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Datasheet of Zolpidem
Description:. Zolpidem(SL 800750) is an inhibitory neurotransmitter, by binding to GABAA receptors at the same location as benzodiazepines. in vitro: All granule cell GABAR currents were uniformly sensitive to Zn2+ (IC50 = 29 microM), diazepam (EC50 = 158 nM), zolpidem (EC50 = 75 nM), and dimethoxyl-4-ethyl-beta-carboline-3-carboxylate (IC50 = 60 nM). The kinetic profile for zolpidem metabolite formation by each individual cytochrome was combined with estimated relative abundances based on immunological quantification, yielding projected contributions to net intrinsic clearance of: 61% for 3 A4, 22% for 2C9, 14% for 1A2, and less than 3% for 2D6 and 2C19. in vivo: Studying alpha1(H101R) mice, which possess zolpidem-insensitive alpha(1)-GABA(A) receptors, we show that the sedative action of zolpidem is exclusively mediated by alpha(1)-GABA(A) receptors. In wild type mice, zolpidem depressed motor activity in a dose-dependent manner (P50.01 versus vehicle) similar to diazepam. However, in a1(H101R) mice zolpidem up to 60 mg kg71 did not decrease motor activity.
Chemical Information Catalog
DC7345
Purity of current batch:
>98%
Molecular Weight (MW)
307.38954
Molecular Formula
C19H21N3O
CAS No.
82626-48-0
Solubility (25째C)
DMSO
Storage
Store at -20째C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20째C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.