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Datasheet of EX-527
Description: EX-527 S-enantiomer is a potent and selective SIRT1 inhibitor with IC50 of 123 nM; no inhibition on SIRT3 and SIRT3. EX-527 S-enantiomer is the S-enantiomer of EX-527, EX-527 racemic has an IC50 of 98 nM for SIRT1, in the reference paper, Compound 35S has good potency than 35R, so we speculate that EX-527 S enantiomer is the active form vs R enantiomer. Just for reference!
Chemical Information Catalog
DC7127
Purity of current batch:
>98%
Molecular Weight (MW)
248.71
Molecular Formula
C13H13ClN2O
CAS No.
848193-68-0
Solubility (25째C)
DMSO
Storage
Store at -20째C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20째C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.