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Contents Bioengineering ......................................................3 Biotechnology ......................................................16
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Bioengineering
NEW!
Biomechanics of the Upper Limbs Mechanics, Modeling and Musculoskeletal Injuries, Second Edition Andris Freivalds Penn State University, University Park, USA
Throughout the past two decades, growth in computer-related jobs has led to considerable increase in the number of work-related musculoskeletal disorders in the upper limbs. Now in its second edition, this comprehensive text is now expanded to include recent findings regarding job stressors and a variety of ergonomic solutions. It provides up-to-date research on the biomechanics of the upper limbs and the mechanics of neuromuscular systems. It covers risk factors for various disorders and tools used to identify their causes. Qualified instructors can access a supporting website offering materials such as PowerPoint slides and sample exams and an instructor's manual with complete solutions.
Features: • Includes chapter-end questions, problems, and references, as numerous figures and tables • Provides numerous examples in each chapter • Features downloadable Power Point slides, sample exams, and other background material on a supporting website • Includes an instructor's manual with complete solutions • Contains end-of-chapter references to enhance further study
Catalog no. 91190, February 2011, c. 564 pp. ISBN: 978-1-4200-9119-9, $119.95
Abridged Contents Introduction to Biomechanics What Is Biomechanics? Basic Concepts Coordinate Systems Force Vector Algebra Static Equilibrium Anthropometry and Center of Mass Determination Friction Dynamics Structure of the Musculoskeletal System Gross Overview of Movements Skeletal System Mechanical Properties of Bone Soft Connective Tissue Joints Neuromuscular Physiology and Motor Control Introduction to Musculature Structure of Muscle Basic Cell Physiology Nervous System Excitation–Contraction Sequence Motor Units Basic Muscle Properties (Mechanics) Energy, Metabolism, and Heat Production Receptors Reflexes and Motor Control Modeling of Muscle Mechanics Laplace Transforms and Transfer Functions Viscoelastic Theory Hill’s Muscle Models Frequency Analysis Frequency Analysis of Passive Muscle Models of the Upper Limbs Musculoskeletal Disorders and Risk Factors Instrumentation Job and Worksite Analysis Hand Tools The Office Environment For Complete Contents, visit www.crctextbooks.com
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Bioengineering
COMING SOON!
BioMEMS Science and Engineering Perspectives Simona Badilescu and Muthukumaran Packirisamy Concordia University, Montreal, Canada
Written to cover often overlooked areas in the field of bioMEMS, this volume spans topics related to biomolecules and complex biological entities as well as topics directly related to the design, fabrication, and characterization of the devices. Unlike other references, this text aids in the fundamental physiochemical understanding of biological processes relevant to the performance of various biosensing devices. Accessible to upper level undergraduate and graduate students enrolled in engineering programs, the book includes problems in each chapter as well as case studies to provide real-life examples.
Features: • Provide a concise overview of bioMEMS principles • Incorporates modern applications • Covers fabrication techniques • Includes examples and problems, as well as review questions and references, in each chapter • Offers case studies to aid with reader application
Abridged Contents: Introduction Introduction to BioMEMS Application Areas Intersection of Science and Engineering Evolution of Systems Based on Size Commercialization, Potential, and Market Substrate Materials Used in BioMEMS Devices Metals Glasses and Ceramics Silicon and Silicon-Based Surfaces Polymers Biopolymers Organic Molecules (Functional Groups) Involved in the Formation of Self-Assembled Monolayers Biomolecules and Complex Biological Entities: Structure and Properties Amino Acids Polypeptides and Proteins Lipids Nucleotides and Nucleic Acids Carbohydrates Enzymes Cells Bacteria and Viruses Engineering of Bioactive Surfaces Plasma Treatment and Plasma-Mediated Surface Modification Surface Modifications Mediated by SelfAssembled Monolayers (SAMs) Langmuir-Blodgett and Layer-by-Layer Assembly Biosmart Hydrogels Methods of Study and Characterization of Surface-Modified Substrates Biosensing Fundamentals Fabrication of BioMEMS Devices Introduction to Microfluidics
Catalog no. K10877, April 2011, c. 364 pp. ISBN: 978-1-4398-1699-8, $99.95
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BioMEMS Life Science Applications
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Bioengineering
NEW!
Introduction to Complexity and Complex Systems Robert B. Northrop University of Connecticut, Storrs, USA
The boundaries between simple and complicated, and complicated and complex system designations are fuzzy and debatable, even using quantitative measures of complexity. However, if you are a biomedical engineer, a biologist, physiologist, economist, politician, stock market speculator, or politician, you have encountered complex systems. Furthermore, your success depends on your ability to successfully interact with and manage a variety of complex systems. In order not to be blindsided by unexpected results, we need a systematic, comprehensive way of analyzing, modeling, and simulating complex systems to predict non-anticipated outcomes. In its engaging first chapters, the book introduces complex systems, Campbell's Law, and the Law of Unintended Consequences, and mathematics necessary for conversations in complex systems. Subsequent chapters illustrate concepts via commonly studied biological mechanisms. The final chapters focus on higher-level complexity problems, and introduce complexity in economic systems. Designed as a reference for biologists and biological engineers, Introduction to Complexity and Complex Systems lends itself to use in a classroom course to introduce advanced students studying biomedical engineering, biophysics, or physiology to complex systems. Engaging and illustrative, this book aids scientists and decision makers in managing biological complexity and complex systems.
Catalog no. K11775, January 2011, 551 pp. ISBN: 978-1-4398-3901-0, $79.95
Features: • Describes the characteristics of certain complex living systems • Provides dynamic models for various complex systems • Offers present-day examples for dealing with complex systems • Includes homework problems for better comprehension
Abridged Contents: Introduction to Complexity and Complex Systems Introduction to Complexity Why Study Complex Systems? Human Responses to Complexity Complex Systems Engineering Chapter Summary Introduction to Large Linear Systems Introduction to Nonlinear Biochemical Systems and Biochemical Oscillators Modularity, Redundancy, Degeneracy, Pleiotropy and Robustness in Complex Biological Systems The Evolution of Biological Complexity; Invertebrate Immune Systems The Complex Adaptive and Innate Human Immune Systems Complexity in Quasispecies MicroRNAs Introduction to Physiological Complexity Examples of Models of Some Complex Physiological Systems The Quest for Quantitative Measures of Complexity "Irreducible and Specified Complexity" in Living Systems Introduction to Complexity in Economic Systems Dealing with Complexity Appendix Bibliography and References Glossary Index
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Bioengineering
NEW! Includes CD-ROM
Applied Medical Image Processing A Basic Course Wolfgang Birkfellner Department of Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria
Based on the authors’ decades-long tenure in clinical environments and their extensive teaching experience, Applied Medical Image Processing: A Basic Course introduces the basic methods in applied image processing without assuming that readers have extensive prior knowledge beyond basic applied mathematics, physics, and programming. Illustrated with simple, well-commented MATLAB® examples, the book’s tangible and accessible presentation demonstrates real-life applications. The rapid evolution of radiological imaging in the past four decades has brought medical image processing into the forefront as an essential tool for clinical research, a crucial component of modern diagnostics, and an indispensable element the actual treatment of diseases. A hands-on introduction to the basic image processing algorithms used in clinical routine applications, this book closes the gap between basic engineering knowledge such as simple programming and applied mathematics on the one hand, and the general understanding of a science that affects the health of a broad public.
Features: • Provides a self-contained, complete basic introduction to the field, emphasizing special requirements for processing medical imaging data • Includes many practical examples for MATLAB and Octave with a CD-ROM featuring image material and program files • Covers three-dimensional volume data sets commonly encountered in tomographic imaging • Addresses the most frequently used visualization techniques in medical imaging, including image segmentation, 3D image fusion, and tomographic reconstruction • Requires little more than basic algebra and basic programming skills Catalog no. K11176, January 2011, 403 pp. ISBN: 978-1-4398-2444-3, $69.95
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Abridged Contents: A Few Basics of Medical Image Sources, J. Hummel Radiology The Electromagnetic Spectrum Basic X-ray Physics Attenuation and Imaging Computed Tomography Magnetic Resonance Tomography Ultrasound Nuclear Medicine and Molecular Imaging Other Imaging Techniques Radiation Protection and Dosimetry Summary and Further References Image Representation, W. Birkfellner Pixels and Voxels Gray Scale and Color Representation Image File Formats DICOM Other Formats – Analyze 7.5, NifTI and Interfile Image Quality and the Signal-to-Noise Ratio Practical Lessons Summary and Further References Operations in Intensity Space, W. Birkfellner The Intensity Transform Function and the Dynamic Range Windowing Histograms and Histogram Operations Dithering and Depth Practical Lessons Summary and Further References Filtering and Transformations, W. Birkfellner The Filtering Operation The Fourier Transform Other Transforms Summary and Further References Segmentation, W. Birkfellner Spatial Transforms, W. Birkfellner Registration, W. Birkfellner Rendering and Surface Models, W. Birkfellner CT Reconstruction, M. Figl A Selection of MATLAB Commands For complete contents, visit www.crctextbooks.com
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Bioengineering
NEW!
Biology for Engineers Arthur T. Johnson University of Maryland, College Park, USA
Introducing the field of biology to today’s engineering students, this entry-level text minimizes unnecessary memorization of connections and classifications and emphasizes concepts, technology, and the utilization of living things. Filled with practical examples, the book discusses biological responses from the perspectives of psychology, human factors, genetics, plant and animal physiology, imaging, control systems, actuary, and medicine. Offering numerous tables of useful information, it covers the scaling of biological responses and attributes as well as different types of applications related to biological systems.
Features: • Explores areas in physics, chemistry, mathematics, and engineering relating to biology • Introduces concepts and terminology needed to understand more advanced biology literature • Examines the differences between biological engineering and biological science • Includes a chapter on scaling relations showing how size effects other physical characteristics • Surveys a broad range of application areas A solutions manual is available with qualifying course adoption
Abridged Contents: I. INTRODUCTION Science and Engineering Scientific Method Mathematical Modeling Biological Engineering Expectations for Biological Engineers About Predictions About This Book Questions II. PRINCIPLES FROM THE SCIENCES Principles of Physics Effort and Flow Variables Balances States of Matter Equivalence of Work and Energy Free Energy Disorder and Entropy Heat Transfer Movement of Materials Fluid Mechanics Solid Mechanics Electricity Temperature Effects Questions Principles of Chemistry Periodic Nature of Elements Chemical Bonding Chemical Equilibrium Acids and Bases Reaction Rates Carbon Chemistry Physical Chemistry in Water Principles of Mathematics and Engineering Sciences Principles of Biology III. RESPONSES OF LIVING SYSTEMS Biological Responses in Context IV. SCALING FACTORS
Catalog no. 77635, January 2011, 775 pp. ISBN: 978-1-4200-7763-6, $99.95
V. UTILIZING LIVING SYSTEMS Biological Engineering Solutions APPENDICES REFERENCES
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Bioengineering
Biomedical Microsystems Ellis Meng University of Southern California, Los Angeles, USA
Written by an active researcher recently named one of Technology Review’s “Young Innovators Under 35”, this book introduces materials, fabrication technology, and the necessary components of all bioMEMS. Starting with an introduction to the benefits of miniaturization, the author covers fundamental principles and building blocks, including microfluidic concepts, lab-on-achip systems, and sensing and detection methods. The final chapters explore several important applications of bioMEMS, such as microdialysis, catheter-based sensors, MEMS implants, neural probes, and tissue engineering. Detailed examples, exercises, and illustrations help elucidate the concepts.
Features: • Presents a rigorous, in-depth treatment of bioMEMS materials, methods, processes, and concepts • Emphasizes practical knowledge useful for application to real-world problems • Describes research and commercialized bioMEMS devices as well as emerging applications • Includes detailed examples, laboratory exercises, and a variety of homework problems • Contains numerous illustrations of concepts, processes, and devices • Offers downloadable original images for qualifying instructors at www.crcpress.com Solutions manual available for qualifying instructors
Catalog no. 51229, January 2011, 408 pp. ISBN: 978-1-4200-5122-3, $89.95
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Abridged Contents: Introduction Evolution of MEMS Applications of MEMS BioMEMS Applications MEMS Resources Text Goals and Organization Miniaturization and Scaling BioMEMS Materials Traditional MEMS and Microelectronic Materials Polymeric Materials for MEMS Biomaterials Microfabrication Methods and Processes for BioMEMS Introduction Microlithography Doping Micromachining Wafer Bonding, Assembly, and Packaging Surface Treatment Conversion Factors for Energy and Intensity Units Laboratory Exercises Microfluidics Introduction and Fluid Properties Concepts in Microfluidics Fluid-Transport Phenomena and Pumping Flow Control Laboratory Exercises Lab-on-a-Chip or Micro Total Analysis Systems Microanalytical Systems in Chemistry and Biology Sample Pretreatment Sample Introduction Separations Sensing and Detection Methods Applications to Cells, Nucleic Acids, and Proteins Clinical Monitoring MEMS Implants and Bioelectric Interfaces Problems and references appear at the end of each chapter.
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Bioengineering
Biomaterials A Nano Approach Seeram Ramakrishna, Murugan Ramalingam, T.S. Sampath Kumar, and Winston O. Soboyejo There are several well-known books on the market that cover biomaterials in a general way, but none provide adequate focus on the future of and potential for actual uses of emerging nanontechnology in this burgeoning field. Biomaterials: A Nano Approach is written from a multi-disciplinary point of view that integrates aspects of materials science and engineering, nanotechnology, bioengineering, and biosciences. The book fills a glaring void in the literature by providing a comprehensive discussion of biomaterials and a scientifically plausible extrapolation of likely scenarios in which nanotechnology could play a significant role. The authors introduce and examine basic concepts, processing methodologies, and techniques involved in the preparation and characterization of nanobiomaterials that are specific to biomedical applications. A Self-Contained Book Illustrating Past, Present, and Future Trends in Biomaterials Spanning from the historical development of biomaterials to cutting-edge advances in the field, the text describes how basic concepts in nanotechnology are applied to the processing of novel nanobiomaterials, including nanostructured metals and alloys. With its illustrative examples and presentation of applications, this text offers a solid framework for understanding present and future trends of biomaterials in human healthcare systems. It is an ideal companion resource for students, researchers, and industrial scientists who specialize in biomaterials and nanobiomaterials.
Features: • Focuses on the application of nanobiomaterials as a key component in next-generation biomaterials • Covers a range of nanobiomaterials and their potential applications • Discusses materials used for biomedical applications, including tissue engineering and drug delivery • Describes the biological and environmental effects of nanomaterials • Presents case studies that demonstrate the vital role of nanobiomaterials • Includes exercises, illustrative examples, and useful tables with current data
Contents: Overview of Biomaterials Basics of Human Biology Degradation and Corrosion of Biomaterials Failure and Tribology of Biomaterials Nanoscale Phenomena Metallic Biomaterials Ceramic Biomaterials Polymeric Biomaterials Composite Biomaterials Nanobiomaterials for Tissue Engineering Glossary Exercises References
Catalog no. 47817, 2010, 372 pp. ISBN: 978-1-4200-4781-3, $99.95
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Bioengineering
Signals and Systems Analysis in Biomedical Engineering Second Edition Robert B. Northrop University of Connecticut, Storrs, USA
The interdisciplinary field of biomedical engineering requires its practitioners to master not only engineering skills but also a diversity of biological science material. This text helps biomedical engineering students and professionals strengthen their skills in the network of applied mathematics that ties together these diverse disciplines. Based on the author's 30 years of experience in teaching as well as his personal research on neurosensory systems, this book, now in its second edition, provides a ready source of information on the specialized mathematical techniques most useful in describing and analyzing biomedical signals.
Features: • Focuses on the mathematical tools required to analyze and describe the signals and systems found in biomedical engineering • Includes a comprehensive chapter on joint time-frequency analysis of nonstationary biomedical signals, and the use of wavelets in JTFA • Explores the mathematics of tomographic imaging • Describes the analytical signal and the Hilbert transform • Discusses the analysis of nonlinear systems, nonlinear oscillators, and biological clocks • Introduces the analysis of and modeling strategies for complex systems • A solutions manual is available with qualifying course adoption
Catalog no. K10633, 2010, 654 pp. ISBN: 978-1-4398-1251-8, $99.95
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Abridged Contents: Introduction to Biomedical Signals and Systems General Characteristics of Biomedical Signals General Properties of PSs Review of Linear Systems Theory Linearity, Causality, and Stationarity Analog Systems Systems Described by Sets of ODEs Linear System Characterization Discrete Signals and Systems Stability of Systems The Laplace Transform and Its Applications Introduction Properties of the Laplace Transform Some Examples of Finding Laplace Transforms The Inverse Laplace Transform Applications of the Laplace Transform Fourier Series Analysis of Periodic Signals Introduction Properties of the FS FS Examples The Continuous Fourier Transform Introduction Properties of the CFT ADC and the Sampling Theorem The Discrete Fourier Transform Introduction to Joint TimeFrequency Analysis of Biomedical Signals Introduction to the Analysis of Stationary Noise, and Signals Contaminated with Noise Basic Mathematical Tools Used in the Characterization of Physiological Systems Introduction to the Mathematics of Tomographic Imaging Introduction to the Analysis of Nonlinear Biochemical Systems and Biochemical Oscillators Introduction to Complex Systems in Biology and Medicine Glossary Appendices
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Bioengineering
COMING SOON! Includes CD-ROM
Quantitative Understanding of Biosystems An Introduction to Biophysics Thomas M. Nordlund University of Alabama at Birmingham, USA
“Combines a nice balance of topics with important basic material … . The emphasis on problems, projects, and tools is very helpful.” —Stephen J. Hagen, University of Florida, Gainesville, USA
This color text clearly describes the biological physics of macromolecules, subcellular structures, and whole cells, including interactions with light. It provides a hands-on understanding of the movement of microorganisms, reviews the necessary mathematics, discusses quantum mechanics in biosystems, and describes the transition from discreet random walks to continuum diffusive motion. The text also contains standard exercises, advanced problems, and mini-projects. An accompanying CD-ROM includes “active” versions of Excel graphs and diagrams from the text, along with links to mathematical and biological/biochemical source data.
Features: • Provides a hands-on understanding of the movement of microorganisms, enabling students to analyze positions, velocities, and forces of real microorganisms • Reviews the necessary mathematics, including geometry, calculus, and differential equations • Discusses quantum mechanics in biosystems, covering photosynthesis and micro and chemical reactions • Describes the transition from discreet random walks to continuum diffusive motion • Contains standard exercises, advanced problems, and mini-projects • Includes a CD-ROM with "active" versions of Excel graphs and diagrams from the text, along with links to mathematical and biological/biochemical source data Solutions manual available for qualifying instructors
Catalog no. 89772, February 2011, c. 583 pp. ISBN: 978-1-4200-8972-1, $89.95
Abridged Contents: INTRODUCTION, APPROACH, AND TOOLS Introduction to a New World Biological and Nonliving Worlds Contrasted Hierarchical Structure and Function Some Important Quantities to Get Started Biophysics and Biochemistry Operate in Water (Water 1) How (Most) Physicists Approach Biophysics Math Tools: First Pass STRUCTURE AND FUNCTION Water Structures: From 0.1 to 10 nm and Larger First Pass at Supramolecular Structures: Assemblies of Biomolecules Putting a Cell Together: Physical Sketch BIOLOGICAL ACTIVITY: QUANTUM MICROWORLD Quantum Primer Light and Life Photosynthesis Direct Ultraviolet Effects on Biological Systems BIOLOGICAL ACTIVITY: (CLASSICAL) MICROWORLD Mechanics and Dynamics Random Walks, Diffusion, and Polymer Conformation Statistical Physics and Thermodynamics Primer Reactions: Physical View Molecular Machines: Introduction Assembly Appendix A: Reading Skills and Information Sources Appendix B: Snapshot of the Supporting CD Glossary Further Resources Index Problem solving and references appear at the end of each chapter.
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Bioengineering
A Laboratory Course in Biomaterials Wujing Xian University of Illinois at Urbana-Champaign, USA
A new teaching tool for instructors in biomaterials and bioengineering, this volume is a comprehensive laboratory textbook. It trains students in laboratory skills, data analysis, problem solving, and scientific writing and integrates a variety of principles that include materials science, chemistry, biochemistry, molecular and cell biology, and engineering. Providing detailed descriptions, explanations, and illustrations of experiments, the text also includes a series of questions and answers at the end of each chapter to clarify concepts. Many of the experiments presented are adapted from research papers to reflect the recent progress in biomaterials and bioengineering.
Features: • Presents detailed, step-by-step descriptions of lab procedures and explanations for the underlying principles • Contains user-friendly graphic illustrations for the experiments • Provides a series of questions and answers at the end of each chapter to clarify concepts and induce critical thinking • Includes text boxes with in-depth information, case studies, and lab tips • Offers information on equipment, reagents, and supplies for instructors
Catalog no. 75829, 2009, 216 pp., Soft Cover ISBN: 978-1-4200-7582-3, $61.95
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Abridged Contents: Basic Laboratory Skills Commonly Used Lab Equipment and Supplies Waste Disposal Liquid Transfer Weighing Making Solutions Error Analysis Module I. Drug Delivery: Controlled Release of Encapsulated Protein from PLGA Encapsulation of BSA in PLGA Microspheres Evaluation of the Encapsulation Efficiency and the Drug Load Controlled Release of BSA from PLGA Microspheres Evaluation of Controlled Release Profile Questions Appendix: Recipes and Sources for Equipment, Reagents, and Supplies Module II. Natural Biomaterials: Collagen and Chitosan Extracting Acid-Soluble Type I Collagen from Bovine Calf Skin Purification of Extracted Collagen Analysis of Collagen Extraction and Purification by Electrophoresis Fabricating Collagen/Chitosan Sponges Questions Appendix: Recipes and Sources for Equipment, Reagents and Supplies Basic Laboratory Skills II. Cell Culture and Microscopy Cell Culture Exercises Module III. Biocompatibility Testing: Cytotoxicity and Adhesion Module IV. Tissue Engineering: Organotypic Cultures of Skin Equivalents Module V. Bioceramics: Porous Hydroxyapatite Composite Appendix: Answers
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Bioengineering
Engineering Genetic Circuits Chris J. Myers University of Utah, Salt Lake City, USA
An Introduction to Systems Bioengineering Takes a Clear and Systematic Engineering Approach to Systems Biology Focusing on genetic regulatory networks, Engineering Genetic Circuits presents the modeling, analysis, and design methods for systems biology. It discusses how to examine experimental data to learn about mathematical models, develop efficient abstraction and simulation methods to analyze these models, and use analytical methods to guide the design of new circuits. After reviewing the basic molecular biology and biochemistry principles needed to understand genetic circuits, the book describes modern experimental techniques and methods for discovering genetic circuit models from the data generated by experiments. The next four chapters present stateof-the-art methods for analyzing these genetic circuit models. The final chapter explores how researchers are beginning to use analytical methods to design synthetic genetic circuits. This text clearly shows how the success of systems biology depends on collaborations between engineers and biologists. From biomolecular observations to mathematical models to circuit design, it provides essential information on genetic circuits and engineering techniques that can be used to study biological systems.
Features: • Introduces relevant biology and biochemistry for readers with an engineering background • Covers key methods for modeling and analyzing genetic circuits, such as differential equations and stochastic analysis • Describes abstraction methods, which can substantially improve the efficiency of analyses • Uses the lysis/lysogeny decision circuit of phage lambda as an example throughout to help illustrate the various methods • Presents an introduction to the emerging area of synthetic biology • Includes exercises and self-study problem sets in every chapter • Offers iBioSim software, lecture slides, and a password-protected solutions manual on the author’s website Catalog no. C3244, 2010, 306 pp. ISBN: 978-1-4200-8324-8, $71.95
Contents: An Engineer’s Guide to Genetic Circuits Chemical Reactions Macromolecules Genomes Cells and Their Structure Genetic Circuits Viruses Phage lambda: A Simple Genetic Circuit Learning Models Experimental Methods Experimental Data Cluster Analysis Learning Bayesian Networks Learning Causal Networks Experimental Design Differential Equation Analysis A Classical Chemical Kinetic Model Differential Equation Simulation Qualitative ODE Analysis Spatial Methods Stochastic Analysis A Stochastic Chemical Kinetic Model The Chemical Master Equation Gillespie’s Stochastic Simulation Algorithm Gibson/Bruck’s Next Reaction Method Tau-Leaping Relationship to Reaction Rate Equations Stochastic Petri-Nets Phage lambda Decision Circuit Example Spatial Gillespie Reaction-Based Abstraction Irrelevant Node Elimination Enzymatic Approximations Operator Site Reduction Statistical Thermodynamical Model Logical Abstraction Genetic Circuit Design Solutions to Selected Problems References Glossary Sources and problems appear at the end of each chapter.
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Bioengineering
Introduction to Physics in Modern Medicine Second Edition Suzanne Amador Kane Haverford College, Pennsylvania, USA
Fully updated, this volume builds on the bestselling original to provide medical and physics students with an exploration of the physics-related applications found in state-of-the-art medical centers. Requiring very little physics, biology, or chemistry and keeping mathematics to a minimum, the application-dedicated chapters adhere to simple and self-contained qualitative explanations that make use of examples and illustrations. With an enhanced emphasis on digital imaging and computers in medicine, the text gives readers a fundamental understanding of the practical application of each. Supporting material includes an author-maintained website, and a solutions manual for qualifying instructors.
Features: • Introduces state-of-the-art medical physics • Explores recent developments and emerging technologies • Contains case studies, worked examples, and exercises • Offers supporting material online including an author maintained website • A solutions manual is available upon qualified course adoption
Catalog no. C9438, 2009, 448 pp., Soft Cover ISBN: 978-1-58488-943-4, $59.95
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Abridged Contents: Introduction and Overview Telescopes for Inner Space Optics: the science of light Fiber optics applications in medicine: endoscopes and laparoscopes Robotic surgery and virtual reality in the operating room Telemedicine and military applications Lasers in Medicine What is a laser? More on the science of light: beyond the rainbow How lasers work How light interacts with body tissues Laser beams and spatial coherence Cooking with light: photocoagulation Trade-offs in photocoagulation: power density and heat flow Cutting with light: photovaporization More power: pulsed lasers Lasers and color The atomic origins of absorption How selective absorption is used in laser surgery Lasers in dermatology Laser surgery on the eye New directions: lasers in dentistry Advantages and drawbacks of lasers for medicine New directions: photodynamic therapy—killing tumors with light New directions: Diffusive optical imaging Seeing with Sound Sound waves What is ultrasound? X-Ray Vision Images from Radioactivity Radiation Therapy and Radiation Safety in Medicine Magnetic Resonance Imaging Brain mapping and functional MRI Each chapter contains an introduction, questions, and problems.
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Bioengineering
Introduction to Molecular Biology, Genomics and Proteomics for Biomedical Engineers Robert B. Northrop and Anne N. Connor University of Connecticut, Storrs, USA
Illustrates the Complex Biochemical Relationships that Permit Life to Exist It can be argued that the dawn of the 21st century has emerged as the age focused on molecular biology, which includes all the regulatory mechanisms that make cellular biochemical reaction pathways stable and life possible. For biomedical engineers, this concept is essential to their chosen profession. Introduction to Molecular Biology, Genomics, and Proteomics for Biomedical Engineers hones in on the specialized organic molecules in living organisms and how they interact and react. The book is an exceptional resource for further exploration into the biochemistry, molecular biology, and genomics fields. It is also beneficial for electrical, chemical, and civil engineers as well as biophysicists with an interest in modeling living systems. This seminal reference includes many helpful tools for self study, including— • 143 illustrations, 32 in color, to bolster understanding of complex biochemical relations • 20 tables for quick access to precise data • 100 key equations • Challenging self-study problems within each chapter Conveys Human Progress in the Manipulation of Genomes at the Molecular Level In response to growing global interest in biotechnology, this valuable text sheds light on the evolutionary theories and future trends in genetic medicine and stem cell research. It provides a broader knowledge base on life-permitting complexities, illustrates how to model them quantitatively, and demonstrates how to manipulate them in genomic-based medicine and genetic engineering.
Features: • Defines complex terminology in a large, comprehensive glossary • Addresses ethical issues in stem cell research, cloning, and the creation of geneticallymodified plants and animals • Contains a sizeable bibliography for further independent study of discussed topics • Describes the role of stem cells in regenerative medicine and in cancer treatment • Comprises robust chapters on nucleic acids and proteins – the building blocks of molecular biology
Contents: Introduction Life and Death Review of Basic Cell Anatomy and Physiology Introduction to Physical Biochemistry and Biochemical Systems Modeling The Basis of Genetic Inheritance Nucleic Acids and Their Functions A Review of Proteins The Genetic Basis for Certain Inheritable Diseases: Genomic Medicine Some Instrumental Methods Used in Genomics, Proteomics, and Forensic Science Applications of Genomics Ethical Issues in Genetic Engineering Appendix Bibliography and References Glossary
A solutions manual is available for instructors who convert this reference for classroom use.
Catalog no. 61194, 2009, 480 pp. ISBN: 978-1-4200-6119-2, $102.95
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Biotechnology
COMING SOON!
Biotechnology Operations Principles and Practices Michael J. Roy University of Wisconsin-Madison, USA
Based on the author's extensive teaching experience, this book introduces key biotechnology developments and covers critical elements of biotechnology operations. Comprehensive and practical, but with a focus on fundamentals, it emphasizes the themes of planning and integrating the seven key operational endeavors: scientific and management skills of biomanufacturing, clinical trials, nonclinical studies, project management, quality assurance, quality control, and regulatory affairs. The author discusses these subjects in relation to development planning, process and pathways, management of integrated projects and the business and economic aspects of development. Describing the functional areas that must be successfully integrated to bring a biotechnology product to market, this book presents a roadmap and reference for biotechnology operations, integrating the functional areas through the processes of product planning and design and the practice of project management. It also applies lessons gleaned during past decades as novel products have been developed from emerging scientific discoveries. The lessons highlight development principles and practices that could reduce risk, resolve problems, and help the industry to bring safe and effective biotechnology products of the future to market more efficiently and quickly.
Features: • Provides an introduction to each key biotechnology developments subject in one volume • Incorporates an integrated approach, tying together the various functional areas • Emphasizes the need to both plan and integrate a program and provides the information with which to successfully lead such efforts • Uses relatively simple language, explains jargon, and uses diagrams to describe processes so subjects are easily understood Catalog no. K11486, March 2011, c. 416 pp. ISBN: 978-1-4398-3027-7, $99.95
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Abridged Contents: Introduction to Biotechnology Operations: Planning for Success Biotechnology Operations Marketing, Financial and Business Considerations for Development Product Development Planning Summary of Planning for Success Project Management Project Management in Biotechnology Background of Project Management Project Management in Biotechnology Project Management in Biotechnology Operations Project Management with Contracts and Collaborations Tools for Effective Project Management Summary of Project Management in Biotechnology Development Regulatory Affairs The U.S. Food and Drug Administration: Law and Regulations for Biopharmaceuticals FDA-Regulated Products U.S. FDA Regulatory Information and Resources: Regulatory Intelligence Regulatory Operations for FDA Applications Summary on Regulatory Affairs Activities in Biotechnology Operations Regulatory Compliance Regulatory Compliance Quality Systems to Meet Regulatory Compliance Compliance for Biopharmaceuticals: Other Regulations of Importance Inspection and Enforcement Compliance with Non-FDA Regulations: International, National, State and Local Quality Systems Biomanufacture Quality Control Nonclinical Studies Clinical Trials Glossary Additional Reading Practical Problems and Questions
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Biotechnology
Healthcare Biotechnology A Practical Guide Dimitris Dogramatzis Dogramatzis Pharmacy, Athens, Greece
It is a mammoth task to bring a biotechnology innovation from inception to widespread therapeutic use. It takes strong managerial skills and a solid grounding in biopharmaceutical research and development procedures to foresee and plan for all of the possibilities and pitfalls involved. Focusing on the management of healthcare-related biotech—from product conception through regulatory approval and the rest of its life cycle— Healthcare Biotechnology: A Practical Guide provides a practical, all-encompassing resource to assist professionals step by step in their everyday activities, from the lab to the boardroom. Divided into easily digestible sections, the book covers current systems, recent progress and controversy, major players and products, and comparisons with the pharmaceutical industry. It covers topics including: • intellectual property protection and management • the innovation cycle • patent application • commercialization and competition • funding • partnering • cash-intensive activities • financing alternatives • complexities of alliance implementation and management Highlighting research, development, and biomanufacturing, it examines clinical trial design and regulations, "fast-track" approvals, and patient recruitment, as well as production platforms and processes, costs, strategies, and timelines. The author investigates marketing, including planning, promotion, pricing, supply chain management, and bio-brand lifecycle management. He concludes with tips on running the business, offering diverse biobusiness models and Catalog no. K12108, January 2011, 689 pp. ISBN: 978-1-4398-4746-6, $99.95
reasonable expectations, from inception through maturity and decline.
FEATURES: • Provides end-of-chapter problems and appropriate essays for each subject covered • Offers a practical step-by-step guide for both graduate students and industry professionals • Includes a list of abbreviations and a business plan outline • Presents challenging chapter-end questions and exercises to inspire critical thinking • Contains hundreds of illustrations, tables, figures, references, as well as helpful appendices A solutions manual and more than 1000 PowerPoint slides are available with qualifying course adoption
Contents: THE HEALTHCARE BIOTECHNOLOGY INDUSTRY Bioeconomy INTELLECTUAL PROPERTY Intellectual Property Management Biolicensing FUNDING Biofinance Biopartnering NEW PRODUCT DEVELOPMENT Biodrug Research Biomanufacturing MARKETING Biomarketing Planning Biopromotion Biopricing Biosupply Chain Biobrand Life Cycle Management RUNNING THE BUSINESS Biobusiness Models Biocompany Life Cycle APPENDICES
For more information and complete contents, visit www.crctextbooks.com
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Biotechnology
NEW!
Environmental Microbiology for Engineers Volodymyr Ivanov Nanyang Technological University, Singapore
This book helps students and new engineers understand how microbiology can be used in environmental research and practical applications. Written for senior undergraduate to graduate level civil and environmental engineering students, this textbook encompasses both fundamental and applied principles and covers topics such as the microbiology of water, wastewater, soil, and air biotreatment systems used in environmental engineering. It also covers civil engineering topics such as biocementation, biocorrosion, biofouling and biodeterioration of materials. Suitable for environmental engineers with little to no biology training, this book provides a thoroughly up-to-date introduction to current trends in environmental microbiology and engineering. Microbial classification is represented as a periodic table with theoretical connections between all prokaryotic groups and highlighting their environmental applications. The textbook includes quizzes for each chapter, tutorials and exam questions. A separate solutions manual is available with qualifying course adoption. Combining microbiological knowledge and environmental biotechnology principles in a readable fashion, the book includes topics such as: • Structures and functions of microbial cell and cell aggregates • Applied microbial genetics and molecular biology • Diversity and function of microorganisms in environmental engineering systems • Environmental bioengineering processes • Microbiological monitoring of environmental engineering systems • Microbiology of water and wastewater treatment • Biocementation and bioc1ogging of soil • Biocorrosion of constructions • Biodeterioration of materials • Biopollution of indoor environment Catalog no. 92340, January 2011, 438 pp. ISBN: 978-1-4200-9234-9, $99.95
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Features: • Combines microbiological knowledge and environmental biotechnology principles in a readable fashion for environmental and civil engineers • Contains a glossary of terms • Supplies a quiz and tutorial questions at the end of each chapter • Discusses ‘hot’ topics in the area such as, environmental bionanotechnology, microbial geotechnology, and environmental engineering of closed microbial ecosystems • Teaches with minimal use of mathematical equations • Solutions manual available with qualifying course adoption
Abridged Contents: Stages of Bioprocessing Bioagents of Bioprocessing Microbial Metabolism and its control Molecular Biology and Genetics of Microorganisms Selection of Pure Cultures Classifications and Identifications of Prokaryotes Periodic Table of Physiological Groups of Prokaryotes Nutrition and Growth Cultivation of Microorganisms and Downstream Processes Microbial Adaptations and Engineering Control Microbial Natural Ecosystems Microbial Engineering Ecosystems Public Health Microbiology for Engineers Microbiology of Water Treatment Microbiology of Aquatic Ecosystems Microbiology of Anaerobic Wastewater Treatment Microbiology of Aerobic Wastewater Treatment Microbiology of Solid Wastes Biotreatment Microbiology of Soil Bioremediation Microbiology of Exhaust Gases Biotreatment Biocorrosion, Biodeterioration and Biofouling
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Biotechnology
Fundamentals of Microfluidics and Lab on a Chip for Biological Analysis and Discovery Paul C.H. Li Simon Fraser University, Burnaby, British Columbia, Canada
Authored by one of the field’s pioneering researchers, this volume focuses on all key aspects of the microfluidic lab-on-a-chip technologies to offer an exceptionally cohesive overview of the science, its limitations, breakthroughs made over the years, and currently emerging advances. The book emphasizes analytical applications of microfluidic technology and presents in-depth coverage of micromachining methods, microfluidic operations, chemical separations, sample preparation and injection methods, detection technology, and various chemical and biological analyses. Other topics of interest include the use of polymeric chips, fluid flow valve and control, single-cell analysis, DNA and RNA amplification techniques, DNA hybridization, immunoassays, and enzymatic assays.
Features: • Reviews fundamentals of micromachining and fluid flow and control for lab-on-a-chip • Emphasizes analytical applications of microfluidic technology • Includes information that is key to cell, nucleic acid, protein, and genetic analyses, including DNA sequencing • Adapts traditional principles of operations for the size of a chip, optimizing the miniaturization advantage and favorable scaling down • Contains tables that summarize related materials and problem sets that test comprehension of the material • Includes a glossary and extensive references along with a four-page color insert • Solutions manual available with qualifying course adoption
Catalog no. K10977, 2010, 418 pp., Soft Cover ISBN: 978-1-4398-1855-8, $99.95
Abridged Contents: Introduction Micromachining Methods Micromachining of Silicon Micromachining of Glass Micromachining of Fused Quartz (or Fused Silica) Micromachining of Polymeric Chips Metal Patterning World-to-Chip Interface Problem Sets Microfluidic Flow Liquid Pumping Methods Microfluidic Flow Control Problem Sets Sample Introduction Electrokinetic Injection Hydrodynamic Injection Other Sample Injection Methods Problem Sets Sample Preconcentration Sample Stacking Extraction Porous Membrane Other Preconcentration Methods Problem Sets Separation Gas Chromatography (GC) Capillary Electrophoresis (CE) Chromatographic Separations Coupled Separations Problem Sets Detection Methods Optical Detection Methods Electrochemical (EC) Detection Mass Spectrometry (MS) Other Detection Methods Problem Sets Applications to Cellular/Particle Analysis Retention of Cells and Particles Studies of Cells in a Flow Other Cell Operations Problem Sets Applications to Nucleic Acids Analysis Applications to Protein Analysis
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Biotechnology
Transport Phenomena Fundamentals Second Edition Joel Plawsky Rensselaer Polytechnic Institute, Troy, New York, USA
One of the foundations of chemical engineering is built upon transport phenomena. This text provides a unified treatment of heat, mass, and momentum transport based on a balance equation approach. The first part of the book takes students through the balance equation in the context of diffusive transport. The second half builds upon the balance equation description of diffusive transport by introducing convective transport terms, focusing on partial rather than ordinary differential equations. A series of example modules are provided online on the author’s website, which is designed to be a living component of the course.
Features: • Presents a unified, holistic approach to transport processes • Uses finite element methods as a tool for enhanced understanding • Teaches students to analyze computer-based solutions to check for validity • Incorporates momentum, heat, mass, and charge transport • Explains the mathematics behind the description of the phenomena and the development of the equations • Solutions manual available with qualifying course adoption
Catalog no. 62336, 2010, 857 pp. ISBN: 978-1-4200-6233-5, $129.95
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Abridged Contents: Introductory Concepts Scope of Transport Phenomena Preliminary Assumptions Equilibrium Foundations Defining Equilibrium Fluid Statics Buoyancy and Stability Fluids in Rigid Body Motion Fluxes, Gradients, and Transport Properties Momentum Transport – Newton's Law of Viscosity Energy Transport – Fourier's Law of Heat Conduction Mass Transport – Fick's Law of Diffusion Charge Transport – Ohm's Law of Conduction Driving Force – Resistance Concepts Flux Laws in Two and Three Dimensions Transport Properties of Materials One-Dimensional, Steady-State Diffusive Transport Generation Accumulation Transport Enhancement Using Extended Surfaces Multidimensional Effects, Potential Functions, and Fields Convective Transport: Microscopic Balances Macroscopic or Engineering Balances Convective Transport on a Flat Plate (Laminar Boundary Layers) Convective Transport: Systems with Curvature Turbulent Boundary Layers Radiative Transport Appendix A: Vector Mathematics Appendix B: Mathematical Functions and Heisler Charts Appendix C: Exact Solution to the Boundary Layer Equations Appendix D: Thermal and Transport Properties of Materials
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Biotechnology
Systems Biology and Bioinformatics A Computational Approach Kayvan Najarian, Siamak Najarian, Shahriar Gharibzadeh, and Christopher N. Eichelberger Emphasizing computational methods, Systems Biology and Bioinformatics provides an introduction to system biology and its impact on biology and medicine. It reviews basic principles of molecular and cell biology using a system-oriented approach, with a brief description of the highthroughput biological experiments that produce databases. The methods presented include techniques to discover genes, perform nucleotide and amino acid sequence matching, and estimate static gene dynamic pathways. It also explains applications for system-oriented models to predict the behavior of biological systems.
Features: • Provides methods to integrate high level imaging data and molecular level measurements to model biological systems • Presents necessary biological and mathematical background • Includes practical examples and experiments with real data as well as a complete solutions manual • Covers the computational approach and advanced mathematical methods
Catalog no. 46500, 2009, 190 pp. ISBN: 978-1-4200-4650-2, $71.95
Abridged Contents: Cell Biology An Introduction to Cell Structure Proteins as Tools of the Cell Genes: Directors of the Cell Cell Cycle Bioassays Southern Blotting Fluorescent In Situ Hybridization Sanger (Dideoxy) Method Polymerase Chain Reaction Analyzing Protein Structure and Function Studying Gene Expression and Function—DNA Microarrays Review of Some Computational Methods Introduction to Probability and Stochastic Processes Theories Bayesian Theory Test of Hypothesis Expectation Maximization Method Maximum Likelihood Theory System Identification Theory Computational Structural Biology: Protein Structure Prediction Protein Structure Prediction Methods Data Resources Computational Structural Biology: Protein Sequence Analysis Pairwise Sequence Matching Multiple Sequence Alignment Genomics and Proteomics Methods for Identification of Differentially Expressed Genes or Proteins Binary and Bayesian Networks as Static Models of Regulatory Pathways Metabolic Control Theory for Static Modeling of Metabolic Pathways System Identification and Control Theory for Dynamic Modeling of Biological Pathways Gene Silencing for Systems Biology Software, Databases, and Other Resources for Systems Biology Future Directions
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Biotechnology BESTSELLER!
Introduction to Biology and Biotechnology Second Edition K. Vaidyanath, K. Pratap Reddy, and K. Satya Prasad Osmania University, Hyderabad, India
Highlighting advances, this edition focuses on sustainable development and human welfare in biology, genetics, microbial biotechnology, and molecular medicine. While written for engineers specializing in biotechnology, those in agriculture, veterinary science, and medicine, will find new information relevant to their practice. The book links biological principles to plant, animal, environmental, industrial, and medical biotechnologies, discusses concepts of genetics and molecular biology, and examines developments in the production of biopolymers, vaccines, gene therapy, bioremediation, biofuels, and biofertilizers.
Contents: Introduction to Plant Science Introduction to Plant Biotechnology Introduction to Animal Science Biology of Parasites and Immune Response Introduction to Animal Biotechnology Introduction to Microbial Biotechnology General Bibliography Catalog no. N10069, 2009, 625 pp. ISBN: 978-1-4398-0724-8, $82.95
WINNER 2009 CHOICE AWARD OUTSTANDING ACADEMIC TITLE!
Fundamentals of Nanotechnology Gabor L. Hornyak, John J. Moore, H.F. Tibbals, and Joydeep Dutta “ . . . an outstanding, essential resource for anyone in the field, student or otherwise. It covers the entire spectrum of nanotechnology including nanoelectronics, photonics, nanocomposites, and thin films . . . This comprehensive, highly readable book with extremely high production values can be read and appreciated by experts and non specialists alike. A revolutionary book in a revolutionary field.” —B. Ransom, formerly, University of California, San Diego, in CHOICE
Accurately representing nanotechnology as both a sovereign field—and a convergence of many different disciplines—this book surveys the subject’s broad landscape. It explores topics such as nanorheology, nanofluidics, and nanomechanics, as well as industrial concerns including manufacturing, reliability, and safety. The authors address the vast range of nanomaterials and systematically outline devices and applications in various industrial sectors. This color text is an ideal companion to Introduction to Nanoscience, written by the same group of esteemed authors.
Features: • Provides a complete and integrated introduction to the engineering and application aspects of nanotechnology • Addresses the business and societal aspects of nanotechnology • Presents all illustrations in full color • Follows a consistent format of basic and advanced topics, examples, illustrations, exercises, and a summary Includes access to chapter-by-chapter ancillary material with qualifying course adoption
Abridged Contents: THE PERSPECTIVE THE ENGINEERING THE MATERIALS DEVICES AND APPLICATIONS OVERVIEW Catalog no. 48031, 2009, 786 pp. ISBN: 978-1-4200-4803-2, $89.95
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