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Datasheet of Bromosporine
Description:. Bromosporine is a broad spectrum inhibitor for bromodomains with IC50 of 0.41 μM, 0.29 μM, 0.122 μM and 0.017 μM for BRD2, BRD4, BRD9 and CECR2, respectively. In cell-based assays, Bromosporine (1 μM) accelerates FRAP recovery of BRD4 and CREBBP, while shows no activities against TIF1α, BAZ2A, and SMARCA2 even at 10 μM. Bromosporine shows moderate cytotoxicity in HeLa cells at 18 μM. Bromosporine, as a chemical probe for bromodomain functional assays, will be very useful in elucidating further biological roles of reader domains. .Accelerates FRAP recovery of BRD4 and CREBBP in cells at a concentration of 1 μM.For the detailed information of Bromosporine, the solubility of Bromosporine in water, the solubility of Bromosporine in DMSO, the solubility of Bromosporine in PBS buffer, the animal experiment (test) of Bromosporine, the cell expriment (test) of Bromosporine, the in vivo, in vitro and clinical trial test of Bromosporine, the EC50, IC50,and Affinity of Bromosporine, Please contact DC Chemicals.
Chemical Information Catalog
DC7543
Purity of current batch:
>98%
Molecular Weight (MW)
404.44
Molecular Formula
C17H20N6O4S
CAS No.
1619994-69-2
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.