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Contents Frontiers in Neuroscience & Neuroengineering Series ............................................3 Clinical Neuroscience................................................16 Neuroscience ............................................................23 Lab Animal Science ..................................................27 Page 4
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Frontiers in Neuroscience & Neuroengineering Series New!
Alzheimer's Disease Targets for New Clinical Diagnostic and Therapeutic Strategies Edited by
Renee D. Wegrzyn PhD, Adlyfe, Inc., Rockville, Maryland, USA
Alan S. Rudolph PhD, MBA, Center for Neuroengineering, Duke University, Durham, North Carolina, USA
In recent years, a tremendous amount of effort has been focused on better understanding the fundamentals of Alzheimer’s disease (AD) to facilitate early and accurate diagnosis and appropriately targeted therapeutic treatments. Alzheimer’s Disease: Targets for New Clinical Diagnostic and Therapeutic Strategies provides a detailed synopsis of the current state of the art of diagnostics and therapeutics and identifies emerging technologies and molecules that show promise in the management and treatment of AD. With contributions from experts drawn from academia, clinical practice, and the biotechnology and pharmaceutical industries, the book explores: • The basis of AD and the role of Aβ oligomers in development of disease • Existing and emerging in vitro biomarker-based methodologies for the diagnosis of AD, focusing on genetic, biochemical, and conformational strategies • In vivo imaging diagnostic approaches • Evolving diagnostic criteria, health regulatory guidelines, biomarkers in clinical trials, and available and emerging therapies • Recent progress in small-molecule diseasemodifier drug discovery efforts for AD, specifically in the areas of Aβ, tau, and emerging neuroprotective/neurorepair approaches • How a case study of AD raises issues regarding clinical and pathologic criteria, risk factors, and the amyloid hypothesis • The molecular conformational factors that govern the pathogenicity of aggregating proteins, and how these factors could represent new targets for disease-modifying therapies • The latest epidemiological, pathological, biochemical, and behavioral studies that may shed some light on the risk of developing AD and similar dementias after traumatic brain injury
New!
The Neurobiological Basis of Suicide Edited by
Yogesh Dwivedi University of Illinois at Chicago, USA
With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding the pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also present a promising approach to developing more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they are often weak predictors and can be of less clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. This volume focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.
Features: • Presents cutting-edge research on the neurobiology of suicide • Covers the rapidly growing field of suicide research, including gene expression, microRNA, genetics, epigenetics, and the molecular basis of suicide • Discusses how recent neurobiological approaches may transform suicide treatment modalities • Addresses neurochemical/neuroanatomical/ neuropathological approaches, genetic approaches, intermediate endophenotypes, and epigenetic approaches
Catalog no. K11764, June 2012, 482 pp. ISBN: 978-1-4398-3881-5, $149.95 / £95.00 Also available as an eBook
Examining current hypotheses and suggesting possible new approaches to therapeutic clinical applications, this volume paves the way for a robust pipeline of therapeutics to combat not only AD, but a whole host of other neurodegenerative diseases.
Catalog no. K11334, April 2012, 298 pp. ISBN: 978-1-4398-2708-6, $149.95 / £95.00 Also available as an eBook
For more information and complete contents, visit www.crcpress.com
3
Frontiers in Neuroscience & Neuroengineering Series Forthcoming!
Dopamine – Glutamate Interactions in the Basal Ganglia
Transcranial Brain Stimulation Edited by
Carlo Miniussi University of Brescia-IRCCS FBF, Italy
Edited by
Walter Paulus
University of Cambridge, UK
Georg-August University of Gottingen, Germany
The basal ganglia are involved in complex brain functions and are implicated in numerous neurological and psychiatric disorders. At the heart of both function and dysfunction of basal ganglia circuits is the interaction of dopamine and glutamate. Improved labeling, imaging, recording, and genetic manipulation approaches have yielded new information on how dopamine and glutamate interact to generate the circuit activity underpinning basal ganglia function. This volume presents current insights on individual neurons and synapses, detailed circuit analysis, and learning and action functions of the basal ganglia. It also discusses compromised dopamine–glutamate interaction in various disorders of basal ganglia function.
Paolo M. Rossini University Campus Bio Medico, Roma, Italy
Recent years have seen the introduction and rapid development of non-invasive brain stimulation techniques, such as transcranial magnetic stimulation (TMS) and transcranial electrical stimulation. Transcranial Brain Stimulation reviews these recent advances made in the understanding of brain stimulation techniques. The text presents the wide range of possible brain stimulation applications in combination with neuroimaging and discusses what new information can be gained from using this technique on the dynamics of brain functions, hierarchical organization, and effective connectivity. With this timely resource, the authors aim to make a substantial impact on many areas of clinical and basic neuroscience.
Catalog no. 88793, December 2011, 284 pp. ISBN: 978-1-4200-8879-3, $149.95 / £95.00 Also available as an eBook
Contents: Basic Aspects. Methodological Aspects of TMS (Including Coils Design). Physiological Basis of TMS (Including Waveform and Current Direction Induced Effects etc.). Effects of Electric and Magnetic Fields: Study in Animal Models and In Slice. Methodological Aspects and Physiological Basis and of tES (i.e., tDCS; tRNS; tACS). Biophysical Foundations: From Neuronal to Current Distribution Model of TMS and tES. Patterned Protocols of TMS. Motor Cortical and Corticospinal Measures in Health and Disease. Brain Stimulation, Functional Neuroanatomy of Cortico Connectivity and Mechanisms of Neuroplasticity. Understanding Homeostatic Plasticity. Safety ofTMS and tES. Biology. Brain Stimulation and Molecular Markers. Imaging-Brain Mapping. Non Invasive Brain Stimulation and Neuroimaging (Including Navigated Brain Stimulation). Perception and Cognition. TMS tES in Perception and Cognitive Functions. Therapeutic Applications. TMS - tES Therapeutic Applications in Psychiatry. TMS - tES Therapeutic Application in Neurology.
Catalog no. K13512, December 2012, c. 464 pp. ISBN: 978-1-4398-7570-4, $159.95 / £99.00 Also available as an eBook
Susan Jones
Astrocytes Wiring the Brain Edited by
Eliana Scemes and David C. Spray Albert Einstein College of Medicine, Bronx, New York, USA
Astrocytes play diverse roles in central nervous system (CNS) function and dysfunction, and the connections that the astrocyte makes with other cells of the brain are essential for a variety of important neural tasks. This volume emphasizes cellular connections and surveys the most current findings on astrocyte activity. The book identifies major astrocyte biomarkers and describes how they define the different connectivity domains. It examines the role of these connections and explains how their function can be manipulated and how dysfunction of the connectivity leads to aberrant brain performance. The final section explores the alterations of glia that have been observed in specific diseases of the brain.
Catalog no. K11240, November 2011, 440 pp. ISBN: 978-1-4398-2584-6, $149.95 / £95.00 Also available as an eBook
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Frontiers in Neuroscience & Neuroengineering Series Neurobiology of Depression Edited by
Francisco López-Muñoz
The Neural Bases of Multisensory Processes
University of Alcalá, Madrid, Spain and Camilo José Cela University, Madrid, Spain
Edited by
Cecilio Álamo
CIBM, Lausanne, Switzerland
University of Alcalá, Madrid, Spain
Major depressive disorders have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways hold promise as new therapeutics for depression. With the collaboration of the most prestigious international specialists in biochemistry, molecular biology, genomics, psychiatry, psychology, and pharmacology, Neurobiology of Depression discusses the nature of the central nervous system circuits responsible for the modifications of neuronal functioning that lead to depression. The book begins by discussing animal, neurophysiological, and neuropsychological models of depression as well as neural foundations. It explores genetic factors that contribute to depression and describes the effect of monoaminergic systems in the central nervous system. Next, the book profiles the rise of psychopharmacology in the treatment of depression and the research into serotonin and monoamine reuptake inhibitors. It examines the role of the glutamatergic, endocannabinoid, and opioid systems in the pathophysiology of mood disorders, as well as the effect of biological rhythms on the human body. Later chapters review the role of CRF-related ligands, CRF receptors, HPA axis activity, and glucocorticoid receptors in the regulation of the stress response and depression. They also describe cytokine modulation of molecular mechanisms. They examine the role of neuropeptide Y, nitric oxide, beta-arrestins, BDNF, and phosphodiesterases, and discuss the use of tachykinin antagonists in treatment. Finally, they analyze the neurobiological basis for the development of new antidepressant agents. Exploring myriad aspects of a disease that plagues a large percentage of the population worldwide, this volume captures the state of the science of this debilitating disorder, facilitating further research and discovery.
Catalog no. K11746, September 2011, 522 pp. ISBN: 978-1-4398-3849-5, $149.95 / £95.00 Also available as an eBook
Micah M. Murray Mark T. Wallace Vanderbilt Brain Institute, Nashville, Tennessee, USA
It has become accepted in the neuroscience community that perception and performance are quintessentially multisensory by nature. Using the full palette of modern brain imaging and neuroscience methods, this volume details current understanding in the neural bases for these phenomena as studied across species, stages of development, and clinical statuses. The book examines anatomy and neurophysiological bases and how multisensory stimuli can dramatically change the encoding processes for sensory information. It also discusses combinatorial principles and modeling, development and plasticity, clinical manifestations, how perception and action are affected by altered sensory experience, and attention and spatial representations.
Catalog no. K10614, August 2011, 809 pp. ISBN: 978-1-4398-1217-4, $149.95 / £95.00 Also available as an eBook
Neurobiology of Sensation and Reward Edited by
Jay A. Gottfried Northwestern University, Chicago, Illinois, USA
A comprehensive systems overview of sensory and reward processing in the brain, this book explores what reward processing can teach us about the senses and what sensory processing can teach us about reward. In examining this neurobiological interface, the book reveals how the instrinsic properties of sensory systems effectively define and constrain the ambitions of reward-related processing in human and non-human brains. With contributions from leading investigators in the fields of sensation and reward, the text injects the “sensory” back into the study of reward processing, and the "rewarding" back into the study of sensory processing.
Catalog no. 67265, March 2011, 466 pp. ISBN: 978-1-4200-6726-2, $149.95 / £95.00 Also available as an eBook
For more information and complete contents, visit www.crcpress.com
5
Frontiers in Neuroscience & Neuroengineering Series Neurobiology of Huntington’s Disease
The Somatosensory System
Applications to Drug Discovery Edited by
Deciphering the Brain's Own Body Image
Donald C. Lo
Edited by
Duke University Medical Center, Durham, North Carolina, USA
Randall J. Nelson
Robert E. Hughes Buck Institute for Age Research, Novato, California, USA
Highlighting advances in the discovery and development of new drug therapies for neurodegenerative disorders, this volume focuses on the many aspects of the research on drugs to treat Huntington's disease. It discusses genetics, genomics, and proteomics, and the latest in high-throughput and high-content screening. The authors provide introductory background as well as highly sophisticated information on current and future directions of research. Exploring the interplay between academic and industrial research, the investment community, and non-profit contributors, the book also examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage.
University of Tennessee, Memphis, USA
Exploring new and past research in the understanding of how the brain deals with its own body image, The Somatosensory System: Deciphering the Brain's Own Body Image provides a review of pertinent literature and offers comprehensive descriptions of technical approaches. The material includes new frameworks for the conceptualization of the system's representations, scientific and clinical applications that stem from these approaches based on the new concepts, and a discussion of tools used to study the interface of the brain and the body.
Features:
Edited by
• Presents the neurophysiological basis of touch and tactile discrimination deficit • Describes methods to quantify large-scale brain activity in behaving animals • Discusses the neurophysiological basis of plastic neuronal reorganization in adult animals • Provides computational strategies for sensorimotor integration of the mammalian brain • Includes algorithms for the design and implementation of haptic interfaces and tactile displacement
Cynthia M. Kuhn
Contents:
Duke University Medical Center, Durham, North Carolina, USA
Central Organization of the Body Image
George F. Koob
The Periphery and its Contribution to the Body Image
Catalog no. 9000, July 2010, 338 pp. ISBN: 978-0-8493-9000-5, $159.95 / £99.00 Also available as an eBook
Advances in the Neuroscience of Addiction
The Scripps Research Institute, La Jolla, California, USA
Featuring contributions from leading experts, this book presents an excellent overview of the available and emerging approaches used to investigate the neurobiological mechanisms of drug addiction. Discussion includes the behavioral strategies and characteristics of addiction as well as mechanistic approaches to understanding the underlying neurobiology. The authors provide information from mathematical models, model organisms, animal models, and experiments conducted in humans. They deliver a comprehensive introduction to the methodologies of the field for students and beginning researchers and an essential reference source for established investigators.
Orientation and the Body Image Learning and Attention Applications for Deciphering the Code Models of the Body Image Changing the Body Image
Catalog no. 2336, November 2001, 424 pp. ISBN: 978-0-8493-2336-2, $169.95 / £108.00 Also available as an eBook
Catalog no. 7391, April 2010, 238 pp. ISBN: 978-0-8493-7391-6, $145.95 / £93.00 Also available as an eBook
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Frontiers in Neuroscience & Neuroengineering Series
Serotonin Receptors in Neurobiology
Brain Aging Models, Methods, and Mechanisms
Edited by
Edited by
David R. Riddle
Amitabha Chattopadhyay
Wake Forest University, WinstonSalem, North Carolina, USA
Center for Cellular & Molecular Biology, Hyderabad, India
Bringing together critical studies of brain aging in animal models and insights from human brain imaging, this text focuses on fundamental age-related changes in the brain. Offering significant depth and breadth of coverage, it provides an overview of structural and functional changes at the molecular, systems, and cognitive levels. Written by pioneering researchers, it reviews unbiased methods for quantifying changes and stereological methods for clarifying the extent and nature of age-related neurological changes. It also explores the distinct methodological challenges inherent in investigating the aging nervous system.
Modulating mood, appetite, sexual activity, body temperature, and sleep, serotonin has implications in numerous disease states, including depression, anxiety, social phobia, schizophrenia, obsessive-compulsive disorder, and panic disorder. A comprehensive book on the subject from a multidisciplinary perspective, Serotonin Receptors in Neurobiology is among the first books to be published after serotonin receptor knock-out studies. With contributions from leading experts in their fields, this book covers a range of topics from contemporary techniques in receptor research to fundamental interactions of the 5-HT receptors with the lipid bilayer to behavioral studies.
Catalog no. 3818, April 2007, 408 pp. ISBN: 978-0-8493-3818-2, $169.95 / £108.00 Also available as an eBook
Features:
Duke University Medical Center, Durham, North Carolina, USA
• Assesses the current understanding of physiologically important 5-HT1AR-mediated signaling cascades • Unravels poorly understood processes that have yet to be delineated through further experiments • Describes a technique to directly image vesicular setotonin in live neurons • Explores methods for the quantitative measurement of the intracellular cAMP concentration in living cells with good spatial and temporal resolution • Elucidates the emerging roles for calmodulin as a regulator of 5-HT receptor function • Describes recent work suggesting that calmodulin may be a so-called RIP (receptor-interacting protein) that binds to and modifies the functions of G protein-coupled 5-HT receptors
“ … the most advanced compilation of work in this area to date.”
Catalog no. 3977, May 2007, 224 pp. ISBN: 978-0-8493-3977-6, $165.95 / £105.00
TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades Edited by
Wolfgang B. Liedtke
— Anticancer Research
Also available as an eBook
TRP channels have been shown to respond to a wide range of stimuli from both within and outside the cell. This volume highlights progress in the elucidation of the in vivo function of the various members of the TRP ion channel family. It covers the role of TRP channels in sensory transduction and signaling cascades and discusses the development of novel pharmaceuticals for the treatment of cancer, heart disease, and immune system dysfunctions.
Catalog no. 4048, September 2006, 467 pp. ISBN: 978-0-8493-4048-2, $179.95 / £115.00 Also available as an eBook
For more information and complete contents, visit www.crcpress.com
7
Frontiers in Neuroscience & Neuroengineering Series Neural Plasticity and Memory From Genes to Brain Imaging
Neural Prostheses for Restoration of Sensory and Motor Function
Edited by
Edited by
Federico BermúdezRattoni
John K. Chapin
National University of Mexico, Mexico City, Distrito Federal
This volume provides a multidisciplinary review of research being conducted on the neurobiology of memory. It examines the synaptic communication elements identified as being susceptible to modification through the accumulation of experience. It also explains how cell circuitry is modulated and ultimately modified by neurotransmitters and hormones during the process of acquiring, consolidating, and retrieving information. In each chapter, researchers present findings and explain their innovative methodologies. The text also addresses current memory studies involving human brain imaging.
Catalog no. 9070, April 2007, 368 pp. ISBN: 978-0-8493-9070-8, $169.95 / £108.00 Also available as an eBook
State University of New York Health Science Center, Brooklyn, USA
Karen A. Moxon Drexel University, Philadelphia, Pennsylvania, USA
While the creation of a bionic man may still be far into the future, neural prostheses are rapidly becoming viable for patients with injury or disease of the nervous system. This book explores the recent advances in neural prosthetic techniques and applications. It details some of the most successful sensory and motor prosthetic devices available and then examines the growing field of brain-implantable devices for the control of artificial prosthetic devices or neural prosthetics.
Catalog no. 2225, September 2000, 312 pp. ISBN: 978-0-8493-2225-9, $169.95 / £108.00 Also available as an eBook
Methods for Neural Ensemble Recordings
In Vivo Optical Imaging of Brain Function
Second Edition
Second Edition
Edited by
Edited by
Miguel A. L. Nicolelis
Ron D. Frostig
Duke University Medical Center, Durham, North Carolina, USA
University of California, Irvine, California, USA
This second edition of a bestseller distills the current state of the science and provides the nuts and bolts foundation of the methods involved in this rapidly growing science. With contributions from pioneering researchers, it discusses microwire array design for chronic neural recordings, new surgical techniques for chronic implantation, microelectrode microstimulation of brain tissue, multielectrode recordings in the somatosensory system, and recordings from the central gustatory-reward pathways. It also explores the use of Brain-Machine Interface to restore neurological function and proposes conceptual and technical approaches to human neural ensemble recordings in the future.
Reflecting continual development in this emerging area, this volume reaches across disciplines to review a variety of noninvasive optical techniques used to study activity in the living brain. Leading authorities from such diverse areas as optical hardware, cognitive behavior, and neuroscience present a host of perspectives that range from a single neuron to large assemblies of neurons several million strong, captured at various temporal and spatial resolutions. Introducing techniques that were unavailable just a few years ago, the book describes their theory, setup, and analytical methods and provides examples that highlight the advantages of each particular method.
Catalog no. 7046, December 2007, 296 pp. ISBN: 978-0-8493-7046-5, $169.95 / £108.00
Catalog no. 76841, May 2009, 428 pp. ISBN: 978-1-4200-7684-4, $159.95 / £99.00 Also available as an eBook
Also available as an eBook
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Frontiers in Neuroscience & Neuroengineering Series Fat Detection Taste, Texture, and Post Ingestive Effects Jean-Pierre Montmayeur Centre des Sciences du Hout, Dijon, France
DNA Arrays Technologies and Experimental Strategies Edited by
Johannes le Coutre
Elena V. Grigorenko
Nestlé Research Center, Lausanne, Switzerland
Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts,
Taking a multidisciplinary approach, this volume sheds new light on critical concerns regarding dietary fat and its relation to obesity. Going far beyond the well-known concerns, it offers new scientific data on the many aspects of fat, including psychological, behavioral, genetic, and physiological factors that contribute to its desirability, perception, intake, and impact on human health. Bringing together cross-disciplinary research, it includes information on genetic predisposition, neural imaging, and endocrine impacts on metabolism. It also provides a progressive integrated view on fat taste, fat preference, and nutrition at the molecular level.
A quantum leap in technology took place a few years ago with the introduction of cDNA arrays that have been developed in response to the need for simultaneous analysis of the patterns of expression of thousands of genes. DNA Arrays: Technologies and Experimental Strategies offers a broad view of different aspects of this rapidly developing technology, including oligonucleotide and electrochemical arrays. Distinguished investigators from academia and industry provide up-to-date insights into methodological fundamentals of construction of DNA arrays, optimization of hybridization conditions, the use of expression data in bioinformatics, software tools, and the application of microarray technology for drug discovery.
Catalog no. 67753, September 2009, 643 pp. ISBN: 978-1-4200-6775-0, $159.95 / £99.00 Also available as an eBook
Contents: Technology Development for DNA Chips
The Role of the Nucleus of the Solitary Tract in Gustatory Processing Edited by
Robert M. Bradley University of Michigan, School of Dentistry, Ann Arbor, USA
The nucleus of the solitary tract (NST) provides an essential brainstem relay for three cranial nerves, coordinating highly complex sensory information. While other functions of the NST have received attention, its role in gustatory processing has received little. This work is the first reference on the NST devoted exclusively to gustatory processing. Compiling past and current research into a single volume, it documents the anatomy of the NST, explores the properties of synaptic transmitters and neurons in the NST, compares the gustatory NST with the caudal NST, and considers the challenges involved in identifying NST neural circuits.
A System Approach to Manufacturing and Analyzing DNA Arrays Nylon Platform: Pros and Cons Electrochemical Detection of Biomolecules Oligonucleotide Array Technologies for Gene Expression Profiling DNA Microarrays in Neurobiology Data Management in Microarray Fabrication, Image Processing, and Data Mining Zeroing In on Essential Gene Expression Data Application of High-Density Nylon Arrays for Analysis of Gene Expression in Different Experimental Models Supplier List List of Web Sites Related to DNA Arrays
Catalog no. 2285, December 2001, 184 pp. ISBN: 978-0-8493-2285-3, $169.95 / £108.00 Also available as an eBook
Catalog no. 4200, October 2006, 158 pp. ISBN: 978-0-8493-4200-4, $179.95 / £115.00 Also available as an eBook
For more information and complete contents, visit www.crcpress.com
9
Frontiers in Neuroscience & Neuroengineering Series Translational Pain Research From Mouse to Man Edited by
The Primate Visual System
Lawrence Kruger
Edited by
University of California, Los Angeles, USA
Jon H. Kaas and Christine E. Collins
Alan R. Light University of Utah, Salt Lake City, USA
Vanderbilt University, Nashville, Tennessee, USA
Advances in molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its therapeutic applications. This book brings together recent advances in modern neuroscience, genetic studies in mice and humans, and the results of clinical trials. It examines rodent models for pain associated with bone cancer, osteoarthritis, and cardiac episodes. It covers the cloning of highly specific receptors and the analysis of modular molecular mechanisms relevant to painful neuropathies. The book also considers the trend toward translational research in the commercial pharmaceutical industry.
"Chapters are well written and offer clear examples of complicated system interconnectivity."
Catalog no. K10609, November 2009, 432 pp. ISBN: 978-1-4398-1209-9, $174.95 / £112.00 Also available as an eBook
—Contemporary Topics in Laboratory Animal Science
Exploring the neural behavior of visuomotor processing in the primate brain, this book discusses the anatomical and functional organization of the primate visual system and proposes new directions for research. It describes state-of-the-art methods for investigating the visual system and examines how it is formed during development. It considers a range of topics concerning various primates and covers processing from the eye to neural codes for action, and from basic perception to memory.
Catalog no. 1243, July 2003, 440 pp. ISBN: 978-0-8493-1243-4, $169.95 / £108.00 Also available as an eBook
Methods of Behavior Analysis in Neuroscience
The Neurobiology of Olfaction
Second Edition Edited by
Edited by
Jerry J. Buccafusco Medical College of Georgia, Augusta, USA
Anna Menini
A comprehensive reference for the most well-studied behavioral approaches in animal subjects, this book examines disease effects and therapeutic treatments. The second edition features material on the relevance of transgenic mouse models for Alzheimer’s disease, behavioral methods for assessing the cognitive impairment associated with major psychotic disorders, the revival of the scopolamine reversal model for assessing the clinical relevance of new AD drugs, and new approaches for assessing cognitive impairment in aged mice. Each chapter presents theoretical background, methodology, and data interpretation.
A comprehensive overview of the current status of knowledge and research on olfaction, this volume takes an interdisciplinary approach to include content from genetics to behavior and from nematodes to humans. It offers chapters on discoveries in odor coding from the olfactory epithelium to the cortical centers, and in neurogenesis in the olfactory epithelium and the olfactory bulb. Written by a top researcher in the field, each subject-specific chapter provides an extensive list of reviews and original articles for students and scientists interested in further reading.
S.I.S.S.A, Trieste, Italy
Catalog no. 52349, October 2008, 360 pp. ISBN: 978-1-4200-5234-3, $165.95 / £105.00
Catalog no. 71971, November 2009, 448 pp. ISBN: 978-1-4200-7197-9, $174.95 / £112.00 Also available as an eBook
Also available as an eBook
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Frontiers in Neuroscience & Neuroengineering Series
Neuroproteomics
Neural Plasticity in Adult Somatic Sensory-Motor Systems
Edited by
Edited by
Oscar Alzate
Ford F. Ebner
University of North Carolina, Chapel Hill, USA
Vanderbilt University, Nashville, Tennessee, USA
With an extensive background in mathematics and physics, editor Dr. Oscar Alzate exemplifies the newest generation of biological systems researchers. In this volume, he organizes an overview of neuroproteomics that is practical and progressive. Approaches discussed include mass spectrometry, electrophoresis, chromatography, surface plasmon resonance, protein arrays, immunoblotting, computational proteomics, and molecular imaging. Leading researchers detail the principles, approaches, and difficulties of the techniques, showcasing the questions that neuroproteomics can answer as well as those it raises. The book Includes research that is redefining our understanding of Parkinson’s, Alzheimer’s and other neurological and mental diseases.
Synthesizing current information about sensorymotor plasticity, this book describes the dynamic processes that occur in somatic sensory-motor cortical circuits or somatic sensory pathways to the cortex due to experience, learning, or damage to the nervous system. It emphasizes changes in the cortex that are linked to changes in movement or behavior, and demonstrates the potential for direct brain-based interventions to improve the quality of life for people with sensory-motor disabilities. The book includes studies that document the dynamic changes in system properties that occur with normal experience or in recovery from brain damage.
Catalog no. 76256, October 2009, 354 pp. ISBN: 978-1-4200-7625-7, $174.95 / £112.00
Also available as an eBook
Catalog no. 1521, May 2005, 296 pp. ISBN: 978-0-8493-1521-3, $169.95 / £108.00
Also available as an eBook
New Concepts in Cerebral Ischemia
Methods in Insect Sensory Neuroscience
Edited by
Edited by
Rick C. S. Lin
Thomas A. Christensen
University of Mississippi Medical Center, Jackson, USA
University of Arizona, Tucson, USA
Providing a detailed description of the techniques and theories employed in both basic and clinical research, this volume delineates the mechanisms underlying neuronal damage induced by ischemia. It covers methods to elucidate the pathogenesis of ischemia, technologies used in the design of specific strategies to protect neurons from further injury, and new approaches to treating patients with acute ischemic episodes. It includes methods and therapeutic approaches for neuronal protection against acute and chronic ischemic episodes and describes new animal models for ischemia research including the application of transgenic animals.
Written by recognized experts in sensory biology, this volume synthesizes the latest information and reviews the most current methods for studying the specialized sensory systems of insects. Bridging the gap between experimentalists and theorists, the book explores anatomical pathway tracing, electrophysiological recording, genetic and pharmacological manipulations, computational modeling, and behavioral observations. Each chapter discusses the most challenging questions facing sensory neuroscience today and provides a unique synopsis of the developments that are driving the field forward.
Catalog no. 0328, December 2001, 328 pp. ISBN: 978-0-8493-0119-3, $169.95 / £108.00
Catalog no. 2024, December 2004, 464 pp. ISBN: 978-0-8493-2024-8, $169.95 / £108.00 Also available as an eBook
Also available as an eBook
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11
Frontiers in Neuroscience & Neuroengineering Series Functional and Neural Mechanisms of Interval Timing
Methods in Alcohol-Related Neuroscience Research Edited by
Edited by
Yuan Liu
Warren H. Meck
National Institute of Neurological Disorders & Stroke, Bethesda, Maryland, USA
Duke University, Durham, North Carolina, USA
"[A] thorough and richly informative book." —Journal of Clinical Psychiatry
This critically praised work synthesizes the current knowledge of animal behavior and human cognition as related to both technical and theoretical approaches in the study of duration discrimination. Chapters written by the foremost experts in the field integrate the fields of time quantum and psychophysics, rhythmic performance and synchronization, as well as attentional effort and cognitive strategies through the linkage of time as information in brain and behavior.
Catalog no. 1109, March 2003, 600 pp. ISBN: 978-0-8493-1109-3, $179.95 / £115.00 Also available as an eBook
David M. Lovinger Laboratory of Integrative Neuroscience, NIAAA, Nashville, Tennessee, USA
Written by a panel of experts, this volume provides an overview of the effects of alcohol on the brain, offering technical guidance for investigators doing research at the molecular, cellular, systems, and behavioral levels. These techniques include a wide variety of approaches, ranging from gene mapping and examination of molecular interactions of alcohol at the sub-cellular level, to recording of neural activities in freely-behaving animals, and imaging alcohol effects on the living human brain.
Catalog no. 0347, February 2002, 416 pp. ISBN: 978-0-8493-0203-9, $169.95 / £108.00 Also available as an eBook
Primate Audition
Methods in Chemosensory Research
Ethology and Neurobiology
Edited by
Edited by
Asif A. Ghazanfar
Sidney A. Simon and Miguel A. L. Nicolelis
Princeton University, New Jersey, USA
Duke University Medical Center, Durham, North Carolina, USA
Bridging the epistemological gap between primate ethologists and auditory neurobiologists, this book brings together leading scientists who apply their methods to a variety of issues related to primate vocal behavior and the neurobiology of the primate auditory system. The synthesis of ethological and neurobiological approaches to primate vocal behavior will yield a rich understanding of the acoustic and neural bases of primate audition and shed light on the evolutionary precursors to speech.
Exploring the field of neuronal chemoreception, this text describes new molecular, electrophysiological, engineering, genetic, behavioral, psychophysical, and imaging techniques that have recently been adapted to investigate the basic neuronal mechanisms underlying chemoreception. The contributors specialize in olfaction, gustation, baroreception, and chemical irritation caused by environmental pollutants. They provide novel methods to investigate all aspects of taste and olfaction, ranging from the molecular level to the investigation of individual cell taste and olfactory epithelia.
Catalog no. 0956, August 2002, 336 pp. ISBN: 978-0-8493-0956-4, $179.95 / £115.00 Also available as an eBook
Catalog no. 2329, September 2001, 552 pp. ISBN: 978-0-8493-2329-4, $169.95 / £108.00 Also available as an eBook
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Frontiers in Neuroscience & Neuroengineering Series Animal Models of Cognitive Impairment Methods in Pain Research
Edited by
Edward D. Levin
Edited by
Duke University Medical Center, Durham, North Carolina, USA
Lawrence Kruger
Jerry J. Buccafusco
University of California, Los Angeles, USA
Medical College of Georgia, Augusta, USA
" … an important book for neuroscience libraries and laboratories involved in the study of pain. 4 Stars!” —Doody's Notes
Addressing a rapidly growing area of neuroscience, this volume surveys the methods used to study a reaction or "sensory report" in humans that can only be inferred by indirect means in animal or tissues studies. The book examines techniques used in studying pain, including gene linkage, brain imaging methods, the use of transgenic rodent models, painful sensory neuropathy models, and more. It also covers conventional methods of pain study, including anatomical and electophysiological techniques.
Catalog no. 0035, June 2001, 336 pp. ISBN: 978-0-8493-0035-6, $179.95 / £115.00
Animal models of cognitive function—including learning, memory, and attention—are critical for determining the neurobehavioral basis for cognition and for the development of new therapeutic treatments for cognitive impairment. This volume integrates molecular and neurochemical approaches in translational models with behavioral and clinical applications. The text also discusses current research on genetic, lesion, pharmacological toxicant, and aging models. It explores the significance of this research to the treatment of various addictions and disorders such as stroke, autism, Alzheimer’s, schizophrenia, and ADHD.
Catalog no. 2834, June 2006, 400 pp. ISBN: 978-0-8493-2834-3, $169.95 / £108.00 Also available as an eBook
Also available as an eBook
Biology of the NMDA Receptor
Neurosteroid Effects in the Central Nervous System
Edited by
The Role of the GABA-A Receptor
Antonius M. VanDongen
Edited by
Duke University Medical Center, Durham, North Carolina, USA
Sheryl S. Smith
The NMDA receptor, a subclass of the ionotropic glutamate receptor family, plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Describing important aspects of NMDA receptor biology, this text highlights discoveries that have been made over the past decade. It reviews various molecular genetics studies that illustrate the importance of this class of receptors. It also presents a discussion of recent crystallographic X-ray structures of its ligand binding domains.
Catalog no. 44141, October 2008, 350 pp. ISBN: 978-1-4200-4414-0, $169.95 / £108.00 Also available as an eBook
SUNY Health Sciences Center, Brooklyn, New York, USA
A complete overview of the effects of steroid hormones in the brain and new methods for investigating these effects, this book discusses theories on steroid action in the central nervous system and the techniques for receptor localization, quantification, and enzyme regulation. The author explores the use of transgenic/antisense strategies to determine sites and the cellular effects of steroid action in the brain. He examines steroid action on mood, cognition, sensorimotor action, neuroprotection, and plasticity, and describes methods using molecular, electrophysical, and behavioral techniques to link cellular mechanisms of steroid action with behavioral effects.
Catalog no. 2392, October 2003, 408 pp. ISBN: 978-0-8493-2392-8, $179.95 / £115.00 Also available as an eBook
For more information and complete contents, visit www.crcpress.com
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Frontiers in Neuroscience & Neuroengineering Series Methods in Drug Abuse Research
Indwelling Neural Implants
Cellular and Circuit Level Analyses
Strategies for Contending with the In Vivo Environment
Edited by
Edited by
Barry D. Waterhouse
William M. Reichert
MCP-Hahnemann School of Medicine, Philadelphia, Pennsylvania
Duke University, Durham, North Carolina, USA
Assembling information from a wide variety of resources, this book bridges the gap between cellular and molecular studies of drug actions and behavioral approaches to questions in drug abuse research. The book covers procedures, methods, and equipment used in experiments combining multiple technical approaches. It presents critical reviews of the experimental strategies used to dissect the problem of compulsive drug use and addiction at the systems or whole brain level.
This compendium of contributions from noted experts in neuroprosthetics and tissue repair addresses the impact, characterization, and mitigation of the healing of tissues that surround an implant. It examines performance issues of implanted neuroprosthetics, presents both in vitro and in vivo approaches to assessing wound healing response to materials, and describes molecular and materials strategies for intervening in CNS wound repair and enhancing the electrical communication between electrode and surrounding tissue.
Catalog no. 2345, November 2002, 296 pp. ISBN: 978-0-8493-2345-4, $169.95 / £108.00
Catalog no. 9362, December 2007, 296 pp. ISBN: 978-0-8493-9362-4, $169.95 / £108.00
Also available as an eBook
Also available as an eBook
Electrochemical Methods for Neuroscience
Nicotinic Receptors in the Nervous System
Edited by
Adrian C. Michael University of Pittsburgh, Pennsylvania, USA
Edited by
Edward D. Levin Duke University Medical Center, Durham, North Carolina, USA
This volume provides integrated coverage of research on neuronal nicotinic systems relevant to smoking addiction and cognitive dysfunction. Bringing together molecular and neurochemical applications, it provides the key to understanding function and dysfunction of nicotinic systems and their significance for disease, addiction, and the development of novel drug treatments. The book presents readers with the basic mechanistic background for these treatments as well as the functional assessment necessary to determine therapeutic effects.
Catalog no. 2386, August 2001, 312 pp. ISBN: 978-0-8493-2386-7, $169.95 / £108.00 Also available as an eBook
Laura M. Borland Booz Allen Hamilton, Inc., Joppa, Maryland, USA
Providing an updated summary of the current state of the field, this volume lays the scientific foundation for incorporating electrochemical techniques into emerging research. The text outlines the applications and benefits of a wide range of electrochemical techniques. It explores the methodology and protocols behind the acquisition of neurochemical and neurobiological data through continuous amperometry, fast scan cyclic voltammetry, high-speed chronoamperometry, ion-selective microelectrodes, enzyme-based microelectrodes, and in vivo voltammetry with telemetry.
Catalog no. 4075, December 2006, 544 pp. ISBN: 978-0-8493-4075-8, $179.95 / £115.00 Also available as an eBook
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Frontiers in Neuroscience & Neuroengineering Series Motor Cortex in Voluntary Movements A Distributed System for Distributed Functions Edited by
Alexa Riehle INCM - CNRS, Marseille, France
Eilon Vaadia The Hebrew University, Jerusalem, Israel
This book presents developments in motor cortex research that make it possible to read and interpret neural activity and use the data to reconstruct movements. It focuses on how neuronal activity changes during learning, the neuronal representations of voluntary movements, and the mechanism of their generation during learning. Along with detailed coverage of advanced approaches to motor cortex research, the book also includes classical studies of neuronal activity in frontal sensorimotor fields.
Catalog no. 1287, December 2004, 448 pp. ISBN: 978-0-8493-1287-8, $169.95 / £108.00
Modern Neurosurgery Clinical Translation of Neuroscience Advances Edited by
Dennis A. Turner Duke University Medical Center, Durham, North Carolina, USA
Focusing on how increased understanding of brain function affects clinical neuroscience, this volume explores the interface between non-clinical and clinical neuroscience advances by examining the hypotheses that drive this evolution. It reviews the relevant underpinnings of neurosurgical techniques, treatments, and conceptual approaches that are likely to continue to shape clinical neuroscience over the next few years and underscores targeted areas in each field, including high grade gliomas, spinal dysraphism, and endovascular treatment advances.
Catalog no. 1482, June 2004, 344 pp. ISBN: 978-0-8493-1482-7, $169.95 / £108.00 Also available as an eBook
Also available as an eBook
Advances in Vagal Afferent Neurobiology
The Third Histamine Receptor
Edited by Johns Hopkins Asthma Center, Baltimore, Maryland, USA
Selective Ligands as Potential Therapeutic Agents in CNS Disorders
Daniel Weinreich
Edited by
Bradley J. Undem
University of Maryland, Baltimore, USA
Taking a comprehensive approach in which all aspects of the vagal afferent system are considered, this extensive text reviews the development, neurochemistry, anatomy, biophysics, pharmacology, and physiology of the vagal afferent nerves. The authors present experimental techniques used to investigate the development, morphology, electrophysiology and reflex function of the vagal afferent nerves, and include state-of-the-art reviews of vagal afferent neurobiology by some of the world's leading experts in these fields.
Catalog no. 2131, June 2005, 544 pp. ISBN: 978-0-8493-2131-3, $189.95 / £120.00 Also available as an eBook
Divya Vohora Hamdard University, New Delhi, India
Since their discovery, the potential of histamine H3 receptor ligands in various CNS disorders has received much attention. This resource presents recent advances with an emphasis on pharmacology. It covers identification and localization of receptors and the development of novel ligands incorporating preclinical and clinical studies indicating earliest possible stages of development. The book provides an overview of histamine as a neurotransmitter and discusses receptor pharmacology, signal transduction, selective ligands, and therapeutic potential.
Catalog no. 53922, November 2008, 400 pp. ISBN: 978-1-4200-5392-0, $179.95 / £115.00 Also available as an eBook
For more information and complete contents, visit www.crcpress.com
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Clinical Neuroscience New! Bestseller!
Atlas of Functional Neuroanatomy
ChemotherapyInduced Neuropathic Pain
Second Edition
Edited by
Walter Hendelman, M.D. University of Ottawa, Ontario, Canada
“… an excellent tool for introducing the basic concepts of neuroanatomy …” —Estrada J. Bernard Jr., M.D., Journal of Neurosurgery
A visual and textual guide, the Atlas of Functional Neuroanatomy, Second Edition clearly presents the human central nervous system. Completely revised and now containing color illustrations, the atlas imparts information in a format that fosters a thorough understanding of complex neuroanatomy. The illustrations and text accompanying each illustration supply the appropriate neuroanatomical information to gain a full understanding of the human CNS from a functional perspective. Clinical aspects add to the value of the atlas.
Features: • An organized orientation to the CNS with new and revised material, and the lucid presentation of sensory and motor functional systems • A systematic description of the cerebral blood supply and a detailed histological study of brainstem and spinal cord neuroanatomy • A fresh approach to the limbic system that provides a clearer understanding of its structures and functions • Color illustrations throughout the text, an annotated bibliography, and a glossary of terms • An interactive CD-ROM with text, color illustrations, 3D visualization, and animation The illustrations, text, selection of the content, and the accompanying CD-ROM are unique features that differentiate this atlas from others and will make it one of the most used references for scientists and students in a diverse array of fields.
Catalog no. 3084, October 2005, 296 pp. Soft Cover ISBN: 978-0-8493-3084-1, $67.95 / £43.99 Also available as an eBook
Robert B. Raffa, Richard Langford, Joseph V. Pergolizzi, Jr., Frank Porreca, and Ronald J. Tallarida There have been tremendous recent advances in the pharmacotherapy, dose regimens, and combinations used to treat cancer and for the treatment or prevention of the spread of disease. As a direct result of these advances, there are an increasing number of cancer survivors, although research dealing with chemotherapy-induced pain is still in its early years. Written for pain management specialists, oncologists, pharmacologists, students, and primary care practitioners, Chemotherapy-Induced Neuropathic Pain provides insight into the critical area of pain management among cancer patients. It reviews the basic and clinical research into the normal physiology of pain transmission pathways, neuropathic pain pathology, the chemotherapeutic drug mechanisms of action and adverse effects, chemotherapy-induced neuropathy, and drug discovery efforts for treatment. The contributors comprise an impressive list of clinical and basic science experts in the fields of pain mechanisms and pain management. Included are clinical directors of pain clinics and clinical research facilities, directors of large academic pain research laboratories, analgesic drug developers, and presidents of the International Association for the Study of Pain (IASP), Association of Chronic Pain Patients (ACPP), and the British Pain Society (BPS). The book provides readers with an exceptional opportunity to acquire a fundamental understanding of the basic concepts related to this topic.
Contents: Chemotherapy-Induced Neuropathic Pain: Clinical Features. Assessment and Grading of Cancer Chemotherapy-Induced Neuropathic Pain. Chemotherapy-Induced Peripheral Neuropathy: Review of Clinical Studies. Orofacial Neuropathy and Pain in Cancer Patients. Cancer ChemotherapyInduced Neuropathic Pain: The Underlying Peripheral Neuropathy. Bedside to Bench: Research on Chemotherapy-Induced Neuropathic Pain. In Vivo Models and Assessment of Pharmacotherapeutics for Chemotherapy-Induced Neuropathic Pain. Drug Treatment for Chemotherapy-Induced Neuropathic Pain: Amitriptyline as an Example. Experimental Design and Analysis of Drug Combinations Applicable to Chemotherapy-Induced Neuropathic Pain. Central Neuromodulation for ChemotherapyInduced Neuropathic Pain. Nerve Decompression for Chemotherapy-Induced Neuropathic Pain.
Catalog no. K12881, July 2012, 233 pp. ISBN: 978-1-4398-6218-6, $149.95 / £95.00 Also available as an eBook
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Clinical Neuroscience Epilepsy The Intersection of Neurosciences, Biology, Mathematics, Engineering, and Physics Edited by
Ivan Osorio, Hitten P. Zaveri, Mark G. Frei, and Susan Arthurs One of the most prevalent neurological disorders, epilepsy affects approximately one percent of the world's population. Epilepsy: The Intersection of Neurosciences, Biology, Mathematics, Engineering, and Physics seamlessly brings together these fields along with the computational sciences and clinical epileptology to present to readers a practically useful knowledge base. Laying out the foundations of signal analysis, data conditioning, linear and non-linear analysis, introduction to dynamical systems and fundamental anatomical and neurophysiological concepts, this book: • Introduces non-physicians to language and concepts necessary to establish a meaningful dialog with epileptologists • Introduces physicians to dynamical theory and signal processing • Combines knowledge from fields devoted to the investigation of aperiodic paroxysmal relaxation phenomena to lay the proper scientific foundations for epileptology and foster much needed therapeutic advances efficiently • Reviews spatiotemporal behavior of seizures, mechanisms of epileptogenesis and ictogenesis, and seizure control and ancillary technology • Highlights nocturnal frontal lobe epilepsy as a potentially fruitful paradigm for advancing seizure prediction. Of all neurological disorders, epilepsy demands of investigators the broadest and deepest knowledge of dynamical, control, and system theories, knowledge that cannot be amassed without possessing a certain level of sophistication in relevant areas of neurosciences, physics, mathematics, and engineering. Narrowing the inescapable cultural chasm that commonly fragments multidisciplinary efforts, this book captures and enriches the burgeoning interdisciplinary synergism in the nascent field of dynamical epileptology.
Catalog no. K11766, May 2011, 546 pp. ISBN: 978-1-4398-3885-3, $189.95 / £121.00 Also available as an eBook
Pediatric Epilepsy Case Studies From Infancy and Childhood through Adolescence Edited by
Kevin Chapman and Jong M. Rho Barrow Neurological Institute, Phoenix, Arizona, USA
The amount of information currently available on pediatric epilepsy, as with all burgeoning fields, can seem overwhelming. Pediatric Epilepsy Case Studies: From Infancy and Childhood through Adolescence reviews the recent flood of new information on the pathophysiology, genetics, and treatment of the various pediatric epilepsy syndromes and distills it into an easy-to-use guide. Edited by respected and well-known leaders in the field, the book provides brief but thorough descriptions of the different syndromes commonly encountered in clinical practice across the pediatric age range. Grasping the complexity and nuances associated with various epileptic syndromes can be daunting, so the book begins with an introduction to the fundamentals of epilepsy. Subsequent sections include succinct case presentations and clinically relevant discussions of the more common epilepsy syndromes affecting each age group. The resource section provides an authoritative guide to relevant findings scattered in the literature. Research in the field of epilepsy will continue at a rapid pace, with the ultimate hope of curing many intractable epilepsy syndromes. Organized chronologically, from neonate through adolescence, this book is the culmination of a group effort involving leading physicians and researchers whose contributions constitute a concise and practical reference for health professionals in training.
Selected Contents (Abridged) The Basics. A Pediatric Epilepsy Primer. Developmental Pharmacokinetics: Principles and Practice. Dietary Therapies for Epilepsy... The Neonate Benign Familial Neonatal Seizures. Hypoxic-Ischemic Encephalopathy (Neonatal Seizures)... The Infant Febrile Seizures. Generalized Epilepsy with Febrile Seizures Plus (GEFS+). Benign Myoclonic Epilepsy of Infancy. Severe Myoclonic Epilepsy in Infancy. Infantile Spasms. Gelastic Seizures. Tuberous Sclerosis Complex... The Child. Benign Epilepsy of Childhood with Central-Temporal Spikes. Childhood Absence Epilepsy... The Adolescent. Juvenile Myoclonic Epilepsy. Epilepsy in Adolescent Females. Unverricht–Lundborg Disease. Post-Traumatic Seizures and Epilepsy... Index.
Catalog no. 83422, September 2008, 296 pp. ISBN: 978-1-4200-8342-2, $89.95 / £57.99
For more information and complete contents, visit www.crcpress.com
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Clinical Neuroscience New!
Bestseller!
Multiple Sclerosis Rehabilitation
Traumatic Brain Injury
From Impairment to Participation Edited by
Rehabilitation, Treatment, and Case Management, Third Edition
Marcia Finlayson
Edited by
University of Illinois at Chicago, USA
Mark J. Ashley
This comprehensive resource guides health and rehabilitation practitioners as they engage in the rehabilitation process with people with multiple sclerosis (MS). The text provides a broad-based perspective on the disease and examines how it influences everyday life. It also examines the strategies that can be employed by rehabilitation practitioners to enable people with MS to fully engage in life. The first section offers an overview of MS basics, and the next two describe MS rehabilitation to manage impairments and enhance activity and participation. The final section discusses contextual factors that may influence MS rehabilitation efforts.
" ...will provide a valuable resource to nonspecialists. … excellent material."
Catalog no. K11417, August 2012, 603 pp. ISBN: 978-1-4398-2884-7, $149.95 / £95.00 Also available as an eBook
The Neuroscience of Handwriting Applications for Forensic Document Examination Michael P. Caligiuri University of California, San Diego, La Jolla, USA
Linton A. Mohammed Rile, Hicks, & Mohammed, San Bruno, California, USA
Bridging the gap between theory and practice, this volume examines the essential neuroscientific principles underlying normal and pathological hand motor control and handwriting. The book discusses fundamental principles in the neuroanatomy and neurochemistry of hand motor control and their application to research in handwriting. It examines the epidemiology, pathophysiology, and motor characteristics of neurogenerative diseases and their effects on handwriting and describes the impact of psychotropic medications, substance abuse, and aging. The authors present new findings on the kinematic analyses of genuine, disguised, and forged signatures and include laboratory research on authentic and forged signatures.
Centre for Neuro Skills of California, Bakersfield, USA
—Journal of the Royal Society of Medicine
Since the bestselling second edition was published almost a decade ago, the field of brain injury treatment has undergone tremendous change, largely impacting access to treatment. With updated and expanded clinical coverage, Traumatic Brain Injury: Rehabilitation, Treatment, and Case Management, Third Edition delineates a broad spectrum of advanced theoretical clinical constructs and detailed diagnostic and treatment interventions for traumatic brain injury. This text is a clinical guide to rehabilitative treatment of persons with traumatic brain injury following the acute phase of treatment. It provides a concise source of information about the scientific and therapeutic realms involved in the rehabilitation of a person with traumatic brain injury, specifically as they relate to persistent deficits. The book also details long-term consequences of brain injury and effective approaches to vocational rehabilitation and case management.
Topics discussed include: • Metabolic and bioenergetic factors in brain injury • Neuroendocrine dysfunction following brain injury • Blast injury • Ethical issues in treatment of brain injury • Neuropharmacological and neuropsychological interventions following brain injury • Interventions for the minimally conscious patient • Dietary and exercise considerations after brain injury This volume is a complete source of pharmacological, anatomical, and physiological information for basic therapeutic rationales.
Catalog no. 71947, May 2010, 1079 pp. ISBN: 978-1-4200-7194-8, $169.95 / £108.00 Also available as an eBook
Catalog no. K13270, February 2012, 267 pp. ISBN: 978-1-4398-7140-9, $139.95 / £89.00 Also available as an eBook
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Clinical Neuroscience Pocket Handbook of Nonhuman Primate Clinical Medicine
The Integrated Nervous System A Systematic Diagnostic Approach Walter J. Hendelman
Edited by
University of Ottawa, Ontario, Canada
Dr. Angela Courtney
Peter Humphreys
University of California, Davis, USA
Children's Hospital of Eastern Ontario, Canada
An easy-to-understand pocket manual, this indispensible reference compiles key and important clinical medical information unique to the rhesus macaque and the cynomolgus macaque. The chapter authors denote specific treatments for other nonhuman primate species where applicable. Practical and userfriendly, this book mirrors the knowledge gained by completing a residency in clinical primate medicine. It provides formulary and drug dosages, special precautions, and important notations; discusses diseases and clinical problems; outlines treatment based on current medicine; and explains common procedures with color illustrations.
Christopher Skinner
Catalog no. K13021, October 2012, 232 pp. Soft Cover ISBN: 978-1-4398-6728-0, $99.95 / £63.99 Also available as an eBook
Epileptic Seizures and the EEG Measurement, Models, Detection and Prediction Andrea Varsavsky and Iven Mareels The University of Melbourne, Victoria, Australia
Mark Cook St. Vincent's Hospital and the University of Melbourne, Victoria, Australia
A study of epilepsy from an engineering perspective, this volume begins by summarizing the physiology behind the measurement, analysis, and modeling of the epileptic brain. It introduces the EEG and explains the type of brain activity likely to register in EEG measurements. The authors focus on the problem of seizure detection, survey the physiologically based dynamic models of brain activity, and address the fundamental question of whether seizures can be predicted.
Ottawa Hospital, Ontario, Canada
“ … an appropriate supplementary text for any clinically-based neuroscience course or an excellent reference book. The DVD contains all the illustrations in the text, animations of reflexes and neuronal pathways, additional case studies, worksheets for the clinical cases, and information on neural imaging. Suggested readings are in the form of journal articles listed at the end of each chapter. Also, an annotated bibliography, organized by topic and with a synopsis of each entry, is found at the back of the book. A helpful glossary is also included.” —The Internet Journal of Allied Health Science and Practice
To demonstrate the connection between academic neuroanatomy and the practice of clinical neurology, The Integrated Nervous System: A Systematic Diagnostic Approach presents carefully chosen clinical cases that illustrate how the nervous system is constructed and how it functions under normal circumstances. It contains a fail-safe localization/etiology checklist and details autoimmune, neoplastic, degenerative, and genetic disorders. The book instructs on how to differentiate between various causes of seizures, stroke, and Parkinsonism, and provides complete case summaries, treatment, management, and outcomes to clarify the material. Offering the foundation needed to encounter neurological diseases, this reference teaches students and residents how to integrate a patient’s clinical history and examination with neuroanatomy. In addition to color illustrations throughout, the book is supplemented by an invaluable DVD and access to a stateof-the-art website with additional materials that are updated periodically. User-friendly worksheets and flash animation of various pathways, reflexes, and circuits are also included.
Catalog no. 45970, September 2009, 352 pp. ISBN: 978-1-4200-4597-0, $87.95 / £55.99 Also available as an eBook
Catalog no. K10604, December 2010, 370 pp. ISBN: 978-1-4398-1200-6, $145.95 / £93.00 Also available as an eBook
For more information and complete contents, visit www.crcpress.com
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Clinical Neuroscience Diet, Brain, Behavior
Concussive Brain Trauma
Practical Implications
Neurobehavioral Impairment & Maladaptation, Second Edition
Edited by
Robin B. Kanarek
Rolland S. Parker
Tufts University, Medford, Massachusetts, USA
New York University School of Medicine, USA
Harris R. Lieberman
This second edition of a bestseller provides comprehensive coverage of neurobehavioral disorders in children and adults following impact and acceleration accidents. Drawing on his training, education, and experience in human physiology, neuroanatomy, and endocrinology, the author gives readers a solid foundation for understanding, diagnosing, and treating concussive brain trauma. The book discusses personality and subjective complaints and symptoms and includes six new chapters and new material on dysregulation of the internal environment.
Catalog no. 8039, September 2011, 879 pp. ISBN: 978-0-8493-8039-6, $159.95 / £99.00
USARIEM, Natick, Massachusetts, USA
Both the scientific community and the general population have expressed a heightened interest in the effect of nutrients on behavior. Topics discussed in this volume include mental energy and fatigue, obesity and its effect on behavior, weight loss methods, and the effects of dietary supplements on brain functioning and behavior. The book also examines the reward deficiency hypothesis, proper fluid intake, the effects of eating breakfast on performance, and diet and pain sensitivity.
Also available as an eBook
Catalog no. K11143, October 2011, 335 pp. ISBN: 978-1-4398-2156-5, $149.95 / £95.00
Bestseller!
Maldynia
Understanding Autism
Multidisciplinary Perspectives on the Illness of Chronic Pain
Also available as an eBook
From Basic Neuroscience to Treatment
Edited by
James Giordano
Edited by
Steven O. Moldin University of Southern California, Washington, D.C., USA
John L. R. Rubenstein University of California, San Francisco, USA
Integrating basic and clinical neuroscience perspectives, this work presents a comprehensive outlook on current autism research. The book covers a broad range of fields, including epidemiology, genetics, and clinical neuroscience and neural systems. An underlying theme focuses on future genomic research and the text also explores social, economic, and advocacy issues. The research contained herein will stimulate new directions for advancement and the development of new drug treatment.
Catalog no. 2732, April 2006, 552 pp. ISBN: 978-0-8493-2732-2, $199.95 / £127.00 Also available as an eBook
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Center for Neurotechnology Studies, Potomac Institute for Policy Studies, Arlington, Virginia, USA and Human Science Center, Ludwig-Maximilians University, Munich Germany
An in-depth examination of chronic pain, this book explores pain as a bio-cultural phenomenon that necessitates reexamination of medical philosophy, ethics, education, and practice. It provides a historical account of pain and then frames it with contemporary neurobiological perspectives. The book illustrates how what we know about pain could influence medical education and practice and demonstrates how knowledge of the history and present considerations of pain might help to construct meaningful, patient-centered medicine.
Catalog no. K11642, December 2010, 280 pp. ISBN: 978-1-4398-3630-9, $159.95 / £99.00 Also available as an eBook
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Clinical Neuroscience Autism Neuroanatomical Basis of Clinical Neurology
Oxidative Stress, Inflammation, and Immune Abnormalities
Edited by
Abha Chauhan, Ved Chauhan, and W. Ted Brown
Orhan Arslan University of South Florida, Tampa, USA
Superbly illustrated, this volume bridges the gap between the disciplines of neuroanatomy and neurology, aiding the understanding of neurologic disorders by investigating their anatomic basis. The extensive coverage of the peripheral and central nervous systems in the context of neurological disorders and conditions sets it apart from other neuroanatomy texts. The author has skillfully integrated text and diagrams, highlighting and clarifying the numerous functionally important pathways in the central and peripheral nervous systems.
Catalog no. PA578X, August 2001, 432 pp. ISBN: 978-1-85070-578-9, $77.95 / £49.99 Also available as an eBook
New York State Institute for Basic Research in Developmental Disabilities, Staten Island, USA
The CDC issued an alert indicating that autism may impact one out of every 150 children. While the syndrome is still officially labeled as idiopathic, research shows the cause of autism may possess genetic, environmental, and possibly immunological factors and that it has at least a correlation to oxidative stress. This book collects work from researchers who report on evidence indicating links between autism and a number of oxidative stress-related abnormalities. The text also reports on potential avenues for new therapeutic intervention strategies.
Catalog no. 68814, October 2009, 452 pp. ISBN: 978-1-4200-6881-8, $174.95 / £112.00 Also available as an eBook
Forthcoming!
Epilepsy
Parkinson's Disease
Mechanisms, Models, and Translational Perspectives
Second Edition Edited by
Ronald F. Pfeiffer University of Tennessee Health Science Center, Memphis, USA
Zbigniew K. Wszolek
Edited by
Jong M. Rho Alberta Children's Hospital, Calgary, Canada
Raman Sankar
Mayo Clinic, Jacksonville, Florida, USA
University of California School of Medicine, Los Angeles, USA
Manuchair Ebadi
Carl E. Stafstrom
University of North Dakota, Grand Forks, USA
In recent years, considerable advances have been made in our knowledge and understanding of Parkinson's disease (PD). In particular, there has been an explosion of information regarding genetic contributions to the etiology of PD and an increased awareness of the incidence and importance of the nonmotor features of the disease. Theories regarding the pathogenesis and pathophysiology of PD have also been refined, and new treatment modalities and advances have been implemented. Reflecting these changes, this second edition features new chapters devoted to these areas and new treatment modalities.
Catalog no. K10361, October 2012, c. 1336 pp. ISBN: 978-1-4398-0714-9, $249.95 / £159.00 Also available as an eBook
University of Wisconsin, Madison, USA
Written for researchers and clinicians in neurology and neuroscience, this text offers a bridge across the socalled translational divide to cover innovative treatment strategies that, while based on scientific principles, have yet to be tested rigorously in clinical settings. The text features the contributions of leading researchers in adult and pediatric epilepsy who cover a range of topics including gene therapy, metabolic regulation, and neuroprotective strategies. It highlights therapies with the greatest potential and identifies challenges common to researchers.
Catalog no. 8559X, June 2010, 684 pp. ISBN: 978-1-4200-8559-4, $199.95 / £127.00 Also available as an eBook
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Clinical Neuroscience Automated EEGBased Diagnosis of Neurological Disorders Inventing the Future of Neurology
Coffee, Tea, Chocolate, and the Brain
Hojjat Adeli
Edited by
The Ohio State University, Columbus, USA
Astrid Nehlig
Samanwoy Ghosh-Dastidar Based on the authors' groundbreaking research, this book presents a novel approach for automated EEGbased diagnosis of neurological disorders such as epilepsy. The method is based on the adroit integration of three computing and problem-solving paradigms: neural networks, wavelets, and chaos theory. The text introduces each of these computing paradigms along with a number of sophisticated mathematical algorithms. It concludes with applications of the method to epilepsy and to Alzheimer's disease.
With contributions from world experts in the field, this volume analyzes current research findings on caffeine compounds and their interaction with the brain and central nervous system. The book discusses the effects of coffee, tea, and chocolate on memory, cognitive performance, Parkinson's disease, stroke, oxidative stress, headache and sleep disorders, addiction dependence, and more. It also explores the relationships between caffeine and seizures, blood flow, alertness, and cravings. This reference is an essential resource for all students and researchers of nutrition, psychology, neuroscience, pharmacology, and other health-related sciences.
Catalog no. K10784, February 2010, 423 pp. ISBN: 978-1-4398-1531-1, $169.95 / £108.00
Catalog no. TF1650, April 2004, 248 pp. ISBN: 978-0-415-30691-1, $135.95 / £87.00
Inserm, Strasbourg, France
Ardmore, Pennsylvania, USA
Also available as an eBook
Manual of Stroke Models in Rats Edited by Palatin Technologies, Cranbury, New Jersey, USA
While new insights into the mechanisms and the treatment of stroke have been obtained from animal experiments over the past several years, this is the first book in more than two decades to compile research in this essential area. Cutting-edge researchers offer detailed explanations of the methods and techniques for accomplishing different stroke models in rats. As of now, no specific neuroprotective treatment for ischemic stroke is available. This book provides a starting point for those researchers employing stroke models to develop new drugs to counteract this problem.
Catalog no. 9578, August 2008, 352 pp. Soft Cover ISBN: 978-0-8493-9578-9, $115.95 / £73.99
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Augmenting Cognition Idan Segev The Hebrew University, Jerusalem, Israel
Henry Markram
Yanlin Wang-Fischer
Also available as an eBook
Also available as an eBook
Swiss Federal Institute of Technology, Lausanne, Switzerland
Augmenting cognition is a rapidly emerging field in neuroscience, concerned with the translation of what is known about cognitive function and dysfunction to approaches for enhancing and rehabilitating the brain. Modern medicine has few options to treat those with cognitive deficiencies, and as we learn more about the biology of these conditions, we consider the design of a new class of therapies to restore and augment cognition. This book describes a number of the foundational areas of cognitive enhancement, with chapters devoted to the use of stem cells, savants, post-traumatic stress disorder, deep-brain stimulation, drugs, virtual reality, the role of sleep, and the brain-computer interface.
Catalog no. N10260, November 2011, 250 pp. ISBN: 978-1-4398-3993-5, $89.95 / £57.99
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Neuroscience Forthcoming!
New!
Neuroadaptive Systems
Neuropeptides in Neuroprotection and Neuroregeneration
Theory and Applications Edited by
Magdalena Fafrowicz, Tadeusz Marek, Waldemar Karwowski, and Dylan Schmorrow Neuroadaptive Systems: Theory and Applications is one of the first texts to address this emerging field and to present the state-of-the-art developments in current research. The scope of coverage includes neuroscience and human factors as well as brain activity measurement. Topics include operator functional state (OFS) and neuroadaptive systems, psychological constructs versus neuronal mechanisms, object recognition versus object-directed grasping, mental fatigue, sleeplessness, neural mechanisms of control, and attentional network- and error-related negativity associated with sleep deprivation.
Edited by
Fred Nyberg University of Uppsala, Sweden
This volume discusses neuropeptides and their role in neurodegeneration and neuroprotection. It describes important features of the endogenous neuropeptide systems regarding their formation, receptor signaling, and inactivation. The contributors examine topics of enormous interest in the field—including the design and development of peptide-like drugs, peptidomimetics, mechanisms of peptide transport over biological barriers, oxidative stress, and cognitive enhancement. It also clarifies the basic molecular mechanisms of the neuronal and nitropeptidergic processes that are important in cognition.
Contents:
Catalog no. K11501, June 2012, 319 pp. ISBN: 978-1-4398-3062-8, $149.95 / £95.00
Theoretical Issues
Also available as an eBook
Augmented Cognition Neuroscience and Human Factors Psychological Constructs vs. Neuronal Mechanisms Different Perspectives for Advanced Technologies
New!
Research
Neurotechnology
Attention - Individual Differences - Genetic Perspective
Premises, Potential, and Problems
Object Recognition vs. Object-Directed Grasping Neural Signatures Of Learning to Direct Training Mental Fatigue, Sleeplessness and Neural Mechanisms of Control EEG Cognitive Assessment Using Eye Fixations Error Related Negativity and Sleep Deprivation Attentional Network and Sleep Deprivation Motor Activity, Cortical Potentials and Muscular Performance
Edited by
James Giordano Center for Neurotechnology Studies, Potomac Institute for Policy Studies, Arlington, Virginia, USA and Human Science Center, Ludwig-Maximilians University, Munich, Germany
A Neuro-Fuzzy Approach to Modeling of Human Motor Control
New technologies that allow us to investigate mechanisms and functions of the brain have shown considerable promise in treating brain disease and injury. These emerging technologies also provide a means to assess and manipulate human consciousness, cognitions, emotions, and behaviors, bringing with them the potential to transform society. This volume explores the technical, moral, legal, and sociopolitical issues that arise in and from today’s applications of neuroscience and technology and discusses their implications for the future. Topics include neurotechnology in education, neuroimaging and tissue implantation technology neuroprostheses, cyborg technology, and more.
Catalog no. K12687, October 2012, c. 410 pp. ISBN: 978-1-4398-5745-8, $129.95 / £82.00
Catalog no. K11241, April 2012, 354 pp. ISBN: 978-1-4398-2586-0, $119.95 / £76.99
Also available as an eBook
Also available as an eBook
Applications Driving and Safety - Neuronal Perspective Advanced Tactical Aircraft Simulator - Quality Training Effectiveness Assessment (Atas-Qte) User-In-The-Loop Adaptive System Design Interactive Neurotechnology Platform Robots and 3d Shapes Perception
For more information and complete contents, visit www.crcpress.com
23
Neuroscience New!
Microfabricated Cortical Neuroprostheses
Neurons and the DHA Principle Raymond C. Valentine University of California at Davis, Professor Emeritus, USA and Visiting Scholar, University of California, Santa Barbara, USA
David L. Valentine University of California, Santa Barbara, USA
Recent discoveries have highlighted the role of omega-3 fatty acid DHA in brain health and degeneration as well as the molecular biology of this fatty acid in neurons. This research has led to a new theory of neurodegeneration. This book provides in-depth coverage of the molecular biology of the omega-3 fatty acid DHA in neurons. Using examples from the world of animal cells, the book illustrates the role of DHA in the brain. It examines DHA benefits and risks and discusses the link between DHA and the effects of aging.
Catalog no. K13471, November 2012, c. 272 pp. ISBN: 978-1-4398-7486-8, $159.95 / £95.00
Edited by
André Mercanzini and Philippe Renaud Faculty of Engineering, Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland
Despite their demonstrated effectiveness, the longterm use of microscale neuroprosthetic devices is frequently compromised by the postimplantation tissue reaction that can form around the device. This book studies ways to improve the tissue reaction to implanted neuroprosthesis by use of a controlled drug release mechanism, quantified by novel measurement techniques. The author, a holder of two U.S. patents on microassembly, also examines ways to improve neural stimulation and recording capability.
Catalog no. N10256, January 2011, 250 pp. ISBN: 978-1-4398-3754-2, $89.95 / £57.99
Also available as an eBook
Time Series Modeling of Neuroscience Data
TRP Channels Edited by
Tohru Ozaki
Michael X. Zhu
Institute of Statistical Mathematics, Tokyo, Japan
The University of Texas Health Science Center at Houston, USA
Due to recent advances in methodology that offer significant improvements over conventional methods, there is increasing interest in the use of time series models for the study of neuroscience data such as EEG, MEG, fMRI, and NIRS. This book presents an overview of time series models for the study of neuroscience data. Accessible to applied statisticians as well as quantitatively trained neuroscientists, the book is supported by many real examples to illustrate the methods and provides useful instructions for computational problems, enabling readers to develop their own computational toolbox to apply the methods to real data.
Providing detailed methods for the study of transient receptor potential (TRP) channels and their role in a wide variety of cellular functions, this book includes expression and functional studies of TRP channels in heterologous systems as well as structural and functional studies of TRP channels. The author also explores various methods for detailed analysis of biophysical properties of TRP channels. In addition, the text covers high-throughput screening assays for TRP channels and offers novel and effective approaches to study endogenous TRP channel function in native systems.
Catalog no. C4602, January 2012, 574 pp. ISBN: 978-1-4200-9460-2, $99.95 / £63.99
Catalog no. K10983, April 2011, 499 pp. ISBN: 978-1-4398-1860-2, $149.95 / £95.00 Also available as an eBook
Also available as an eBook
24
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Neuroscience
The Female Brain Second Edition
Atlas of Human Central Nervous System Development
Cynthia L. Darlington
Five-Volume Set
University of Otago, Dunedin, New Zealand
Shirley A. Bayer and Joseph Altman
The first edition of this bestseller laid the groundwork for understanding the female brain, examining the evidence of structural and functional differences between the brains of males and females. Addressing a wealth of current research, the second edition continues in this vein, leading readers through the basic principles of anatomy and physiology and on to the complex behavioral functions which constitute the workings of the normal and abnormal female brain. Filled with rigorous scientific analysis in an easily accessible format, the book delineates gender-based differences between brains and explains why they should be considered when designing research and clinical studies.
Indianapolis, Indiana, USA
Catalog no. 77449, April 2009, 266 pp. ISBN: 978-1-4200-7744-5, $139.95 / £89.00
Catalog no. 68008, July 2007 ISBN: 978-1-4200-6800-9, $850.00 / £541.00
Also available as an eBook
Micronutrients and Brain Health Edited by
Lester Packer, Helmut Sies, Manfred Eggersdorfer, and Enrique Cadenas Under the direction of leading experts in oxidative stress, this book addresses cutting-edge areas of research regarding micronutrients and the brain. It discusses age-related metabolic pathways, mitochondrial nutrients, and neurodegeneration. Additional chapters cover flavonoids, cell signaling, and neuronal functions, as well as the role of choline, amino acids, metals, and other micronutrients in brain health. The text places a particular emphasis on lipoic acid, which is shown to be a therapeutic agent.
Catalog no. 73516, October 2009, 460 pp. ISBN: 978-1-4200-7351-5, $184.95 / £118.00 Also available as an eBook
This award-winning series provides a complete record of the development of the human central nervous system from spinal cord gestation through the third trimester. The contents are organized by coronal, sagittal, and horizontal planes of sectioning, ensuring pictorial representation of nearly every structure in the developing brain. Each volume provides two-page spreads containing high-resolution black and white images opposite ghost images with unabbreviated labels that clearly identify each structure. The final volume summarizes major events of CNS development and offers a theoretical account of the morphogenetic processes involved.
The Spinal Cord from Gestational Week 4 to the 4th Postnatal Month Shirley A. Bayer and Joseph Altman Indianapolis, Indiana, USA
This first volume in the Atlas of Human Central Nervous System Development series sets the stage with complete coverage of the spinal cord from gestational week 4 to the 4th postnatal month. 3D color images provide a holistic view of the structural changes during spinal cord morphogenesis. Providing quantitative summaries of several ontogenetic trends, it features all the stages of spinal cord development, offers fresh insights into the steps involved in the morphogenesis of the mature spinal cord, and shows the human spinal cord at its most primitive stage—consisting mainly of neuroepithelial stem cells.
Catalog no. 1420, May 2002, 256 pp. ISBN: 978-0-8493-1420-9, $249.95 / £159.00 Also available as an eBook
For more information and complete contents, visit www.crcpress.com
25
Neuroscience The Human Brain during the Third Trimester
The Human Brain During the Late First Trimester
Shirley A. Bayer and Joseph Altman Indianapolis, Indiana, USA
Since the brain in the third trimester is nearing maturity, this atlas can serve as a comprehensive guide to structures in the adult brain. High magnification views of different areas of the cerebral cortex and cerebellar cortex show the degree of maturation of these large structures in the third trimester brain. This atlas reveals the maturation of the brain's settled and enduring neural populations. It also uncovers information about immature features of the perinatal brain that have never before been identified.
Catalog no. 1421, December 2003, 392 pp. ISBN: 978-0-8493-1421-6, $229.95 / £146.00 Also available as an eBook
Shirley A. Bayer and Joseph Altman Indianapolis, Indiana, USA
The fourth volume in the Atlas of Human Central Nervous System Development series explores features of the perinatal brain, examining brain development during the late first trimester (GW11-GW7.5). The major theme of this volume is the identification of stretches and patches (mosaics) of the NEP matrix along the hypertrophied telencephalic, diencephalic, mesencephalic, and rhombencephalic superventricles. The book also identifies many putative migratory paths of young nerons on their way to their settling sites.
Catalog no. 1423, April 2006, 592 pp. ISBN: 978-0-8493-1423-0, $219.95 / £140.00 Also available as an eBook
The Human Brain during the Second Trimester
The Human Brain during the Early First Trimester
Shirley A. Bayer and Joseph Altman Indianapolis, Indiana, USA
“ … an excellent exposition of the fetal human brain development which contains valuable information not readily accessible elsewhere ... will be a worthwhile addition to the libraries of neurosciences whose pursuits require ready access to an authoritative atlas on development of the human brain in the second trimester. This user-friendly atlas will also be useful to residents, and even graduate students needing to learn about the human brain development." —Journal of Chemical Neuroanatomy
Catalog no. 1422, May 2005, 384 pp. ISBN: 978-0-8493-1422-3, $209.95 / £134.00 Also available as an eBook
Shirley A. Bayer and Joseph Altman Indianapolis, Indiana, USA
This is the fifth and concluding volume in the Atlas of Human Central Nervous System Development. With high-resolution black and white photos as well as ghost image photos with unabbreviated labels, it surveys structural processes that occur during development. Experimental H-thymidine radiography is used to identify previously unknown structures. The book is divided into two main sections: sagittal and frontal plane specimens. This volume also contains a summary analysis of some of the morphogenetic processes involved in human brain development.
Catalog no. 1424, July 2007, 536 pp. ISBN: 978-0-8493-1424-7, $199.95 / £127.00 Also available as an eBook
26
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Lab Animal Science
Laboratory Animal Pocket Reference Series Thirteen-Volume Set
Buy the Set & Save!
Edited by
Mark A. Suckow
Catalog no. 2560, ISBN: 978-0-8493-2560-1
University of Notre Dame, Indiana, USA
Amply illustrated with figures and tables, each book in this 13-volume $649.95 / £414.00 series is a single-source reference that allows for the humane, healthy, and efficient handling of laboratory animals. These reader-friendly volumes detail basic information and common procedures for individuals performing research with laboratory animals, including duties of animal facility management, animal husbandry, regulatory compliance, and technical procedures. They also discuss possible sources and suppliers of animals, feed, sanitation supplies, cages, and research and veterinary supplies. The newest additions to the series (The Laboratory Rabbit, The Laboratory Xenopus sp., The Laboratory Swine, and The Laboratory Zebrafish) are now in color.
Also available as stand-alone references New!
The Laboratory Nonhuman Primate
The Laboratory Mouse
Catalog no. 2562, September 2001, 288 pp. Soft Cover, ISBN: 978-0-8493-2562-5, $59.95 / £38.99
Second Edition Catalog no. K12511, September 2012, 256 pp. Soft Cover, ISBN: 978-1-4398-5421-1, $59.95 / £38.99
Also available as an eBook
Forthcoming!
Catalog no. 1035, December 1999, 152 pp. Soft Cover, ISBN: 978-0-8493-1035-5, $55.95 / £35.99
The Laboratory Rat
The Laboratory Swine
Second Edition
Also available as an eBook
Catalog no. K11462, December 2012, c. 368 pp. Soft Cover, ISBN: 978-1-4398-2986-8, $59.95 / £38.99
The Laboratory Small Ruminant
Also available as an eBook
The Laboratory Ferret Catalog no. K12861, March 2012, 123 pp. Soft Cover, ISBN: 978-1-4398-6181-3, $59.95 / £38.99 Also available as an eBook
The Laboratory Zebrafish Catalog no. K10378, December 2010, 274 pp. Soft Cover, ISBN: 978-1-4398-0743-9, $59.95 / £38.99
Catalog no. 2568, March 1999, 176 pp. Soft Cover, ISBN: 978-0-8493-2568-7, $59.95 / £38.99
The Laboratory Hamster and Gerbil Catalog no. 2566, December 1998, 168 pp. Soft Cover, ISBN: 978-0-8493-2566-3, $59.95 / £38.99
The Laboratory Guinea Pig Catalog no. 2564, November 1997, 192 pp. Soft Cover, ISBN: 978-0-8493-2564-9, $57.95 / £36.99
The Laboratory Xenopus sp.
The Laboratory Cat
The Laboratory Canine
The Laboratory Rabbit
Catalog no. 2567, November 1997, 160 pp. Catalog no. 91093, December 2009, 180 pp. Soft Cover, ISBN: 978-1-4200-9109-0, $59.95 / £38.99 Soft Cover, ISBN: 978-0-8493-2567-0, $59.95 / £38.99 Catalog no. 2561, February 1997, 160 pp. Catalog no. 2893, October 2006, 184 pp. Soft Cover, ISBN: 978-0-8493-2893-0, $59.95 / £38.99 Soft Cover, ISBN: 978-0-8493-2561-8, $55.95 / £35.99
For more information and complete contents, visit www.crcpress.com
27
Lab Animal Science On DVD with Full-Color Companion Manuals
Laboratory Mouse and Laboratory Rat Procedural Techniques Manuals and DVDs John J. Bogdanske, Scott Hubbard-Van Stelle, Margaret Rankin Riley, and Beth M. Schiffman Research Animal Resources Center (RARC), University of Wisconsin, Madison, USA
“Currently, there is a paucity of training material for experimental techniques in laboratory rodents, particularly audiovisual material. The manuals and accompanying DVDs will be of great interest to students, technicians, veterinarians, and investigators. Importantly, the straightforward approach taken in both the printed manual and DVD will be seen as an excellent tool for non-English speaking personnel.” —Mark A. Suckow, DVM, Dipl. ACLAM, Director, Freimann Life Science Center, University of Notre Dame, & Past President of AALAS
“Students of animal technology can watch these videos to 'get the picture' and then practice with an experienced individual. It is a good refinement step of the 3Rs … . I will be very excited to have these manuals to use as training items with my students and as reference resources in our animal facility.” —Bruce W. Kennedy, Compliance Associate, Research & Graduate Studies, California State Polytechnic University, Pomona, & Past President of AALAS
Buy the set and save! Two Manuals and Two DVDs Catalog no. K12298, November 2010 192 pp., Soft Cover, ISBN: 978-1-4398-5050-3 $108.00 / £68.99
This combination of manuals and DVDs provides much-needed training on the proper handling of mice and rats used in biomedical research. The DVDs include narrated video clips that demonstrate and describe each procedural technique. The manuals contain handouts with color illustrations and descriptive text for each technique, including the purpose and application of the procedure, recommended skills, and necessary supplies. The pair can be used as a training resource and refresher for lab animal veterinarians, veterinary technicians, animal care staff, trainers, and research investigators and staff who work with mice and rats.
Each DVD provides: • Narrated video clips that demonstrate and describe each procedural technique • Easy navigation to desired techniques, including handling/transfer, oral gavage, blood draw, restraint, injection, and ear notching and tagging
Each manual includes: • Full text narratives and procedural handouts with color illustrations of each technique included on the DVD, including purpose and application of the procedure, recommended skills, and necessary supplies • Supplementary chapters that provide normative data for the laboratory rat and mouse
Also available individually
Laboratory Mouse Procedural Laboratory Rat Procedural Techniques Techniques Manual and DVD
Manual and DVD
Catalog no. K12294, November 2010, 100 pp. Soft Cover, ISBN: 978-1-4398-5042-8 $59.95 / £38.99
Catalog no. K12295, November 2010, 92 pp. Soft Cover, ISBN: 978-1-4398-5044-2 $59.95 / £38.99
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Lab Animal Science Atlas of the Neonatal Rat Brain
The Minipig in Biomedical Research Edited by
Renuka Ramachandra and Thyagarajan Subramanian
Peter A. McAnulty
The Pennsylvania State University Hershey Medical Center, USA
Anthony D. Dayan
Changes in the rat brain are rapid in the first two weeks after birth. Atlas of the Neonatal Rat Brain provides researchers in neurology, pharmacology, biology, and veterinary science with detailed color images of the normal developing rat brain. It presents photographic, histological illustrations of the anatomical features of the neonatal rat brain at postnatal (P) days P-1, P-7, and P-14.
Ellegaard Gottingen Minipigs A/S, Dalmose, Denmark
Each plate is a photomicrograph composite that shows the entire brain in sagittal and coronal sections at each stage. The P-1 section contains 30 coronal plates and 14 sagittal plates and the P-7 section includes 27 coronal plates and 24 sagittal plates. The final P-14 section shows 41 coronal plates and 21 sagittal plates. Each set consists of contiguous sections from individual animals, and selections were based on the structural variability represented. The sections are Nissl stained with Cresyl violet creating photomicrographs with high resolution and clarity. The structures are directly labeled on the images, making it easier to correlate data. Additional images are available as electronic resources for individuals who seek images not represented in this volume, and the electronic version allows labels to be removed so the atlas can be used as a teaching tool.
Non-Clinical Consultant, Roskilde, Denmark London, UK
Niels-Christian Ganderup Kenneth L. Hastings Sanofi-aventis, Bethesda, Maryland, USA
The first comprehensive single-source reference on the minipig, this accessible manual discusses its potential and use as a model. Written by acknowledged experts in the field, the book describes best practices in husbandry, transport, and experimentation. It explains and illustrates clinical, practical, and experimental techniques and procedures. It provides many examples of successful use of the minipig in basic and regulatory toxicity studies of drugs and devices. It also discusses clinical and physiological findings and laboratory values in health and disease. A 48-page color insert is included.
Catalog no. K10559, December 2011, 662 pp. ISBN: 978-1-4398-1118-4, $189.95 / £121.00 Also available as an eBook
Contents:
Biodefense Research Methodology and Animal Models
Preface
Second Edition
Acknowledgements
Edited by
Introduction
James R. Swearengen
Nomenclature Histology Imaging Atlas Plates: PI Rat Brain, P7 Rat Brain, PI4 Rat Brain Index
Catalog no. K11857, January 2011, 188 pp. ISBN: 978-1-4398-4012-2, $159.95 / £108.00 Also available as an eBook
National Biodefense Analysis and Countermeasures Center, Frederick, Maryland, USA
Since the publication of the first edition of this volume, significant advances have been made in animal model development for biological research, and the ramifications of the FDA’s Animal Efficacy Rule have become better understood in the scientific community. With each chapter completely updated, this volume spans the spectrum of coverage from basic research to advanced development of medical countermeasures. Topics discussed include a history of biological agents as weapons, concepts and strategies involved in biowarfare and bioterrorism, animal models in biodefense research, and infectious disease aerobiology. The book also presents studies involving a range of specific diseases and toxins.
Catalog no. K11643, February 2012, 415 pp. ISBN: 978-1-4398-3632-3, $129.95 / £82.00 Also available as an eBook
For more information and complete contents, visit www.crcpress.com
29
Lab Animal Science Stereotaxic and Chemoarchitectural Atlas of the Brain of the Common Marmoset (Callithrix jacchus) Craig D. Hardman and Ken W. S. Ashwell University of New South Wales, Sydney, Australia
Written for international neuroscientists engaged in research of neurological disorders such as Parkinson’s disease, Multiple Sclerosis, and Alzheimer’s disease, as well as professionals working in laboratories conducting pharmacokinetic studies, this book is the first comprehensive stereotaxic atlas of all parts of the marmoset brain, including up-to-date data on cortical areas. The book provides precise stereotaxic co-ordinates, functionally important chemoarchitectural information, and estimates for the numbers of neurons within important brain regions and nuclei. It also provides information for assessing the efficacy of treatments in marmoset models.
Catalog no. K11718, January 2012, 515 pp. ISBN: 978-1-4398-3778-8, $179.95 / £114.00 Also available as an eBook
The COST Manual of Laboratory Animal Care and Use Refinement, Reduction, and Research Edited by
Bryan Howard Former Director of Animal Welfare, University of Sheffield, UK
Timo Nevalainen University of Eastern Finland, Kuopio
Gemma Perretta Italian National Research Council, Santa Maria di Galeria, Italy
COST (European Cooperation in the field of Scientific and Technical Research) is an intergovernmental initiative in science and research intended to promote the coordination of nationally funded research in Europe. In this volume, four working groups discuss the housing of animals, their environmental needs, refinement of procedures, genetically modified animals, and cost-benefit analysis. Based on the activities of these working groups, the book provides the European best practices for individuals and institutions working with laboratory animals. The text also discusses the ethical evaluation of experiments and procedures involving animals.
Catalog no. K11184, October 2010, 439 pp. ISBN: 978-1-4398-2492-4, $89.95 / £57.99
Bestseller!
The IACUC Handbook
Current Research in Animal Physiology
Second Edition Edited by
Jerald Silverman University of Massachusetts Medical School, Worcester, USA
Edited by
Victor S. Lamoureux Broome Community College, Binghamton, New York, USA
Animal physiology is the scientific study of how the bodies of animals function. How does an animal breathe, develop, eat and digest, reproduce, control its activities? The field encompasses the molecular, cellular, tissue, and organ systems of animals. This book looks at an eclectic selection of studies in animal physiology, including how animals adapt to their physical environments, how human interaction can affect animal functioning, and much more. Animals covered include cows, mice, eels, pigs, rabbits, cats, and dogs, as well as various insects.
Catalog no. N10605, December 2011, 318 pp. ISBN: 978-1-926692-79-1, $129.95 / £82.00 Also available as an eBook
Mark A. Suckow University of Notre Dame, Indiana, USA
Sreekant Murthy Drexel University, Philadelphia, Pennsylvania, USA
Since its establishment by USDA regulation in the 1980s, the Institutional Animal Care and Use Committee has evolved as the premiere US instrument for animal welfare supervision. This volume provides a foundation for those attempting to understand and implement the various responsibilities of this committee. This edition features comprehensive updates for all pertinent federal laws, regulations, and policies, incorporating revised suggestions on bestpractice compliance from experienced professionals. With concise, easy-to-find information, it remains the reference of choice for researchers and professionals.
Catalog no. 4010, October 2006, 680 pp. ISBN: 978-0-8493-4010-9, $89.95 / £57.99
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