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Datasheet of NMS-873
Description: NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with IC50 value of 20 nM (Wild Type, 1 mM ATP). in vitro: In standard assay conditions, NMS-873 had an IC50 of 30 nM, which was unchanged at saturating ATP concentration. NMS-862, which has micromolar biochemical potency, did not have measurable antiproliferative activity (IC50 >10 μM), whereas the nanomolar activity of NMS-873 translated into a submicromolar antiproliferative IC50 in HCT116 (0.4 μM) and HeLa (0.7 μM) cells. We measured IC50 values in the range of 0.08 μM to 2 μM for NMS-873 in a panel of tumor cell lines that suggested potent but somehow selective inhibitor activity in different tumor cell lines...
Chemical Information Catalog
DC7212
Purity of current batch:
>98%
Molecular Weight (MW)
520.67
Molecular Formula
C27H28N4O3S2
CAS No.
1418013-75-8
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.