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Datasheet of TPX-0005
Description: TPX-0005, a novel ALK/ROS1/TRK inhibitor, effectively inhibited a broad spectrum of mutations including solvent front ALK G1202R, ROS1 G2032R and TRKA G595R mutants. TPX-0005 is a small molecule kinase inhibitor — for the treatment of non–small cell lung adenocarcinoma with an ALK, ROS1, or NTRK mutation.TPX-0005 demonstrates potent inhibitory effects against solvent mutations after multiple treatments, including ALK G1202R, ROS1 G2032R, TRKA G595R, and TRKC G623R.The FDA based its approval on the findings from the ongoing TRIDENT-1 trial (ClinicalTrial.gov Identifier: NCT03093116), a “phase 1/2, open-label, multi-center, first-in-human study of the safety, tolerability, pharmacokinetics, and anti-tumor activity of TPX-0005 in patients with advanced solid tumors harboring ALK, ROS1, or NTRK1-3 rearrangements.
Chemical Information Catalog
DC10463
Purity of current batch:
>98%
Molecular Weight (MW)
355.37
Molecular Formula
C18H18FN5O2
CAS No.
2058227-19-1
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.