BIOENGINEERING and BIOTECHNOLOGY by CRC Press

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New and Noteworthy Textbooks for Your

BIOENGINEERING and BIOTECHNOLOGY Courses

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Contents Bio Signals and Systems ........................................3 Biomechanics ........................................................9 Bio MEMS, NEMS, and Materials ........................11 Biomedical Imaging ............................................17 Biophysics ............................................................18 Page 3

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Biotechnology ......................................................20 General Textbooks ..............................................26

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Bio Signals and Systems

New!

Analysis and Application of Analog Electronic Circuits to Biomedical Instrumentation Second Edition Robert B. Northrop University of Connecticut, Storrs, USA

This textbook helps biomedical engineers understand the basic analog electronic circuits used for signal conditioning in biomedical instruments. It explains the function and design of signal conditioning systems using analog ICs—the circuits that enable ECG, EEG, EMG, ERG, tomographic images, biochemical spectrograms, and other crucial medical applications. The text demonstrates how op amps are the keystone of modern analog signal conditioning system design and illustrates how they can be used to build instrumentation amplifiers, active filters, and many other biomedical instrumentation systems and subsystems. It introduces the mathematical tools used to describe noise and its propagation through linear systems, and it looks at how signal-to-noise ratios can be improved by signal averaging and linear filtering.

Features • Analyzes the properties of photonic sensors and emitters and the circuits that power them • Details the design of instrumentation amplifiers and medical isolation amplifiers • Considers the modulation and demodulation of biomedical signals • Examines analog power amplifiers, including power op amps and class D (switched) PAs • Describes wireless patient monitoring, including Wi-Fi and Bluetooth communication protocols • Explores RFID, GPS, and ultrasonic tags and the design of fractal antennas • Addresses special analog electronic circuits and systems such as phase-sensitive rectifiers, phase detectors, and IC thermometers By explaining the "building blocks" of biomedical systems, the author illustrates the importance of signal conditioning systems in the devices that gather and monitor patients’ critical medical information.

What’s New in This Edition • Updated and revised material throughout • A chapter on the applications, circuits, and characteristics of power amplifiers • A chapter on wireless patient monitoring using UHF telemetry • A chapter on RFID tags, GPS tags, and ultrasonic tags • A glossary to help you decode the acronyms and terms used in biomedical electronics, physiology, and biochemistry • New end-of-chapter problems and examples that emphasize biomedical electronic applications

Pedagogical Features • An extensive glossary • End-of-chapter problems and examples Solutions manual available with qualifying course adoption

Selected Contents Sources and Properties of Biomedical Signals. Properties and Models of Semiconductor Devices Used in Analog Electronic Systems. The Differential Amplifier. General Properties of Electronic, SingleLoop Feedback Systems. Feedback, Frequency Response, and Amplifier Stability. Operational Amplifiers and Comparators. Introduction to Analog Active Filters. Instrumentation and Medical Isolation Amplifiers. Noise and the Design of Low-Noise Signal Conditioning Systems for Biomedical Applications. Digital Interfaces. Modulation and Demodulation of Biomedical Signals. Power Amplifiers and Their Applications in Biomedicine. Wireless Patient Monitoring. RFID Tags, GPS Tags, and Ultrasonic Tags Used in Ecological Research. Examples of Special Analog Circuits and Systems Used in Biomedical Instrumentation. Appendix. Glossary. Bibliography and Recommended Reading. March 2012, 578 pp. ISBN: 978-1-4398-6669-6, £76.99

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Bio Signals and Systems Signals and Systems Analysis in Biomedical Engineering Second Edition

Introduction to Complexity and Complex Systems

Robert B. Northrop

University of Connecticut, Storrs, USA

The interdisciplinary field of biomedical engineering requires its practitioners to know and master not only engineering skills, but also a diversity of material in the biological sciences. This textbook helps biomedical engineering students and professionals strengthen their skills in the network of applied mathematics that ties together these diverse disciplines. Based on the author's 30 years of experience in teaching as well as his personal research on neurosensory systems, this book, now in its second edition, provides a ready source of information on the specialized mathematical techniques most useful in describing and analyzing biomedical signals.

Written for students and professionals in the fields of biomedical engineering, systems biology, biophysics, and physiology, this unique reference covers complexity issues within living systems. Topics include human responses to coping with complex systems, the Law of Unintended Consequences, the relation of complexity to evolution, the complexity inherent in invertebrate immune systems, and the complexity inherent in economic systems. A comprehensive glossary provides acronyms and terms relating to complex, nonlinear biological systems. Dynamic models and homework questions are also included to further aid in understanding.

• Focuses on the mathematical tools required to analyze and describe the signals and systems found in biomedical engineering

• Describes the characteristics of certain complex living systems

• Includes a comprehensive chapter on joint timefrequency analysis of nonstationary biomedical signals, and the use of wavelets in JTFA • Explores the mathematics of tomographic imaging • Describes the analytical signal and the Hilbert transform • Discusses the analysis of nonlinear systems, nonlinear oscillators, and biological clocks • Introduces the analysis of and modeling strategies for complex systems Solutions manual available with qualifying course adoption

Selected Contents Introduction to Biomedical Signals and Systems. Review of Linear Systems Theory. The Laplace Transform and Its Applications. Fourier Series Analysis of Periodic Signals. The Continuous Fourier Transform. The Discrete Fourier Transform. Introduction to Joint TimeFrequency Analysis of Biomedical Signals. Introduction to the Analysis of Stationary Noise, and Signals Contaminated with Noise. Basic Mathematical Tools Used in the Characterization of Physiological Systems. Introduction to the Mathematics of Tomographic Imaging. ...

• Provides dynamic models for various complex systems • Offers present-day examples for dealing with complex systems • Includes homework problems for better comprehension

Selected Contents Introduction to Complexity and Complex Systems. Introduction to Large Linear Systems. Introduction to Nonlinear Biochemical Systems and Biochemical Oscillators. Modularity, Redundancy, Degeneracy, Pleiotropy and Robustness in Complex Biological Systems. The Evolution of Biological Complexity; Invertebrate Immune Systems. The Complex Adaptive and Innate Human Immune Systems. Complexity in Quasispecies: MicroRNAs. Introduction to Physiological Complexity: Examples of Models of Some Complex Physiological Systems. The Quest for Quantitative Measures of Complexity. "Irreducible and Specified Complexity" in Living Systems. Introduction to Complexity in Economic Systems. Dealing with Complexity. Appendix. Bibliography and References. Glossary. Index. December 2010, 551 pp. ISBN: 978-1-4398-3901-0, £53.99

March 2010, 654 pp. ISBN: 978-1-4398-1251-8, £66.99

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Bio Signals and Systems

Biomedical Engineering Principles Second Edition Arthur B. Ritter, Vikki Hazelwood, and Antonio Valdevit Stevens Institute of Technology, Hoboken, New Jersey, USA

Alfred N. Ascione Alcatel-Lucent Technologies, New Jersey, USA

Praise for the Previous Edition “[Provides] not only an in-breadth overview on current BME fields, but also an in-depth analysis of specific selected topics that are supported by appropriate mathematical models, equations, quantitative data charts and tables.” —Biomedical Engineering Online

“... an excellent textbook for a class. Each chapter contains numerous examples and contains many figures to enhance learning. References and suggestions for further reading are included at the end of each chapter. Problems are included at the end of chapters, where they will best test the student's knowledge.” —Richard C. Fries, PE, CRE, Baxter Healthcare, Inc., in IEEE Engineering in Medicine and Biology Magazine

“... well illustrated with figures, schemes, various plots, and mathematical equations. This book will definitely be useful for biochemists, biophysicists, and specialists in cell biology and medicine.” —G. Ya. Wiederschain, Doctor of Biological Science, Moscow State University, Russia

Integrating engineering, medicine, biology, and physics, this book clearly defines basic principles in image processing and biomechanics, modeling physiological processes, and bioelectric signal analysis to build a solid understanding of devices and designs for improved functioning of the human body. It includes cutting-edge discussions of tissue engineering, cardiovascular components, bone regrowth, and nerve regeneration. Other topics include technologies at the forefront of cardiac care, such as total artificial hearts, left ventricular assist devices, and stents, as well as issues related to minimally invasive and robotic surgery, next-generation imaging devices, and nanodevices.

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• Includes new chapters on capstone design in biomedical engineering and entrepreneurship • Contains new coverage of systems biology and computational biology • Provides extensively revised and updated chapters on the emerging field of tissue engineering

Pedagogical Features • Offers extensive examples and in-chapter problems Solutions manual and figure slides available with qualifying course adoption

Selected Contents Introduction: Modeling of Physiological Processes. Cell Physiology and Transport. Principles and Biomedical Applications of Hemodynamics. A Systems Approach to Physiology. The Cardiovascular System. Biomedical Signal Processing. Signal Acquisition and Processing. Techniques for Physiological Signal Processing. Examples of Physiological Signal Processing. Principles of Biomechanics. Practical Applications of Biomechanics. Biomaterials. Principles of Biomedical Capstone Design. Unmet Clinical Needs. Entrepreneurship: Reasons why Most Good Designs Never Get to Market. An Engineering Solution in Search of a Biomedical Problem to Solve. Tissue Engineering. Future Trends in BME. May 2011, 540 pp. ISBN: 978-1-4398-1232-7, £63.99

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Bio Signals and Systems

Basic Transport Phenomena in Biomedical Engineering Third Edition Ronald L. Fournier University of Toledo, Ohio, USA

Encompassing a variety of engineering disciplines and life sciences, the very scope and breadth of biomedical engineering presents challenges to creating a concise, entry-level text that effectively introduces basic concepts without getting overly specialized in subject matter or rarified in language. Basic Transport Phenomena in Biomedical Engineering, Third Edition meets and overcomes these challenges to provide the beginning student with the foundational tools and the confidence they need to apply these techniques to problems of ever-greater complexity. Bringing together fundamental engineering and life science principles, this accessible text provides focused coverage of key momentum and mass transport concepts in biomedical engineering. It offers a basic review of units and dimensions, material balances, and problem-solving tips, and then emphasizes those chemical and physical transport processes that have applications in the development of artificial and bioartificial organs, controlled drug delivery systems, and tissue engineering. The book also includes a discussion of thermodynamic concepts and covers topics such as body fluids, osmosis and membrane filtration, and pharmacokinetic analysis. It concludes with the application of these principles to extracorporeal devices as well as tissue engineering and bioartificial organs. Designed for the beginning student, this book provides a quantitative understanding of the underlying physical, chemical, and biological phenomena involved. Encouraging students to work examples with the mathematical software package of their choice, this text provides them the opportunity to explore various aspects of the solution on their own, or apply these techniques as starting points for the solution to their own problems.

• Provides an introductory level text for students in bioengineering, chemical engineering, mechanical engineering, and the life sciences • Presents a basic understanding of the theories of transport in biological systems and then builds on this knowledge base to show real-world applications in the development and design of artificial organs, drug delivery systems, and tissue engineering • Contains an extensive bibliography of the research literature that supports the material in the text • Offers mathematical models using the “shell balance” or compartmental approaches

Pedagogical Features • Includes numerous examples with a discussion of the numerical methods used to solve the problems • Supplies homework problems at the end of each chapter Solutions manual available with qualifying course adoption

Selected Contents Introduction. A Review of Thermodynamic Concepts. Physical Properties of the Body Fluids and the Cell Membrane. The Physical and Flow Properties of Blood. Solute Transport in Biological Systems. Pharmacokinetic Analysis. Extracorporeal Devices. Tissue Engineering. Bioartificial Organs. Index. August 2011, 483 pp. ISBN: 978-1-4398-2670-6, £44.99

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Bio Signals and Systems

Introduction to Biomedical Engineering Technology Second Edition Laurence Street Rosedale, British Colombia, Canada

Equipment arrives for repair with a note saying, “Broken.” – What do you do? Medical devices are often very complex, but while there are differences in design from one manufacturer to another, the principles of operation and, more importantly, the physiological and anatomical characteristics on which they operate are universal. Introduction to Biomedical Engineering Technology, Second Edition explains the uses and applications of medical technology and the principles of medical equipment management to familiarize readers with their prospective work environment. Written by an experienced biomedical engineering technologist, the book describes the technological devices, various hardware, tools, and test equipment used in today’s healthcare arena. Photographs of representative equipment; the technical, physiological, and anatomical basis for their function; and where they are commonly found in hospitals are detailed for a wide range of biomedical devices, from defibrillators to electrosurgery units. Throughout, the text incorporates real-life examples of the work that biomedical engineering technologists do. Appendices supply useful information such as normal medical values, a list of regulatory bodies, Internet resources, and information on training programs. Thoroughly revised and updated, this second edition includes more examples and illustrations as well as end-of-chapter questions to test readers’ understanding. This accessible text supplies an essential overview of clinical equipment and the devices that are used directly with patients in the course of their care for diagnostic or treatment purposes. The author’s practical approach and organization, outlining everyday functions and applications of the various medical devices, prepares readers for situations they will encounter on the job.

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• Covers a wider range of devices and includes an expanded section on equipment management • Describes the day-to-day work of biomedical engineering technologists using extensive examples • Offers chapter summaries and questions to aid in reader comprehension • Contains more than 360 illustrations • Includes a 16-page grayscale insert with photographs of real-life equipment problems • Provides appendices listing normal medical values, biomedical associations, test equipment manufacturers, helpful Internet resources, and more Solutions manual available with qualifying course adoption

Selected Contents Introduction. Diagnostic Devices: Part One. Diagnostic Devices: Part Two. Diagnostic Devices: Part Three. Diagnostic Imaging. Treatment Devices: Part One. Treatment Devices: Part Two. Treatment Devices: Part Three. Biomedical Engineering Technologist (BMET) Work. Testers and Tools. Batteries, Radiation, and Computers. Technology Management. Appendix A: Normal Values. Appendix B: Regulations and Standards. Appendix C: Biomedical Engineering Technology Programs in the United States and Canada. Appendix D: Biomedical Associations. Appendix E: Devices and Manufacturers. Appendix F: Test Equipment Manufacturers. Appendix G: Bibliography and Internet Resources. Index. October 2011, 391 pp. ISBN: 978-1-4398-6058-8, £56.99

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Bio Signals and Systems

Biology for Engineers Arthur T. Johnson University of Maryland, College Park, USA

Biology is a critical application area for engineering analysis and design, and students in engineering programs must be well versed in the fundamentals of biology as they relate to their field. Biology for Engineers is an introductory text that minimizes unnecessary memorization of connections and classifications and instead emphasizes concepts, technology, and the utilization of living things. Whether students are headed toward a bio-related engineering degree or one of the more traditional majors, biology is so important that all engineering students should know how living things work and act. Classroom-tested at the University of Maryland, this comprehensive text introduces concepts and terminology needed to understand more advanced biology literature. Filled with practical detailed examples, the book presents: • Scientific principles relevant to biology that all engineers must know • A discussion of biological responses from the perspective of a broad range of fields such as psychology, human factors, genetics, plant and animal physiology, imaging, control systems, actuary, and medicine • A thorough examination of the scaling of biological responses and attributes

Features • Explores areas in physics, chemistry, mathematics, and engineering relating to biology • Introduces concepts and terminology needed to understand more advanced biology literature • Examines the differences between biological engineering and biological science • Includes a chapter on scaling relations showing how size affects other physical characteristics • Surveys a broad range of application areas Solutions manual available with qualifying course adoption

Selected Contents Introduction Principles from the Sciences: Principles of Physics. Principles of Chemistry. Principles of Mathematics and Engineering Sciences. Principles of Biology. Responses of Living Systems: Biological Responses in Context. Scaling Factors: Allometric Relationships from Evolutionary Pressure. Utilizing Living Systems: Systems Approach.

• A classification of different types of applications related to biological systems

Appendices. References. Index.

• Tables of useful information that are nearly impossible to find elsewhere

September 2010, 775 pp. ISBN: 978-1-4200-7763-6, £66.99

• A series of questions at the end of each chapter to test comprehension Emphasizing the ever-present interactions between a biological unit and its physical, chemical, and biological environments, the book provides ample instruction on the basics of physics, chemistry, mathematics, and engineering. It brings together all of the concepts one needs to understand the role of biology in modern technology.

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Biomechanics Biofluid Mechanics The Human Circulation, Second Edition Krishnan B. Chandran University of Iowa, Iowa City, USA

Stanley E. Rittgers University of Akron, Ohio, USA

Ajit P. Yoganathan Georgia Institute of Technology, Atlanta, USA

"... the book provides a good platform in fluid mechanics prior to progressing to the physiological applications which make it an appropriate textbook for BME students." —Professor Tim McGloughlin, Centre for Applied Biomedical Engineering Research and Department of Mechanical Aeronautical and Biomedical Engineering, University of Limerick

Designed for senior undergraduate or first-year graduate students in biomedical engineering, Biofluid Mechanics: The Human Circulation, Second Edition teaches students how fluid mechanics is applied to the study of the human circulatory system. Reflecting changes in the field since the publication of its predecessor, this second edition has been extensively revised and updated.

New to the Second Edition • Improved figures and additional examples • More problems at the end of each chapter • A chapter on the computational fluid dynamic analysis of the human circulation, which reflects the rapidly increasing use of computational simulations in research and clinical arenas Drawing on each author’s experience teaching courses on cardiovascular fluid mechanics, the book begins with introductory material on fluid and solid mechanics as well as a review of cardiovascular physiology pertinent to the topics covered in subsequent chapters. The authors then discuss fluid mechanics in the human circulation, primarily applied to blood flow at the arterial level. They also cover vascular implants and measurements in the cardiovascular system.

Features • Provides a classroom-tested textbook for a first course on fluid mechanics in human circulation, focusing on the heart and major arteries • Reviews fluid and solid mechanics and normal cardiovascular physiology • Explains how to model steady and unsteady flows • Evaluates the design and development of artificial heart valves, stent implants, and vascular grafts • Describes various considerations and approaches involved in the computational modeling of cardiovascular diseases and therapies • Includes end-of-chapter references and problems as well as numerous figures throughout that have been selected from the publications of many eminent researchers Solutions manual available with qualifying course adoption

Selected Contents Fluid and Solid Mechanics and Cardiovascular Physiology: Fundamentals of Fluid Mechanics. Introduction to Solid Mechanics. Cardiovascular Physiology. Biomechanics of the Human Circulation: Rheology of Blood and Vascular Mechanics. Static and Steady Flow Models. Unsteady Flow and Nonuniform Geometric Models. Native Heart Valves. Cardiovascular Implants, Biomechanical Measurements, and Computational Simulations: Prosthetic Heart Valve Dynamics. Vascular Therapeutic Techniques. Fluid Dynamic Measurement Techniques. Computational Fluid Dynamic Analysis of the Human Circulation. Index. February 2012, 451 pp. ISBN: 978-1-4398-4516-5, £66.99

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Biomechanics Biomechanics of the Upper Limbs Mechanics, Modeling and Musculoskeletal Injuries, Second Edition Andris Freivalds The Pennsylvania State University, University Park, USA

Over the past two decades, the growth in computerrelated jobs has led to considerable increase in the number of work-related musculoskeletal disorders in the upper limbs. Now in its second edition, Biomechanics of the Upper Limbs: Mechanics, Modeling and Musculoskeletal Injuries is expanded to include recent findings regarding job stressors and a variety of ergonomic solutions. Using the author’s medical and engineering expertise to distill essential subject matter and useful technical data, this textbook explores: • Biomechanics of the upper limbs and the motor control system • The structure and physiology of the human musculoskeletal and neuromuscular systems • Recent research findings and solutions to various ergonomic problems • Models of various components of the neuromuscular systems, as well as larger systems in the upper limbs • Risk factors for disorders and tools used to identify their causes

Biomechanics and Exercise Physiology Quantitative Modeling Arthur T. Johnson University of Maryland, College Park, USA

Using numerous worked examples to demonstrate what and when to calculate, this text covers more than just the fundamentals of exercise physiology. It demonstrates the vast amount of physiological material that can be quantitatively predicted and describes how to translate this information into applications. The book examines the energetics of exercise, biomechanics, circulation, respiration, and thermoregulation, and includes numerical examples and homework problems. With an emphasis on quantitative description, it includes tables and illustrations which make this book helpful for estimating magnitudes, determining trends, and illustrating concepts. • Covers how to quantitatively predict exercise thermal response, using metric units • Addresses respiratory models, cardiovascular models, and thermal models • Demonstrates exactly how equations and methods are applied with worked quantitative examples • Provides mathematical equations you can use to predict physiological responses

Pedagogical Features

• Includes tables of physiological variable values for estimating normal responses and building models

• Provides numerous examples in each chapter

• Presents models that contain precise information

• Features downloadable PowerPoint slides, sample exams, and other background material on a supporting website

• Discusses the mechanical approaches to the understanding of exercise, both from a static and from an dynamic viewpoint

• Includes an instructor's manual with complete solutions

Selected Contents

• Contains end-of-chapter references to enhance further study

Selected Contents Introduction to Biomechanics. Structure of the Musculoskeletal System. Neuromuscular Physiology and Motor Control. Modeling of Muscle Mechanics. Models of the Upper Limbs. Musculoskeletal Disorders and Risk Factors. Instrumentation. Job and Worksite Analysis. Hand Tools. The Office Environment. February 2011, 564 pp. ISBN: 978-1-4200-9119-9, £76.99

Exercise Limitations: Introduction. Exercise Intensity and Duration. Muscle Metabolism. ... Exercise Biomechanics: Introduction. Physics of Movement. Energy Cost of Movement. ... Cardiovascular Responses: Introduction. Cardiovascular Mechanics. Cardiovascular Control. ... Respiratory Responses: Introduction. Respiratory Mechanics. Control of Respiration. ... Thermal Responses: Introduction. Thermal Mechanics. Thermoregulation. ... Index Chapters include homework problems and references. March 2007, 688 pp. ISBN: 978-1-57444-906-8, £87.00

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Bio MEMS, NEMS, and Materials New!

A Laboratory Course in Tissue Engineering Melissa Kurtis Micou University of California, San Diego, USA

Dawn Kilkenny University of Toronto, Ontario, Canada

“The book is well organized to teach cell culture and tissue engineering experiments to novice and experienced students. There is a quantitative emphasis in the book that strengthens the ‘engineering’ part of tissue engineering.” —Ann Saterbak, Rice University, Houston, Texas, USA

A hands-on lab manual for tissue engineering instruction, this book contains 15 standalone experiments based on both classic and modern approaches. Experiments encompass a set of widely applicable techniques: cell culture, microscopy, histology, immunohistochemistry, mechanical testing, soft lithography, and common biochemical assays. In addition to these specific techniques, the experiments emphasize engineering analysis, mathematical modeling, and statistical experimental design. To minimize lab costs, experiments use equipment commonly found in labs equipped for tissue culture.

Pedagogical Features • Contains standalone experiments, allowing instructors to customize their courses • Includes prelab and postlab questions for each experiment • Includes more than 70 illustrations A Solutions manual, available with qualifying course adoption, includes answers to pre- and postlab questions, suggested equipment suppliers and product numbers, and other resources to help plan a new tissue engineering course

Selected Contents Getting Started in the Lab. Lab Safety. Essential Lab Skills for Tissue Engineers. Isolation of Primary Chondrocytes from Bovine Articular Cartilage. Measuring and Modeling Growth of a Cell Population. Purification of a Cell Population Using Magnetic Cell Sorting. Decellularized Matrices for Tissue Engineering. Effect of Plating Density on Cell Adhesion to Varied Culture Matrices. Dynamic versus Static Seeding of Cells onto Biomaterial Scaffolds. Cell Patterning Using Microcontact Printing. Measuring and Modeling the Motility of a Cell Population Using an Under-Agarose Assay. Characterizing Matrix Remodeling Through Collagen Gel Contraction. Effect of Substrate Stiffness on Cell Differentiation. ...

New!

Introduction to BioMEMS Albert Folch University of Washington, Seattle, USA

“The field has been waiting for a true textbook that provides a practical, historical, authoritative and comprehensive introduction to bioMEMS. It has finally arrived, courtesy of Albert Folch, complete with PowerPoint lectures and thoughtful homework questions. I highly recommend it.” —David J. Beebe, University of Wisconsin–Madison

“... a monumental achievement which brings an authoritative and comprehensive account to the rapidly growing, multidisciplinary field of bioMEMS.” —Mehmet Toner, Helen Andrus Benedict Professor of Bioengineering, Harvard Medical School

“It provides a visual feast of images that lead to a comprehensive understanding of many complex concepts. Applications presented range from biomolecules to cells, tissues, and organisms, and are presented in clear, logical steps. It serves as an outstanding text for advanced undergraduates and graduate students, as well as an excellent review for researchers who are new to the field.” —Dr. Fawwaz Habbal, Harvard University

Pedagogical Features • Highlights fundamental concepts and defines them in an extensive glossary • Includes over 400 color figures, problem sets, design challenges, and key references • Offers downloadable PowerPoint slides for instructors

Selected Contents How Do We Make Small Things? Micropatterning of Substrates and Cells. Microfluidics. Molecular Biology on a Chip. Cell-Based Chips for Biotechnology. BioMEMS for Cell Biology. Tissue Microengineering. Implantable Microdevices. Appendix. Index. August 2012, 528 pp. ISBN: 978-1-4398-1839-8, £57.99

August 2012, 304 pp., Soft Cover ISBN: 978-1-4398-7893-4, £38.99

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Bio MEMS, NEMS, and Materials

A Textbook for Your Lectures... An Introduction to Biomaterials Second Edition Edited by

Jeffrey O. Hollinger Carnegie Mellon University, Pittsburgh, Pennsylvania, USA

A practical road map to the key families of biomaterials and their potential applications in clinical therapeutics, An Introduction to Biomaterials, Second Edition follows the entire path of development from theory to lab to practical application. It highlights new biocompatibility issues, metrics, and statistics as well as new legislation for intellectual property. Divided into four sections, this dramatically revised edition includes both new and revised chapters on cells, tissues, and signaling molecules in wound healing cascades, as well as two revised chapters on standardized materials testing with in vitro and in vivo paradigms consistent with regulatory guidelines. Emphasizing biocompatibility at the biomaterial-host interface, it investigates cell-cell interactions, cell-signaling and the inflammatory and complement cascades, specific interactions of protein-adsorbed materials, and other inherent biological constraints including solid-liquid interfaces, diffusion, and protein types. Unique in its inclusion of the practicalities of biomaterials as an industry, the book also covers the basic principles of statistics, U.S. FDA information on the biomaterials-biology issues relevant to patent applications, and considerations of intellectual property and patent disclosure. With nine completely new chapters and 24 chapters extensively updated and revised with new accomplishments and contemporary data, this comprehensive introduction discusses 13 important classes of biomaterials, their fundamental and applied research, practical applications, performance properties, synthesis and testing, potential future applications, and commonly matched clinical applications. Contains end-of-chapter questions and answers. Solutions manual available with qualifying course adoption. November 2011, 644 pp. ISBN: 978-1-4398-1256-3, £48.99

Selected Contents Consensus Definitions, Fundamental Concepts, and a Standardized Approach to Applied Biomaterials Sciences. Biology, Biomechanics, Biomaterial Interactions: Wound Healing Biology: Cutaneous Wound Pathobiology: Raison d’etre for Tissue Engineering. Osseous Wound Healing. Biology, Biomechanics, Biomaterial Interactions: Cellular Mechanics: Cell and Tissue Mechanobiology. Biology, Biomechanics, Biomaterial Interactions: Materials–Host Interactions: Cell–Material Interactions: Fundamental Design Issues for Tissue Engineering and Clinical Considerations. Host Response to Biomaterials. Protein Adsorption at the Biomaterial–Tissue Interface. Biomaterials Testing, Statistics, Regulatory Considerations, Intellectual Property: Standardized Materials Testing: In Vitro Testing of Biomaterials. Assessment of Biomaterials: Standardized In Vivo Testing. Biomaterials Testing, Statistics, Regulatory Considerations, Intellectual Property: Statistics: Basic Principles of Statistics: Considerations for Biomaterials Engineers. Therapy Development, Animal Testing, and Regulatory Issues. Fundamentals of Patenting for the Biomaterials Scientist. Biomaterials Compositions: Proteins and Amino Acid–Derived Polymers. ThreeDimensional Fibrin Constructs in Tissue Engineering. Biomedical Polyurethanes. Polymers Derived from l-Tyrosine. Poly(propylene Fumarate). Complex Polysaccharides: Chitosan and Alginate. Collagen: A Natural Biomaterial for Tissue Engineering. Polyphosphazenes. Biologically Active Glasses. Silk-Based Biomaterials: Biology, Properties, and Clinical Applications. Calcium-Based Bioceramics: Biology, Properties, and Clinical Applications. Biomaterials Applications: Tissue Engineering of Skin. Polymeric Biomaterials for Drug and Nucleic Acid Delivery. Orthopedic Prostheses and Joint Implants. Bone and Biomaterials. Functional Regeneration of Synovial Joints In Vivo: The Role of Biomaterials and Scaffold Design. Tissue Engineering, Biomaterials, and the Nervous System. Ligaments, Biomaterials, and Tissue-Engineering Opportunities. Cardiovascular Tissue Engineering and Biomaterials. Index.

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Bio MEMS, NEMS, and Materials

...and One for Your Lab Courses

A Laboratory Course in Biomaterials Wujing Xian University of Illinois at Urbana-Champaign, USA

The field of biomedical engineering has vastly expanded in the past two decades, as reflected in the increased number of bioengineering and biomaterials programs at universities. The growth of this area has outpaced the development of laboratory courses that allow students hands-on experience, since the barriers involved in creating multidisciplinary biomaterials laboratory courses are high. A Laboratory Course in Biomaterials provides a teaching tool comprehensive in scope perspective.

Pedagogical Features

Multidisciplinary approach

• Includes text boxes with in-depth information, case studies, and lab tips

Suitable for junior- or senior-level laboratory courses in biomaterials and bioengineering, this volume trains students in laboratory skills, data analysis, problem solving, and scientific writing. The text takes a multidisciplinary approach, integrating a variety of principles that include materials science, chemistry, biochemistry, molecular and cell biology, and engineering.

Step-by-step instructions The author presents flexible modules that allow the coursework to be adapted to the needs of different departments. Each module is organized around a central theme, such as drug delivery and natural biomaterials, to enhance student comprehension. This book provides step-by-step descriptions of lab procedures, reagents, equipment, and data processing guidelines. It also includes a series of thought-provoking questions and answers following each experiment, drawn from the author’s own experience in teaching a biomaterials laboratory course at the University of Illinois.

• Presents detailed, step-by-step descriptions of lab procedures and explanations for the underlying principles • Contains user-friendly graphic illustrations for the experiments • Provides a series of questions and answers at the end of each chapter to clarify concepts and induce critical thinking

• Offers information on equipment, reagents, and supplies for instructors

Selected Contents Basic Laboratory Skills. Module I. Drug Delivery: Controlled Release of Encapsulated Protein from PLGA Microspheres. Module II. Natural Biomaterials: Collagen and Chitosan. Basic Laboratory Skills II. Cell Culture and Microscopy. Module III. Biocompatibility Testing: Cytotoxicity and Adhesion. Module IV. Tissue Engineering: Organotypic Cultures of Skin Equivalents. Module V. Bioceramics: Porous Hydroxyapatite Composite. Appendix: Answers. Index. June 2009, 216 pp., Soft Cover ISBN: 978-1-4200-7582-3, £41.99

Timely in its coverage, many of the experiments presented in the book are adapted from research papers reflecting the progress in various disciplines of bioengineering and biomaterials science.

For more information and complete contents, visit

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Bio MEMS, NEMS, and Materials

From MEMS to Bio-MEMS and Bio-NEMS Manufacturing Techniques and Applications Marc J. Madou University of California, Irvine, USA

From MEMS to Bio-MEMS and Bio-NEMS: Manufacturing Techniques and Applications details manufacturing techniques applicable to bionanotechnology. After reviewing MEMS techniques, materials, and modeling, the author covers nanofabrication, genetically engineered proteins, artificial cells, nanochemistry, and self-assembly. He also discusses scaling laws in MEMS and NEMS, actuators, fluidics, and power and brains in miniature devices. He concludes with coverage of various MEMS and NEMS applications. Fully illustrated in color, the text contains end-of-chapter problems, worked examples, extensive references for further reading, and an extensive glossary of terms.

Details the Nanotechnology, Biology, and Manufacturing Techniques Applicable to Bionanotechnology Topics include: • Nonlithography manufacturing techniques with lithography-based methods

Other volumes in the set include: • Solid-State Physics, Fluidics, and Analytical Techniques in Micro- and Nanotechnology • Manufacturing Techniques for Microfabrication and Nanotechnology

Features • Focuses on applications of NEMS and MEMS • Covers scaling laws, actuators, and fluidics • Discusses top-down and bottom-up manufacturing methods • Explains how to use nature as a guide

Pedagogical Features • End-of-chapter problems • Worked-out problems within the text • Extensive references for further reading

• Nature as an engineering guide and contrasts top-down and bottom-up approaches

• A comprehensive glossary of terms

• Packaging, assembly, and self-assembly from ICs to DNA and biological cells

Solutions manual, PowerPoint lecture slides, and electronic figures available with qualifying course adoption

• Color illustrations throughout

• Selected new MEMS and NEMS processes and materials, metrology techniques, and modeling • Scaling laws, actuators, power generation, and the implementation of brains in miniaturizes devices • Different strategies for making micromachines smarter • The transition out of the laboratory and into the marketplace The third volume in Fundamentals of Microfabrication and Nanotechnology, Third Edition, Three-Volume Set, the book discusses topdown and bottom-up manufacturing methods and explains how to use nature as a guide. It provides a better understanding of how to match different manufacturing options with a given application that students can use to identify additional killer MEMS and NEMS applications.

Selected Contents From Traditional Manufacturing to Nanotechnology: Nonlithography-Based (Traditional) and LithographyBased (Nontraditional) Manufacturing Compared. Nature as an Engineering Guide: Biomimetics. Nanotechnology: Top-Down and Bottom-Up Manufacturing Approaches Compared. Packaging, Assembly, and Self-Assembly. Selected Materials and Processes for MEMS and NEMS. Metrology and MEMS/NEMS Modeling. Scaling Laws, Actuators, and Power and Brains in Miniature Devices: Scaling Laws. Actuators. Power and Brains in Miniature Devices. Miniaturization Application: MEMS and NEMS Applications. June 2011, 650 pp. ISBN: 978-1-4200-5516-0, £63.99

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Bio MEMS, NEMS, and Materials

BioMEMS Science and Engineering Perspectives Simona Badilescu and Muthukumaran Packirisamy Concordia University, Montreal, Canada

As technological advancements widen the scope of applications for biomicroelectromechanical systems (BioMEMS or biomicrosystems), the field continues to have an impact on many aspects of life science operations and functionalities. Because BioMEMS research and development require the input of experts who use different technical languages and come from varying disciplines and backgrounds, scientists and students can avoid potential difficulties in communication and understanding only if they possess a skill set and understanding that enables them to work at the interface of engineering and biosciences. Keeping this duality in mind throughout, BioMEMS: Science and Engineering Perspectives supports and expedites the multidisciplinary learning involved in the development of biomicrosystems. Divided into nine chapters, it starts with a balanced introduction of biological, engineering, application, and commercialization aspects of the field. With a focus on molecules of biological interest, the book explores the building blocks of cells and viruses, as well as molecules that form the self-assembled monolayers (SAMs), linkers, and hydrogels used for making different surfaces biocompatible through functionalization.

The book also discusses: • Different materials and platforms used to develop biomicrosystems • Various biological entities and pathogens (in ascending order of complexity) • The multidisciplinary aspects of engineering bioactive surfaces

Features • Provides a concise overview of BioMEMS principles • Incorporates modern applications • Covers fabrication techniques

Pedagogical Features • Examples and problems in each chapter • References, review questions, and case studies to aid with reader application Solutions manual available with qualifying course adoption

Selected Contents Introduction. Substrate Materials Used in BioMEMS Devices. Biomolecules and Complex Biological Entities: Structure and Properties. Engineering of Bioactive Surfaces. Methods of Study and Characterization of Surface-Modified Substrates. Biosensing Fundamentals. Fabrication of BioMEMS Devices. Introduction to Microfluidics. BioMEMS: Life Science Applications. April 2011, 368 pp. ISBN: 978-1-4398-1699-8, £63.99

• Engineering perspectives, including methods of manufacturing bioactive surfaces and devices • Microfluidics modeling and experimentation • Device level implementation of BioMEMS concepts for different applications Because BioMEMS is an application-driven field, the book also highlights the concepts of lab-on-a-chip (LOC) and micro total analysis system (µTAS), along with their pertinence to the emerging point-of-care (POC) and point-of-need (PON) applications.

For more information and complete contents, visit

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Bio MEMS, NEMS, and Materials

Biomaterials A Nano Approach

Biomedical Microsystems University of Southern California, Los Angeles, USA

Seeram Ramakrishna, Murugan Ramalingam, T.S. Sampath Kumar, and Winston O. Soboyejo

Written by an active researcher named one of Technology Review’s Young Innovators Under 35, this book begins with an introduction to the benefits of miniaturization. It introduces materials, fabrication technology, and the necessary components of all bioMEMS. The author covers fundamental principles and building blocks, including microfluidic concepts, lab-on-a-chip systems, and sensing and detection methods. The final chapters explore several important applications of bioMEMS, such as microdialysis, catheter-based sensors, MEMS implants, neural probes, and tissue engineering. Detailed examples, exercises, and illustrations help clarify the concepts.

From a multi-disciplinary point of view, this book examines basic concepts, various processing methodologies, and techniques involved in the preparation and characterization of nanobiomaterials that are specific to biomedical applications. It spans their historical development and reviews recent advances in the field. It describes how basic concepts in nanotechnology are applied to the processing of novel nanobiomaterials, including nanostructured metals and alloys. Presenting illustrative examples and a variety of applications, this text offers a solid framework for understanding present and future trends of biomaterials in human health care systems.

Features

June 2010, 372 pp. ISBN: 978-1-4200-4781-3, £69.99

Ellis Meng

• Presents a rigorous, in-depth treatment of bioMEMS materials, methods, processes, and concepts • Emphasizes practical knowledge useful for application to real-world problems • Describes research and commercialized bioMEMS devices as well as emerging applications

Pedagogical Features • Detailed examples, laboratory exercises, and a variety of homework problems • Numerous illustrations of concepts, processes, and devices • Downloadable original images for qualifying instructors at www.crcpress.com Solutions manual available with qualifying course adoption

Selected Contents Introduction. BioMEMS Materials. Microfabrication Methods and Processes for BioMEMS. Microfluidics. Lab-on-a-Chip or Micro Total Analysis Systems. Sensing and Detection Methods. Applications to Cells, Nucleic Acids, and Proteins. Clinical Monitoring. MEMS Implants and Bioelectric Interfaces. Index. September 2010, 408 pp. ISBN: 978-1-4200-5122-3, £59.99

New!

Understanding Nanomedicine An Introductory Textbook Rob Burgess Medical Nanotechnologies Incorporated, Richardson, Texas, USA

Understanding Nanomedicine: An Introductory Textbook comprehensively covers a broad range of therapeutic and diagnostic applications of nanotechnology, providing descriptions of cutting-edge discoveries along with historical perspectives. The text focuses on nanomaterials and nanoparticles, the sectors that hold the most promise for the future of medicine. The author looks at how nanotechnology can impact cancer treatment, clinical neuroscience, tissue engineering, drug delivery, and diagnostics. He also discusses the worldwide governmental regulatory impact on nanomedicine. June 2012, 524 pp. ISBN: 978-981-4316-38-5, £95.00

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Biomedical Imaging Biomedical Signal and Image Processing

New Edition of a Bestseller!

Webb's Physics of Medical Imaging Second Edition

Second Edition

Edited by

Kayvan Najarian

M.A. Flower

Virginia Commonwealth University, Richmond, VA, USA

Institute of Cancer Research/Royal Marsden NHS Foundation Trust, UK

Robert Splinter University of North Carolina at Charlotte, USA

Praise for the Bestselling First Edition “... the text of choice for teaching graduate research students in this new and exciting subspeciality of physics.” —Physics Today

“… a worthwhile addition to the personal library of anyone connected with this field.” —Journal of Clinical Physics and Physiological Measurement

“For all those requiring a comprehensive review of medical imaging techniques, at a fairly basic level, this text is highly recommended.” —Australian Physicist

Since the publication of the bestselling first edition, the technology and clinical applications of medical imaging have changed significantly. Gathering these developments into one volume, this comprehensive second edition presents the basic physics, modern technology, and up-to-date examples of clinical application across all the modalities of medical imaging. It now covers state-of-the-art detector technology and computer processing used in medical imaging. Along with many new examples and figures, this edition includes new chapters on medical image processing and multimodality imaging. Contains more than 400 high-quality figures, with some in color

"... a great introduction to the topic, while it also includes advanced topics in the field for graduate courses. … highly recommended to any research and educator in this field." —Purang Abolmaesumi, Department of Electrical Engineering, University of British Columbia, Canada

"The authors’ ability to introduce concepts at the level appropriate for senior undergraduate or graduate-level students is impressive. ... I would definitely use this book as my textbook in a biomedical signal-processing course." —Shahram Shirani, McMaster University, Canada

"… an excellent bridge between the physiological significance of the methods, and the underlying mathematics. … clear, well written, and easy to follow. … this is an excellent course textbook." —Dr. Kristian Sandberg, Computational Solutions, Inc., USA

This textbook describes fundamental signal and image processing techniques used to process biomedical information. It also discusses application of these techniques in the processing of some of the main biomedical signals and images, such as EEG, ECG, MRI, and CT. New features include the technical updating of each chapter along with the addition of many more examples, the majority of which are MATLAB® based. Solutions manual available with qualifying course adoption

Selected Contents

In the Beginning: The Origins of Medical Imaging. Diagnostic Radiology with X-Rays. X-Ray Transmission Computed Tomography. Clinical Applications of X-Ray Computed Tomography in Radiotherapy Planning. Radioisotope Imaging. Diagnostic Ultrasound. Spatially Localised Magnetic Resonance. Physical Aspects of Infrared Imaging. Imaging of Tissue Electrical Impedance. Optical Imaging. Mathematics of Image Formation and Image Processing. Medical Image Processing. Perception and Interpretation of Images. ...

Introduction to Digital Signal and Image Processing: Signals and Biomedical Signal Processing. Fourier Transform. Image Filtering, Enhancement, and Restoration. Edge Detection and Segmentation of Images. Wavelet Transform. Other Signal and Image Processing Methods. Clustering and Classification. Processing of Biomedical Signals: Electrical Activities of Cell. Electrocardiogram. Electroencephalogram. Electromyogram. Other Biomedical Signals. Processing of Biomedical Images: Principles of Computed Tomography. X-Ray Imaging and Computed Tomography. Magnetic Resonance Imaging. Ultrasound Imaging. Positron Emission Tomography. Other Biomedical Imaging Techniques. Related Titles. Index.

June 2012, 864 pp. ISBN: 978-0-7503-0573-0, £49.99

May 2012, 411 pp. ISBN: 978-1-4398-7033-4, £63.99

Selected Contents

For more information and complete contents, visit

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Biomedical Imaging Applied Medical Image Processing A Basic Course Wolfgang Birkfellner Associate Professor, Department of Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria

“The topics covered are clearly explained, including explanations of the mathematical operations that are required, therefore making it an ideal text for anyone who is new to medical image processing.” —Sarah Cade, Scope, December 2011

“The CD adds substantial value to the text and serves as an excellent guide to practice the information covered in the text. … Students who take a course where this book is used as the course text will be fortunate indeed.” —William Hendee, Medical Physics, December 2010

Biophysics New!

Ultrasonic and Electromagnetic NDE for Structure and Material Characterization Engineering and Biomedical Applications Edited by

Tribikram Kundu The University of Arizona, Tucson, USA

“... an essential reference for researchers and graduate students ... The different chapters contributed by recognized experts in the field cover both fundamental theory as well as current research areas.” —Dr. Paul Fromme, University College London, UK

“... a lucid, well-written, and hands-on textbook that explains in simple terms and with examples the basic issues of medical image processing.”

“... a comprehensive and rigorous approach of the fundamentals of linear and nonlinear ultrasonics and electromagnetic methods, including a chapter on the newly emerging THz technique. The book also provides enough advanced engineering and biological applications to make the reader familiar with these technologies ... an excellent text for a senior/first-year graduate course in nondestructive testing and evaluation, or as a text in a course in engineering and biological materials characterization.”

—Professor Leo Joskowicz, Head of Computer-Assisted Surgery and Medical Image Processing Laboratory, The Hebrew University of Jerusalem

—Henrique Reis, Department of Industrial and Enterprise Systems Engineering, University of Illinois at Urbana-Champaign, USA

“... an outstanding work ... Relevant medical images used for processing complement many of the concepts discussed.” —Edward J. Ciaccio, Columbia University, BioMedical Engineering OnLine, 2011

“... a perfect blend of theory and practice. I highly recommend it.” —Dr. Pascal Fallavollita, Technische Universität München

Pedagogical Features • Includes questions, problems, and worked-out examples • Contains more than 640 illustrations

Selected Contents A Few Basics of Medical Image Sources. Image Representation. Operations in Intensity Space. Segmentation. Filtering and Transformations. Spatial Transforms. Rendering, Visualization, and Surface Models. Registration. Volume Reconstruction. Appendix. Glossary. Index. September 2010, 403 pp. ISBN: 978-1-4398-2444-3, £45.99

Solutions manual and figure slides to enhance classroom PowerPoint presentations available with qualifying course adoption

Selected Contents Mechanics of Elastic Waves and Ultrasonic Nondestructive Evaluation. Modeling of Ultrasonic Fields by Distributed Point Source Method. Electromagnetic Nondestructive Evaluation. Distributed Point Source Method for Imaging in Electrostatic and Electromagnetic Problems. Guided Waves for Plate and Pipe Inspection. Fundamentals and Applications of Nonlinear Ultrasonic Nondestructive Evaluation. Theory and Applications of Laser Ultrasonic Techniques. . ... June 2012, 890 pp. ISBN: 978-1-4398-3663-7, £95.00

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Biophysics Quantitative Understanding of Biosystems

New!

An Introduction to Biophysics

Molecular Motors in Bionanotechnology

Thomas M. Nordlund

Keith Firman and James Youell

University of Alabama at Birmingham, USA

“This terrific text offers a broad range of learning opportunities for many undergraduate majors. ... It will enable students to understand the significance of biological parameters through quantitative examples—a modern way of learning biophysics. —American Journal of Physics, February 2012

“... a beautiful review of essential physics for understanding biological systems, particularly at the molecular scale, emphasizing that which is rarely taught in standard physics classes: how to think like a physicist.” —Ernest Barreto, George Mason University

“A superb pedagogical textbook.”

University of Portsmouth, UK

This textbook describes a wide range of molecular motors, ranging from chemical motors to biological motors, in a manner that updates, or reviews, both classification of the type of motor and the grouping into families. Many techniques have evolved to study and characterize molecular motors at the single-molecule level, and readers are introduced to the concepts and benefits of each technique. In addition, the book looks at structural information and how this helps understand function and, finally, how some of these motors are being used or may be used in the future. August 2012, 300 pp. ISBN: 978-981-4267-02-1, £95.00

—Midwest Book Review, May 2011

An accompanying CD includes a wealth of interactive material. Solutions manual and presentation-quality diagrams available with qualifying course adoption. March 2011, 583 pp. ISBN: 978-1-4200-8972-1, £57.99

Dynamics of Biological Systems Michael Small

New!

Physical Chemistry for Engineering and Applied Sciences Frank R. Foulkes This textbook is the result of more than 30 years of teaching by the author of a one-semester course in physical chemistry to first-year students at the University of Toronto. The book is unique in that it provides the detailed development of the equations, which can be followed relatively easily even with only moderate mathematical skills and backgrounds. The book provides interesting and inspiring examples, as well as many problems and solutions.

Hong Kong Polytechnic University

With exercises and projects in each chapter, this classroomtested text shows how to apply a variety of mathematical and computational techniques to model and analyze the temporal and spatial phenomena of biological systems. The mathematical models and computer simulations offer insight into cardiac pacemakers, artificial electrical defibrillation, pandemics, pattern formation, flocking behavior, the interaction of autonomous agents, and hierarchical and structured network topologies. MATLAB® implementations of algorithms and case studies are available on the author’s website. Solutions manual available with qualifying course adoption August 2011, 284 pp. ISBN: 978-1-4398-5336-8, £49.99

August 2012, 675 pp. ISBN: 978-1-4665-1846-9, £57.99

For more information and complete contents, visit

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Biophysics Physics for Diagnostic Radiology

Biotechnology

Biotechnology Operations

Third Edition

Principles and Practices

P.P. Dendy Addenbrookes NHS Trust, Cambridge, UK

Michael J. Roy

B. Heaton

University of Wisconsin-Madison, USA

Aberdeen Radiation Protection Services, UK

“This is the third edition of a well-established and popular textbook on physics of diagnostic radiology. ... written in a clear and concise style, supported by excellent illustrations. ... describes recent state-ofthe-art advances in medical imaging in a way radiologists, radiographers and medical physicists will find easy to understand. It is internationally recognised as one of the key textbooks in its field.” —Dr. Keith Faulkner, North East Strategic Health Authority, UK

Fully revised and updated, this bestselling text helps readers understand how various imaging techniques work. Exercises, multiple choice questions, extensive references, and further reading aid in understanding. August 2011, 720 pp. ISBN: 978-1-4200-8315-6, £49.99

Physiology, Biophysics, and Biomedical Engineering Edited by

Andrew W. Wood Swinburne University of Technology, Hawthorn, Victoria, Australia

Showing how biophysics and biomedical engineering have advanced modern medicine, this text provides a multidisciplinary understanding of biological phenomena and the instrumentation for monitoring these phenomena. It also explores the application of physics and engineering methods to medicine and biology. The book includes a range of numerical problems with worked solutions and offers MATLAB® code for advanced mathematical analysis of physiological and clinical monitoring systems. Solutions manual available with qualifying course adoption

Because of rapid developments in the biotechnology industry—and the wide range of disciplines that contribute to its collective growth—there is a heightened need to more carefully plan and fully integrate biotech development projects. Despite the wealth of operations experience and associated literature available, no single book has yet offered a comprehensive, practical guide to fundamentals. Filling the void, Biotechnology Operations: Principles and Practices reflects this integrative philosophy, serving as a practical guide for students, professionals, or anyone else with interests in the biotech industry. Although many books emphasize specific technical aspects of biotech, this is perhaps the first to integrate essential concepts of product development and scientific and management skills with the seven functional areas of biotechnology. A practical roadmap to optimizing biotechnology operations, this reference illustrates how to use specific product planning, design, and project management processes to seamlessly merge plans and efforts in the key functional areas. Applying lessons learned throughout the nascent history of biotech, author Michael Roy highlights developmental principles that could bring future products to market more safely and efficiently. Drawing from his experiences working in industry and teaching a graduate course at the University of Wisconsin, this hotly anticipated book clarifies basic methodologies and practices to help reduce risks and resolve problems as future technological discoveries are developed into tangible products.

Selected Contents Introduction to Biotechnology Operations: Planning for Success. Project Management. Regulatory Affairs. Regulatory Compliance. Quality Systems. Biomanufacture. Quality Control. Nonclinical Studies. Clinical Trials. Glossary. Additional Reading. Practical Problems and Questions. March 2011, 416 pp. ISBN: 978-1-4398-3027-7, £63.99

February 2012, 782 pp. ISBN: 978-1-4200-6513-8, £49.99

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Biotechnology

Coming Soon!

Learning Bio-Micro-Nanotechnology Mel I. Mendelson Loyola Marymount University, Los Angeles, California, USA

A primary text for undergraduate nanotechnology courses, this book is designed for students who lack a cross-disciplinary background and knowledge of micro- and nano-technology. Clearly and concisely written, it contains many examples, questions, and problems divided into three hierarchical learning skills: understanding, analyzing, and evaluating the concepts. The author attempts to break down the boundaries between biology, chemistry, physics, engineering and ethics. He accomplishes this by co-mingling the vocabulary and concepts of these disciplines around bio-applications. Copiously illustrated, this new text leans heavily towards biological and biomedical applications and includes a comprehensive chapter on ethics. • Breaks down the barriers between biology, chemistry, physics, engineering, and ethics with cross-disciplinary coverage • Emphasizes ethics throughout the text • Includes extensive references at the end of each chapter Solutions manual available with qualifying course adoption October 2012, c. 614 pp. ISBN: 978-1-4200-8203-6, £57.99

Selected Contents Thinking Small and Big: Introduction. Bit of Technology History. Tera-to-Pico Multipliers. Size of Things. What Is "Small Technology?" Memory Lane in Electronics. Applications. Biomolecules and Cells: Introduction. Science of Evolution. Powers of "10" Revisited. Building a Human Cell. Biomolecules. Protein Folding. Identifying Biomolecules. Forensic Methods. Genetic Variation: Mutations. Molecular Chemistry: Introduction. Periodic Table. Some Chemical Definitions. Chemical Bonding. Macromolecules. Polymer Examples. Colloids. Solid Nanomolecules. Bit of Physics: Introduction. Size Matters. Working toward the Bottom. Definitions at the Bottom. Bottom: Energy Levels and Bonding. Benefits at the Bottom. Engineering Bits and Bytes: Introduction. Electronicson-a-Chip. Computer Applications. Control Systems. Seeing Small Things: Introduction. Human Eye. Some Microscope Definitions. Light Microscopes. Electron Microscopes. Nanoelectronics: Introduction. Computer Applications. Lithographic Tools. Recent Chip Developments. Emerging Technology. Bottom-Up Technology. Microelectromechanical Systems: Introduction. Overview. Microsensors. Microactuators. Biochips. Nanotechnology and Cancer: Introduction. What Is Cancer? Discovery: L. Detection: I. Delivery: T. Destruction: R. Risks: Nano or Mega?: Introduction. Bit of Anatomy. Definitions Relating to Risk. Chemical and Physical Factors. Benefits versus Risks. Risk Assessment. Risk Management. Ethics and Social Relevance: Introduction. Some Ethics Definitions. Ethics Algorithm. Some Ethical Issues. Self-Assembled Future: Introduction. Definition: SelfAssembled Future. Geometric Proportions. Chemical Assembly. Snow Flake Assembly. Self-Assembled Colloids. Linear-Step Assembly. Spiral-Step Assembly. Amphiphilic Structures. Biomolecular Assembly. Self-Assembled Monolayers. Some Future Predictions. Epilogue. Appendices. Index. Chapters also include key concepts, questions and problems, and references.

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Biotechnology

New!

Introduction to Instrumentation in Life Sciences Prakash S. Bisen Defense Research & Development Establishment, Gwalior, India

Anjana Sharma Rani Durgavati University, Jabalpur, India

Designed to serve a multitude of students and researchers diversified in the field of life sciences, pharmacy, biotechnology, microbiology, biochemistry, and environmental sciences, this book addresses the different aspects of instrumentation that hold the key for cutting-edge research and innovative application. The authors emphasize techniques encountered both in the practical classes and also in high throughput techniques involved in the modern era of commercialization and product inventories. It includes wellillustrated diagrams to explain the principles and theories behind these instruments. • Provides a comprehensive overview of techniques and usage of key instrumentation needed in biotechnology and life sciences • Contains unique coverage of chromatography and spectroscopy • Includes a CD with color illustrations • Supplies exercises at the end of each chapter

Selected Contents Microscopy: Magnification, Resolution, and Contrast. Light (Bright Field) Microscopy. Dark Field Microscope. Phase Contrast Microscope. Interference Microscope. UV and Fluorescence Microscopes. Electron Microscopy. Tunneling Electron Microscopy. Confocal Microscopy. Techniques in Microscopy. Electron Microscopy. Micrometry: Structure of an Ocular Micrometer. Conjugate Image-Forming Focal Planes. Eyepiece Designs. Stage Micrometer. Filar Eyepiece Micrometer. Principle of Filar Eyepiece Micrometer. Working. Electrochemical Techniques: Structure of a pH Meter. Principles. Factors Limiting the Accuracy of pH Measurements. Measurement of pH. Working. Procedure for Measuring pH Using a pH Meter. Cleaning and Troubleshooting of Glass Probes. Application of pH Measurements. Oxygen Electrode. Chromatography: General Principles. Column Chromatography. Paper Chromatography and ThinLayer Chromatography. Sample Collection, Preservation, and Preparation. Adsorption Chromatography. Partition Chromatography. HighPerformance Liquid Chromatography. Fast Protein Liquid Chromatography. Gas–Liquid Chromatography. Ion-Exchange Chromatography.

Exclusion Chromatography. Affinity Chromatography. Spectroscopy: UV–Visible Spectroscopy. IR (Vibrational) Spectroscopy. Flame/Atomic Absorption Spectroscopy. Fluorescence Spectroscopy. ESR Spectroscopy. NMR Spectroscopy. MALDI-TOF Mass Spectrometry. Circular Dichroism (CD) Spectroscopy. Centrifugation: Principle of Centrifugation. Types of Centrifuges. Types of Centrifugal Separations. Rotor Categories. Selection of Centrifuge Tubes. Common Centrifugation Vocabulary and Formulas. Analytical Ultracentrifuge. Electrophoresis: Principles of GE. Working with the Electrophoresis Apparatus. Denaturing Gradient GE. Temperature Gradient GE. Pulsed-Field GE. Capillary Electrophoresis. X-Ray Microanalysis: Principles. Instrumentation. Applications of X-Ray Microanalysis. Techniques for the Analysis of Secondary, Tertiary, and Quaternary. Proteins by X-Ray Crystallography. Techniques with Radioisotopes: Isotopes and Radioactivity. Ionization Effects. Measurement Units. Measurement Techniques. Autoradiography. Counting Statistics. Biological Uses of Radioisotopes. Tracer Dilution Technique. Radioimmunoassay. Miscellaneous Uses of Radioisotopes. Radioisotope Production. Most Widely Used Radioisotopes. Fermentation: History. Principles of Fermentation. Introduction to Microorganisms. Types of Fermentation Metabolism. Fermentation Process. Types of Fermentation. Types of Fermentors. Sterilization in Fermentation. Product Recovery. Conductivity Meters: Principles. Common Definitions. Conductivity Meter. Conductivity Cells. Factors Influencing the Measurement. Measuring Techniques. Reliable Measurements. Maintenance and Storage. Applications. Glossary Index Chapters include an introduction, suggested readings, and important links. September 2012, 392 pp. Soft Cover, ISBN: 978-1-4665-1240-5 £49.99

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Biotechnology

Biotechnology Fundamentals Firdos Alam Khan Manipal University, Dubai, UAE

The focus of Biotechnology Fundamentals is to educate readers on both classical and modern aspects of biotechnology and to expose them to a range of topics, from basic information to complex technicalities. Other books cover subjects individually, but this text offers a rare topical combination of coverage, using numerous helpful illustrations to explore the information that students and researchers need to intelligently shape their careers.

Features • Includes information on current research trends • Covers novel medical genetics topics such as intra-uterine insemination • Discusses the process of biotech product development, with suitable examples

Keeping pace with the rapid advancement of the field, topics covered include:

• Examines ethical issues within biotechnology research and product development (e.g. embryonic stem cells, cloning, gene therapy, and GM crops)

• How biotechnology products are produced

Pedagogical Features

• Differences between scientific research conducted in universities and industry

• Learning objectives for each chapter

• Which areas of biotechnology offer the best and most challenging career opportunities • Key laboratory techniques and protocols employed in the field The contents of this book are derived from discussions between teachers and undergraduate students and designed to address the concepts and methods thought useful by both sides. Starting with the fundamentals of biotechnology, coverage includes definitions, historical perspectives, timelines, and major discoveries, in addition to products, research and development, career prospects, ethical issues, and future trends. The author explains that even before it had been classified as its own field, biotechnology was already being applied in plant breeding, in vitro fertilization, alcohol fermentation, and other areas. He then delves into new developments in areas including stem cell research, cloning, biofuels, transgenic plants, genetically modified food/crops, pharmacogenomics, and nanobiotechnology. Incorporating extensive pedagogy into the content, this book provides plenty of examples, end-of-chapter problems, case studies, and lab tutorials to help reinforce understanding.

For more information and complete contents, visit

• Problems, lab assignments, references, and ancillary online resources • Suggestions for field trips that can be used to apply and better understand concepts and other material in the book Solutions manual available with qualifying course adoption

Selected Contents Introduction to Biotechnology. Genes and Genomics. Proteins and Proteomics. Recombinant DNA Technology. Microbial Biotechnology. Agricultural Biotechnology. Animal Biotechnology. Environmental Biotechnology. Medical Biotechnology. Nanobiotechnology. Product Development in Biotechnology. Industrial Biotechnology. Ethics in Biotechnology. Careers in Biotechnology. Laboratory Tutorials. Glossary. September 2011, 608 pp. ISBN: 978-1-4398-2009-4, £48.99

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Biotechnology

Healthcare Biotechnology A Practical Guide

Environmental Microbiology for Engineers

Dimitris Dogramatzis

Volodymyr Ivanov

Dogramatzis Pharmacy, Athens, Greece

Nanyang Technological University, Singapore

"... The section on marketing is also particularly strong and well thought through. ... provides insight into the biotechnology business sector."

Designed specifically for engineers with little or no biology training, this textbook covers diversity and function of microorganisms in environmental engineering systems, environmental bioengineering processes, applied microbial genetics and molecular biology, microbiology of water and wastewater treatment, biotreatment and bioremediation, and microbial monitoring. It also explores biocorrosion of the constructions, biodeterioration of the materials, biocementation and bioclogging of soil, biopollution of indoor environment, and biofouling of the facilities.

—British Journal of Biomedical Science

Focusing on the management of health-care related biotechnology, this text is a practical guide assisting all healthcare-related biotech professionals in their dayto-day activities. It contains chapters on bioeconomy, biolicensing, biofinance, biopartnering, biodrug research, biomarket planning, biopromotion, product life cycle management, and biobusiness models. Written by a well-established professional and registered pharmacist, this reference is appropriate for graduate students and industry professionals. It contains over 350 tables and figures and end-of-section problems accompany each chapter. Extensive references follow each chapter. • Provides end-of-chapter problems and appropriate essays for each subject covered • Offers a practical step-by-step guide for both graduate students and industry professionals • Offers many illustrations, including over 350 tables and figures • Contains extensive references at the end of each chapter as well as three appendices to enhance further study

• Combines microbiological knowledge and environmental biotechnology principles in a readable fashion for environmental and civil engineers • Discusses ‘hot’ topics in the area such as environmental bionanotechnology, microbial geotechnology, and environmental engineering of closed microbial ecosystems

Pedagogical Features • Contains a glossary of terms • Supplies a quiz and tutorial questions at the end of each chapter • Teaches with minimal use of mathematical equations Solutions manual available with qualifying course adoption

Selected Contents The Healthcare Biotechnology Industry: Bioeconomy. Intellectual Property: Intellectual Property Management. Biolicensing. Funding: Biofinance. Biopartnering. New Product Development: Biodrug Research. Biomanufacturing. Marketing: Biomarketing planning. Biopromotion. Biopricing. Biosupply Chain. Product Life Cycle Management. Running the Business: Biobusiness models. Biosimilars Model. Biocompany Life Cycle. Appendices. December 2010, 689 pp. ISBN: 978-1-4398-4746-6, £66.99

Selected Contents Stages of Bioprocessing. Bioagents of Bioprocessing. Microbial Metabolism and its control. Molecular Biology and Genetics of Microorganisms. Selection of Pure Cultures. Classifications ad Identifications of Prokaryotes. Periodic Table of Physiological Groups of Prokaryotes. Nutrition and Growth. Cultivation of Microorganisms and Downstream Processes. Microbial Adaptations and Engineering Control. Microbial Natural Ecosystems. Microbial Engineering Ecosystems. Public Health Microbiology for Engineers. Microbiology of Water Treatment. Microbiology of Aquatic Ecosystems. Microbiology of Anaerobic Wastewater Treatment. Microbiology of Aerobic Wastewater Treatment. ... November 2010, 438 pp. ISBN: 978-1-4200-9234-9, £66.99

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Biotechnology Fundamentals of Microfluidics and Lab on a Chip for Biological Analysis and Discovery Paul C.H. Li Simon Fraser University, Burnaby, British Columbia, Canada

Authored by one of the field’s pioneering researchers, this volume focuses on all key aspects of the microfluidic lab-on-a-chip technologies to offer an exceptionally cohesive overview of the science, its limitations, breakthroughs made over the years, and currently emerging advances. The book emphasizes analytical applications of microfluidic technology and presents in-depth coverage of micromachining methods, microfluidic operations, chemical separations, sample preparation and injection methods, detection technology, and various chemical and biological analyses. Other topics of interest include the use of polymeric chips, fluid flow valve and control, single-cell analysis, DNA and RNA amplification techniques, DNA hybridization, immunoassays, and enzymatic assays.

Systems Biology and Bioinformatics A Computational Approach Kayvan Najarian, Christopher N. Eichelberger, Siamak Najarian, and Shahriar Gharibzadeh Emphasizing computational methods, Systems Biology and Bioinformatics provides an introduction to system biology and its impact on biology and medicine. It reviews basic principles of molecular and cell biology using a system-oriented approach, with a brief description of the high-throughput biological experiments that produce databases. The methods presented include techniques to discover genes, perform nucleotide and amino acid sequence matching, and estimate static gene dynamic pathways. It also explains applications for system-oriented models to predict the behavior of biological systems. April 2009, 190 pp. ISBN: 978-1-4200-4650-2, £47.99

• Reviews fundamentals of micromachining and fluid flow and control for lab-on-a-chip • Emphasizes analytical applications of microfluidic technology • Includes information that is key to cell, nucleic acid, protein, and genetic analyses, including DNA sequencing • Adapts traditional principles of operations for the size of a chip, optimizing the miniaturization advantage and favorable scaling down • Contains tables that summarize related materials and problem sets that test comprehension of the material • Includes a glossary and extensive references along with a four-page color insert Solutions manual is available with qualifying course adoption

Selected Contents Introduction. Micromachining Methods. Microfluidic Flow. Sample Introduction. Sample Preconcentration. Separation. Detection Methods. Applications to Cellular/Particle Analysis. Applications to Nucleic Acids Analysis. Applications to Protein Analysis. References. Glossary. Technology. Index. February 2010, 418 pp. Soft Cover, ISBN: 978-1-4398-1855-8 £38.99

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Colloids and Interfaces in Life Sciences and Bionanotechnology Second Edition Willem Norde Wageningen University and University Medical Center Groningen, The Netherlands

This classroom-tested reference presents a concise introductory treatment of the physicochemical principles that determine interrelated colloidal and interfacial phenomena and their relevance to various life sciences. The book focuses on concepts that form the basis for understanding this behavior. Whether deciphering the spontaneous assembly of amphiphilic molecules or the intentional fouling of surfaces for the immobilization of cells in bioreactors, this book devotes special attention to reversible and soft colloids, and discusses the colloidal domain in a historical perspective, the size and distribution of particles, and electrokinetic phenomena, and more. June 2011, 495 pp. ISBN: 978-1-4398-1718-6, £39.99

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General Textbooks A First Course in Differential Equations, Modeling, and Simulation

Technical Writing A Practical Guide for Engineers and Scientists

Carlos A. Smith and Scott W. Campbell

Phillip A. Laplante

University of South Florida, Tampa, USA

The Pennsylvania State University, Malvern, USA

Emphasizing a practical approach for engineers and scientists, A First Course in Differential Equations, Modeling, and Simulation avoids overly theoretical explanations and shows readers how differential equations are derived by applying basic physical principles and experimental observations to engineering systems. This textbook also covers classical methods for obtaining the analytical solution of differential equations and Laplace transforms. In addition, the authors discuss how these equations describe mathematical systems and how to use software to solve sets of equations in which analytical solutions cannot be determined. Numerical values are provided in all examples and problems.

Written by a renowned engineer and widely published technical author, this guide enables readers to write, edit, and publish materials of a technical nature, including books, articles, reports, and electronic media. Complementing the traditional writer’s reference manuals and other books on technical writing, it helps readers understand the practical considerations in writing technical content. Drawing on his own work, the author presents many first-hand examples of writing, editing, and publishing technical materials. These examples illustrate how a publication originated as well as various challenges and solutions.

Features

July 2011, 250 pp., Soft Cover ISBN: 978-1-4398-2085-8, £25.99

• Teaches how to model engineering systems • Reviews the necessary physics material • Explores how to obtain the analytical solution of differential equations using actual physical systems • Discusses how the roots of the characteristic equation provide the qualitative nature of the response of any systems • Explains how to use simulation software • Provides numerical values in all examples and problems Solutions manual available with qualifying course adoption

Selected Contents

Random Phenomena Fundamentals of Probability and Statistics for Engineers Babatunde A. Ogunnaike University of Delaware, Newark, USA

Introduction Objects in a Gravitational Field Classical Solutions of Ordinary Linear Differential Equations Laplace Transforms Mechanical Systems: Translational Mechanical Systems: Rotational Mass Balances Thermal Systems Electrical Systems Numerical Simulation Index

“... excellent ... distinguished from the crowded field by the well-explained theory of statistics and how it provides interesting applications.”

May 2011, 345 pp. ISBN: 978-1-4398-5087-9, £57.99

September 2009, 1056 pp. ISBN: 978-1-4200-4497-3, £89.00

—Walid K. Sharabati, The American Statistician, August 2011

“... offers many unique features ... core concepts are written in an easy-to-understand format ... examples and application problems are selected from a wide range ... I highly recommend this book.” —Ali Cinar, Technometrics, August 2011

Solutions manual is available with qualifying course adoption

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