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Datasheet of EPZ031686
Description: EPZ031686 is a noncompetitive inhibitor for SMYD3 and MEKK2 with a Ki=1.2 and 1.1 nM respectively. In vitro: EPZ031686 have a cellular potency at a level sufficient to probe the in vitro biology of SMYD3 inhibition. The first SMYD3 inhibitor identify to show double-digit nanomolar cellular activity. EPZ031686 show < 30% inhibition against 16 histone methyltransferase targets at a 10 uM screening concentration. In vivo: EPZ031686 show good bioavailability following oral dosing in mice. The administration for mice is 1 mg/kg by i.v.
Chemical Information Catalog
DC10887
Purity of current batch:
>98%
Molecular Weight (MW)
591.09
Molecular Formula
C26H34ClF3N4O4S
CAS No.
1808011-22-4
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.