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Datasheet of mutant EGFR inhibitor B30
Description: mutant EGFR inhibitor B30 is a potent, selective, next-generation EGFR mutants inhibitor with IC50 of 1.1 and 7.2 nM for EGFRL858R and EGFRL858R/T790M/C797S, respectively; weakly inhibits WT EGFR and double mutant L858R/T790M with IC50 of 10.4 and 34.0 nM; inhibits HCC827 and H1975?cells growth with IC50 of 44 and 400 nM, respectively, suppresses EGFR phosphorylation in a dose-dependent manner in HCC827?cell line and significantly induce the apoptosis of HCC827 cells.
Chemical Information Catalog
DC10915
Purity of current batch:
>98%
Molecular Weight (MW)
571.71
Molecular Formula
C31H38FN9O
CAS No.
2225887-26-1
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.