e
Se
’re ou
ty ha
w
si is
m
. ng
s W ffer NO ail o com UP E em ess. GN IV pr SI CLUS .crc X ww rE w fo at
Biophysics
Introduction to Experimental Biophysics Biological Methods for Physical Scientists Jay Nadeau McGill University, Montreal, Quebec, Canada
“The book provides a comprehensive overview of diverse methods in biophysics. It will be a great resource for every working scientist in the physical sciences. It would also be a great supporting text to read as part of an introductory course in biophysical methods, particularly for graduate students and postdocs entering the field from other disciplines.” —Anthony J. Koleske, Yale University
“…a useful tool to undergraduate and graduate students and a valuable reference for researchers in the field.” —Françisco M. Raymo, University of Miami
“This book fills the need for a practical, hands-on guide for physical scientists who are moving into biological research.” —Daniel A. Beard, Medical College of Wisconsin
“This book will be appropriate for any experimentalist in chemistry or physics who is moving into biological work. It will also be excellent reading material for undergraduate or graduate students who will be working in a biologically oriented lab, as well as for an advanced lab class in biophysics or bioengineering.” —Mark C. Williams, Northeastern University
“The author has made a great effort to keep everything defined and simple.” —James A. Forrest, University of Waterloo
A practical companion for physical scientists investigating wet laboratory experiments and biological research areas, this book gives a clear understanding of what is experimentally feasible. Introducing basic terminology and concepts, the text begins with simple, fundamental methods and builds gradually to more advanced techniques. Addressing genes, proteins, and expression systems, the author employs a straightforward approach, allowing readers to follow the process involved in the production of nucleic acids and proteins and the different levels of purification required for each type of analysis. • Provides a thorough description of modern experimental and analytical techniques used in biological and biophysical research • Includes practical information and step-by-step guidance on instrumentation and experimental design • Offers recipes for common solutions and media, lists of important reagents, and a glossary of biological terms used
Selected Contents: Introduction and Background. Molecular Cloning of DNA and RNA. Expression of Genes in Bacteria, Yeast, and Cultured Mammalian Cells. Protein Expression Methods. Protein Crystallization. Introduction to Biological Light Microscopy. Quantitative Cell Culture Techniques. Semiconductor Nanoparticles (Quantum Dots). Gold Nanoparticles. Surface Functionalization Techniques. Electrophysiology. Spectroscopy Tools and Techniques. Appendix. Glossary. Index.
Catalog no. K11452, September 2011, 672 pp., Soft Cover, ISBN: 978-1-4398-2953-0, $89.95 / £57.99 Also available as an eBook
2
Save when you order online at www.crcpress.com
Biophysics Coming soon!
Quantitative Biology From Molecular to Cellular Systems Edited by
Michael E. Wall Los Alamos National Laboratory, New Mexico, USA
Providing an overview of quantitative biology, this book presents practical tools for the observation, modeling, design, and manipulation of biosystems from the molecular to cellular levels. Each chapter offers an introduction to fundamental concepts and computational, mathematical, and experimental studies of molecular and cellular behavior. The first section of the text covers basic, integrative concepts that form the foundation of the field. The next section reviews state-of-the-art methods in quantitative biology and case studies of specific systems. The last section focuses on important biological systems where modern quantitative biology methods are making an impact. • Provides an introductory overview of the field with emphasis on fundamental theory and methodology • Illustrates how quantitative methods are applied to increase our understanding of biological systems at the molecular and cellular levels • Covers a broad spectrum of quantitative approaches, including single molecule biochemistry, single cell behavior, and modeling cell-to-cell variations • Includes detailed descriptions of important examples, from transcription to cell signaling and chemotaxis
Contents: Preface, Michael E. Wall Fundamental Concepts Free Energies, Landscapes and Fitness in Evolution Dynamics, Robert H. Austin System Design Principles, Michael A. Savageau Chance and Memory, Theodore J. Perkins, Andrea Y. Weiße, and Peter S. Swain Information Theory and Adaptation, Ilya Nemenman Quantitative Methods Quantitative in vitro Biochemistry, One Molecule at a Time, Jeffrey A. Hanson and Haw Yang Small-Angle Scattering: For Structural Molecular Biologists, Cy Jeffries and Jill Trewhella Subcellular Signaling Dynamics, Jeffrey J. Saucerman and Jin Zhang Single-Cell Behavior, Philippe Cluzel Biophysical Models to Predict the Functions of Common Genetic Parts Used in Synthetic Biology, Ying-Ja Chen and Christopher A. Voigt Modeling Cellular Variability, Brian Munsky Molecular and Cellular Systems PKA: Prototype for Dynamic Signaling in Time and Space, Susan S. Taylor and Alexandr P. Kornev Stochastic Simulation of the Phage Lambda Gene Regulatory Circuitry, John W. Little and Adam P. Arkin Chemotaxis, Howard C. Berg
Catalog no. K11344, August 2012, c. 440 pp., ISBN: 978-1-4398-2722-2, $89.95 / £57.99
Also available
Engineering Genetic Circuits Chris J. Myers University of Utah, Salt Lake City, USA
Catalog no. C3244, July 2009, 306 pp., ISBN: 978-1-4200-8324-8 $75.95 / £47.99
For more information and complete contents, visit www.crcpress.com
3
Biophysics
New!
Handbook of Lipid Bilayers Second Edition Derek Marsh Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany
This handbook provides the only single source for primary physicochemical data relating to phospholipid bilayers. Coverage includes both dynamic and structural properties of phospholipid bilayers, along with basic thermodynamic data. With 50 percent more data, this second edition contains new sections on phase diagrams with cholesterol, hydration isotherms, spontaneous curvature, and cubic phases. It also presents expanded information on glycolipids and includes more detailed introductory sections that explain important concepts and provide a broader framework for understanding the data.
New to the Second Edition • Chapters on crystal structures of phospholipids include new structures and more comprehensive data on bond lengths, bond angles, and torsion angles—and all coordinates are Cartesian. • Wide-angle data is indexed whenever possible to characterize chain-packing modes in gel and crystalline lamellar phases. • Low-angle data are analyzed in terms of the lipid and water thicknesses. • Headgroup separations in electron density profiles for phospholipids are included, with a separate section devoted to the in-depth analysis of electron density profiles that provides the most detailed structural information on fluid lamellar phases. • Phase diagrams of phospholipid mixtures are vastly expanded and have been redrawn in standardized format to aid intercomparison. Cholesterol, including ternary systems, is now featured. • New sections on titration calorimetry and extended data on the temperature dependence of transfer rate. • The greatly expanded chapter on bilayer–bilayer interactions features new and detailed information on the components of interbilayer pressure.
Selected Contents: INTRODUCTION: Lipid Classification. Nomenclature of Lipids. Fatty Acids. PHOSPHOLIPIDS: Phospholipid Classification and Molecular Weights. Fatty Acid Composition of Naturally Occurring Phospholipids and of Membrane Lipids from the Yeast Lipidome. Physicochemical Properties of Phospholipids. Phospholipid pKas. Crystal Structures of Phospholipids. Phase Behavior and Hydration. Calorimetric Data. X-Ray Diffraction Data. Densitometric Data. Elastic Constants. Dynamic Properties. Phase Transition Temperatures. Phase Diagrams: Binary and Ternary Mixtures. Non-Lamellar Phases (Hexagonal and Cubic). Critical Micelle Concentrations and Lipid Transfer. Bilayer-Bilayer Interactions. Ion-Binding Constants. GLYCOLIPIDS: Glycolipid Classification and Molecular Weights. Fatty Acid Composition of Naturally Occurring Glycolipids. Physicochemical Properties of Glycolipids. Glycolipid pKas. Crystal Structures. Phase Behavior and Hydration. Calorimetric Data. X-Ray Diffraction Data. Densitometric Data. Elastic Constants. Dynamic Properties. Phase Transition Temperatures. Phase Diagrams: Binary Mixtures. Non-Lamellar Phases (Hexagonal and Cubic). Critical Micelle Concentrations and Lipid Transfer. Bilayer-Bilayer Interactions. Ion-Binding Constants.
Catalog no. 88327, May 2012, 1130 pp., ISBN: 978-1-4200-8832-8, $249.95 / £159.00 Also available as an eBook
4
Save when you order online at www.crcpress.com
Biophysics
The Structure of Biological Membranes Third Edition Edited by
Philip L. Yeagle Rutgers University, Newark, New Jersey, USA
Praise for Previous Editions: “Among the seemingly limitless universe of specialist/specialized monographs in biochemistry, this one clearly stands out. The overall verdict must be: very recommendable to anyone wishing to go beyond the biochemistry/cell biology textbook. A good, practical purchase for every laboratory library.” —Cell Biochemistry and Function, July-August 2005
“I am confident that this book will be useful for students of chemical, biological, and bioorganic faculties of universities, and also to a wide audience of biochemists, molecular and cell biologists, and biotechnologists.” —G. Ya. Wiederschain, Shire Pharmaceuticals, Inc.
Completely revised and updated to reflect advances in the study of biological membranes, this third edition provides an integrated view of membrane structure and function. New introductory chapters focus on the fundamentals of lipid bilayers and membrane proteins for those new to the field. The second part of the book presents in-depth, up-to-date analyses of current topics, including the phase behavior of lipid bilayers; cholesterol’s role in cell biology; the lateral organization of membranes; the role of lipids in membrane protein folding; membrane protein synthesis, stability, and transport; and interactions between proteins and lipids. It offers a valuable resource for researchers and students alike. • Provides a fundamental framework for understanding membrane structure and structure-function relationships • Presents selected state-of-the-art reviews on current topics in membrane structure research • Pairs introductory-level material for those new to the field with current topics for researchers in the field • Includes extensive references for further reading
Selected Contents: Introduction to Lipid Bilayers. Membrane Proteins. Introduction to Lipid–Protein Interactions in Biological Membranes. The Mesomorphic Phase Behavior of Lipid Bilayers. IR Spectroscopy of Lipid Chains: Theoretical Background and Applications to Phase Transitions, Membranes, Cells, and Tissues. The Roles of Cholesterol in the Biology of Cells. Functional Consequences of the Lateral Organization of Biological Membranes. Mechanisms by Which Pathogens Hijack and Utilize Membrane Domains to Mediate Cytotoxicity. Lipid-Assisted Membrane Protein Folding and Topogenesis. Membrane Protein Biogenesis and Assembly at the Endoplasmic Reticulum Membrane. Thermal Denaturation of Membrane Proteins. Mass Action Kinetic Analysis of Multidrug Resistance Transporters Expressed in Confluent Cell Monolayers. How to Understand Lipid–Protein Interactions in Biological Membranes. Biogenesis of Lipids and Proteins within Mitochondrial Membranes. Index.
Catalog no. K10479, July 2011, 398 pp., ISBN: 978-1-4398-0957-0, $159.95 / £99.00 Also available as an eBook
For more information and complete contents, visit www.crcpress.com
5
Biophysics Coming soon!
Introduction to BioMEMS Albert Folch University of Washington, Seattle, USA
“… a practical, historical, authoritative and comprehensive introduction to bioMEMS. … I highly recommend it.” —David J. Beebe, University of Wisconsin–Madison
“A comprehensive, colorful textbook … . I will definitely recommend to my students!” —Albert van den Berg, University of Twente
“Dr. Folch’s book is a monumental achievement which brings an authoritative and comprehensive account to the rapidly growing, multidisciplinary field of bioMEMS. Many working scientists and engineers as well as students will find this book fascinating.” —Mehmet Toner, Harvard Medical School
“It provides a visual feast of images that lead to a comprehensive understanding of many complex concepts. … It serves as an outstanding text for advanced undergraduates and graduate students, as well as an excellent review for researchers who are new to the field.” —Fawwaz Habbal, Harvard University
Read more praise at CRC Press Online
This classroom-tested book—in color throughout—covers the whole breadth of this dynamic field, including classical microfabrication, microfluidics, tissue engineering, cell-based and noncell-based devices, and implantable systems. It gives readers a real sense of how the field has grown by providing historical perspectives and covering the state of the art. The text contains over 400 color figures, most of which are from the original researchers. • • • • • • • •
Focuses on the essentials of microfabrication Presents in-depth coverage of the techniques of cell/protein micropatterning Gives a thorough presentation of microfluidics, including theory, designs, and historical perspective Explains how BioMEMS technology can increase the biochemical and biophysical complexity of cell culture microenvironments Discusses how BioMEMS devices can improve fluid handling and increase experimentation throughput Provides a good overall vision of how implantable microdevices have evolved, covering the origin of the field and the newest devices Highlights fundamental concepts and defines them in an extensive glossary Includes over 400 color figures, problem sets, design challenges, and key references
Selected Contents: How Do We Make Small Things? Micropatterning of Substrates and Cells. Microfluidics. Molecular Biology on a Chip. Cell-Based Chips for Biotechnology. BioMEMS for Cell Biology. Tissue Microengineering. Implantable Microdevices. Appendix. Index.
Catalog no. K10966, July 2012, c. 528 pp., ISBN: 978-1-4398-1839-8, $89.95 / £57.99 Also available as an eBook
Also available
Introduction to Macromolecular Binding Equilibria Charles P. Woodbury University of Illinois, Chicago, USA
Catalog no. 52985, November 2007, 272 pp. ISBN: 978-1-4200-5298-5, $104.95 / £66.99
6
Save when you order online at www.crcpress.com
Biophysics
Quantitative Understanding of Biosystems An Introduction to Biophysics Thomas M. Nordlund University of Alabama at Birmingham, USA
“The book contains a beautiful review of essential physics for understanding biological systems, particularly at the molecular scale, emphasizing that which is rarely taught in standard physics classes: how to think like a physicist. The chapters on quantum mechanics and the interaction of photons with biological systems are particularly welcome, and set this book apart. …” —Ernest Barreto, George Mason University
“This book is so far the best on the market in terms of an undergraduate biophysics textbook. … The textbook will have great success not only for the clarity of presentation, but also for its structure and numerous examples … .” —Liviu Movileanu, Syracuse University
“This is an excellent book for the physics or bioengineering undergraduate student. … written in a very clear style with plenty of useful and colorful figures. … The glossary section is an excellent tool for the student not familiar with biology.” —Diego Krapf, Colorado State University
“A superb pedagogical textbook about the behavior and properties of the microscopic structures that form the essential building blocks of living systems. … Full-color illustrations aid students in their understanding of how to use mathematical tools (graphing, calculus, simple differential equations, diagrammatic analysis, and more) to better grasp, analyze, and project solutions to problems involving the quantitative characterization of biosystems. … an excellent college text or self-instruction manual for advanced biophysics science students.” —Midwest Book Review, May 2011
Read more praise at CRC Press Online • Focuses on the biological physics of macromolecules, subcellular structures, and whole cells, including interactions with light • Provides a hands-on understanding of the movement of microorganisms, enabling readers to analyze positions, velocities, and forces of real microorganisms • Reviews the necessary mathematics, including geometry, calculus, and differential equations • Discusses quantum mechanics in biosystems, covering photosynthesis and micro and chemical reactions • Describes the transition from discreet random walks to continuum diffusive motion • Contains standard exercises, advanced problems, and miniprojects • Includes a CD-ROM with “active” versions of Excel graphs and diagrams from the text, along with links to mathematical and biological/biochemical source data
Selected Contents: Introduction, Approach, and Tools. Structure and Function. Biological Activity: Quantum Microworld. Biological Activity: (Classical) Microworld. Appendices. Glossary. Further Resources. Index.
Catalog no. 89772, March 2011, 583 pp., ISBN: 978-1-4200-8972-1, $89.95 / £57.99 Also available as an eBook
For more information and complete contents, visit www.crcpress.com
7
Biophysics
Introduction to Proteins Structure, Function, and Motion Amit Kessel Es-is Technologies Ltd., Givatayim, Israel
Nir Ben-Tal Tel Aviv University, Israel
“I was impressed both by the breadth of the topics covered and by the depth in which they are treated. General principles are made intuitively clear based on well-chosen examples, many of them having relevance to disease. The book could fit well as a textbook in structural biology and molecular biophysics courses.” —Barry Honig, Columbia University
“… the book provides general guidelines for understanding protein structure and demonstrates how we can use the structure to phrase testable hypotheses about biological function. … The book gives a coherent picture of each topic … [and] includes ample references, making it possible for the interested reader to dig deeply into various topics. … The book provides background in cell biology, basic chemistry and thermodynamics, making it useful for newcomers to the protein structure field who want to catch up quickly. … it [is also] easy for experts to dive into the more specialized aspects quickly. …” —Burkhard Rost, Technische Universität München
With more than 350 color images throughout, this text presents a unified, in-depth treatment of the relationship between the structure, dynamics, and function of proteins. Taking a structural–biophysical approach, the authors discuss the molecular interactions and thermodynamic changes that transpire in these highly complex molecules. They use numerous proteins as examples to illustrate the topics and principles and to show how proteins can be analyzed in multiple ways. The text refers to many everyday applications of proteins and enzymes in medical disorders, drugs, toxins, chemical warfare, and animal behavior. • Discusses the main experimental and computational methods used today for studying protein structure and dynamics • Presents an extensive discussion of the energetics of protein structure • Covers intrinsically unstructured proteins to provide a complete and realistic view of the proteome and to explore the full repertoire of protein functions • Describes protein–ligand interactions • Explores the industrial use of enzymes in protein engineering and the rational design of protein targeting in pharmaceutical drugs • Identifies widely used and fully accessible Internet-based resources, such as databases and algorithms • Provides downloadable questions for each chapter at www.crcpress.com
Selected Contents: Introduction. Protein Structure. Methods of Structure Determination and Prediction. Energetics and Protein Stability. Protein Structural Dynamics. Non-Globular Proteins. Membrane Proteins. Protein–Ligand Interactions. Index.
Catalog no. K10533, December 2010, 654 pp., ISBN: 978-1-4398-1071-2, $83.95 / £53.99 Also available as an eBook
8
Save when you order online at www.crcpress.com
Biophysics
New!
Physiology, Biophysics and Biomedical Engineering Edited by
Andrew W. Wood Swinburne University of Technology, Hawthorn, Victoria, Australia
Showing how biophysics and biomedical engineering have advanced modern medicine, this text provides a multidisciplinary understanding of biological phenomena and the instrumentation for monitoring these phenomena. It also explores the application of physics and engineering methods to medicine and biology. The book includes a range of numerical problems with worked solutions and offers MATLAB® code for advanced mathematical analysis of physiological and clinical monitoring systems. • Offers a multidisciplinary approach to human biological systems • Highlights the application of physics and engineering methods to medicine and biology • Gives readers a solid basis for understanding the physiological processes in the human body • Draws on the classroom material of experienced lecturers • Incorporates a range of numerical problems with worked solutions • Provides MATLAB code for advanced mathematical analysis of physiological and clinical monitoring systems • Includes references to further reading at the end of each chapter
Selected Contents: INTRODUCTION: Introduction to Physiological Systems. Fundamentals of Electrical Circuits for Biomedicine. Properties of Electrodes. MAINLY MOLECULES: Molecular Biophysics. Membrane Biophysics. Excitability and Synapses. Skeletal Muscle Biophysics. HEART AND CIRCULATION: Cardiac Biophysics. Rheology of Blood. The Vascular System: Blood Flow Patterns in Various Parts of the Circulation. Cardiovascular System Monitoring. LUNGS, KIDNEYS, AND SPECIAL MONITORING: Respiratory Biophysics. Renal Biophysics and Dialysis. Cardiopulmonary Perfusion and Advanced Surgical Techniques. THE CENTRAL NERVOUS SYSTEM: Organization of the Human Central Nervous System. The Biophysics of Sensation—General. Vision. Audition and Vestibular Sense. Chemical Senses. SYSTEMS AND SIGNALS: Physiological Signal Processing. Bioelectrical Signals: The Electroencephalogram. Magnetic Stimulation and Biomagnetic Signals. Medical Imaging. Microscopy and Biophotonics. SYSTEMS INTEGRATION: Physiological Modeling. Biomechanics and Biomaterials. Biosensors and Emerging Technologies. Answers to Questions. Index.
Catalog no. C6513, February 2012, 782 pp. ISBN: 978-1-4200-6513-8, $99.95 / £49.99 Also available as an eBook
Also available
Handbook of Physics in Medicine and Biology Edited by
Robert Splinter University of North Carolina at Charlotte, USA
Catalog no. 75241, April 2010, 548 pp. ISBN: 978-1-4200-7524-3, $159.95 / £99.00 Also available as an eBook
For more information and complete contents, visit www.crcpress.com
9
Nanotechnology New!
Nanofabrication Handbook Edited by
Understanding Nanomaterials
Stefano Cabrini Lawrence Berkeley National Laboratory, California, USA
Malkiat S. Johal
Satoshi Kawata
Pomona College, Claremont, California, USA
Osaka University, Japan
“It is rich with illustrations and the authors of the individual chapters have made a real effort to introduce readers to the basic concepts in understandable terms while also capturing the current leading edge in their field. The amazing micrographs of prototype structures that are documented throughout the pages offer an inspiring snapshot of the many and varied accomplishments of the researchers working in these technology development and application fields … a solid introduction to methods in current use in nanoscale research while the breadth of topics will also permit experienced practitioners to learn about methods and applications outside their own areas of experience.” —Donald Tennant, Cornell NanoScale Science and Technology Facility
“An impressive work covering all the important nanofabrication topics and contents … Highly recommended.” —Din Ping Tsai, National Taiwan University
Selected Contents: STANDARD LITHOGRAPHY: Introduction to Nanofabrication. Electron Beam Lithography. Nanolithography with Focused Ion Beams. Focused Ion Beam and Electron Beam Deposition. PlasmaAssisted Pattern Transfer at the Nanoscale. Optical Lithography. Soft X-Ray Lithography. Simulations in Micro- and Nanofabrication. NEW LITHOGRAPHIC TECHNIQUES: Nanoimprint Lithography. Scanning Probe Lithography. Two-Photon Lithography. Colloidal Inorganic Nanocrystals: Synthesis and Controlled Assembly. Directed Self Assembly. SelfAssembled DNA Nanostructures and DNA Devices. Emerging New Approaches. NANOFABRICATION APPLICATIONS: Nano-Electro-Mechanical Systems (NEMS). Micro- and Nanofluidics. Fabrication of Nanophotonic Structures. Patterning Magnetic Nanostructures with Ions. Plasmonic Metamaterials. Nanoelectronics. Manipulation and Nanostructuring for Biological Applications.
Catalog no. 90526, February 2012, 546 pp. ISBN: 978-1-4200-9052-9, $129.95 / £82.00
“I believe the textbook will serve students well in their goal to gain a greater understanding of why nanoscaled systems are of great interest, how they are fabricated, and how they are characterized using a wide variety of analytical instrumentation very commonly found in university and industrial settings.” —Marcus D. Lay, University of Georgia
“The writing … is very fluid. The problems and figures are good. Overall, I learned a great deal about surface science techniques … .” —Lisa Klein, Rutgers University
This book provides a coherent overview of the fundamental principles underlying nanomaterials fabrication as well as a discussion of the characterization and application of these materials. The author takes an interdisciplinary approach, highlighting the theory and tools contributed by chemistry, biology, physics, medicine, and engineering. The book includes real world examples related to energy, the environment, and medicine throughout the text, underscoring the technological applications. • Discusses the principles of nanomaterials fabrication • Describes the characterization and application of nanomaterials • Contains real-world examples, application notes, and a glossary of technical terminology • Includes worked examples, end-of-chapter problem sets, and exercises for self-study to strengthen conceptual understanding
Selected Contents: A Brief Introduction to Nanoscience. Intermolecular Interactions and Self- Assembly. Rudiments of Surface Nanoscience. Characterization at the Nanoscale. Types and Uses of Some Nanomaterials. Appendix. Glossary. Index.
Catalog no. 73109, April 2011, 327 pp. Soft Cover ISBN: 978-1-4200-7310-2, $59.95 / £38.99 Also available as an eBook
Also available as an eBook
10
Save when you order online at www.crcpress.com
Biomedical Imaging
Coherent Raman Scattering Microscopy
Nanoscopy and Multidimensional Optical Fluorescence Microscopy
Edited by
Edited by
Ji-Xin Cheng
Alberto Diaspro
Coming soon!
Purdue University, Wes Lafayette, Indiana, USA
Xiaoliang Sunney Xie Harvard University, Cambridge, Massachusetts, USA
Covering technical advances and biological applications, this authoritative compendium describes the major developments in platforms and laser sources leading to the routine use of coherent Raman microscopes. It presents the full spectrum of basic and clinical applications of real-time vibrational imaging for in vitro and in vivo systems, showing how these techniques have proven instrumental in disease studies. • Presents the core principles, technical development, current status, and diverse potential applications of coherent Raman scattering microscopy • Covers microscope construction, phase control, fiber laser sources, multimodal imaging, and spectral analysis • Provides a detailed treatment of the broad spectrum of current platforms, including wide-field, polarization, interferometric, double-resonance, and multiplex CARS • Discusses state-of-the-art applications in biomedical studies, infectious disease studies, and liquid crystals and nanomaterials research
Selected Contents:
The Italian Institute of Technology and University of Genoa, Italy
“This book certainly appears at the right time … . The book should be useful for senior research students in optical microscopy and biophotonics.” —Min Gu, Swinburne University of Technology
“A very useful book for the microscopy field. Alberto Diaspro has done a great job as editor, and I’m sure this book will be appreciated by its readers.” —Peter Saggau, Baylor College of Medicine
“… this elegant book should impress many optical manufacturers …” —Optical World, August 2010
This volume presents a complete overview of developments in optical microscopy that enable structure determination at the nanoscale, from imaging and manipulation to spectroscopy and visualization. It draws on contributions from those who have led the current upsurge in research or who have laid the foundation for the development of modern microscopes and techniques. Interdisciplinary in scope and approach, the book combines the science and tools of biologists, physicists, and engineers.
Selected Contents:
PRINCIPLES AND TECHNICAL DEVELOPMENT: Fundamentals of Spontaneous and Coherent Raman Scattering. Construction of a CARS Microscope. Multimodal Imaging and Spectral Analysis on a CARS Microscope. Stimulated Raman Scattering Microscopy. Focus-Engineering in CARS Microscopy. Wide-Field CARS. Polarization CARS. Phase Control in CARS Microscopy. Fourier-Transform CARS. … APPLICATIONS: CARS Imaging of De and Re-Myelination Ex Vivo and In Vivo. Imaging Lipid Metabolism in C. elegans and Other Model Organisms. Lipid Droplet Biology and Obesity-Related Health Risks. …
Optical Microsopy and Nanoscopy. Basis if Fluorescence Spectroscopy. Basis of Optics for Microscopy. Scanning Microscopy at the Nanoscale. 3D Computational Optical Sectioning Microscopy. Multiphoton Microscopy at the Nanoscale. Confocal Microscopy at the Nanoscale. 7D Microscopy. Lifetime Imaging Microscopy. Fluorescence Correlation Spectroscopy. FRET/FRAP. Single Molecule Microscopy. SPT. Fluorescent Probe. Fluorescence Photoactivation and Photoswitching. Fluorescent Nanotubes and Nanowires. Scattering Processes. SHG/THG Microscopy. Near Field Microscopy. TIRF Microscopy.
Catalog no. K13060, November 2012, c. 664 pp. ISBN: 978-1-4398-6765-5, $149.95 / £95.00
Catalog no. C7886, April 2010, 448 pp. ISBN: 978-1-4200-7886-2, $135.95 / £87.00 Also available as an eBook
For more information and complete contents, visit www.crcpress.com
11
Biomedical Imaging
Edited by
FLIM Microscopy in Biology and Medicine
David A. Boas
Edited by
Harvard Medical School, Charlestown, Massachusetts, USA
Ammasi Periasamy
Handbook of Biomedical Optics
Constantinos Pitris University of Cyprus, Nicosia
Nimmi Ramanujam Duke University, Durham, North Carolina, USA
“This handbook is a successful attempt to provide as much as possible information to physicists, R&D engineers, clinicians and scientists who would like to apply contemporary concepts and techniques to solve biomedical diagnostic and therapeutic challenges. It often covers areas that are not conventionally addressed, and is generally thoughtprovoking and brain-stimulating … a good balance between introductory knowledge and high-level expertise, without burdening the reader with excessive data. What makes it really unique is its scope. … the book is truly state of the art.” —Boris Gramatikov, Biomedical Engineering Online, February 2012
“… highly recommend it. It provides an in-depth review and overall treatment covering most areas of biomedicine from the ground-level foundations of optics to background on photon transport in tissues, theory, and experiments. … a major contribution to the biomedical optics field and will serve as a great resource.” —Journal of Biomedical Optics, December 2011
Taking a broad yet detailed approach, this comprehensive handbook covers light-based diagnostic methodologies and light-mediated therapeutics as well as concepts and cutting-edge optical methods used in research and practice. Extensively illustrated, the book presents the theory and fundamentals, along with state-of-the-art applications. The expert contributors also discuss advantages and disadvantages of various techniques.
Selected Contents: Background. Spectroscopy and Spectral Imaging. Tomographic Imaging. Microscopic Imaging. Molecular Probe Development. Phototherapy.
Catalog no. 90364, June 2011, 831 pp. ISBN: 978-1-4200-9036-9, $149.95 / £95.00
University of Virginia, Charlottesville, USA
Robert M. Clegg University of Illinois, Urbana, USA
“… a clear presentation of the theory, instrumentation, and data analysis of FLIM and is enhanced by the critical discussions of assumptions, limitations and confounding elements … .” —Barry R. Masters, Microscopy and Microanalysis
“… an excellent and comprehensive treatment of FRET in biology investigation. It has a good balance of basic theory and cutting-edge development in both techniques and applications.” —Peter So, MIT
“An amazingly comprehensive reference—I can’t imagine anyone looking for information there and not finding what they need. It is quite essential for any lab doing FLIM.” —Guy Cox, University of Sydney
After an overview of basic principles, this book discusses probes, dynamic and video rate FLIM imaging, laser scanning confocal FLIM, spectral lifetime imaging, nonlinear curve-fitting methods, global FLIM data analysis, and new approaches in data analysis. Recognized as pioneers in the field, the editors offer a summary chapter on current FLIM applications.
Selected Contents: Basics of Fluorescence. Basics of Microscopy. Basics of FLIM Microscopy. Probes for FLIM Microscopy. Dynamic FLIM Microscopy Imaging Using Gating Camera (Time Domain). Video Rate FLIM Imaging Microscopy (Frequency Domain). Laser Scanning Confocal FLIM Microscopy. Multiphoton-Excitation Time-Correlated Single-Photon Counting FLIM Microscopy. SLIM for Multispectral Imaging Microscopy. Nonlinear Curve-Fitting Methods for FLIM Data Analysis. Global FLIM Data Analysis. New Approaches in FLIM Data Analysis: Polar Plot. Critical Review of FLIM Applications.
Catalog no. C7890, July 2009, 472 pp. ISBN: 978-1-4200-7890-9, $107.95 / £69.99 Also available as an eBook
Also available as an eBook
12
Save when you order online at www.crcpress.com
Essential Texts Coming soon! Coming soon!
Fundamentals of Soft Matter Science Linda S. Hirst University of California, Merced, USA
“Broader in coverage than existing texts … a very good introduction to the field of soft matter.” —Gary Bryant, RMIT University
Focusing on qualitative science and experimental techniques, this book provides a comprehensive, practical introduction to the field of soft matter, which merges tools from physics, materials science, chemistry, biology, and computer science. The text first presents an overview of the field and a summary of physical principles of self-assembly in soft materials. It then covers liquid crystals, colloids, polymers, gels, and soft biomaterials, including what defines this class of materials, key properties, and common characterization methods. The author also emphasizes imaging techniques and other methods used to characterize soft materials in the lab. • Takes a highly descriptive and visual approach • Emphasizes modern imaging and other experimental techniques • Describes everyday materials applications • Provides a descriptive account of materials in each chapter • Gives balanced coverage to each major class of soft matter
Selected Contents: Introduction. Liquid Crystals. Colloids. Polymers. Gels. Soft Biological Materials.
Catalog no. K11369, November 2012, c. 240 pp. ISBN: 978-1-4398-2775-8, $79.95 / £49.99 Also available as an eBook
Optical Imaging Techniques in Cell Biology Second Edition Edited by
Guy Cox University of Sydney, New South Wales, Australia
Praise for the First Edition: “… an excellent resource for those wishing to gain a grounding in a broad range of optical techniques … a valuable addition to the bookshelf of many research laboratories … Students, technicians, and researchers will find it useful whether they are intending to use the techniques, have been using the techniques for some time, or are merely curious to know more about what the techniques can offer the cell biologist.” —Mark Prescott, Australian Biochemist
In a uniform style and format, this book covers the field from the basics of the optical microscope to highly advanced techniques, such as FRET and FLIM. It provides an understanding of the underlying principles, so that readers can understand the benefits and limitations of each technique described. Suggestions for further reading are included in each chapter.
Selected Contents: The Light Microscope. Optical Contrasting Techniques. Fluorescence and Fluorescence Microscopy. Image Capture. The Confocal Microscope. The Digital Image. Aberrations and Their Consequences. Nonlinear Microscopy. HighSpeed Confocal Microscopy. Deconvolution and Image Processing. Three-Dimensional Imaging: Stereoscopy and Reconstruction. Green Fluorescent Protein. Fluorescent Staining. Quantitative Fluorescence. Advanced Fluorescence Techniques: FLIM, FRET, and FCS. Evanescent Wave Microscopy. Beyond the Diffraction Limit. Appendices.
Catalog no. K12150, June 2012, c. 320 pp. ISBN: 978-1-4398-4825-8, $149.95 / £95.00 Also available as an eBook
For more information and complete contents, visit www.crcpress.com
13
Essential Texts
New!
Quantum Principles & Particles
Introduction to Holography
Walter Wilcox
Vincent Toal
Baylor University, Waco, Texas, USA
Dublin Institute of Technology, Ireland
“This text contains many innovative features, tricks, and other material not usually found in an undergraduate introduction to quantum mechanics. … a very welcome addition.”
“The breadth of coverage of this book is remarkable, ranging from the underlying physics, to mathematical descriptions and derivations, to the experimental aspects of the art of holography.”
—Donald N. Petcher, Covenant College
—Joseph W. Goodman, Stanford University
Inspired by the work of Nobel laureate Julian Schwinger, this extensively illustrated book provides a clear introduction to quantum mechanics using wave mechanics and spin analysis to explain the concepts of particle physics. The author’s novel pedagogical approach uses process diagrams as tools for visualizing the states and operators and for illustrating ways to compute amplitudes for quantum mechanical processes. • Emphasizes basic quantum principles deduced from fundamental experiments • Presents quantum theory in a novel way by using process diagrams as a visual tool • Guides readers from elementary quantum mechanics to aspects of particle physics • Incorporates extensive problem sets to reinforce key principles • Uses simplified bra-ket notation throughout • Contains helpful appendices on notation, lattice models, weak flavor mixing, and numerical simulations
“Each topic is accompanied with proper figures and is explained very well. …”
Selected Contents:
Selected Contents:
QUANTUM PRINCIPLES: Perspective and Principles. Free Particles in One Dimension. Some OneDimensional Solutions to the Schrödinger Equation. Hilbert Space and Unitary Transformations. Three Static Approximation Methods. Generalization to Three Dimensions. QUANTUM PARTICLES: The Three-Dimensional Radial Equation. Addition of Angular Momenta. Spin and Statistics. Quantum Particle Scattering. Connecting to the Standard Model. Appendices. Index.
OPTICS: Light, Waves, and Rays. Physical Optics. PRINCIPLES OF HOLOGRAPHY: Introducing Holography. Volume Holography. HOLOGRAPHY IN PRACTICE: Requirements for Holography. Recording Materials. Recording Materials in Practice. APPLICATIONS: Holographic Displays. Other Imaging Applications. Holographic Interferometry. Holographic Optical Elements. Holographic Data Storage and Information Processing. Digital Holography. Computer-Generated Holograms. Holography and the Behavior of Light. Polarization Holography. Holographics Sensors and Indicators. Appendices.
Catalog no. K11590, April 2012, 546 pp. Soft Cover ISBN: 978-1-4398-3525-8, $69.95 / £44.99 Also available as an eBook
—Joseph Rosen, Ben Gurion University of the Negev
“… the perfect textbook for a course on holography. I thoroughly recommend it to both students and experienced practitioners of the subject.” —Chris Dainty, National University of Ireland
“… essential reading for those involved with photonics, a primary reference worth purchasing.” —Martin Richardson, DeMontfort University
Read more praise at CRC Press Online
With more than 300 illustrations, this practical guide explains how to use holographic techniques to solve specific problems in a variety of fields. It chronicles the historical development of holography, reviews essential optics, presents basic holographic principles, and describes the conditions for successful holography in the laboratory.
Catalog no. K10987, September 2011, 502 pp. ISBN: 978-1-4398-1868-8, $99.95 / £63.99 Also available as an eBook
14
Save when you order online at www.crcpress.com
Computational and Statistical Methods
Statistical Physics of Biomolecules
Coarse-Graining of Condensed Phase and Biomolecular Systems
An Introduction
Edited by
Daniel M. Zuckerman
Gregory A. Voth
University of Pittsburgh, Pennsylvania, USA
This text brings down to earth some of the most intimidating but important theories of molecular biophysics. It covers probability theory, low-dimensional models, and the simplest molecular systems. The accessible development of equilibrium and dynamical statistical physics makes this a valuable text for readers with limited physics and chemistry backgrounds. • Develops fundamental statistical physics principles clearly and concisely • Includes a unified description of statistical mechanics, thermodynamics, and molecular biophysics built from simple probability ideas • Contains intuitive explanations for challenging but essential ideas, including entropy, free energy, and rate constants • Emphasizes the twin perspectives of dynamics and equilibrium throughout • Takes a pedagogical approach to advanced topics such as molecular computation and nonequilibrium phenomena
Selected Contents: Proteins Don’t Know Biology. The Heart of It All: Probability Theory. Big Lessons from Simple Systems: Equilibrium Statistical Mechanics in One Dimension. Nature Doesn’t Calculate Partition Functions: Elementary Dynamics and Equilibrium. Molecules Are Correlated! Multidimensional Statistical Mechanics. From Complexity to Simplicity: The Potential of Mean Force. What’s Free about “Free” Energy? Essential Thermodynamics. The Most Important Molecule: Electro-Statistics of Water. Basics of Binding and Allostery. Kinetics of Conformational Change and Protein Folding. Ensemble Dynamics: From Trajectories to Diffusion and Kinetics. A Statistical Perspective on Biomolecular Simulation. Index.
Catalog no. 73788, June 2010, 356 pp. ISBN: 978-1-4200-7378-2, $94.95 / £59.99
University of Utah, Salt Lake City, USA
Assembling some of the most influential, worldrenowned researchers in the field, this book covers developments in the coarse-grained molecular dynamics simulation and modeling of condensed phase and biomolecular systems. Each chapter focuses on specific examples of evolving coarse-graining methodologies and presents results for a variety of complex systems. • Presents the main approaches to coarsegraining, including minimalist, inversion, and multiscale • Connects atomic-level information with coarsegrained representations of complex systems, such as lipid bilayers, proteins, peptides, and DNA • Describes the challenges of coarse-graining, including the degree of “believable” predictive power of coarse-grained models and their transferability between dissimilar systems
Selected Contents: The MARTINI Force Field. The Multiscale CoarseGraining Method. A Model for Lipid Bilayers in Implicit Solvent. Coarse-Grained Dynamics of Anisotropic Systems. State-Point Dependence and Transferability of Potentials in Systematic Structural Coarse-Graining. Systematic Approach to CoarseGraining of Molecular Descriptions and Interactions with Applications to Lipid Membranes. Simulation of Protein Structure and Dynamics with the CoarseGrained UNRES Force Field. Coarse-Grained Structure-Based Simulations of Proteins and RNA. On the Development of Coarse-Grained Protein Models. Characterization of Protein-Folding Landscapes by Coarse-Grain Models Incorporating Experimental Data. Principles and Practicalities of Canonical Mixed-Resolution Sampling of Biomolecules. Pathways of Conformational Transitions in Proteins. …
Catalog no. 59556, September 2008, 456 pp. ISBN: 978-1-4200-5955-7, $174.95 / £112.00 Also available as an eBook
For more information and complete contents, visit www.crcpress.com
15
Computational and Statistical Methods Dynamical Tunneling Structural Bioinformatics
Theory and Experiment
An Algorithmic Approach
Edited by
Srihari Keshavamurthy
Forbes J. Burkowski
Indian Institute of Technology, Kanpur
University of Waterloo, Ontario, Canada
Peter Schlagheck
Showcasing the beauty of protein structures, this practical text illustrates how to apply key algorithms to solve problems related to macromolecular structure. It emphasizes a methodology that uses mathematical models to act as links between structural biology and computational algorithms. The author shows that protein structure can produce symmetry and beauty as well as biological function. He also gives many examples of dynamic programming applications, including RNA secondary structure prediction and protein sequence alignment. The text includes problems throughout, exercises at the end of each chapter, and a 12-page color insert.
Catalog no. C6838, October 2008, 429 pp. ISBN: 978-1-58488-683-9, $87.95 / £55.99
Differential Equations and Mathematical Biology Second Edition D.S. Jones, M.J. Plank and B.D. Sleeman “Much progress by these authors and others over the past quarter century in modeling biological and other scientific phenomena make this differential equations textbook more valuable and better motivated than ever. … The coauthors deserve congratulations as well as course adoptions.”
Universite de Liege, Belgium
A prominent aspect of quantum theory, tunneling arises in a variety of contexts across several fields of study. in this volume, international experts discuss the considerable progress that has been achieved in this arena in the past two decades. The book includes a historical introduction and overview of dynamical tunneling and emphasizes the semiclassical theory of tunneling. It explores developments in tunneling with cold atoms and molecular manifestations as well as advances in our ability to perform delicate and precise experiments in atomic systems. The contributors also describe the visualization and control of photonic tunneling and the role of dynamical tunneling on energy flow and localization in large molecules.
Contents: Dynamical Tunneling with a Bose–Einstein Condensate. Chaos-Assisted Dynamical Tunneling in Atom Optics. Tractable Problems in Multidimensional Tunneling. Semiclassical Analysis of Multidimensional Barrier Tunneling. Direct Regular-to-Chaotic Tunneling Rates using The Fictitious Integrable System Approach. Complex Semiclassical Approach to Chaotic Tunneling. Resonance-Assisted Tunneling in Mixed Regular-Chaotic Systems. Dynamical Tunneling from the Edge of Vibrational State Space of Large Molecules. Dynamical Tunneling and Control. Tunneling of Ultracold Atoms in TimeIndependent Potentials. Dynamic Localization in Optical Lattices. Control of Photonic Tunneling in Coupled Optical Waveguides. Quantum Discrete Breathers. Tunneling in Open Quantum Systems.
Catalog no. K10855, March 2011, 436 pp. ISBN: 978-1-4398-1665-3, $159.95 / £99.00 Also available as an eBook
—SIAM Review, September 2010
“Where this text stands out is in its thoughtful organization and the clarity of its writing. This is a very solid book … The authors succeed because they do a splendid job of integrating their treatment of differential equations with the applications … Each chapter comes with a collection of well-selected exercises, and plenty of references for further reading.” —MAA Reviews, April 2010
Catalog no. C8357, November 2009, 462 pp. ISBN: 978-1-4200-8357-6, $82.95 / £35.99
16
Save when you order online at www.crcpress.com
Forthcoming The Fluorescent Protein Revolution Edited by
Optical Techniques in Regenerative Medicine
Richard N. Day
Edited by
Indiana University, Indianapolis, USA
Stephen Morgan and Felicity R. Rose
Michael W. Davidson Florida State University, Tallahassee, USA
This reference discusses major advances in the development of novel imaging techniques that exploit new probes. It describes the photophysical properties of new fluorescent probes, particularly the important red fluorescent probes from corals. The book gives a detailed account of state-of-the-art imaging methods that exploit the characteristics of new probes. It also illustrates the applications of fluorescent probes in a variety of different optical techniques, including superresolution microscopy. Many figures throughout the text further clarify concepts. • Discusses major advancements in the development of novel imaging techniques • Gives up-to-date information on state-of-the-art imaging methods • Describes the applications of fluorescent probes in a variety of different optical techniques
University of Nottingham, UK
Steve Matcher University of Sheffield, UK
A practical guide to the most appropriate techniques for a given application, this book focuses on optical coherence tomography, acousto-optic imaging, Raman spectroscopy, machine vision, polarized light imaging, fiber optic sensors, second harmonic generation, multi-photon microscopy, coherent anti-stokes Raman scattering, and polarized light imaging. It covers applications in fundamental research and in the regenerative medicine industry for tissue engineering products.
HISTORY AND PERSPECTIVES: Introduction to Fluorescent Proteins. Development of Aequorea victoria Fluorescent Proteins. The Quest for New Fluorescent Proteins from Corals. PHOTOPHYSICAL PROPERTIES OF FLUORESCENT PROTEINS: Lessons Learned from the Structure of Aequorea Victoria Fluorescent Proteins. Development of Optimized Fluorescent Proteins. Development of New Colors from Coral Fluorescent Proteins. The Search for the Grail: Optimal Red Fluorescent Proteins. Optical Highlighters. Far Red and Near-Infared Fluorescent Proteins. APPLICATIONS: Genetically Encoded Fluorescent Proteins and FRAP. Optical Highlighters. Biosensor Probes. Probes for FRET and FLIM. Superresolution Techniques. Whole Animal Imaging with Red, Near-Infrared Probes. Future Prospects.
Each chapter gives an overview of a particular technique, its advantages and limitations in terms of structural and functional information, and examples of applications in regenerative medicine. The book also summarizes major recent advances, such as the use of machine vision for tracking growth of threedimensional constructs in bioreactors and polarization-sensitive optical coherence tomography for monitoring collagen alignment in cartilage growth. • Gives detailed background on the most important optical techniques used in regenerative medicine • Addresses the needs of the biomedical/tissue engineering industry by focusing on applied areas, such as development of new products/biological substitutes that will restore, maintain, or improve tissue function • Covers techniques for monitoring the process of three-dimensional tissue culture both in basic research and as a tool for manufacturing new regenerative medicine products • Discusses the advantages and limitations of using particular techniques in the context of various applications
Catalog no. K13481, November 2012, c. 400 pp. ISBN: 978-1-4398-7508-7, $129.95 / £82.00
Catalog no. K12560, March 2013, c. 400 pp. ISBN: 978-1-4398-5495-2, $129.95 / £82.00
Selected Contents:
Also available as an eBook
Also available as an eBook
For more information and complete contents, visit www.crcpress.com
17
Forthcoming
Adaptive Optics for Biological Imaging
Second Harmonic Generation Imaging Edited by
Edited by
Francesco S. Pavone
Joel A. Kubby
Universita degli Studi di Firenze, Sesto Fiorentino, Italy
University of CaliforniaSanta Cruz, USA
Paul J. Campagnola
Written by an international team of leaders in the field, this reference presents a complete overview of the core principles, state-of-the-art methods, and emerging applications of adaptive optics in biological imaging. It emphasizes the use of adaptive optics to correct wavefront aberrations caused by light propagation in biological samples. Accessible to readers without a background in optics, the book describes the fundamentals, components, and systems used in adaptive optics. It also covers optics systems as well as newer applications in this rapidly expanding field. • Provides the only comprehensive treatment of the principles, methods, and applications of adaptive optics in microscopy for biological imaging • Shows how to use adaptive optics in the microscopy of biological samples to improve image quality and provide deeper tissue imaging • Discusses how the wide availability of MEMS components has enabled applications of adaptive optics in fast developing areas
University of Connecticut, Farmington, USA
Selected Contents:
PRINCIPLES OF SHG IMAGING: Second Harmonic Generation: Theory. Third Harmonic Generation: Theory. Chromophores for SHG. BIOMEDICAL IMAGING USING SHG: Order and Structure with SHG. SHG Imaging of the Eye. SHG of Connective Tissue. SHC Imaging of Muscle. SHC Imaging of Micro Tubules and Other Subcellular Details. Membrane Potential Detection Using SHC Imaging. APPLICATIONS OF SHC: SHC on Self-Assembled Gels. SHC Imaging of Cardiovascular Disease. Holographic SHC Imaging. Combined SHC/THC Imaging. SHG/IHG Imaging of Fibrosis. SHG Imaging of Female Cancers (Breast and Ovary). Second Harmonic Generation in Tumors. SHG and Optical Clearing. Skin Disorder Imaging with SHG. Tissue Engineering Applications.
PRINCIPLES: Overview of Adaptive Optics. Current Adaptive Optics Systems. METHODS: Optical System Design. Optical System Assembly. Optical System Alignment. Optical System Sample Preparation. APPLICATIONS: Wide-Field Microscopy. Confocal Microscopy. Multi-Photon Microscopy. Optical Coherence Tomography.
Catalog no. K12282, March 2013, c. 300 pp. ISBN: 978-1-4398-5018-3, $99.95 / £63.99 Also available as an eBook
This book provides a complete overview of the principles underlying second harmonic generation and its current applications. Covering practical issues related to instrumentation, the text examines which kinds of external labels to use. It also gives detailed reviews of the use of second harmonic generation in biomedical research, from imaging of cancer and skin disorders to self-assembled gels, holographic SHG imaging, and tissue engineering applications. • Focuses on building a system for second harmonic generation imaging, choice of external labels, current research, and clinical uses • Gives an overview of principles underlying second and third harmonic generation imaging • Covers chromophores, biomedical imaging aspects, use of SHG for order and structure studies, imaging of microtubules, and other subcellular components
Selected Contents:
Catalog no. K12222, January 2013, c. 450 pp. ISBN: 978-1-4398-4914-9, $149.95 / £95.00 Also available as an eBook
18
Save when you order online at www.crcpress.com
Bestsellers Structure and Function of Intrinsically Disordered Proteins
Dynamics of Biological Systems
Peter Tompa
Michael Small
Hungarian Academy of Sciences, Budapest
Hong Kong Polytechnic University
“Tompa’s masterly compendium on intrinsically disordered proteins arrives at just the right time to fill a conspicuous void on this important topic. His eminently readable book is broad enough to educate beginners but deep enough to inform experts.”
Unifying diverse phenomena, this classroom-tested text shows how to apply a variety of mathematical and computational techniques to model and analyze the temporal and spatial phenomena of biological systems. The mathematical models and computer simulations offer insight into cardiac pacemakers, artificial electrical defibrillation, pandemics, pattern formation, flocking behavior, the interaction of autonomous agents, and hierarchical and structured network topologies. Exercises and projects are included in each chapter. MATLAB® implementations of algorithms and case studies are available on the author’s website. • Uses complex systems, complex networks, and dynamics to derive models and computer simulations of various biological systems • Presents a wide range of models, from ECG signal processing to pandemic modeling to population dynamics • Requires no advanced knowledge of mathematics • Includes exercises as well as computational and research projects at the end of each chapter • Offers MATLAB implementations of many key algorithms and various case studies on the author’s website
—George Rose, Johns Hopkins University
“This book demonstrates Tompa’s considerable command of the field, providing appropriate examples and ample details in every respect. … the author manages to strike a good balance between detail and concept to lead the reader through this novel field.” —Sir Alan Fersht, University of Cambridge
“The book is just superb—a thorough, comprehensive and lucid discussion of intrinsically disordered proteins.” —Joel L. Sussman, Weizmann Institute of Science
Providing the first focused and detailed treatment of protein disorder, this book illustrates how IDPs defy the structure-function paradigm and play important regulatory and signaling roles. The author includes an overview of the structure, function, and evolution of IDPs and addresses biomedical implications and protein disorder in drug development for cancer and neurodegenerative diseases.
Selected Contents: Principles of Protein Structure and Function. A Brief History of Protein Disorder. Indirect Techniques for Recognizing and Characterizing Protein Disorder. Hydrodynamic Techniques. Spectroscopic Techniques for Characterizing Disorder. Nuclear Magnetic Resonance. Proteomic Approaches for the Identification of IDPs. …
Catalog no. C7892, November 2009, 359 pp. ISBN: 978-1-4200-7892-3, $107.95 / £69.99
Selected Contents: Biological Systems and Dynamics. Population Dynamics of a Single Species. Observability of Dynamic Variables. Biomedical Signal Processing. Computational Neurophysiology. Mathematical Neurodynamics. Population Dynamics. Action, Reaction and Diffusion. Autonomous Agents. Complex Networks. Conclusion. References. Index.
Catalog no. K12463, August 2011, 284 pp. ISBN: 978-1-4398-5336-8, $79.95 / £49.99 Also available as an eBook
Also available as an eBook
For more information and complete contents, visit www.crcpress.com
19
Bestsellers
The Silicon Web
Polymer Translocation
Physics for the Internet Age
M. Muthukumar
Michael G. Raymer
University of Massachusetts, Amherst, USA
University of Oregon, Eugene, USA
“I like very much the way theoretical ideas are presented and compared with experiments. … a valuable source of information for anyone investigating polymer transport processes.”
“… a text perfect in itself and perfect for its time … . ideal for an undergraduate course required of all physical science, engineering, computer science, and mathematics majors.”
—Anatoly B. Kolomeisky, Rice University
—Physics Today
“Muthu’s incisive work beautifully clarifies the issues in polymer translocation. He offers cogent explanations of several experimental phenomena and indicates where our reasoning remains murky.”
“[A] stunningly rich story about the Internet and its associated technologies … an elegant and elaborate textbook, one that examines the science underlying the current revolution in communications technology. … All the important physics is here, but presented in an engaging way, with modern examples.”
—Hagan Bayley, University of Oxford
“It is a truly outstanding book! The author has covered a surprisingly broad range of physical questions that refer to both polymers and ion channels. … a must read for everyone who wants to get a steadfast grip over the physics of channelfacilitated polymer transport.” —Sergey M. Bezrukov, NICHD, National Institutes of Health
This book discusses the macromolecular basis of polymer translocation that has emerged based on experimentation, new models, and computational approaches. The author summarizes the phenomenon with examples and provides a firm grounding in fundamental concepts. He also addresses implications for basic research and biotechnology as well as future prospects and challenges.
Selected Contents: Translocation Phenomenon in Biology. Model Systems. Concepts and Theory. Charged Macromolecules in Electrolyte Solutions. Macromolecules under Confinement. Dynamics in Solution. Translocation through a Channel. Packaging of Viruses. Translocation through Multiple Channels. Prospects.
—Louis A. Bloomfield, author of How Things Work
From computers to optical communication, this text explores core principles underlying the technologies that continue to revolutionize our lives. Designed for nonscientists, the book requires no higher math or prior physics. It details basic physics principles at the core of information technology; examines the quantum era, discussing digital memory and computers; and then moves on to the Internet era, covering lasers, optical fibers, light amplification, and wireless technology. Going beyond the technical, the book clarifies common misconceptions while offering insight on the social impacts of science and technology. Study questions, end-of-chapter problem sets, and real-world exercises are included.
Selected Contents: Introduction to Physics, Silicon, and the Internet. Principles of the IT Revolution. The Quantum Era: Digital Memory. The Internet Era: Optical Fibers, Light Amplification, Fiber Optics, Wireless Communication.
Catalog no. K10173, June 2009, 600 pp. ISBN: 978-1-4398-0311-0, $96.95 / £61.99
Catalog no. 75160, May 2011, 372 pp. ISBN: 978-1-4200-7516-8, $99.95 / £63.99 Also available as an eBook
20
Save when you order online at www.crcpress.com
General Intellectual Property in Academia A Practical Guide for Scientists and Engineers Edited by
Nadya Reingand CeLight, Inc, Silver Springs, Maryland, USA
This book provides a practical understanding of IP basics relevant in an academic environment. It describes the process of performing a comprehensive prior art search, determining business value, filing for a patent, licensing to companies, and using follow-up patents to create a valuable portfolio. The text also covers starting a new business and recent changes in application procedures. • Provides complete step-by-step guidance on how to proceed with inventions in an academic environment • Addresses the critical issue of ownership of the legal rights to intellectual discoveries at the university developed under various types of contracts • Gives detailed practical instructions on estimation of the market niche and monetary value of the invention • Offers guidance in the witchcraft of efficient prior art search by using various techniques • Teaches readers how to use electronic patent databases • Shows the IP limitations associated with different types of contract funding • Discusses Offices of Technology Transfer and efficient ways to communicate with them
Selected Contents: Patent Basics. Prior Art Searching. Valuation of Technology-Based IP in Academia. Drafting a Patent Application. Electronic Filing of US Patents. Filing University Patent Applications through an Office of Technology Transfer. University Patent Revenue Generation: Case Studies. Copyright. Index.
Catalog no. K11674, October 2011, 352 pp. Soft Cover ISBN: 978-1-4398-3700-9, $49.95 / £31.99 Also available as an eBook
Commonly Asked Questions in Thermodynamics Marc J. Assael, William A. Wakeham, Anthony R.H. Goodwin, Stefan Will, and Michael Stamatoudis “This is an extremely useful book for anybody teaching thermodynamics.” —Jan V. Sengers, University of Maryland
“… should be in every engineering library [and] listed as a reference text in all engineering thermodynamics courses. A wide range of topics are covered starting with simple questions and gradually advancing to more complex questions. The answers are clear and easy to follow. The last chapter is particularly useful as a guide to where to find property values, how to use those values and how to calculate thermodynamic and transport properties.” —Ken Marsh, University of Canterbury
This clearly written, easy-to-follow guide allows even nonscientists considering use of alternative fuel sources to achieve a solid grounding in thermodynamics. The authors cover topics spanning from energy sources to the environment to climate change. • Answers the most commonly asked questions relating to thermodynamics, such as the difference between entropy and enthalpy and the first name of Maxwell’s demon • Precedes each group of related questions with an introductory overview • Emphasizes qualitative understanding • Includes many illustrative materials throughout to reinforce key concepts • Requires no prior background in the subject
Selected Contents: Definitions and the 1st Law of Thermodynamics. What Is Statistical Mechanics? 2nd Law of Thermodynamics. Phase Equilibria. Reactions, Electrolytes, and Nonequilibrium. Power Generation, Refrigeration, and Liquefaction. Where Do I Find My Numbers?
Catalog no. 86952, March 2011, 368 pp. Soft Cover ISBN: 978-1-4200-8695-9, $39.95 / £25.99 Also available as an eBook
For more information and complete contents, visit www.crcpress.com
21
General
Measured Tones Physics of Sailing
The Interplay of Physics and Music, Third Edition
John Kimball
Ian Johnston
University of Albany, New York, USA
University of Sydney, New South Wales, Australia
“The chapter on fluid dynamics sets this book apart by its skeptical and pragmatic approach … Kimball puts each idea in its place showing where its strengths and weaknesses are. In doing so he provides a rare overview which so many books fail to give. … it should be a standard introduction to any fluid dynamics course.”
“Ian Johnston has managed to appeal to a physicist with an interest in music, to a musician with an interest in physics or even a general reader who is merely interested. … I devoured the book from cover to cover and thought overall that it was a wonderful read. It is exactly the sort of book that I hope someone would buy me as a present (if I did not already have a copy). It is now a treasured part of my personal library.”
—R.S. Shorter, Contemporary Physics, 2011
“… an excellent introduction to the forces that enable sailboats to perform … . John Kimball has contributed a readable explanation of the physics behind sailing that will appeal to a wide range of technically oriented readers.” —James Harper, University of New Hampshire
“I like the book very much. It is well written …” —Bryon D. Anderson, Kent State University
Breaking down the complicated concepts of speed, acceleration, torque, fluid mechanics, and surface physics, this book provides a lively, easily accessible introduction to the basic science underlying the sport of sailing. It illustrates the many ways physics can be used to understand the principles of sailboat propulsion and how a scientific understanding of the boat, wind, and water can lead to more skillful sailing.
Selected Contents: Depart, Depart from Solid Earth. Downwind—The Easy Direction. Upwind—The Hard Direction. Tipping, Torques, and Trouble. See How the Mainsail Sets. Fluid Dynamics. Surfaces. Waves and Wakes. Wind. Strategy. Finally. Sailing Glossary. Index.
Catalog no. 73761, December 2009, 296 pp. Soft Cover ISBN: 978-1-4200-7376-8, $49.95 / £32.99 Also available as an eBook
22
—Contemporary Physics, 2010
Using an informal historical approach, this book shows the evolution of the theory and application at the intersection of physics and music. Updated to consider modern technology, this new edition features a greater examination of MP3 design. It also includes information on the gamelan and other Asian instruments and discusses binary notation, digitization, and the electronic manipulation of music. A supplementary website provides sound files and instructional support. • Updates information to encompass modern technology, such as MP3 and binary notation • Features additional information on Asian percussion instruments • Explores psycho-acoustics in greater depth • Covers recent advances, especially in digitization
Selected Contents: Why These and Not Others? Music and Scientific Method. Harmonies of a Mechanical Universe. Overtones of Enlightenment. Over the Waves. The Romance of Electricity. Summertime in Heidelberg. O brave New World. I think, Therefore I am.
Catalog no. 93479, June 2009, 454 pp. ISBN: 978-1-4200-9347-6, $64.95 / £41.99 Also available as an eBook
Save when you order online at www.crcpress.com
Quick Reference Guides from A.C. Fischer-Cripps Fischer-Cripps Laboratories Pty Ltd, Sydney, Australia
The Physics Companion
The Electronics Companion
“… great quick reference guide for professional physicists … easy to quickly find those equations that you don’t frequently use but suddenly need. You will find it quicker in this book than you will find it in a textbook.”
This companion covers the core topics of electrical engineering, providing a logical and consistent account of the way in which basic electronic circuits are designed and how they work. The text contains many worked examples and review questions throughout. It also includes a laboratory section describing experiments that can be carried out by students in their own time or under the supervision of an instructor.
—The Physicist
“Fischer-Cripps has prepared an excellent compendium of definitions and relationships from mainly classical physics. … a valuable resource for all students of physics … highly recommended …”
Catalog no. IP704, October 2004, 288 pp. Soft Cover ISBN: 978-0-7503-1012-3, $33.95 / £21.95
—American Library Association
Catalog no. IP737, March 2003, 384 pp., Soft Cover ISBN: 978-0-7503-0953-0, $33.95 / £21.95
The Mathematics Companion Mathematical Methods for Physicists and Engineers “… it is very well done, and everything that might be expected to be there is there … invaluable for those undergraduate students in Mathematics, Science or Engineering who need to undertake first and second year courses in Mathematics, and it will serve those who wish to have quick access to all those formulae that seem to be so readily forgotten.” —J.M. Hill, Australian Physics
Catalog no. IP721, May 2005, 210 pp., Soft Cover ISBN: 978-0-7503-1020-8, $33.95 / £21.95 Also available as an eBook
The Chemistry Companion Suitable as an introduction or study guide, this book offers concise summaries of general chemistry concepts, easily accessible in a convenient, reader-friendly format. It presents the minimum of what readers need to know to understand the subject. Emphasizing the physics underlying chemistry, the book enables readers to better appreciate what is happening from the chemical perspective that is usually found in traditional chemistry books.
Catalog no. K11517, August 2011, 195 pp. Soft Cover ISBN: 978-1-4398-3088-8, $29.95 / £18.99 Also available as an eBook
The Materials Physics Companion “It is a straightforward and easy-to-read book with many examples that clearly illustrate many different concepts … It can really help to explain principles that often are not so easy to understand in traditional physics text…” —Electrical Insulation Magazine
Catalog no. C6803, August 2007, 208 pp., Soft Cover ISBN: 978-1-58488-680-8, $33.95 / £21.95
For more information and complete contents, visit www.crcpress.com
23
6000 Broken Sound Parkway, NW, Suite 300 Boca Raton, FL 33487, USA
Page 9
Page 17
For a complete list of Biophysics books, please visit www.crcpress.com
Page 6
EZL01_ISSUU