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Datasheet of Dasatinib monohydrate
Description: Description of Dasatinib: Dasatinib is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity For the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic Forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) For the detailed information about the solubility of Dasatinib monohydrate in water, the solubility of Dasatinib monohydrate in DMSO, the solubility of Dasatinib monohydrate in PBS buffer, the animal experiment（test） of Dasatinib monohydrate,the in vivo,in vitro and clinical trial test of Dasatinib monohydrate,the cell experiment（test） of Dasatinib monohydrate,the IC50, EC50 and Affinity of Dasatinib monohydrate, please contact DC Chemicals..
Chemical Information Catalog
DC3140
Purity of current batch:
>98%
Molecular Weight (MW)
506.02
Molecular Formula
C22H28ClN7O3S
CAS No.
863127-77-9
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.