Book Review: Handbook of Chemistry and Physics, 91st Ed.

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Book Review of CRC Handbook of Chemistry and Physics. gIst Edition - Journal of Medicinal Chemistry (ACS Publications)

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Medicinal Chemistry J. Med. Chern.

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DeSign, SynthesiS, and Evaluation of Dlbenzo[c,11 ][1.6]naphthyrtdlnes as Topoisomera5e I Inhibitors and Potential Anticancer Agents

Book Review of CRC Handbook of Chemistry and Physics. 91st Edition J. Keith Guillory College of Pharmacy The University of Iowa Iowa City, Iowa 52242, United States E-mail: keith-guillory @ujQwa.edu

J. Med. Chern., 2010, 53 (24), P 8780 001: 10.lD21/jm101422n Publication Date (Web): November 23, 2010 Copyright Ii:) 2010 American Chemical Society

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O!.~ponURL Weighing 7.4 pounds, this edition has 194 fewer pages than the previous edition, and its price is the same, so it is still a bargain for those who insist on having the latest tables of data. The 2011 CD-ROM edition ($169.95) was published in August and is somewhat more convenient to search than the print version. At my institution the 91 st edition of the Handbook is accessible online.

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Research Topic For medicinal chemists who purchased the 90th print edition, there are few new sections that will be of interest. The section on physical constants of organic compounds contains exactly the E§'!'!I~!YQ"K~~~.:.::::::..~=3J same number of entries (10877) as in the 90th edition, and the section on structure and (Search) function of common drugs also is identical (107 entries). Some of the figures in the tables of bond dissociation energies, electron affinities, and atomic and molecular polarizabilities have History been updated. Tables of the thermophysical properties of organic compounds have been ---·----·-·-·.-----··--·-·-····1 Published In Issue validated through the cooperation of the Thermodynamics Research Center of the National December 23, 2010 ····..···..··............ ·_······ ....······ .. ·········1 Institute of Standards and Technology. There are new tables of abbreviations in the area of Article ASAP Ii polymer science (two pages), and physical properties of 20 polymers are tabulated (two pages). _ November 23, 2~~___ ---.l Unfortunately, in order to keep the text "portable", the indices of Chemical Abstracts registry numbers for organic and for inorganic compounds have been deleted. These are, however, available in the electronic versions of the Handbook.

J. Keith Guillory

Every chemist will have occasion to refer to this text from time to time, but I cannot necessarily recommend updating it for one's personal library each year.

CRC Handbook of Chemistry and Physics. 91st Editio·n. Edited by W. M. Haynes CRC Press (Taylor and FranCis Group), Boca Raton, FL. 2010. xi +2610 pp. 22 x 29 cm. ISBN 978-1-4398-2077-3. $149.95.

Copyright ~ 2011 Amorican Chornical Society 1155 Sixteenth St,.ootl~.W., W.ollington, DC 20036

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http://pubs.acs.org/doi/full/ 10.1D21/Jm 101422n

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