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Contents Biomaterials & Medical Devices ........................3 Bioprocessing....................................................5 Nanobiotechnology ..........................................7 Biotechnology ................................................11 Page 3
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Medicine & Biology ........................................16 Drug Discovery & Delivery ............................18 Industry Applications ......................................21
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Biomaterials & Medical Devices
New!
Coming Soon!
Biomimetics
ISO 13485
Nature-Based Innovation Edited by
A Complete Guide to Quality Management in the Medical Device Industry
Yoseph Bar-Cohen
Itay Abuhav
JPL/Caltech, Pasadena, California, USA
Hinterforst, Switzerland
Humans have always looked to nature’s inventions as a source of inspiration. In recent years these efforts have become more intensive, with researchers seeking rules, concepts, and principles of biology to inspire new possibilities in materials, mechanisms, algorithms, and fabrication processes. A review of the current state of the art, Biomimetics: Nature Based Innovation documents key biological solutions that provide a model for innovations in engineering and science. With contributions from leading experts, the book explores a wide range of applications across a variety of fields. Offering myriad examples of technologies inspired by biology, the book discusses artificial senses and organs; mimicry at the cell–materials interface; and modeling of plant cell wall architecture and tissue mechanics. It also covers biomimetic composites; artificial muscles; refreshable braille displays; biomimetic optics; and the mimicking of flying birds, insects, and marine biology. A series of chapters examines applications of biomimetics in manufacturing, products, medicine, and robotics—including medical devices, implants, and the development of human-like robots. Contributors also explore biologically inspired design as a tool for interdisciplinary education and describe the biomimetic process in artistic creation. The final chapter outlines the challenges to biomimetic-related innovation and offers a vision for the future. A follow-up to Biomimetics: Biologically Inspired Technologies (2005), this comprehensive reference methodically surveys the latest advances in this rapidly emerging field. It features an abundance of illustrations, including a 32-page fullcolor insert, and provides extensive references for engineers and scientists interested in delving deeper into the study of biomimetics.
The United States and European Union now require the ISO 13485 Standard certification for medical device manufacturers. Written by an experienced industry professional, this practical book provides a complete guide to the ISO 13485 Standard certification for medical device manufacturing in terms of quality control. It covers all the requirements of ISO 13485 and offers a step-by-step comparison between the ISO 13485 and ISO 9001, enabling a sound understanding of these new procedures.
Features: • Elucidates the ISO 13485 Standard requirements in detail • Compares the ISO 13485 with the ISO 9001 • Emphasizes applications of risk management to the quality controls of medical devices • Includes real-world examples drawn from the author’s experiences in the medical device industry • Offers extensive references
Selected Contents: Scope Normative References Terms and Definitions Requirements Quality Management System Management Responsibility Resource Management Product Realization Measurement, Analysis, and Improvement Catalog no. K12946, October 2011, c. 408 pp. ISBN: 978-1-4398-6611-5, $129.95 / £82.00
Catalog no. K11566, September 2011, 788 pp. ISBN: 978-1-4398-3476-3, $159.95 / £99.00
For more information and complete contents, visit www.crcpress.com
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Biomaterials & Medical Devices New!
Biological and Biomedical Coatings Handbook Two-Volume Set Edited by
Sam Zhang Nanyang Technological University, Singapore
Important in today’s nanotechnology, biological and biomedical coatings have been studied extensively and are currently receiving much attention from researchers. Providing a timely reference for both experts and newcomers, this comprehensive handbook explores the latest developments in films and coatings for biological and biomedical applications. The text covers a wide array of material types, including sol-gel, bio-ceramics, polymers, glass, nanomaterials, and chitosan. It also addresses various processes for developing and implementing these coatings, including CVD and PVD, drug delivery, released-control coatings, and spectroscopy. • Presents cutting-edge developments from world leaders in films and coatings research • Serves as a simplified introductory stepping stone for new entrants to the field • Gives experts up-to-date figures, tables, plots, and images to aid their own work
Buy the Set and Save! Catalog no. K11126, May 2011, 976 pp., ISBN: 978-1-4398-2125-1, $249.95 / £159.00 Also available as an eBook
Also Available Individually Processing and Characterization
Applications
Selected Contents:
Selected Contents:
Bonelike Mineral and Organically Modified Bonelike Mineral Coatings. Synthesis and Characterization of Hydroxyapatite Nanocoatings by Sol–Gel Method for Clinical Applications. Hydroxyapatite and Other Biomedical Coatings by Electrophoretic Deposition. Thermal Sprayed Bioceramic Coatings: Nanostructured Hydroxyapatite (HA) and HA-Based Composites. Nanostructured Titania Coatings for Biological Applications: Fabrication an Characterization. Hydrothermal Crystallization with Microstructural Self-Healing Effect on Mechanical and Failure Behaviors of Plasma-Sprayed Hydroxyapatite Coatings. Bioceramic Coating on Titanium by Physical and Chemical Vapor Deposition. Coating of Material Surfaces with Layerby- Layer Assembled Polyelectrolyte Films. Bioactive Glass-Based Coatings and Modified Surfaces: Strategies for the Manufacture, Testing, and Clinical Applications for Regenerative Medicine.
Sol-Gel Derived Hydroxyapatite Coatings on Metallic Implants: Characterization, In Vitro and In Vivo Analysis.Amorphous Carbon Coatings for Biological Applications. Biomedical Applications of Carbon-Based Materials. Impedance Spectroscopy on Carbon-Based Materials for Biological Application. Control of Drug Release from Coatings: Theories and Methodologies. Release-Controlled Coatings. Orthopedic and Dental Implant Surfaces and Coatings. Piezoelectric Zinc Oxide and Aluminum Nitride Films for Microfluidic and Biosensing Applications. Medical Applications of Sputter-Deposited Shape Memory Alloy Thin Films. Bioactive Coatings for Implanted Device.
Catalog no. K12269, May 2011, 456 pp. ISBN: 978-1-4398-4995-8, $139.95 / £89.00 Also available as an eBook
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Catalog no. K12270, May 2011, 520 pp. ISBN: 978-1-4398-4996-5, $139.95 / £89.00 Also available as an eBook
New & Essential Books in Biotechnology from CRC Press
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Biomaterials & Medical Devices
Bioprocessing
Biomaterials
Coming Soon!
A Nano Approach
Disposable Bioprocessing Systems
Seeram Ramakrishna, Murugan Ramalingam, T.S. Sampath Kumar, and Winston O. Soboyejo From a multi-disciplinary point of view, this book examines basic concepts, various processing methodologies, and techniques involved in the preparation and characterization of nanobiomaterials that are specific to biomedical applications. It describes how basic concepts in nanotechnology are applied to the processing of novel nanobiomaterials, including nanostructured metals and alloys. Presenting illustrative examples and a variety of applications, this text offers a solid framework for understanding present and future trends of biomaterials in human health care systems. Catalog no. 47817, 2010, 372 pp., SBN: 978-1-4200-4781-3, $99.95 / £69.99 Also available as an eBook
Porous Media Applications in Biological Systems and Biotechnology Edited by
Kambiz Vafai University of California, Riverside, USA
Presenting state-of-the-art research advancements, this volume explores innovative approaches to effectively apply existing porous media technologies to biomedical applications. World-class scientists and engineers address significant problems and discuss exciting research in biological systems. They cover various transport processes, mechanical behavior, and material properties of biological tissues from a porous media point of view. The book also presents pertinent aspects of experimental work and numerical techniques and discusses the modeling of several phenomena, including flow changes in cerebral aneurysms, biomass growth, marine systems, and tissue homeostasis and repair.
Sarfaraz K. Niazi Pharmaceutical Scientist Inc. Deerfield, Illinois, USA
Disposable systems are close to reaching the stage of development where they can replace current drug manufacturing methods using stainless steel systems in their entirety and at any manufacturing size, overcoming a long-held disadvantage. This book describes in detail the state-of-the-art systems used or under development for the manufacturing of biological drugs using disposable systems. The text covers the current status of these systems, their regulatory status worldwide, comparisons of various types of systems and their selection criteria, cost comparisons and specific recommendations, and designs of systems to be used in different types of manufacturing operations.
Features: • Presents state-of-the art information on disposable systems • Discusses regulatory compliance of disposable systems • Covers the integration of disposable systems in a new or existing facility • Provides cost comparisons of various systems and scalability • Includes facility designs to accommodate disposable systems
Selected Contents: The Bioprocessing Industry—An Introduction. Safety of Disposable Systems. Containers. Mixing Systems. Disposable Bioreactors. Connectors and Transfers. Controls. Downstream Processing. Filling and Finishing Systems. Filtration. Regulatory Compliance. Environmental Concerns. The Epilogue. Catalog no. K12983, November 2011, c. 327 pp. ISBN: 978-1-4398-6670-2, $149.95 / £95.00
Catalog no. 65416, August 2010, 632 pp. ISBN: 978-1-4200-6541-1, $149.95 / £95.00 Also available as an eBook
For more information and complete contents, visit www.crcpress.com
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Bioprocessing Macroporous Polymers Production Properties and Biotechnological/ Biomedical Applications Edited by
The Metabolic Pathway Engineering Handbook Two-Volume Set Edited by
Christina D. Smolke Stanford University, California, USA
Christina Smolke, who recently developed a novel way to churn out large quantities of drugs from genetically modified brewer’s yeast, is regarded as one of the most brilliant new minds in biomedical engineering. In this handbook, she brings together pioneering scientists from dozens of disciplines to provide a complete record of accomplishment in metabolic pathway engineering. With a wealth of cutting-edge material, this work is an invaluable resource for those seeking to add their own contributions to the field.
Buy the Set and Save! Catalog no. 3923, 2010, 1259 pp. ISBN: 978-0-8493-3923-3, $257.95 / £164.00 Also available as an eBook
Also Available Individually Fundamentals Catalog no. K10164, 2010, 678 pp. ISBN: 978-1-4398-0296-0, $164.95 / £102.00 Also available as an eBook
Tools and Applications Catalog no. 77651, 2010, 581 pp. ISBN: 978-1-4200-7765-0, $164.95 / £102.00 Also available as an eBook
Bo Mattiasson, Ashok Kumar, and Igor Galeaev Macroporous polymers are rapidly becoming the material of choice for many tissue engineering, bioseparation, and bioprocessing applications. Presented in a systematic way, this book addresses the production, characterization, and application of these polymers. The text considers traditional methods of production, including phase separation polymerization, leaching, foaming, and double emulsion, as well as emerging methods such as cryogelation. The chapters also detail the various applications of macroporous gels for the separation of biomolecules and for the cultivation of mammalian cells in bioreactors, as well as for tissue engineering.
Features: • Includes hundreds of black-and-white illustrations, 30 tables, and a four-page color insert • Summarizes research on preparation of macroporous cryogels via free-radical polymerization and points to future perspectives • Describes different leaching techniques that have been used to fabricate porous polymer solids for biomedical applications • Provides an overview of the techniques used for the characterization of porous hydrogels by describing the potential of each particular method and its limitations • Discusses the polymerization of polyesters by ring opening polymerization, scaffold fabrication techniques, surface modification of polyester scaffolds to improve cell culture properties, and selection of a suitable bioreactor for a given scaffold Catalog no. 84615, 2010, 525 pp. ISBN: 978-1-4200-8461-0, $133.95 / £85.00 Also available as an eBook
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New & Essential Books in Biotechnology from CRC Press
MBCBH81_5.5x8.5_MC_ISSUU:MBCBH81_ISSUU 8/16/11 10:53 AM Page 7
Nanobiotechnology New! New Edition of a Bestseller!
Nanotechnology Understanding Small Systems, Second Edition
Applied Optics Fundamentals and Device Applications Nano, MOEMS, and Biotechnology
Ben Rogers, Sumita Pennathur, and Jesse Adams
Mark A. Mentzer US Army Research Laboratory, Aberdeen Proving Ground, Maryland, USA
Praise for the First Edition “It uncovers the most important things about nanotechnology explained in a very illustrative manner with many simple examples, figures, and ‘back-ofthe-envelope’ calculations, so that the reader can get a good feeling for the numbers of nanotechnology.” —Zentralblatt MATH, 1185
This book works from the ground up to provide a detailed yet accessible introduction to one of the world’s fastest growing fields, understandable to members of a variety of disciplines. It contains a clear presentation of real-world examples and original illustrations as well as hundreds of homework problems of varying types, including multiple choice, true-false, in-depth calculation, and essay (with complete solutions manual). This book uses a systems-based approach that illustrates how underlying areas of nano are assembled to create systems with unique functions and characteristics, comparing nanoscale and macroscale systems to reveal the complex and fundamental differences between phenomena at different scales and uncover the specific challenges and opportunities of nano.
Features: • Comprehensive glossary helps readers review concepts and book material as well as understand other more complex texts • Suggestions for further reading at the end of each chapter give readers a portal into deeper study of nanotech topics • Numerous updates and improvements to the text and figures, based on user feedback Solutions manual is available upon qualifying course adoption.
Catalog no. K12225, July 2011, 421 pp. ISBN: 978-1-4398-4920-0, $99.95 / £63.99 Also available as an eBook
Providing an interdisciplinary look at optics technology, this book investigates the connection between nanotechnology, MOEMS, and biotechnology. It covers fundamental relationships and system applications and includes design examples and numerous useful references. The author discusses emerging technologies, such as MEMS, MOEMS, nanotechnology, biotechnology, fiber optic sensing, and integrated optics, along with specialized military applications.
Features: • Serves as a reference for professionals and academics in a variety of disciplines • Combines coverage of the fields of biotechnology and electrical engineering as a convergent optical discipline • Offers case studies to help readers understand how emerging optics technologies are applied in the marketplace • Presents a host of application examples, fabrication and manufacturing techniques, and testing methodologies
Selected Contents: Introduction to Convergent Disciplines in Optical Engineering: Nano, MOEMS, and Biotechnology Electro-Optics Acousto-Optics, Optical Computing, and Signal Processing Fiber-Optic Sensors Integrated Optics Optical Diagnostics and Imaging MEMS, MOEMS, Nano, and Bionanotechnologies Catalog no. K11430, May 2011, 368 pp. ISBN: 978-1-4398-2906-6, $129.95 / £82.00 Also available as an eBook
For more information and complete contents, visit www.crcpress.com
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Nanobiotechnology From David E. Reisner
New!
Colloids and Interfaces in Life Sciences and Bionanotechnology Second Edition Willem Norde Wageningen University and University Medical Center Groningen, The Netherlands
This classroom-tested reference presents a concise introduction to the physicochemical principles that determine interrelated colloidal and interfacial phenomena and their relevance to various life sciences. The book focuses on concepts that form the basis for understanding this behavior. Whether deciphering the spontaneous assembly of amphiphilic molecules or the intentional fouling of surfaces for the immobilization of cells in bioreactors, this book devotes special attention to reversible and soft colloids. It discusses the colloidal domain in a historical perspective, the size and distribution of particles, electrokinetic phenomena, and more. Catalog no. K10890, June 2011, 495 pp. ISBN: 978-1-4398-1718-6, $129.95 / £39.99 Also available as an eBook
Particulate Systems in Nano- and Biotechnologies Edited by
Wolfgang Sigmund, Hassan El-Shall, Dinesh O. Shah, and Brij. M. Moudgil Regarding absorbed films and particle technology as a foundation for nano- and biotechnology innovations, this book offers comprehensive coverage of important topics in this area and summarizes developments occurring worldwide over the past decade. Experts from European, Australian, Asian, and North American research centers—including the National Science Foundation's Engineering Research Center for Particle Science and Technology—offer critical perspectives in each of their specific research areas, examine the status of technology, and define the challenges that future research must address. Catalog no. 7436, 2009, 385 pp. ISBN: 978-0-8493-7436-4, $162.95 / £102.00 Also available as an eBook
8
New!
Bionanotechnology II Global Prospects Edited by
David E. Reisner The Nano Group, Inc., Manchester, Connecticut, USA
A blend of information from the Biomedical Engineering Handbook and new material, this book draws on the experience of experts from countries such as Iran, Cuba, South Africa, UK, Canada, China, India, and Russia. It reflects the increasing importance of nanomedicine and biotechnology with the inclusion of topics such as biomimicry, stem cells, optical togs, nanocoating for medical implantable devices, food industry, cardiac diagnosis, batteries, drug delivery, photonics, DNA building blocks, protein devices, quantum dots, bioanalysis, optics, personalized medicine, and emerging bionanotech companies. Catalog no. K10254, August 2011, 583 pp. ISBN: 978-1-4398-0463-6, $99.95 / £63.99
Bionanotechnology Global Prospects Edited by
David E. Reisner The Nano Group, Inc., Manchester, Connecticut, USA
Featuring chapters drawn from the third edition of the bestselling Biomedical Engineering Handbook as well as new contributions, this text takes a broad survey of the research and activities that are shaping the burgeoning field of bionanotechnology. Covering technical and non-technical areas, it discusses the role of nanotechnology in novel medical devices, bioanalytical technologies, and nano-biomaterials as well as intellectual property issues that are unique to nanotechnologies. Catalog no. 7528, 2009, 368 pp. ISBN: 978-0-8493-7528-6, $97.95 / £61.99 Also available as an eBook
New & Essential Books in Biotechnology from CRC Press
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Nanobiotechnology New!
Nanobiomaterials Handbook Edited by
Medical Nanotechnology and Nanomedicine
Balaji Sitharaman
Harry F. Tibbals
State University of New York at Stony Brook, USA
University of Texas Southwestern Medical Center, Dallas, USA
Nanobiomaterials exhibit distinctive characteristics, including mechanical, electrical, and optical properties, which make them suitable for a variety of biological applications. Because of their versatility, they are poised to play a central role in nanobiotechnology and make significant contributions to biomedical research and healthcare. Nanobiomaterials Handbook provides a comprehensive overview of the field, offering a broad introduction for those new to the subject as well as a useful reference for advanced professionals. Analyzing major topics and disciplines in this arena, this volume:
This accessible guide reviews advances in nanoscience and nanotechnology and considers their applications in medicine. Providing an introduction to both the science and the infrastructure required to support these advances, this volume is written for non-experts, which can include medical researchers and clinicians, as well as those concerned with business aspects, regulation, and the administration of medical practices. The book provides a contextual background including history, definitions, and recent trends, and then investigates current and future nanotech applications in medicine and the biomedical sciences.
• Defines the field of nanobiomaterials and discusses its scope, current status, and future prospects
Features:
• Presents an in-depth survey of nanobiomaterials and examines various synthesis and processing techniques important for developing nanobiomaterials • Explores the unique nanoscopic physicochemical properties of nanobiomaterials • Discusses potential applications, emphasizing unique challenges in the design, fabrication, and evaluation of biomaterials for a particular application or field • Provides a detailed overview of the interactions between bionanomaterials/ biological systems and the biocompatibility issues associated with bionanomaterials Advances in nanobiomaterials require a multidisciplinary approach spanning major fields in physical sciences, biological sciences, engineering, and medicine with considerable interaction and collaboration with ethicists, regulatory bodies, and industry. This volume brings together the work of a team of world-renowned experts from various fields who discuss the vast potential for nanobiomaterials in a myriad of applications.
• Lays out a strategic plan for applying nanotechnology to high-impact medical applications • Provides a summary of current developments in the field along with future directions, applications, and impacts of nanotechnology on medicine • Presents an overview of the emerging influence of nanoscience • Enhances awareness and provides a foundation from which decisions and planning can be implemented • Employs an easily accessible and free-flowing style with representative examples, case summaries, and graphical illustrations Catalog no. K10431, January 2011, 527 pp. Soft Cover, ISBN: 978-1-4398-0874-0 $69.95 / £44.99 Also available as an eBook
Catalog no. 94661, June 2011, 737 pp. ISBN: 978-1-4200-9466-4, $169.95 / £108.00 Also available as an eBook
For more information and complete contents, visit www.crcpress.com
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Nanobiotechnology New!
New!
DNA LiquidCrystalline Dispersions and Nanoconstructions
Micro and Nano Techniques for the Handling of Biological Samples
Yuri M. Yevdokimov, V.I. Salyanov, S.V. Semenov, and S.G. Skuridin The discovery of the spatial structure of the double-stranded DNA molecule is one of the greatest achievements of science. It would not be an exaggeration to say that the DNA double helix is a distinguished symbol of modern biology. Divided into three parts, DNA Liquid-Crystalline Dispersions and Nanoconstructions covers the information presently available on the condensation of various forms of DNA and describes practical applications of the peculiar properties of the liquid-crystalline particles. • Part 1 describes the main methods used for condensation of linear high- and low-molecular mass DNA, including their complexes with polycations and circular DNA
Jaime Castillo-León, Winnie Edith Svendsen, and Maria Dimaki Technical University of Denmark, Lyngby
The techniques and tools used to understand many biological problems must be able to handle biological material without damaging or altering its natural state. This timely book assesses various micro and nano techniques available to handle these materials. It shows how the techniques can effectively manipulate biological samples and highlights the advantages and shortcomings of each technique. The authors also help readers understand how the manipulation tools work and how to determine the appropriate tool for their needs. Catalog no. K11354, August 2011, 255 pp. ISBN: 978-1-4398-2743-7, $129.95 / £82.00
• Part 2 compares the state and reactivity of double-stranded nucleic acid molecules fixed spatially in the liquid-crystalline as well as the same molecules under intracellular conditions
Digital Microfluidic Biochips
• Part 3 explains how the discovery of the fundamental principles underlying the formation of nucleic acid liquid-crystalline dispersion particles opens a gate for the operational use of these principles in the area of nanotechnology and biosensorics
Design Automation and Optimization
With detailed coverage of DNA liquid crystals, this book provides an understanding of the condensation of various forms of DNA. Doublestranded nucleic acids, spatially organized in a liquid-crystalline structure, represent an important polyfunctional tool for molecular biology and nanobiotechnology. The possibility of programmed and controlled variations in the properties of these molecules and in the characteristics of their liquid-crystalline dispersions provides wide options for the formation of biologically active three-dimensional structures with unique, widely applicable properties.
Cisco Systems, Cary, North Carolina, USA
Catalog no. K13273, August 2011, 304 pp. ISBN: 978-1-4398-7146-1, $139.95 / £89.00
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Krishnendu Chakrabarty Duke University, Durham, North Carolina, USA
Tao Xu Microfluidics-based biochips combine electronics with biochemistry for emerging application areas such as point-of-care medical diagnostics, on-chip DNA analysis, automated drug discovery, and protein crystallization. This book envisions an automated design flow for microfluidic biochips. It offers automation solutions for problems unique to digital microfluidics. The authors provide a comprehensive methodology for the automated design, test, and use of robust and lowcost manufactured digital microfluidic systems. Using real-life bioassays as examples, they offer a comprehensive set of practical methodologies and tools for chip design and manufacture. Catalog no. K11010, 2010, 213 pp. ISBN: 978-1-4398-1915-9, $139.95 / £89.00 Also available as an eBook
New & Essential Books in Biotechnology from CRC Press
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Biotechnology Coming Soon!
OMICS Biomedical Perspectives and Applications Edited by
Debmalya Barh Institute of Integrative Omics and Applied Biotechnology, West Bengal, India
Kenneth Blum and Margaret A. Madigan LifeGen, San Diego, California, USA
Omics is a general term for science and engineering disciplines involved in analyzing the interaction of biological informational objects in various omes. Reflecting the explosion of research and development in this area, this volume explores applications of omics in bioinformatics, cancer research and therapy, diabetes research, plant science, molecular biology, and neurosciences. Worldwide experts have each written specific chapters in this comprehensive volume which highlights proteomics and genomics. Detailed references are included at the end of each chapter to enhance further study. Catalog no. K12277, November 2011, c. 608 pp. ISBN: 978-1-4398-5008-4, $139.95 / £89.00
New!
Biotechnology Fundamentals Firdos Alam Khan Manipal University, Dubai, UAE
This textbook discusses the fundamentals of biotechnology as well as the latest developments such as stem cell research, cloning, biofuel, transgenic plants, genetically modified food or crops, pharmacogenomics, nano-biotechnology. Incorporating extensive pedagogy into the content, the authors provide examples, end-ofchapter problems, case studies, and laboratory tutorials. They include definitions, historical perspectives, time lines, and major discoveries along with the major segments of biotechnology, products, current R & D, career prospects, ethical issues, and future trends.
Features: • Includes information pertaining to current research trends • Covers novel medical genetics topics such as intra-uterine insemination • Discusses the process of biotech product development with suitable examples
Environmental Microbiology for Engineers
• Examines ethical issues within biotechnology research and product development, including embryonic stem cells, cloning, gene therapy, and GM crops
Volodymyr Ivanov
Solutions manual is available upon qualifying course adoption.
Nanyang Technological University, Singapore
Selected Contents:
Designed specifically for engineers with little or no biology training, this book covers diversity and function of microorganisms in environmental engineering systems, environmental bioengineering processes, applied microbial genetics and molecular biology, microbiology of water and wastewater treatment, biotreatment and bioremediation, and microbial monitoring. It also explores biocorrosion of constructions, biodeterioration of materials, biocementation and bioclogging of soil, biopollution of indoor environment, and biofouling of facilities. Each chapter includes quizzes and tutorials.
What is Biotechnology. Microbial Biotechnology. Agricultural Biotechnology. Animal Biotechnology. Environmental Biotechnology. Industrial Biotechnology. Medical Biotechnology. Nanobiotechnology. Biotechnology Product Development. Ethics in Biotechnology. Current Research Topics. Career in Biotechnology. Glossary. Index. Catalog no. K11059, August 2011, 654 pp. ISBN: 978-1-4398-2009-4, $89.95 / £48.99
Solutions manual is available upon qualifying course adoption.
Catalog no. 92340, November 2010, 438 pp. ISBN: 978-1-4200-9234-9, $99.95 / £63.99 Also available as an eBook
For more information and complete contents, visit www.crcpress.com
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Biotechnology Coming Soon!
New!
Boron Science New Technologies and Applications
Methods for Studying DNA/Drug Interactions Edited by
Meni Wanunu
Edited by
University of Pennsylvania, Philadelphia, USA
Narayan S. Hosmane
Yitzhak Tor
Northern Illinois University, Dekalb, USA
University of California, San Diego, USA
Boron Science: New Technologies and Applications addresses the applications of boron in chemistry, industry, medicine, and pharmacology. It explains boron’s role in problems such as catalysis and hydroboration as well as its use in superconductors, materials, magnetic/nonmagnetic nanoparticles, and medical applications including cancer therapy. More than just an updated compilation of progress in the applied science of boron, this book is a tribute to the legions of workers who have spent years conducting groundbreaking studies. It celebrates these scientists and their protégés, who together transformed boron science into the exciting and growing area it is today.
Selected Contents: Boron for Living: Medicine: New Opportunities in Boron Chemistry for Medical Applications. ... Boron for Living: Health and Nutrition: The Role of Boron in Human Nutrition and Metabolism. Boron for Living: Radioisotope: Isotope Incorporation Using Organoboranes. Boron Cluster (Radio) Halogenation in Biomedical Research. Boron for Living: Boron Neutron Capture Therapy: Recent Developments in the Boron Neutron Capture Therapy Driven by Nanotechnology. Liposomal Boron Delivery System for Neutron Capture ... Boron for Electronics: Optoelectronics: Boron Derivatives for Application in Nonlinear Optics. ... Boron for Energy: Energy Storage, Space, and Other Applications: Boron Chemistry for Hydrogen Storage. Oilfield Technology and Applications Involving Borates. ... Boron for Chemistry and Catalysis: Catalysis and Organic Transformations: ConstrainedGeometry Titanacarborane Monoamides: From Synthesis and Reactivity to Catalytic Applications. ...
This book describes emerging, non-conventional methods for probing the interactions of small molecules with nucleic acids as well as modern computational methods for assessment. By highlighting novel methods for nucleic acid/ligand interactions, the text presents drug developing companies with a survey of possible future techniques as well as their drawbacks and advantages with respect to common techniques. In addition, and perhaps more importantly, this book is designed to inspire young scientists to continue and advance these methods into fruition, especially in light of current capabilities for assay miniaturization and enhanced sensitivity using microfluidics and nanomaterials.
Selected Contents: Optical Tweezers and Single-Molecule Detection of Drug Binding. Magnetic Tweezers and Drug Binding Assays. Fluorescence Correlation Spectroscopy (FCS) for Analyzing Nucleic Acid/Drug Complexes. RNA Fluorescent Base Analogs + Small Molecule Interaction. Profiling Nucleic Acid/Drug Interactions Using Synthetic Pores. Carbon Nanotube-Based Detection of DNA/Drug Complexes. Impedance Sensing of DNA Binding Drugs Using Metal Electrodes. Electrochemical Methods for Studying Nucleic Acid/Small Molecule Interactions. On-bead Assays for Gene Targets. Surface Plasmon Resonance for Detecting DNA/Ligand Interactions. Surface Plasmon Resonance Techniques for Studying RNA/Ligand Interactions. Molecular Modeling of RNA Drug Complexes. Vibrational Spectroscopy of RNA-Drug Complexes. Selection Techniques for Identifying LigandBinding RNA Motifs. Modeling and Characterization of G-quadraplex SmallMolecule Binders. ... Catalog no. K11829, December 2011, c. 400 pp. ISBN: 978-1-4398-3973-7, $119.95 / £76.99
Catalog no. K11300, September 2011, 856 pp. ISBN: 978-1-4398-2662-1, $299.95 / £191.00
12
New & Essential Books in Biotechnology from CRC Press
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Biotechnology Sensors for Chemical and Biological Applications Edited by
Manoj Kumar Ram and Venkat R. Bhethanabotla This reference supplies versatile, hands-on tools for professionals working in a broad array of disciplines. It offers a detailed discussion of the potential of chemical and biochemical sensors in medical science, food quality, biological, and environmental applications. Examining the role of nanotechnology in sensor development, it explores how sensors confront challenges of chemical-bioterrorism through enhanced specificity, fast response times, and the ability to determine multiple hazardous substances. The text also includes examples of sensor usage, such as cholesterol monitoring, along with extensive references.
Features: • Provides a comprehensive overview of chemical and biochemical sensors • Covers applications of the solid-state gas sensor in the control and monitoring of chemical processes and living environments • Discusses the increasing importance of micro electromechanical systems (MEMS) and surface acoustic wave (SAW) in sensor applications • Explores the importance of biosensor in the measurement of food quality and environmental quality • Includes coverage of advanced techniques for detection of bio-chemical warfare agents Catalog no. 3366, 2010, 390 pp. ISBN: 978-0-8493-3366-8, $129.95 / £82.00 Also available as an eBook
New!
Gene Biotechnology Third Edition William Wu, Helen H. Zhang, Michael J. Welsh, and Peter B. Kaufman Covering state-of-the-art technologies and a broad range of practical applications, the Third Edition of Gene Biotechnology presents tools that researchers and students need to understand and apply today's biotechnology techniques. Many of the currently available books in molecular biology contain only protocol recipes, failing to explain the principles and concepts behind the methods outlined or to inform the reader of possible pitfalls in the methods described. Filling these gaps, this book: • Discusses a wide variety of approaches, from very basic methods to the latest, most sophisticated technologies • Contains clearly detailed, step-by-step protocols with helpful troubleshooting tips • Addresses the needs of researchers in academic and commercial environments • Guides graduate students in designing, implementing, and evaluating experimental projects Each chapter covers the principles underlying methods and techniques, and includes step-bystep descriptions of each protocol, notes, tips, and a troubleshooting guide. The book includes often overlooked sections on how to write a research paper for publication in English-language journals, how to protect research discoveries and inventions via patents, and practical methods of bio-calculation. Written by a team of internationally recognized scientists, this book presents protocols, as well as clear and simple explanations of the key principles and concepts behind the methods. It is a single, logically organized source for all the most important new methodologies. This unique resource provides the tools to help ensure success in contemporary molecular and cellular biology research. Catalog no. K12153, May 2011, 575 pp. ISBN: 978-1-4398-4830-2, $149.95 / £95.00 Also available as an eBook
For more information and complete contents, visit www.crcpress.com
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Biotechnology New!
Support Vector Machines and Their Application in Chemistry and Biotechnology Yizeng Liang, Qing-Song Xu, HongDong Li, and Dong-Sheng Cao Support vector machines (SVMs) are used in a range of applications, including drug design, food quality control, metabolic fingerprint analysis, and microarray data-based cancer classification. While most mathematicians are wellversed in the distinctive features and empirical performance of SVMs, many chemists and biologists are not as familiar with what they are and how they work. Presenting a clear bridge between theory and application, this text provides a thorough description of the mechanism of SVMs from the point of view of chemists and biologists, enabling them to solve difficult problems with the help of these powerful tools. Topics discussed include: • Background and key elements of SVMs and applications in chemistry and biotechnology • Elements and algorithms of support vector classification (SVC) and support vector regression (SVR) machines, along with discussion of simulated datasets • The kernel function for solving nonlinear problems by using a simple linear transformation method • Applications of support vector machines to near-infrared data • Support vector machines and quantitative structure-activity/property relationship (QSAR/QSPR) • Quality control of traditional Chinese medicine by means of the chromatography fingerprint technique Beneficial for chemical data analysis and the modeling of complex physic-chemical and biological systems, support vector machines show promise in a myriad of areas. This book enables non-mathematicians to understand the potential of SVMs and utilize them in a host of applications. Catalog no. K11127, May 2011, 211 pp. ISBN: 978-1-4398-2127-5, $119.95 / £76.99 Also available as an eBook
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Colloids in Biotechnology Edited by
Monzer Fanun Al-Quds University, East Jerusalem, Palestine
Colloids show great potential in a wide variety of applications, including drug delivery and medical imaging. This book describes developments in the field of biotechnological applications and bridges the gap between these research efforts and commercially viable options. The authors discuss new types of biosurfactants; mixtures of surfactants; and peptides, proteins, and polyelectrolytes. They describe the formation and properties of magnetic colloids and review their applications in chemical biology and medicine. They also highlight progress in the design of self-assembled materials for biotechnology and cover the formation of nanofibres and the use of sol-gel technology in biology. Catalog no. K11511, September 2010, 547 pp. ISBN: 978-1-4398-3080-2, $159.95 / £99.00 Also available as an eBook
Systems Biology and Bioinformatics A Computational Approach Kayvan Najarian, Christopher N. Eichelberger, Siamak Najarian, and Shahriar Gharibzadeh Emphasizing computational methods, this volume provides an introduction to systems biology and its impact on biology and medicine. The book reviews the basic principles of molecular and cell biology using a system-oriented approach, with a brief description of the highthroughput biological experiments that produce databases. It includes techniques to discover genes, perform nucleotide and amino acid sequence matching, estimate static gene dynamic pathways, and predict the behavior of biological systems for important applications. Catalog no. 46500, 2009, 190 pp. ISBN: 978-1-4200-4650-2, $71.95 / £45.99 Also available as an eBook
New & Essential Books in Biotechnology from CRC Press
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Biotechnology
New!
Bioseparation Technology Neeraj Mishra and Akhilesh Dubey Designed for those with a background in engineering or biology, this reference explores the fundamentals of the emerging field of bioseparation technology. It begins with an introduction to bioprocesses and provides focused chapters on cell disruption, filtration, centrifugation, adsorption, and extraction. The book also examines membrane separation processes, precipitation, chromatography, electrokinetic and methods of separation as well as finishing operations and formulation. Catalog no. N10039, August 2011, 300 pp. Soft Cover, ISBN: 978-1-4398-0172-7 $49.95 / £31.99
Essentials of Biotechnology R.C. Sobti and Suparna S. Pachouri Punjab University
A comprehensive treatise on biotechnology, this volume starts with a review of applications that scientists employed long before the field was defined. It then moves on to examine the emergence of current methods and specialized tools in the field, as well as cell culture and nucleic acid based technologies. It devotes individual chapters to biotechnology in the areas of health, agriculture, environment, aquaculture, and food. These are followed by chapters on the status of biotechnology in developing countries, with special reference to India. It also discusses debated ethical considerations and explores issues regarding intellectual property rights and patents. Catalog no. AB8284, 2009, 750 pp. ISBN: 978-1-4200-8284-5, $129.95 / £83.00
Illustrated Dictionary of Biotechnology
Emerging Protein Biotherapeutics Edited by
Himanshu Arora
Iqbal S. Grewal
Helping to support a common language in this rapidly evolving field, the Illustrated Dictionary of Biotechnology includes a range of terms wide enough to satisfy the needs of any researcher, clinician, lawyer, investor, student, or instructor whose work involves contact with new advances in science and medicine. In clear and lucid English, it provides straightforward definitions and invaluable background information so that even complex terms require only a rudimentary understanding of the life sciences. Extensive cross-referencing expands individual definitions and enables readers to follow a chosen theme. Illustrations are included where they enhance understanding.
Given the speed at which antibody therapy is becoming readily accepted, a comprehensive industry guide is sorely needed. Written by leading international authorities, this book maintains an overall emphasis on various therapeutic approaches and applications and provides critical discussions on the most significant areas of research in biologics. It focuses on the applications of protein biologics in autoimmunity and inflammation, hematological malignancies, and solid tumors.
Catalog no. N10040, 2009, 450 pp., Soft Cover ISBN: 978-1-4398-0173-4, $61.95 / £39.99
Preclinical Therapeutics, Seattle Genetics, Inc., Bothell, Washington, USA
Catalog no. 63200, 2009, 368 pp. ISBN: 978-1-4200-6320-2, $164.95 / £105.00 Also available as an eBook
For more information and complete contents, visit www.crcpress.com
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Medicine & Biology New!
BioMEMS Science and Engineering Perspectives Simona Badilescu and Muthukumaran Packirisamy Concordia University, Montreal, Canada
Biomedical Microsystems Ellis Meng University of Southern California, Los Angeles, USA
Covering often overlooked areas in the field of BioMEMS, this volume spans topics associated with biomolecules and complex biological entities, as well as subjects directly linked to the design, fabrication, and characterization of devices. Unlike other references, this text aids in the fundamental physiochemical understanding of biological processes relevant to the performance of various biosensing devices. Useful for upper-level undergraduate and graduate students enrolled in engineering programs, the book includes problems in each chapter, in addition to case studies that provide real-life examples.
Written by an active researcher recently named one of Technology Review’s Young Innovators Under 35, this book begins with an introduction to the benefits of miniaturization. It introduces materials, fabrication technology, and the necessary components of all BioMEMS. The author covers fundamental principles and building blocks, including microfluidic concepts, lab-ona-chip systems, and sensing and detection methods. The final chapters explore several important applications of BioMEMS, such as microdialysis, catheter-based sensors, MEMS implants, neural probes, and tissue engineering. Detailed examples, exercises, and illustrations help elucidate the concepts.
Features:
Features:
• Provides a concise overview of BioMEMS principles
• Presents a rigorous, in-depth treatment of BioMEMS materials, methods, processes, and concepts
• Incorporates modern applications • Covers fabrication techniques
• Emphasizes practical knowledge useful for application to real-world problems
• Offers examples, problems, references, review questions, and case studies to aid in comprehension
• Describes research and commercialized BioMEMS devices as well as emerging applications
Solutions manual is available upon qualifying course adoption.
Selected Contents: Introduction. Substrate Materials Used in BioMEMS Devices. Biomolecules and Complex Biological Entities: Structure and Properties. Engineering of Bioactive Surfaces. Methods of Study and Characterization of Surface-Modified Substrates. Biosensing Fundamentals. Fabrication of BioMEMS Devices. Introduction to Microfluidics. BioMEMS: Life Science Applications. Catalog no. K10877, April 2011, 368 pp. ISBN: 978-1-4398-1699-8, $99.95 / £63.99 Also available as an eBook
• Includes detailed examples, laboratory exercises, and a variety of homework problems • Contains numerous illustrations of concepts, processes, and devices Solutions manual and downloadable original images are available upon qualifying course adoption.
Selected Contents: Introduction. BioMEMS Materials. Microfabrication Methods and Processes for BioMEMS. Microfluidics. Lab-on-a-Chip or Micro Total Analysis Systems. Sensing and Detection Methods. Applications to Cells, Nucleic Acids, and Proteins. Clinical Monitoring. MEMS Implants and Bioelectric Interfaces. Index. Catalog no. 51229, September 2010, 408 pp., ISBN: 978-1-4200-5122-3, $89.95 / £49.99 Also available as an eBook
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New & Essential Books in Biotechnology from CRC Press
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Medicine & Biology The Delivery of Regenerative Medicines and Their Impact on Healthcare Edited by
Catherine D. Prescott Biolatris Ltd., Cambridge, UK
Dame Julia Polak Imperial College, London, UK
Based on input from an international panel of experts, this book provides first-hand experience of the challenges and opportunities facing the delivery of regenerative medicines to patients. It highlights key issues beyond science and clinical translation, such as finance and business models, intellectual property and regulatory landscapes as well as questions of how regenerative medicines will be evaluated for reimbursement. It also covers legal issues relevant to regulators, insurers, and investors as well as pharmaceutical and biotech researchers. Catalog no. K11628, November 2010, 400 pp. ISBN: 978-1-4398-3606-4, $169.95 / £108.00 Also available as an eBook
Biology for Engineers Arthur T. Johnson University of Maryland, College Park, USA
This entry-level text minimizes unnecessary memorization of connections and classifications and emphasizes concepts, technology, and the utilization of living things. Filled with practical examples, the book discusses biological responses from the perspectives of psychology, human factors, genetics, plant and animal physiology, imaging, control systems, actuary, and medicine. Offering numerous tables of useful information, it covers the scaling of biological responses and attributes as well as different types of applications related to biological systems. Solutions manual is available upon qualifying course adoption.
Catalog no. 77635, September 2010, 775 pp. ISBN: 978-1-4200-7763-6, $99.95 / £44.99 Also available as an eBook
New!
Mechanobiology Handbook Edited by
Jiro Nagatomi Clemson University, South Carolina, USA
Introduction to Complexity and Complex Systems Robert B. Northrop
At appropriate levels, mechanical stimuli are necessary for growth and maintenance of healthy tissues and organs. Mechanobiology examines effects of mechanical force stimuli on cellular biological functions. The past two decades have seen a dramatic increase in the level of research in mechanobiology. Collecting cutting-edge research findings from a diverse range of scientists, this volume, which presents basic materials in mechanics and cell biology, is a reference for those new to the field and is designed to stimulate new ways of thinking in current mechanobiology researchers.
Written for students and professionals in the fields of biomedical engineering, systems biology, biophysics, and physiology, this unique reference covers complexity issues within living systems. Topics include human responses to coping with complex systems, the Law of Unintended Consequences, the relation of complexity to evolution, and the complexity inherent in invertebrate immune systems and in economic systems. A comprehensive glossary, dynamic models, and homework questions are also included.
Catalog no. 91212, March 2011, 563 pp. ISBN: 978-1-4200-9121-2, $169.95 / £109.00 Also available as an eBook
Catalog no. K11775, December 2010, 551 pp. ISBN: 978-1-4398-3901-0, $79.95 / £44.99 Also available as an eBook
University of Connecticut, Storrs, USA
For more information and complete contents, visit www.crcpress.com
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Drug Discovery & Delivery Fundamentals of Microfluidics and Lab on a Chip for Biological Analysis and Discovery Paul C.H. Li
Neurobiology of Huntington’s Disease Applications to Drug Discovery Edited by
Donald C. Lo Duke University Medical Center, Durham, North Carolina, USA
Simon Fraser University, Burnaby, British Columbia, Canada
Robert E. Hughes
Authored by one of the field’s pioneering researchers, this volume focuses on all key aspects of the microfluidic lab-on-a-chip technologies to offer an exceptionally cohesive overview of the science, its limitations, breakthroughs made over the years, and emerging advances. The book emphasizes analytical applications of microfluidic technology and presents in-depth coverage of micromachining methods, microfluidic operations, chemical separations, sample preparation and injection methods, detection technology, and various chemical and biological analyses. Other topics of interest include the use of polymeric chips, fluid flow valve and control, single-cell analysis, DNA and RNA amplification techniques, DNA hybridization, immunoassays, and enzymatic assays.
“The book is written lucidly by authorities in their respective fields, covering clinical features, pathogenic mechanisms, protein interactions, preclinical models, biomarkers, small molecules and other approaches (eg, recombinant antibodies), screening strategies, and drug development. Informative figures and tables are provided, and reproduction of key figures as a set of colour plates provides a useful centrepiece. One unifying message is that the polyglutamine expansion leads to a complex cascade of diverse molecular and cellular events, the progress of which is difficult to slow or halt. Innovative approaches described, such as the target validation process of the Cure Huntington's Disease Initiative (CHDI) Foundation, will be of interest to those studying other neurological diseases.”
Buck Institute for Age Research, Novato, California, USA
—Anthony J. Hannan, writing in The Lancet Neurology, March 2011
Features: • Reviews fundamentals of micromachining and fluid flow and control for lab-on-a-chip • Includes information that is key to cell, nucleic acid, protein, and genetic analyses, including DNA sequencing • Adapts traditional principles of operations for the size of a chip, optimizing the miniaturization advantage and favorable scaling down • Contains tables that summarize related materials and problem sets that test comprehension of the material • Includes a glossary and extensive references along with a four-page color insert Solutions manual is available upon qualifying course adoption.
Catalog no. K10977, 2010, 418 pp., Soft Cover ISBN: 978-1-4398-1855-8, $99.95 / £38.99 Also available as an eBook
Highlighting advances in the discovery and development of drug therapies for neurodegenerative disorders, this book focuses on the many aspects of the research on drugs to treat Huntington's disease. It discusses genetics, genomics, and proteomics, and the latest in high-throughput and high-content screening. The authors provide introductory background as well as highly sophisticated information on current and future directions of research. Exploring the interplay between academic and industrial research, the investment community, and nonprofit contributors, the book also examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage.
Features: • Discusses drug discovery in neurodegenerative disease • Addresses the increasing role of non-profit organizations in the discovery and development of novel treatments • Bridges the gap between academic and industrial disease research Catalog no. 9000, July 2010, 338 pp. ISBN: 978-0-8493-9000-5, $149.95 / £95.00 Also available as an eBook
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New & Essential Books in Biotechnology from CRC Press
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Drug Discovery & Delivery 3D Cell-Based Biosensors in Drug Discovery Programs Microtissue Engineering for High Throughput Screening
Handbook of Analysis of Oligonucleotides and Related Products Edited by
Jose V. Bonilla
William S. Kisaalita
Girindus America, Cincinnati, Ohio, USA
University of Georgia, Athens, USA
G. Susan Srivatsa
Written by William Kisaalita, one of the foremost experts in this field, this book provides information—from theory to practice—on challenges and opportunities for incorporating 3D cell-based biosensors or assays in drug discovery programs. It supplies a historical perspective and defines the problem 3D cultures can solve. It also discusses how genomics and combinatorial chemistry have changed the way drug are discovered and presents data from the literature to underscore the less-than-desirable pharmaceutical industry performance under the new paradigm.
ElixinPharma, Encinitas, California, USA
Features: • Provides a deep comparative analysis of 2D and 3D cultures • Uses data from peer-reviewed publications to conclusively provide the justification for use of 3D cell cultures in cell-based biosensors (assays) for high throughput screening • Includes difficult-to-find information such as patents, cell lines or types commonly used in drug discovery programs, and their origins • Addresses research needs mainly in areas of detection and scaffold engineering • Describes microenvironment factors for creating phenotypes that resemble their in vivo counterparts • Incorporates case studies in support of 3D cell-based biosensor adoption in drug discovery programs Catalog no. 73494, 2010, 404 pp. ISBN: 978-1-4200-7349-2, $129.95 / £82.00 Also available as an eBook
“This is a unique resource for guiding the analysis of oligonucleotide-based drug products. No other single source provides such a comprehensive overview of the necessary analytical techniques that assess the qualitative characteristics of oligonucleotides intended for pharmaceutical use.” —Rachel R. Chennault, Ph.D. (American College of Clinical Pharmacy), in Doody's Notes
Oligonucleotides represent one of the most significant pharmaceutical breakthroughs in recent years, showing great promise as diagnostic and therapeutic agents for malignant tumors, cardiovascular disease, diabetes, viral infections, and many other degenerative disorders. This volume is an essential reference manual on the practical application of modern and emerging analytical techniques for the analysis of this unique class of compounds. A strong collaboration among thirty leading analytical scientists from around the world, the book provides readers with a comprehensive overview of the most commonly used analytical techniques and their advantages and limitations in assuring the identity, purity, quality, and strength of an oligonucleotide intended for therapeutic use.
Features: • Presents a unique compilation of the latest techniques for the analysis of oligonucleotides • Explores the current status of regulatory expectations for clinical development of this novel technology • Provides bioanalysis of oligonucleotides in support of therapeutic development • Describes practical applications that can be readily implemented in research, development, or QA/QC laboratories Catalog no. K11050, February 2011, 511 pp. ISBN: 978-1-4398-1993-7, $139.95 / £89.00 Also available as an eBook
For more information and complete contents, visit www.crcpress.com
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Drug Discovery & Delivery Second Edition of a Bestseller!
Antisense Drug Technology Principles, Strategies, and Applications, Second Edition Edited by
Stanley T. Crooke ISIS Pharmaceuticals Inc., Carlsbad, California, USA
“… provides valuable insights into the great opportunities that are presented by this technology.” —Dr. Kees Fluiter, The University of Amsterdam, in ChemMedChem, Vol. 4, 2009
“This edition is a cutting edge document including up-to-date cited references and a variety of compelling clinical case studies, and it of course retains the superb basic principles and background to antisense drug technologies featured in the first edition.” —Gary Evans, Industrial Research Ltd., in Journal of Medicinal Chemistry, 2008, Vol. 51, No. 5
Extensively revised and updated, this second edition incorporates lessons learned from first generation clinical trials, evaluates the technology as a whole, and offers new directions and avenues of research and development. The book explains mechanisms of action, pharmacokinetics of delivery, and the therapeutic potential of antisense drugs, oligonucleotides, hybridizationbased drugs, duplex RNA, and more. Leading researchers discuss improvements to second generation drugs and consider the potential of antisense drugs for the alleviation of cardiovascular diseases, metabolic diseases, inflammatory diseases, cancer, neurological disorders, and immune modulation.
New!
Transdermal and Intradermal Delivery of Therapeutic Agents Application of Physical Technologies Ajay K. Banga Mercer University, Atlanta, Georgia, USA
Interest in drug delivery systems is growing as the delivery of many drugs continues to be a problem. This is especially true for biologic medicines. Transdermal delivery is an important part of such systems, and the use of physical enhancement methods to penetrate the skin barrier is where the field is headed. This book reviews the strategies available for the delivery of compounds into and through the skin. It also focuses on technological developments in nanotechnology that can be exploited to enhance the transdermal delivery of drugs. Catalog no. K10285, May 2011, 309 pp. ISBN: 978-1-4398-0509-1, $129.95 / £82.00 Also available as an eBook
Drug Device Combination Products Delivery Technologies and Applications Edited by
A. Lewis Biocompatibles, UK
• Examines chemistries and mechanisms including 2’ methoxyethyl chimeras and duplex RNA • Illustrates concepts with numerous tables, as well as black-and-white illustrations and color figures • Features contributions from leaders in the field, including the CEO of ISIS Pharmaceuticals, a nationally recognized expert in the field of biotechnology
Drug delivery systems represent a vast area of research and development within biomaterials and medicine and the demand for sophisticated drug delivery devices continues to drive novel product development. Illustrating how effective drug delivery can be achieved by means other than oral tablets, this book provides a thorough analysis of the fundamentals, applications, and new technologies of drug-device combination products for use throughout the human body. Topics include areas of application and the development of drug-device combination products.
Catalog no. 8796, 2008, 848 pp. ISBN: 978-0-8493-8796-8, $257.95 / £164.00 Also available as an eBook
Catalog no. N10136, 2010 ISBN: 978-1-4398-2479-5, $244.99 / £155.00 Also available as an eBook
Features:
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New & Essential Books in Biotechnology from CRC Press
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Industry Applications From Esteemed Author – Syed Imtiaz Haider
Biotechnology A Comprehensive Training Guide for the Biotechnology Industry Syed Imtiaz Haider and Anika Ashtok Julphar Gulf Pharmaceutical Industries, United Arab Emirates
All manufacturing companies face the daunting task of designing an employee training matrix that meets the gamut of national and international regulatory standards. Answering the call for a one-stop training resource that focuses exclusively on this multifaceted, high-tech industry, this book provides ready-to-implement training templates that save time and expense without cutting corners on critical elements. This complete, single-source reference contains 28 complete biotechnology courses and a customizable CD-ROM with hands-on training tools. The book also provides time-saving information on how to orient employees involved in writing and executing batch manufacturing and in-process control documents.
Key Benefits: • Contains adaptable training text, test summaries and papers, test answers, and certificates of completion • Streamlines the training process, maximizing efficiency • Boosts the marketing edge over competitors This valuable training tool presents step-by-step guidance for optimizing research and development expenditures, avoiding marketing delays, gaining a competitive advantage, reducing product development failures, developing skilled manpower, and maintaining local and international regulatory compliance.
Catalog no. 84488, 2009, 868 pp., Soft Cover ISBN: 978-1-4200-8448-1, $102.95 / £65.99 Also available as an eBook
Selected Contents: Microbial Growth Text. Culturing Microorganisms. Bioreactor Configurations Text. Bioreactor Design Features Text. Lyophilization: Growing with Biotechnology Text. Shear Effects in Culture Text. Energy Input in Bioreactors Text. Downstream Processing Text. Mammalian Cell Cultures Text. Plant Cell Cultures Text. Fermentation Text. Characteristics of Cells in Culture Text. Cell Lysis Text. Cells Fractionation Text. Centrifugation Text. Homogenization Text. Refolding of Inclusion Bodies Text. Solubilization and Refolding of Proteins Text. Inclusion Bodies Solubilization Text. Sludge Treatment Text. Freeze Drying Text. Vacuum Drying Text. Diafilteration Text. Partition Chromatographs Text. Adsorption Chromatographs Text. Gel Filteration Chromatographs Text. Techniques of Genetic Engineering Text. Industrial Biosafety Text. Certificate of Attainment. Biotechnology Training Records. Recommended Readings. Appendix A ICH Harmonised Tripartite Guideline. Appendix B Guidance for Industry by U.S. Department of Health and Human Services – Food and Drug Administration – Center for Biologics Evaluation and Research (CBER) – February 1999. Appendix C EMEA European Medicine Agency Guideline. Index.
For more information and complete contents, visit www.crcpress.com
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Industry Applications From Esteemed Author – Syed Imtiaz Haider
Quality Control Training Manual Comprehensive Training Guide for API, Finished Pharmaceutical and Biotechnologies Laboratories Syed Imtiaz Haider and Erfan Asif Syed Julphar Gulf Pharmaceutical Industries, United Arab Emirates
A valuable tool for chemists and analysts working in quality control laboratories, this book provides technical solutions that fulfill training requirements and build skilled manpower. The text is written for practitioners in quality control laboratories, product development laboratories, and stability laboratories in pharmaceutical and bio-pharmaceutical manufacturing, along with students in pharmaceutical and biotechnology development. It includes chapters on various elements commonly used in quality control labs, with questions at the end to ensure understanding.
Features:
A Comprehensive Guide for the Pharmaceutical and Biotechnology Industries Syed Imtiaz Haider and Erfan Syed Asif Julphar Gulf Pharmaceutical Industries, United Arab Emirates
With over 20 easy-to-use template protocols for cleaning validation of extensively used equipments, this book provides technical solutions to assist in fulfilling the training needs of finished pharmaceutical manufacturers. Drawing on the authors’ more than two decades of experience, the text offers hands-on training based on current approaches and techniques. The manual is organized as a database to support those involved in the development, manufacturing, auditing, and validation of bio-pharmaceuticals on a pilot scale that can lead to scaled-up production. It also provides exclusive training guidelines on CD-ROM to enable the users to amend or adapt processes as necessary.
Features:
• Identifies local and international regulatory compliances • Includes end-of-chapter questions on various elements used in quality control labs • Provides training manuals and training log • Contains ready-to-use Method Validation Master Plan templates • Includes a CD-ROM that provides additional material
Selected Contents: Preface. Analytical Methods, Techniques and Quality Measures for General. Pharmaceutical Products. Analytical Methods and Techniques for Biological Products. Laboratory Training Manual. Assessment of Training Procedures. Training Assessment (Quiz and Answers). Training Log. Methods Master Validation Plan. HPLC re-Qualification SOP. GC Re-Qualification SOP. GLP Functions Dos/Donts. Catalog no. K12268, February 2011, 484 pp. ISBN: 978-1-4398-4994-1, $139.95 / £89.00 Also available as an eBook
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Cleaning Validation Manual
• Includes 23 easy-to-use template protocols for cleaning validation of extensively and most commonly used equipments, with sampling points identified through pictures • Covers a wide range of active ingredients, including their level of solubility in water and potency/toxicity so as to provide an easy way for validation professionals to create a worst-case matrix for different equipment • Provides a complete tool to understand, learn, and implement a validation program
Selected Contents: CLV-1 How to Establish a Cleaning Validation Program. CLV-2 Introduction. CLV-3 Scope and Approach. CLV-4 Cleaning Validation Team Members and Responsibilities. CLV-5 Cleaning Validation Philosophy, Strategies, and Methodology. CLV-6 Planning Phase. ... CLV42.4 Qualifi cation and Validation. CLV-43 Sampling Tools. CLV-44 Recommended Readings. Catalog no. K11299, 2010, 608 pp. ISBN: 978-1-4398-2660-7, $139.95 / £89.00 Also available as an eBook
New & Essential Books in Biotechnology from CRC Press
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Industry Applications New!
Biotechnology Operations Principles and Practices Michael J. Roy University of Wisconsin-Madison, USA
Because of rapid developments in the biotechnology industry—and the wide range of disciplines that contribute to its collective growth—there is a heightened need to more carefully plan and fully integrate biotech development projects. Despite the wealth of operations experience and associated literature available, no single book has yet offered a comprehensive, practical guide to fundamentals. Filling the void, Biotechnology Operations: Principles and Practices reflects this integrative philosophy, serving as a practical guide for students, professionals, or anyone else with interests in the biotech industry. Although many books emphasize specific technical aspects of biotech, this is perhaps the first to integrate essential concepts of product development and scientific and management skills with the seven functional areas of biotechnology: • • • • • • •
Biomanufacturing Clinical trials Nonclinical studies Project management Quality assurance Quality control Regulatory affairs
A practical roadmap to optimizing biotechnology operations, this reference illustrates how to use specific product planning, design, and project management processes to seamlessly merge plans and efforts in the key functional areas. Applying lessons learned throughout the nascent history of biotech, author Michael Roy highlights developmental principles that could bring future products to market more safely and efficiently. Drawing from his experiences working in industry and teaching a graduate course at the University of Wisconsin, this hotly anticipated book clarifies basic methodologies and practices to help reduce risks and resolve problems as future technological discoveries are developed into tangible products.
Features: • Provides an introduction to each key biotechnology development subject, all compiled in one volume • Incorporates an integrated approach, tying together the seven key functional areas • Emphasizes the need to both plan and integrate an operations program, offering the information required to successfully lead such efforts • Uses relatively simple language, clarifies jargon, and uses diagrams to describe processes, making concepts easy to understand
Selected Contents: Introduction to Biotechnology Operations: Planning for Success Project Management Regulatory Affairs Regulatory Compliance Quality Systems Biomanufacture Quality Control Nonclinical Studies Clinical Trials Glossary Additional Reading
Catalog no. K11486, March 2011, 416 pp. ISBN: 978-1-4398-3027-7, $99.95 / £63.99 Also available as an eBook
Practical Problems and Questions
For more information and complete contents, visit www.crcpress.com
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Industry Applications Intelligent Energy Field Manufacturing Interdisciplinary Process Innovations Edited by
Wenwu Zhang GE Global Research Center, Schenectady, New York, USA
An in-depth introduction to Intelligent Energy Field Manufacturing (EFM), this book explores a fresh engineering methodology that not only integrates but also goes beyond methodologies such as Design for Six Sigma, Lean Manufacturing, Concurrent Engineering, selfassembly, biometics, and more. It discusses dynamic M-PIE flows, the generalities of energy fields, logic functional materials and intelligence, the open scheme of intelligent EFM implementation, and the principles of intelligent EFM. The book takes a highly interdisciplinary approach that includes research frontiers such as micro/nano fabrication, high strain rate processes, and laser shock forming, to name just a few.
Features: • Establishes the New Standard of Engineering Optimization that considers short-term benefits as well as long-term interests of an organization
Reverse Engineering Technology of Reinvention Wego Wang University of Massachusetts, Lowell, USA
“The topic of this book represents an important technological field that has heretofore been ignored by academics, despite being well accepted in industry. I am delighted by its publication.” —Professor Lavernia, Dean of Engineering at UC Davis
Written to advance the technology of reinvention and improve the competitiveness of commercial parts in the aftermarket, this volume discusses the proper measuring and analyses required to reproduce or repair an Original Equipment Manufacturer (OEM) part using modern reverse engineering technologies, as well as regulations that govern the practice. Offering numerous real-world examples, the book enables readers to determine if a duplicated or repaired part can meet the design functionality of the original. Going beyond industrial manufacturing, the book also looks at the use of reverse engineering in academic research and legal and forensic analyses.
• Supplies high-level methodological reviews of process innovations in important engineering directions
Features:
• Includes interdisciplinary process innovations with a focus on the artful manipulation of energy flows
• Focuses on how to analyze the relevant properties for materials identification, and the necessary data required for manufacturing process verification
• Discusses high-level integration of information/ intelligence flow into manufacturing • Explores future directions of intelligent EFM Catalog no. 71017, August 2010, 728 pp. ISBN: 978-1-4200-7101-6, $149.95 / £95.00 Also available as an eBook
• Aids readers in evaluating the feasibility of a reverse engineering proposal or project
• Explains statistical applications in data processing as they relate to reverse engineering • Cites legal precedents on intellectual property and proprietary data, and discusses their effects on reverse engineering practice Catalog no. K10314, September 2010, 357 pp. ISBN: 978-1-4398-0630-2, $139.95 / £89.00 Also available as an eBook
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New & Essential Books in Biotechnology from CRC Press
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Industry Applications New!
Distillation Control, Optimization, and Tuning
Healthcare Biotechnology
Fundamentals and Strategies
Dimitris Dogramatzis
Lanny Robbins Larco Technologies LLC
With a focus on the fundamentals and strategies of distillation columns, this book covers the process variables for continuous distillation columns, as well as four basic control strategies and the typical cases in which they are used. The author defines the inlet and outlet streams and process variables for a distillation column and then explains the overall concept of the separation and purification that is performed. Performance and product quality are described in terms of specification requirements, and tools and techniques for the optimization of quality performance are provided. Figures and graphs are included to illustrate concepts.
Selected Contents: Introduction and Overview
A Practical Guide Dogramatzis Pharmacy, Athens, Greece
Focusing on the management of health-care related biotechnology, this text is a practical guide assisting all healthcare related biotech professionals in their day-to-day activities. It contains chapters on bioeconomy, biolicensing, biofinance, biopartnering, biodrug research, biomarket planning, biopromotion, product life cycle management, and biobusiness models. Written by a well-established professional and registered pharmacist, this reference is appropriate for graduate students and industry professionals. It contains over 350 tables and figures, and end-of-section problems and extensive references accompany each chapter.
Selected Contents: THE HEALTHCARE BIOTECHNOLOGY INDUSTRY: Bioeconomy.
Distillation Control Variables
INTELLECTUAL PROPERTY: Intellectual Property Management. Biolicensing.
Separation Power
FUNDING: Biofinance. Biopartnering.
Distillate/Feed Material Balance Split
NEW PRODUCT DEVELOPMENT: Biodrug Research. Biomanufacturing.
Distillation Control Strategies Constraints Optimizing Product Quality Performance PID Feedback Control Loop Closed Loop Tuning of Controllers Open Loop Testing of Process Response Appendix Catalog no. K12689, April 2011, 144 pp. ISBN: 978-1-4398-5748-9, $149.95 / ÂŁ95.00 Also available as an eBook
MARKETING: Biomarketing planning. Biopromotion. Biopricing. Biosupply Chain. Product Life Cycle Management. RUNNING THE BUSINESS: Biobusiness models. Biosimilars Model. Biocompany Life Cycle. Catalog no. K12108, December 2010, 689 pp. ISBN: 978-1-4398-4746-6, $99.95 / ÂŁ63.99 Also available as an eBook
For more information and complete contents, visit www.crcpress.com
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New Edition of a Bestseller from
Mark J. Madou! Third Edition, Three-Volume Set Marc J. Madou University of California, Irvine, USA
Buy the Set and Save! Catalog no. 3180, July 2011, 1992 pp., ISBN: 978-0-8493-3180-0 $249.95 / £159.00
Also available as individual volumes Volume I Selected Contents: Historical Note. Crystallography. Quantum Mechanics and the Band Theory of Solids. Silicon Single Crystal is Still King. Photonics. Fluidics. Electrochemical and Optical Analytical Techniques.
Catalog no. 55119, July 2011, 656 pp. ISBN: 978-1-4200-5511-5, $99.95 / £63.99 Volume II Selected Contents: From Traditional Manufacturing to Nanotechnology. Scaling Laws, Actuators, and Power and Brains in Miniature Devices. Miniaturization Application.
Catalog no. 5516X, July 2011, 650 pp. ISBN: 978-1-4200-5516-0, $99.95 / £63.99 Volume III Selected Contents: Lithography. Pattern Transfer with Subtractive Techniques. Pattern Transfer with Additive Techniques.
Catalog no. 55194, July 2011, 670 pp. ISBN: 978-1-4200-5519-1, $99.95 / £63.99 Ancillary materials are available upon qualifying course adoption.
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