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Datasheet of AB423
Description: AB-423 is a potent, highly seletive inhibitor of HBV replication through a block of pgRNA encapsidation. AB-423 in combination with EVT has shown synergistic antiviral activity in vitro in primary human hepatocytes. Furthermore, AB-423 alone and in combination with entecavir has shown potent in vivo activity in a hydrodynamic injection (HDI) mouse model of HBV.The HBV capsid inhibitor AB-423 exhibits a dual mode of inhibition:inhibited encapsidation of pgRNA during ongoing infection; inhibited cccDNA synthesis presumably via inhibition of the capsid uncoating step.In vitro AB-423 showed: pan-genotypic activity; potent activity against HBV in combination with Nucs, IFN, and RNAi agents;no significant activity against unrelated viruses.
Chemical Information Catalog
DC10797
Purity of current batch:
>98%
Molecular Weight (MW)
386.09
Molecular Formula
C17H17F3N2O3S
CAS No.
1572510-80-5
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.