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Datasheet of COX-1 Inhibitor IV（TFAP）
Description: TFAP is a cell-permeable pyridinyl-benzamide compound that acts as a Cox-1 (IC50 of 0.80 μM) selective inhibitor versus Cox-2 (IC50 of 210 μM) by targeting the enzyme's active site and displays analgesic properties in mice and rats in vivo (30 mg/kg, p.o.) without long-term cytotoxic effects (300 mg/kg in mice, daily, p.o. for 14 days). Unlike Cox-2-inhibiting analgesics such as aspirin, TFAP is shown not to cause gastric damage in rats in vivo (300 mg/kg, p.o.).
Chemical Information Catalog
DC11263
Purity of current batch:
>98%
Molecular Weight (MW)
281.23
Molecular Formula
C13H10F3N3O
CAS No.
1011244-68-0
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.