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Datasheet of Anavex 2-73
Description: Anavex 2-73 is a small molecule that activates the sigma-1 receptor, which is known to modulate cellular processes relevant to neurodegeneration. Specifically, Anavex 2-73 is thought to help restore cellular balance by targeting protein misfolding (when proteins fail to fold correctly, into a normal configuration, they do not work as intended), oxidative stress (which damages cells due oxygen molecules with free radicals, or unpaired electrons), mitochondrial dysfunction, inflammation, and cellular stress.The sigma-1 receptor is a small transmembrane protein, a stress reducing and survival protein, mainly located on the endoplasmic reticulum membrane of cells. This receptor is also present on the surface of some nerve cells and multiple other central nervous system cell types and tissues. As sigma-1 receptors are present in various sites, different physiological and pathological processes may be influenced by treatment with Anavex 2-73. The brain of a person with Alzheimer’s has fewer sigma-1 receptors than healthy people of the same age. Therefore the induction or activation of these receptors could improve the clinical symptoms of AD and protect against neurologic changes. Researchers believe that this activation may be achieved by the regulation of calcium and the reduction of oxidative stress.
Chemical Information Catalog
DC10612
Purity of current batch:
>98%
Molecular Weight (MW)
317.85
Molecular Formula
C19H23NO.HCl
CAS No.
195615-84-0
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.