Co-authored by former presidents of the Zebrafish Husbandry Association
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Claudia Harper Amgen Inc., Cambridge, MA, USA
Christian Lawrence Children’s Hospital Boston, MA, USA Series: Laboratory Animal Pocket Reference Series editor: Mark A. Suckow
From Zebrafish Anatomy: Danio rerio poster. Copyright 2007, AALAS.
Photo courtesy of Christian Mossiman.
The first of its kind – an all inclusive scientific treatment of the biology, care, and management of this important animal model Second only to the mouse and rat, the zebrafish is the most popular animal model in biomedical research. Rapid embryonic development and transparent organogenesis give zebrafish unique advantages in the study of biological pathways, vertebrate development, carcinogenicity, drug development, genomics, gene function, mutagenesis screening, and toxicology.
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In the relatively brief span of only a few decades, the zebrafish has gone from being a hobby fish to a mainstream model animal employed by scientists to study everything from stem cells to the basis of behavioral changes induced by drug addiction. This rapid advance has been fueled largely by numerous and impressive advances in technology, along with detailed characterization of the animal on a genetic and molecular level.
Photo courtesy of Dr. Trace Peterson, Oregon State University.
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However, there are few accepted and established standards for husbandry, management, and care for the fish in laboratory settings and even fewer comprehensive and constantly reliable resources. This handbook provides managers, veterinarians, investigators, technicians, and regulatory personnel with a concise yet thorough reference on zebrafish biology, care, husbandry, and management. It arms those fish workers with scientifically grounded principles and fundamental information that can be used to design sound fish care programs.
Photo courtesy of Aquatic Habitats, Inc.
Like other books in the Laboratory Animal Pocket Reference Series, this guide covers all aspects pertaining to the use of these organisms, including their basic biology, humane care and management, husbandry, life support systems, regulatory compliance, technical procedures, veterinary care, and water quality management.
Catalog no. K10378, December 2010, 274 pp., Softcover ISBN: 978-1-4398-0743-9, $59.95 / £38.99 *Your discounted price: $47.96 / £31.20 Use code 057LC when ordering online to save 20%. Hu, N. et al. 2001. The Anatomical Record, 264, 1–12. Reprinted with permission of John Wiley & Sons, Inc.
About The Authors
Features: • Provides a quick reference source for technicians, investigators, veterinarians, managers, and regulatory personnel • Presents basic information and common procedures in detail • Covers a broad range of topics including husbandry, regulatory compliance, technical procedures, veterinary care, and water quality management • Discusses the use of zebrafish to study biological pathways, vertebrate development, carcinogenicity, drug development, genomics, gene function, mutagenesis screening, and toxicology
This handbook is organized into seven chapters: • Biology • Husbandry • Life Support Systems • Management • Veterinary Care • Experimental Methodology • Resources The final chapter, Resources, provides the zebrafish user with lists of sources of additional information on the zebrafish model, as well as key references, professional organizations, and suppliers of equipment and supplies used in zebrafish husbandry and care.
Dr. Harper’s clinical experience in aquatic animal health includes working with biomedical research models and aquaculture species. She was the fish health columnist for Aquaculture Magazine from 2002 until 2007 and is the co-founder and a past president of the Zebrafish Husbandry Association (ZHA). Christian Lawrence, M.S. manages the Aquatic Resources Program at Children’s Hospital Boston, which is home to one of the largest and most active zebrafish research programs in the world. He earned his master of science in biology from the University of Massachusetts–Boston in 2006, where his graduate research focused on the environmental and genetic controls of sexual differentiation in the zebrafish. He also has a bachelor of science in wildlife conservation biology from Arizona State University and a bachelor of arts in communications from Seton Hall University.
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Claudia Harper, DVM, Dipl. ACLAM is currently a director at Amgen. Dr. Harper was previously a senior clinical veterinarian at Massachusetts General Hospital Center for Comparative Medicine, and a senior scientist at PharmaMar USA. She completed her veterinary degree at Tufts University and was a post-doctoral fellow in the Division of Comparative Medicine at the Massachusetts Institute of Technology. Her experience includes research and clinical and diagnostic work with aquatic biomedical research models in academia and the pharmaceutical industry. She played a key role at MIT in identifying, naming, and describing the aquatic Helicobacter cetorum. She has presented original research and given lectures nationally and internationally, and has authored and co-authored numerous scientific articles.
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Mr. Lawrence has worked with and managed zebrafish for nearly 10 years, spending time at Harvard University, the Marine Biological Laboratory, and Brigham and Women’s Hospital before moving on to Children’s Hospital Boston in 2008. He has authored a number of scientific papers on the biology, husbandry, and management of zebrafish. He is past president of the Zebrafish Husbandry Association (ZHA) and currently serves as the coordinator of the ZHA working groups program.
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