CA-074-Me|inhibitor of cathepsin B

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Datasheet of CA-074-Me

Description:. CA-074 Me is a membrane-permeable and selective inhibitor of cathepsin B with IC50 value of 36.3 nM [1, 2]. CA-074 Me is a methyl ester derivative of CA-074. In cultured human gingival fibroblasts, CA-074 Me exerted a 95% inhibition of cathepsin B and partial inhibition (54%) of the combined activities of cathepsins B and L. CA-074 Me was also found to inhibit cathespin L under reducing conditions. It inhibited the activity of purified human cathepsin L by more than 90% when the enzyme had been pre-incubated with 1.4 mM DTT or 4.2 mM GSH for 2 hours. Besides that, CA-074 Me completely inhibited cathepsin B in the presence of 1.4 mM DTT [2, 3].For the detailed information about the solubility of CA-074 Me in water, the solubility of CA-074 Me in DMSO, the solubility of CA-074 Me in PBS buffer, the animal experiment of CA-074 Me ,the in vivo and in vitro test of CA-074 Me ,the cell experiment of CA-074 Me ,the IC50 and EC50 of CA-074 Me please contact DC Chemicals.

Chemical Information Catalog

DC7697

Purity of current batch:

>98%

Molecular Weight (MW)

397.5

Molecular Formula

C19H31N3O6

CAS No.

147859-80-1

Solubility (25°C)

DMSO

Storage

Store at -20°C (desiccating conditions).

Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.


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