Website:www.dcchemicals.com Email: info@dcchemicals.com Phone:+86-21-58447131 Marketing Center: Room 610,Building 15, Jinxiang Rd 201, Shanghai, China
Datasheet of Alovudine
Description: Alovudine is a dideoxynucleoside thymidine analogue, which when phosphorylated shows POLG inhibitory activity. Investigators from Medivir and their collaborators aimed to study the effects of alovudine in acute myeloid leukemia (AML) cells both in vitro and in vivo. The results showed that when OCI-AML2 cells were separately treated with alovudine and AraC, there was a reduction in the biogenesis of mtDNA and oxidative phosphorylation was impaired, as were cell growth and viability in alovudine-treated cells compared to AraC-treated cells. When alovudine was administered to AML mice (n = 10) (dosed at 50 mg/kg b.i.d. p.o.) for 11 days, it was shown that tumor volume was reduced in these mice compared to control mice (n = 10), as was tumor weight, showing a clear antileukemic activity. These results confirm alovudine to be a potent POLG inhibitor that impairs oxidative phosphorylation in AML, decreasing its growth both in vitro an in vivo
Chemical Information Catalog
DC10735
Purity of current batch:
>98%
Molecular Weight (MW)
244.09
Molecular Formula
C10H13FN2O4
CAS No.
25526-93-6
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.