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Datasheet of SB756050
Description: SB756050 is a selective TGR5 agonist currently in phase 1clinical trials for the treatment of type 2 diabetes.TGR5 is a bile acid receptor and a potential target for the treatment of type 2 diabetes (T2D). SB756050 is well‐tolerated; it is readily absorbed, exhibited nonlinear pharmacokinetics with a less than dose‐proportional increase in plasma exposure above 100 mg, and demonstrates no significant changes in exposure when co‐administered with sitagliptin. SB756050 demonstrates highly variable pharmacodynamic effects both within dose groups and between doses, with increases in glucose seen at the two lowest doses and no reduction in glucose seen at the two highest doses. The glucose effects of SB756050 þ sitagliptin are comparable to those of sitagliptin alone, even though gut hormone plasma profiles are different.
Chemical Information Catalog
DC10470
Purity of current batch:
>98%
Molecular Weight (MW)
500.59
Molecular Formula
C21H28N2O8S2
CAS No.
447410-57-3
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.