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Datasheet of AX20017 Description: AX20017 is a small-molecule protein kinase G (PknG) inhibitor with an IC50 of 0.39 μM. InVitro: The compound AX20017 inhibitor is bound deep within a narrow pocket formed by the inter lobe cleft of the PknG domain. The main chain Glu233:O and Val235:NH of PknG form hydrogen bonds with AX20017.AX20017 results in mycobacterial transfer to lysosomes and killing of the mycobacteria. AX20017 does not affect the human kinases, whereas the activity of PknG is effectively inhibited. AX20017 did not affect cellular morphology, membrane ruffling, or macropinocytosis.
Chemical Information Catalog
DC10412
Purity of current batch:
>98%
Molecular Weight (MW)
264.34
Molecular Formula
C13H16N2O2S
CAS No.
329221-38-7
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.