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Datasheet of PP1
Description: PP1(AGL 1872) is a potent and selective Src inhibitor for Lck/Fyn with IC50 of 5 nM/ 6 nM. IC50 Value: 0.2 uM (recombinant p60c-src); 0.1 uM (PDGF b-receptor in Swiss 3T3 cell) in vitro: PP1/AGL1872 inhibits p60c-src in vitro with an IC50 of 0.2 mmol/L; ie, we found an IC50 '50 times higher than that reported for inhibition of p56Lck in vitro.27 PP2/AGL1879 had a somewhat lower activity in this assay with an IC50 of 0.3 mmol/L [1]. PP1/AGL1872 potently inhibit PDGF b-receptor autokinase activity in Swiss 3T3 cell membranes (IC50 0.1 mmol/L), in preparations of partially purified human PDGF b-receptor (IC50 0.1 mmol/L) and in intact Swiss 3T3 cells (IC50 0.5 mmol/L). PP1/AGL1872 differentially affects cell proliferation driven by different growth factors [1]. Sphingosine and PP1/AGL1872 inhibit the transcription of ks1, an early regeneration gene, at 24 and 48 h of treatment. Sphingosine 2 microM arrested the cells on the G1 phase of the cell cycle, but 1 microM of PP1/AGL1872 did not . Clinical trial: Study of Milnacipran Added to Pregabalin for Treatment of Fibromyalgia. Phase 3
Chemical Information Catalog
DC5007
Purity of current batch:
>98%
Molecular Weight (MW)
281.36
Molecular Formula
C16H19N5
CAS No.
172889-26-8
Solubility (25째C)
DMSO
Storage
Store at -20째C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20째C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.