Raul......................................................................34

Rathinavelu; Appu............................................................67

SebĂŠrt; Philippe . ................................................................5

Svendsen; Claus................................................................33

Ratti; Cristina...................................................................12

Segev; Idan........................................................................20

Svendsen; Winnie Edith....................................................57

Ravaud; Philippe...............................................................87

Semmlow; John L.............................................................49

Swarbrick; James...............................................................68

Ravishanker; Nalini...........................................................78

Serna-Saldivar; Sergio O....................................................25

Swartz; Michael E.............................................................65

Ray; Bibek.........................................................................14

Serrano; Maria..................................................................29

Swindells; Peter G.............................................................34

Rea; William J...................................................................33

Sha; Wei............................................................................41

Swindle; M. Michael.........................................................12

Reddy; K. Pratap...............................................................56

Shalliker; R. Andrew.........................................................59

Szabo; Laszlo F..................................................................67

Rehman; Ihtesham Ur.......................................................54

Shao; Jun...........................................................................87

Rehman; Shazza................................................................54

Sharma; C. P.....................................................................37

Reilly; Cavan.....................................................................73

Sharon; Madhuri...............................................................44

Tadeo; Jose L.....................................................................13

Reinert; Knut....................................................................70

Sharon; Maheshwar...........................................................44

Tagawa; Tatsuo..................................................................43

Reisman; Stanley...............................................................43

Sharp; Patrick E................................................................11

Takeda; Yoshifumi.............................................................18

Reisner; David E...............................................................44

Shaw; Jei-Fu......................................................................54

Talloen; Willem................................................................71

Renaud; Philippe .............................................................22

Shewfelt; Robert L............................................................27

Tamhane; Ajit C...............................................................63

Rho; Jong..........................................................................20

Shi; Jian Qing...................................................................78

Tamura; Toshiyo...............................................................43

Rigalli; Alfredo..................................................................10

Shoukri; Mohamed M......................................................81

Tang; Wan.........................................................................74

Ritchie; Glenn David........................................................33

Sibold; Amber L................................................................11

Teixeira; Marie B...............................................................45

Ritter; Arthur B................................................................43

Sies; Helmut.....................................................................22

Templeton; Nancy Smyth...................................................3

Rittgers; Stanley E.............................................................42

Silverman; Jerald.........................................................10, 12

Terrill Lisabeth A..............................................................11

Rizzo; Maria L..................................................................85

Simon; Mathew J..............................................................32

Terwinghe; Eddy.................................................................9

Roberfroid; Marcel B........................................................27

Sitharaman; Balaji.............................................................61

Tibbals; Harry F..........................................................47, 61

Roberson; James Conrad...................................................32

Skinner; Christopher.........................................................22

Tollefsbol; Trygve..............................................................18

Roberts; Andrew D...........................................................67

Skrondal; Anders...............................................................79

Tompa; Peter.....................................................................31

Robinson; Peter N.............................................................72

Sleeman; B.D....................................................................89

Torres; Monica S...............................................................13

Roboz; John......................................................................60

Smith; David S..................................................................46

Tran; H.T..........................................................................89

Rockett; Bernard...............................................................34

Smith; Michael..................................................................36

Trevors; Jack T...................................................................16

Rockette; Howard.............................................................74

Smith; Ronald D...............................................................88

Tu; Xin M.........................................................................74

Rodgman; Alan.................................................................31

Smolke; Christina.............................................................57

Tu; Yu-Kang......................................................................88

Rodriguez; Raymond L.....................................................29

Soboyejo; Winston O........................................................60

Tuchin; Valery V................................................................46

Rosales; Romer..................................................................51

Solaiman; Daniel...............................................................37

Tyler; Christopher W.........................................................49

Rosenberger; Thad A...........................................................4

Sorensen; Helle.................................................................80

Rossi; John J......................................................................19

Spark; Arlene.....................................................................28

Rossmann; Jenn Stroud.....................................................46

Spehner; Daniele...............................................................58

Roy; Michael J..................................................................54

Splinter; Robert.................................................................53

Rucker; Robert B..............................................................27

Srivatsa; G. Susan..............................................................56

Ruppert; David.................................................................81

Stafstrom; Carl E...............................................................20

Russ; John C.....................................................................50

Stamatakos; Georgios S.....................................................90

Ruvinsky; Anatoly.............................................................71

Stanaszek; Mary J..............................................................69

Stanaszek; Walter F............................................................69

Sahoo; Prasanna K............................................................50

Stefanski; Leonard A.........................................................81

Salerno; Reynolds M.........................................................15

Stergiopoulos; Stergios......................................................49

Samuelsson; Gunnar.........................................................65

Strandberg; Kenneth M....................................................68

Sankar; Raman..................................................................20

Straub; John E...................................................................31

Stec; A. A..........................................................................32

Ugbolue; Samuel C. O......................................................41 Ulijaszek; Stanley................................................................6 Unger; Ron.......................................................................88

V Vafai; Kambiz....................................................................48 Vaidyanath; K...................................................................56 Valentine; David L............................................................36 Valentine; Raymond C......................................................36 Valero; Daniel...................................................................29 Valiente; Gabriel...............................................................70 Van Eeckhaut; Ann...........................................................58

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van Elsas; Jan Dirk............................................................16 van Gestel; Cornelis A. M.................................................33 Varsavsky; Andrea.............................................................21 Venn; Richard F.................................................................37 Verbeke; Geert..................................................................81 Verdier; Claude.................................................................89 Vidhyasekaran; P...............................................................14 Vilano; Jason.....................................................................11 Vinciotti; Veronica............................................................73 von Heijne; N.G.H. . .......................................................30

X Xian; Wujing.....................................................................39 Xu; Qing-Song..................................................................57 Xu; Rensheng....................................................................68 Xu; Tao.............................................................................55 Xu; Xie George.................................................................45

Y Yakovlev; Vladislav............................................................34 Yalkowsky; Samuel H........................................................35 Yasukouchi; Akira...............................................................6

Wallace; Mark Thomas.....................................................21 Wang; Edwin....................................................................70 Wang; Hansheng...............................................................87 Wang; Jason T.L................................................................70 Wang; Lihong V................................................................51 Wang; Perry G..................................................................65 Watanabe; Tsuneo.............................................................17 Watson; Ronald Ross......................................25, 26, 27, 28 Webb; Saxby.....................................................................51 Webster; John G...............................................................47 Weichbrod; Robert H.......................................................12 Weiner; Daniel..................................................................68 Welch; Kathleen B............................................................81 Wellek; Stefan...................................................................85 Welsh; Michael J...............................................................56 West; Brady T....................................................................81 Westfall; Peter...................................................................83 Wheeler; Matthew B.........................................................55 White Jr.; James F..............................................................13 Whitman; Douglas ............................................................7 Wichers; Harry J.................................................................8 Wienke; Andreas...............................................................78 Wiklund; Michael.............................................................41 Wildman; Robert E.C.......................................................26 Wiley; James B. . ..............................................................76

Ye; Yang............................................................................68 Yeagle; Philip L...................................................................4 Yildiz; Fatih.......................................................................33 Yoganathan; Ajit P.............................................................42 Yoganathan; Alit P.............................................................42 Yona; Golan......................................................................30 Yoneyama; Takayuki..........................................................41

Author Index

Wagstaff; D. Jesse..............................................................32

Zaccone; Giacomo .........................................................4, 6 Zalups; Rudolfs K...............................................................3 Zaveri; Hitten...................................................................21 Zchori-Fein; Elinat............................................................15 Zehnacker; Anne...............................................................52 Zeiger; Errol......................................................................33 Zempleni; Janos..........................................................24, 27 Zhang; Hao.......................................................................83 Zhang; Helen H................................................................56 Zhang; Hua......................................................................14 Zhang; Sam.......................................................................38 Zhao; Weimin...................................................................68 Zhu; Michael Xl................................................................24 Zorko; Matjaz...................................................................30 Zou; Kelly H.....................................................................74 Zouridakis; George.....................................................44, 45 Zuckerman; Daniel M......................................................53

Wilkinson; Darren J..........................................................74 Williams; Lawerence E......................................................66 Wilson; M.........................................................................26 Wit; Ernst.........................................................................73 Witten; Mark L.................................................................33 Wittung-Stafshede; Pernilla...............................................19 Wolinsky; Ira.....................................................................29 Wood; Andrew W.............................................................48 Wood; Bernard A................................................................7 Wood; Simon N................................................................78 Woodward; Mark..............................................................87 Woodward; Phil................................................................75 Wszolek; Zbigniew K........................................................23 Wu; Joseph C. . ..................................................................4 Wu; Lang..........................................................................82 Wu; William.....................................................................56

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101

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CRC Press • Taylor & Francis • Chapman & Hall/CRC • Auerbach Publications • Productivity Press • A K Peters

Visit us online at

www.crcpress.com

In the Americas Sales Office - CRC Press 6000 Broken Sound Parkway, NW, Suite 300, Boca Raton, FL 33487, U.S.A. Within the Continental USA - Tel: 800-272-7737 • Fax: 800-374-3401 • orders@taylorandfrancis.com Outside the Continental USA - Tel: 561-994-0555 • Fax: 561-361-6018 • international.orders@taylorandfrancis.com

Senior Vice President of Sales

Dennis Weiss Tel: 561-998-2510 Fax: 561-998-2580 e-mail: dennis.weiss@taylorandfrancis.com

Sales Agents

Customer Service

Angela Williams Tel: 800-272-7737 ext. 6091 Fax: 800-374-3401 e-mail: angela.williams@taylorandfrancis.com

Latin American Sales

Director of Sales Operations

Michael Dulisse Tel: 561-998-2582 Fax: 561-361-6049 e-mail: michael.dulisse@taylorandfrancis.com

Academic Sales

Retail Bookstores/ Premium/Custom Sales

Ryan Prior Tel: 561-998-2516 Fax: 561-361-6049 e-mail: ryan.prior@taylorandfrancis.com

Evelyn Elias Tel: 561-361-6010 Fax: 561-361-6049 e-mail: evelyn.elias@taylorandfrancis.com

Libraries

Susie Carlisle Tel: 561-998-2538 Fax: 561-361-6049 e-mail: susie.carlisle@taylorandfrancis.com

Subsidiary Rights Sales

Evelyn Elias Tel: 561-361-6010 Fax: 561-361-6049 e-mail: evelyn.elias@taylorandfrancis.com

Jennifer Strong Tel: 212-216-7851 Fax: 212-244-1563 e-mail: jennifer.strong@taylorandfrancis.com

Milton Park Sales Office - Taylor & Francis Group (Books Ltd) 2 Park Square, Milton Park, Abingdon, Oxon, OX14 4RN, UK

Group Sales Director

Academic Representatives (UK)

China Liaison Office

Customer Services

Christoph Chesher Tel: +44 (0) 20 7017 6194 Fax: +44 (0) 20 7017 6748 e-mail: christoph.chesher@tandf.co.uk

Tim Page Higher Education Sales Manager Mobile: 07824 690646 e-mail: tim.page@tandf.co.uk

Book orders should be addressed to the appropriate overseas agent or the Customer Service Department at Bookpoint:

International Sales Director

International Enquiries

Graham Crossley Tel: +44 (0) 20 7017 6048 Fax: +44 (0) 20 7017 6748 e-mail: graham.crossley@tandf.co.uk

Joanne Blackford International Sales Support Manager (Books) Tel: +44 (0) 20 7017 6053 Fax: +44 (0) 20 7017 6748 e-mail: joanne.blackford@tandf.co.uk

Yan Pei Manager Taylor & Francis Room 523 Resource Building No. 151 North Street Zhongguancun Beijing, China 100080 P.O. Box: 8762 Tel/Fax: +86 (10) 58876523 e-mail: yanpei@tandf.co.sg

Foreign Rights

Standing Orders

Head of UK Sales Nick Perry Tel: +44 (0) 20 7017 6132 Fax: +44 (0) 20 7017 6732 e-mail: nick.perry@tandf.co.uk

Corporate and Institutional Sales

102

Alfred Lea Tel: +44 (0) 20 7017 6273 Fax: +44 (0) 20 7017 6732 e-mail: cis@tandf.co.uk

UK Sales Support Executive Judith Cavell Tel: +44 (0) 20 7017 6191 Fax: +44 (0) 20 7017 6732 e-mail: judith.cavell@tandf.co.uk

Central and South America and Mexico Michael Dulisse Sales Office, Boca Raton, FL Taylor & Francis 6000 Broken Sound Parkway, NW, Suite 300, Boca Raton, FL 33487, USA Tel: 561-998-2582 Fax: 561-361-6049 e-mail: michael.dulisse@taylorandfrancis.com Ethan E. Atkin Cranbury International LLC 7 Clarendon Ave, Suite 2 Montpelier, VT 05602, USA Tel: +1 802 223 6565 Fax: +1 802 223 6824 e-mail: eatkin@cranburyinternational.com

European and Japanese Enquiries

Adele Parker Rights Manager e-mail: adele.parker@tandf.co.uk

Lucy Astone International Sales Support Coordinator Exhibitions Tel: +44 (0) 20 7017 6149 Katie Gilbert Fax: +44 (0) 20 7017 6748 Exhibitions Manager e-mail: lucy.astone@tandf.co.uk Tel: +44 (20) 7017 6310 South Asian, Middle Eastern and e-mail: katie.gilbert@tandf.co.uk

Taylor & Francis Bookpoint 130 Milton Park, Abingdon, Oxon OX14 4SB Tel: +44 (0) 1235 400 524 Fax: +44 (0) 1235 400 525 e-mail (UK): uktrade@tandf.co.uk e-mail (international): international@tandf.co.uk If you would like to receive books on our improved preselective standing order system, or if you would like to have further information about this service, please contact your area manager or Customer Services Department.

African Enquiries

Reanna Young International Sales Support Coordinator Tel: +44 (0) 20 7017 6114 Fax: +44 (0) 20 7017 6748 e-mail: reanna.young@tandf.co.uk

Caribbean and The West Indies

New Zealand

Middle East and North Africa

Jasmina Basic Area Sales Manager Milton Park Sales Office Tel: +44 (0) 20 7017 6187 Fax: +44 (0) 20 7017 6748 e-mail: jasmina.basic@tandf.co.uk

Macmillan Publishers NZ Ltd Victoria Johnson 6 Ride Way, Albany, Auckland, NZ Tel: +64 9414 0350 Fax: +64 9414 0357 e-mail: vicki@macmillan.co.nz

Australasia

Australia and New Zealand

Jasmina Basic Area Sales Manager – Middle East and Africa Milton Park Sales Office Tel: +44 (0) 20 7017 6187 Fax: +44 (0) 20 7017 6748 e-mail: jasmina.basic@tandf.co.uk Zoe Kaviani IPS (Middle East) Ltd P.O. Box 27533 Dubai, UAE Tel: +971 4 282 8801 Fax: +971 4 282 8804 e-mail: itpme@emirates.net.ae Website: http://www.ipsme.com

Joanne Blackford Milton Park Sales Office Tel: +44 (0) 20 7017 6053 Fax: +44 (0) 20 7017 6748 e-mail: joanne.blackford@tandf.co.uk

Australia Palgrave Macmillan Level 1, 15-19 Claremont Street, South Yarra Melbourne, Vic 3141, Australia Tel: +61 3 9825 1111 Fax: +61 3 9825 1010 e-mail: palgrave@macmillan.com.au www.palgravemacmillan.com.au

CRC Press and Marcel Dekker only Libraries may wish to order from their local bookseller, Palgrave Macmillan or DA Information Services Pty Ltd 648 Whitehorse Road, Mitcham Victoria, Australia Tel: +61 3 9210 7804 Fax: +61 3 9210 7788 www.dadirect.com.au

Australia Europa Publications (non-exclusive) James Bennett 3 Narabang Way, Belrose, NSW 2085 Australia Tel: +02 9986 7064 Fax: +02 9986 7030 www.bennett.com.au

Rest of Africa Jasmina Basic Area Sales Manager – Middle East and Africa Milton Park Sales Office

Korea

Chinke Ojiji Publishers Support Services Ltd Plot 2 Adewunmi Estate Oregun Road (Near First Bank Oregun) PO Box 9270, Ikeja, Lagos State Tel: +234 1 774 1073 Fax: +234 1 493 0419

Se-Yung Jun ICK (Information & Culture Korea) 473-19 Seokyo-dong, Mapo-ku Seoul, Korea 121-842 Tel: +82 2 3141-4791 Fax: +82 2 3141-7733 e-mail: cs.ick@ick.co.kr

Botswana Arthur Oageng Book Promotions/Horizon Books Botswana Gaborone International Finance Park Plot 113-114, Unit 33, Kgale Mews 2, Suite 3 Gaborone, Botswana Tel: +267 393 1194 Fax: +267 392 4908 e-mail: arthur.oageng@online.co.bw

South Africa, Namibia, Lesotho and Swaziland Michelle Symington Book Promotions Ltd BMD Office Park, 108 De Waal Road Diep River, 7800 Cape Town South Africa Tel: +27 21 707 5700 General Fax: +27 21 707 5795 Orders Fax: +27 21 707 5794 e-mail: enquiries@bookpro.co.za

South Asia Ryan Cooper Area Sales Manager Milton Park Sales Office Tel: +44 (0) 20 7017 6113 Fax: +44 (0) 20 7017 6748 e-mail: ryan.cooper@tandf.co.uk

India Taylor & Francis Books India Pvt Ltd. 912 Tolstoy House 15-17, Tolstoy Marg New Delhi 110 001 Tel: +91 (0) 11 2371 2131 +91 (0) 11 2335 1453 Fax: +91 (0) 11 2371 2132 e-mail: inquiry@tandfindia.com

Pakistan M. Anwer Iqbal Book Bird Mian Chambers, 3 Temple Road PO Box 518, Lahore, Pakistan Tel: +92 42 636 7275 Fax: +92 42 636 1370 e-mail: bookbird@brain.net.pk

Sri Lanka Nirosha Saravanapavan e-mail: niroshas@sltnet.lk Mobile: 0094 714 750911

Japan Hans Van Ess Book Sales and Marketing Executive Taylor & Francis Group 7F Koshin Bldg. 2-23-4 Kanda-Jimbocho Chiyoda, Tokyo 101-0051, Japan Tel: +81 (0) 3 5848 7061 Mobile: +81 (0) 80 5426 3552 e-mail: hans.vaness@informa.com United Publishers Services Limited 1-32-5 Higashi-shinagawa Shinagawa-ku, Tokyo 140-0002 Tel: +81 (0) 3 5479 7251 Fax: +81 (0) 3 5479 7307 e-mail: info@ups.co.jp Editorial Office Takahiko Kaneko Edition Synapse Yamaguchi Bldg. 3F 2-8-5 Uchikanda Chiyoda-Ku, Tokyo 101 0047, Japan Tel: +81 (0) 3 5296 9186 Fax: +81 (0) 3 3252 1822 e-mail: edsynapse@nifty.ne.jp

East and Southeast Asia For all Taylor & Francis Group imprints please order from our Singapore Sales Office Singapore Sales Office Taylor & Francis Asia Pacific 240 MacPherson Road #08-01 Pines Industrial Building Singapore 348574 Tel: +65 6741 5166 Fax: +65 6742 9356 e-mail: sales@tandf.com.sg

Malaysia and Brunei

David Yeong General Manager Taylor & Francis Publishing Services Taylor & Francis Asia Pacific No. 23-2, Jalan PJS 8/18 Dataran Mentari 46150 Petaling Jaya Selangor Darul Ehsan Malaysia Tel: +60 (3) 5630 1361 Fax: +60 (3) 5630 1732 Mobile: +60 (0)16 331 9912 e-mail: david.yeong@tandf.com.sg

Singapore, Philippines and Indonesia

Francis Chua, Sales Manager Singapore Sales Office e-mail: francis.chua@tandf.com.sg

Vietnam

Jeffrey Lim, Books Sales Director Singapore Sales Office e-mail: jeffrey.lim@tandf.com.sg

Hong Kong

Israel and the Palestinian Territories Ryan Cooper Area Sales Manager Milton Park Sales Office Tel: +44 (0) 20 7017 6113 Fax: +44 (0) 20 7017 6748 e-mail: ryan.cooper@tandf.co.uk and Rodney Franklin Franklin’s International PO BOX 3772 7, Tel Aviv 61376, Israel Tel: +972 356 00724 Fax: +972 356 00479 e-mail: rodneyf@netvision.net.il

Europe Peter Havinga European Sales Manager A. Hofmanweg 5a, 2031 BH Haarlem The Netherlands Tel: +31 (0) 23 750 5730 Fax: +31 (0) 23 750 5701 Mobile: +31 (0) 6 515 69560 e-mail: peter.havinga@tandf.co.uk

Belgium, The Netherlands, France and Luxembourg Liza Walraven Sales Representative A. Hofmanweg 5a, 2031 BH Haarlem The Netherlands Tel: 0031 (0) 23 750 5731 Fax: 0031 (0) 23 750 5701 Mobile: 0031 (0) 6 238 49668 e-mail: liza.walraven@informa.com

Taylor & Francis Asia Pacific Room 903, Resource Building No.151 North Street Zhongguancun, Beijing, China 100080 Tel/Fax: +86 (10) 58876903 Jeffrey Lim, Books Sales Director e-mail: jeffrey.lim@tandf.com.sg Cynthia Ji, Sales & Marketing Executive e-mail: cynthia.ji@tandf.com.sg

Shanghai Region

Chris Ye, Senior Sales Executive Tel: +86 135 64618686 e-mail: chris.ye@tandf.com.sg

Daphne Edwards Area Representative Mobile: 07802 536 233 Tel: +44 (0) 20 7017 6259 e-mail: daphne.edwards@tandf.co.uk

Oxfordshire, West Midlands and South Wales John Blake Area Representative Mobile: 07889 263 857 Fax: 01242 228 691 e-mail: john.blake@tandf.co.uk

North and Northwest England Lucy Greaves Area Representative Mobile: 07860 633156 Fax: 01663 746682 e-mail: lucy.greaves@tandf.co.uk

London (EC, SE, SW, W and WC) Charlotte Westgate Area Representative Mobile: 07917 648040 e-mail: charlotte.westgate@tandf.co.uk Nick Pepper Area Representative Tel: 01434 250331 Mobile: 07825 748476

Nordic Countries

Conor Graham / Michael Darcy Brookside Publishing Services 2 Brookside, Dundrum Road, Dublin 14 Tel: 00 353 1 298 9937 Fax: 00 353 1 298 7912 e-mail: sales@brookside.ie

Germany, Austria and Switzerland

China

Southern England

Scotland and North of England

Thailand

Taylor & Francis Asia Pacific Tel: +886 (2) 2578 6106 ext.125 Fax: +886 (2) 2578 6507 Jeffrey Lim, Books Sales Director e-mail: jeffrey.lim@tandf.com.sg Sara Cheng, Sales Executive e-mail: sara.cheng@tandf.co.uk

Bob Davis Senior Area Representative Mobile: 07889 263 856 Fax: 01621 819 833 e-mail: bob.davis@tandf.co.uk

Ryan Cooper Area Sales Manager Milton Park Sales Office Tel: +44 (0) 20 7017 6113 Fax: +44 (0) 20 7017 6748 e-mail: ryan.cooper@tandf.co.uk

Taylor & Francis Asia Pacific Tel: +852 91796613 Jeffrey Lim, Books Sales Director e-mail: jeffrey.lim@tandf.com.sg Jolly Chan, Account Manager e-mail: jolly.chan@tandf.com.sg

Taiwan

London (East, Northwest, North) and Eastern England

Greece

Lisa Hetherington Sales Representative Taylor & Francis Drottensgatan 2 222 23 Lund, Sweden Mobile: +46762220300 e-mail: lisa.hetherington@tandf.co.uk

Taylor & Francis Asia Pacific Tel: +66 (2) 6427954-6 ext. 406 Fax: +66 (2) 6427677 Jeffrey Lim, Books Sales Director e-mail: jeffrey.lim@tandf.com.sg Nonglak Sawaithong, Sales Executive e-mail: s.nonglak@tandf.com.sg

England and Wales

Gabriela Mauch Area Sales Manager

Taylor & Francis Group (Books Ltd)

Anna-Peters-Str. 49 70597 Stuttgart, Germany Tel: +49 (0)711 7207231 Fax: +49 (0)711 7220668 Mobile +49 (0)173 9059469 e-mail: gabriela.mauch@tandf.co.uk

Spain, Portugal, and Italy Philip Veysey Area Sales Manager Príncipe de Vergara 109, 28002 Madrid, Spain Tel: +34 91 700 0688 Fax: +34 91 141 2304 Mobile: +34 68 777 3678 e-mail: philip.veysey@informa.com

Eastern Europe Marek Lewinson (Humanities and Social Sciences) Bohaterewicza 3/45 03-982 Warsaw, Poland Tel/fax: +48 (0) 22 6714819 Mobile: +48 (0) 602 707 037 e-mail: mlewinso@it.com.pl Radek Janousek (Science and Technology) Pod Nouzovem 972/21 197 00 Prague, Czech Republic Tel: +42 (0) 28 658 49888 Mobile: +42 (0) 602294014 e-mail: radek@mareklewinson.com

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Library Supply Nigel Berkeley Library Supply and London Key Accounts Manager Mobile: 07795 968206 e-mail: nigel.berkeley@tandf.co.uk

Online Retailers Rod Abraham Assistant UK Sales Manager Mobile: 07860 380 814 Fax: 01372 273 744 e-mail: rod.abraham@tandf.co.uk

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