Biomedical Engineering - April 2011 by CRC Press

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Contents Biomedical Engineering ....................................3 Medicine & Biology ..............................................6 Sensors & Instrumentation................................9 Industry Applications ......................................11 Biomechanics..................................................13 Page 3

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Biomedical Imaging ........................................14 Neuroscience ..................................................16 Bioprocessing..................................................19 Biomaterials & Medical Devices ......................21 Nanobiotechnology ........................................24

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Biomedical Engineering Coming Soon!

Biomedical Engineering Principles Second Edition Arthur B. Ritter, Vikki Hazelwood, and Antonio Valdevit Stevens Institute of Technology, Hoboken, New Jersey, USA

Alfred N. Ascione Alcatel-Lucent Technologies, New Jersey, USA

Integrating engineering, medicine, biology, and physics, this book clearly defines basic principles in image processing and biomechanics, modeling physiological processes, and bioelectric signal analysis to build a solid understanding of devices and designs for improved functioning of the human body. It includes cutting-edge discussions of tissue engineering, cardiovascular components, bone regrowth, and nerve regeneration. Other topics include technologies at the forefront of cardiac care, such as total artificial hearts, left ventricular assist devices, and stents, as well as issues related to minimally invasive and robotic surgery, next-generation imaging devices, and nanodevices.

Features: • Includes new chapters on capstone design in biomedical engineering and entrepreneurship • Contains new coverage of systems biology and computational biology • Provides extensively revised and updated chapters on the emerging field of tissue engineering • Offers extensive examples and in-chapter problems thoroughly updated and revised

Selected Contents Introduction: Modeling of Physiological Processes. Cell Physiology and Transport. Principles and Biomedical Applications of Hemodynamics. A Systems Approach to Physiology. The Cardiovascular System. Biomedical Signal Processing. Signal Acquisition and Processing. Techniques for Physiological Signal Processing. Examples of Physiological Signal Processing. Principles of Biomechanics. Practical Applications of Biomechanics. Biomaterials. Principles of Biomedical Capstone Design. Unmet Clinical Needs. Entrepreneurship: Reasons why Most Good Designs Never Get to Market. Catalog no. K10621, May 2011, 544 pp. ISBN: 978-1-4398-1232-7, $99.95 / £63.99

Biomedical Microsystems Ellis Meng University of Southern California, Los Angeles, USA

Written by an active researcher recently named one of Technology Review’s Young Innovators Under 35, this book begins with an introduction to the benefits of miniaturization. It introduces materials, fabrication technology, and the necessary components of all bioMEMS. The author covers fundamental principles and building blocks, including microfluidic concepts, lab-ona-chip systems, and sensing and detection methods. The final chapters explore several important applications of bioMEMS, such as microdialysis, catheter-based sensors, MEMS implants, neural probes, and tissue engineering.

Features: • Presents a rigorous, in-depth treatment of bioMEMS materials, methods, processes, and concepts • Emphasizes practical knowledge useful for application to real-world problems • Describes research and commercialized bioMEMS devices as well as emerging applications • Includes detailed examples, laboratory exercises, and a variety of homework problems • Contains numerous illustrations of concepts, processes, and devices • Offers downloadable original images for qualifying instructors at www.crcpress.com For readers with a limited background in MEMS and bioMEMS, this book provides a practical introduction to the technology used to make these devices, the principles that govern their operation, and examples of their application.

Selected Contents Introduction. BioMEMS Materials. Microfabrication Methods and Processes for BioMEMS. Microfluidics. Lab-on-a-Chip or Micro Total Analysis Systems. Sensing and Detection Methods. Applications to Cells, Nucleic Acids, and Proteins. Clinical Monitoring. MEMS Implants and Bioelectric Interfaces. Index. Solutions manual is available with qualifying course adoption.

Catalog no. 51229, January 2011, 408 pp. ISBN: 978-1-4200-5122-3, $89.95 / £49.99 Also available as an eBook

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Biomedical Engineering

BioMEMS Science and Engineering Perspectives Simona Badilescu and Muthukumaran Packirisamy

Handbook of Photonics for Biomedical Science Edited by

Valery V. Tuchin Saratov State University, Russia

Concordia University, Montreal, Canada

Series in Medical Physics and Biomedical Engineering

Covering often overlooked areas in the field of bioMEMS, this volume spans topics associated with biomolecules and complex biological entities, as well as subjects directly linked to the design, fabrication, and characterization of devices. Unlike other references, this text aids in the fundamental physiochemical understanding of biological processes relevant to the performance of various biosensing devices. Useful for upper-level undergraduate and graduate students enrolled in engineering programs, the book includes problems in each chapter, in addition to case studies that provide real-life examples. The book discusses:

Addressing problems in biomedical optics and biophotonics, this handbook describes advanced biophotonics methods and techniques intensively developed in recent years. It discusses optical and terahertz spectroscopy and imaging methods for biomedical diagnostics based on the interaction of coherent, polarized, and acoustically modulated radiation with tissues and cells. It covers modalities of nonlinear spectroscopic microscopies, photonic technologies for therapy and surgery, and nanoparticle photonic technologies for cancer treatment and UV radiation protection. The text also elucidates the advanced spectroscopy and imaging of normal and pathological tissues.

• Different materials and platforms used to develop biomicrosystems • Various biological entities and pathogens (in ascending order of complexity) • The multidisciplinary aspects of engineering bioactive surfaces • Engineering perspectives, including methods of manufacturing bioactive surfaces and devices • Microfluidics modeling and experimentation • Device level implementation of BioMEMS concepts for different applications. Because BioMEMS is an application-driven field, the book also highlights the concepts of lab-ona-chip (LOC) and micro total analysis system (µTAS), along with their pertinence to the emerging point-of-care (POC) and point-ofneed (PON) applications.

Selected Contents: Introduction. Solid Surfaces. Biomolecules and Complex Biological Entities: Structure and Properties. Engineering of Surfaces for Generating Bioactive Substrates. Methods of Study and Characterization of the Surface Modified Surfaces. Bio-sensing Fundamentals. Fabrication of BioMEMS Devices. Microfluidics. Microfluidic Devices. BioMEMS and its Life Science Applications. Catalog no. K10877, April 2011, 368 pp. ISBN: 978-1-4398-1699-8, $99.95 / £63.99

Catalog no. K10313, 2010, 868 pp. ISBN: 978-1-4398-0628-9, $149.95 / £95.00 Also available as an eBook

Introduction to Complexity and Complex Systems Robert B. Northrop University of Connecticut, Storrs, USA

Written for students and professionals in the fields of biomedical engineering, systems biology, biophysics, and physiology, this unique reference covers complexity issues within living systems. Topics include human responses to coping with complex systems, the Law of Unintended Consequences, the relation of complexity to evolution, the complexity inherent in invertebrate immune systems, and the complexity inherent in economic systems. A comprehensive glossary provides acronyms and terms relating to complex, nonlinear biological systems. Dynamic models and homework questions are also included to further aid in understanding. Catalog no. K11775, January 2011, 551 pp. ISBN: 978-1-4398-3901-0, $79.95 / £44.99 Also available as an eBook

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Biomedical Engineering Paediatric Rehabilitation Engineering From Disability to Possibility Edited by

Tom Chau

The Physiology of Bioelectricity in Development, Tissue Regeneration and Cancer

Bloorview Kids Rehab, Toronto, Canada

Edited by

Jillian Fairley

University of Leicester, UK

Series in Rehabilitation Science in Practice

This book describes the importance of biological electric fields and their use as tools to influence tissue repair, regeneration, and cancer. It considers the generation and measurement of these fields, intercellular communication regarding local electrical guidance cues, and the role of bioelectricity in tissue development, regeneration, wound repair, and cancer.

Innovations in paediatric rehabilitation engineering can serve as a springboard to education, psychosocial, social, physical and cognitive development for children and youth with disabilities. Instead of providing an overview of rehabilitation engineering, Paediatric Rehabilitation Engineering focuses on the uniqueness of the paediatric subspecialty via an international sampling of methods and techniques currently in use or in development.

It includes coverage of: • Microswitch-based occupational, recreational and rehabilitation programs • Emerging access technologies, like infrared thermal imaging and vocal cord vibration detection • Communication technologies to enable children to communicate in a variety of everyday environments • Accessible graphical user and Web-based interface design • Postural and upper and lower extremity compensation, such as customized chairs and prostheses • Global efforts in the area of robotics for autism research • Virtual reality and other interfaces to mitigate motor, communication, and physical control difficulties The book is divided into three complementary components. The first group of chapters is broadly concerned with connecting individuals to their environment and to the people around them. The second group revolves around paediatric technologies that compensate for compromised or missing function. The final group of chapters is about machines and environments which provide stimulating and interactive platforms for therapy and research. Catalog no. K10416, January 2011, 366 pp. ISBN: 978-1-4398-0842-9, $139.95 / £89.00 Also available as an eBook

Christine E. Pullar

Features: • Focuses on the most relevant topics poised to drive the next generation of medical breakthroughs • Demonstrates the role of bioelectricity in the directionality and speed of cell migration, proliferation, apoptosis, differentiation, and orientation • Discusses the role of bioelectricity in cancer progression and the potential for bioelectricitybased therapies to target both the tumor and metastatic cancer cells • Features contributions from world-class experts in the field • Includes clinical applications and extensive references to enhance additional study

Selected Contents: Measuring Endogenous Electric Fields. Investigation Systems to Study the Biological Effects of Weak Physiological Electric Fields. Endogenous Bioelectric Signals as Morphogenetic Controls of Development, Regeneration, and Neoplasm. Stem Cell Physiological Responses to Noninvasive Electrical Stimulation. Electrical Signals Control Corneal Epithelial Cell Physiology and Wound Repair. Physiological Electric Fields Can Direct Keratinocyte Migration and Promote Healing in Chronic Wounds. Electrical Control of Angiogenesis. Inflammatory Cell Electrotaxis. Effects of DC Electric Fields on Migration of Cells of the Musculoskeletal System. Neuronal Growth Cone Guidance by Physiological DC Electric Fields. Can Applied Voltages Be Used to Produce Spinal Cord Regeneration and Recovery in Humans? Catalog no. K11686, March 2011, 342 pp. ISBN: 978-1-4398-3723-8, $119.95 / £76.99 Also available as an eBook

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Medicine & Biology Basic Introduction to Bioelectromagnetics

Coming Soon!

Second Edition

Edited by

Cynthia Furse, Douglas A. Christensen, and Carl H. Durney

David A. Boas Constantinos Pitris, and Nimmi Ramanujam

Handbook of Biomedical Optics

University of Utah, Salt Lake City, USA

Duke University, Durham, North Carolina, USA

This revised and updated, edition facilitates the process of interdisciplinary research by introducing life scientists to the basic concepts of electromagnetic fields. The book outlines elements of EM that are helpful to life scientists working with physicists and electrical engineers. Each concept is presented with an associated application and discussion. Example applications include MRI, NMR, ultrasound, hyperthermia, neural stimulation, and cardiac pacing/defibrillation. With the liberal use of diagrams and graphs, this text covers the entire frequency spectrum through optical frequencies from a qualitative perspective beneficial to life scientists.

Taking a broad yet detailed approach, this comprehensive handbook covers light-based diagnostic methodologies and light-mediated therapeutics both as conceptually and as cutting-edge optical methods used in research and practice. Extensively illustrated, the book presents the theory and fundamentals, along with state-of-theart applications. The expert contributors also discuss advantages and disadvantages of various techniques. After introducing the background principles of optics, light sources, and irradiation and basic tissue optics concepts, the book focuses on spectroscopic methods, tomographic imaging, microscopic imaging methods, molecular probe development, and phototherapy.

Catalog no. 55429, 2009, 288 pp. ISBN: 978-1-4200-5542-9, $102.95 / £65.99 Also available as an eBook

Signals and Systems Analysis In Biomedical Engineering Second Edition Robert B. Northrop University of Connecticut, Storrs, USA Series: Biomedical Engineering

Biomedical engineering requires its practitioners to master not only engineering skills, but also a diversity of material in the biological sciences. Based on the author's years of experience in teaching as well as his personal research on neurosensory systems, this book provides a ready source of information on the specialized mathematical techniques most useful in describing and analyzing biomedical signals, including ECG, EEG, blood pressure, biochemical spectrograms, and tomographic images. A solutions manual is available with qualifying course adoption

Catalog no. K10633, 2010, 654 pp. ISBN: 978-1-4398-1251-8, $99.95 / £48.99 Also available as an eBook

Catalog no. 90364, June 2011, c. 852 pp. ISBN: 978-1-4200-9036-9, $149.95 / £95.00

Digital Microfluidic Biochips Design Automation and Optimization Krishnendu Chakrabarty Duke University, Durham, North Carolina, USA

Tao Xu Cisco Systems, Cary, North Carolina, USA

Microfluidics-based biochips combine electronics with biochemistry for emerging application areas such as point-of-care medical diagnostics, on-chip DNA analysis, automated drug discovery, and protein crystallization. This book envisions an automated design flow for microfluidic biochips. It offers newly designed automation solutions for problems unique to digital microfluidics. The authors provide a comprehensive methodology for the automated design, test, and use of robust and low-cost manufactured digital microfluidic systems. Using real-life bioassays as examples, they offer a comprehensive set of practical methodologies and tools for chip design and manufacture. Catalog no. K11010, 2010, 213 pp. ISBN: 978-1-4398-1915-9, $139.95 / £89.00 Also available as an eBook

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Medicine & Biology

Mechanobiology Handbook Edited by

Jiro Nagatomi Clemson University, South Carolina, USA

At appropriate levels, mechanical stimuli are necessary for growth and maintenance of healthy tissues and organs. Mechanobiology examines effects of mechanical force stimuli on cellular biological functions. The past two decades have seen a dramatic increase in the level of research in mechanobiology. Collecting the cutting-edge research findings from a diverse range of scientists, this volume, which presents basic materials in mechanics and cell biology, is a reference for those new to the field and is designed to stimulate new ways of thinking in current mechanobiology researchers.

Features: • Presents research data and viewpoints from diverse fields of mechanobiology • Includes background information in mechanics and cell biology • Explores application areas such as tissue engineering • Contains references at the end of each chapter to facilitate further study

Selected Contents: Basic Science Tools for Mechanobiology Research: Primer of Biomechanics. Primer of Molecular Cell Biology. Literature Review of Mechanobiology Research Findings and Theories: Mechanobiology in Musculoskeletal Systems. Mechanobiology in Cardiovascular Systems. Mechanobiology in other Organ Systems. Applications of Mechanobiology. Catalog no. 91212, March 2011, 563 pp. ISBN: 978-1-4200-9121-2, $169.95 / £109.00 Also available as an eBook

Biology for Engineers Arthur T. Johnson University of Maryland, College Park, USA

Introducing the field of biology to today’s engineering students, this entry-level text minimizes unnecessary memorization of connections and classifications and emphasizes concepts, technology, and the utilization of living things. Filled with practical examples, the book discusses biological responses from the perspectives of psychology, human factors, genetics, plant and animal physiology, imaging, control systems, actuary, and medicine. Offering numerous tables of useful information, it covers the scaling of biological responses and attributes as well as different types of applications related to biological systems.

Features: • Explores areas in physics, chemistry, mathematics, and engineering relating to biology • Introduces concepts and terminology needed to understand more advanced biology literature • Examines the differences between biological engineering and biological science • Includes a chapter on scaling relations showing how size effects other physical characteristics • Surveys a broad range of application areas

Selected Contents: Introduction. Principles from the Sciences: Principles of Physics. Principles of Chemistry. Principles of Mathematics and Engineering Sciences. Principles of Biology. Responses of Living Systems: Biological Responses in Context. Scaling Factors: Allometric Relationships from Evolutionary Pressure. Utilizing Living Systems: Systems Approach. Appendices. References. Indexes. A solutions manual is available with qualifying course adoption

Catalog no. 77635, January 2011, 775 pp. ISBN: 978-1-4200-7763-6, $99.95 / £44.99 Also available as an eBook

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Medicine & Biology Handbook of Physics in Medicine and Biology Edited by

Robert Splinter University of North Carolina at Charlotte, USA

“The handbook includes hundreds of diagrams, images and tables, making it a useful tool for both medical physicists/engineers and other medical/biology specialists … includes materials that are rarely combined together, which strengthens its interdisciplinary approach.” —Physics in Medicine and Biology, 55, 2010

“My deep impression is this is an excellent work by a highly competent team. The book chapters follow logically from the properties of the cell membrane through sensors and electroreception, biomechanics and fluid dynamics to the recording of bioelectrical signals, bioelectric impedence analysis, x-ray and computed tomography, magnetic resonance imaging, nuclear medicine, ultrasonic and thermographic imaging … keep this book close at hand and do not hesitate to use it frequently.”

Advanced Electroporation Techniques in Biology and Medicine Andrei G. Pakhomov, Damijan Miklavcic, and Marko S. Markov During the last several decades, intense study has taken place on the effects of electromagnetic fields on living tissues. Reflecting this inquiry, this book discusses the theoretical and experimental evidence of these electromagnetic fields and electric pulses and examines their importance in medicine and biology. The authors present the basic techniques applied in electroporation and the advanced methods for creation of nanopores, highlighting their basic science and clinical applications. Topics include nano electroporation, classic electroporaiton, experimental evidence for electroporation of living cells, and electroporation for cancer and wound healing.

Features:

• Discusses the technology used in medical practice emphasizing regenerative approaches

• Discusses the contemporary physical chemical theory of membrane electroporation • Reviews the application of dyes and fluorescent probes to test the efficiency and selectivity of the molecular transport through permeabilized membranes • Describes a recently proposed molecular dynamics method of membrane electroporation that better "mimics" the experimental conditions, therefore avoiding several shortcomings and supplementing the electric field method • Examines the impact of physical parameters of the applied electric field on the efficiency of electroporation and its applications • Covers the basic processes and biophysical mechanism of electrically mediated gene transfer • Reviews the results and experience with electrochemotherapy of cancer in animal models and in humans

Selected Contents:

Anatomical Physics. Physics of Perception. Biomechanics. Electrical Physics. Diagnostic Physics. Physics of Accessory Medicine. Physics of Bioengineering.

Basics of Electroporation. Mechanisms of Electroporation. Mechanisms of Electroporation of Cells. Mechanisms of Electroporations in Tissues. Technical Considerations. Applications of Electroporation.

—BioMedical Engineering OnLine, 2010

Features: • Provides comprehensive treatment of the physics and physical chemistry of biological organisms, as well as the physics of imaging and diagnostics • Offers detailed coverage of physics related to human physiology alongside quantitative aspects of diagnostic and therapeutic technologies • Covers physics related to normal and pathological physiological functions, including fluid dynamics (blood-flow, cardiovascular system), mechanisms (muscle contraction) and electronics (cellular electrical activity, senses)

Catalog no. 75241, 2010, 548 pp. ISBN: 978-1-4200-7524-3, $149.95 / £95.00 Also available as an eBook

Catalog no. K11005, 2010, 528 pp. ISBN: 978-1-4398-1906-7, $139.95 / £89.00 Also available as an eBook

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Sensors & Instrumentation Biomedical Sensors and Instruments Waseda University, Tokorozawa, Saitama, Japan

Semiconductor Device-Based Sensors for Gas, Chemical, and Biomedical Applications

Toshiyo Tamura

Edited by

Chiba University, Japan

P. Ake Oberg

Fan Ren and Stephen J. Pearton

Linköping University, Sweden

University of Florida, Gainesville, USA

The living body is a difficult object to measure: accurate measurements of physiological signals require sensors and instruments capable of high specificity and selectivity that do not interfere with the systems under study. As a result, detailed knowledge of sensor and instrument properties is required to be able to select the "best" sensor from one of the many designed to meet these challenges.

“This book provides a missing critical piece in the sensor literature. Until now, a scientist or engineer could only read general-interest books in the sensor area; a practitioner was forced to scour through piles of research articles to find the details on state-of-the-art sensor technology. This work by Pearton and Ren brings together the theory and experimental descriptions of advanced sensor technology in one book. ... a must have for any engineer or scientist working in the chemical, gas, or biological sensor field. … The editors have written hundreds of excellent research and review articles, and the chapter authors are the preeminent scientists in the sensor field”

Second Edition Tatsuo Tagawa

• The organization of topics makes it easy to find the best possible choice of sensors for each measurement situation • More than 300 updated figures and tables facilitate an intuitive understanding • Numerous examples of sensor applications demonstrate practical methods of research • References at the end of each chapter provide convenient sources for further study From the underlying principles to practical applications, this updated edition of Biomedical Sensors and Instruments provides an easy-tounderstand introduction to the various kinds of biomedical sensors. The book presents state-ofthe-art discussions of sensors for the measurements of pressure, flow, motion, temperature, heat flow, evaporation, biopotential, biomagnetism, and chemical quantities.

— Michael Mastro, US Naval Research Lab

“Semiconductor sensors are playing an important role in broad range of applications. This book is edited by two internationally renowned scientists in the field of semiconductors and sensors. ... covers a broad range of wide bandgap semiconductor based sensors. Book chapters are very comprehensive and cover recent developments in the field by leading experts. ... an excellent reference volume for experts and new comers of the field. This book is very timely and covers broad topics of international interest.” — Chennupati Jagadish, Australian National University

Selected Contents:

Fundamental Concepts: Signals and Noise in the Measurement. Characteristics of the Measurement System. Determination of Absolute Quantity. Units of Measurement Quantities. Pressure Measurements: Direct Pressure Measurement. Indirect Pressure Measurement. Flow Measurement: Blood Flow Measurements in Single Vessels. Tissue Blood Flow Measurement. Respiratory Gas Flow Measurements. Motion and Force Measurement: Motion Measurements.

AlGaN/GaN Sensors for Direct Monitoring of Nerve Cell Response to Inhibitors. Recent Advances in Wide Bandgap Semiconductor Biological and Gas Sensors. Advances in Hydrogen Gas Sensor Technology and Implementation in Wireless Sensor Networks. InN-Based Chemical Sensors. ZnO Thin Film and Nanowire Based Sensor Applications. Bio-Affinity Sensors Based on MOS Field-Effect Transistors. MEMS-Based Optical Chemical Sensors.

Catalog no. 9078X, March 2011, 423 pp. ISBN: 978-1-4200-9078-9, $139.95 / £89.00

Catalog no. K10716, April 2011, 302 pp. ISBN: 978-1-4398-1387-4, $149.95 / £95.00

For more information and complete contents, visit www.crcpress.com

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Sensors & Instrumentation 3D Cell-Based Biosensors in Drug Discovery Programs Microtissue Engineering for High Throughput Screening William S. Kisaalita University of Georgia, Athens, USA

This book provides information — from theory to practice — on challenges and opportunities for incorporating 3D cell-based biosensors or assays in drug discovery programs. It supplies a historical perspective and defines the problem 3D cultures can solve. It also discusses how genomics and combinatorial chemistry have changed the way drug are discovered and presents data from the literature to underscore the less-than-desirable pharmaceutical industry performance under the new paradigm.

Features: • Provides a deep comparative analysis of 2D and 3D cultures • Uses data from peer-reviewed publications to conclusively provide the justification for use of 3D cell cultures in cell-based biosensors (assays) for high throughput screening • Includes difficult-to-find information such as patents, cell lines or types commonly used in drug discovery programs, and their origins • Addresses research needs mainly in areas of detection and scaffold engineering • Describes microenvironment factors for creating phenotypes that resemble their in vivo counterparts • Incorporates case studies in support of 3D cell-based biosensor adoption in drug discovery programs

Sensors for Chemical and Biological Applications Edited by

Manoj Kumar Ram Venkat R. Bhethanabotla University of South Florida, Tampa, USA

This reference supplies versatile, hands-on tools for professionals working in a broad array of disciplines. It offers a detailed discussion of the potential of chemical and biochemical sensors in medical science, food quality, biological, and environmental applications. Examining the role of nanotechnology in sensor development, it explores how sensors confront challenges of chemical-bioterrorism. It also includes practical examples of sensor usage such as cholesterol monitoring along with extensive references.

Features: • Provides a comprehensive overview of chemical and biochemical sensors • Covers applications of the solid-state gas sensor in the control and monitoring of chemical processes and living environments • Discusses the increasing importance of micro electromechanical systems (MEMS) and acoustic wave (SAW) in sensor applications • Explores the importance of biosensor in the measurement of food quality and environmental quality • Includes coverage of advanced techniques for detection of bio-chemical warfare agents

Selected Contents:

Introduction: Biosensors and Bioassays. TargetDriven Drug Discovery. 3D versus 2D Cultures. Comparative Genomics and Proteomics. Comparative Structure and Function. Emerging Design Principles: Chemical Microenvironmental Factors. Spatial and Temporal Microenvironmental Factors. Material Physical Property and Force Microenvironmental Factors. Proteomics as a Promising Tool in the Search for 3D Biomarkers.

Solid-State Gas Sensors. Conducting Polymer and Nanocomposite Membrane as Chemical Sensors. Detection of Volatile Organic Compounds: The Role of Tetrapyrrole Pigment-Oriented Thin Films. Modeling of Surface Acoustic Wave Sensor Response. Recent Advances in the Development of Sensors for Toxicity Monitoring. Application of Electronic Noses and Tongues. Applications of Sensors in Food and Environmental Analysis. Electronic Nose Applications in Medical Diagnose. DNA Biosensor for Environmental Risk Assessment and Drugs Studies. Methods of Detection of Explosives: As Chemical Warfare Agents. Detection and Identification of Organophosphorus Compounds: As Chemical Warfare Agents.

Catalog no. 73494, 2010, 404 pp. ISBN: 978-1-4200-7349-2, $129.95 / £82.00 Also available as an eBook

Catalog no. 3366, 2010, 390 pp. ISBN: 978-0-8493-3366-8, $129.95 / £82.00 Also available as an eBook

Selected Contents:

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Sensors & Instrumentation Semiconductor Radiation Detection Systems Edited by

Krzysztof Iniewski CMOS Emerging Technologies Inc., Vancouver, British Columbia Series: Devices, Circuits, and Systems

An essential resource for anyone serious about detectors and electronics in the healthcare sector, this book addresses the design of semiconductor detectors and integrated circuits in the context of medical imaging using ionizing radiation. It includes exciting opportunities in X-ray detection, Computer Tomography (CT), bone dosimetry, and nuclear medicine applications such as PET and SPECT. In addition to medical imaging, the book explores other applications of semiconductor radiation detection systems in areas related to security, such as luggage scanning, dirty bomb detection, and border control. Catalog no. K10214, 2010, 400 pp. ISBN: 978-1-4398-0385-1, $149.95 / £95.00 Also available as an eBook

Industry Applications

Clinical Procedures for Medical Technology Specialists Laurence J. Street Chilliwack General Hospital, Rosedale, British Columbia, Canada

As healthcare becomes more complex, the integration of all members of the team becomes even more important. Part of this integration requires that all team members have a grasp of the fundamentals of the medical and surgical treatments they are involved in. Written specifically for paramedical professionals who support doctors and nurses, Clinical Procedures for Medical Technology Specialists presents a clear and concise description of the more common diagnostic and treatment procedures used in current medical care.

Features • Describes a comprehensive range of diagnostic and treatment clinical procedures • Presents the information in an encyclopedic format with entries in alphabetical order using a common name

A First Course in Differential Equations, Modeling, and Simulation Carlos A. Smith and Scott W. Campbell University of South Florida, Tampa, USA

Overcoming some of the drawbacks in standard differential equations courses, this text illustrates the development of dynamic models using basic physics and analytical solution and simulation methods. Taking a rigorous yet practical approach, the authors clearly explain how to solve differential equations, and emphasize the integration of modeling and simulation. The book develops models of physical systems, before obtaining the analytical solution and performing simulations. The examples and problems provided apply real-world design experience. Catalog no. K12318, May 2011, 345 pp. ISBN: 978-1-4398-5087-9, $89.95 / £57.99

• Covers pre-procedure prerequisites, the procedure itself, expected outcomes, and possible complications • Provides background material such as relevant anatomy and physiology details, normal clinical values, descriptions of medical devices, and reference information While a great many texts describe medical and surgical procedures, there are few, if any, aimed at the large, diverse group of professionals who directly support the medical system. Moreover, these sources tend to have more detail than is required for a paramedical professional. Carefully organized in an encyclopedic format that allows easy access to just the right amount of information, this book supplies nonclinical members of the modern integrated healthcare team with a more complete perspective of the clinical experiences of the clients of the system: the patients. Catalog no. 81993, January 2011, 344 pp. ISBN: 978-1-4200-8199-2, $69.95 / £44.99 Also available as an eBook

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Industry Applications Coming Soon!

Healthcare Sensor Networks Challenges Toward Practical Implementation Edited by

Daniel Tze Huei Lai, and Rezaul Begg Victoria University, Melbourne, Australia

Marimuthu Palaniswami University of Melbourne, Parkville, Victoria, Australia

From network deployment to secure monitoring, this book addresses the latest developments in healthcare sensor networks—medical monitoring devices implanted on the body or in the surrounding infrastructure. The text discusses fundamental concepts and provides examples of clinical applications, including fall prevention for the elderly and children with cerebral palsy. Each chapter details a separate challenge in design and implementation. The book addresses higher data bandwidth demand, longer network operational time, robust network design in dynamic environments, and lower costs versus high computational demand.

Features: • Looks at the implementation of sensor network technology in healthcare, including body sensor networks and personal area networks • Presents new solutions to human motion monitoring with sensors, including computational intelligence approaches • Addresses challenges in implementing healthcare sensor networks, such as user acceptance and expectations • Discusses novel security measures for protecting confidential patient data, including encryption methods and information hiding techniques • Offers practical case studies of healthcare sensor networks in use

Selected Contents: Introduction to Healthcare Sensor Networks. New Algorithms for Improving Inertial Sensor Measurements. New Sensors for Measuring Human Locomotion and Physiology. Advance Onboard Signal Processing Algorithms for Healthcare Sensor Motes. Deploying Computational Intelligence in Healthcare Sensor Networks. Middleware in Healthcare Sensor Networks. Data Transmission Schemes for Healthcare Sensor Networks. Catalog no. K11159, October 2011, c. 512 pp. ISBN: 978-1-4398-2181-7, $149.95 / £95.00

Quality Control Training Manual Comprehensive Training Guide for API, Finished Pharmaceutical and Biotechnologies Laboratories Syed Imtiaz Haider and Erfan Asif Syed Julphar Gulf Pharm Industries, United Arab Emirates

Written to help companies comply with GMP, GLP, and validation requirements imposed by the FDA and regulatory bodies worldwide, Quality Control Training Manual: Comprehensive Training Guide for API, Finished Pharmaceutical and Biotechnologies Laboratories presents cost-effective training courses that cover how to apply advances in the life sciences to produce commercially viable biotech products and services in terms of quality, safety, and efficacy. This book and its accompanying CD-ROM comprise detailed text, summaries, test papers, and answers to test papers, providing an administrative solution for management.

Features: • Provides the FDA, Health Canada, WHO, and EMEA guidelines directly applicable to pharmaceutical laboratory-related issues • Offers generic formats and styles that can be customized to any organization and help management build quality into routine operations to comply with regulatory requirements • Contains ready-to-use training courses for experienced and inexperienced practitioners in the biotechnology/biopharmaceutical industries • Training courses on the included CD supply valuable tools for developing training matrices to achieve FDA, Health Canada, EMEA, MHRA UK, WHO, and GLP compliance. • Supplies ready-to-use test papers that allow end users to record all raw data up to the issuance of the attached certificate The biotechnology/bioscience industries are regulated worldwide to be in compliance with cGMP and GLP principles, with particular focus on safety issues. The training procedures in this book enable end users to understand the principles and elements of manufacturing techniques and provide documentation language ranging from the generic to the specific. Catalog no. K12268, February 2011, 484 pp. ISBN: 978-1-4398-4994-1, $139.95 / £89.00 Also available as an eBook

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Biomechanics

Biomechanics of the Upper Limbs Mechanics, Modeling and Musculoskeletal Injuries, Second Edition Andris Freivalds

Principles of Biomechanics Ronald L. Huston University of Cincinnati, Ohio, USA

Pennsylvania State University, University Park, USA

Series: Dekker Mechanical Engineering

There is already a wealth of literature covering cumulative trauma disorders and medical management, as well as the biomechanics of manual material handling and lower back problems. However, despite a spike in the number of workrelated musculoskeletal disorders (WRMSDs) in the upper limbs—due to a sharp increase in the amount of computer-related jobs—few if any books have focused exclusively on WRMSDs, until now. Biomechanics of the Upper Limbs: Mechanics, Modeling and Musculoskeletal Injuries, Second Edition offers vital information and tools to improve analysis of external forces and their effects on the human body. This can help ergonomists better understand job stressors and the role they play in the development of disorders, enabling them to modify the work environment and educate practitioners to better control harmful situations. Using the author’s medical and engineering expertise to distill essential subject matter and useful technical data, this comprehensive text explores:

Presenting the fundamental concepts that are required for further research in this field, this volume emphasizes biodynamic modeling and human body models. Beginning with a review of gross human anatomy and a summary of basic terminology, it describes various methods of analysis, including elementary mathematics, elementary mechanics, and the mechanics of materials. Later chapters discuss the modeling of biosystems, tissue biomechanics, biodynamics, kinematics, kinetics, and the inertial properties of human body models. The book concludes with a review of sample applications of biodynamic models in activities such as lifting, maneuvering in space, walking, and swimming.

• Biomechanics of the upper limbs and the motor control system • The structure and physiology of the human musculoskeletal and neuromuscular systems • Recent research findings and solutions to various ergonomic problems • Models of various components of the neuromuscular systems, as well as larger systems in the upper limbs • Risk factors for disorders and tools used to identify their causes An ancillary website offers materials such as PowerPoint® slides, sample exams, and an instructor's manual with complete solutions. It also serves as a practical, up-to-date, engineering-oriented resource for researchers, industrial ergonomists, industrial hygienists, and medical professionals who require supplementary material. Catalog no. 91190, February 2011, 564 pp. ISBN: 978-1-4200-9119-9, $119.95 / £76.99 Also available as an eBook

Features: • Focuses on fundamental principles in biosystems and the human body • Discusses biosystem modeling and elementary mechanics • Includes examples and problems to clarify material • Provides the basis for advanced study, research, and practice in biomechanics

Selected Contents: Introduction. Review of Human Anatomy and Some Basic Terminology. Methods of Analysis I: Review of Vectors, Dyadics, Matrices, and Determinants. Methods of Analysis II: Forces and Force Systems. Methods of Analysis III: Mechanics of Materials. Methods of Analysis IV: Modeling of Biosystems. Tissue Biomechanics. Kinematical Preliminaries: Fundamental Equations. Kinematic Preliminaries: Inertia Force Considerations. Human Body Inertia Properties. Kinematics of Human Body Models. Kinetics of Human Body Models. Dynamics of Human Body Models. Numerical Methods. Simulations and Applications. Appendix A. Anthropometric Data Tables. Glossary. Bibliography. Index. Catalog no. DK494X, 2009, 442 pp. ISBN: 978-0-8493-3494-8, $109.95 / £69.99 Also available as an eBook

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Biomechanics Foot and Ankle Motion Analysis Clinical Treatment and Technology Gerald F. Harris Marquette University, Milwaukee, Wisconsin, USA

Peter A. Smith

Biomechanical Imaging Data Mining in Biomedical Imaging, Signaling, and Systems Edited by

Sumeet Dua

Shriner’s Hospital for Children, Chicago, Illinois, USA

Louisiana Tech University, Ruston, USA

Richard M. Marks

Rajendra Acharya U

Medical College of Wisconsin, Milwaukee, USA Series: Biomedical Engineering

Originating as a workshop sponsored by the Shriner’s Hospitals and the National Institutes of Health, this text is a single source reference for assessment technologies and their clinical applications. Presenting basic and advanced clinical applications in pediatric and adult cases, the book also introduces the technological advances themselves from a quantitative perspective. It describes approaches related to mechanical paradigms, imaging, kinetics, robotics and simulation, tri-planar force sensing, and more. Catalog no. 3971, 2008, 704 pp. ISBN: 978-0-8493-3971-4, $199.95 / £127.00 Also available as an eBook

Ngee Ann Polytechnic, Singapore

Approaching the techniques and challenges of image mining from a multidisciplinary perspective, this book presents data mining techniques, methodologies, algorithms, and strategies to analyze biomedical signals and images. Written by experts in the field, the text addresses data mining paradigms for the development of biomedical systems. It also includes special coverage of knowledge discovery in mammograms and emphasizes both the diagnostic and therapeutic applications of eye imaging. Catalog no. K11798, May 2011, 448 pp. ISBN: 978-1-4398-3938-6, $109.95 / £66.99

Principles and Applications, Second Edition

Automated Image Detection of Retinal Pathology

Edited by

Herbert Jelinek

Biomechanics

Donald R. Peterson University of Connecticut, Farmington, USA

Joseph D. Bronzino Trinity College, Hartford, Connecticut, USA

Medical University of Vienna, Austria

Michael J. Cree University of Waikato, Hamilton, New Zealand

Drawn from the third edition of The Biomedical Engineering Handbook, this volume is a comprehensive presentation that integrates systems and subsystems models. With substantial updates, revisions and a new chapter on methods and strategies for modeling cellular mechanics, the book covers musculoskeletal mechanics, biofluid mechanics and circulatory dynamics, the functioning of the ear, and the performance characteristics of the human body during exercise and exertion. Illustrations, tables, and equations assist in modeling biomechanical behaviors.

Offering an array of informative examples, this book analyzes the use of automated computer techniques, such as pattern recognition, in analyzing retinal images and detecting diabetic retinopathy and its progression as well as other retinal-based diseases. It also addresses the benefits and challenges of automated health care in the field of ophthalmology. The book then details the increasing practice of telemedicine screening and other advanced applications including arteriolar-venous ratio, which has been shown to be an early indicator of cardiovascular, diabetes, and cerebrovascular risk.

Catalog no. 8534, 2008, 352 pp. ISBN: 978-0-8493-8534-6, $99.95 / £63.99 Also available as an eBook

Catalog no. 7556, 2010, 384 pp. ISBN: 978-0-8493-7556-9, $144.95 / £92.00 Also available as an eBook

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Biomechanical Imaging

Coming Soon!

Diffuse Optical Tomography

Essentials of Functional MRI

Principles and Applications

Patrick W. Stroman

Huabei Jiang

Queen's University, Kingston, Ontario, Canada

"A comprehensive book, combining a strong theoretical background with profound practical hints for the use of fMRI in medical research.... represents a major step forward." —Massimo Filippi, M.D., Department of Neurology, Scientific Institute HSR, Italy

"I find the book packed with information. It will be useful for both a clinical audience and MR technologists." —W. Einar Mencl, Ph.D., Director of Neuroimaging Research, Haskins Laboratories and Yale University, New Haven, Connecticut

This book presents a solid, practical foundation for readers to become conversant with functional MRI (fMRI) as a tool for their own research and practice. The author reviews applications for disease diagnosis, treatment monitoring, and surgical planning. He also covers the underlying biophysical mechanisms that relate MRI changes to neuronal activity as well as the expanded use of fMRI beyond the brain to the brainstem and spinal cord.

University of Florida, Gainesville, FL, USA

Offering a concise description of the particular problems involved in optical tomography, this reference illustrates Diffuse Optical Tomagraphy (DOT)’s fundamental foundations and the principle of image reconstruction. It thoroughly explores computational methods, forward mathematical models, and inverse strategies, clearly illustrating solutions to key equations. This reference outlines how to use DOT to create experimental image systems and adapt the results of laboratory studies for use in clinical applications including:

• Full-color interior with more than 130 figures • Comprehensive glossary reviews the extensive jargon used in the field • Detailed examples • Explains how to design and analyze an fMRI study • Provides an overview alternative fMRI methods • Discusses fMRI of the cortex as well as the brainstem and spinal cord

• Early-stage detection of breast tumors and prostate cancer • "Real-time" functional brain imaging • Joint imaging to treat progressive diseases such as arthritis • Monitoring of tumor response • New contrast mechanisms and multimodality methods This book covers almost every aspect of DOT— including reconstruction algorithms based on nonlinear iterative Newton methods, instrumentation and calibration methods in both continuous-wave and frequency domains, and important issues of imaging contrast and spatial resolution. It also addresses phantom experiments and the development of various image-enhancing schemes, and it describes reconstruction methods based on contrast agents and fluorescence DOT.

Selected Contents:

Introduction. Basic Concepts. Source of the MR Signal and Its Properties. The Fundamental Building Blocks of MR Imaging Methods: Spin-Echoes and Gradient-Echoes. Creating an Image from the MR Signal. Principles and Practice of fMRI. fMRI Study Design. fMRI Data Analysis. Clinical Applications of fMRI. Supplementary MRI Methods. Glossary. Appendices.

Introduction. Reconstruction Algorithms. Instrumentation and Calibration Methods. Contrast, Spatial Resolution, and Uniqueness of Inverse Solution. Image Enhancement Schemes. Fluorescence and Bioluminescence DOT. New Contrast Mechanisms and Multi-Modality Approaches. Clinical Applications and Animal Studies.

Catalog no. K10992, June 2011, 304 pp. Soft Cover, ISBN: 978-1-4398-1878-7 $79.95 / £49.99

Catalog no. K12111, January 2011, 375 pp., ISBN: 978-1-4398-4757-2, $129.95 / £82.00 Also available as an eBook

Features:

For more information and complete contents, visit www.crcpress.com

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Neuroscience Coming soon!

Neurobiology of Sensation and Reward Jay A. Gottfried Northwestern University, Chicago, Illinois, USA Series: Frontiers in Neuroscience

A comprehensive systems overview of sensory and reward processing in the brain, this book explores what reward processing can teach us about the senses and what sensory processing can teach us about reward. In examining the neurobiological interface between sensation and reward, the book reveals how the instrinsic properties of sensory systems effectively define and constrain the ambitions of reward-related processing in human and non-human brains. With contributions from leading investigators in the fields of sensation and reward, the text injects the "sensory" back into the study of reward processing, and the "rewarding" back into the study of sensory processing.

Concussive Brain Trauma Neurobehavioral Impairment & Maladaptation, Second Edition Rolland S. Parker New York University School of Medicine, USA

Continuing the tradition of the bestselling first edition, this second edition provides comprehensive coverage of neurobehavioral disorders in children and adults following impact and acceleration accidents. Completely revised and updated, the book includes comprehensive coverage of consciousness including normal, acute, and persistent alterations. Drawing on his training, education, and experience in human physiology, neuroanatomy, and endocrinology, the author not only gives readers a solid foundation for understanding, diagnosing, and treating concussive brain trauma, but also gives them tools to increase standards of care.

Features:

Features: • Introduces sensation and reward from a multidisciplinary perspective that includes biology, ecology, evolution, and the history of neuroscience • Presents critical links between basic and clinical neuroscience through the latest behavioral and pathological findings in humans with behavioral and cognitive impairments in sensation and reward processing • Explores the non-human and human brains, and the very human rewards of art, perfume, and music • Discusses how the processing of sensations benefits from the presence of the brain

Selected Contents: First Principles: A Brief History of Sensation and Reward. A Systems Organization of the Senses. From Sensation to Reward. Civilized Sensory Rewards (Distinctly Human Rewards). Catalog no. 67265, March 2011, 466 pp. ISBN: 978-1-4200-6726-2, $149.95 / £95.00

• Describes neurobehavioral disorders in children and adults following impact and acceleration accidents • Covers consciousness, including normal, acute, and persistent alterations • Discusses personality and subjective complaints and symptoms • Includes six new chapters and new material on dysregulation of the internal environment

Selected Contents Concussion: Not Always "Minor" Head Injury. Introduction to the Postconcussion Syndrome. The Central Nervous System: Organization of Behavior. Acute Alterations of Consciousness. The Internal Milieu: Brain and Body. Biomechanics and Tissue Injuries. Acute Brain and Somatic Injury. The Acute Stress Response. Chronic Posttraumatic Stress: Injury, Disease, and Burnou. Comorbid Posttraumatic Stress Disorder and Concussion. Disorders of Sensation, Motion, and Body Schema. Vocal Motor Disorders. Chronic Pain and Posttraumatic Headaches. Chronic Posttraumatic Disorders of Consciousness. Cognition, Language, and Intelligence. Posttraumatic Personality Disorders. Children’s Brain Trauma. Outcome and Treatment: Concussive Trauma. Catalog no. 8039, October 2011, c. 976 pp. ISBN: 978-0-8493-8039-6, $159.95 / £99.00

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Neuroscience Epilepsy The Intersection of Neurosciences, Biology, Mathematics, Engineering, and Physics Edited by

Ivan Osorio, Hitten Zaveri, Mark G. Frei, and Susan Arthurs Epilepsy, one of the most prevalent neurological disorders, affects approximately 1% (greater than 60 million) of the world's population. In an estimated 20 million of these patients, seizures are not controlled even by multiple anti-seizure drugs, and are extremely difficult to predict. This book seamlessly brings together the neurosciences, mathematics, computational sciences, engineering, physics, and clinical epileptology to present to readers a highly didactic, integrated, clear, and useful knowledge base and research directions. Laying out the foundations of signal analysis, data conditioning, linear and non-linear analysis, and introducing dynamical systems and fundamental anatomical and neurophysiological concepts, this book: • Introduces non-physicians to language and concepts necessary to establish a meaningful dialog with epileptologists • Introduces physicians to dynamical theory and signal processing without which interdisciplinary collaborations would not be productive • Mines knowledge from fields devoted to the investigation of aperiodic paroxysmal relaxation phenomena, such as earthquakes, which bear dynamical similarities with epilepsy, so as to lay the proper scientific foundations for epileptology and foster much needed therapeutic advances efficiently • Reviews spatiotemporal behavior of seizures, mechanisms of epileptogenesis and ictogenesis as well as of seizure control and ancillary technology • Calls attention to nocturnal frontal lobe epilepsy as a potentially fruitful paradigm for advancing seizure prediction. Narrowing the inescapable cultural chasm that commonly fragments multidisciplinary efforts, this book captures and enriches the burgeoning interdisciplinary synergism in the nascent field of dynamical epileptology. Catalog no. K11766, April 2011, 546 pp. ISBN: 978-1-4398-3885-3, $189.95 / £121.00

Epileptic Seizures and the EEG Measurement, Models, Detection and Prediction Andrea Varsavsky and Iven Mareels The University of Melbourne, Australia

Mark Cook St. Vincent's Hospital and the University of Melbourne, Victoria, Australia

The book focuses on the problem of seizure detection and surveys the physiologically based dynamic models of brain activity. Finally, the book addresses the fundamental question: can seizures be predicted? Through analysis of epileptic activity spanning from 3 hours to 25 years, it is proposed that seizures may be predictable, but the amount of data required is greater than previously thought. Based on the authors’ extensive research, exploring the current research and future possibilities in seizure prediction.

Features: • Assembles information gathered from and varied sources • Explains epilepsy from an interdisciplinary perspective • Evaluates the feasibility of seizure prediction • Challenges preconceptions concerning the analysis of the signals generated by the epileptic brain The book begins by summarizing the physiology and the fundamental ideas behind the measurement, analysis and modeling of the epileptic brain. It introduces the EEG as a measured signal and explains its use in the study of epilepsy. Next, it provides an explanation of the type of brain activity likely to register in EEG measurements, offering quantitative analysis of the populations of neurons that contribute to both scalp and cortical EEG and discussing the limitations and effects that choices made in the recording process have on the data. The book provides an overview of how these EEG records are and have been analyzed in the past, concentrating on the mathematics relevant to the problem of classification of EEG. The authors use these extracted features to differentiate between or classify interseizure, pre-seizure and seizure EEG. Catalog no. K10604, January 2011, 370 pp. ISBN: 978-1-4398-1200-6, $139.95 / £89.00 Also available as an eBook

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Drug Discovery & Delivery Automated EEG-Based Diagnosis of Neurological Disorders Inventing the Future of Neurology Hojjat Adeli Ohio State University, Columbus, USA

Samanwoy Ghosh-Dastidar Ardmore, Pennsylvania, USA

Based on the authors’ groundbreaking research, Automated EEG-Based Diagnosis of Neurological Disorders: Inventing the Future of Neurology presents a research ideology, a novel multi-paradigm methodology, and advanced computational models for the automated EEG-based diagnosis of neurological disorders. It is based on the ingenious integration of three different computing technologies and problemsolving paradigms: neural networks, wavelets, and chaos theory. The book also includes three introductory chapters that familiarize readers with these three distinct paradigms.

Neuroengineering Edited by

Daniel J. DiLorenzo, MD, Ph.D., MBA DiLorenzo Biomedical, LLC, Houston, Texas, USA

Joseph D. Bronzino, Ph.D. Trinity College, Hartford, Connecticut, USA

The book presents clinical applications of neuromodulation and a detailed review of the science and mechanisms of action underlying deep brain stimulation. Contributions include discussions of seizure control, clinical, surgical, and technological aspects of responsive neurostimulation, and a thorough review of spinal cord stimulation for pain control. The book highlights promising technologies and applications for neural augmentation, brain and computer interfaces, and motor prostheses. It concludes with coverage of the science underlying neurostimulation techniques and paradigm-shifting neuromodulation technologies.

Features:

Introduction and Basic Concepts. Automated EEG-Based Diagnosis of Epilepsy. Automated EEG-Based Diagnosis of the Alzheimer's Disease. The Next Generation of Neural Networks: Spiking Neural Networks.

• Examines the fundamental science underlying neural modulation and relevant neurophysiology • Offers detailed descriptions of BrainGate, the Cone electrode, ParaStep®, and the BION® • Includes over 150 figures that allow you to visualize anatomy, technologies, and surgical procedures • Provides broad coverage of technologies, clinical fields, and markets • Focuses on high-impact technologies with contributions from established and accepted leaders We are on the cusp of a technological revolution that promises to have more of an impact on human health, disease, and quality of life than any other in recent history. Its impact on medicine and society promises to be as dramatic as that of the development of antibiotics. The transition of neural engineering from basic research to intense commercialization and widespread clinical application and acceptance is just around the corner. Providing in-depth coverage of developments in technology and clinical practice, the book presents detailed descriptions of technologies, science, and clinical results that build a foundation for the future.

Catalog no. K10784, 2010, 423 pp. ISBN: 978-1-4398-1531-1, $159.95 / £99.00 Also available as an eBook

Catalog no. 8174, 2008, 408 pp. ISBN: 978-0-8493-8174-4, $99.95 / £63.99 Also available as an eBook

Features: • Presents a novel approach for automated EEG-based diagnosis of neurological disorders such as epilepsy and Alzheimer's disease • Explains the authors' methodology, which is shown to diagnose epilepsy and detect seizures with a high accuracy rate of 96% • Provides three introductory chapters on the three different computing paradigms used • Contains numerous illustrations, tables, and step-by-step algorithms The methodology presented in the book is especially versatile and can be adapted and applied for the diagnosis of other brain disorders. The senior author is currently extending the new technology to diagnosis of ADHD and autism. A second contribution made by the book is its presentation and advancement of Spiking Neural Networks as the seminal foundation of a more realistic and plausible third generation neural network.

Selected Contents:

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Bioprocessing

The Metabolic Pathway Engineering Handbook, Two-Volume Set Christina D. Smolke Stanford University, California, USA

Christina Smolke, who recently developed a novel way to churn out large quantities of drugs from genetically modified brewer’s yeast, is regarded as one of the most brilliant new minds in biomedical engineering. In this handbook, she brings together pioneering scientists from dozens of disciplines to provide a complete record of accomplishment in metabolic pathway engineering. With a wealth of cutting-edge material, this work is an invaluable resource for those seeking to add their own contributions. Organized by topic, this reference is available as two volumes that can be purchased individually or as a set.

Features: • Presents a thorough and complete overview of the burgeoning field of metabolic pathway engineering • Focuses on the future areas of metabolic engineering and the impact of new technologies • Contains extensive references in each chapter • Features contributions from well-established experts in various subfields of metabolic engineering

Buy the Set and Save! Catalog no. 3923, 2010, 1259 pp., ISBN: 978-0-8493-3923-3, $257.95 / £164.00

Volume I: Fundamentals

Volume II: Tool and Applications

The first volume provides an overview of metabolic pathway engineering with a look towards the future. It discusses cellular metabolism, including transport processes inside the cell and energy generating reactions, as well as rare metabolic conversions. This volume also explores balances and reaction models, the regulation of metabolic pathways, and genome scale and multiscale modeling tools. It also covers developing appropriate hosts for metabolic engineering including the use of Escherichia coli, yeast, Bacillus subtilis, Streptomyces, filamentous fungi, and mammalian cells using cell culture.

The second volume delves into evolutionary tools, including those associated with gene expression for metabolic pathway engineering. It covers applications of emerging technologies, including research on genome-wide technologies, DNA and phenotypic microarrays, and proteomics tools for experimentally determining flux through pathways. It also evaluates emerging applications for producing fine chemicals, drugs, and alternative fuels.

Selected Contents: Introduction and Preface to Handbook. Cellular Metabolism. Balances and Reaction Models. Regulation of Metabolic Pathways. Modeling Tools for Metabolic Engineering. Developing Appropriate Hosts for Metabolic Engineering. Catalog no. K10164, 2010, 678 pp. ISBN: 978-1-4398-0296-0, $164.95 / £102.00

Selected Contents: Evolutionary Tools in Metabolic Engineering. Gene Expression Tools for Metabolic Pathway Engineering. Applications of Emerging Technologies to Metabolic Engineering. Future Prospects in Metabolic Engineering. Appendix I: Tools for Experimentally Determining Flux through Pathways. Appendix II: Applications. Catalog no. 77651, 2010, 581 pp. ISBN: 978-1-4200-7765-0, $164.95 / £102.00 Also available as an eBook

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Bioprocessing Macroporous Polymers Production Properties and Biotechnological /Biomedical Applications Edited by

Second Edition Joel Plawsky Rensselaer Polytechnic Institute, Troy, New York, USA Series: Chemical Industries

Bo Mattiasson and Igor Yu. Galeaev Lund University, Sweden

Ashok Kumar Indian Institute of Technology, Kampur, India

Macroporous polymers are rapidly becoming the material of choice for many tissue engineering, bioseparation, and bioprocessing applications. Presented in a systematic way, this book addresses the production, characterization, and application of these polymers. The text considers traditional methods of production, including phase separation polymerization, leaching, foaming, and double emulsion, as well as emerging methods such as cryogelation. The chapters also detail the various applications of macroporous gels for the separation of biomolecules and for the cultivation of mammalian cells in bioreactors, as well as for tissue engineering.

Features: • Includes almost two hundred black and white illustrations, thirty tables, and a four-page color insert • Summarizes recent research on preparation of macroporous cryogels via free-radical polymerization and points to some future perspectives • Describes different leaching techniques that have been used to fabricate porous polymer solids for biomedical applications • Provides an overview of the techniques used for the characterization of porous hydrogels by describing the potential of each particular method and its limitations • Discusses the polymerization of polyesters by ring opening polymerization, scaffold fabrication techniques, surface modification of polyester scaffolds to improve cell culture properties, and selection of a suitable bioreactor for a given scaffold

Selected Contents: Macroporous Gels. Characterization of Macroporous Gels. Fundamentals of Growing Mammalian Cells in 3D Cultures. Catalog no. 84615, 2010, 525 pp. ISBN: 978-1-4200-8461-0, $133.95 / £85.00 Also available as an eBook

Transport Phenomena Fundamentals

One of the foundations of chemical engineering is built upon transport phenomena. This text provides a unified treatment of heat, mass, and momentum transport based on a balance equation approach. The first part of the book takes readers through the balance equation in the context of diffusive transport. The second half builds upon the balance equation description of diffusive transport by introducing convective transport terms, focusing on partial rather than ordinary differential equations. A series of example modules are provided online on the author’s website, which is designed to be a living component of the course.

Features: • Presents a unified, holistic approach to transport processes • Uses finite element methods as a tool for enhanced understanding • Teaches readers to analyze computer-based solutions to check for validity • Incorporates momentum, heat, mass, and charge transport • Explains the mathematics behind the description of the phenomena and the development of the equations Solutions manual is available with qualifying course adoption

Selected Contents Introductory Concepts. Fluxes, Gradients, and Transport Properties. Transport Properties of Materials. One-Dimensional, Steady-State, Diffusive Transport. Generation. Accumulation. Conservative Transport and WavesTransport Enhancement Using Extended Surfaces. Multidimensional Effects, Potential Functions, and Fields. Convective Transport – Microscopic Balances. Macroscopic/Engineering Balances. Convective Transport on a Flat Plate. Convective Transport: Systems with Curvature. Turbulent Boundary Layers. Radiative Transport. Nomenclature. Appendices. Index. Catalog no. 62336, 2010, 857 pp. ISBN: 978-1-4200-6233-5, $129.95 / £49.99 Also available as an eBook

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Biomaterials & Medical Devices

New!

Biological and Biomedical Coatings Handbook Two-Volume Set Edited by

Sam Zhang Nanyang Technological University, Singapore Series: Advances in Materials Science and Engineering

Providing a timely reference for both experts and newcomers, this two-volume handbook explores the latest developments in films and coatings for biological and biomedical applications. It covers a wide array of material types, including sol-gel, bio-ceramics, polymers, glass, nanomaterials, and chitosan. It also addresses various processes for developing and implementing these coatings, including CVD and PVD, drug delivery, released-control coatings, and spectroscopy.

Features: • • • •

Covers processing, properties, and performance Discusses sol-gels, bio-ceramics, polymers, glasses, nanomaterials, and other materials Covers CVD and PVD Includes information on drug delivery and released-control coatings

Buy the Set and Save! Catalog no. K11126, April 2011, 976 pp., ISBN: 978-1-4398-2125-1, $249.95 / £159.00

Volume I: Applications Selected Contents: Sol–Gel Derived Hydroxyapatite Coatings on Metallic Implants: Characterization, In Vitro and In Vivo Analysis. Amorphous Carbon Coatings for Biological Applications. Biomedical Applications of Carbon-Based Materials. Impedance Spectroscopy on Carbon-Based Materials for Biological Application. Control of Drug Release from Coatings: Theories and Methodologies. Release-Controlled Coatings. Orthopedic and Dental Implant Surfaces and Coatings. Piezoelectric Zinc Oxide and Aluminum Nitride Films for Microfluidic and Biosensing Applications. Medical Applications of SputterDeposited Shape Memory Alloy Thin Films. Bioactive Coatings for Implanted Devices. Index. Catalog no. K12270, April 2011, 520 pp. ISBN: 978-1-4398-4996-5, $139.95 / £89.00

Volume II: Processing and Characterization Selected Contents: Bonelike Mineral and Organically Modified Bonelike Mineral Coatings. Synthesis and Characterization of Hydroxyapatite Nanocoatings by Sol–Gel Method for Clinical Applications. Hydroxyapatite and Other Biomedical Coatings by Electrophoretic Deposition. Thermal Sprayed Bioceramic Coatings: Nanostructured Hydroxyapatite (HA) and HA-Based Composites. Nanostructured Titania Coatings for Biological Applications: Fabrication and Characterization. Hydrothermal Crystallization with Microstructural Self-Healing Effect on Mechanical and Failure Behaviors of PlasmaSprayed Hydroxyapatite Coatings. Bioceramic Coating on Titanium by Physical and Chemical Vapor Deposition. Coating of Material Surfaces with Layer-by- Layer Assembled Polyelectrolyte Films. Bioactive Glass-Based Coatings and Modified Surfaces: Strategies for the Manufacture, Testing, and Clinical Applications for Regenerative Medicine. Index. Catalog no. K12269, April 2011, 456 pp. ISBN: 978-1-4398-4995-8, $139.95 / £89.00

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Biomaterials & Medical Devices Tissue Engineering John P. Fisher University of Maryland, College Park, USA

Biomaterials

Antonios G. Mikos

Joyce Y. Wong

Rice University, Houston, Texas, USA

Boston University, Massachusetts, USA

Joseph D. Bronzino

Trinity College, Hartford, Connecticut, USA

The ability to engineer biocompatible tissue is the hallmark of modern biomedical engineering, integrating all aspects of every sub-discipline in the field. Contributed by a diverse group of international contributors with backgrounds in academia, clinical medicine, and industry, this volume surveys advances in this relatively young area. Divided into three sections, it discusses the fundamental concepts of tissue engineering, enabling technologies, and tissue engineering applications. It examines strategies that incorporate scaffolds, nanocomposites, bioreactors, drug delivery systems, and gene therapy techniques that are being applied in regenerative medicine.

For medical devices that must be placed inside the body, the right choice of material is a vital aspect of design. In chapters drawn from the third edition of the best-selling Biomedical Engineering Handbook, this text surveys the wide variety of biomaterials in use as well as materials resulting from micro- and nanoscale technologies. In addition to material from the Handbook, nearly one-third of this sharply focused work is new. Catalog no. 7888, 2007, 296 pp. ISBN: 978-0-8493-7888-1, $99.95 / £63.99 Also available as an eBook

Catalog no. 9026, 2007, 600 pp. ISBN: 978-0-8493-9026-5, $99.95 / £63.99 Also available as an eBook

Biomaterials Fabrication and Processing Handbook

Ultrasonics Data, Equations and Their Practical Uses

Edited by

Paul K. Chu

Dale Ensminger

City University of Hong Kong, Kowloon, China

Sunnyvale, California, USA

Xuanyong Liu Shanghai Institute of Ceramics, China

Ethicon Endo-Surgery, Cincinnati, Ohio, USA

This volume focuses on a variety of production and processing aspects of the latest biomaterials. It discusses how scaffolds are used in tissue engineering and describes common implant materials. The book also examines the important role nanotechnology plays in the preparation of drugs, protein delivery, tissue engineering, cardiovascular biomaterials, hard tissue replacements, biosensors, and bio-MEMS. With contributions from renowned international experts, this book provides detailed, practical information on producing and employing biomaterials.

This volume provides data and functions gathered from several areas of science and technology. To facilitate the use of ultrasonic energy, this book evaluates the practicality of new ideas and explores how to make important data available for the design of ultrasonic systems to meet recent developments, such as applications in standard and harsh environments. Additional coverage includes design equations, piezoelectric materials, magnetostrictive transducer design data, materials evaluation, and mechanical effects of ultrasonic energy.

Catalog no. 7973, 2008, 720 pp. ISBN: 978-0-8493-7973-4, $162.95 / £102.00 Also available as an eBook

Catalog no. DK8307, 2009, 508 pp. ISBN: 978-0-8247-5830-1, $149.95 / £96.00 Also available as an eBook

Foster B. Stulen

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Biomaterials & Medical Devices Usability Testing of Medical Devices Michael Wiklund, Jonathan Kendler, and Allison Yale Strochlic Wiklund Research Design, Concord, Massachusetts, USA

Informative, practical, and engaging, this handbook covers how to conduct usability tests of medical devices. Recognizing that the intended readers are busy and disinclined to read lengthy textbooks, this book has been carefully designed to be concise and visual, allowing readers to jump from one section to another as needed. It provides a general understanding of usability testing and reviews key concepts. It highlights the challenges of validating that protects against dangerous errors that could lead to patient injury and death.

Features: • Provides a singular source of guidance on conducting a usability test in an industryspecific manner, as opposed to a manner better suited to evaluating consumer, and business products, that pose different demands • Presents the information in a highly visual format, making it appealing to the audience comprised mostly marketers, engineers, and regulatory affairs specialists • Draws on the experience of the author, a widely recognized authority in the medical industry on usability testing of medical devices • Includes an accompanying CD-ROM that contains videos of mock usability tests • Supplies sample test plans for practitioners who would prefer to "plug" content into an authoritative template

Selected Contents: Introduction. Risk Management and Usability Testing. The Commercial Imperative. Testing Costs. Anatomy of a Usability Test. Types of Tests. Writing a Test Plan. Choosing a Participant Sample and Recruiting Participants. Test Environments. Adding Realism. Selecting Tasks. Conducting the Test. Interacting with Test Participants. Documenting the Test. Analyzing Test Data. Reporting Results. Validation Testing. Resources. Index. Catalog no. K10595, January 2011, 412 pp. ISBN: 978-1-4398-1183-2, $69.95 / £44.99 Also available as an eBook

A Laboratory Course in Biomaterials Wujing Xian University of Illinois at UrbanaChampaign, USA

A teaching tool for instructors in biomaterials and bioengineering, this volume is a comprehensive laboratory textbook. It trains readers in laboratory skills, data analysis, problem solving, and scientific writing and integrates a variety of principles that include materials science, chemistry, biochemistry, molecular and cell biology, and engineering. Providing detailed descriptions, explanations, and illustrations of experiments, the text also includes a series of questions and answers at the end of each chapter to clarify concepts. Many of the experiments presented are adapted from research papers to reflect the recent progress in biomaterials and bioengineering.

Features: • Contains user-friendly graphic illustrations or the experiments • Provides a series of questions and answers at the end of each chapter to clarify concepts and induce critical thinking • Includes text boxes with in-depth information, case studies, and lab tips • Offers information on equipment, reagents, and supplies for instructors

Selected Contents: Basic Laboratory Skills: Drug Delivery: Controlled Release of Encapsulated Protein from PLGA Microspheres: Natural Biomaterials: Collagen and Chitosan. Basic Laboratory Skills II. Cell Culture and Microscopy. Biocompatibility Testing: Cytotoxicity and Adhesion. Tissue Engineering: Organotypic Cultures of Skin Equivalents. Bioceramics: Porous Hydroxyapatite Composite. Appendix: Answers. Index. Catalog no. 75829, 2009, 216 pp., Soft Cover ISBN: 978-1-4200-7582-3, $61.95 / £39.99 Also available as an eBook

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Biomaterials & Medical Devices

Porous Media Applications in Biological Systems and Biotechnology

Nanobiotechnology Nanotechnology and Tissue Engineering The Scaffold Edited by

Edited by

Cato T. Laurencin

Kambiz Vafai

University of Virginia, Charlottesville, USA

University of California, Riverside, USA

Lakshmi S. Nair

Presenting state-of-the-art research advancements, this volume explores innovative approaches to effectively apply existing porous media technologies to biomedical applications. In each peerreviewed chapter, world-class scientists and engineers address significant problems and discuss exciting research in biological systems. They cover various transport processes, mechanical behavior, and material properties of biological tissues from a porous media point of view. The book also presents pertinent aspects of experimental work and numerical techniques and discusses the modeling of several phenomena, including flow changes in cerebral aneurysms, biomass growth, marine systems, and tissue homeostasis and repair. Catalog no. 65416, January 2011, 632 pp., ISBN: 978-1-4200-6541-1, $149.95 / £95.00 Also available as an eBook

University of Connecticut, Farmington, USA

This resource brings together research and background information on a complete range of engineering processes that have led to the development of a number of highly useful tissues. It details the fundamental and advanced aspects of nanofabrication and includes an examination of cellular interactions at the nanoscale level. This highly comprehensive resource also discusses clinical implications and applications, making it a work of importance for clinicians and an essential reference for engineers and other scientists seeking to further advance the field. Catalog no. 51822, 2008, 384 pp. ISBN: 978-1-4200-5182-7, $162.95 / £102.00 Also available as an eBook

Coming Soon!

Chitosan-Based Hydrogels Functions and Applications

Methods, Devices, and Applications

Edited by

Kangde Yao, Junjie Li, Fanglian Yao, and Yuji Yin Tianjin University, China

Chitosan is a natural biopolymer obtained through the deacetylation of chitin, which is derived from marine shellfish and other biological sources. Providing a theoretical basis for the design of biomaterials, this book discusses the relationship between the structure and functions of chitosan-based hydrogels. It covers many research fields, including materials science, biotechnology, pharmaceutics, regenerative medicine, and cell engineering. The author also presents numerous real-world examples that illustrate the vast array of potential applications for chitosan-based hydrogels. This includes its use as a carrier in drug delivery/release and in the scaffolds of tissue engineering. Catalog no. K11120, July 2011, c. 506 pp. ISBN: 978-1-4398-2114-5, $189.95 / £121.00

Nanotechnology in Biology and Medicine Edited by

Tuan Vo-Dinh Duke University, Durham, North Carolina, USA

Nanodevices enable scientists to more accurately detect, analyze, and manipulate nanostructures at the molecular level. With emphasis on the application and design of nanomaterials, devices, and sensors, this book carefully details methods, protocols, and instrumentation for biomedical applications including stem cell research, gene diagnostics, targeted drug delivery, and tissue engineering. Pioneers in the field offer a cohesive compilation of data, practical tool kits, references, and experimental insight on relevant topics including self-assembly, bioinspired materials, and biomanufacturing. Catalog no. 2949, 2007, 792 pp. ISBN: 978-0-8493-2949-4, $167.95 / £107.00 Also available as an eBook

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Nanobiotechnology Nanotechnology Understanding Small Systems, Second Edition Reno, Nevada, USA

Nanobiomaterials Handbook

Sumita Pennathur

Edited by

University of California, Santa Barbara, USA

Balaji Sitharaman

Ben Rogers

State University of New York at Stony Brook, USA

Jesse Adams Nevada Nano, Inc., Reno, USA The CRC Press Series in Mechanical and Aerospace Engineering

Praise for the First Edition “… It is written in an easily understandable manner, not requiring from the reader deep knowledge in the related topics of physics and mathematics before reading this book. It uncovers the most important things about nanotechnology explained in a very illustrative manner with many simple examples, figures, and ‘backof-the-envelope’ calculations, so that the reader can get a good feeling for the numbers of nanotechnology. …” —Zentralblatt MATH, 1185

With substantial revisions, additional material, and extensive updates, this second edition of one of the primary works on the subject of nanotechnology incorporates user input and the perceived need to deliver a significant contribution to the current body of knowledge. New to this edition is an expanded glossary of over 300 terms enabling the text to be used as an effective nanotech dictionary. Each chapter includes updates and additional references while retaining the successful format of the original. Revisions and amendments extend to the solutions manual and other ancillary materials, making this text the gold standard in nanotechnology.

Selected Contents: Big Picture and Principles of the Small World. Introduction to Miniaturization. Introduction to Nanoscale Physics. Nanomaterials. Nanomechanics. Nanoelectronics. Nanoscale Heat Transfer. Nanophotonics. Nanoscale Fluid Mechanics. Nanobiotechnology. Index. Catalog no. K12225, June 2011, 400 pp. ISBN: 978-1-4398-4920-0, $99.95 / £63.99

A comprehensive overview of and broad introduction to the field of nanobiomaterials, this handbook defines the field and discusses its scope, current status, and future prospects. It then provides an in-depth survey of nanobiomaterials and provides a comprehensive overview of the various synthesis and processing techniques important for developing bionanomaterials. It also includes a detailed overview of the interaction between bionanomaterials/biological systems and the biocompatibility issues associated with bionanomaterials. Extensive references are included at the end of each chapter to enhance additional study.

Selected Contents: Nanobiomaterials. Synthesis, Processing, and Characterization of Ceramic Nanobiomaterials for Biomedical Applications. Synthesis, Properties, Characterization, and Processing of Polymeric Nanobiomaterials for Biomedical Applications. Carbon-Based Nanomedicine. Synthetic and Toxicological Characteristics of Silica Nanomaterials for Imaging and Drug Delivery Applications. Peptide-Based SelfAssembled Nanofibers for Biomedical Applications. Electrostatically Self-Assembled Nanomaterials. Peptide-Based Nanomaterials for siRNA Delivery. Nucleic Acid Nanobiomaterials. Emerging Technologies in Nanomedicine. Nanomaterials for Therapeutic Drug Delivery. Nanobiomaterials for Nonviral Gene Delivery. Nanobiomaterials for CancerTargeting Therapy. Nanobiomaterials for Ocular Applications. Nucleic Acid Based Nanobiosensing. Nanobiomaterials for Molecular Imaging. Gadolinium-Based Bionanomaterials for Magnetic Resonance Imaging. Nanostructured Materials for Improved Magnetic Resonance Imaging. Nanobiomaterials for Dual-Mode Molecular Imaging. Nanoscale Probes for the Imaging of RNA in Living Cells. Catalog no. 94661, June 2011, 840 pp. ISBN: 978-1-4200-9466-4, $169.95 / £108.00

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Nanobiotechnology Coming Soon!

Bionanotechnology II Global Prospects

Nano- and Biocomposites

Edited by

David E. Reisner

Alan Kin-tak Lau, Farzana Hussain, and Khalid Lafdi

The Nano Group, Inc., Farmington, Connecticut, USA

This book covers the biological processes and structures being used to develop technologies that can improve medicine and agriculture. Topics include: self-assembly, cell detection strategies, and medical diagnostics, labeling, and imaging, as well as development of antiviral therapeutics, drug delivery, tissue engineering, and theragnostic nanoparticles that can diagnose, treat, and monitor diseases. Discussing the formation of crucial one-dimensional nanostructures that can lead to advances such as development of novel nanowires and other devices, this book navigates our newfound ability to insinuate our own design skills at the nanoscale level in living systems. Catalog no. K10254, July 2011, c. 559 pp. ISBN: 978-1-4398-0463-6, $99.95 / £63.99

Nanotechnology in Tissue Engineering and Regenerative Medicine Edited by

Catalog no. 8027X, 2010, 408 pp. ISBN: 978-1-4200-8027-8, $164.95 / £102.00 Also available as an eBook

Medical Nanotechnology and Nanomedicine Harry F. Tibbals University of Texas Southwestern Medical Center, Dallas, USA Series: Perspectives in Nanotechnology

Ketul Popat Referred to as "nanomedicine" or "nanobiomedicine," the application of nanotechnology to medicine can impact diagnosis, monitoring, and treatment of diseases, as well as the control and understanding of biological systems. Bringing together an unparalleled field of experts, this volume explores various aspects of nanotechnology and its applications in biomedical fields. The book uses an application-oriented approach to relate laboratory-based research to the development of technologies that can be readily adaptable to an industrial environment, focusing chiefly on drug delivery, tissue engineering, and regenerative medicine. Catalog no. K10090, January 2011, 302 pp. ISBN: 978-1-4398-0141-3, $119.95 / £72.00 Also available as an eBook

This forward-thinking book is one of the first to meld research in biocomposites with advances in nanocomposite technology, to provide an interdisciplinary resource on advanced materials for the biomedical industry. It brings together pioneering researchers who describe their contributions to the field. Among other areas, they cover nanostructured polymer composites and nano/bio composites. They look at developments in tissue engineering, safer resins for tooth and bone repair, and improved artificial joints. They also discuss potential opportunities for continued research in this well-funded field.

This accessible guide reviews advances in nanoscience and nanotechnology and considers their applications in medicine. Providing an introduction to both the science and the infrastructure required to support these advances, this volume is written for non-experts, which can include medical researchers and clinicians, as well as those concerned with business aspects, regulation, and the administration of medical practices. The book provides a contextual background including history, definitions, and recent trends, and then investigates current and future nanotech applications in medicine and the biomedical sciences. Catalog no. K10431, January 2011, 527 pp. Soft Cover, ISBN: 978-1-4398-0874-0 $69.95 / £44.99 Also available as an eBook

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A Simplified Guide to One of the Hottest Topics in Biomaterials & Devices

Catalog no. K11126 April 2011 976 pp., ISBN: 978-1-4398-2125-1 $249.95 / ÂŁ159.00

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