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Contents Rehabilitation ..............................................................3 Bio Systems ............................................................4 Biomedical Engineering..........................................7 Imaging................................................................17 Nanotechnology ..................................................27 Page 7
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Neuroscience........................................................31 Sensors & Signals ................................................32 BioMems ..............................................................36
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Rehabilitation Multiple Sclerosis Rehabilitation
Paediatric Rehabilitation Engineering
From Impairment to Participation
From Disability to Possibility
Edited by
Edited by
Marcia Finlayson
Tom Chau
University of Illinois at Chicago, USA
Bloorview Kids Rehab, Toronto, Ontario, Canada
A comprehensive resource designed to inform and guide health and rehabilitation practitioners, Multiple Sclerosis Rehabilitation: From Impairment to Participation provides a broad-based perspective on multiple sclerosis (MS). It examines how the disease influences everyday life and discusses the strategies that can be employed by rehabilitation practitioners to enable people with MS to fully engage in life. The first section offers an overview of MS basics. The next two sections describe MS rehabilitation, how impairments can best be managed, and methods for enhancing activity and participation among people with MS. The final section discusses contextual factors that may influence MS rehabilitation efforts. The book uses the International Classification of Functioning, Disability, and Health as an organizing structure and features contributions from some of the world’s top experts in MS rehabilitation.
Jillian Fairley Toronto, Ontario, Canada
Offering international perspectives, this book provides an up-to-date synopsis of research advances in pediatric rehabilitation engineering. Each chapter details a particular area of technology or those developments of significant clinical relevance to pediatric rehabilitation. Each chapter also includes a conceptual description of the technology or underlying scientific principles, followed by a synthesis of relevant literature, recent discoveries, selected clinical case studies (where applicable), and perspectives for future directions. Ample references facilitate further study.
Catalog no. K10416, December 2010, 366 pp. ISBN: 978-1-4398-0842-9, $145.95 / £93.00
Contents: Foundations: Introduction. Multiple Sclerosis Basics. Stories to Inform the Art of Rehabilitation Practice. An Overview of Multiple Sclerosis Rehabilitation. Multiple Sclerosis Rehabilitation for Impairments in Body Structure and Function: Fatigue. Balance Disorders. Muscle Strength, Tone, and Coordination. Cognition. Chronic Pain. Depression. Visual Impairments. Multiple Sclerosis Rehabilitation for Activity Limitations and Participation Restrictions: Communication. Mobility. Self-Care. Domestic Life. Employment. Physical Activity and Leisure. The Influence of Personal and Environmental Context on Multiple Sclerosis and Multiple Sclerosis Rehabilitation: Influences of Age and Sex. Other Health Concerns. Coping. Physical Environment. Caregiving. Cultural Considerations. Moving into the Future: Optimizing Rehabilitation Experiences.
Catalog no. K11417, August 2012, c. 596 pp. ISBN: 978-1-4398-2884-7, $149.95 / £95.00 Also available as an eBook
An Introduction to Rehabilitation Engineering Edited by
Rory A Cooper, Hisaichi Ohnabe, and Douglas A. Hobson University of Pittsburgh, Pennsylvania, USA
"Finally, a text that allows engineers and graduate students from other healthcare professions to understand and appreciate just how vast and exciting the contributions of rehabilitation engineering and assistive technology can be for people with disabilities. This text is perfect not only for engineering students but also for physical therapists and other professionals who want to know the science behind assistive technology. … offers wonderfully straightforward insights into the very complex world of rehabilitation engineering. … blueprints for understanding the language, process, and science behind the product development associated with assistive technology.” —Robert Gailey, University of Miami Miller School of Medicine, Florida, USA
Catalog no. IP834, December 2006, 472 pp. ISBN: 978-0-8493-7222-3, $81.95 / £52.99
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3
Bio Systems
Feedback Control in Systems Biology
Biofluid Mechanics The Human Circulation, Second Edition Krishnan B. Chandran
Carlo Cosentino University of Catanzaro, Italy
Declan Bates
University of Iowa, Iowa City, USA
Ajit P. Yoganathan
University of Exeter, UK
"... sets out the powerful engineering perspective on biological systems in all of its glory. Comprehensive, thoughtful and accessible, this is one of the best books in the field." —Professor Michael Stumpf, Division of Molecular Biosciences, Imperial College London
"This is an excellent book which will be enjoyed by biologists and theoreticians alike. The authors skillfully combine key concepts from control theory with real cases studies in order to show how the theory can be used both to study and to gain insight into biological networks." —Professor Helen Byrne, Centre for Collaborative Applied Mathematics, University of Oxford
"Cosentino and Bates address one of the great educational challenges for systems biology—namely the inaccessibility of control theory to life scientists. As so many researchers have demonstrated, control theory has profound relevance for the study of biophysical systems, but Cosentino and Bates are the first to address this topic in a self-contained manner for the uninitiated. This book is an essential resource for life scientists interested in the principles of feedback control and nonlinear dynamics." —Professor Frank Doyle, Department of Chemical Engineering, University of California at Santa Barbara
"Systems biology is an inherently interdisciplinary endeavor, and Cosentino and Bates seamlessly interweave these perspectives into an engaging and comprehensive text that is equally accessible to biologists, computational scientists, and engineers. Through their detailed examination of case studies, the authors develop a general conceptual framework for using quantitative analysis to better understand biological systems. This book is an excellent introduction for researchers new to the field, and it provides compelling and contemporary content for engineering courses on dynamics and control." —Professor Joshua Leonard, Department of Chemical and Biological Engineering, Northwestern University
Georgia Institute of Technology, Atlanta, USA
Stanley E. Rittgers University of Akron, Ohio, USA
"... provides a good platform in fluid mechanics prior to progressing to the physiological applications, which make it an appropriate textbook for BME students." —Professor Tim McGloughlin, Centre for Applied Biomedical Engineering Research and Department of Mechanical Aeronautical and Biomedical Engineering, University of Limerick
Designed for senior undergraduate or first-year graduate students in biomedical engineering, Biofluid Mechanics: The Human Circulation, Second Edition teaches students how fluid mechanics is applied to the study of the human circulatory system. Reflecting changes in the field since the publication of its predecessor, this second edition has been extensively revised and updated.
New to the Second Edition: • Improved figures and additional examples • More problems at the end of each chapter • A chapter on the computational fluid dynamic analysis of the human circulation, which reflects the rapidly increasing use of computational simulations in research and clinical arenas Drawing on the authors’ experience teaching courses on cardiovascular fluid mechanics, the book begins with introductory material on fluid and solid mechanics as well as a review of cardiovascular physiology pertinent to the topics covered in subsequent chapters. The authors then discuss fluid mechanics in the human circulation, primarily applied to blood flow at the arterial level. They also cover vascular implants, measurements in the cardiovascular system, and various considerations and approaches involved in the computational modeling of cardiovascular diseases and therapies.
Catalog no. K12006, February 2012, 451 pp. ISBN: 978-1-4398-4516-5, $104.95 / £66.99 Also available as an eBook
Catalog no. K10870, October 2011, 296 pp. ISBN: 978-1-4398-1690-5, $89.95 / £57.99 Also available as an eBook
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Bio Systems
Nature-Based Innovation
Dynamics of Biological Systems
Yoseph Bar-Cohen
Michael Small
JPL/Caltech, Pasadena, California, USA
Hong Kong Polytechnic University, Kowloon
Humans have always looked to nature’s inventions as a source of inspiration. The observation of flying birds and insects leads to innovations in aeronautics. Collision avoidance sensors mimic the whiskers of rodents. Optimization algorithms are based on survival of the fittest, the seed-picking process of pigeons, or the behavior of ant colonies. In recent years, these efforts have become more intense, with researchers seeking rules, concepts, and principles of biology to inspire new possibilities in materials, mechanisms, algorithms, and fabrication processes. A review of the current state of the art, Biomimetics: Nature Based Innovation documents key biological solutions that provide a model for innovations in engineering and science.
With exercises and projects in each chapter, this classroom-tested text shows how to apply a variety of mathematical and computational techniques to model and analyze the temporal and spatial phenomena of biological systems. Presenting a wide range of models—from ECG signal processing to pandemic modelling to population dynamics—the book requires no advanced knowledge of mathematics. The mathematical models and computer simulations offer insight into cardiac pacemakers, artificial electrical defibrillation, pandemics, pattern formation, flocking behavior, the interaction of autonomous agents, and hierarchical and structured network topologies. MATLAB® implementations of algorithms and case studies are available on the author’s website.
With contributions from leading experts, the book explores a wide range of applications of biomimetics across a variety of fields. Offering myriad examples of technologies inspired by biology, the book discusses artificial senses and organs; mimicry at the cell–materials interface; and modeling of plant cell wall architecture and tissue mechanics. It also covers biomimetic composites; artificial muscles; refreshable Braille displays; biomimetic optics; and the mimicking of flying birds, insects, and marine biology. A series of chapters examines applications of biomimetics in manufacturing, products, medicine, and robotics— including medical devices, implants, and the development of human-like robots. Contributors also explore biologically inspired design as a tool for interdisciplinary education and describe the biomimetic process in artistic creation. The final chapter outlines the challenges to biomimetic-related innovation and offers a vision for the future.
Catalog no. K12463, August 2011, 284 pp. ISBN: 978-1-4398-5336-8, $79.95 / £49.99
Biomimetics
A follow-up to Biomimetics: Biologically Inspired Technologies (2005), this comprehensive reference methodically surveys the latest advances in this rapidly emerging field. It features an abundance of illustrations, including a 32-page color insert, and provides extensive references for engineers and scientists interested in delving deeper into the study of biomimetics.
Catalog no. K11566, September 2011, 788 pp. ISBN: 978-1-4398-3476-3, $159.95 / £99.00 Also available as an eBook
Also available as an eBook
Biology for Engineers Arthur T. Johnson University of Maryland, College Park, USA
Introducing the field of biology to today’s engineering students, this entry-level text minimizes unnecessary memorization of connections and classifications and emphasizes concepts, technology, and the utilization of living things. Filled with practical examples, the book discusses biological responses from the perspectives of psychology, human factors, genetics, plant and animal physiology, imaging, control systems, actuary, and medicine. Offering numerous tables of useful information, it covers the scaling of biological responses and attributes as well as different types of applications related to biological systems.
Catalog no. 77635, September 2010, 775 pp. ISBN: 978-1-4200-7763-6, $104.95 / £66.99 Also available as an eBook
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5
Bio Systems Vibrational Spectroscopy for Tissue Analysis Ihtesham ur Rehman
Electromagnetic Fields in Biological Systems
The Kroto Research Institute, University of Sheffield, UK
Edited by
Zanyar Movasaghi
James C. Lin
Queen Mary University of London, UK
University of Illinois at Chicago, USA
Shazza Rehman
Spanning static fields to terahertz waves, this volume explores the range of consequences electromagnetic fields have on the human body. Topics discussed include essential interactions and field coupling phenomena, electric field interactions in cells, focusing on ultrashort, pulsed high-intensity fields, dosimetry or coupling of ELF fields into biological systems, and the historical developments and recent trends in numerical dosimetry. It also discusses mobile communication devices and the dosimetry of RF radiation into the human body, exposure and dosimetry associated with MRI and spectroscopy, and available data on the interaction of terahertz radiation with biological tissues, cells, organelles, and molecules.
St. George's Healthcare NHS Trust, West Yorkshire, UK
Presenting a variety of vibrational spectroscopic techniques, this volume focuses on Raman and Fourier transform infrared (FTIR) spectroscopy and their use in noninvasive optical tissue diagnosis. It covers the most recent research in this area to create a unique database of different chemical bands and their assignments of spectral bands. The text explores the spectroscopic investigation of different tissues and samples, including breast tissue, lung tissue, and brain tissue. Based on their years of experience with various applications, the authors provide definitions of peak frequencies as well as other aspects of spectroscopy that could be helpful to a wide range of scientists.
Catalog no. K11629, October 2012, c. 336 pp. ISBN: 978-1-4398-3608-8, $159.95 / £99.00
Catalog no. K12740, October 2011, 458 pp. ISBN: 978-1-4398-5999-5, $149.95 / £95.00 Also available as an eBook
Also available as an eBook
Quantitative Understanding of Biosystems An Introduction to Biophysics Thomas M. Nordlund University of Alabama at Birmingham, USA
Biologically Inspired Robotics Edited by
Yunhui Liu The Chinese University of Hong Kong, Shatin
Dong Sun City University of Hong Kong, Kowloon
“This book is so far the best on the market in terms of an undergraduate biophysics textbook.” —Liviu Movileanu, Syracuse University
“Particularly, it is nice how the book builds up toward the main equations to make them intuitive from basic principles.” —Diego Krapf, School of Biomedical Engineering, Colorado State University
“ [A] nice exposition on the differences between how a biologist approaches a problem and how a physicist does.” —Charles Wolgemuth, University of Connecticut Health Center
This reference contains cutting-edge material— considerably expanded and with additional analysis— from the 2009 IEEE International Conference on Robotics and Biomimetics. The 16 chapters cover biologically inspired robot design and control, micro/nano robots for bio-systems and biomedicine, biological measurement and actuation, and applications of robotics technology to biological problems. A state-of-the-art resource for graduate students and researchers in control engineering, robotics, and biomedical engineering, this text helps readers understand the technology and principles in this emerging field. It includes a wealth of illustrations and equations.
Catalog no. 89772, March 2011, 583 pp. ISBN: 978-1-4200-8972-1, $89.95 / £57.99
Catalog no. K12555, December 2011, 340 pp. ISBN: 978-1-4398-5488-4, $99.95 / £63.99
Also available as an eBook
Also available as an eBook
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Biomedical Engineering A Laboratory Course in Tissue Engineering Melissa Kurtis Micou University of California, San Diego, USA
Reliable Design of Medical Devices Third Edition
Dawn Kilkenny
Richard C. Fries
University of Toronto, Ontario, Canada
Isorel, Inc., Fitchburg, Wisconsin, USA
A Laboratory Course in Tissue Engineering is a hands-on lab manual for tissue engineering (TE) instruction. It contains classic TE experiments as well as modern TE techniques, emphasizing the importance of engineering analysis, mathematical modeling, and statistical design of experiments. The book includes over 20 stand-alone experiments that provide more than a semester's worth of activities, allowing instructors to customize their courses. The authors present experiments that use equipment commonly found in labs equipped for tissue culture, and they include pre-lab and discussion questions for each experiment. They describe multiple formats useful for the presentation of results, including technical posters, extended abstracts, and technical reports.
The medical device industry is constantly evolving and as a result, texts that explore the reliability of these devices must keep pace with changes. With an emphasis on safety and a thorough analysis of hazards and risks, Reliable Design of Medical Devices, Third Edition addresses changes in methodology and discusses the latest thinking on reliability. The book provides working engineers with assistance in preparing, designing, and testing a product. Discussions on hazard analysis and reliability tools such as FMEA and FTA offer direction in ensuring that the new device is safe and effective. Every chapter in this third edition has been completely updated and three new chapters have been added.
Contents: Getting Started in the Lab. Lab Safety. Essential Lab Skills for Tissue Engineers. Isolation of Primary Chondrocytes from Bovine Articular Cartilage. Measuring and Modeling Growth of a Cell Population. Purification of a Cell Population Using Magnetic Cell Sorting. Decellularized Matrices for Tissue Engineering. Effect of Plating Density on Cell Adhesion to Varied Culture Matrices. Dynamic vs. Static Seeding of Cells onto Biomaterial Scaffolds. Cell Patterning Using Microcontact Printing. Measuring and Modeling the Motility of a Cell Population Using an Under-Agarose Assay. Characterizing Matrix Remodeling Through Collagen Gel Contraction. Effect of Substrate Stiffness on Cell Differentiation. Effect of Culture Configuration (2D vs. 3D) on Matrix Accumulation. Combining in silico and in vitro Techniques to Engineer Pluripotent Stem Cell Fate. The Fahraeus-Lindqvist Effect: Using Microchannels to Observe Small Vessel Hemodynamics. Examining Single Cell Mechanics Using a Microfluidic Micropipette Aspiration System. Contribution of Tissue Composition to Bone Material Properties. Technical Communication: Presenting Your Findings. Appendices.
Contents: Basics of Reliability. Reliability. The Concept of Failure. Regulations And Standards. The FDA. Medical Device Directives. Quality System Regulation (QSR). Standards Directly Related to Reliability. Specifying The Device. The Medical Device as an Entity. Defining the Device. Requirements Engineering. Safety and Risk Management. Liability. Intellectual Property. Human Factors. Six Sigma. Hardware Design And Test. Hardware Design. Hardware Risk Analysis. Hardware V & V. Hardware Data Analysis. Software Design And Test. Software Design. Software Coding. Software Metrics. Software Risk Analysis. Software V & V. Software Data Analysis. Manufacturing. Hardware Manufacturing. Software Manufacturing. Configuration Management. Maintenance. Analysis of Field Data.
Catalog no. K14218, September 2012, c. 504 pp. ISBN: 978-1-4398-9491-0, $179.95 / ÂŁ114.00 Also available as an eBook
Catalog no. K13694, August 2012, 286 pp. Soft Cover ISBN: 978-1-4398-7893-4, $59.95 / ÂŁ38.99 Also available as an eBook
For more information and complete contents, visit www.crcpress.com
7
Biomedical Engineering Biomaterials Science Materials and Processes for Medical Devices Mel Schwartz Consultant, Clearwater, Florida, USA
Within the past five years there have been innovations and excellence applied to the state of the art in biomaterials science and engineering for medical devices used to repair, replace, and regenerate tissues and structures of the human body. Covering a variety of medical devices in use or currently in development, Materials and Processes for Medical Devices is written for students and professionals in materials science and biomedical engineering. It examines nanomaterials, composites, shape memory alloys, plastics, ceramics, and ferrous materials. It describes materials in use in various medical devices and their compatibility with the human body. It also explores material properties such as fatigue strength, hardness, and tensile strength. The book presents cutting-edge research in the fields of nanotechnology, material selection, and processing methods. It also profiles current and emerging fabrication technologies and software. Devices and materials currently used in the industry are described and explained by the developers who made them and several case histories are presented. The designs created and discussed in the book have reached the application stage and can impact thousands of people now and in the future.
Contents: Introduction Devices Stents Prosthetics, Orthopedics, Aesthetics Laser – Processes and Applications Tissue, Tissue Engineering, & Bone Growth & Loss Drug Delivery Sensors – Biosensors – Mems – Actuators Coatings Nanotechnology Stem Cells Materials --Processes – Fabrication
An Integrated Clinical and Engineering Approach Edited by
Yitzhak Rosen Superior NanoBioSystems, Silver Spring, Maryland, USA
Noel Elman Cambridge, Massachusetts, USA
"This book is essential when designing, developing and studying biomedical materials. … provides an excellent review—from a patient, disease, and even genetic point of view—of materials engineering for the biomedical field. I found very interesting facts about patient study combined with clinical study of materials. … offers interesting insight into biomedical engineering, where clinicians and engineers have to understand each other to provide specific solutions to the medical device field.” —Fanny Raisin-Dadre, BioInteractions Ltd., Berkshire, UK
Going far beyond the coverage in most standard books on the subject, Biomaterials Science: An Integrated Clinical and Engineering Approach offers a solid overview of the use of biomaterials in medical devices, drug delivery, and tissue engineering. Combining discussion of materials science and engineering perspectives with clinical aspects, this book emphasizes integration of clinical and engineering approaches. In particular, it explores various applications of biomaterials in a range of fields, including tissue engineering, neurosurgery, hemocompatibility, BioMEMS, nanoparticle-based drug delivery, dental implants, and obstetrics/gynecology. The book engages those engineers and physicians who are applying biomaterials at various levels to: • Increase the rate of successful deployment of biomaterials in humans • Lower the side effects of such a deployment in humans • Accumulate knowledge and experience for improving current methodologies • Incorporate information and understanding relevant to future challenges, such as permanent artificial organ transplants
What Does The Future Hold?
Presenting contributions from a variety of experts from both the clinical and engineering sides of the fields mentioned above, this book stands apart by emphasizing a need for integrating these two equally important arenas.
Catalog no. K11412, October 2012, c. 712 pp. ISBN: 978-1-4398-2875-5, $149.95 / £95.00
Catalog no. K10223, June 2012, 310 pp. ISBN: 978-1-4398-0404-9, $149.95 / £95.00
Also available as an eBook
Also available as an eBook
Robotics Imaging and NDT
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Biomedical Engineering New Edition of a Bestseller!
The Medical Device R&D Handbook Second Edition
Basic Transport Phenomena in Biomedical Engineering Third Edition Ronald L. Fournier
Edited by
University of Toledo, Ohio, USA
Theodore R. Kucklick TRKD Medical Devices, Los Gatos, California, USA
Praise for the First Edition: “This is the first in its class of multidisciplinary books for medical device innovators, reaching across several disciplines to capture what innovators need.” —Michael Gertner, MD, Co-Director, Surgical Innovation Program at Stanford University
“This is a resource that will help medical device innovators develop better products, and more focused companies, more quickly.” —Randy Williams, Founder, The Keiretsu Forum
“Finally, a real manual that for the first time supports efficient medical device development.” —Peter H. Muller, President, Interform Product Development
Due to tremendous technological advances in medical technology, the field of medical device design has grown in importance. The first edition of this volume grew to become the most popular resource in this category. This updated and expanded second edition presents practical advice and interviews from key opinion leaders and pioneers in the field. Specially designed for medical device designers, biomedical engineering students, physician entrepreneurs, and medical device entrepreneurs, The Medical Device R & D Handbook, Second Edition explains the basics on how to prototype and develop a medical device. Highlighting the latest FDA regulations, it discusses the fundamentals of plastics, adhesives, medical needles, and rapid prototyping and provides tips and tools to save time and money. Extensive references at the end of each chapter facilitate additional study.
Catalog no. K10598, December 2012, 440 pp. ISBN: 978-1-4398-1189-4, $139.95 / £89.00 Also available as an eBook
Encompassing a variety of engineering disciplines and life sciences, the very scope and breadth of biomedical engineering presents challenges to creating a concise, entry-level text that effectively introduces basic concepts without becoming overly specialized in subject matter or rarified in language. Basic Transport Phenomena in Biomedical Engineering, Third Edition meets and overcomes these challenges to provide readers with the foundational tools and the confidence they need to apply these techniques to problems of ever-greater complexity. Bringing together fundamental engineering and life science principles, this highly accessible text provides focused coverage of key momentum and mass transport concepts in biomedical engineering. It offers a basic review of units and dimensions and material balances and then emphasizes those chemical and physical transport processes that have applications in the development of artificial and bioartificial organs, controlled drug delivery systems, and tissue engineering. The book also includes a discussion of thermodynamic concepts and covers topics such as body fluids, osmosis and membrane filtration, physical and flow properties of blood, solute and oxygen transport, and pharmacokinetic analysis. It concludes with the application of these principles to extracorporeal devices as well as to tissue engineering and bioartificial organs. The book includes numerous examples with a discussion of the numerical methods used to solve the problems. It contains an extensive bibliography of the research literature that supports the material in the text, and supplies illustrations with problems at the end of each chapter to provide readers the opportunity to explore in greater detail the material covered. Written in a style friendly to all readers, this text provides a quantitative understanding of the underlying physical, chemical, and biological aspects of the topic.
Catalog no. K11304, August 2011, 483 pp. ISBN: 978-1-4398-2670-6, $89.95 / £44.99 Also available as an eBook
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9
Biomedical Engineering Introduction to Biomedical Engineering Technology Second Edition
Edited by
Andrew W. Wood
Laurence J. Street
Swinburne University of Technology, Hawthorn, Victoria, Australia
Rosedale, British Colombia, Canada
While there are differences in design from one medical device to another, the principles of operation and, more importantly, the physiological and anatomical characteristics on which they operate are universal. Introduction to Biomedical Engineering Technology, Second Edition explains the uses and applications of medical technology and the principles of medical equipment management. The book describes the technological devices, various hardware, tools, and test equipment used in today’s healthcare arena. Photographs of representative equipment; the technical, physiological, and anatomical basis for their function; and where they are commonly found in hospitals are detailed for a wide range of biomedical devices—from defibrillators to electrosurgery units. This accessible text supplies an essential overview of clinical equipment and the devices for diagnostic or treatment purposes. The author’s practical approach and organization outlines everyday functions and applications of the various medical devices, preparing students for situations they will encounter on the job.
Features: • Incorporates real-life examples of the work of biomedical engineering technologists • Contains examples, illustrations, and end-ofchapter questions to test assimilation • Provides appendices with normal medical values, a list of regulatory bodies, Internet resources, and information on training programs • Includes a 16-page grayscale insert with photographs of real-life equipment problems Solutions manual available with qualifying course adoption
Catalog no. K12781, October 2011, 391 pp. ISBN: 978-1-4398-6058-8, $89.95 / £56.99 Also available as an eBook
Physiology, Biophysics, and Biomedical Engineering
Physiology, Biophysics and Biomedical Engineering provides a multidisciplinary understanding of biological phenomena and the instrumentation for monitoring these phenomena. It covers electricity, pressure, and flow along with the adaptation of physics to the special conditions and constraints of biological systems. While the text focuses on human biological systems, some of the principles also apply to plants, bacteria, and other animals. The first section of the book presents a general introduction to physiological systems and describes specialized methods used to record electrical events from biological tissue. The next part examines molecules involved in cell transport and signaling as well as the proteins relevant in cells’ ability to contract and generate tension. The text goes on to cover the properties of the heart, blood, and circulation and the monitoring of cardiac and circulatory function. It then discusses the interrelationship of pressures and flows in organ systems such as the lungs and kidneys and details the organization and function of the nervous system. After focusing on the systems used to monitor signals, the book explores modeling, biomechanics, and emerging technologies, including the progressive miniaturization of sensors and actuators in biomedical engineering.
Features: • Offers a multidisciplinary approach to human biological systems • Highlights the application of physics and engineering methods to medicine and biology • Gives students a solid basis for understanding the physiological processes in the human body • Draws on the classroom material of experienced lecturers • Incorporates a range of numerical problems with worked solutions Solutions manual available with qualifying course adoption
Catalog no. C6513, February 2012, 782 pp. ISBN: 978-1-4200-6513-8, $99.95 / £49.99 Also available as an eBook
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Biomedical Engineering
An Introduction to Biomaterials
Biomedical Engineering Principles
Second Edition
Second Edition
Edited by
Arthur B. Ritter, Vikki Hazelwood, Antonio Valdevit, and Alfred Ascione
Jeffrey O. Hollinger Carnegie Mellon University, Pittsburgh, Pennsylvania, USA
A practical road map to the key families of biomaterials and their potential applications in clinical therapeutics, Introduction to Biomaterials, Second Edition follows the entire path of development from theory to lab to practical application. It highlights new biocompatibility issues, metrics, and statistics as well as new legislation for intellectual property. Divided into four sections (Biology, Biomechanics, Biomaterials Interactions; Biomaterials Testing, Statistics, Regulatory Considerations, Intellectual Property; Biomaterials Compositions; and Biomaterials Applications), this edition includes both new and revised chapters on cells, tissues, and signaling molecules in wound healing cascades, as well as two revised chapters on standardized materials testing with in vitro and in vivo paradigms consistent with regulatory guidelines. Emphasizing biocompatibility at the biomaterial-host interface, it investigates cellcell interactions, cell-signaling and the inflammatory and complement cascades, specific interactions of protein-adsorbed materials, and other inherent biological constraints, including solid-liquid interfaces, diffusion, and protein types. Unique in its inclusion of the practicalities of biomaterials as an industry, the book also covers the basic principles of statistics, new US FDA information on the biomaterials-biology issues relevant to patent applications, and considerations of intellectual property and patent disclosure. This comprehensive, yet manageable work is an invaluable desk reference and instructional text for undergraduates.
Features: • Presents nine new chapters and 24 chapters extensively updated and revised with new accomplishments and contemporary data • Explains in vitro and in vivo testing paradigms and provides numerous examples in the chapters on experimental design, laboratory assays, and animal models • Contains end-of-chapter questions and answers • Includes extensive references for further study
Catalog no. K10637, November 2011, 644 pp. ISBN: 978-1-4398-1256-3, $119.95 / £48.99 Also available as an eBook
“ … not only an in-breadth overview on current BME fields, but also an in-depth analysis of specific selected topics that are supported by appropriate mathematical models, equations, quantitative data charts, and tables." —Biomedical Engineering Online
" … an excellent textbook for a class." —IEEE Engineering in Medicine and Biology Magazine
" … well-illustrated with figures, schemes, various plots, and mathematical equations." —G. Ya. Wiederschain, Doctor of Biological Science, Moscow State University, Russia
Biomedical Engineering Principles, Second Edition provides a solid, accessible grounding to this rapidly advancing field. Acknowledging the vast range of backgrounds from which the biomedical field draws, the book’s organization lends itself to a tailored course specific to the experience and interests of the student. The book begins with systems physiology, transport processes, cell physiology, and the cardiovascular system. Part I covers systems analysis, biological data, and modeling and simulation in experimental design. Part II presents biomedical signal processing, reviewing frequency, periodic functions, and Fourier series as well as signal acquisition and processing techniques. Part III discusses practical applications of biomechanics, focusing on the mechanical and structural properties of bone, musculoskeletal, and connective tissue with respect to joint range, load bearing capacity, and electrical stimulation. The final part highlights capstone design, explaining design perspectives for living and nonliving systems, the role of the FDA, and the project timeline from inception to proof of concept.
Features: • Includes new chapters on capstone design in biomedical engineering and entrepreneurship • Contains new coverage of systems biology and computational biology • Provides revised and updated chapters on the emerging field of tissue engineering • Offers extensive examples and in-chapter problems Solutions manual and figure slides are available upon qualifying course adoption
Catalog no. K10621, May 2011, 540 pp. ISBN: 978-1-4398-1232-7, $99.95 / £63.99 Also available as an eBook
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Biomedical Engineering Red Blood Cell Aggregation Oguz Baskurt Koc University, Turkey
Björn Neu Nanyang Technology University, Singapore
Herbert J. Meiselman University of Southern California, Los Angeles, USA
Red blood cells in humans and most other mammals have a tendency to form aggregates with a characteristic face-to-face morphology—similar to a stack of coins. Known as rouleaux, these aggregates are a normally occurring phenomenon and have a major impact on blood rheology. What is the underlying mechanism that produces this pattern? Does this really happen in blood circulation? And do these rouleaux formations have a useful function? The first book to offer a comprehensive review of the subject, Red Blood Cell Aggregation tackles these and other questions related to red blood cell (RBC) aggregates. The book covers basic, clinical, and physiological aspects of this important biophysical phenomenon and integrates these areas with concepts in bioengineering. It brings together state-of-the-art research on the determinants, mechanisms, measurement, and effects of RBC aggregation as well as on variations and comparative aspects. After an introductory overview, the book outlines factors and conditions that affect RBC aggregation. It presents the two hypotheses—the bridging model and the depletion model—that provide potential mechanisms for the adhesive forces that lead to the regular packing of the cells in rouleaux formations. The book also reviews the methods used to quantify RBC aggregation in vitro, focusing on their importance in clinical practice. Chapters discuss the effect of RBC aggregation on the in vitro rheology of blood as well as on tube flow. The book also looks at what happens in the circulation when red blood cells aggregate and examines variations due to physiological and pathophysiological challenges. The concluding chapter explores the formation of red blood cell aggregates in other mammals. Written by leading researchers in the field, this is an invaluable resource for basic science, medical, and clinical researchers; graduate students; and clinicians interested in mammalian red blood cells.
Mechanobiology Handbook Edited by
Jiro Nagatomi Clemson University, South Carolina, USA
Mechanobiology—the study of the effects of mechanical environments on the biological processes of cells—has evolved from traditional biomechanics via the incorporation of strong elements of molecular and cell biology. Currently, a broad range of organ systems are being studied by surgeons, physicians, basic scientists, and engineers. These mechanobiologists aim to create new therapies and further biological understanding by quantifying the mechanical environment of cells and the molecular mechanisms of mechanically induced pathological conditions. To achieve these goals, investigators must be familiar with both the basic concepts of mechanics and the modern tools of cellular/molecular biology. Unfortunately, current literature contains numerous studies that misuse standard mechanical estimations and terminology, or fail to implement appropriate molecular analyses. The Mechanobiology Handbook not only presents cutting-edge research findings across various fields and organ systems, but also provides the elementary chapters on mechanics and molecular analysis techniques to encourage cross-field understanding and appropriate planning. Aided by the continuous advancement of research tools in both mechanics and biology, more sophisticated experiments and analyses are possible—thus fueling the growth of the field of mechanobiology. Considering the complexity of the mechanics and the biology of the human body, most of the world of biomechanics remains to be studied. Since the field is still developing, this volume does not limit itself to one unified theory, but brings out many different viewpoints and approaches to stimulate further research and experiment.
Catalog no. 91212, March 2011, 563 pp. ISBN: 978-1-4200-9121-2, $169.95 / £109.00 Also available as an eBook
Catalog no. K11945, September 2011, 318 pp. ISBN: 978-1-4398-4180-8, $119.95 / £82.00 Also available as an eBook
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Biomedical Engineering Biomechanics of the Upper Limbs Mechanics, Modeling and Musculoskeletal Injuries, Second Edition Andris Freivalds The Pennsylvania State University, University Park, USA
Advances in Therapeutic Engineering Edited by
Wenwei Yue, Subhagata Chattopadhyay, Teik-Cheng Lim, and Rajendra Acharya
Over the past two decades, the growth in computerrelated jobs has led to a considerable increase in the number of work-related musculoskeletal disorders in the upper limbs. Now in its second edition, this comprehensive text is expanded to include recent findings regarding job stressors and a variety of ergonomic solutions. It provides up-to-date research on the biomechanics of the upper limbs and the mechanics of neuromuscular systems. The book covers risk factors for various disorders and tools used to identify their causes.
This comprehensive, edited book brings together topics in therapeutic and rehabilitative engineering— ranging from prosthetics to sensory substitution and medical robotics. Drawing on the expertise of a multidisciplinary field of contributors, it discusses both diagnostic and therapeutic aspects of healthcare and rehabilitation, including healthcare informatics, biomedical signal processing, sensors, and robotic prosthetics. Presenting a system-level approach to therapeutic engineering, it explores the current state and future directions of this rapidly advancing and cutting-edge field.
Catalog no. 91190, February 2011, 564 pp. ISBN: 978-1-4200-9119-9, $119.95 / £76.99
Catalog no. K13287, December 2012, c. 456 pp. ISBN: 978-1-4398-7173-7, $179.95 / £109.00
Also available as an eBook
Also available as an eBook
Biomedical Microsystems
The Physiology of Bioelectricity in Development, Tissue Regeneration, and Cancer
Ellis Meng
Edited by
University of Southern California, Los Angeles, USA
Written by an active researcher named one of Technology Review’s Young Innovators Under 35, this book begins with an introduction to the benefits of miniaturization. It introduces materials, fabrication technology, and the necessary components of all bioMEMS. The author covers fundamental principles and building blocks, including microfluidic concepts, lab-on-a-chip systems, and sensing and detection methods. The final chapters explore several important applications of bioMEMS, such as microdialysis, catheter-based sensors, MEMS implants, neural probes, and tissue engineering. Detailed examples, exercises, and illustrations help clarify the concepts.
Catalog no. 51229, September 2010, 408 pp. ISBN: 978-1-4200-5122-3, $94.95 / £59.99 Also available as an eBook
Christine E. Pullar University of Leicester, UK
Research indicates that electric fields play a role in initiating and coordinating complex regenerative responses in development and wound repair. They may also have a part in cancer progression and metastasis. Compiling current research in this rapidly expanding field, this text highlights relevant, cuttingedge topics poised to drive the next generation of medical breakthroughs. The book addresses bioelectricity’s roles in guiding cell behavior during morphogenesis and orchestrating higher order patterning. It also covers the response of stem cells to applied electric fields, which reveals bioelectricity as an exciting new player in tissue engineering and regenerative medicine.
Catalog no. K11686, March 2011, 342 pp. ISBN: 978-1-4398-3723-8, $119.95 / £76.99 Also available as an eBook
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Biomedical Engineering Advanced Electroporation Techniques in Biology and Medicine
Handbook of Biomedical Optics Edited by
David A. Boas Harvard Medical School, Charlestown, Massachusetts, USA
Constantinos Pitris University of Cyprus, Nicosia
Andrei G. Pakhomov Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, Virginia, USA
Damijan Miklavcic University of Ljubliana, Slovenia
Nimmi Ramanujam Duke University, Durham, North Carolina, USA
Marko S. Markov
Taking a broad yet detailed approach, this comprehensive handbook covers light-based diagnostic methodologies and light-mediated therapeutics as well as concepts and cutting-edge optical methods used in research and practice. Extensively illustrated, the book presents the theory and fundamentals along with stateof-the-art applications. The expert contributors also discuss advantages and disadvantages of various techniques. After introducing the background principles of optics, light sources, irradiation, and basic tissue optics concepts, the book focuses on spectroscopic methods, tomographic imaging, microscopic imaging methods, molecular probe development, and phototherapy.
During the last several decades, intense study has taken place on the effects of electromagnetic fields on living tissues. Reflecting this inquiry, this book discusses the theoretical and experimental evidence of these electromagnetic fields and electric pulses and examines their importance in medicine and biology. The authors present the basic techniques applied in electroporation and the advanced methods for creation of nanopores— highlighting their basic science and clinical applications. Topics include nano electroporation, classic electroporation, experimental evidence for electroporation of living cells, and electroporation for cancer and wound healing.
Williamsville, New York, USA
Catalog no. 90364, June 2011, 831 pp. ISBN: 978-1-4200-9036-9, $149.95 / £95.00
Catalog no. K11005, June 2010, 528 pp. ISBN: 978-1-4398-1906-7, $145.95 / £93.00
Also available as an eBook
Also available as an eBook
Advanced Biophotonics
Practical Biomedical Signal Analysis Using MATLAB®
Tissue Optical Sectioning Edited by
Ruikang K. Wang University of Washington, Seattle, USA
Katarzyn J. Blinowska and Jaroslaw Zygierewicz
Valery V. Tuchin Saratov State University, Russia
A survey of both basic and advanced optical imaging techniques, this reference provides an overview of optical imaging and manipulation technologies in biophotonics. It reviews the principles and fundamentals of bioimaging and molecular imaging and manipulation techniques. It also presents an overview of instrumentation, basic algorithms, and data processing methods. Accessible to students and researchers, the book discusses a range of application areas, including established and newer methodologies in biotechnology, biomedical engineering, biophysics, medicine, and pharmacology.
Catalog no. K14253, December 2012, c. 576 pp. ISBN: 978-1-4398-9581-8, $199.95 / £127.00 Also available as an eBook
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University of Warsaw, Poland
A solid treatment of various signal processing methods and applications, this volume also offers hands-on guidance on which methods are appropriate for a given task and different types of data. The first several chapters of the text describe signal analysis techniques—including the newest and most advanced methods—in an easy and accessible way. MATLAB® routines are listed and freely available software is discussed where appropriate. The final chapter explores the application of the methods to a broad range of biomedical signals, highlighting problems encountered in practice.
Catalog no. K10605, September 2011, 324 pp. ISBN: 978-1-4398-1202-0, $99.95 / £63.99 Also available as an eBook
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Biomedical Engineering
Introduction to Complexity and Complex Systems Robert B. Northrop University of Connecticut, Storrs, USA
Written for students and professionals in the fields of biomedical engineering, systems biology, biophysics, and physiology, this unique reference covers complexity issues within living systems. Topics include human responses to coping with complex systems, the Law of Unintended Consequences, the relation of complexity to evolution, the complexity inherent in invertebrate immune systems, and the complexity inherent in economic systems. A comprehensive glossary provides acronyms and terms relating to complex, nonlinear biological systems. Dynamic models and homework questions are also included to further aid in understanding.
Catalog no. K11775, December 2010, 551 pp. ISBN: 978-1-4398-3901-0, $83.95 / £53.99 Also available as an eBook
Digital Microfluidic Biochips Design Automation and Optimization Krishnendu Chakrabarty Duke University, Durham, North Carolina, USA
Tao Xu Cisco Systems, Cary, North Carolina, USA
Microfluidics-based biochips combine electronics with biochemistry for emerging application areas such as point-of-care medical diagnostics, on-chip DNA analysis, automated drug discovery, and protein crystallization. This book envisions an automated design flow for microfluidic biochips. It offers automation solutions for problems unique to digital microfluidics. The authors provide a comprehensive methodology for the automated design, test, and use of robust and low-cost manufactured digital microfluidic systems. Using real-life bioassays as examples, they offer a comprehensive set of practical methodologies and tools for chip design and manufacture.
Catalog no. K11010, May 2010, 213 pp. ISBN: 978-1-4398-1915-9, $145.95 / £93.00
Basic Introduction to Bioelectromagnetics Second Edition Cynthia Furse, Douglas A. Christensen, and Carl H. Durney University of Utah, Salt Lake City, USA
This revised and updated edition facilitates the process of interdisciplinary research by introducing life scientists to the basic concepts of electromagnetic fields (EM). The book outlines elements of EM that are helpful to life scientists working with physicists and electrical engineers. Each concept is presented with an associated application and discussion. Example applications include MRI, NMR, ultrasound, neural stimulation, and cardiac pacing/defibrillation. With the liberal use of diagrams and graphs, this text covers the entire frequency spectrum through optical frequencies from a qualitative perspective beneficial to life scientists.
Catalog no. 55429, March 2009, 288 pp. ISBN: 978-1-4200-5542-9, $107.95 / £69.99 Also available as an eBook
Tunable Laser Applications Second Edition Edited by
F. J. Duarte Interferometric Optics, Rochester, New York, USA
With an emphasis on biological and medical applications, the second edition of this essential reference reflects the significant developments in tunable lasers and their applications that have taken place since the first edition. Written by leading international experts, this edition covers various types of tunable laser sources, including tunable semiconductor, solid-state dye, fiber, table-top, free-electron, and interferometric imaging-based lasers. It also provides a practical overview of a wide range of scientific applications in the biological and medical fields, including MEMS and x-ray imaging. The book includes nearly 150 figures and numerous tables and equations.
Catalog no. 60279, August 2008, 480 pp. ISBN: 978-1-4200-6009-6, $169.95 / £108.00 Also available as an eBook
Also available as an eBook
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Biomedical Engineering Design of Biomedical Devices and Systems
Microsurgery
Second Edition
Advances, Simulations and Applications
Paul H. King
Edited by
Vanderbilt University, Nashville, Tennessee, USA
Toshio Fukuda and Carlos Tercero
Richard C. Fries
Nagoya University, Japan
Baxter Healthcare, Round Lake, Illinois, USA
From cardiac pacemakers to magnetic resonance imaging, the design and functional complexity of medical devices have increased over the past 50 years. The second edition of a bestseller, this book provides a comprehensive overview of biomedical device and system design. Presenting topics related to databases, process analysis, and device improvement, it covers all aspects of design that must be considered for complex biomedical projects. This edition features information on device definition and reliability, as well as testing and hardware verification. It also discusses the legal ramifications of medical device development and failure.
Catalog no. 61798, August 2008, 424 pp. ISBN: 978-1-4200-6179-6, $129.95 / £82.99
This book explains the development of in vitro simulators for biomedical applications based on the scientific context in the robotics area. Using endovascular intervention as an example, it presents modeling methods for in vitro representation of human tissue and for representing tissue integrity during endovascular surgery simulation. The book explores applications of this in vitro vasculature modeling technology, including flow control for human blood pressure simulation, computer fluid dynamics simulations using vasculature morphology, catheter insertion robot control and vasculature imaging based on magnetic trackers, and tailor-made scaffolds for blood vessel regeneration.
Catalog no. N10580, April 2012, 300 pp. ISBN: 978-981-4364-69-0, $179.95 / £114.00 Also available as an eBook
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Handbook of Intelligent Scaffold for Tissue Engineering and Regenerative Medicine
Genetic Engineering Recent Developments in Applications Edited by
Dana M. Santos Binghamton University, New York, USA
Edited by
Gilson Khang Chonbuk National University, Jeonju, North Korea
Providing detailed information about fullerene nanowhiskers and the related low-dimensional fullerene nanomaterials, this book introduces tubular nanofibers made of fullerenes, "fullerene nanotubes," and the single crystalline thin film made of C60 known as the "fullerene nanosheet." The first publication featuring the fullerene nanowhiskers made of C60, C70, and C60 derivatives, it demonstrates the synthetic method (liquid–liquid interfacial precipitation). It also examines electrical, mechanical, optical, magnetic, thermodynamic, and surface properties for the fullerene nanowhiskers, as well as their electronic device application. The book includes an extensive bibliography for further research and reading.
A common tool in both research and agriculture, genetic engineering involves the direct manipulation of genes. Today’s areas of medical research include genetic engineering to produce vaccines against disease, pharmaceutical development, and the treatment of disease. In agriculture, genetic engineering is used to modify crops and domestic animals to increase their yields, aid in production, and enhance nutritive aspects. This important book covers new research and studies in genetic engineering in the areas of medicine and agriculture.
Catalog no. N10630, April 2011, 336 pp. ISBN: 978-1-926692-67-8, $99.95 / £63.99 Also available as an eBook
Catalog no. N10464, February 2012, 974 pp. ISBN: 978-981-4267-85-4, $499.95 / £318.00 Also available as an eBook
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Imaging
MRI Essentials for Innovative Technologies Giuseppe Placidi University of L'Aquila, Italy
" … this excellent book should be found on the bookshelves of all those specializing in the field of magnetic resonance." —From the Foreword by Antonello Sotgiu, Professor and Chairman, Department of Health Sciences, Università dell’Aquila, Italy
MRI: Essentials for Innovative Technologies describes novel methods to improve magnetic resonance imaging (MRI) beyond its current limitations. It proposes smart encoding methods and acquisition sequences to deal with frequency displacement due to residual static magnetic field inhomogeneity, motion, and undersampling. Requiring few or no hardware modifications, these speculative methods offer building blocks that can be combined and refined to overcome barriers to more advanced MRI applications, such as real-time imaging and open systems. After a concise review of basic mathematical tools and the physics of MRI, the book describes the severe artifacts produced by conventional MRI techniques. It first tackles magnetic field inhomogeneities, outlining conventional solutions as well as a completely different approach based on time-varying gradients and temporal frequency variation coding (acceleration). The book then proposes two innovative acquisition methods for reducing acquisition time, motion, and undersampling artifacts: adaptive acquisition and compressed sensing. The concluding chapter lays out the author’s predictions for the future of MRI. For some of the proposed solutions, this is the first time the reported results have been published. Where experimental data is preliminary or unavailable, the book presents only numerical solutions. Offering insight into emerging MRI techniques, this book provides readers with specialized knowledge to help them design better acquisition sequences and select appropriate correction methods.
Catalog no. K11872, May 2012, 216 pp. ISBN: 978-1-4398-4040-5, $89.95 / £49.99 Also available as an eBook
Webb's Physics of Medical Imaging Second Edition Edited by
M. A. Flower Institute of Cancer Research/Royal Marsden NHS Foundation Trust, London, UK
Praise for the First Edition: “ … a worthwhile addition to the personal library of anyone connected with this field.” —Journal of Clinical Physics and Physiological Measurement
“This is an excellent publication and represents much dedication and hard work on behalf of the authors and, in particular, the editor.” —RAD Magazine
Since the publication of the best-selling, highly acclaimed first edition, the technology and clinical applications of medical imaging have changed significantly. Gathering these developments into one volume, Webb’s Physics of Medical Imaging, Second Edition presents the basic physics, modern technology and up-to-date examples of clinical application across all the modalities of medical imaging.
New to the Second Edition: • Coverage of state-of-the-art detector technology and computer processing used in medical imaging • Chapters on medical image processing and multimodality imaging • More than 50 percent new examples and over 80 percent new figures Keeping the material accessible to graduate students, this well-illustrated book reviews the basic physics underpinning imaging in medicine. It covers the major techniques of x-radiology, computerized tomography, nuclear medicine, ultrasound and magnetic resonance imaging, in addition to infrared, electrical impedance and optical imaging. The text also describes the mathematics of medical imaging, image processing, image perception, computational requirements, and multimodality imaging.
Features: • Presents the essential physics of medical imaging • Covers each imaging modality in detail, eliminating the need to consult specialized texts • Provides many examples of clinical applications of medical imaging • Includes contributions from leading researchers and clinical scientists • Contains more than 400 high-quality figures, with some in color
Catalog no. IP743, June 2012, 864 pp. ISBN: 978-0-7503-0573-0, $89.95 / £49.99 Also available as an eBook
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Imaging Informatics in Medical Imaging
Image Processing in Radiation Therapy
Edited by
George C. Kagadis
Edited by
University of Patras, Rion, Greece
Kristy Kay Brock
Steve G. Langer
University of Toronto, Ontario, Canada
Mayo Clinic, Rochester, Minnesota, USA
Image Processing in Radiation Therapy presents a complete survey of the techniques involved in medical image processing. It covers the underlying physics associated with the techniques and includes critical evaluation of parametric and non-parametric image registration techniques and their applications in radiation therapy processes. The authors examine image segmentation and reconstruction techniques using image processing across all modalities. They also explore applications of these approaches in radiation therapy. Additional topics include adaptive radiotherapy, as well as the monitoring and tracking of treatment delivery, quantifying accuracy, and visualizing results.
Informatics in Medical Imaging provides a comprehensive survey of the field of medical imaging informatics. In addition to radiology, it also addresses other specialties such as pathology, cardiology, dermatology, and surgery, which have adopted the use of digital images. The book discusses basic imaging informatics protocols, picture archiving and communication systems, and the electronic medical record. It details key instrumentation and data mining technologies used in medical imaging informatics as well as practical operational issues, including procurement, maintenance, teleradiology, and ethics.
Contents: IMAGE PROCESSING IN RADIOTHERAPY APPLICATIONS Image Processing in Adaptive Radiotherapy. Online Monitoring, Tracking, and Dose Accumulation. Quantifying Accuracy of Segmentation and Registration. Visualization. REGISTRATION Rigid and Affine Registration. Optimization Methods. Similarity Metrics. Parametric. Non-Parametric, Elastic. Non-Parametric, Fluid Diffusion. SEGMENTATION Computer-aided Manual Segmentation. Basic Segmentation (Region Growing, Snakes, TextureBased, Multi-Modal Classifications, Etc.). Atlas-Based. Level Set. Registration-Based. ADVANCED IMAGING TECHNIQUES Advancements in Reconstruction (Analytic/Iterative). Advancements in Respiration Sorting. In-Room Imaging Techniques. Challenging Registration (2D to 3D, Functional to Anatomical Images, Surface to Image, Multi-Modality). Image Pre-Processing (Distortion, Noise Minimization, Artifact Reduction).
Catalog no. K11476, December 2012, c. 400 pp. ISBN: 978-1-4398-3017-8, $129.95 / £82.00 Also available as an eBook
Highlights: • Introduces the basic ideas of imaging informatics, the terms used, and how data are represented and transmitted • Emphasizes the fundamental communication paradigms: HL7, DICOM, and IHE • Describes information systems that are typically used within imaging departments: orders and result systems, acquisition systems, reporting systems, archives, and information-display systems • Outlines the principal components of modern computing, networks, and storage systems • Covers the technology and principles of display and acquisition detectors, and rounds out with a discussion of other key computer technologies • Discusses procurement and maintenance issues, ethics and its relationship to government initiatives like HIPAA, and constructs beyond radiology The technologies of medical imaging and radiation therapy are so complex and computer-driven that it is difficult for physicians and technologists responsible for their clinical use to know exactly what is happening at the point of care. Medical physicists are best equipped to understand the technologies and their applications, and these individuals are assuming greater responsibilities in the clinical arena to ensure that intended care is delivered in a safe and effective manner. Built on a foundation of classic and cuttingedge research, this volume supports and updates medical physicists functioning at the intersection of radiology and radiation.
Catalog no. K11526, October 2011, 367 pp. ISBN: 978-1-4398-3124-3, $149.95 / £95.00 Also available as an eBook
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Imaging Coherent Raman Scattering Microscopy
The Fluorescent Protein Revolution
Edited by
Richard N. Day
Ji-Xin Cheng
Indiana University, Indianapolis, USA
Purdue University, Wes Lafayette, Indiana, USA
Xiaoliang Sunney Xie Harvard University, Cambridge, Massachusetts, USA
Covering technical advances and biological applications, Coherent Raman Scattering Microscopy describes the major developments in platforms and laser sources leading to the routine use of coherent Raman microscopes. This authoritative compendium presents the full spectrum of basic and clinical applications of real-time vibrational imaging for in vitro and in vivo systems, showing how these techniques have proven instrumental in disease studies. Edited by one of the pioneers in the field and with contributions from a distinguished team of experts, the book examines existing methods and potential future applications in nanomaterials and live cell imaging. The book covers microscope construction, phase control, fiber laser sources, multimodal imaging, and spectral analysis. It provides a detailed treatment of the broad spectrum of current platforms, including widefield, polarization, interferometric, double-resonance, and multiplex CARS. It also discusses state-of-the-art applications in biomedical studies, infectious disease studies, and liquid crystals and nanomaterials research.
Contents: PRINCIPLES AND TECHNICAL DEVELOPMENT. Basic Theory: Fundamentals of Spontaneous and Coherent Raman Scattering. Platforms: Construction of a CARS Microscope. Multimodal Imaging and Spectral Analysis on a CARS Microscope. Stimulated Raman Scattering Microscopy. Focus-Engineering in CARS Microscopy. Wide-Field CARS. Polarization CARS. Phase Control in CARS Microscopy. FourierTransform CARS. Epi-Detected CARS Microscopy Hyperspectral CARS Microscopy. Interferometric CARS. Double-Resonance CARS. Near-Field Raman and CARS Microscopy. Vibrational Phase Microscopy or Interferometric CARS. Interferometric Multiplex CARS. Multiplex CARS Microscopy. Photonic Crystal Fiber Based M-CARS Microscopy. Fiber-Based Multimodal CARS Imaging. Fiber Laser Sources for CARS Microscopy. Picosecond Fiber Lasers for Coherent Raman Microscopy. APPLICATIONS. CARS Imaging of De and Re-Myelination Ex Vivo and In Vivo. Imaging Lipid Metabolism in C. elegans and Other Model Organisms. Lipid Droplet Biology and Obesity-Related Health Risks. White Matter Injury. Applications of CARS to Infectious Diseases. Study of Liquid Crystals. Live Cell Imaging by Multiplex CARS Microscopy. Study of Nanomaterials on a CARS Microscope. Applications of SRS Microscopy.
Edited by
Michael W. Davidson Florida State University, Tallahassee, USA
The discovery and subsequent applications of green fluorescent protein constitute the first step in what has been described as a revolution in biomedical imaging. Fluorescent proteins (FPs) are incredibly important tools for in vivo fluorescence labeling, as they offer the ability to label specific proteins inside the living cell without the need for exogenous synthetic tags or labeled antibodies. The Fluorescent Protein Revolution reflects the enormous strides made in the field from cloning and engineering of FPs with unique photophysical characteristics from a variety of organisms. The book showcases these new probes with emission colors spanning the visible and near-infrared spectral regions and describes novel photophysical properties. The authors highlight how these new probes are used in concert with novel optical imaging techniques, including live cell imaging and super-resolution microscopy.
Contents: History and Perspectives. Introduction to Fluorescent Proteins. Development of Aequorea victoria Fluorescent Proteins. The Quest for New Fluorescent Proteins from Corals. Photophysical Properties of Fluorescent Proteins. Lessons Learned from the Structure of Aequorea Victoria Fluorescent Proteins. Development of Optimized Fluorescent Proteins. Development of New Colors from Coral Fluorescent Proteins. The Search for the Grail: Optimal Red Fluorescent Proteins. Optical Highlighters. Far Red and Near Infared Fluorescent Proteins. Applications. Genetically Encoded Fluorescent Proteins and FRAP. Optical Highlighters. Biosensor Probes. Probes for FRET and FLIM. Superresolution Techniques. Whole Animal Imaging with Red, Near-Infrared Probes. Future Prospects.
Catalog no. K13481, January 2013, c. 400 pp. ISBN: 978-1-4398-7508-7, $129.95 / ÂŁ82.00 Also available as an eBook
Catalog no. K13060, November 2012, c. 620 pp. ISBN: 978-1-4398-6765-5, $149.95 / ÂŁ95.00
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Imaging Lung Imaging and Computer Aided Diagnosis Edited by
Ayman El-Baz University of Louisville, Kentucky, USA
Essentials of Functional MRI Patrick W. Stroman
Jasjit S. Suri Global Biomedical Technologies, Inc., California, USA
Lung cancer remains the leading cause of cancerrelated deaths worldwide. Early diagnosis can improve the effectiveness of treatment and increase a patient’s chances of survival. Thus, there is an urgent need for new technology to diagnose small, malignant lung nodules early as well as large nodules located away from large diameter airways because the current technology—namely, needle biopsy and bronchoscopy— fail to diagnose those cases. However, the analysis of small, indeterminate lung masses is fraught with many technical difficulties. Often patients must be followed for years with serial CT scans in order to establish a diagnosis, but inter-scan variability, slice selection artifacts, differences in degree of inspiration, and scan angles can make comparing serial scans unreliable. Lung Imaging and Computer Aided Diagnosis brings together researchers in pulmonary image analysis to present state-of-the-art image processing techniques for detecting and diagnosing lung cancer at an early stage. The book addresses variables and discrepancies in scans and proposes ways of evaluating small lung masses more consistently to allow for more accurate measurement of growth rates and analysis of shape and appearance of the detected lung nodules.
Queen's University, Kingston, Ontario, Canada
"A comprehensive book, combining a strong theoretical background with profound practical hints for the use of fMRI in medical research ... represents a major step forward." —Massimo Filippi, M.D., Department of Neurology, Scientific Institute HSR, Italy
" … useful for both a clinical audience and MR technologists." —W. Einar Mencl, Ph.D., Director of Neuroimaging Research, Haskins Laboratories and Yale University, New Haven, Connecticut
Functional magnetic resonance imaging (fMRI) is widely recognized as one of the most powerful tools available for basic and clinical research. With a minimum of technical jargon and advanced mathematics, Essentials of Functional MRI presents a solid, practical foundation for readers to become conversant with fMRI as a tool for their own research and practice. The author reviews research and clinical applications for disease diagnosis, treatment monitoring, and surgical planning. He also covers the underlying biophysical mechanisms that relate MRI changes to neuronal activity as well as the expanded use of fMRI beyond the brain to the brainstem and spinal cord.
Features:
Exploring all aspects of image analysis of the data, this book examines lung segmentation, nodule segmentation, vessels segmentation, airways segmentation, lung registration, detection of lung nodules, diagnosis of detected lung nodules, and shape and appearance analysis of lung nodules. Contributors also explore the effective use of these methodologies for diagnosis and therapy in clinical applications. Arguably the first book of its kind to address and evaluate image-based diagnostic approaches for the early diagnosis of lung cancer, this text constitutes a valuable resource for biomedical engineers, researchers, and clinicians in lung disease imaging.
• Explains how to design and analyze an fMRI study • Discusses fMRI of the cortex as well as the brainstem and spinal cord • Provides an overview of alternative fMRI methods • Presents detailed examples to clarify material • Contains more than 100 color illustrations • Includes a comprehensive glossary of the extensive jargon used in the field
Catalog no. K12032, August 2011, 496 pp. ISBN: 978-1-4398-4557-8, $189.95 / £114.00
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Catalog no. K10992, June 2011, 311 pp. Soft Cover ISBN: 978-1-4398-1878-7, $79.95 / £49.99
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Imaging
Quantitative MRI in Cancer Edited by
Thomas E. Yankeelov, David R. Pickens, and Ronald R. Price Vanderbilt University, Nashville, Tennessee, USA
“ … useful as an introductory text for imaging scientists and physicians who engage in quantitative cancer imaging methodologies with other modalities, such as nuclear medicine. … the greatest strengths of this book are its breadth of subject matter, the uniformly large numbers of citations provided by the chapter authors, and the detailed index. —Geoffrey Clarke in Medical Physics
Propelling quantitative MRI techniques from bench to bedside, Quantitative MRI in Cancer presents a range of quantitative MRI methods for assessing tumor biology. It includes biophysical and theoretical explanations of the most relevant MRI techniques as well as examples of these techniques in cancer applications. The introductory part of the book covers basic cancer biology, theoretical aspects of NMR/MRI physics, and the hardware required to form MR images. Forming the core of the book, the next three parts illustrate how to characterize tissue properties with endogenous and exogenous contrast mechanisms and discuss common image processing techniques relevant for cancer. The final part explores emerging areas of MR cancer characterization, including radiation therapy planning, cellular and molecular imaging, pH imaging, and hyperpolarized MR. Each of the postintroductory chapters describes the salient qualitative and quantitative aspects of the techniques before proceeding to preclinical and clinical applications. Each chapter also contains references for further study. Leading the way toward more personalized medicine, this text brings together existing and emerging quantitative MRI techniques for assessing cancer. It provides a self-contained overview of the theoretical and experimental essentials and state of the art in cancer MRI.
Catalog no. K11087, September 2011, 338 pp. ISBN: 978-1-4398-2057-5, $129.95 / £82.00
Correction Techniques in Emission Tomography Edited by
Mohammad Dawood, Xiaoyi Jiang, and Klaus Schäfers European Institute for Molecular Imaging, Münster, Germany
“It is refreshing to have a text on emission molecular imaging relevant to animals and human beings with an emphasis on those factors that detract from resolution and quantification. … In sum, this book shows how researchers have overcome limitations in emission tomography noted 40 years ago and have brought the methods to the goal of high spatial resolution and quantification. Most importantly, these advances have enabled clinically useful applications not available to other diagnostic methods.” —Thomas F. Budinger, University of California, Berkeley, USA
Written by an interdisciplinary team of medical doctors, computer scientists, physicists, engineers, and mathematicians, Correction Techniques in Emission Tomography presents various correction methods used in emission tomography to generate and enhance images. It discusses the techniques from a computer science, mathematics, and physics viewpoint. Providing a comprehensive overview of correction techniques at different levels of the data processing workflow, it covers nuclear medicine imaging, hybrid emission tomography, and optical imaging. An important focus in the text is on new and sophisticated motion correction techniques in PET imaging. The book illustrates basic principles as well as recent advances, such as model-based iterative algorithms and 4D methods. Reflecting state-of-the-art research, this volume explores the range of problems that occur in emission tomography. It looks at how the resulting images are affected and presents practical compensation methods to overcome problems and improve images.
Catalog no. K10659, April 2012, 287 pp. ISBN: 978-1-4398-1298-3, $119.95 / £76.99 Also available as an eBook
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Imaging KnowledgeDriven Medicine A Machine Learning Approach Edited by
R. Bharat Rao and Romer Rosales
Optical Imaging Techniques in Cell Biology Second Edition
Siemens Medical Solutions, Malvern, Pennsylvania, USA
Glenn Fung Siemens Medical Solutions, Madison, Wisconsin, USA
Focusing on several recent, novel machine learning automatic algorithms, this reference is the first resource on the use of machine learning methods in designing computer-aided diagnosis (CAD) systems. It proposes a framework for CAD problems, presents the technical issues involved when building classifiers, and provides the appropriate machine learning techniques to address these problems. The book also includes results and concrete examples for different diseases and imaging modalities. It is a useful tool for researchers and students in the biomedical sciences and machine learning as well as for students in advanced courses on CAD and/or medical informatics.
Guy Cox University of Sydney, New South Wales, Australia
A solid reference on optical imaging techniques, this volume covers the field from the basics of the optical microscope to highly advanced techniques such as Förster resonant energy transfer (FRET) and fluorescence lifetime imaging microscopy (FLIM). Using a uniform style and format, it explains the underlying principles so readers can learn the benefits and limitations of each technique. Topics include optical contrasting techniques, fluorescence and fluorescence microscopes, 3D imaging, the confocal microscope, nonlinear microscopy, advanced fluorescence techniques, and breaking the diffraction limit.
Catalog no. K12150, June 2012, 316 pp. ISBN: 978-1-4398-4825-8, $149.95 / £95.00 Also available as an eBook
Catalog no. K11767, April 2013, c. 300 pp. ISBN: 978-1-4398-3887-7, $89.95 / £54.99 Also available as an eBook
Targeted Molecular Imaging
Physics of Mammographic Imaging
Edited by
Michael J. Welch Washington University, Saint Louis, Missouri, USA
William C. Eckelman University of California, San Diego, La Jolla, USA
This volume covers the development of new diagnostic approaches using an imaging probe and agent to noninvasively visualize cellular processes in normal and disease states. It discusses the concept, development, preclinical studies, and in many cases, translation to the clinic of targeted imaging agents. Case studies examine the development and translation of non-nuclear probes and radiotracers. Other sections address in vitro studies, small animal research, and the application of targeted probes for nuclear, optical, and MRI imaging. The book also describes how various investigators approach the task of validating a new targeted probe.
Catalog no. K11953, February 2012, 388 pp. ISBN: 978-1-4398-4195-2, $169.95 / £108.00 Also available as an eBook
Edited by
Mia K. Markey The University of Texas, Austin, USA
With a focus on the fundamentals of image formation, image interpretation, analysis, and modeling, this text is a comprehensive treatment of developments in the mammography field. It explores the use of mammographic imaging in the detection, diagnosis, treatment planning, and monitoring of breast cancer. Expert authors give a balanced summary of core topics such as digital, contrast-enhanced, and stereo mammography; breast tomosynthesis; and breast CT. The book highlights the use of mammographic imaging with complementary breast imaging modalities including ultrasound, MRI, and nuclear medicine techniques. It also discusses critical issues such as computer-aided diagnosis, informatics, and quality assurance.
Catalog no. K13500, November 2012, c. 360 pp. ISBN: 978-1-4398-7544-5, $179.95 / £114.00 Also available as an eBook
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Imaging Comprehensive Brachytherapy Physical and Clinical Aspects
Human Eye Imaging and Modeling
Edited by
Edited by
Jack Venselaar, Dimos Baltas, Ali Soleimani-Meigooni, and Peter J. Hoskin
E. Y. K. Ng, Jen Hong Tan, U. Rajendra Acharya, and Jasjit S. Suri
Brachytherapy delivers a highly localized dose of radiation to a target region using radionuclides implanted in or very near to the tumor. This book provides a complete overview of the technique and covers related delivery modalities such as electronic brachytherapy. Along with exploring new clinical protocols, it discusses major advances under development, including those related to imaging, robotics, strategies for improved dosimetry, Monte Carlo-based dose calculation, and optimization. The first part of the text explores the underlying physics, design, and implementation of the techniques. The second part provides a practical guide for practitioners.
Advanced image processing and mathematical modeling techniques are increasingly being used for the early diagnosis of eye diseases. This comprehensive reference details the latest advances and computerbased techniques in imaging and modeling of the human eye. Featuring contributions by well-known experts in the field, it covers imaging of fundus and infrared images, diagnosis of diabetes retinopathy and glaucoma, estimation of tear evaporation of dry eye, computer simulation of the human eye based on principles of heat transfer, and various bioheat equations to predict interior temperatures based on the surface temperatures.
Catalog no. K11997, November 2012, c. 568 pp. ISBN: 978-1-4398-4498-4, $199.95 / £127.00
Catalog no. K13217, June 2012, 430 pp. ISBN: 978-1-4398-6993-2, $189.95 / £121.00
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Adaptive Motion Compensation in Radiotherapy Edited by
Medical Imaging Principles and Practices Edited by
Mostafa Analoui
Martin J. Murphy
The Livingston Group, Madison, Wisconsin, USA
Virginia Commonwealth University, Richmond, USA
Joseph D. Bronzino
Reflecting recent advances in the field, this book provides the first detailed treatment of online interventional techniques for motion compensation radiotherapy. It explains how adaptive motion intervention is imaging-intensive and relies on near real-time image acquisition and processing. With a focus on the strategy of online motion compensation, the book discusses necessary motion detection methodology, repositioning methodology, and how to interpret and respond to target movement data in real time. Using examples that explain methods of detection and correction, the book also examines the distinct problems in dose planning and delivery posed by each adaptation technology.
Donald R. Peterson
Catalog no. K11160, December 2011, 165 pp. ISBN: 978-1-4398-2193-0, $149.95 / £95.00 Also available as an eBook
Simsbury, Connecticut, USA University of Connecticut, Farmington, USA
Focusing on those with established clinical utilization, this book offers a selective review of key imaging modalities. It provides a detailed overview of x-ray imaging and computed tomography, fundamental concepts in signal acquisition and processes, functional MRI (fMRI), and chemical shift imaging. It also covers topics in Magnetic Resonance Microcopy, the physics of instrumentation and signal collection, and their applications in clinical practice. The wide selection of topics provides readers with an appreciation of the depth and breadth of the field and the challenges facing the technical and clinical community of researchers and practitioners.
Catalog no. K13254, October 2012, c. 400 pp. ISBN: 978-1-4398-7102-7, $99.95 / £63.99 Also available as an eBook
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Imaging Image Processing
Medical Infrared Imaging
Tensor Transform and Discrete Tomography with MATLAB®
Principles and Practices Mary Diakides Advanced Concepts Analysis, Inc., Falls Church, Virginia, USA
Artyom Grigoryan
Joseph D. Bronzino
San Antonio, Texas, USA
Merughan M. Grigoryan Yezeman, Armenia
This book is devoted to the problem of image reconstruction from a finite number of projections. It describes 2D discrete Fourier transform—including properties, fast algorithms, and applications of Fourier transform methods in image processing. It also presents traditional methods of 2D computerized tomography, including Fourier transform-based methods of filtered back projection and algebraic methods. The authors show readers new approaches and new forms of image representation, which can be used effectively in image processing and computerized tomography. All solutions of the image reconstruction problem are accomplished with examples and MATLAB®-based codes.
Catalog no. K14749, September 2012, c. 456 pp. ISBN: 978-1-4665-0994-8, $149.95 / £95.00
Simsbury, Connecticut, USA
Donald R. Peterson University of Connecticut, Farmington, USA
This book explores new ideas, concepts, and imaging technologies such as dynamic thermal imaging, thermal texture mapping, and thermal multispectral imaging commonly used in the clinical environment. The authors discuss the historical background of infrared imaging, clinical applications, standards, and technology. An essential reference for the medical and biomedical engineering communities, the book provides a springboard for developing and conducting multidisciplinary research in many areas of medical infrared imaging.
Catalog no. K13338, October 2012, c. 576 pp. ISBN: 978-1-4398-7249-9, $99.95 / £63.99 Also available as an eBook
Also available as an eBook
Monte Carlo Calculations in Nuclear Medicine Second Edition, Applications in Diagnostic Imaging Edited by
Michael Ljungberg and Sven-Erik Strand Lund University Hospital, Sweden
Michael A. King University of Massachusetts Medical Center, Worcester, USA
From first principles to current computer applications, this book covers the applications of Monte Carlo calculations in nuclear medicine and critically reviews them from a diagnostic perspective. New chapters in this edition cover codes and applications in pre-clinical PET and SPECT. The book explains how Monte Carlo methods and software packages are applied to evaluate scatter in SPECT and PET imaging, collimation, and image deterioration. A guide for researchers developing methods to improve image resolution, it also demonstrates how Monte Carlo techniques can be used to simulate complex imaging systems.
Catalog no. K11910, November 2012, c. 392 pp. ISBN: 978-1-4398-4109-9, $129.95 / £82.00
Physics of Thermal Therapy Fundamentals and Clinical Applications Edited by
Eduardo Moros Moffitt Cancer Center, Tampa, Florida, USA
Focusing on applications in cancer treatment, this book covers basic principles, practical aspects, and clinical applications of thermal therapy. An overview of the fundamentals shows how use of controlled heat in medicine and biology involves electromagnetics, acoustics, thermodynamics, heat transfer, and imaging science. The book discusses challenges in the use of thermal energy on living tissues and explores genetic, cellular, and physiological responses that may help in combating cancer. It also highlights recent advances, including the treatment of solid tumors using image-guided thermal therapy, microbubbles, nanoparticles, and other cutting-edge techniques.
Catalog no. K12209, December 2012, c. 424 pp. ISBN: 978-1-4398-4890-6, $149.95 / £95.00 Also available as an eBook
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Imaging Physics for Diagnostic Radiology Third Edition P. P. Dendy Addenbrookes NHS Trust, Cambridge, UK
B. Heaton
Data Mining in Biomedical Imaging, Signaling, and Systems Edited by
Sumeet Dua
Aberdeen Radiation Protection Services, UK
Louisiana Tech University, Ruston, USA
Fully revised and updated, this volume describes how various imaging techniques work. Now in its third edition, it includes new chapters on PET and PACS as well as new material on digital receptors, radiation doses and risks to patients, and special radiographic techniques, including subtraction techniques and interventional radiology. It also emphasizes the differences between analogue and digital images and covers multi-slice CT and 3D resolution, dual energy applications, and cone beam CT. End-of-chapter exercises and several multiple choice questions at the back of the book test reader comprehension.
Rajendra Acharya U
Catalog no. 83155, August 2011, 720 pp. ISBN: 978-1-4200-8315-6, $79.95 / £49.99 Also available as an eBook
Ngee Ann Polytechnic, Singapore
This comprehensive volume demonstrates the broad scope of uses for data mining and includes detailed strategies and methodologies for analyzing data from biomedical images, signals, and systems. Written by experts in the field, it presents data mining techniques in the context of important clinical issues, including diagnosis and grading of depression, identification and classification of arrhythmia and ischemia, and classification paradigms for mammograms. The book provides essential information and techniques to benefit researchers, practitioners, and educators of biomedical science and engineering.
Catalog no. K11798, May 2011, 440 pp. ISBN: 978-1-4398-3938-6, $109.95 / £66.99 Also available as an eBook
Diffuse Optical Tomography Principles and Applications
Photoacoustic Imaging and Spectroscopy Edited by
Huabei Jiang
Lihong Wang
University of Florida, Gainesville, USA
Washington University, St. Louis, Missouri, USA
Diffuse optical tomography (DOT) is an imaging method based on near infrared optical technologies and model-based inverse computations. It can provide spatial distributions of intrinsic tissue optical properties or molecular contrast agents through model-based reconstruction algorithms using NIR measurements along or near the boundary of tissue. This book covers almost every aspect of DOT—from mathematics, reconstruction algorithms, instrumentation, and phantom experiments to clinical applications. The text covers the fundamental principles, including its mathematical foundations and computational methods, and explains how to set up experimental image systems and adapt laboratory study results for use in clinical applications.
While photoacoustic imaging is probably the fastest growing biomedical imaging technology, this is the first comprehensive volume in this emerging field to cover both the physics and the noninvasive applications that are changing diagnostic medicine. Reviewing both functional and molecular imaging, the book examines the state of the art in this exciting area of research, offering complete coverage of photoacoustic, optoacoustic, and thermoacoustic imaging. Featuring 200 illustrations, this volume illustrates the superiority of photoacoustic images over x-ray and ultrasonic images. It also discusses potential applications of photoacoustic technology, including biomedical applications.
Catalog no. K12111, December 2010, 375 pp. ISBN: 978-1-4398-4757-2, $135.95 / £87.00
Catalog no. 59912, March 2009, 518 pp. ISBN: 978-1-4200-5991-5, $159.95 / £99.00 Also available as an eBook
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25
Imaging Automated Image Detection of Retinal Pathology
Biosignal and Medical Image Processing Second Edition
Herbert F. Jelinek Medical University of Vienna, Austria
Michael J. Cree University of Waikato, Hamilton, New Zealand
John L. Semmlow Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Offering an array of informative examples, this book analyzes the use of automated computer techniques such as pattern recognition in analyzing retinal images and detecting diabetic retinopathy and other retinal-based diseases and their progression. It also addresses the benefits and challenges of automated health care in the field of ophthalmology. The book details the increasing practice of telemedicine screening and other advanced applications including arteriolar-venous ratio, which has been shown to be an early indicator of cardiovascular, diabetes, and cerebrovascular risk.
Now in its second edition, this popular resource provides a complete set of signal processing tools, including those for diagnostic decision-making and for classification. Using non-mathematical descriptions that help readers attain the practical knowledge necessary for correct application of these tools, the book explores adaptive neural nets, linear discriminators, and support vector machines. Examples and problems in MATLAB® encourage exploration of important properties of signal and image processing tools. An accompanying CD-ROM provides data, support subroutines, and source code from examples in the text.
Catalog no. 7556, October 2009, 384 pp. ISBN: 978-0-8493-7556-9, $149.95 / £96.00
Catalog no. 62301, October 2008, 472 pp. ISBN: 978-1-4200-6230-4, $107.95 / £69.99
Also available as an eBook
Also available as an eBook
Image Processing with MATLAB® Applications in Medicine and Biology
This text explains complex, theory-laden topics in image processing through examples and MATLAB® algorithms, helping scientists and researchers quickly identify the most effective solution method for a particular problem. The authors emphasize 3D processing and analysis as well as statistical and stochastic modeling. They cover new areas of nonlinear diffusion filtering and PDE-based image filtering, address relatively advanced topics such as Markov random fieldbased image segmentation, and highlight applications with images from medicine and biology. They also include real-world examples and exercises in every chapter. The book enables a diverse set of readers to comprehend the material by striking the right balance between theory and practice
Catalog no. 9246, December 2008, 451 pp. ISBN: 978-0-8493-9246-7, $107.95 / £69.99
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Diagnostics, Imaging, and Therapeutics Edited by
Omer Demirkaya, Musa Hakan Asyali and Prasanna K. Sahoo
Also available as an eBook
Pulmonary Nanomedicine
Neeraj Vij Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
This book provides an in-depth view of engineered nanomaterial (ENM) pulmonary effects and familiarizes readers with unique aspects of nanomaterial application and research. Focusing on the diagnostic and therapeutic utilities of nanomaterials in different lung diseases, the book discusses novel applications of nanotechnology for the treatment of airway diseases such as asthma, allergy, chronic obstructive pulmonary diseases, cystic fibrosis, and lung cancer. It also discusses strategies to overcome pathophysiological and technical barriers. The book is a critical resource for pulmonary biologists, chemists, and clinicians developing novel nano-based diagnostics, imaging, and therapeutics tools for airway diseases.
Catalog no. N10499, May 2012, 300 pp. ISBN: 978-981-4316-48-4, $149.95 / £95.00 Also available as an eBook
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Nanotechnology
The Nanobiotechnology Handbook Edited by
Learning BioMicroNanotechnology
Yubing Xie
Mel I. Mendelson
University at Albany, State University of New York, USA
Loyola Marymount University, Los Angeles, California, USA
Offering a uniquely thorough overview of nanobiotechnology and its place in today’s advancements in applied science, The Nanobiotechnology Handbook is a comprehensive text combining contributions from bioorganic and bioinorganic chemistry, molecular biology, materials science, bioanalysis, and bioenergy to address the full scope of current and future developments. World-class experts discuss the role of nanobiotechnology in bioanalysis, biomolecular nanotechnology, biosensors, and the use of nanotechnology in biofuels. Extensive references within each chapter facilitate further investigation into the field.
A primary text for undergraduate nanotechnology courses, Learning Bio-Micro-Nanotechnology is designed for students who lack a cross-disciplinary background and knowledge of micro- and nanotechnology. Clearly and concisely written, it contains examples, questions, and problems divided into three hierarchical learning skills that involve understanding, analyzing, and evaluating the concepts. The author breaks down the boundaries between biology, chemistry, physics, engineering and ethics by co-mingling the vocabulary and concepts of these disciplines around bio-applications. Copiously illustrated, this text leans heavily towards biological and biomedical applications and includes a comprehensive chapter on ethics.
Contents: Biomolecular Nanotechnology. Nanosynthesis and Nanofabrication for BioApplications. Biomimetic Nanotechnology. Nanotechnology in Biomolecular Manipulation. Nanobiotechnology in Bioanalysis. Analysis of Nanostructures and Nanobiosystems. Biomedical Nanotechnology. Individual chapters on Nanotechnology in Drug Delivery, Gene Delivery, Stem Cells, Cell Therapy, Tissue Engineering, Medicine, Vaccines, Cancer, Cardiovascular Disease, Surgery, Organ Transplantation, Personal Medicine, Imaging, and Diagnostics. Nanotechnology in Bioenergy. Biologically-inspired Energy Storage Devices. Biologically-inspired Energy Synthesis and Conversion. Nanotechnology in Biocatalysis. Nanotechnology in Biofuels. Nanotechnology in Biosensors. Sensing Elements. Detections. Systems. Applications. Nanobiotechnology Impacts. Nanotoxicity and Environmental Impact. IP Strategies, Patenting Inventions and Commercialization of Nanobiotechnology. Economic, Ethical, and Societal Implications of Nanobiotechnology. Education and Workforce Development in Nanobiotechnology.
Catalog no. K11758, November 2012, c. 564 pp. ISBN: 978-1-4398-3869-3, $169.95 / £108.00 Also available as an eBook
Contents: Thinking Small and Big Bio-Molecules and Cells Molecular Chemistry Engineering Bits and Bytes Seeing Small Things !-Electro-Mechanical Devices Bio-Applications Risks-Nano or Mega Ethics and Social Values Predictions –Year 2025
About the Author: Mel I. Mendelson attained his Ph.D. in materials science from Northwestern University, one of the leading universities in bio-nanotechnology. He worked for 20 years in the micro-electronics and aerospace industries prior to entering academia in 1994. Currently, he is a professor of mechanical engineering at Loyola Marymount University.
Catalog no. 82035, October 2012, c. 606 pp. ISBN: 978-1-4200-8203-6, $89.95 / £57.99 Also available as an eBook
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Nanotechnology Tissue Engineering and Regenerative Medicine A Nano Approach Edited by
Murugan Ramalingam, Pekka Vallittu, Ugo Ripamonti, and Wan-Ju Li Tissue Engineering and Regenerative Medicine: A Nano Approach bridges the gap between nanotechnology and regenerative medicine to facilitate their transition from lab to the clinic. It compiles important aspects of the basic science and fundamental principles to current nanotechnological innovations in biomaterials, cell, tissue, and organ engineering. The book explores their clinical relevance as well as future trends in regenerative medicine. It is intended for a wide audience including students, researchers, professors, and industrial experts working in the fields of biomaterial science and engineering, nanoscience and nanotechnology, bioengineering, cell biology, biomedical sciences, tissue engineering, and nanomedicine.
Contents: Biostable Composite Biomaterials in Medical Applications. Bioceramic and Biopolymer Nanocomposite Materials for Use in Orthopedic Applications. Tailoring of Bioactive Glasses. Bioactive Ceramic Coatings for Metallic Implants. Bone: Formation by Induction by Calcium Phosphate–Based Biomimetic Macroporous Constructs. Bioinspired Titanium Implants—Concavity: Shape of Life. Bioactive Surface Modifications for Dental and Orthopedic Implants. Oral Implants—Biological Background and Current Concepts in Peri-implantitis Treatment. Soft Tissue Attachment on Implant Surface. Surface Chemical Determination of the Placement, Growth, and Differentiation of Cells for Drug Screening, Toxin Detection, and Lab-on- a- Chip Applications. Electrospun Nanofibers as Next-Generation Bioactive Tissue Scaffolds. Mechanics of Fiber-Reinforced Scaffolds and Tissues Formed from Organized Electrospun Assemblies. Regulation of Stem Cell Behavior Using Nanobiomaterials. Biomaterials and Their Use in Craniofacial Surgery. Nanobiomaterials for Bone Tissue Engineering. Stem Cells, Growth Factors, and Biomaterials in Bone Surgery. Nanomaterials for Cartilage Regeneration. Cartilage Tissue Engineering: Advances in Stem Cell–Based Approaches. Stem Cells and Nanobiomaterials for Cardiac Tissue Regeneration. Nanotechnology for Engineering Cellular Microenvironment and Gene Delivery. Nanobiomaterial-Based Short Interfering RNA Delivery Systems. Sugar–Glass Nanoparticles for Protein Delivery. Clinical Relevance of Tissue Engineering. Future Perspectives of Biomaterials and Stem Cells in Regenerative Medicine. Index.
Nanotechnology and Human Health Ineke Malsch Malsch Techno Valuation, Utrecht, Netherlands
Nanotechnology has a myriad of applications in medicine, agriculture, and the environment. The advancements that have come forth bring a host of concerns about the potential of these applications for the greater good of society. Nanotechnology and Human Health reviews current scientific and technical developments in nanotechnology for biomedical, agrofood, and environmental applications. This collection of perspectives on the ethical, legal, and societal implications of bionanotechnology provides unique insight into contemporary technological developments. Readers with a technical background will appreciate the overview of the state-of-the-art research in their field, while those with a social science background will benefit from the discussion of realistic prospects of nanotechnology. The text includes a glossary and extensive end-of-chapter references.
Features: • Provides an overview of nanotechnology for biomedical, agrofood, and environmental applications • Reviews global trends in government industrial research • Offers a realistic and balanced analysis of the short- to medium-term implications for people and the environment • Details ways in which to lay the foundations for a global ethical code of conduct for nanotechnology
Contents: Biomedical Nanotechnology Overview Nanotechnology and Agrofood and Water Bionanotechnology and the Environment Ethical, Legal, and Social Implication of Bionanotechnology
Catalog no. 8144, January 2013, c. 300 pp. ISBN: 978-0-8493-8144-7, $139.95 / £89.00 Also available as an eBook
Catalog no. K13868, October 2012, c. 600 pp. ISBN: 978-1-4398-8185-9, $149.95 / £95.00 Also available as an eBook
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Nanotechnology
Edited by
Medical Nanotechnology and Nanomedicine
Balaji Sitharaman
Harry F. Tibbals
State University of New York at Stony Brook, USA
University of Texas Southwestern Medical Center, Dallas, USA
Nanobiomaterials exhibit distinctive characteristics, including mechanical, electrical, and optical properties, which make them suitable for a variety of biological applications. Because of their versatility, they are poised to play a central role in nanobiotechnology and make significant contributions to biomedical research and healthcare. Nanobiomaterials Handbook offers a broad introduction for those new to the subject and serves as a useful reference for advanced professionals.
This accessible guide reviews advances in nanoscience and nanotechnology and considers their applications in medicine. Providing an introduction to both the science and the infrastructure required to support these advances, the book is written for non-experts, including medical researchers and clinicians, as well as those concerned with business aspects, regulation, and the administration of medical practices. Divided into three parts, the first presents a historical overview, the second investigates the current status of the field and its applications, and the third looks at future directions and possibilities. Representative examples, case summaries, and graphical illustrations enhance the text.
Nanobiomaterials Handbook
Analyzing major topics and disciplines in this arena, this volume: • Defines scope, current status, and future prospects of nanobiomaterials • Surveys nanobiomaterials and examines various synthesis and processing techniques important for developing nanobiomaterials • Explores the unique nanoscopic physicochemical properties of nanobiomaterials • Discusses potential applications, emphasizing unique challenges in the design, fabrication, and evaluation of biomaterials for a particular application or field • Provides a detailed overview of the interactions between bionanomaterials/biological systems and the biocompatibility issues associated with bionanomaterials Further progress in nanobiomaterials requires a multidisciplinary approach spanning major fields in physical and biological sciences, engineering, and medicine with considerable collaboration between ethicists, regulatory bodies, and industry. This volume brings together the work of a team of worldrenowned experts from various fields who discuss the vast potential for nanobiomaterials in a myriad of applications.
Catalog no. 94661, June 2011, 737 pp. ISBN: 978-1-4200-9466-4, $169.95 / £108.00 Also available as an eBook
Catalog no. K10431, September 2010, 527 pp. Soft Cover ISBN: 978-1-4398-0874-0, $72.95 / £45.99 Also available as an eBook
Bionanotechnology II Global Prospects Edited by
David E. Reisner The Nano Group, Inc., Farmington, Connecticut, USA
The impact and importance of nanotechnology continues to grow, and nanomedicine and biotechnology have become areas of increased development. Biomedical engineers who work with biological processes and structures must have a deeply rooted understanding of the role of bionanotechnology, a rapidly evolving sector of the nanotechnology field. This volume, a follow-up to the editor’s highly successful first volume, contains 26 entirely new contributions that provide a broad survey of research shaping this critical field. With coverage of technical and nontechnical areas, the book offers representative reporting on a wide variety of activity from around the world. It discusses the role of nanotechnology in novel medical devices, bioanalytical technologies, and nanobiomaterials.
Catalog no. K10254, August 2011, 583 pp. ISBN: 978-1-4398-0463-6, $99.95 / £63.99 Also available as an eBook
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Nanotechnology
Bionanotechnology Nanoimaging
Maheshwar Sharon IIT Bombay (Retired), Birla College, Nanotechnology Research Center, India
Edited by
Madhuri Sharon
Beth A. Goins and William T. Phillips
Monad Nanotech Pvt. Limited, Mumbai, India
University of Texas, San Antonio, USA
Highlighting the human applications of the science, this volume discusses the fundamental concepts and underlying science of bionanotechnology and the bionanomachines that result from advances in this exciting new field. Distilling the author’s research and groundbreaking original experimentation, chapters cover bionanomachines and their use with and manipulation of DNA, RNA, proteins, carbohydrates, and lipids. Well-documented and authoritative, the book offers students and scientists alike the foundational information required to advance in this powerful and potentially life-altering field.
The first resource of its kind, this book examines cutting-edge research on the use of nanoparticles for in vivo diagnostic medical imaging and therapy. It discusses a variety of nanoparticles, including quantum dots, carbon nanotubes, dendrimers, gold nanoshells, metal nanorods, micelles, liposomes, polymers, MRI iron oxide particles, and microbubbles. Examples in the book include multifunctional nanoparticles designed for multimodality imaging and simultaneous diagnostic and therapy (theranostic) applications.
Catalog no. K12393, May 2012, 300 pp. ISBN: 978-1-4398-5214-9, $79.95 / £49.99
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Nanotechnology for Cancer Therapy Edited by Northeastern University, Boston, Massachusetts, USA
Encouraging communication between clinical investigators and nanoscientists, this text focuses specifically on effective and promising nanoscience and nanotechnology strategies for imaging and treating cancer. Renowned industrial and academic researchers describe the advantages of nanoparticles as sensing, delivery, image enhancement agents for cancer treatments, and various types of useful nanoparticles such as polymeric nanoparticles and dendrimers. Among the various approaches considered, nanotechnology offers the best promise for the targeted delivery of drugs and genes to a tumor site and for alleviating side effects of chemotherapeutic agents.
Catalog no. 7194, December 2006, 840 pp. ISBN: 978-0-8493-7194-3, $219.95 / £140.00
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Understanding Nanomedicine An Introductory Textbook Rob Burgess
Mansoor M. Amiji
Also available as an eBook
Catalog no. N10430, September 2011, 350 pp. ISBN: 978-981-4267-09-0, $149.95 / £95.00
Medical Nanotechnologies Incorporated, Richardson, Texas, USA
The application of nanotechnology to medicine has burgeoned into a growing field, with funding from the National Institutes of Health and wide interest from all scientific sectors. This volume comprehensively covers a broad range of therapeutic and diagnostic applications of nanotechnology. Providing a dynamic learning experience, the book intersperses cutting-edge discoveries with historical perspectives. Preliminarily, the text discusses the basic principles of nanotechnology—focusing on nanomaterials and nanoparticles. These are the sectors that hold the most promise for the future of medicine. The book then progresses to nanomedicine as it applies to current and future society.
Catalog no. N10477, June 2012, 524 pp. ISBN: 978-981-4316-38-5, $149.95 / £95.00
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Neuroscience Neuromorphic Olfaction Edited by
Krishna C. Persaud The University of Manchester, UK
Santiago Marco and Augustin GutierrezGalvez University of Barcelona, Spain
With biological components of chemical sensing systems now becoming well understood in terms of their structure and function, it is possible to consider biomimetic models of olfaction and how they may be translated into functional engineering devices. This book presents an innovative interdisciplinary biomimetic approach to olfaction. Covering biology, hardware, software, and sensors, the text explores contributions to the realization of novel chemical sensing systems inspired by biological pathways. The book describes cutting-edge research as well as the engineering aspects of olfaction, odor coding of neurons, chemical sensor arrays, and biologically modeled sensor robots.
Catalog no. K13286, January 2013, c. 352 pp. ISBN: 978-1-4398-7171-3, $149.95 / £95.00 Also available as an eBook
Epileptic Seizures and the EEG Measurement, Models, Detection and Prediction Andrea Varsavsky and Iven Mareels The University of Melbourne, Australia
Mark Cook St. Vincent's Hospital and the University of Melbourne, Victoria, Australia
A study of epilepsy from an engineering perspective, this volume begins by summarizing the physiology and the fundamental ideas behind the measurement, analysis and modeling of the epileptic brain. It introduces the EEG and provides an explanation of the type of brain activity likely to register in EEG measurements, offering an overview of how these EEG records are and have been analyzed in the past. The book focuses on the problem of seizure detection and surveys the physiologically-based dynamic models of brain activity. Finally, it addresses the fundamental question: can seizures be predicted?
Catalog no. K10604, December 2010, 370 pp. ISBN: 978-1-4398-1200-6, $145.95 / £93.00 Also available as an eBook
Epilepsy The Intersection of Neurosciences, Biology, Mathematics, Engineering, and Physics Edited by
Ivan Osorio, Hitten P. Zaveri, Mark G. Frei, and Susan Arthurs
Automated EEGBased Diagnosis of Neurological Disorders Inventing the Future of Neurology Hojjat Adeli The Ohio State University, Columbus, USA
Samanwoy Ghosh-Dastidar Ardmore, Pennsylvania, USA
Integrating the studies of epilepsy, neurosciences, computational neurosciences, mathematics, physics, engineering, and medicine, this volume provides the first means to a clear, structured, and enriching multidisciplinary perspective for developing students, researchers, and clinicians in the field of epilepsy. The text gives up-to-date information on the state of current research, possible future research, and clinical directions in the fields of epilepsy and seizure dynamics. Clear illustrations that illustrate the patterns of brain electrophysiology and behavioral manifestations are provided to aid comprehension. The authors include extensive references in each chapter to enhance further study.
Based on the authors' ground-breaking research, this book presents a novel approach for automated EEGbased diagnosis of neurological disorders such as epilepsy. The authors have developed an innovative method shown to diagnose epilepsy and detect seizure with an accuracy rate of 96 percent. Their method is based on the adroit integration of three computing and problem solving paradigms: neural networks, wavelets, and chaos theory. The text introduces each of these computing paradigms along with a number of sophisticated mathematical algorithms. It concludes with applications of the method to epilepsy and to Alzheimer's disease.
Catalog no. K11766, May 2011, 546 pp. ISBN: 978-1-4398-3885-3, $189.95 / £121.00
Catalog no. K10784, February 2010, 423 pp. ISBN: 978-1-4398-1531-1, $169.95 / £108.00
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Also available as an eBook
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Sensors & Signals
Second Edition
Analysis and Application of Analog Electronic Circuits to Biomedical Instrumentation
Kayvan Najarian
Second Edition
New Edition of a Bestseller!
Biomedical Signal and Image Processing Virginia Commonwealth University, Richmond, USA
Robert B. Northrop University of Connecticut, Storrs, USA
Robert Splinter University of North Carolina at Charlotte, USA
First published in 2005, Biomedical Signal and Image Processing received wide and welcome reception from universities and industry research institutions alike, offering detailed yet accessible information at the reference, upper undergraduate, and first-year graduate levels. Retaining all of the quality and precision of the first edition, Biomedical Signal and Image Processing, Second Edition offers a number of revisions and improvements to provide the most up-todate resource available on the fundamental signal and image processing techniques used to process biomedical information. Addressing the application of standard and novel processing techniques to some of today’s principle biomedical signals and images, the book begins with an introduction to digital signal and image processing— discussing Fourier transform, image filtering, edge detection, and wavelet transform. The second section investigates specific biomedical signals, such as ECG, EEG, and EMG, while the third focuses on imaging using CT, x-ray, MRI, ultrasound, positron, and other biomedical imaging techniques. Updated and expanded, the book offers numerous additional—predominantly MATLAB®—examples for all chapters to illustrate the concepts described in the text and ensure a complete understanding of the material. The author takes great care to clarify ambiguities in some mathematical equations and to further explain and justify the more complex signal and image processing concepts, offering a complete and understandable approach to complicated concepts.
Features: • Provides updated chapters and all-new examples • Presents expanded end-of-chapter questions • Offers enhanced illustration of concepts presented in the first edition • Includes instructional materials for lecture notes on the course web page
Catalog no. K13235, May 2012, 411 pp. ISBN: 978-1-4398-7033-4, $99.95 / £63.99 Also available as an eBook
Analysis and Application of Analog Electronic Circuits to Biomedical Instrumentation, Second Edition helps biomedical engineers understand the basic analog electronic circuits used for signal conditioning in biomedical instruments. It explains the function and design of signal conditioning systems using analog ICs—the circuits that enable ECG, EEG, EMG, ERG, tomographic images, biochemical spectrograms, and other crucial medical applications. This book demonstrates how op amps are the keystone of modern analog signal conditioning system design and illustrates how they can be used to build instrumentation amplifiers, active filters, and many other biomedical instrumentation systems and subsystems. It introduces the mathematical tools used to describe noise and its propagation through linear systems and looks at how signal-to-noise ratios can be improved by signal averaging and linear filtering.
Features • Analyzes the properties of photonic sensors and emitters and the circuits that power them • Details the design of instrumentation amplifiers and medical isolation amplifiers • Considers the modulation and demodulation of biomedical signals • Examines analog power amplifiers, including power op amps and class D (switched) PAs • Describes wireless patient monitoring, including Wi-Fi and Bluetooth communication protocols • Explores RFID, GPS, and ultrasonic tags and the design of fractal antennas • Addresses special analog electronic circuits and systems such as phase-sensitive rectifiers, phase detectors, and IC thermometers By explaining the “building blocks” of biomedical systems, the author illustrates the importance of signal conditioning systems in the devices that gather and monitor patients’ critical medical information. Fully revised and updated, this second edition includes new chapters, a glossary, and end-of-chapter problems.
Catalog no. K12982, March 2012, 578 pp. ISBN: 978-1-4398-6669-6, $119.95 / £76.99 Also available as an eBook
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Sensors & Signals Heart Rate Variability (HRV) Signal Analysis
Biosignal Processing Principles and Practices
Clinical Applications
Edited by
Edited by
Drexel University, Philadephia, Pennsylvania, USA
Markad V. Kamath and Adrian Upton,
Hualou Liang Joseph D. Bronzino
McMaster University, Hamilton, Ontario, Canada
Simsbury, Connecticut, USA
Mari A. Watanabe
University of Connecticut, Farmington, USA
St. Louis University, Missouri, USA
As biomedical data sets grow larger and more complicated, emerging signal processing methods to analyze and interpret these data have gained in importance. This book provides state-of-the-art coverage of contemporary methods in biosignal processing, with emphasis on brain signal analysis. The book discusses the process for biosignal analysis and explores a multivariate spectral analysis of EEG data using power, coherence, and second-order blind identification. It also reviews recent advances in causal influence measures. The book is destined to stimulate new research into developing cutting-edge computational methods, which will in turn accelerate laboratory discoveries into treatments for patients.
Written for graduate students and professionals, Heart Rate Variability (HRV) Signal Analysis reviews how minute variations in the beat-to-beat heart rate are regulated. It explores how these variations can be used as a window to understanding the central and peripheral mechanisms that modulate the autonomic nervous systems. Explaining how HRV is characterized through simple statistics and frequency analysis in both healthy human subjects and patients with a variety of diseases, the book provides examples for methods that require mathematical techniques. The authors cite a variety of real-life medical situations and offer extensive end-of-chapter references.
Contents: Heart Rate Variability: A Historical Perspective. Methodological Aspects of Heart Rate Variability Analysis. Methodological Aspects of Baroreflex Sensitivity Analysis. Arterial Blood Pressure Waveform Analysis and Its Applications in the Assessment of Vasovagal Syncope. Heart Rate Turbulence. PhaseRectified Signal Averaging: Methods and Clinical Applications. Heart Rate Variability Analysis for the Monitoring of Fetal Distress and Neonatal Critical Care. Heart Rate Variability and Blood Pressure Variability in Obstetrics and Gynecology. Effects of Exercise Training on Heart Rate Variability in Patients with Hypertension. Heart Rate Variability and Sleep. Heart Rate Variability in the Intensive Care Unit. Heart Rate Variability and Cardiovascular Dynamic Changes during Local Anesthesia. Effect of General Anesthesia on Heart Rate Variability. Heart Rate Variability in Functional Neurosurgery. Bariatric Surgery and Its Effects on Heart Rate Variability. Heart Rate Variability in Congestive Heart Failure. Heart Rate Variability Analysis in Ischemic Cardiomyopathy and Aortic Stenosis Patients. Respiratory Disease, Heart Rate, and Blood Pressure Variability: Effects of Pharmaceutical Compounds, Noninvasive Ventilation, and Physical Exercise. Effects of Spinal Cord Injury on Heart Rate Variability and Blood Pressure Variability. Autonomic Dysfunction in Stroke. The Significance of Heart Rate Variability in Patients with Epilepsy. Classification of Parkinson’s Disease Severity from Heart Rate Variability Analysis. Heart Rate Variability in Neuropsychiatric Disorders. Heart Rate Variability and Depression. Heart Rate Variability as a Measure of Depression and Anxiety during Pregnancy. Index.
Catalog no. K12259, September 2012, c. 532 pp. ISBN: 978-1-4398-4980-4, $149.95 / £95.00
Donald R. Peterson
Catalog no. K13271, October 2012, c. 201 pp. ISBN: 978-1-4398-7143-0, $99.95 / £63.99 Also available as an eBook
Biological and Medical Sensor Technologies Edited by
Krzysztof Iniewski CMOS Emerging Technologies, Inc., Vancouver, British Columbia, Canada
Edited by a pioneer in the area of advanced semiconductor materials, this book contains contributions from experts who explore the development and use of sensors in biological and medical applications. It covers advanced sensing and communications, modeling of DNA-derivative architecture, and the use of enzyme and quartz crystal microbalance-based biosensors. The book also addresses biosensors in human behavior measurement, sweat rate wearable sensors, and the future of medical imaging, including developments in spatial and spectral resolution of semiconductor detectors. Contributors discuss application of high-resolution CdTe detectors in gamma ray imaging and recent advances in positron emission tomography technology.
Catalog no. K13895, February 2012, 412 pp. ISBN: 978-1-4398-8267-2, $149.95 / £95.00 Also available as an eBook
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33
Sensors & Signals Healthcare Sensor Networks Challenges Toward Practical Implementation Edited by
Daniel Tze Huei Lai and Rezaul Begg Victoria University, Melbourne, Australia
Marimuthu Palaniswami University of Melbourne, Parkville, Victoria, Australia
From network deployment to secure monitoring, this book addresses the latest developments in healthcare sensor networks—medical monitoring devices implanted on the body or in the surrounding infrastructure. The text discusses fundamental concepts and provides examples of clinical applications, including sensors to monitor physical activity in children and wearable gait assistants for people with Parkinson’s. Each chapter details a separate challenge in design and implementation. Addressing topics ranging from sensor hardware and the demand for higher data bandwidth to portability and cost, the book highlights the key areas that require further research for HSNs to become a technological and commercially viable reality.
Catalog no. K11159, September 2011, 462 pp. ISBN: 978-1-4398-2181-7, $149.95 / £95.00
Biosensors and Molecular Technologies for Cancer Diagnostics Edited by
Statistical Evaluation of Diagnostic Performance Topics in ROC Analysis Kelly H. Zou, Aiyi Liu, Andriy I. Bandos, Lucila Ohno-Machado, and Howard E. Rockette Receiver Operating Characteristic (ROC) analysis is relevant to a wide variety of applications, including medical imaging, cancer research, epidemiology, and bioinformatics. Presenting innovative approaches in this field, this book examines monotone-transformation techniques in parametric ROC analysis, ROC methods for combined and pooled biomarkers, and Bayesian hierarchical transformation models. It also explores sequential designs and inferences in the ROC setting, predictive modeling, multireader ROC analysis, and free-response ROC (FROC) methodology. The book includes methods for estimation and comparison of diagnostic case characteristics. It also covers monotone transformation methods, binormality, and goodness-of-fit, and discusses clustered and multireader and multi-modality ROC and FROC analyses.
Catalog no. K10617, July 2011, 245 pp. ISBN: 978-1-4398-1222-8, $89.95 / £57.99 Also available as an eBook
Biomedical Sensors and Instruments Second Edition Tatsuo Togawa Waseda University, Tokorozawa, Saitama, Japan
Toshiyo Tamura
Keith E. Herold and Avraham Rasooly
Chiba University, Japan
P. Åke Öberg
Bridging the gap between research and clinical applications, this volume explores the use of biosensors as effective alternatives to the current methods for cancer diagnosis and detection. It describes the major aspects involved in detecting and diagnosing cancer, the basic elements of biosensors, and their applications in detection and diagnostics. It discusses several modes of electrochemical biosensors, such as potentiometric and amperometric biosensors. It also explores novel developments, including thermometric sensing and optomechanical cantilever-based technologies. Making biosensor technology more accessible to molecular biologists, oncologists, pathologists, and engineers, the book helps to advance the integration of this technology into mainstream clinical practice.
Linköping University, Sweden
Catalog no. K11937, May 2012, 844 pp. ISBN: 978-1-4398-4165-5, $169.95 / £108.00
Catalog no. 9078X, March 2011, 423 pp. ISBN: 978-1-4200-9078-9, $139.95 / £89.00
Also available as an eBook
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Biomedical sensors are essential instruments for acquiring many types of medical and biological data. From the underlying principles to practical applications, this updated handbook provides an easy-to-understand introduction to the various kinds. The state-of-the-art information presented includes discussions of biomedical sensors for measurements of pressure, flow, motion, temperature, heat flow, evaporation, biopotential, biomagnetism, and chemical quantities. The book’s organization makes it easy to find the best possible choice of sensors for each measurement situation. More than 300 updated figures and tables facilitate intuitive understanding and numerous examples of sensor applications demonstrate practical methods of research.
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Sensors & Signals Sensors for Chemical and Biological Applications Edited by
Manoj Kumar Ram Palm Harbor, Florida, USA
Venkat R. Bhethanabotla
Signal Processing in Magnetic Resonance Spectroscopy with Biomedical Applications
University of South Florida, Tampa, USA
Dževad Belki and Karen Belki
Supplying versatile, hands-on tools for professionals working in a broad array of disciplines, this volume presents detailed discussions of the potential of chemical and biochemical sensors in medical science, food quality, biological, and environmental applications. Examining the role of nanotechnology in sensor development, it explores how sensors confront challenges of chemical-bioterrorism through enhanced specificity, fast response times, and the ability to determine multiple hazardous substances. The book discusses the increasing importance of micro-electromechanical systems (MEMS) and acoustic wave (SAW) in sensor applications. It also includes examples of sensor usage, such as cholesterol monitoring, along with extensive references.
Addressing the critical need in clinical oncology for robust and stable signal processing in MRS, this book explores cutting-edge theory-based innovations for obtaining reliable quantitative information from MR signals for cancer diagnostics. By defining the natural framework of signal processing using the theory of quantum physics, it illustrates how advances in signal processing can optimize MRS. Applying the fast Padé transform (FPT) to several problems in oncology diagnostics, including ovarian, breast, and prostate cancer, the book examines the remarkable ability of the FPT to unambiguously quantify isolated, tightly overlapped, and nearly confluent resonances.
Catalog no. 3366, April 2010, 390 pp. ISBN: 978-0-8493-3366-8, $135.95 / £87.00
Karolinska Institute, Stockholm, Sweden
Catalog no. K10321, January 2010, 468 pp. ISBN: 978-1-4398-0644-9, $125.95 / £80.99 Also available as an eBook
Also available as an eBook
Semiconductor Radiation Detection Systems Edited by
Krzysztof Iniewski
Signals and Systems Analysis in Biomedical Engineering Second Edition
CMOS Emerging Technologies, Inc., Vancouver, British Columbia, Canada
Robert B. Northrop
This volume explores semiconductor radiation detection systems in a host of applications. An essential resource for a wide variety of professionals, the book addresses the state of the art in the design of semiconductor detectors and integrated circuits in the context of medical imaging using ionizing radiation. It includes new, exciting opportunities in x-ray detection, computer tomography (CT), bone dosimetry, and nuclear medicine applications such as PET and SPECT. In addition to medical imaging, the book explores other applications of semiconductor radiation detection systems in areas related to security, such as luggage scanning, dirty bomb detection, and border control.
The interdisciplinary field of biomedical engineering requires its practitioners to know and master not only engineering skills, but also a diversity of material in the biological sciences. This text helps biomedical engineering students and professionals strengthen their skills in the network of applied mathematics that ties together these diverse disciplines. Based on the author's 30 years’ experience in teaching as well as his personal research on neurosensory systems, this book, now in its second edition, provides a ready source of information on the specialized mathematical techniques most useful in describing and analyzing biomedical signals.
Catalog no. K10214, May 2010, 400 pp. ISBN: 978-1-4398-0385-1, $159.95 / £99.00
University of Connecticut, Storrs, USA
Catalog no. K10633, March 2010, 654 pp. ISBN: 978-1-4398-1251-8, $104.95 / £66.99
Also available as an eBook
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Sensors & Signals / BioMems Wireless Body Area Networks Technology, Implementation, and Applications Edited by
Mehmet R. Yuce Monash University, Victoria, Australia
Jamil Khan University of Newcastle, Callaghan, Australia
A comprehensive overview of the latest WBAN systems, technologies, and applications, this volume starts with the basic techniques involved in designing and building WBAN systems. It explains deployment issues and then moves into the application areas of WBAN. It discusses the development of hardware, signal processing algorithms, and wireless communication and network design for wearable and implantable body sensors used in WBAN applications. It also examines antenna design, propagation in and around the body, channel modeling, coexistence, and power management issues, which are critical design components for WBAN systems to achieve a successful hospital deployment.
BioMEMS Science and Engineering Perspectives Simona Badilescu and Muthukumaran Packirisamy Concordia University, Montreal, Canada
As technological advancements widen the scope of applications for biomicroelectromechanical systems (BioMEMS or biomicrosystems), the field continues to impact many aspects of life science operations and functionalities. Because BioMEMS research and development require the input of experts who use different technical languages and come from varying disciplines and backgrounds, scientists and students can avoid potential difficulties in communication and understanding only if they possess a skill set and understanding that enables them to work at the interface of engineering and biosciences.
Edited by
Keeping this duality in mind throughout, BioMEMS: Science and Engineering Perspectives supports and expedites the multidisciplinary learning involved in the development of biomicrosystems. Divided into nine chapters, it starts with a balanced introduction of biological, engineering, application, and commercialization aspects of the field. With a focus on molecules of biological interest, the book explores the building blocks of cells and viruses, as well as molecules that form the self-assembled monolayers (SAMs), linkers, and hydrogels used for making different surfaces biocompatible through functionalization. Because BioMEMS is an application-driven field, the book also highlights the concepts of lab-on-a-chip (LOC) and micro total analysis system (µTAS), along with their pertinence to emerging point-of-care (POC) and point-of-need (PON) applications.
Peter Wide
Features:
Orebro University, Sweden
• Provides a concise overview of BioMEMS principles • Incorporates modern applications • Covers fabrication techniques • Includes examples and problems in each chapter • Offers references, review questions, and case studies to aid comprehension
Catalog no. N10478, December 2011, 350 pp. ISBN: 978-981-4316-71-2, $149.95 / £95.00 Also available as an eBook
Artificial Human Sensors Science and Applications
As the elderly population increases, the importance of creating sophisticated information support to humans with limited sensing performance has also grown. This book discusses human and artificial sensing in conjunction with human perception capabilities (auditory, taste, smell, vision, and touch). It also discusses the fusion of this sensing information to find answers to questions such as how we can increase our human "fuzzy" decision capability (perception). The book presents intelligent new technologies that can enhance the natural sensing, perception, and mobility abilities of humans, allowing them to have healthier, more productive, safer lives.
Solutions manual available with qualifying course adoption
Catalog no. K10877, April 2011, 368 pp. ISBN: 978-1-4398-1699-8, $99.95 / £63.99 Also available as an eBook
Catalog no. N10431, March 2012, 220 pp. ISBN: 978-981-4241-58-8, $149.95 / £95.00 Also available as an eBook
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BioMems MEMS Packaging and Technology Edited by Analog Devices, Bangalore, Karnataka, India
Introduction to BioMEMS
Krzysztof Iniewski
Albert Folch
Vikas Choudhary
Redlen Technologies, Victoria, Canada
University of Washington, Seattle, USA
Written by international experts, MEMS: Packaging and Technology presents the latest research in the field of MEMS technology and the myriad applications it has enabled. The text covers automotive, consumer, communication, and medical applications of MEMs. Some of the applications discussed include high-precision on-chip integrated oscillators for reference generations, gyroscopes in cameras for optical image stabilization, radio communication, bioimplantable kidneys, and mobile phones. Other chapters address MEMS packaging and MEMS resonators, providing a fundamental understanding to enable novel applications. There is also a chapter outlining the historical evolution of current nano micro systems.
“The field has been waiting for a true textbook that provides a practical, historical, authoritative and comprehensive introduction to bioMEMS. It has finally arrived, courtesy of Albert Folch, complete with PowerPoint® lectures and thoughtful homework questions. I highly recommend it.”
Contents: Break-Through Technology. Microsystems to NanoMicrosystems: A Technological Break-Through. HfO2 Thin Film for MEMS Applications. Efficient ReliabilityBased Design Optimization for Microelectromechanical Systems. Hybrid Resonant Device. Piezoelectric Thin Films for MEMS Applications. MEMS Oscillators: From Emerging Technology to Commercial Revolution. Bulk Acoustic Wave (BAW) Gyroscopes. Energy Loss in MEMS Resonators. Trends in MEMS Packaging Technology. MEMS-Based Novel Applications. Designing VLSI Circuits and Systems with Nano-Electro Mechanical Relay. Bulk Acoustic Wave (BAW) Resonators for Mobile Communication Systems. A MEMS-Based Two-axis Gyroscope for OIS (Optical Image Stabilization) in Cameras. Passive Radio-Frequency Acoustic Sensors and Systems for Wired and Wireless Application. MEMS-Based Lamellar Grating FourierTransform Spectrometers. Resonance for MultiTransducer Systems. Nanoporous Membranes for Renal Replacement Therapy: The Implantable Bioartificial Kidney. Rigid Body Motions Capturing by Means of Wearable Inertial and Magnetic MEMS Sensors Assembly: An Application in Bio-Logging. Radio-Controlled Wireless MEMS Actuators and Applications.
Catalog no. K15054, January 2013, c. 400 pp. ISBN: 978-1-4665-1581-9, $149.95 / £95.00 Also available as an eBook
—David J. Beebe, University of Wisconsin–Madison
“A comprehensive, colorful textbook on the important field of bioMEMS. I will definitely recommend to my students!” —Albert van den Berg, University of Twente
“Dr. Folch’s book is a monumental achievement that brings an authoritative and comprehensive account to the rapidly growing, multidisciplinary field of bioMEMS. Many working scientists and engineers as well as students will find this book fascinating.” —Mehmet Toner, Helen Andrus Benedict Professor of Bioengineering, Harvard Medical School
With more than 400 color figures, Introduction to BioMEMS explains how miniaturization is revolutionizing biotechnologies and medicine, from microfluidics and tissue engineering to cell-based devices and implantable systems. All contents have been refined and tested by the author at the University of Washington. The book is an essential starting point for anyone embarking on research or study in this dynamic field.
Contents How Do We Make Small Things? Micropatterning of Substrates and Cells Microfluidics Molecular Biology on a Chip Cell-Based Chips for Biotechnology BioMEMS for Cell Biology Tissue Microengineering Implantable Microdevices Appendix Index
Catalog no. K10966, August 2012, c. 528 pp. ISBN: 978-1-4398-1839-8, $89.95 / £57.99 Also available as an eBook
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BioMems Also available as individual volumes Solid-State Physics, Fluidics, and Analytical Techniques in Micro- and Nanotechnology Marc J. Madou University of California, Irvine, USA
Fundamentals of Microfabrication and Nanotechnology Third Edition, Three-Volume Set Marc J. Madou University of California, Irvine, USA
"… offers the widest and yet the most detailed coverage of all essential and fundamental aspects of microfabrication and nanotechnology. The author has done an excellent and remarkable job in synthesizing such diverse material under a single umbrella." —Suman Chakraborty, IIT Kharagpur, India
"Once again, Professor Madou has made an incredible contribution to the MEMS/NEMS global community in writing this series of books." —Nico de Rooij, Director, Institute of Microengineering, EPFL, Switzerland
"… [the new 3-volume format] has the potential to become a ‘classic’ just like the one-volume predecessor… easy to read, and I found some concepts explained in ways I hadn’t heard before… Very ambitious, very informative, very good for teaching!" —Jorg P. Kutter, Technical University of Denmark
Thoroughly revised and updated, this perennial bestseller lays the foundation for comprehensive theoretical and practical understanding of MEMS and NEMS. Expanded to three volumes to reflect the substantial growth in the field, this edition features recent developments in nano- and micromanufacturing techniques, DNA and protein arrays, fluidics, photonics, and actuators. Illustrated in color throughout, the text includes end-of-chapter problems and worked-out examples—many culled from recent literature and the author’s own work. Ancillaries are available upon qualifying course adoption.
Save on the Set! Catalog no. 3180, August 2011, 1992 pp. ISBN: 978-0-8493-3180-0, $249.95 / £159.00
Volume I covers all aspects of solid-state physics behind nanotechnology and science. After exploring the rise of silicon, MEMS, and NEMS in a historical context, the text discusses crystallography, quantum mechanics, the band theory of solids, and the silicon single crystal. It concludes with coverage of photonics, the quantum hall effect, and superconductivity.
Catalog no. 55119, June 2011, 656 pp. ISBN: 978-1-4200-5511-5, $99.95 / £63.99 Also available as an eBook
Manufacturing Techniques for Microfabrication and Nanotechnology Marc J. Madou University of California, Irvine, USA
Volume II focuses on emerging trends in processes for fabricating MEMS and NEMS devices. It reviews different forms of lithography, subtractive material removal processes, and additive technologies, detailing those that differ the most from the miniaturization processes used to fashion ICs. The book covers both top-down and bottom-up fabrication processes and compares the merits of the different approaches.
Catalog no. 55194, June 2011, 670 pp. ISBN: 978-1-4200-5519-1, $99.95 / £63.99 Also available as an eBook
From MEMS to Bio-MEMS and Bio-NEMS: Manufacturing Techniques and Applications Marc J. Madou University of California, Irvine, USA
Volume III details manufacturing techniques applicable to bio-nanotechnology. After reviewing MEMS techniques, materials, and modeling, the author covers nanofabrication, genetically engineered proteins, artificial cells, nanochemistry, and self-assembly. He also discusses scaling laws in MEMS and NEMS, actuators, fluidics, and power and brains in miniature devices. He concludes with coverage of various MEMS and NEMS applications.
Catalog no. 5516X, June 2011, 650 pp. ISBN: 978-1-4200-5516-0, $99.95 / £63.99 Also available as an eBook
Solutions manual, PowerPoint lecture slides, and electronic figures available for all volumes upon qualifying course adoption
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NEW!
Assistive Technology Assessment
Edited by
Stefano Federici University of Perugia, Italy
Marcia Scherer Institute for Matching Person & Technology, Webster, New York, USA
H A N D B O O K The process of matching a person who has a disability with the most appropriate assistive technology requires a series of assessments, typically administered by multidisciplinary teams at specialized centers for technical aid. Assistive Technology Assessment Handbook helps assistive technology experts perform assessments that more effectively connect the person and the technology. Emphasizing the well-being of the individual with a disability, the book proposes an ideal model of the assistive technology assessment process and outlines how this model can be applied in practice internationally. The book synthesizes information scattered throughout the international literature, focusing on aspects that are particularly representative or innovative. It also addresses the challenges posed by the variety of health and social care systems and the different ways that individuals who need aid are defined. Edited by Stefano Federici and Marcia J. Scherer— internationally renowned leaders in the field of assistive technology assessment—this cross-cultural handbook guides readers in matching the person and the appropriate assistive technology, offering a framework for future practice and research.
Contents: Section I: The Assistive Technology Assessment Model and Basic Definitions: Assessing Individual Functioning and Disability. Measuring Individual Functioning. Measuring the Assistive Technology Match. The Assessment of the Environments of AT Use: Accessibility, Sustainability, and Universal Design. Measuring the Impact of AT on Family Caregivers. Section II: Assessment Professionals: Working on the Multidisciplinary Team: The Cognitive Therapist. The Special Educator. The Psychologist. The Psychotechnologist: A New Profession in the Assistive Technology Assessment. The Optometrist. The Occupational Therapist: Enabling Activities and Participation Using Assistive Technology. Pediatric Specialists in Assistive Solutions. The Geriatrician. Role of Speech–Language Pathologists in Assistive Technology Assessments. Section III: Assistive Technology Devices and Services: Systemic User Experience. Web Solutions for Rehabilitation and Daily Life. Brain–Computer Interfaces: The New Landscape in Assistive Technology. New Rehabilitation Opportunities for Persons with Multiple Disabilities Through the Use of Microswitch Technology. Methods and Technologies for Leisure, Recreation, and an Accessible Sport. Index.
Catalog no. K11756, March 2012, 484 pp., ISBN: 978-1-4398-3865-5, $139.95 / £82.00 Also available as an eBook
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