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Datasheet of Targocil
Description: Targocil, a novel antibiotic against MRSA. The effects of Targocil has been shown that in murine model of endophthalmitis, and also tested the efficacies of Targocil for a panel of MSSA and MRSA isolates from cases of bacterial keratitis. It was found that Targocil is more effective than vancomycin in blocking intracellular S. aureus growth. Moreover, resistant mutants that arise upon selection with these compounds are highly attenuated and show reduced epithelial cell binding and invasion. Targocil is an inhibitor of TarG, the transmembrane component of the two component ABC transporter that exports WTAs from the cytoplasm to the external surface of the bacterial membrane where they are attached to peptidoglycan. Targocil has minimally inhibitory concentration (MIC) of 0.3 uM. Targocil shows inhibitory activities against both methicillin-sensitive and methicillin-resistant S. aureus strains. The acute toxicity of Targocil has been tested: doses of 75 mg/kg administered via tail vein injection caused no adverse effects in mice after 24 h.
Chemical Information Catalog
DC10624
Purity of current batch:
>98%
Molecular Weight (MW)
475.95
Molecular Formula
C21H22ClN5O4S
CAS No.
1200443-21-5
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.